-- dump date 20140619_121511 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272620000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 272620000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 272620000003 putative catalytic residues [active] 272620000004 putative nucleotide binding site [chemical binding]; other site 272620000005 putative aspartate binding site [chemical binding]; other site 272620000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 272620000007 dimer interface [polypeptide binding]; other site 272620000008 putative threonine allosteric regulatory site; other site 272620000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 272620000010 putative threonine allosteric regulatory site; other site 272620000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272620000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272620000013 homoserine kinase; Provisional; Region: PRK01212 272620000014 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272620000015 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272620000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 272620000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 272620000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620000019 catalytic residue [active] 272620000020 hypothetical protein; Validated; Region: PRK02101 272620000021 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 272620000022 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 272620000023 transaldolase-like protein; Provisional; Region: PTZ00411 272620000024 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 272620000025 active site 272620000026 dimer interface [polypeptide binding]; other site 272620000027 catalytic residue [active] 272620000028 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272620000029 MPT binding site; other site 272620000030 trimer interface [polypeptide binding]; other site 272620000031 metabolite-proton symporter; Region: 2A0106; TIGR00883 272620000032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620000033 putative substrate translocation pore; other site 272620000034 hypothetical protein; Provisional; Region: PRK10659 272620000035 hypothetical protein; Provisional; Region: PRK10236 272620000036 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 272620000037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 272620000038 hypothetical protein; Provisional; Region: PRK10154 272620000039 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272620000040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272620000041 nucleotide binding site [chemical binding]; other site 272620000042 chaperone protein DnaJ; Provisional; Region: PRK10767 272620000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272620000044 HSP70 interaction site [polypeptide binding]; other site 272620000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 272620000046 substrate binding site [polypeptide binding]; other site 272620000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272620000048 Zn binding sites [ion binding]; other site 272620000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272620000050 dimer interface [polypeptide binding]; other site 272620000051 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 272620000052 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 272620000053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620000054 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 272620000055 putative dimerization interface [polypeptide binding]; other site 272620000056 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272620000057 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272620000058 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272620000059 active site 272620000060 Riboflavin kinase; Region: Flavokinase; smart00904 272620000061 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272620000062 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272620000063 HIGH motif; other site 272620000064 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272620000065 active site 272620000066 KMSKS motif; other site 272620000067 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272620000068 tRNA binding surface [nucleotide binding]; other site 272620000069 anticodon binding site; other site 272620000070 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272620000071 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 272620000072 lipoprotein signal peptidase; Provisional; Region: PRK14787 272620000073 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 272620000074 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272620000075 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 272620000076 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 272620000077 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 272620000078 active site 272620000079 tetramer interface [polypeptide binding]; other site 272620000080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620000081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620000082 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620000083 putative effector binding pocket; other site 272620000084 dimerization interface [polypeptide binding]; other site 272620000085 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 272620000086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620000087 active site 272620000088 phosphorylation site [posttranslational modification] 272620000089 intermolecular recognition site; other site 272620000090 dimerization interface [polypeptide binding]; other site 272620000091 Transcriptional regulator; Region: CitT; pfam12431 272620000092 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 272620000093 PAS domain; Region: PAS; smart00091 272620000094 putative active site [active] 272620000095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620000096 ATP binding site [chemical binding]; other site 272620000097 Mg2+ binding site [ion binding]; other site 272620000098 G-X-G motif; other site 272620000099 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 272620000100 oxaloacetate decarboxylase; Provisional; Region: PRK14040 272620000101 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272620000102 active site 272620000103 catalytic residues [active] 272620000104 metal binding site [ion binding]; metal-binding site 272620000105 homodimer binding site [polypeptide binding]; other site 272620000106 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272620000107 carboxyltransferase (CT) interaction site; other site 272620000108 biotinylation site [posttranslational modification]; other site 272620000109 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 272620000110 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 272620000111 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 272620000112 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 272620000113 putative active site [active] 272620000114 (T/H)XGH motif; other site 272620000115 citrate lyase acyl carrier protein; Region: citD; TIGR01608 272620000116 citrate lyase, beta subunit; Region: citE; TIGR01588 272620000117 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 272620000118 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 272620000119 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 272620000120 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 272620000121 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 272620000122 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 272620000123 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 272620000124 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 272620000125 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 272620000126 catalytic site [active] 272620000127 subunit interface [polypeptide binding]; other site 272620000128 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 272620000129 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272620000130 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272620000131 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 272620000132 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272620000133 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272620000134 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 272620000135 IMP binding site; other site 272620000136 dimer interface [polypeptide binding]; other site 272620000137 interdomain contacts; other site 272620000138 partial ornithine binding site; other site 272620000139 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 272620000140 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 272620000141 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 272620000142 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 272620000143 TrkA-N domain; Region: TrkA_N; pfam02254 272620000144 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272620000145 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272620000146 folate binding site [chemical binding]; other site 272620000147 NADP+ binding site [chemical binding]; other site 272620000148 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 272620000149 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 272620000150 active site 272620000151 metal binding site [ion binding]; metal-binding site 272620000152 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 272620000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272620000154 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 272620000155 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 272620000156 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272620000157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 272620000158 SurA N-terminal domain; Region: SurA_N; pfam09312 272620000159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272620000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 272620000161 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 272620000162 OstA-like protein; Region: OstA; pfam03968 272620000163 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272620000164 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 272620000165 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 272620000166 putative metal binding site [ion binding]; other site 272620000167 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272620000168 HSP70 interaction site [polypeptide binding]; other site 272620000169 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 272620000170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620000171 active site 272620000172 phosphorylation site [posttranslational modification] 272620000173 intermolecular recognition site; other site 272620000174 dimerization interface [polypeptide binding]; other site 272620000175 Transcriptional regulator; Region: CitT; pfam12431 272620000176 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 272620000177 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 272620000178 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272620000179 putative active site [active] 272620000180 heme pocket [chemical binding]; other site 272620000181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620000182 ATP binding site [chemical binding]; other site 272620000183 Mg2+ binding site [ion binding]; other site 272620000184 G-X-G motif; other site 272620000185 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 272620000186 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 272620000187 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272620000188 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272620000189 active site 272620000190 ATP-dependent helicase HepA; Validated; Region: PRK04914 272620000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620000192 ATP binding site [chemical binding]; other site 272620000193 putative Mg++ binding site [ion binding]; other site 272620000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620000195 nucleotide binding region [chemical binding]; other site 272620000196 ATP-binding site [chemical binding]; other site 272620000197 DNA polymerase II; Reviewed; Region: PRK05762 272620000198 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 272620000199 active site 272620000200 catalytic site [active] 272620000201 substrate binding site [chemical binding]; other site 272620000202 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 272620000203 active site 272620000204 metal-binding site 272620000205 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 272620000206 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 272620000207 intersubunit interface [polypeptide binding]; other site 272620000208 active site 272620000209 Zn2+ binding site [ion binding]; other site 272620000210 L-arabinose isomerase; Provisional; Region: PRK02929 272620000211 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 272620000212 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 272620000213 trimer interface [polypeptide binding]; other site 272620000214 putative substrate binding site [chemical binding]; other site 272620000215 putative metal binding site [ion binding]; other site 272620000216 ribulokinase; Provisional; Region: PRK04123 272620000217 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 272620000218 N- and C-terminal domain interface [polypeptide binding]; other site 272620000219 active site 272620000220 MgATP binding site [chemical binding]; other site 272620000221 catalytic site [active] 272620000222 metal binding site [ion binding]; metal-binding site 272620000223 carbohydrate binding site [chemical binding]; other site 272620000224 homodimer interface [polypeptide binding]; other site 272620000225 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 272620000226 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620000227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620000228 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620000229 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272620000230 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272620000231 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 272620000232 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 272620000233 Walker A/P-loop; other site 272620000234 ATP binding site [chemical binding]; other site 272620000235 Q-loop/lid; other site 272620000236 ABC transporter signature motif; other site 272620000237 Walker B; other site 272620000238 D-loop; other site 272620000239 H-loop/switch region; other site 272620000240 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 272620000241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620000242 dimer interface [polypeptide binding]; other site 272620000243 conserved gate region; other site 272620000244 putative PBP binding loops; other site 272620000245 ABC-ATPase subunit interface; other site 272620000246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620000247 dimer interface [polypeptide binding]; other site 272620000248 conserved gate region; other site 272620000249 putative PBP binding loops; other site 272620000250 ABC-ATPase subunit interface; other site 272620000251 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 272620000252 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 272620000253 transcriptional regulator SgrR; Provisional; Region: PRK13626 272620000254 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 272620000255 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 272620000256 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620000257 sugar efflux transporter; Region: 2A0120; TIGR00899 272620000258 putative substrate translocation pore; other site 272620000259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620000260 D-galactonate transporter; Region: 2A0114; TIGR00893 272620000261 putative substrate translocation pore; other site 272620000262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620000263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620000264 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 272620000265 putative dimerization interface [polypeptide binding]; other site 272620000266 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 272620000267 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 272620000268 active site 272620000269 catalytic residue [active] 272620000270 dimer interface [polypeptide binding]; other site 272620000271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620000272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620000273 putative substrate translocation pore; other site 272620000274 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 272620000275 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272620000276 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272620000277 shikimate binding site; other site 272620000278 NAD(P) binding site [chemical binding]; other site 272620000279 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272620000280 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 272620000281 active site 272620000282 FMN binding site [chemical binding]; other site 272620000283 substrate binding site [chemical binding]; other site 272620000284 putative catalytic residue [active] 272620000285 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272620000286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620000287 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 272620000288 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 272620000289 substrate binding site [chemical binding]; other site 272620000290 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 272620000291 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 272620000292 substrate binding site [chemical binding]; other site 272620000293 ligand binding site [chemical binding]; other site 272620000294 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 272620000295 tartrate dehydrogenase; Region: TTC; TIGR02089 272620000296 2-isopropylmalate synthase; Validated; Region: PRK00915 272620000297 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 272620000298 active site 272620000299 catalytic residues [active] 272620000300 metal binding site [ion binding]; metal-binding site 272620000301 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 272620000302 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 272620000303 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620000304 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 272620000305 putative substrate binding pocket [chemical binding]; other site 272620000306 putative dimerization interface [polypeptide binding]; other site 272620000307 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 272620000308 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620000309 PYR/PP interface [polypeptide binding]; other site 272620000310 dimer interface [polypeptide binding]; other site 272620000311 TPP binding site [chemical binding]; other site 272620000312 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620000313 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272620000314 TPP-binding site [chemical binding]; other site 272620000315 dimer interface [polypeptide binding]; other site 272620000316 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 272620000317 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272620000318 putative valine binding site [chemical binding]; other site 272620000319 dimer interface [polypeptide binding]; other site 272620000320 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 272620000321 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 272620000322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620000323 DNA binding site [nucleotide binding] 272620000324 domain linker motif; other site 272620000325 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 272620000326 dimerization interface [polypeptide binding]; other site 272620000327 ligand binding site [chemical binding]; other site 272620000328 mraZ protein; Region: TIGR00242 272620000329 MraZ protein; Region: MraZ; pfam02381 272620000330 MraZ protein; Region: MraZ; pfam02381 272620000331 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 272620000332 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272620000333 cell division protein FtsL; Provisional; Region: PRK10772 272620000334 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 272620000335 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272620000336 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272620000337 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 272620000338 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272620000339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272620000340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272620000341 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 272620000342 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272620000343 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272620000344 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272620000345 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 272620000346 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 272620000347 Mg++ binding site [ion binding]; other site 272620000348 putative catalytic motif [active] 272620000349 putative substrate binding site [chemical binding]; other site 272620000350 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 272620000351 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272620000352 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272620000353 cell division protein FtsW; Provisional; Region: PRK10774 272620000354 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 272620000355 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 272620000356 active site 272620000357 homodimer interface [polypeptide binding]; other site 272620000358 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 272620000359 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272620000360 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272620000361 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272620000362 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 272620000363 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272620000364 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272620000365 cell division protein FtsQ; Provisional; Region: PRK10775 272620000366 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 272620000367 Cell division protein FtsQ; Region: FtsQ; pfam03799 272620000368 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 272620000369 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620000370 Cell division protein FtsA; Region: FtsA; pfam14450 272620000371 cell division protein FtsZ; Validated; Region: PRK09330 272620000372 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272620000373 nucleotide binding site [chemical binding]; other site 272620000374 SulA interaction site; other site 272620000375 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 272620000376 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 272620000377 SecA regulator SecM; Provisional; Region: PRK02943 272620000378 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272620000379 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 272620000380 SEC-C motif; Region: SEC-C; pfam02810 272620000381 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272620000382 active site 272620000383 8-oxo-dGMP binding site [chemical binding]; other site 272620000384 nudix motif; other site 272620000385 metal binding site [ion binding]; metal-binding site 272620000386 DNA gyrase inhibitor; Reviewed; Region: PRK00418 272620000387 hypothetical protein; Provisional; Region: PRK05287 272620000388 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272620000389 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272620000390 CoA-binding site [chemical binding]; other site 272620000391 ATP-binding [chemical binding]; other site 272620000392 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 272620000393 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272620000394 active site 272620000395 type IV pilin biogenesis protein; Provisional; Region: PRK10573 272620000396 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272620000397 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272620000398 hypothetical protein; Provisional; Region: PRK10436 272620000399 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272620000400 Walker A motif; other site 272620000401 ATP binding site [chemical binding]; other site 272620000402 Walker B motif; other site 272620000403 putative major pilin subunit; Provisional; Region: PRK10574 272620000404 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272620000405 Pilin (bacterial filament); Region: Pilin; pfam00114 272620000406 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 272620000407 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 272620000408 dimerization interface [polypeptide binding]; other site 272620000409 active site 272620000410 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 272620000411 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272620000412 amidase catalytic site [active] 272620000413 Zn binding residues [ion binding]; other site 272620000414 substrate binding site [chemical binding]; other site 272620000415 regulatory protein AmpE; Provisional; Region: PRK10987 272620000416 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 272620000417 active site 272620000418 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620000419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620000420 putative substrate translocation pore; other site 272620000421 aromatic amino acid transporter; Provisional; Region: PRK10238 272620000422 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 272620000423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620000424 DNA-binding site [nucleotide binding]; DNA binding site 272620000425 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272620000426 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 272620000427 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 272620000428 dimer interface [polypeptide binding]; other site 272620000429 TPP-binding site [chemical binding]; other site 272620000430 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 272620000431 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272620000432 E3 interaction surface; other site 272620000433 lipoyl attachment site [posttranslational modification]; other site 272620000434 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272620000435 E3 interaction surface; other site 272620000436 lipoyl attachment site [posttranslational modification]; other site 272620000437 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272620000438 E3 interaction surface; other site 272620000439 lipoyl attachment site [posttranslational modification]; other site 272620000440 e3 binding domain; Region: E3_binding; pfam02817 272620000441 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272620000442 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 272620000443 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620000444 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620000445 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272620000446 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 272620000447 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 272620000448 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 272620000449 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 272620000450 substrate binding site [chemical binding]; other site 272620000451 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 272620000452 substrate binding site [chemical binding]; other site 272620000453 ligand binding site [chemical binding]; other site 272620000454 hypothetical protein; Provisional; Region: PRK05248 272620000455 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 272620000456 spermidine synthase; Provisional; Region: PRK00811 272620000457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620000458 S-adenosylmethionine binding site [chemical binding]; other site 272620000459 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 272620000460 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 272620000461 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272620000462 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 272620000463 multicopper oxidase; Provisional; Region: PRK10965 272620000464 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272620000465 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272620000466 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272620000467 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 272620000468 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 272620000469 Trp docking motif [polypeptide binding]; other site 272620000470 putative active site [active] 272620000471 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620000472 active site 272620000473 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 272620000474 active site clefts [active] 272620000475 zinc binding site [ion binding]; other site 272620000476 dimer interface [polypeptide binding]; other site 272620000477 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272620000478 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272620000479 Walker A/P-loop; other site 272620000480 ATP binding site [chemical binding]; other site 272620000481 Q-loop/lid; other site 272620000482 ABC transporter signature motif; other site 272620000483 Walker B; other site 272620000484 D-loop; other site 272620000485 H-loop/switch region; other site 272620000486 inner membrane transport permease; Provisional; Region: PRK15066 272620000487 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272620000488 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620000489 active pocket/dimerization site; other site 272620000490 active site 272620000491 phosphorylation site [posttranslational modification] 272620000492 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 272620000493 putative active site [active] 272620000494 putative metal binding site [ion binding]; other site 272620000495 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 272620000496 tetramerization interface [polypeptide binding]; other site 272620000497 active site 272620000498 pantoate--beta-alanine ligase; Region: panC; TIGR00018 272620000499 Pantoate-beta-alanine ligase; Region: PanC; cd00560 272620000500 active site 272620000501 ATP-binding site [chemical binding]; other site 272620000502 pantoate-binding site; other site 272620000503 HXXH motif; other site 272620000504 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 272620000505 oligomerization interface [polypeptide binding]; other site 272620000506 active site 272620000507 metal binding site [ion binding]; metal-binding site 272620000508 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 272620000509 catalytic center binding site [active] 272620000510 ATP binding site [chemical binding]; other site 272620000511 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 272620000512 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272620000513 active site 272620000514 NTP binding site [chemical binding]; other site 272620000515 metal binding triad [ion binding]; metal-binding site 272620000516 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272620000517 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 272620000518 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 272620000519 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 272620000520 active site 272620000521 nucleotide binding site [chemical binding]; other site 272620000522 HIGH motif; other site 272620000523 KMSKS motif; other site 272620000524 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 272620000525 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 272620000526 2'-5' RNA ligase; Provisional; Region: PRK15124 272620000527 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272620000528 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 272620000529 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 272620000530 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620000531 ATP binding site [chemical binding]; other site 272620000532 putative Mg++ binding site [ion binding]; other site 272620000533 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620000534 nucleotide binding region [chemical binding]; other site 272620000535 ATP-binding site [chemical binding]; other site 272620000536 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 272620000537 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272620000538 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 272620000539 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272620000540 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 272620000541 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 272620000542 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 272620000543 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 272620000544 GspL periplasmic domain; Region: GspL_C; pfam12693 272620000545 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 272620000546 type II secretion system protein J; Region: gspJ; TIGR01711 272620000547 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 272620000548 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272620000549 type II secretion system protein I; Region: gspI; TIGR01707 272620000550 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 272620000551 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 272620000552 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 272620000553 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 272620000554 type II secretion system protein F; Region: GspF; TIGR02120 272620000555 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272620000556 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 272620000557 type II secretion system protein E; Region: type_II_gspE; TIGR02533 272620000558 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 272620000559 Walker A motif; other site 272620000560 ATP binding site [chemical binding]; other site 272620000561 Walker B motif; other site 272620000562 type II secretion system protein D; Region: type_II_gspD; TIGR02517 272620000563 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272620000564 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272620000565 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272620000566 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272620000567 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 272620000568 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 272620000569 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 272620000570 carbohydrate binding site [chemical binding]; other site 272620000571 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 272620000572 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 272620000573 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 272620000574 Ca binding site [ion binding]; other site 272620000575 active site 272620000576 catalytic site [active] 272620000577 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 272620000578 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 272620000579 Transglycosylase; Region: Transgly; pfam00912 272620000580 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272620000581 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 272620000582 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620000583 N-terminal plug; other site 272620000584 ligand-binding site [chemical binding]; other site 272620000585 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 272620000586 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620000587 Walker A/P-loop; other site 272620000588 ATP binding site [chemical binding]; other site 272620000589 Q-loop/lid; other site 272620000590 ABC transporter signature motif; other site 272620000591 Walker B; other site 272620000592 D-loop; other site 272620000593 H-loop/switch region; other site 272620000594 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272620000595 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272620000596 siderophore binding site; other site 272620000597 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620000598 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620000599 ABC-ATPase subunit interface; other site 272620000600 dimer interface [polypeptide binding]; other site 272620000601 putative PBP binding regions; other site 272620000602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620000603 ABC-ATPase subunit interface; other site 272620000604 dimer interface [polypeptide binding]; other site 272620000605 putative PBP binding regions; other site 272620000606 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 272620000607 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620000608 inhibitor-cofactor binding pocket; inhibition site 272620000609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620000610 catalytic residue [active] 272620000611 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272620000612 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 272620000613 Cl- selectivity filter; other site 272620000614 Cl- binding residues [ion binding]; other site 272620000615 pore gating glutamate residue; other site 272620000616 dimer interface [polypeptide binding]; other site 272620000617 H+/Cl- coupling transport residue; other site 272620000618 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 272620000619 hypothetical protein; Provisional; Region: PRK10578 272620000620 UPF0126 domain; Region: UPF0126; pfam03458 272620000621 UPF0126 domain; Region: UPF0126; pfam03458 272620000622 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 272620000623 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 272620000624 cobalamin binding residues [chemical binding]; other site 272620000625 putative BtuC binding residues; other site 272620000626 dimer interface [polypeptide binding]; other site 272620000627 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 272620000628 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 272620000629 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 272620000630 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620000631 Zn2+ binding site [ion binding]; other site 272620000632 Mg2+ binding site [ion binding]; other site 272620000633 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 272620000634 serine endoprotease; Provisional; Region: PRK10942 272620000635 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272620000636 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272620000637 protein binding site [polypeptide binding]; other site 272620000638 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272620000639 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 272620000640 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 272620000641 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272620000642 hypothetical protein; Provisional; Region: PRK13677 272620000643 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 272620000644 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 272620000645 trimer interface [polypeptide binding]; other site 272620000646 active site 272620000647 substrate binding site [chemical binding]; other site 272620000648 CoA binding site [chemical binding]; other site 272620000649 PII uridylyl-transferase; Provisional; Region: PRK05007 272620000650 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272620000651 metal binding triad; other site 272620000652 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272620000653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620000654 Zn2+ binding site [ion binding]; other site 272620000655 Mg2+ binding site [ion binding]; other site 272620000656 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 272620000657 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 272620000658 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272620000659 active site 272620000660 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272620000661 rRNA interaction site [nucleotide binding]; other site 272620000662 S8 interaction site; other site 272620000663 putative laminin-1 binding site; other site 272620000664 elongation factor Ts; Provisional; Region: tsf; PRK09377 272620000665 UBA/TS-N domain; Region: UBA; pfam00627 272620000666 Elongation factor TS; Region: EF_TS; pfam00889 272620000667 Elongation factor TS; Region: EF_TS; pfam00889 272620000668 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272620000669 putative nucleotide binding site [chemical binding]; other site 272620000670 uridine monophosphate binding site [chemical binding]; other site 272620000671 homohexameric interface [polypeptide binding]; other site 272620000672 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272620000673 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272620000674 hinge region; other site 272620000675 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272620000676 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272620000677 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272620000678 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272620000679 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 272620000680 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 272620000681 catalytic residue [active] 272620000682 putative FPP diphosphate binding site; other site 272620000683 putative FPP binding hydrophobic cleft; other site 272620000684 dimer interface [polypeptide binding]; other site 272620000685 putative IPP diphosphate binding site; other site 272620000686 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 272620000687 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272620000688 zinc metallopeptidase RseP; Provisional; Region: PRK10779 272620000689 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272620000690 active site 272620000691 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272620000692 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 272620000693 protein binding site [polypeptide binding]; other site 272620000694 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 272620000695 putative substrate binding region [chemical binding]; other site 272620000696 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 272620000697 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620000698 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620000699 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620000700 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620000701 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620000702 Surface antigen; Region: Bac_surface_Ag; pfam01103 272620000703 periplasmic chaperone; Provisional; Region: PRK10780 272620000704 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 272620000705 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 272620000706 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 272620000707 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 272620000708 trimer interface [polypeptide binding]; other site 272620000709 active site 272620000710 UDP-GlcNAc binding site [chemical binding]; other site 272620000711 lipid binding site [chemical binding]; lipid-binding site 272620000712 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 272620000713 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 272620000714 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 272620000715 active site 272620000716 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 272620000717 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 272620000718 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272620000719 RNA/DNA hybrid binding site [nucleotide binding]; other site 272620000720 active site 272620000721 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 272620000722 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 272620000723 putative active site [active] 272620000724 putative PHP Thumb interface [polypeptide binding]; other site 272620000725 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272620000726 generic binding surface II; other site 272620000727 generic binding surface I; other site 272620000728 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 272620000729 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 272620000730 lysine decarboxylase LdcC; Provisional; Region: PRK15399 272620000731 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 272620000732 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272620000733 homodimer interface [polypeptide binding]; other site 272620000734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620000735 catalytic residue [active] 272620000736 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272620000737 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 272620000738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620000739 putative metal binding site [ion binding]; other site 272620000740 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 272620000741 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272620000742 Ligand Binding Site [chemical binding]; other site 272620000743 TilS substrate binding domain; Region: TilS; pfam09179 272620000744 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 272620000745 Rho-binding antiterminator; Provisional; Region: PRK11625 272620000746 hypothetical protein; Provisional; Region: PRK04964 272620000747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 272620000748 hypothetical protein; Provisional; Region: PRK09256 272620000749 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 272620000750 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 272620000751 NlpE N-terminal domain; Region: NlpE; pfam04170 272620000752 hypothetical protein; Provisional; Region: PRK11479 272620000753 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 272620000754 prolyl-tRNA synthetase; Provisional; Region: PRK09194 272620000755 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 272620000756 dimer interface [polypeptide binding]; other site 272620000757 motif 1; other site 272620000758 active site 272620000759 motif 2; other site 272620000760 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 272620000761 putative deacylase active site [active] 272620000762 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272620000763 active site 272620000764 motif 3; other site 272620000765 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 272620000766 anticodon binding site; other site 272620000767 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 272620000768 homodimer interaction site [polypeptide binding]; other site 272620000769 cofactor binding site; other site 272620000770 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 272620000771 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 272620000772 lipoprotein, YaeC family; Region: TIGR00363 272620000773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620000774 dimer interface [polypeptide binding]; other site 272620000775 conserved gate region; other site 272620000776 ABC-ATPase subunit interface; other site 272620000777 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272620000778 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272620000779 Walker A/P-loop; other site 272620000780 ATP binding site [chemical binding]; other site 272620000781 Q-loop/lid; other site 272620000782 ABC transporter signature motif; other site 272620000783 Walker B; other site 272620000784 D-loop; other site 272620000785 H-loop/switch region; other site 272620000786 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 272620000787 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 272620000788 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620000789 active site 272620000790 motif I; other site 272620000791 motif II; other site 272620000792 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620000793 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620000794 active site 272620000795 catalytic tetrad [active] 272620000796 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620000797 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620000798 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 272620000799 putative effector binding pocket; other site 272620000800 dimerization interface [polypeptide binding]; other site 272620000801 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620000802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620000803 putative substrate translocation pore; other site 272620000804 hypothetical protein; Provisional; Region: PRK05421 272620000805 putative catalytic site [active] 272620000806 putative metal binding site [ion binding]; other site 272620000807 putative phosphate binding site [ion binding]; other site 272620000808 putative catalytic site [active] 272620000809 putative phosphate binding site [ion binding]; other site 272620000810 putative metal binding site [ion binding]; other site 272620000811 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272620000812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620000813 S-adenosylmethionine binding site [chemical binding]; other site 272620000814 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 272620000815 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620000816 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620000817 catalytic residue [active] 272620000818 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620000819 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620000820 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 272620000821 Methyltransferase domain; Region: Methyltransf_11; pfam08241 272620000822 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 272620000823 RNA/DNA hybrid binding site [nucleotide binding]; other site 272620000824 active site 272620000825 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 272620000826 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 272620000827 active site 272620000828 catalytic site [active] 272620000829 substrate binding site [chemical binding]; other site 272620000830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620000831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620000832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620000833 dimerization interface [polypeptide binding]; other site 272620000834 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 272620000835 C-N hydrolase family amidase; Provisional; Region: PRK10438 272620000836 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 272620000837 putative active site [active] 272620000838 catalytic triad [active] 272620000839 dimer interface [polypeptide binding]; other site 272620000840 multimer interface [polypeptide binding]; other site 272620000841 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 272620000842 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 272620000843 active site 272620000844 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 272620000845 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 272620000846 dimer interface [polypeptide binding]; other site 272620000847 active site 272620000848 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 272620000849 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 272620000850 putative active site [active] 272620000851 putative dimer interface [polypeptide binding]; other site 272620000852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 272620000853 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 272620000854 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272620000855 E3 interaction surface; other site 272620000856 lipoyl attachment site [posttranslational modification]; other site 272620000857 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 272620000858 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 272620000859 FMN-binding domain; Region: FMN_bind; cl01081 272620000860 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 272620000861 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 272620000862 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 272620000863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620000864 catalytic loop [active] 272620000865 iron binding site [ion binding]; other site 272620000866 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 272620000867 FAD binding pocket [chemical binding]; other site 272620000868 FAD binding motif [chemical binding]; other site 272620000869 phosphate binding motif [ion binding]; other site 272620000870 beta-alpha-beta structure motif; other site 272620000871 NAD binding pocket [chemical binding]; other site 272620000872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 272620000873 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272620000874 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272620000875 active site 272620000876 catalytic site [active] 272620000877 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272620000878 active site 272620000879 DNA polymerase IV; Validated; Region: PRK02406 272620000880 DNA binding site [nucleotide binding] 272620000881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620000882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620000883 Coenzyme A binding pocket [chemical binding]; other site 272620000884 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 272620000885 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 272620000886 metal binding site [ion binding]; metal-binding site 272620000887 dimer interface [polypeptide binding]; other site 272620000888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620000889 active site 272620000890 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 272620000891 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 272620000892 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 272620000893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620000894 DNA-binding site [nucleotide binding]; DNA binding site 272620000895 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272620000896 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 272620000897 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 272620000898 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620000899 inhibitor-cofactor binding pocket; inhibition site 272620000900 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620000901 catalytic residue [active] 272620000902 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 272620000903 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272620000904 tetramerization interface [polypeptide binding]; other site 272620000905 NAD(P) binding site [chemical binding]; other site 272620000906 catalytic residues [active] 272620000907 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272620000908 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272620000909 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 272620000910 substrate binding pocket [chemical binding]; other site 272620000911 active site 272620000912 iron coordination sites [ion binding]; other site 272620000913 hypothetical protein; Provisional; Region: PRK13687 272620000914 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272620000915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620000916 S-adenosylmethionine binding site [chemical binding]; other site 272620000917 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 272620000918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620000919 active site 272620000920 fimbrial assembly chaperone StbE; Provisional; Region: PRK15246 272620000921 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620000922 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620000923 putative fimbrial usher protein StbD; Provisional; Region: PRK15247 272620000924 fimbrial outer membrane usher protein StbC; Provisional; Region: PRK15248 272620000925 PapC N-terminal domain; Region: PapC_N; pfam13954 272620000926 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620000927 PapC C-terminal domain; Region: PapC_C; pfam13953 272620000928 fimbrial chaperone protein StbB; Provisional; Region: PRK15249 272620000929 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620000930 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620000931 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620000932 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 272620000933 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620000934 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620000935 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 272620000936 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 272620000937 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 272620000938 Transposase domain (DUF772); Region: DUF772; pfam05598 272620000939 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 272620000940 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272620000941 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272620000942 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620000943 Fimbrial protein; Region: Fimbrial; cl01416 272620000944 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620000945 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620000946 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620000947 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620000948 PapC N-terminal domain; Region: PapC_N; pfam13954 272620000949 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620000950 PapC C-terminal domain; Region: PapC_C; pfam13953 272620000951 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 272620000952 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 272620000953 putative catalytic cysteine [active] 272620000954 gamma-glutamyl kinase; Provisional; Region: PRK05429 272620000955 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 272620000956 nucleotide binding site [chemical binding]; other site 272620000957 homotetrameric interface [polypeptide binding]; other site 272620000958 putative phosphate binding site [ion binding]; other site 272620000959 putative allosteric binding site; other site 272620000960 PUA domain; Region: PUA; pfam01472 272620000961 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 272620000962 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 272620000963 trimer interface [polypeptide binding]; other site 272620000964 eyelet of channel; other site 272620000965 NlpC/P60 family; Region: NLPC_P60; pfam00877 272620000966 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272620000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272620000968 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272620000969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620000970 dimer interface [polypeptide binding]; other site 272620000971 conserved gate region; other site 272620000972 putative PBP binding loops; other site 272620000973 ABC-ATPase subunit interface; other site 272620000974 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272620000975 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272620000976 Walker A/P-loop; other site 272620000977 ATP binding site [chemical binding]; other site 272620000978 Q-loop/lid; other site 272620000979 ABC transporter signature motif; other site 272620000980 Walker B; other site 272620000981 D-loop; other site 272620000982 H-loop/switch region; other site 272620000983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620000984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620000985 DNA binding residues [nucleotide binding] 272620000986 putative fimbrial protein TcfA; Provisional; Region: PRK15308 272620000987 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620000988 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 272620000989 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620000991 dimer interface [polypeptide binding]; other site 272620000992 conserved gate region; other site 272620000993 putative PBP binding loops; other site 272620000994 ABC-ATPase subunit interface; other site 272620000995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620000996 dimer interface [polypeptide binding]; other site 272620000997 conserved gate region; other site 272620000998 putative PBP binding loops; other site 272620000999 ABC-ATPase subunit interface; other site 272620001000 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620001001 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620001002 Walker A/P-loop; other site 272620001003 ATP binding site [chemical binding]; other site 272620001004 Q-loop/lid; other site 272620001005 ABC transporter signature motif; other site 272620001006 Walker B; other site 272620001007 D-loop; other site 272620001008 H-loop/switch region; other site 272620001009 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620001010 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620001011 substrate binding pocket [chemical binding]; other site 272620001012 membrane-bound complex binding site; other site 272620001013 hinge residues; other site 272620001014 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272620001015 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272620001016 Walker A/P-loop; other site 272620001017 ATP binding site [chemical binding]; other site 272620001018 Q-loop/lid; other site 272620001019 ABC transporter signature motif; other site 272620001020 Walker B; other site 272620001021 D-loop; other site 272620001022 H-loop/switch region; other site 272620001023 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272620001024 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272620001025 Walker A/P-loop; other site 272620001026 ATP binding site [chemical binding]; other site 272620001027 Q-loop/lid; other site 272620001028 ABC transporter signature motif; other site 272620001029 Walker B; other site 272620001030 D-loop; other site 272620001031 H-loop/switch region; other site 272620001032 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 272620001033 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272620001034 TM-ABC transporter signature motif; other site 272620001035 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620001036 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272620001037 TM-ABC transporter signature motif; other site 272620001038 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272620001039 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 272620001040 putative ligand binding site [chemical binding]; other site 272620001041 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 272620001042 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 272620001043 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 272620001044 ethanolamine permease; Region: 2A0305; TIGR00908 272620001045 S-methylmethionine transporter; Provisional; Region: PRK11387 272620001046 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 272620001047 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 272620001048 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 272620001049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620001050 substrate binding pocket [chemical binding]; other site 272620001051 membrane-bound complex binding site; other site 272620001052 hinge residues; other site 272620001053 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 272620001054 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272620001055 Walker A/P-loop; other site 272620001056 ATP binding site [chemical binding]; other site 272620001057 Q-loop/lid; other site 272620001058 ABC transporter signature motif; other site 272620001059 Walker B; other site 272620001060 D-loop; other site 272620001061 H-loop/switch region; other site 272620001062 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272620001063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001064 dimer interface [polypeptide binding]; other site 272620001065 conserved gate region; other site 272620001066 putative PBP binding loops; other site 272620001067 ABC-ATPase subunit interface; other site 272620001068 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 272620001069 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 272620001070 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 272620001071 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272620001072 putative acyl-acceptor binding pocket; other site 272620001073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 272620001074 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 272620001075 dimer interface [polypeptide binding]; other site 272620001076 active site 272620001077 Schiff base residues; other site 272620001078 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 272620001079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272620001080 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272620001081 Isochorismatase family; Region: Isochorismatase; pfam00857 272620001082 catalytic triad [active] 272620001083 conserved cis-peptide bond; other site 272620001084 microcin B17 transporter; Reviewed; Region: PRK11098 272620001085 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 272620001086 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 272620001087 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 272620001088 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 272620001089 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 272620001090 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 272620001091 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 272620001092 drug efflux system protein MdtG; Provisional; Region: PRK09874 272620001093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001094 putative substrate translocation pore; other site 272620001095 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 272620001096 alkaline phosphatase; Provisional; Region: PRK10518 272620001097 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 272620001098 active site 272620001099 dimer interface [polypeptide binding]; other site 272620001100 hypothetical protein; Provisional; Region: PRK11505 272620001101 psiF repeat; Region: PsiF_repeat; pfam07769 272620001102 psiF repeat; Region: PsiF_repeat; pfam07769 272620001103 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 272620001104 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 272620001105 hypothetical protein; Validated; Region: PRK00124 272620001106 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 272620001107 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 272620001108 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272620001109 ADP binding site [chemical binding]; other site 272620001110 magnesium binding site [ion binding]; other site 272620001111 putative shikimate binding site; other site 272620001112 hypothetical protein; Provisional; Region: PRK10380 272620001113 hypothetical protein; Provisional; Region: PRK10481 272620001114 hypothetical protein; Provisional; Region: PRK10579 272620001115 recombination associated protein; Reviewed; Region: rdgC; PRK00321 272620001116 fructokinase; Reviewed; Region: PRK09557 272620001117 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620001118 nucleotide binding site [chemical binding]; other site 272620001119 Acetokinase family; Region: Acetate_kinase; cl17229 272620001120 exonuclease subunit SbcC; Provisional; Region: PRK10246 272620001121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620001122 Walker A/P-loop; other site 272620001123 ATP binding site [chemical binding]; other site 272620001124 Q-loop/lid; other site 272620001125 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620001126 ABC transporter signature motif; other site 272620001127 Walker B; other site 272620001128 D-loop; other site 272620001129 H-loop/switch region; other site 272620001130 exonuclease subunit SbcD; Provisional; Region: PRK10966 272620001131 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 272620001132 active site 272620001133 metal binding site [ion binding]; metal-binding site 272620001134 DNA binding site [nucleotide binding] 272620001135 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 272620001136 transcriptional regulator PhoB; Provisional; Region: PRK10161 272620001137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620001138 active site 272620001139 phosphorylation site [posttranslational modification] 272620001140 intermolecular recognition site; other site 272620001141 dimerization interface [polypeptide binding]; other site 272620001142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620001143 DNA binding site [nucleotide binding] 272620001144 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 272620001145 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 272620001146 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272620001147 putative active site [active] 272620001148 heme pocket [chemical binding]; other site 272620001149 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620001150 dimer interface [polypeptide binding]; other site 272620001151 phosphorylation site [posttranslational modification] 272620001152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620001153 ATP binding site [chemical binding]; other site 272620001154 Mg2+ binding site [ion binding]; other site 272620001155 G-X-G motif; other site 272620001156 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 272620001157 putative proline-specific permease; Provisional; Region: proY; PRK10580 272620001158 maltodextrin glucosidase; Provisional; Region: PRK10785 272620001159 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 272620001160 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 272620001161 active site 272620001162 homodimer interface [polypeptide binding]; other site 272620001163 catalytic site [active] 272620001164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620001165 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 272620001166 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620001167 dimerization interface [polypeptide binding]; other site 272620001168 Isochorismatase family; Region: Isochorismatase; pfam00857 272620001169 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 272620001170 catalytic triad [active] 272620001171 dimer interface [polypeptide binding]; other site 272620001172 conserved cis-peptide bond; other site 272620001173 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 272620001174 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 272620001175 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 272620001176 active site 272620001177 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272620001178 intersubunit interface [polypeptide binding]; other site 272620001179 active site 272620001180 zinc binding site [ion binding]; other site 272620001181 Na+ binding site [ion binding]; other site 272620001182 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620001183 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 272620001184 substrate binding site [chemical binding]; other site 272620001185 ATP binding site [chemical binding]; other site 272620001186 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272620001187 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272620001188 active site 272620001189 P-loop; other site 272620001190 phosphorylation site [posttranslational modification] 272620001191 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620001192 active site 272620001193 phosphorylation site [posttranslational modification] 272620001194 peroxidase; Provisional; Region: PRK15000 272620001195 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272620001196 dimer interface [polypeptide binding]; other site 272620001197 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272620001198 catalytic triad [active] 272620001199 peroxidatic and resolving cysteines [active] 272620001200 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 272620001201 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 272620001202 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 272620001203 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 272620001204 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 272620001205 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 272620001206 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 272620001207 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 272620001208 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272620001209 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 272620001210 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 272620001211 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 272620001212 Protein export membrane protein; Region: SecD_SecF; pfam02355 272620001213 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 272620001214 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620001215 Predicted transcriptional regulator [Transcription]; Region: COG2378 272620001216 HTH domain; Region: HTH_11; pfam08279 272620001217 WYL domain; Region: WYL; pfam13280 272620001218 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 272620001219 hypothetical protein; Provisional; Region: PRK11530 272620001220 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 272620001221 ATP cone domain; Region: ATP-cone; pfam03477 272620001222 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 272620001223 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 272620001224 catalytic motif [active] 272620001225 Zn binding site [ion binding]; other site 272620001226 RibD C-terminal domain; Region: RibD_C; cl17279 272620001227 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 272620001228 homopentamer interface [polypeptide binding]; other site 272620001229 active site 272620001230 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 272620001231 putative RNA binding site [nucleotide binding]; other site 272620001232 thiamine monophosphate kinase; Provisional; Region: PRK05731 272620001233 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 272620001234 ATP binding site [chemical binding]; other site 272620001235 dimerization interface [polypeptide binding]; other site 272620001236 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 272620001237 tetramer interfaces [polypeptide binding]; other site 272620001238 binuclear metal-binding site [ion binding]; other site 272620001239 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620001240 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620001241 active site 272620001242 catalytic tetrad [active] 272620001243 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272620001244 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272620001245 TPP-binding site; other site 272620001246 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272620001247 PYR/PP interface [polypeptide binding]; other site 272620001248 dimer interface [polypeptide binding]; other site 272620001249 TPP binding site [chemical binding]; other site 272620001250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272620001251 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272620001252 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272620001253 substrate binding pocket [chemical binding]; other site 272620001254 chain length determination region; other site 272620001255 substrate-Mg2+ binding site; other site 272620001256 catalytic residues [active] 272620001257 aspartate-rich region 1; other site 272620001258 active site lid residues [active] 272620001259 aspartate-rich region 2; other site 272620001260 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 272620001261 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 272620001262 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272620001263 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272620001264 Ligand Binding Site [chemical binding]; other site 272620001265 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272620001266 active site residue [active] 272620001267 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 272620001268 putative hydrophobic ligand binding site [chemical binding]; other site 272620001269 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 272620001270 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272620001271 conserved cys residue [active] 272620001272 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 272620001273 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272620001274 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272620001275 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 272620001276 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 272620001277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620001279 putative substrate translocation pore; other site 272620001280 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620001281 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620001282 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620001283 benzoate transport; Region: 2A0115; TIGR00895 272620001284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001285 putative substrate translocation pore; other site 272620001286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001287 putative substrate translocation pore; other site 272620001288 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272620001289 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 272620001290 Predicted oxidoreductase [General function prediction only]; Region: COG3573 272620001291 NIPSNAP; Region: NIPSNAP; pfam07978 272620001292 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 272620001293 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 272620001294 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 272620001295 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272620001296 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272620001297 shikimate binding site; other site 272620001298 NAD(P) binding site [chemical binding]; other site 272620001299 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 272620001300 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620001301 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620001302 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 272620001303 UbiA prenyltransferase family; Region: UbiA; pfam01040 272620001304 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 272620001305 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 272620001306 Subunit I/III interface [polypeptide binding]; other site 272620001307 Subunit III/IV interface [polypeptide binding]; other site 272620001308 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 272620001309 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 272620001310 D-pathway; other site 272620001311 Putative ubiquinol binding site [chemical binding]; other site 272620001312 Low-spin heme (heme b) binding site [chemical binding]; other site 272620001313 Putative water exit pathway; other site 272620001314 Binuclear center (heme o3/CuB) [ion binding]; other site 272620001315 K-pathway; other site 272620001316 Putative proton exit pathway; other site 272620001317 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 272620001318 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 272620001319 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 272620001320 muropeptide transporter; Reviewed; Region: ampG; PRK11902 272620001321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001322 putative substrate translocation pore; other site 272620001323 hypothetical protein; Provisional; Region: PRK11627 272620001324 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 272620001325 transcriptional regulator BolA; Provisional; Region: PRK11628 272620001326 trigger factor; Provisional; Region: tig; PRK01490 272620001327 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272620001328 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272620001329 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 272620001330 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 272620001331 oligomer interface [polypeptide binding]; other site 272620001332 active site residues [active] 272620001333 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 272620001334 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 272620001335 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620001336 Walker A motif; other site 272620001337 ATP binding site [chemical binding]; other site 272620001338 Walker B motif; other site 272620001339 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272620001340 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 272620001341 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272620001342 Found in ATP-dependent protease La (LON); Region: LON; smart00464 272620001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620001344 Walker A motif; other site 272620001345 ATP binding site [chemical binding]; other site 272620001346 Walker B motif; other site 272620001347 arginine finger; other site 272620001348 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272620001349 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272620001350 IHF dimer interface [polypeptide binding]; other site 272620001351 IHF - DNA interface [nucleotide binding]; other site 272620001352 periplasmic folding chaperone; Provisional; Region: PRK10788 272620001353 SurA N-terminal domain; Region: SurA_N_3; cl07813 272620001354 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 272620001355 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 272620001356 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 272620001357 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272620001358 active site 272620001359 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 272620001360 Ligand Binding Site [chemical binding]; other site 272620001361 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 272620001362 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 272620001363 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272620001364 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 272620001365 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620001366 active site 272620001367 motif I; other site 272620001368 motif II; other site 272620001369 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272620001370 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272620001371 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 272620001372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620001373 catalytic residue [active] 272620001374 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272620001375 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620001376 putative DNA binding site [nucleotide binding]; other site 272620001377 putative Zn2+ binding site [ion binding]; other site 272620001378 AsnC family; Region: AsnC_trans_reg; pfam01037 272620001379 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 272620001380 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272620001381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620001382 Walker A/P-loop; other site 272620001383 ATP binding site [chemical binding]; other site 272620001384 Q-loop/lid; other site 272620001385 ABC transporter signature motif; other site 272620001386 Walker B; other site 272620001387 D-loop; other site 272620001388 H-loop/switch region; other site 272620001389 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 272620001390 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272620001391 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620001392 Walker A/P-loop; other site 272620001393 ATP binding site [chemical binding]; other site 272620001394 Q-loop/lid; other site 272620001395 ABC transporter signature motif; other site 272620001396 Walker B; other site 272620001397 D-loop; other site 272620001398 H-loop/switch region; other site 272620001399 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 272620001400 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272620001401 ammonium transporter; Provisional; Region: PRK10666 272620001402 acyl-CoA thioesterase II; Provisional; Region: PRK10526 272620001403 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 272620001404 active site 272620001405 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 272620001406 catalytic triad [active] 272620001407 dimer interface [polypeptide binding]; other site 272620001408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 272620001409 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272620001410 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272620001411 DNA binding site [nucleotide binding] 272620001412 active site 272620001413 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620001414 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620001415 DNA-binding site [nucleotide binding]; DNA binding site 272620001416 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620001417 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620001418 homodimer interface [polypeptide binding]; other site 272620001419 catalytic residue [active] 272620001420 Predicted membrane protein [Function unknown]; Region: COG2364 272620001421 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272620001422 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272620001423 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 272620001424 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 272620001425 putative metal binding site [ion binding]; other site 272620001426 putative homodimer interface [polypeptide binding]; other site 272620001427 putative homotetramer interface [polypeptide binding]; other site 272620001428 putative homodimer-homodimer interface [polypeptide binding]; other site 272620001429 putative allosteric switch controlling residues; other site 272620001430 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 272620001431 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620001432 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620001433 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272620001434 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272620001435 Walker A/P-loop; other site 272620001436 ATP binding site [chemical binding]; other site 272620001437 Q-loop/lid; other site 272620001438 ABC transporter signature motif; other site 272620001439 Walker B; other site 272620001440 D-loop; other site 272620001441 H-loop/switch region; other site 272620001442 TOBE domain; Region: TOBE_2; pfam08402 272620001443 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 272620001444 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272620001445 DAK2 domain; Region: Dak2; cl03685 272620001446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001447 dimer interface [polypeptide binding]; other site 272620001448 conserved gate region; other site 272620001449 ABC-ATPase subunit interface; other site 272620001450 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272620001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001452 dimer interface [polypeptide binding]; other site 272620001453 conserved gate region; other site 272620001454 putative PBP binding loops; other site 272620001455 ABC-ATPase subunit interface; other site 272620001456 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 272620001457 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272620001458 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272620001459 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272620001460 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 272620001461 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620001462 active site turn [active] 272620001463 phosphorylation site [posttranslational modification] 272620001464 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 272620001465 trimer interface; other site 272620001466 sugar binding site [chemical binding]; other site 272620001467 lac repressor; Reviewed; Region: lacI; PRK09526 272620001468 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620001469 DNA binding site [nucleotide binding] 272620001470 domain linker motif; other site 272620001471 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 272620001472 ligand binding site [chemical binding]; other site 272620001473 dimerization interface (open form) [polypeptide binding]; other site 272620001474 dimerization interface (closed form) [polypeptide binding]; other site 272620001475 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 272620001476 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 272620001477 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272620001478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272620001479 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620001480 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620001481 DNA-binding site [nucleotide binding]; DNA binding site 272620001482 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620001483 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620001484 homodimer interface [polypeptide binding]; other site 272620001485 catalytic residue [active] 272620001486 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 272620001487 maltose O-acetyltransferase; Provisional; Region: PRK10092 272620001488 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 272620001489 active site 272620001490 substrate binding site [chemical binding]; other site 272620001491 trimer interface [polypeptide binding]; other site 272620001492 CoA binding site [chemical binding]; other site 272620001493 gene expression modulator; Provisional; Region: PRK10945 272620001494 Hha toxicity attenuator; Provisional; Region: PRK10667 272620001495 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 272620001496 Protein export membrane protein; Region: SecD_SecF; cl14618 272620001497 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 272620001498 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620001499 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 272620001500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620001501 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 272620001502 hypothetical protein; Provisional; Region: PRK11281 272620001503 M domain of GW182; Region: M_domain; pfam12938 272620001504 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 272620001505 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 272620001506 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620001507 putative transposase; Provisional; Region: PRK09857 272620001508 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620001509 hypothetical protein; Provisional; Region: PRK11038 272620001510 primosomal replication protein N''; Provisional; Region: PRK10093 272620001511 hypothetical protein; Provisional; Region: PRK10527 272620001512 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620001513 active site 272620001514 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 272620001515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620001516 Walker A motif; other site 272620001517 ATP binding site [chemical binding]; other site 272620001518 Walker B motif; other site 272620001519 arginine finger; other site 272620001520 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272620001521 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 272620001522 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 272620001523 hypothetical protein; Validated; Region: PRK00153 272620001524 recombination protein RecR; Reviewed; Region: recR; PRK00076 272620001525 RecR protein; Region: RecR; pfam02132 272620001526 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272620001527 putative active site [active] 272620001528 putative metal-binding site [ion binding]; other site 272620001529 tetramer interface [polypeptide binding]; other site 272620001530 heat shock protein 90; Provisional; Region: PRK05218 272620001531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620001532 ATP binding site [chemical binding]; other site 272620001533 Mg2+ binding site [ion binding]; other site 272620001534 G-X-G motif; other site 272620001535 adenylate kinase; Reviewed; Region: adk; PRK00279 272620001536 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272620001537 AMP-binding site [chemical binding]; other site 272620001538 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272620001539 inosine/guanosine kinase; Provisional; Region: PRK15074 272620001540 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620001541 putative cation:proton antiport protein; Provisional; Region: PRK10669 272620001542 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 272620001543 TrkA-N domain; Region: TrkA_N; pfam02254 272620001544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001545 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620001546 putative substrate translocation pore; other site 272620001547 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 272620001548 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 272620001549 active site 272620001550 metal binding site [ion binding]; metal-binding site 272620001551 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272620001552 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 272620001553 putative deacylase active site [active] 272620001554 TraB family; Region: TraB; cl12050 272620001555 copper exporting ATPase; Provisional; Region: copA; PRK10671 272620001556 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272620001557 metal-binding site [ion binding] 272620001558 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272620001559 metal-binding site [ion binding] 272620001560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620001561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620001562 motif II; other site 272620001563 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 272620001564 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 272620001565 DNA binding residues [nucleotide binding] 272620001566 dimer interface [polypeptide binding]; other site 272620001567 copper binding site [ion binding]; other site 272620001568 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 272620001569 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 272620001570 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 272620001571 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 272620001572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620001573 Walker A/P-loop; other site 272620001574 ATP binding site [chemical binding]; other site 272620001575 Q-loop/lid; other site 272620001576 ABC transporter signature motif; other site 272620001577 Walker B; other site 272620001578 D-loop; other site 272620001579 H-loop/switch region; other site 272620001580 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 272620001581 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 272620001582 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 272620001583 oxidoreductase; Provisional; Region: PRK08017 272620001584 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272620001585 NADP binding site [chemical binding]; other site 272620001586 active site 272620001587 steroid binding site; other site 272620001588 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 272620001589 active site 272620001590 catalytic triad [active] 272620001591 oxyanion hole [active] 272620001592 switch loop; other site 272620001593 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 272620001594 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272620001595 Walker A/P-loop; other site 272620001596 ATP binding site [chemical binding]; other site 272620001597 Q-loop/lid; other site 272620001598 ABC transporter signature motif; other site 272620001599 Walker B; other site 272620001600 D-loop; other site 272620001601 H-loop/switch region; other site 272620001602 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 272620001603 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 272620001604 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 272620001605 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272620001606 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 272620001607 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 272620001608 active site residue [active] 272620001609 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 272620001610 ATP-grasp domain; Region: ATP-grasp; pfam02222 272620001611 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 272620001612 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 272620001613 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272620001614 putative active site [active] 272620001615 putative metal binding site [ion binding]; other site 272620001616 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 272620001617 substrate binding site [chemical binding]; other site 272620001618 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272620001619 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272620001620 active site 272620001621 HIGH motif; other site 272620001622 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272620001623 KMSKS motif; other site 272620001624 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 272620001625 tRNA binding surface [nucleotide binding]; other site 272620001626 anticodon binding site; other site 272620001627 ribosome-associated protein; Provisional; Region: PRK11507 272620001628 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 272620001629 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272620001630 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272620001631 homodimer interface [polypeptide binding]; other site 272620001632 NADP binding site [chemical binding]; other site 272620001633 substrate binding site [chemical binding]; other site 272620001634 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 272620001635 active site 272620001636 homotetramer interface [polypeptide binding]; other site 272620001637 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272620001638 dimer interface [polypeptide binding]; other site 272620001639 Citrate synthase; Region: Citrate_synt; pfam00285 272620001640 active site 272620001641 citrylCoA binding site [chemical binding]; other site 272620001642 NADH binding [chemical binding]; other site 272620001643 cationic pore residues; other site 272620001644 oxalacetate/citrate binding site [chemical binding]; other site 272620001645 coenzyme A binding site [chemical binding]; other site 272620001646 catalytic triad [active] 272620001647 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 272620001648 DNA binding residues [nucleotide binding] 272620001649 dimerization interface [polypeptide binding]; other site 272620001650 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620001651 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620001652 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620001653 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620001654 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620001655 PapC N-terminal domain; Region: PapC_N; pfam13954 272620001656 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620001657 PapC C-terminal domain; Region: PapC_C; pfam13953 272620001658 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620001659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620001660 Coenzyme A binding pocket [chemical binding]; other site 272620001661 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 272620001662 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272620001663 putative acyl-acceptor binding pocket; other site 272620001664 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620001665 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 272620001666 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620001667 DNA binding site [nucleotide binding] 272620001668 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 272620001669 lysine decarboxylase CadA; Provisional; Region: PRK15400 272620001670 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 272620001671 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272620001672 homodimer interface [polypeptide binding]; other site 272620001673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620001674 catalytic residue [active] 272620001675 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272620001676 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272620001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001678 putative substrate translocation pore; other site 272620001679 POT family; Region: PTR2; pfam00854 272620001680 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 272620001681 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272620001682 dimer interface [polypeptide binding]; other site 272620001683 putative anticodon binding site; other site 272620001684 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272620001685 motif 1; other site 272620001686 active site 272620001687 motif 2; other site 272620001688 motif 3; other site 272620001689 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272620001690 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 272620001691 Metal-binding active site; metal-binding site 272620001692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620001693 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620001694 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620001695 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620001696 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620001697 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620001698 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620001699 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620001700 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620001701 DNA binding site [nucleotide binding] 272620001702 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 272620001703 putative ligand binding site [chemical binding]; other site 272620001704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620001705 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 272620001706 putative ligand binding site [chemical binding]; other site 272620001707 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620001708 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620001709 Walker A/P-loop; other site 272620001710 ATP binding site [chemical binding]; other site 272620001711 Q-loop/lid; other site 272620001712 ABC transporter signature motif; other site 272620001713 Walker B; other site 272620001714 D-loop; other site 272620001715 H-loop/switch region; other site 272620001716 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620001717 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620001718 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620001719 TM-ABC transporter signature motif; other site 272620001720 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 272620001721 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620001722 DNA binding site [nucleotide binding] 272620001723 domain linker motif; other site 272620001724 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 272620001725 dimerization interface [polypeptide binding]; other site 272620001726 ligand binding site [chemical binding]; other site 272620001727 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 272620001728 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272620001729 substrate binding [chemical binding]; other site 272620001730 active site 272620001731 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272620001732 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272620001733 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620001734 active site turn [active] 272620001735 phosphorylation site [posttranslational modification] 272620001736 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620001737 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 272620001738 trimer interface; other site 272620001739 sugar binding site [chemical binding]; other site 272620001740 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620001741 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 272620001742 putative substrate binding site [chemical binding]; other site 272620001743 putative ATP binding site [chemical binding]; other site 272620001744 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272620001745 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620001746 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620001747 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272620001748 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620001749 Walker A/P-loop; other site 272620001750 ATP binding site [chemical binding]; other site 272620001751 Q-loop/lid; other site 272620001752 ABC transporter signature motif; other site 272620001753 Walker B; other site 272620001754 D-loop; other site 272620001755 H-loop/switch region; other site 272620001756 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620001757 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620001758 ABC-ATPase subunit interface; other site 272620001759 dimer interface [polypeptide binding]; other site 272620001760 putative PBP binding regions; other site 272620001761 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 272620001762 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272620001763 intersubunit interface [polypeptide binding]; other site 272620001764 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272620001765 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272620001766 metal binding site [ion binding]; metal-binding site 272620001767 putative dimer interface [polypeptide binding]; other site 272620001768 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 272620001769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620001770 substrate binding pocket [chemical binding]; other site 272620001771 membrane-bound complex binding site; other site 272620001772 hinge residues; other site 272620001773 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620001774 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620001775 active site 272620001776 catalytic tetrad [active] 272620001777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272620001778 classical (c) SDRs; Region: SDR_c; cd05233 272620001779 NAD(P) binding site [chemical binding]; other site 272620001780 active site 272620001781 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 272620001782 Sulfatase; Region: Sulfatase; pfam00884 272620001783 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 272620001784 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620001785 FeS/SAM binding site; other site 272620001786 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272620001787 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620001788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620001789 DNA binding residues [nucleotide binding] 272620001790 dimerization interface [polypeptide binding]; other site 272620001791 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 272620001792 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 272620001793 active site 272620001794 Zn binding site [ion binding]; other site 272620001795 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 272620001796 Amino acid permease; Region: AA_permease_2; pfam13520 272620001797 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 272620001798 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272620001799 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272620001800 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272620001801 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272620001802 NAD(P) binding site [chemical binding]; other site 272620001803 catalytic residues [active] 272620001804 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272620001805 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620001806 N-terminal plug; other site 272620001807 ligand-binding site [chemical binding]; other site 272620001808 phenylalanine transporter; Provisional; Region: PRK10249 272620001809 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 272620001810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620001811 putative substrate translocation pore; other site 272620001812 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272620001813 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 272620001814 Metal-binding active site; metal-binding site 272620001815 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 272620001816 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620001817 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620001818 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620001819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620001820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620001821 DNA binding site [nucleotide binding] 272620001822 domain linker motif; other site 272620001823 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 272620001824 dimerization interface [polypeptide binding]; other site 272620001825 ligand binding site [chemical binding]; other site 272620001826 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272620001827 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620001828 Helix-turn-helix domain; Region: HTH_31; pfam13560 272620001829 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272620001830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620001831 ATP binding site [chemical binding]; other site 272620001832 Walker B motif; other site 272620001833 arginine finger; other site 272620001834 Transcriptional antiterminator [Transcription]; Region: COG3933 272620001835 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620001836 active pocket/dimerization site; other site 272620001837 active site 272620001838 phosphorylation site [posttranslational modification] 272620001839 PRD domain; Region: PRD; pfam00874 272620001840 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272620001841 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 272620001842 putative active site [active] 272620001843 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272620001844 dimer interface [polypeptide binding]; other site 272620001845 active site 272620001846 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272620001847 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272620001848 dimer interface [polypeptide binding]; other site 272620001849 active site 272620001850 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272620001851 dimer interface [polypeptide binding]; other site 272620001852 active site 272620001853 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272620001854 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 272620001855 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 272620001856 active site 272620001857 phosphorylation site [posttranslational modification] 272620001858 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620001859 active site 272620001860 active pocket/dimerization site; other site 272620001861 phosphorylation site [posttranslational modification] 272620001862 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 272620001863 dimer interface [polypeptide binding]; other site 272620001864 FMN binding site [chemical binding]; other site 272620001865 hypothetical protein; Provisional; Region: PRK10250 272620001866 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620001867 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620001868 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 272620001869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620001870 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 272620001871 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272620001872 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272620001873 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620001874 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272620001875 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272620001876 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272620001877 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272620001878 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272620001879 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620001880 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620001881 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272620001882 Predicted periplasmic protein [Function unknown]; Region: COG3698 272620001883 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 272620001884 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 272620001885 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 272620001886 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 272620001887 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 272620001888 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272620001889 Protein of unknown function (DUF419); Region: DUF419; cl15265 272620001890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001891 dimer interface [polypeptide binding]; other site 272620001892 conserved gate region; other site 272620001893 putative PBP binding loops; other site 272620001894 ABC-ATPase subunit interface; other site 272620001895 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 272620001896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272620001897 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272620001898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620001899 Walker A/P-loop; other site 272620001900 ATP binding site [chemical binding]; other site 272620001901 Q-loop/lid; other site 272620001902 ABC transporter signature motif; other site 272620001903 Walker B; other site 272620001904 D-loop; other site 272620001905 H-loop/switch region; other site 272620001906 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272620001907 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272620001908 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620001909 Walker A/P-loop; other site 272620001910 ATP binding site [chemical binding]; other site 272620001911 Q-loop/lid; other site 272620001912 ABC transporter signature motif; other site 272620001913 Walker B; other site 272620001914 D-loop; other site 272620001915 H-loop/switch region; other site 272620001916 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620001917 allantoate amidohydrolase; Reviewed; Region: PRK12893 272620001918 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272620001919 active site 272620001920 metal binding site [ion binding]; metal-binding site 272620001921 dimer interface [polypeptide binding]; other site 272620001922 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620001923 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620001924 DNA-binding site [nucleotide binding]; DNA binding site 272620001925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620001926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620001927 homodimer interface [polypeptide binding]; other site 272620001928 catalytic residue [active] 272620001929 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620001930 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620001931 DNA-binding site [nucleotide binding]; DNA binding site 272620001932 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620001933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620001934 homodimer interface [polypeptide binding]; other site 272620001935 catalytic residue [active] 272620001936 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620001937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620001938 substrate binding pocket [chemical binding]; other site 272620001939 membrane-bound complex binding site; other site 272620001940 hinge residues; other site 272620001941 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620001942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001943 dimer interface [polypeptide binding]; other site 272620001944 conserved gate region; other site 272620001945 putative PBP binding loops; other site 272620001946 ABC-ATPase subunit interface; other site 272620001947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001948 dimer interface [polypeptide binding]; other site 272620001949 conserved gate region; other site 272620001950 putative PBP binding loops; other site 272620001951 ABC-ATPase subunit interface; other site 272620001952 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620001953 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620001954 Walker A/P-loop; other site 272620001955 ATP binding site [chemical binding]; other site 272620001956 Q-loop/lid; other site 272620001957 ABC transporter signature motif; other site 272620001958 Walker B; other site 272620001959 D-loop; other site 272620001960 H-loop/switch region; other site 272620001961 malonic semialdehyde reductase; Provisional; Region: PRK10538 272620001962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620001963 NAD(P) binding site [chemical binding]; other site 272620001964 active site 272620001965 hypothetical protein; Provisional; Region: PRK06062 272620001966 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620001967 inhibitor-cofactor binding pocket; inhibition site 272620001968 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620001969 catalytic residue [active] 272620001970 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272620001971 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620001972 Walker A/P-loop; other site 272620001973 ATP binding site [chemical binding]; other site 272620001974 Q-loop/lid; other site 272620001975 ABC transporter signature motif; other site 272620001976 Walker B; other site 272620001977 D-loop; other site 272620001978 H-loop/switch region; other site 272620001979 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272620001980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620001981 Walker A/P-loop; other site 272620001982 ATP binding site [chemical binding]; other site 272620001983 Q-loop/lid; other site 272620001984 ABC transporter signature motif; other site 272620001985 Walker B; other site 272620001986 D-loop; other site 272620001987 H-loop/switch region; other site 272620001988 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272620001989 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620001990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001991 dimer interface [polypeptide binding]; other site 272620001992 conserved gate region; other site 272620001993 ABC-ATPase subunit interface; other site 272620001994 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272620001995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620001996 dimer interface [polypeptide binding]; other site 272620001997 conserved gate region; other site 272620001998 putative PBP binding loops; other site 272620001999 ABC-ATPase subunit interface; other site 272620002000 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620002001 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 272620002002 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272620002003 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620002004 choline dehydrogenase; Validated; Region: PRK02106 272620002005 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272620002006 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 272620002007 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 272620002008 tetrameric interface [polypeptide binding]; other site 272620002009 NAD binding site [chemical binding]; other site 272620002010 catalytic residues [active] 272620002011 transcriptional regulator BetI; Validated; Region: PRK00767 272620002012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620002013 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272620002014 choline transport protein BetT; Provisional; Region: PRK09928 272620002015 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272620002016 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620002017 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272620002018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620002019 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620002020 dimerization interface [polypeptide binding]; other site 272620002021 substrate binding pocket [chemical binding]; other site 272620002022 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272620002023 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272620002024 C-terminal domain interface [polypeptide binding]; other site 272620002025 GSH binding site (G-site) [chemical binding]; other site 272620002026 dimer interface [polypeptide binding]; other site 272620002027 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 272620002028 dimer interface [polypeptide binding]; other site 272620002029 N-terminal domain interface [polypeptide binding]; other site 272620002030 putative substrate binding pocket (H-site) [chemical binding]; other site 272620002031 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 272620002032 N- and C-terminal domain interface [polypeptide binding]; other site 272620002033 glycerol kinase; Region: glycerol_kin; TIGR01311 272620002034 active site 272620002035 MgATP binding site [chemical binding]; other site 272620002036 catalytic site [active] 272620002037 metal binding site [ion binding]; metal-binding site 272620002038 putative homotetramer interface [polypeptide binding]; other site 272620002039 putative homodimer interface [polypeptide binding]; other site 272620002040 glycerol binding site [chemical binding]; other site 272620002041 L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407 272620002042 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 272620002043 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272620002044 substrate binding site [chemical binding]; other site 272620002045 trimer interface [polypeptide binding]; other site 272620002046 Mn binding site [ion binding]; other site 272620002047 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 272620002048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272620002049 PYR/PP interface [polypeptide binding]; other site 272620002050 dimer interface [polypeptide binding]; other site 272620002051 TPP binding site [chemical binding]; other site 272620002052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272620002053 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272620002054 TPP-binding site [chemical binding]; other site 272620002055 dimer interface [polypeptide binding]; other site 272620002056 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272620002057 MarR family; Region: MarR_2; cl17246 272620002058 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272620002059 hypothetical protein; Provisional; Region: PRK09956 272620002060 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620002061 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620002062 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620002063 TM-ABC transporter signature motif; other site 272620002064 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620002065 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620002066 Walker A/P-loop; other site 272620002067 ATP binding site [chemical binding]; other site 272620002068 Q-loop/lid; other site 272620002069 ABC transporter signature motif; other site 272620002070 Walker B; other site 272620002071 D-loop; other site 272620002072 H-loop/switch region; other site 272620002073 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620002074 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; pfam10054 272620002075 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620002076 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272620002077 ligand binding site [chemical binding]; other site 272620002078 dimerization interface [polypeptide binding]; other site 272620002079 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 272620002080 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 272620002081 outer membrane receptor FepA; Provisional; Region: PRK13524 272620002082 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620002083 N-terminal plug; other site 272620002084 ligand-binding site [chemical binding]; other site 272620002085 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 272620002086 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 272620002087 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272620002088 MbtH-like protein; Region: MbtH; cl01279 272620002089 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 272620002090 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 272620002091 acyl-activating enzyme (AAE) consensus motif; other site 272620002092 AMP binding site [chemical binding]; other site 272620002093 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272620002094 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 272620002095 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620002096 Walker A/P-loop; other site 272620002097 ATP binding site [chemical binding]; other site 272620002098 Q-loop/lid; other site 272620002099 ABC transporter signature motif; other site 272620002100 Walker B; other site 272620002101 D-loop; other site 272620002102 H-loop/switch region; other site 272620002103 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 272620002104 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620002105 ABC-ATPase subunit interface; other site 272620002106 dimer interface [polypeptide binding]; other site 272620002107 putative PBP binding regions; other site 272620002108 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620002109 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620002110 ABC-ATPase subunit interface; other site 272620002111 dimer interface [polypeptide binding]; other site 272620002112 putative PBP binding regions; other site 272620002113 enterobactin exporter EntS; Provisional; Region: PRK10489 272620002114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002115 putative substrate translocation pore; other site 272620002116 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 272620002117 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272620002118 siderophore binding site; other site 272620002119 isochorismate synthase EntC; Provisional; Region: PRK15016 272620002120 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272620002121 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 272620002122 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 272620002123 acyl-activating enzyme (AAE) consensus motif; other site 272620002124 active site 272620002125 AMP binding site [chemical binding]; other site 272620002126 substrate binding site [chemical binding]; other site 272620002127 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 272620002128 hydrophobic substrate binding pocket; other site 272620002129 Isochorismatase family; Region: Isochorismatase; pfam00857 272620002130 active site 272620002131 conserved cis-peptide bond; other site 272620002132 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 272620002133 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 272620002134 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 272620002135 putative NAD(P) binding site [chemical binding]; other site 272620002136 active site 272620002137 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272620002138 CoenzymeA binding site [chemical binding]; other site 272620002139 subunit interaction site [polypeptide binding]; other site 272620002140 PHB binding site; other site 272620002141 carbon starvation protein A; Provisional; Region: PRK15015 272620002142 Carbon starvation protein CstA; Region: CstA; pfam02554 272620002143 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272620002144 Uncharacterized small protein [Function unknown]; Region: COG2879 272620002145 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620002146 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620002147 salt bridge; other site 272620002148 non-specific DNA binding site [nucleotide binding]; other site 272620002149 sequence-specific DNA binding site [nucleotide binding]; other site 272620002150 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272620002151 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272620002152 classical (c) SDRs; Region: SDR_c; cd05233 272620002153 NAD(P) binding site [chemical binding]; other site 272620002154 active site 272620002155 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 272620002156 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 272620002157 putative active site [active] 272620002158 metal binding site [ion binding]; metal-binding site 272620002159 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620002160 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620002161 Walker A/P-loop; other site 272620002162 ATP binding site [chemical binding]; other site 272620002163 Q-loop/lid; other site 272620002164 ABC transporter signature motif; other site 272620002165 Walker B; other site 272620002166 D-loop; other site 272620002167 H-loop/switch region; other site 272620002168 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620002169 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620002170 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620002171 TM-ABC transporter signature motif; other site 272620002172 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 272620002173 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272620002174 putative ligand binding site [chemical binding]; other site 272620002175 Uncharacterized conserved protein [Function unknown]; Region: COG5276 272620002176 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 272620002177 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 272620002178 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 272620002179 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 272620002180 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 272620002181 catalytic core [active] 272620002182 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 272620002183 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272620002184 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002185 putative substrate translocation pore; other site 272620002186 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272620002187 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272620002188 active site 272620002189 dimerization interface [polypeptide binding]; other site 272620002190 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620002191 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620002192 DNA binding site [nucleotide binding] 272620002193 domain linker motif; other site 272620002194 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 272620002195 putative dimerization interface [polypeptide binding]; other site 272620002196 putative ligand binding site [chemical binding]; other site 272620002197 cytosine deaminase; Provisional; Region: PRK09230 272620002198 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 272620002199 active site 272620002200 cytosine permease; Provisional; Region: codB; PRK11017 272620002201 Na binding site [ion binding]; other site 272620002202 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 272620002203 intersubunit interface [polypeptide binding]; other site 272620002204 active site 272620002205 Zn2+ binding site [ion binding]; other site 272620002206 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 272620002207 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 272620002208 putative N- and C-terminal domain interface [polypeptide binding]; other site 272620002209 putative active site [active] 272620002210 MgATP binding site [chemical binding]; other site 272620002211 catalytic site [active] 272620002212 metal binding site [ion binding]; metal-binding site 272620002213 putative xylulose binding site [chemical binding]; other site 272620002214 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272620002215 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 272620002216 putative ligand binding site [chemical binding]; other site 272620002217 putative NAD binding site [chemical binding]; other site 272620002218 catalytic site [active] 272620002219 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620002220 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272620002221 substrate binding site [chemical binding]; other site 272620002222 ATP binding site [chemical binding]; other site 272620002223 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620002224 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620002225 TM-ABC transporter signature motif; other site 272620002226 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620002227 TM-ABC transporter signature motif; other site 272620002228 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620002229 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620002230 Walker A/P-loop; other site 272620002231 ATP binding site [chemical binding]; other site 272620002232 Q-loop/lid; other site 272620002233 ABC transporter signature motif; other site 272620002234 Walker B; other site 272620002235 D-loop; other site 272620002236 H-loop/switch region; other site 272620002237 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620002238 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 272620002239 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272620002240 putative ligand binding site [chemical binding]; other site 272620002241 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 272620002242 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 272620002243 molybdopterin cofactor binding site [chemical binding]; other site 272620002244 substrate binding site [chemical binding]; other site 272620002245 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 272620002246 molybdopterin cofactor binding site; other site 272620002247 ARD/ARD' family; Region: ARD; pfam03079 272620002248 Cupin domain; Region: Cupin_2; cl17218 272620002249 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 272620002250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002251 motif II; other site 272620002252 methionine aminotransferase; Validated; Region: PRK09082 272620002253 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620002254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620002255 homodimer interface [polypeptide binding]; other site 272620002256 catalytic residue [active] 272620002257 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272620002258 ParB-like nuclease domain; Region: ParBc; pfam02195 272620002259 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 272620002260 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272620002261 Active Sites [active] 272620002262 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 272620002263 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 272620002264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620002265 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620002266 dimerization interface [polypeptide binding]; other site 272620002267 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 272620002268 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 272620002269 dimerization domain [polypeptide binding]; other site 272620002270 dimer interface [polypeptide binding]; other site 272620002271 catalytic residues [active] 272620002272 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 272620002273 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 272620002274 dimer interface [polypeptide binding]; other site 272620002275 decamer (pentamer of dimers) interface [polypeptide binding]; other site 272620002276 catalytic triad [active] 272620002277 peroxidatic and resolving cysteines [active] 272620002278 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 272620002279 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 272620002280 catalytic residue [active] 272620002281 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 272620002282 catalytic residues [active] 272620002283 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620002284 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620002285 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620002286 Ligand Binding Site [chemical binding]; other site 272620002287 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 272620002288 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272620002289 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 272620002290 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 272620002291 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 272620002292 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272620002293 DNA-binding site [nucleotide binding]; DNA binding site 272620002294 RNA-binding motif; other site 272620002295 chromosome condensation membrane protein; Provisional; Region: PRK14196 272620002296 Predicted amidohydrolase [General function prediction only]; Region: COG0388 272620002297 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 272620002298 putative active site [active] 272620002299 catalytic triad [active] 272620002300 putative dimer interface [polypeptide binding]; other site 272620002301 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 272620002302 lipoyl synthase; Provisional; Region: PRK05481 272620002303 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620002304 FeS/SAM binding site; other site 272620002305 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 272620002306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620002307 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 272620002308 substrate binding pocket [chemical binding]; other site 272620002309 dimerization interface [polypeptide binding]; other site 272620002310 lipoate-protein ligase B; Provisional; Region: PRK14342 272620002311 hypothetical protein; Provisional; Region: PRK04998 272620002312 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 272620002313 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272620002314 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272620002315 rare lipoprotein A; Provisional; Region: PRK10672 272620002316 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 272620002317 Sporulation related domain; Region: SPOR; pfam05036 272620002318 cell wall shape-determining protein; Provisional; Region: PRK10794 272620002319 penicillin-binding protein 2; Provisional; Region: PRK10795 272620002320 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272620002321 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272620002322 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 272620002323 ribosome-associated protein; Provisional; Region: PRK11538 272620002324 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272620002325 catalytic core [active] 272620002326 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 272620002327 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272620002328 active site 272620002329 (T/H)XGH motif; other site 272620002330 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 272620002331 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 272620002332 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 272620002333 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272620002334 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272620002335 HIGH motif; other site 272620002336 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272620002337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272620002338 active site 272620002339 KMSKS motif; other site 272620002340 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272620002341 tRNA binding surface [nucleotide binding]; other site 272620002342 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272620002343 hypothetical protein; Provisional; Region: PRK11032 272620002344 haemagglutination activity domain; Region: Haemagg_act; pfam05860 272620002345 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 272620002346 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 272620002347 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 272620002348 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620002349 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620002350 Walker A/P-loop; other site 272620002351 ATP binding site [chemical binding]; other site 272620002352 Q-loop/lid; other site 272620002353 ABC transporter signature motif; other site 272620002354 Walker B; other site 272620002355 D-loop; other site 272620002356 H-loop/switch region; other site 272620002357 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620002358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620002359 dimer interface [polypeptide binding]; other site 272620002360 conserved gate region; other site 272620002361 putative PBP binding loops; other site 272620002362 ABC-ATPase subunit interface; other site 272620002363 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620002364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620002365 dimer interface [polypeptide binding]; other site 272620002366 conserved gate region; other site 272620002367 putative PBP binding loops; other site 272620002368 ABC-ATPase subunit interface; other site 272620002369 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 272620002370 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620002371 substrate binding pocket [chemical binding]; other site 272620002372 membrane-bound complex binding site; other site 272620002373 hinge residues; other site 272620002374 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 272620002375 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 272620002376 putative active site [active] 272620002377 catalytic triad [active] 272620002378 putative dimer interface [polypeptide binding]; other site 272620002379 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 272620002380 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272620002381 Transporter associated domain; Region: CorC_HlyC; smart01091 272620002382 metal-binding heat shock protein; Provisional; Region: PRK00016 272620002383 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272620002384 PhoH-like protein; Region: PhoH; pfam02562 272620002385 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 272620002386 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272620002387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620002388 FeS/SAM binding site; other site 272620002389 TRAM domain; Region: TRAM; pfam01938 272620002390 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 272620002391 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272620002392 asparagine synthetase B; Provisional; Region: asnB; PRK09431 272620002393 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 272620002394 active site 272620002395 dimer interface [polypeptide binding]; other site 272620002396 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 272620002397 Ligand Binding Site [chemical binding]; other site 272620002398 Molecular Tunnel; other site 272620002399 UMP phosphatase; Provisional; Region: PRK10444 272620002400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002401 active site 272620002402 motif I; other site 272620002403 motif II; other site 272620002404 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002405 MarR family; Region: MarR; pfam01047 272620002406 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272620002407 ROK family; Region: ROK; pfam00480 272620002408 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 272620002409 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272620002410 active site 272620002411 dimer interface [polypeptide binding]; other site 272620002412 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272620002413 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272620002414 active site 272620002415 trimer interface [polypeptide binding]; other site 272620002416 allosteric site; other site 272620002417 active site lid [active] 272620002418 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272620002419 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 272620002420 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620002421 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620002422 active site turn [active] 272620002423 phosphorylation site [posttranslational modification] 272620002424 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272620002425 HPr interaction site; other site 272620002426 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272620002427 active site 272620002428 phosphorylation site [posttranslational modification] 272620002429 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 272620002430 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272620002431 active site 272620002432 HIGH motif; other site 272620002433 nucleotide binding site [chemical binding]; other site 272620002434 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 272620002435 KMSKS motif; other site 272620002436 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 272620002437 outer membrane porin, OprD family; Region: OprD; pfam03573 272620002438 YbfN-like lipoprotein; Region: YbfN; pfam13982 272620002439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002440 ferric uptake regulator; Provisional; Region: fur; PRK09462 272620002441 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272620002442 metal binding site 2 [ion binding]; metal-binding site 272620002443 putative DNA binding helix; other site 272620002444 metal binding site 1 [ion binding]; metal-binding site 272620002445 dimer interface [polypeptide binding]; other site 272620002446 structural Zn2+ binding site [ion binding]; other site 272620002447 flavodoxin FldA; Validated; Region: PRK09267 272620002448 LexA regulated protein; Provisional; Region: PRK11675 272620002449 acyl-CoA esterase; Provisional; Region: PRK10673 272620002450 PGAP1-like protein; Region: PGAP1; pfam07819 272620002451 replication initiation regulator SeqA; Provisional; Region: PRK11187 272620002452 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 272620002453 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 272620002454 active site 272620002455 substrate binding site [chemical binding]; other site 272620002456 metal binding site [ion binding]; metal-binding site 272620002457 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 272620002458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620002459 active site 272620002460 phosphorylation site [posttranslational modification] 272620002461 intermolecular recognition site; other site 272620002462 dimerization interface [polypeptide binding]; other site 272620002463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620002464 DNA binding site [nucleotide binding] 272620002465 sensor protein KdpD; Provisional; Region: PRK10490 272620002466 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 272620002467 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 272620002468 Ligand Binding Site [chemical binding]; other site 272620002469 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 272620002470 GAF domain; Region: GAF_3; pfam13492 272620002471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620002472 dimer interface [polypeptide binding]; other site 272620002473 phosphorylation site [posttranslational modification] 272620002474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620002475 ATP binding site [chemical binding]; other site 272620002476 Mg2+ binding site [ion binding]; other site 272620002477 G-X-G motif; other site 272620002478 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 272620002479 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 272620002480 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620002481 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 272620002482 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 272620002483 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 272620002484 DNA photolyase; Region: DNA_photolyase; pfam00875 272620002485 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 272620002486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002487 putative substrate translocation pore; other site 272620002488 POT family; Region: PTR2; pfam00854 272620002489 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272620002490 metal-binding protein; Provisional; Region: PRK10799 272620002491 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 272620002492 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 272620002493 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 272620002494 LamB/YcsF family protein; Provisional; Region: PRK05406 272620002495 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 272620002496 putative substrate binding pocket [chemical binding]; other site 272620002497 AC domain interface; other site 272620002498 catalytic triad [active] 272620002499 AB domain interface; other site 272620002500 interchain disulfide; other site 272620002501 endonuclease VIII; Provisional; Region: PRK10445 272620002502 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 272620002503 DNA binding site [nucleotide binding] 272620002504 catalytic residue [active] 272620002505 putative catalytic residues [active] 272620002506 H2TH interface [polypeptide binding]; other site 272620002507 intercalation triad [nucleotide binding]; other site 272620002508 substrate specificity determining residue; other site 272620002509 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272620002510 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272620002511 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 272620002512 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 272620002513 dimer interface [polypeptide binding]; other site 272620002514 active site 272620002515 citrylCoA binding site [chemical binding]; other site 272620002516 NADH binding [chemical binding]; other site 272620002517 cationic pore residues; other site 272620002518 oxalacetate/citrate binding site [chemical binding]; other site 272620002519 coenzyme A binding site [chemical binding]; other site 272620002520 catalytic triad [active] 272620002521 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 272620002522 SdhD (CybS) interface [polypeptide binding]; other site 272620002523 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 272620002524 SdhC subunit interface [polypeptide binding]; other site 272620002525 proximal heme binding site [chemical binding]; other site 272620002526 cardiolipin binding site; other site 272620002527 Iron-sulfur protein interface; other site 272620002528 proximal quinone binding site [chemical binding]; other site 272620002529 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 272620002530 L-aspartate oxidase; Provisional; Region: PRK06175 272620002531 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272620002532 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 272620002533 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272620002534 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 272620002535 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 272620002536 TPP-binding site [chemical binding]; other site 272620002537 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 272620002538 dimer interface [polypeptide binding]; other site 272620002539 PYR/PP interface [polypeptide binding]; other site 272620002540 TPP binding site [chemical binding]; other site 272620002541 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 272620002542 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272620002543 E3 interaction surface; other site 272620002544 lipoyl attachment site [posttranslational modification]; other site 272620002545 e3 binding domain; Region: E3_binding; pfam02817 272620002546 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272620002547 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 272620002548 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 272620002549 CoA-ligase; Region: Ligase_CoA; pfam00549 272620002550 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 272620002551 CoA binding domain; Region: CoA_binding; smart00881 272620002552 CoA-ligase; Region: Ligase_CoA; pfam00549 272620002553 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 272620002554 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 272620002555 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 272620002556 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272620002557 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 272620002558 hypothetical protein; Provisional; Region: PRK10588 272620002559 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 272620002560 active site 272620002561 colicin uptake protein TolQ; Provisional; Region: PRK10801 272620002562 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272620002563 colicin uptake protein TolR; Provisional; Region: PRK11024 272620002564 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 272620002565 TolA C-terminal; Region: TolA; pfam06519 272620002566 translocation protein TolB; Provisional; Region: tolB; PRK03629 272620002567 TolB amino-terminal domain; Region: TolB_N; pfam04052 272620002568 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272620002569 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272620002570 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272620002571 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 272620002572 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620002573 ligand binding site [chemical binding]; other site 272620002574 tol-pal system protein YbgF; Provisional; Region: PRK10803 272620002575 Tetratricopeptide repeat; Region: TPR_6; pfam13174 272620002576 Tetratricopeptide repeat; Region: TPR_6; pfam13174 272620002577 quinolinate synthetase; Provisional; Region: PRK09375 272620002578 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 272620002579 zinc transporter ZitB; Provisional; Region: PRK03557 272620002580 YbgS-like protein; Region: YbgS; pfam13985 272620002581 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 272620002582 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272620002583 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 272620002584 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272620002585 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 272620002586 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 272620002587 fumarate hydratase; Provisional; Region: PRK06246 272620002588 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620002589 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620002590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620002591 dimerization interface [polypeptide binding]; other site 272620002592 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620002593 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620002594 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272620002595 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 272620002596 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 272620002597 transmembrane helices; other site 272620002598 oxaloacetate decarboxylase; Provisional; Region: PRK14040 272620002599 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272620002600 active site 272620002601 catalytic residues [active] 272620002602 metal binding site [ion binding]; metal-binding site 272620002603 homodimer binding site [polypeptide binding]; other site 272620002604 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272620002605 carboxyltransferase (CT) interaction site; other site 272620002606 biotinylation site [posttranslational modification]; other site 272620002607 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 272620002608 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 272620002609 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272620002610 catalytic core [active] 272620002611 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272620002612 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 272620002613 active site 272620002614 catalytic residues [active] 272620002615 galactokinase; Provisional; Region: PRK05101 272620002616 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 272620002617 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272620002618 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272620002619 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 272620002620 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 272620002621 dimer interface [polypeptide binding]; other site 272620002622 active site 272620002623 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 272620002624 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272620002625 NAD binding site [chemical binding]; other site 272620002626 homodimer interface [polypeptide binding]; other site 272620002627 active site 272620002628 substrate binding site [chemical binding]; other site 272620002629 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 272620002630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620002631 Walker A/P-loop; other site 272620002632 ATP binding site [chemical binding]; other site 272620002633 Q-loop/lid; other site 272620002634 ABC transporter signature motif; other site 272620002635 Walker B; other site 272620002636 D-loop; other site 272620002637 H-loop/switch region; other site 272620002638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620002639 Walker A/P-loop; other site 272620002640 ATP binding site [chemical binding]; other site 272620002641 Q-loop/lid; other site 272620002642 ABC transporter signature motif; other site 272620002643 Walker B; other site 272620002644 D-loop; other site 272620002645 H-loop/switch region; other site 272620002646 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 272620002647 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 272620002648 molybdenum-pterin binding domain; Region: Mop; TIGR00638 272620002649 TOBE domain; Region: TOBE; pfam03459 272620002650 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 272620002651 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 272620002652 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620002653 substrate binding pocket [chemical binding]; other site 272620002654 membrane-bound complex binding site; other site 272620002655 hinge residues; other site 272620002656 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272620002657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620002658 dimer interface [polypeptide binding]; other site 272620002659 conserved gate region; other site 272620002660 putative PBP binding loops; other site 272620002661 ABC-ATPase subunit interface; other site 272620002662 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 272620002663 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620002664 Walker A/P-loop; other site 272620002665 ATP binding site [chemical binding]; other site 272620002666 Q-loop/lid; other site 272620002667 ABC transporter signature motif; other site 272620002668 Walker B; other site 272620002669 D-loop; other site 272620002670 H-loop/switch region; other site 272620002671 TOBE domain; Region: TOBE; cl01440 272620002672 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 272620002673 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002674 active site 272620002675 motif I; other site 272620002676 motif II; other site 272620002677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002678 6-phosphogluconolactonase; Provisional; Region: PRK11028 272620002679 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 272620002680 Sensors of blue-light using FAD; Region: BLUF; smart01034 272620002681 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620002682 transcriptional regulator MirA; Provisional; Region: PRK15043 272620002683 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 272620002684 DNA binding residues [nucleotide binding] 272620002685 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620002686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620002687 DNA binding residues [nucleotide binding] 272620002688 dimerization interface [polypeptide binding]; other site 272620002689 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272620002690 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272620002691 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620002692 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620002693 Ligand Binding Site [chemical binding]; other site 272620002694 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272620002695 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272620002696 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620002697 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272620002698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002699 motif I; other site 272620002700 motif II; other site 272620002701 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272620002702 acyl-CoA thioesterase; Provisional; Region: PRK10531 272620002703 putative pectinesterase; Region: PLN02432; cl01911 272620002704 imidazolonepropionase; Validated; Region: PRK09356 272620002705 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 272620002706 active site 272620002707 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 272620002708 putative active site [active] 272620002709 putative metal binding site [ion binding]; other site 272620002710 histidine utilization repressor; Provisional; Region: PRK14999 272620002711 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620002712 DNA-binding site [nucleotide binding]; DNA binding site 272620002713 UTRA domain; Region: UTRA; pfam07702 272620002714 urocanate hydratase; Provisional; Region: PRK05414 272620002715 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 272620002716 active sites [active] 272620002717 tetramer interface [polypeptide binding]; other site 272620002718 putative proline-specific permease; Provisional; Region: proY; PRK10580 272620002719 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272620002720 substrate binding site [chemical binding]; other site 272620002721 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 272620002722 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620002723 inhibitor-cofactor binding pocket; inhibition site 272620002724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620002725 catalytic residue [active] 272620002726 biotin synthase; Provisional; Region: PRK15108 272620002727 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620002728 FeS/SAM binding site; other site 272620002729 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 272620002730 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 272620002731 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272620002732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620002733 catalytic residue [active] 272620002734 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272620002735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620002736 S-adenosylmethionine binding site [chemical binding]; other site 272620002737 AAA domain; Region: AAA_26; pfam13500 272620002738 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 272620002739 excinuclease ABC subunit B; Provisional; Region: PRK05298 272620002740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620002741 ATP binding site [chemical binding]; other site 272620002742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620002743 nucleotide binding region [chemical binding]; other site 272620002744 ATP-binding site [chemical binding]; other site 272620002745 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272620002746 UvrB/uvrC motif; Region: UVR; pfam02151 272620002747 sensor protein BasS/PmrB; Provisional; Region: PRK10755 272620002748 HAMP domain; Region: HAMP; pfam00672 272620002749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620002750 ATP binding site [chemical binding]; other site 272620002751 Mg2+ binding site [ion binding]; other site 272620002752 G-X-G motif; other site 272620002753 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 272620002754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620002755 active site 272620002756 phosphorylation site [posttranslational modification] 272620002757 intermolecular recognition site; other site 272620002758 dimerization interface [polypeptide binding]; other site 272620002759 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620002760 DNA binding site [nucleotide binding] 272620002761 putative metal dependent hydrolase; Provisional; Region: PRK11598 272620002762 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 272620002763 Sulfatase; Region: Sulfatase; pfam00884 272620002764 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 272620002765 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 272620002766 phosphate binding site [ion binding]; other site 272620002767 putative substrate binding pocket [chemical binding]; other site 272620002768 dimer interface [polypeptide binding]; other site 272620002769 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 272620002770 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620002771 FeS/SAM binding site; other site 272620002772 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 272620002773 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 272620002774 MPT binding site; other site 272620002775 trimer interface [polypeptide binding]; other site 272620002776 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 272620002777 trimer interface [polypeptide binding]; other site 272620002778 dimer interface [polypeptide binding]; other site 272620002779 putative active site [active] 272620002780 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 272620002781 MoaE interaction surface [polypeptide binding]; other site 272620002782 MoeB interaction surface [polypeptide binding]; other site 272620002783 thiocarboxylated glycine; other site 272620002784 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 272620002785 MoaE homodimer interface [polypeptide binding]; other site 272620002786 MoaD interaction [polypeptide binding]; other site 272620002787 active site residues [active] 272620002788 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272620002789 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 272620002790 Predicted integral membrane protein [Function unknown]; Region: COG0392 272620002791 cardiolipin synthase 2; Provisional; Region: PRK11263 272620002792 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272620002793 putative active site [active] 272620002794 catalytic site [active] 272620002795 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 272620002796 putative active site [active] 272620002797 catalytic site [active] 272620002798 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 272620002799 putative catalytic site [active] 272620002800 putative metal binding site [ion binding]; other site 272620002801 putative phosphate binding site [ion binding]; other site 272620002802 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 272620002803 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272620002804 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272620002805 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272620002806 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272620002807 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272620002808 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272620002809 Walker A/P-loop; other site 272620002810 ATP binding site [chemical binding]; other site 272620002811 Q-loop/lid; other site 272620002812 ABC transporter signature motif; other site 272620002813 Walker B; other site 272620002814 D-loop; other site 272620002815 H-loop/switch region; other site 272620002816 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272620002817 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272620002818 Walker A/P-loop; other site 272620002819 ATP binding site [chemical binding]; other site 272620002820 Q-loop/lid; other site 272620002821 ABC transporter signature motif; other site 272620002822 Walker B; other site 272620002823 D-loop; other site 272620002824 H-loop/switch region; other site 272620002825 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 272620002826 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620002827 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620002828 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 272620002829 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620002830 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 272620002831 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272620002832 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620002833 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620002834 dimerization interface [polypeptide binding]; other site 272620002835 substrate binding pocket [chemical binding]; other site 272620002836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002837 D-galactonate transporter; Region: 2A0114; TIGR00893 272620002838 putative substrate translocation pore; other site 272620002839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002840 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272620002841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620002842 NAD(P) binding site [chemical binding]; other site 272620002843 active site 272620002844 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272620002845 TPP-binding site [chemical binding]; other site 272620002846 dimer interface [polypeptide binding]; other site 272620002847 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 272620002848 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272620002849 PYR/PP interface [polypeptide binding]; other site 272620002850 dimer interface [polypeptide binding]; other site 272620002851 TPP binding site [chemical binding]; other site 272620002852 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272620002853 helicase 45; Provisional; Region: PTZ00424 272620002854 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272620002855 ATP binding site [chemical binding]; other site 272620002856 Mg++ binding site [ion binding]; other site 272620002857 motif III; other site 272620002858 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620002859 nucleotide binding region [chemical binding]; other site 272620002860 ATP-binding site [chemical binding]; other site 272620002861 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 272620002862 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272620002863 DEAD_2; Region: DEAD_2; pfam06733 272620002864 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272620002865 glycosyl transferase family protein; Provisional; Region: PRK08136 272620002866 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272620002867 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 272620002868 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 272620002869 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272620002870 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 272620002871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620002872 S-adenosylmethionine binding site [chemical binding]; other site 272620002873 putative mechanosensitive channel protein; Provisional; Region: PRK11465 272620002874 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620002875 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 272620002876 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620002877 Walker A/P-loop; other site 272620002878 ATP binding site [chemical binding]; other site 272620002879 Q-loop/lid; other site 272620002880 ABC transporter signature motif; other site 272620002881 Walker B; other site 272620002882 D-loop; other site 272620002883 H-loop/switch region; other site 272620002884 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620002885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620002886 dimer interface [polypeptide binding]; other site 272620002887 conserved gate region; other site 272620002888 putative PBP binding loops; other site 272620002889 ABC-ATPase subunit interface; other site 272620002890 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 272620002891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620002892 substrate binding pocket [chemical binding]; other site 272620002893 membrane-bound complex binding site; other site 272620002894 hinge residues; other site 272620002895 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 272620002896 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 272620002897 dimerization interface [polypeptide binding]; other site 272620002898 DPS ferroxidase diiron center [ion binding]; other site 272620002899 ion pore; other site 272620002900 threonine and homoserine efflux system; Provisional; Region: PRK10532 272620002901 EamA-like transporter family; Region: EamA; pfam00892 272620002902 outer membrane protein X; Provisional; Region: ompX; PRK09408 272620002903 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 272620002904 Sulfatase; Region: Sulfatase; pfam00884 272620002905 manganese transport regulator MntR; Provisional; Region: PRK11050 272620002906 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272620002907 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 272620002908 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272620002909 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 272620002910 transmembrane helices; other site 272620002911 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272620002912 beta-galactosidase; Region: BGL; TIGR03356 272620002913 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272620002914 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620002915 DNA-binding site [nucleotide binding]; DNA binding site 272620002916 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272620002917 L,D-transpeptidase; Provisional; Region: PRK10260 272620002918 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272620002919 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 272620002920 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 272620002921 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 272620002922 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620002923 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620002924 Walker A/P-loop; other site 272620002925 ATP binding site [chemical binding]; other site 272620002926 Q-loop/lid; other site 272620002927 ABC transporter signature motif; other site 272620002928 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620002929 Walker B; other site 272620002930 D-loop; other site 272620002931 ABC transporter; Region: ABC_tran_2; pfam12848 272620002932 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620002933 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 272620002934 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272620002935 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 272620002936 putative active site [active] 272620002937 putative catalytic site [active] 272620002938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620002939 D-galactonate transporter; Region: 2A0114; TIGR00893 272620002940 putative substrate translocation pore; other site 272620002941 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620002942 DNA binding site [nucleotide binding] 272620002943 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620002944 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272620002945 ligand binding site [chemical binding]; other site 272620002946 dimerization interface [polypeptide binding]; other site 272620002947 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 272620002948 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272620002949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002950 active site 272620002951 motif I; other site 272620002952 motif II; other site 272620002953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620002954 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 272620002955 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 272620002956 dimer interface [polypeptide binding]; other site 272620002957 active site 272620002958 glycine loop; other site 272620002959 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 272620002960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620002961 FeS/SAM binding site; other site 272620002962 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 272620002963 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272620002964 ATP binding site [chemical binding]; other site 272620002965 substrate interface [chemical binding]; other site 272620002966 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 272620002967 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 272620002968 dimer interface [polypeptide binding]; other site 272620002969 putative functional site; other site 272620002970 putative MPT binding site; other site 272620002971 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 272620002972 catalytic nucleophile [active] 272620002973 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 272620002974 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620002975 Walker A/P-loop; other site 272620002976 ATP binding site [chemical binding]; other site 272620002977 Q-loop/lid; other site 272620002978 ABC transporter signature motif; other site 272620002979 Walker B; other site 272620002980 D-loop; other site 272620002981 H-loop/switch region; other site 272620002982 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620002983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620002984 Walker A/P-loop; other site 272620002985 ATP binding site [chemical binding]; other site 272620002986 Q-loop/lid; other site 272620002987 ABC transporter signature motif; other site 272620002988 Walker B; other site 272620002989 D-loop; other site 272620002990 H-loop/switch region; other site 272620002991 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272620002992 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 272620002993 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 272620002994 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 272620002995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620002996 dimer interface [polypeptide binding]; other site 272620002997 conserved gate region; other site 272620002998 putative PBP binding loops; other site 272620002999 ABC-ATPase subunit interface; other site 272620003000 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 272620003001 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620003002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003003 dimer interface [polypeptide binding]; other site 272620003004 conserved gate region; other site 272620003005 putative PBP binding loops; other site 272620003006 ABC-ATPase subunit interface; other site 272620003007 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 272620003008 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272620003009 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620003010 FeS/SAM binding site; other site 272620003011 galactoside permease; Reviewed; Region: lacY; PRK09528 272620003012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003013 putative substrate translocation pore; other site 272620003014 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 272620003015 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 272620003016 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 272620003017 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272620003018 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 272620003019 putative C-terminal domain interface [polypeptide binding]; other site 272620003020 putative GSH binding site (G-site) [chemical binding]; other site 272620003021 putative dimer interface [polypeptide binding]; other site 272620003022 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 272620003023 putative N-terminal domain interface [polypeptide binding]; other site 272620003024 putative dimer interface [polypeptide binding]; other site 272620003025 putative substrate binding pocket (H-site) [chemical binding]; other site 272620003026 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 272620003027 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272620003028 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272620003029 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 272620003030 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272620003031 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620003032 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 272620003033 active site 272620003034 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 272620003035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003036 putative substrate translocation pore; other site 272620003037 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272620003038 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620003039 active site 272620003040 motif I; other site 272620003041 motif II; other site 272620003042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620003043 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272620003044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003045 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620003046 putative substrate translocation pore; other site 272620003047 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 272620003048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620003049 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272620003050 putative transporter; Provisional; Region: PRK04972 272620003051 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 272620003052 TrkA-C domain; Region: TrkA_C; pfam02080 272620003053 TrkA-C domain; Region: TrkA_C; pfam02080 272620003054 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 272620003055 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 272620003056 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 272620003057 GSH binding site [chemical binding]; other site 272620003058 catalytic residues [active] 272620003059 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 272620003060 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272620003061 dimer interface [polypeptide binding]; other site 272620003062 FMN binding site [chemical binding]; other site 272620003063 NADPH bind site [chemical binding]; other site 272620003064 RimK-like ATP-grasp domain; Region: RimK; pfam08443 272620003065 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 272620003066 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 272620003067 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272620003068 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 272620003069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620003070 Walker A/P-loop; other site 272620003071 ATP binding site [chemical binding]; other site 272620003072 Q-loop/lid; other site 272620003073 ABC transporter signature motif; other site 272620003074 Walker B; other site 272620003075 D-loop; other site 272620003076 H-loop/switch region; other site 272620003077 TOBE domain; Region: TOBE_2; pfam08402 272620003078 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272620003079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003080 dimer interface [polypeptide binding]; other site 272620003081 conserved gate region; other site 272620003082 putative PBP binding loops; other site 272620003083 ABC-ATPase subunit interface; other site 272620003084 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272620003085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003086 dimer interface [polypeptide binding]; other site 272620003087 conserved gate region; other site 272620003088 putative PBP binding loops; other site 272620003089 ABC-ATPase subunit interface; other site 272620003090 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 272620003091 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 272620003092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620003093 S-adenosylmethionine binding site [chemical binding]; other site 272620003094 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272620003095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620003096 active site 272620003097 phosphorylation site [posttranslational modification] 272620003098 intermolecular recognition site; other site 272620003099 dimerization interface [polypeptide binding]; other site 272620003100 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620003101 DNA binding site [nucleotide binding] 272620003102 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 272620003103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620003104 dimer interface [polypeptide binding]; other site 272620003105 phosphorylation site [posttranslational modification] 272620003106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620003107 ATP binding site [chemical binding]; other site 272620003108 Mg2+ binding site [ion binding]; other site 272620003109 G-X-G motif; other site 272620003110 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 272620003111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620003112 substrate binding pocket [chemical binding]; other site 272620003113 membrane-bound complex binding site; other site 272620003114 hinge residues; other site 272620003115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003116 dimer interface [polypeptide binding]; other site 272620003117 conserved gate region; other site 272620003118 putative PBP binding loops; other site 272620003119 ABC-ATPase subunit interface; other site 272620003120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620003121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003122 dimer interface [polypeptide binding]; other site 272620003123 conserved gate region; other site 272620003124 putative PBP binding loops; other site 272620003125 ABC-ATPase subunit interface; other site 272620003126 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 272620003127 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620003128 substrate binding pocket [chemical binding]; other site 272620003129 membrane-bound complex binding site; other site 272620003130 hinge residues; other site 272620003131 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 272620003132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620003133 Walker A/P-loop; other site 272620003134 ATP binding site [chemical binding]; other site 272620003135 Q-loop/lid; other site 272620003136 ABC transporter signature motif; other site 272620003137 Walker B; other site 272620003138 D-loop; other site 272620003139 H-loop/switch region; other site 272620003140 putative lipoprotein; Provisional; Region: PRK10533 272620003141 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620003142 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620003143 metal binding site [ion binding]; metal-binding site 272620003144 active site 272620003145 I-site; other site 272620003146 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 272620003147 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 272620003148 amidase catalytic site [active] 272620003149 Zn binding residues [ion binding]; other site 272620003150 substrate binding site [chemical binding]; other site 272620003151 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272620003152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620003153 NAD(P) binding site [chemical binding]; other site 272620003154 active site 272620003155 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 272620003156 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272620003157 putative NAD(P) binding site [chemical binding]; other site 272620003158 putative active site [active] 272620003159 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 272620003160 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 272620003161 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 272620003162 tetramer interface [polypeptide binding]; other site 272620003163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620003164 catalytic residue [active] 272620003165 pyruvate dehydrogenase; Provisional; Region: PRK09124 272620003166 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 272620003167 PYR/PP interface [polypeptide binding]; other site 272620003168 dimer interface [polypeptide binding]; other site 272620003169 tetramer interface [polypeptide binding]; other site 272620003170 TPP binding site [chemical binding]; other site 272620003171 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620003172 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 272620003173 TPP-binding site [chemical binding]; other site 272620003174 DoxX; Region: DoxX; pfam07681 272620003175 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 272620003176 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 272620003177 FAD binding pocket [chemical binding]; other site 272620003178 FAD binding motif [chemical binding]; other site 272620003179 phosphate binding motif [ion binding]; other site 272620003180 beta-alpha-beta structure motif; other site 272620003181 NAD binding pocket [chemical binding]; other site 272620003182 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620003183 catalytic loop [active] 272620003184 iron binding site [ion binding]; other site 272620003185 hybrid cluster protein; Provisional; Region: PRK05290 272620003186 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272620003187 ACS interaction site; other site 272620003188 CODH interaction site; other site 272620003189 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 272620003190 hybrid metal cluster; other site 272620003191 Predicted membrane protein [Function unknown]; Region: COG2431 272620003192 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272620003193 amphipathic channel; other site 272620003194 Asn-Pro-Ala signature motifs; other site 272620003195 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 272620003196 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 272620003197 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 272620003198 putative active site [active] 272620003199 putative metal-binding site [ion binding]; other site 272620003200 macrolide transporter subunit MacA; Provisional; Region: PRK11578 272620003201 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620003202 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620003203 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 272620003204 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272620003205 Walker A/P-loop; other site 272620003206 ATP binding site [chemical binding]; other site 272620003207 Q-loop/lid; other site 272620003208 ABC transporter signature motif; other site 272620003209 Walker B; other site 272620003210 D-loop; other site 272620003211 H-loop/switch region; other site 272620003212 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272620003213 FtsX-like permease family; Region: FtsX; pfam02687 272620003214 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272620003215 DNA-binding site [nucleotide binding]; DNA binding site 272620003216 RNA-binding motif; other site 272620003217 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 272620003218 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 272620003219 Clp amino terminal domain; Region: Clp_N; pfam02861 272620003220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620003221 Walker A motif; other site 272620003222 ATP binding site [chemical binding]; other site 272620003223 Walker B motif; other site 272620003224 arginine finger; other site 272620003225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620003226 Walker A motif; other site 272620003227 ATP binding site [chemical binding]; other site 272620003228 Walker B motif; other site 272620003229 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272620003230 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272620003231 rRNA binding site [nucleotide binding]; other site 272620003232 predicted 30S ribosome binding site; other site 272620003233 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 272620003234 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 272620003235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620003236 Walker A/P-loop; other site 272620003237 ATP binding site [chemical binding]; other site 272620003238 Q-loop/lid; other site 272620003239 ABC transporter signature motif; other site 272620003240 Walker B; other site 272620003241 D-loop; other site 272620003242 H-loop/switch region; other site 272620003243 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 272620003244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272620003245 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620003246 Walker A/P-loop; other site 272620003247 ATP binding site [chemical binding]; other site 272620003248 Q-loop/lid; other site 272620003249 ABC transporter signature motif; other site 272620003250 Walker B; other site 272620003251 D-loop; other site 272620003252 H-loop/switch region; other site 272620003253 thioredoxin reductase; Provisional; Region: PRK10262 272620003254 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620003255 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620003256 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 272620003257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620003258 putative DNA binding site [nucleotide binding]; other site 272620003259 putative Zn2+ binding site [ion binding]; other site 272620003260 AsnC family; Region: AsnC_trans_reg; pfam01037 272620003261 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 272620003262 DNA translocase FtsK; Provisional; Region: PRK10263 272620003263 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 272620003264 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 272620003265 periplasmic chaperone LolA; Region: lolA; TIGR00547 272620003266 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 272620003267 recombination factor protein RarA; Reviewed; Region: PRK13342 272620003268 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620003269 Walker A motif; other site 272620003270 ATP binding site [chemical binding]; other site 272620003271 Walker B motif; other site 272620003272 arginine finger; other site 272620003273 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272620003274 seryl-tRNA synthetase; Provisional; Region: PRK05431 272620003275 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272620003276 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272620003277 dimer interface [polypeptide binding]; other site 272620003278 active site 272620003279 motif 1; other site 272620003280 motif 2; other site 272620003281 motif 3; other site 272620003282 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 272620003283 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 272620003284 putative [Fe4-S4] binding site [ion binding]; other site 272620003285 putative molybdopterin cofactor binding site [chemical binding]; other site 272620003286 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 272620003287 putative molybdopterin cofactor binding site; other site 272620003288 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 272620003289 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 272620003290 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 272620003291 putative MFS family transporter protein; Provisional; Region: PRK03633 272620003292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003293 putative substrate translocation pore; other site 272620003294 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 272620003295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620003296 FeS/SAM binding site; other site 272620003297 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272620003298 Pyruvate formate lyase 1; Region: PFL1; cd01678 272620003299 coenzyme A binding site [chemical binding]; other site 272620003300 active site 272620003301 catalytic residues [active] 272620003302 glycine loop; other site 272620003303 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 272620003304 uncharacterized domain; Region: TIGR00702 272620003305 YcaO-like family; Region: YcaO; pfam02624 272620003306 Predicted membrane protein [Function unknown]; Region: COG2323 272620003307 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 272620003308 homodimer interface [polypeptide binding]; other site 272620003309 substrate-cofactor binding pocket; other site 272620003310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620003311 catalytic residue [active] 272620003312 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 272620003313 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 272620003314 hinge; other site 272620003315 active site 272620003316 cytidylate kinase; Provisional; Region: cmk; PRK00023 272620003317 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272620003318 CMP-binding site; other site 272620003319 The sites determining sugar specificity; other site 272620003320 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 272620003321 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 272620003322 RNA binding site [nucleotide binding]; other site 272620003323 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 272620003324 RNA binding site [nucleotide binding]; other site 272620003325 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 272620003326 RNA binding site [nucleotide binding]; other site 272620003327 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 272620003328 RNA binding site [nucleotide binding]; other site 272620003329 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 272620003330 RNA binding site [nucleotide binding]; other site 272620003331 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272620003332 IHF dimer interface [polypeptide binding]; other site 272620003333 IHF - DNA interface [nucleotide binding]; other site 272620003334 ComEC family competence protein; Provisional; Region: PRK11539 272620003335 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 272620003336 Competence protein; Region: Competence; pfam03772 272620003337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272620003338 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 272620003339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272620003340 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 272620003341 Walker A/P-loop; other site 272620003342 ATP binding site [chemical binding]; other site 272620003343 Q-loop/lid; other site 272620003344 ABC transporter signature motif; other site 272620003345 Walker B; other site 272620003346 D-loop; other site 272620003347 H-loop/switch region; other site 272620003348 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 272620003349 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 272620003350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 272620003351 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 272620003352 Trm112p-like protein; Region: Trm112p; cl01066 272620003353 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 272620003354 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 272620003355 Ligand binding site; other site 272620003356 oligomer interface; other site 272620003357 hypothetical protein; Provisional; Region: PRK10593 272620003358 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272620003359 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272620003360 putative active site [active] 272620003361 Methyltransferase domain; Region: Methyltransf_31; pfam13847 272620003362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620003363 S-adenosylmethionine binding site [chemical binding]; other site 272620003364 condesin subunit F; Provisional; Region: PRK05260 272620003365 condesin subunit E; Provisional; Region: PRK05256 272620003366 cell division protein MukB; Provisional; Region: mukB; PRK04863 272620003367 P-loop containing region of AAA domain; Region: AAA_29; cl17516 272620003368 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 272620003369 murein L,D-transpeptidase; Provisional; Region: PRK10594 272620003370 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 272620003371 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272620003372 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272620003373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 272620003374 Peptidase M15; Region: Peptidase_M15_3; cl01194 272620003375 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272620003376 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 272620003377 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620003378 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620003379 homodimer interface [polypeptide binding]; other site 272620003380 catalytic residue [active] 272620003381 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 272620003382 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 272620003383 eyelet of channel; other site 272620003384 trimer interface [polypeptide binding]; other site 272620003385 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272620003386 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272620003387 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272620003388 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 272620003389 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272620003390 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272620003391 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272620003392 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272620003393 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272620003394 putative dimer interface [polypeptide binding]; other site 272620003395 putative anticodon binding site; other site 272620003396 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272620003397 homodimer interface [polypeptide binding]; other site 272620003398 motif 1; other site 272620003399 motif 2; other site 272620003400 active site 272620003401 motif 3; other site 272620003402 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272620003403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620003404 dimerization interface [polypeptide binding]; other site 272620003405 putative DNA binding site [nucleotide binding]; other site 272620003406 putative Zn2+ binding site [ion binding]; other site 272620003407 AsnC family; Region: AsnC_trans_reg; pfam01037 272620003408 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 272620003409 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 272620003410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620003411 catalytic residue [active] 272620003412 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272620003413 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 272620003414 allantoate amidohydrolase; Reviewed; Region: PRK12893 272620003415 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272620003416 active site 272620003417 metal binding site [ion binding]; metal-binding site 272620003418 dimer interface [polypeptide binding]; other site 272620003419 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272620003420 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272620003421 metal binding site [ion binding]; metal-binding site 272620003422 putative dimer interface [polypeptide binding]; other site 272620003423 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 272620003424 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 272620003425 active site 272620003426 aminopeptidase N; Provisional; Region: pepN; PRK14015 272620003427 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 272620003428 active site 272620003429 Zn binding site [ion binding]; other site 272620003430 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 272620003431 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272620003432 Walker A/P-loop; other site 272620003433 ATP binding site [chemical binding]; other site 272620003434 Q-loop/lid; other site 272620003435 ABC transporter signature motif; other site 272620003436 Walker B; other site 272620003437 D-loop; other site 272620003438 H-loop/switch region; other site 272620003439 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272620003440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003441 dimer interface [polypeptide binding]; other site 272620003442 conserved gate region; other site 272620003443 putative PBP binding loops; other site 272620003444 ABC-ATPase subunit interface; other site 272620003445 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 272620003446 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272620003447 active site 272620003448 dimer interface [polypeptide binding]; other site 272620003449 non-prolyl cis peptide bond; other site 272620003450 insertion regions; other site 272620003451 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272620003452 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620003453 substrate binding pocket [chemical binding]; other site 272620003454 membrane-bound complex binding site; other site 272620003455 hinge residues; other site 272620003456 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 272620003457 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272620003458 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 272620003459 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 272620003460 quinone interaction residues [chemical binding]; other site 272620003461 active site 272620003462 catalytic residues [active] 272620003463 FMN binding site [chemical binding]; other site 272620003464 substrate binding site [chemical binding]; other site 272620003465 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 272620003466 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 272620003467 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 272620003468 MOSC domain; Region: MOSC; pfam03473 272620003469 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272620003470 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620003471 catalytic loop [active] 272620003472 iron binding site [ion binding]; other site 272620003473 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 272620003474 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 272620003475 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272620003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620003477 S-adenosylmethionine binding site [chemical binding]; other site 272620003478 ABC transporter ATPase component; Reviewed; Region: PRK11147 272620003479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620003480 Walker A/P-loop; other site 272620003481 ATP binding site [chemical binding]; other site 272620003482 Q-loop/lid; other site 272620003483 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620003484 ABC transporter; Region: ABC_tran_2; pfam12848 272620003485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620003486 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 272620003487 Paraquat-inducible protein A; Region: PqiA; pfam04403 272620003488 Paraquat-inducible protein A; Region: PqiA; pfam04403 272620003489 paraquat-inducible protein B; Provisional; Region: PRK10807 272620003490 mce related protein; Region: MCE; pfam02470 272620003491 mce related protein; Region: MCE; pfam02470 272620003492 mce related protein; Region: MCE; pfam02470 272620003493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 272620003494 Protein of unknown function (DUF330); Region: DUF330; pfam03886 272620003495 ribosome modulation factor; Provisional; Region: PRK14563 272620003496 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 272620003497 active site 1 [active] 272620003498 dimer interface [polypeptide binding]; other site 272620003499 active site 2 [active] 272620003500 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 272620003501 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272620003502 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 272620003503 outer membrane protein A; Reviewed; Region: PRK10808 272620003504 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 272620003505 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620003506 ligand binding site [chemical binding]; other site 272620003507 SOS cell division inhibitor; Provisional; Region: PRK10595 272620003508 TfoX N-terminal domain; Region: TfoX_N; pfam04993 272620003509 TfoX C-terminal domain; Region: TfoX_C; pfam04994 272620003510 TIGR01666 family membrane protein; Region: YCCS 272620003511 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 272620003512 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272620003513 Predicted membrane protein [Function unknown]; Region: COG3304 272620003514 Domain of unknown function (DUF307); Region: DUF307; pfam03733 272620003515 Domain of unknown function (DUF307); Region: DUF307; pfam03733 272620003516 DNA helicase IV; Provisional; Region: helD; PRK11054 272620003517 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 272620003518 Part of AAA domain; Region: AAA_19; pfam13245 272620003519 Family description; Region: UvrD_C_2; pfam13538 272620003520 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 272620003521 active site 272620003522 dimer interfaces [polypeptide binding]; other site 272620003523 catalytic residues [active] 272620003524 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 272620003525 type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661 272620003526 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 272620003527 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 272620003528 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272620003529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620003530 Walker A/P-loop; other site 272620003531 ATP binding site [chemical binding]; other site 272620003532 Q-loop/lid; other site 272620003533 ABC transporter signature motif; other site 272620003534 Walker B; other site 272620003535 D-loop; other site 272620003536 H-loop/switch region; other site 272620003537 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272620003538 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620003539 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620003540 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 272620003541 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272620003542 heat shock protein HspQ; Provisional; Region: PRK14129 272620003543 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 272620003544 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 272620003545 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 272620003546 putative RNA binding site [nucleotide binding]; other site 272620003547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620003548 S-adenosylmethionine binding site [chemical binding]; other site 272620003549 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 272620003550 substrate binding site [chemical binding]; other site 272620003551 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620003552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620003553 acylphosphatase; Provisional; Region: PRK14426 272620003554 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 272620003555 sulfur transfer protein TusE; Provisional; Region: PRK11508 272620003556 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 272620003557 YccA-like proteins; Region: YccA_like; cd10433 272620003558 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 272620003559 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272620003560 peptide binding site [polypeptide binding]; other site 272620003561 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620003562 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620003563 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272620003564 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 272620003565 FMN-binding pocket [chemical binding]; other site 272620003566 flavin binding motif; other site 272620003567 phosphate binding motif [ion binding]; other site 272620003568 beta-alpha-beta structure motif; other site 272620003569 NAD binding pocket [chemical binding]; other site 272620003570 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620003571 catalytic loop [active] 272620003572 iron binding site [ion binding]; other site 272620003573 succinic semialdehyde dehydrogenase; Region: PLN02278 272620003574 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 272620003575 tetramerization interface [polypeptide binding]; other site 272620003576 NAD(P) binding site [chemical binding]; other site 272620003577 catalytic residues [active] 272620003578 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272620003579 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272620003580 [2Fe-2S] cluster binding site [ion binding]; other site 272620003581 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 272620003582 putative alpha subunit interface [polypeptide binding]; other site 272620003583 putative active site [active] 272620003584 putative substrate binding site [chemical binding]; other site 272620003585 Fe binding site [ion binding]; other site 272620003586 BCCT family transporter; Region: BCCT; cl00569 272620003587 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 272620003588 tartrate dehydrogenase; Region: TTC; TIGR02089 272620003589 transcriptional activator TtdR; Provisional; Region: PRK09801 272620003590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620003591 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 272620003592 putative effector binding pocket; other site 272620003593 putative dimerization interface [polypeptide binding]; other site 272620003594 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 272620003595 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 272620003596 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 272620003597 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 272620003598 NAD(P) binding site [chemical binding]; other site 272620003599 catalytic residues [active] 272620003600 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 272620003601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620003602 non-specific DNA binding site [nucleotide binding]; other site 272620003603 salt bridge; other site 272620003604 sequence-specific DNA binding site [nucleotide binding]; other site 272620003605 Cupin domain; Region: Cupin_2; pfam07883 272620003606 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 272620003607 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 272620003608 catalytic triad [active] 272620003609 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 272620003610 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272620003611 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272620003612 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272620003613 classical (c) SDRs; Region: SDR_c; cd05233 272620003614 NAD(P) binding site [chemical binding]; other site 272620003615 active site 272620003616 Predicted transcriptional regulators [Transcription]; Region: COG1733 272620003617 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272620003618 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 272620003619 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 272620003620 catalytic core [active] 272620003621 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 272620003622 hypothetical protein; Provisional; Region: PRK10174 272620003623 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 272620003624 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272620003625 General stress protein [General function prediction only]; Region: GsiB; COG3729 272620003626 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272620003627 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 272620003628 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 272620003629 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 272620003630 putative FMN binding site [chemical binding]; other site 272620003631 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272620003632 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272620003633 homotrimer interaction site [polypeptide binding]; other site 272620003634 putative active site [active] 272620003635 Isochorismatase family; Region: Isochorismatase; pfam00857 272620003636 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272620003637 catalytic triad [active] 272620003638 conserved cis-peptide bond; other site 272620003639 pyrimidine utilization protein A; Region: RutA; TIGR03612 272620003640 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272620003641 active site 272620003642 dimer interface [polypeptide binding]; other site 272620003643 non-prolyl cis peptide bond; other site 272620003644 insertion regions; other site 272620003645 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272620003646 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 272620003647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620003648 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 272620003649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 272620003650 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 272620003651 Predicted transcriptional regulator [Transcription]; Region: COG3905 272620003652 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 272620003653 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 272620003654 Glutamate binding site [chemical binding]; other site 272620003655 NAD binding site [chemical binding]; other site 272620003656 catalytic residues [active] 272620003657 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 272620003658 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 272620003659 Na binding site [ion binding]; other site 272620003660 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 272620003661 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 272620003662 Nucleoside recognition; Region: Gate; pfam07670 272620003663 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 272620003664 FTR1 family protein; Region: TIGR00145 272620003665 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 272620003666 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 272620003667 Imelysin; Region: Peptidase_M75; pfam09375 272620003668 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 272620003669 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 272620003670 hypothetical protein; Provisional; Region: PRK10536 272620003671 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 272620003672 Isochorismatase family; Region: Isochorismatase; pfam00857 272620003673 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 272620003674 catalytic triad [active] 272620003675 dimer interface [polypeptide binding]; other site 272620003676 conserved cis-peptide bond; other site 272620003677 Pirin-related protein [General function prediction only]; Region: COG1741 272620003678 Pirin; Region: Pirin; pfam02678 272620003679 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 272620003680 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 272620003681 putative effector binding pocket; other site 272620003682 putative dimerization interface [polypeptide binding]; other site 272620003683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620003684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620003685 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 272620003686 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 272620003687 active site 272620003688 Mn binding site [ion binding]; other site 272620003689 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 272620003690 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 272620003691 putative ligand binding site [chemical binding]; other site 272620003692 NAD binding site [chemical binding]; other site 272620003693 dimerization interface [polypeptide binding]; other site 272620003694 catalytic site [active] 272620003695 putative hydrolase; Validated; Region: PRK09248 272620003696 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 272620003697 active site 272620003698 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 272620003699 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 272620003700 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 272620003701 putative ADP-ribose binding site [chemical binding]; other site 272620003702 putative active site [active] 272620003703 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 272620003704 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620003705 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 272620003706 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272620003707 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 272620003708 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 272620003709 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272620003710 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 272620003711 Ligand binding site; other site 272620003712 DXD motif; other site 272620003713 lipoprotein; Provisional; Region: PRK10175 272620003714 secY/secA suppressor protein; Provisional; Region: PRK11467 272620003715 drug efflux system protein MdtG; Provisional; Region: PRK09874 272620003716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003717 putative substrate translocation pore; other site 272620003718 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 272620003719 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272620003720 putative acyl-acceptor binding pocket; other site 272620003721 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 272620003722 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 272620003723 active site residue [active] 272620003724 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 272620003725 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272620003726 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 272620003727 DNA damage-inducible protein I; Provisional; Region: PRK10597 272620003728 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 272620003729 active site 272620003730 substrate binding pocket [chemical binding]; other site 272620003731 dimer interface [polypeptide binding]; other site 272620003732 lipoprotein; Provisional; Region: PRK10598 272620003733 multidrug resistance protein MdtH; Provisional; Region: PRK11646 272620003734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003735 putative substrate translocation pore; other site 272620003736 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 272620003737 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272620003738 hypothetical protein; Provisional; Region: PRK11239 272620003739 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 272620003740 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620003741 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620003742 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 272620003743 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 272620003744 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620003745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620003746 putative substrate translocation pore; other site 272620003747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620003748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620003749 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620003750 putative effector binding pocket; other site 272620003751 dimerization interface [polypeptide binding]; other site 272620003752 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 272620003753 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272620003754 homodimer interface [polypeptide binding]; other site 272620003755 oligonucleotide binding site [chemical binding]; other site 272620003756 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 272620003757 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 272620003758 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620003759 RNA binding surface [nucleotide binding]; other site 272620003760 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272620003761 active site 272620003762 Maf-like protein; Region: Maf; pfam02545 272620003763 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272620003764 active site 272620003765 dimer interface [polypeptide binding]; other site 272620003766 hypothetical protein; Provisional; Region: PRK11193 272620003767 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 272620003768 putative phosphate acyltransferase; Provisional; Region: PRK05331 272620003769 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 272620003770 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 272620003771 dimer interface [polypeptide binding]; other site 272620003772 active site 272620003773 CoA binding pocket [chemical binding]; other site 272620003774 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 272620003775 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272620003776 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272620003777 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 272620003778 NAD(P) binding site [chemical binding]; other site 272620003779 homotetramer interface [polypeptide binding]; other site 272620003780 homodimer interface [polypeptide binding]; other site 272620003781 active site 272620003782 acyl carrier protein; Provisional; Region: acpP; PRK00982 272620003783 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 272620003784 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272620003785 dimer interface [polypeptide binding]; other site 272620003786 active site 272620003787 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272620003788 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 272620003789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620003790 catalytic residue [active] 272620003791 conserved hypothetical protein, YceG family; Region: TIGR00247 272620003792 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 272620003793 dimerization interface [polypeptide binding]; other site 272620003794 thymidylate kinase; Validated; Region: tmk; PRK00698 272620003795 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272620003796 TMP-binding site; other site 272620003797 ATP-binding site [chemical binding]; other site 272620003798 DNA polymerase III subunit delta'; Validated; Region: PRK07993 272620003799 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 272620003800 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272620003801 active site 272620003802 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 272620003803 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620003804 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620003805 active site turn [active] 272620003806 phosphorylation site [posttranslational modification] 272620003807 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 272620003808 nucleotide binding site/active site [active] 272620003809 HIT family signature motif; other site 272620003810 catalytic residue [active] 272620003811 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 272620003812 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 272620003813 putative dimer interface [polypeptide binding]; other site 272620003814 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 272620003815 thiamine kinase; Region: ycfN_thiK; TIGR02721 272620003816 thiamine kinase; Provisional; Region: thiK; PRK10271 272620003817 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 272620003818 beta-hexosaminidase; Provisional; Region: PRK05337 272620003819 hypothetical protein; Provisional; Region: PRK04940 272620003820 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 272620003821 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620003822 hypothetical protein; Provisional; Region: PRK11280 272620003823 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272620003824 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620003825 N-terminal plug; other site 272620003826 ligand-binding site [chemical binding]; other site 272620003827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620003828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620003829 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620003830 L,D-transpeptidase; Provisional; Region: PRK10190 272620003831 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620003832 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272620003833 transcription-repair coupling factor; Provisional; Region: PRK10689 272620003834 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 272620003835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620003836 ATP binding site [chemical binding]; other site 272620003837 putative Mg++ binding site [ion binding]; other site 272620003838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620003839 nucleotide binding region [chemical binding]; other site 272620003840 ATP-binding site [chemical binding]; other site 272620003841 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 272620003842 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 272620003843 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272620003844 FtsX-like permease family; Region: FtsX; pfam02687 272620003845 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 272620003846 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272620003847 Walker A/P-loop; other site 272620003848 ATP binding site [chemical binding]; other site 272620003849 Q-loop/lid; other site 272620003850 ABC transporter signature motif; other site 272620003851 Walker B; other site 272620003852 D-loop; other site 272620003853 H-loop/switch region; other site 272620003854 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 272620003855 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 272620003856 FtsX-like permease family; Region: FtsX; pfam02687 272620003857 fructokinase; Reviewed; Region: PRK09557 272620003858 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620003859 nucleotide binding site [chemical binding]; other site 272620003860 NAD-dependent deacetylase; Provisional; Region: PRK00481 272620003861 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 272620003862 NAD+ binding site [chemical binding]; other site 272620003863 substrate binding site [chemical binding]; other site 272620003864 Zn binding site [ion binding]; other site 272620003865 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272620003866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272620003867 DNA binding residues [nucleotide binding] 272620003868 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272620003869 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272620003870 substrate binding site [chemical binding]; other site 272620003871 dimer interface [polypeptide binding]; other site 272620003872 triosephosphate isomerase; Provisional; Region: PRK14565 272620003873 catalytic triad [active] 272620003874 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 272620003875 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 272620003876 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 272620003877 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272620003878 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 272620003879 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 272620003880 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 272620003881 transaldolase-like protein; Provisional; Region: PTZ00411 272620003882 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 272620003883 active site 272620003884 dimer interface [polypeptide binding]; other site 272620003885 catalytic residue [active] 272620003886 transketolase; Reviewed; Region: PRK12753 272620003887 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272620003888 TPP-binding site [chemical binding]; other site 272620003889 dimer interface [polypeptide binding]; other site 272620003890 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272620003891 PYR/PP interface [polypeptide binding]; other site 272620003892 dimer interface [polypeptide binding]; other site 272620003893 TPP binding site [chemical binding]; other site 272620003894 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272620003895 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 272620003896 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 272620003897 dimer interface [polypeptide binding]; other site 272620003898 acyl-activating enzyme (AAE) consensus motif; other site 272620003899 putative active site [active] 272620003900 AMP binding site [chemical binding]; other site 272620003901 putative CoA binding site [chemical binding]; other site 272620003902 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 272620003903 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 272620003904 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272620003905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003906 dimer interface [polypeptide binding]; other site 272620003907 conserved gate region; other site 272620003908 putative PBP binding loops; other site 272620003909 ABC-ATPase subunit interface; other site 272620003910 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272620003911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620003912 dimer interface [polypeptide binding]; other site 272620003913 conserved gate region; other site 272620003914 putative PBP binding loops; other site 272620003915 ABC-ATPase subunit interface; other site 272620003916 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 272620003917 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272620003918 Walker A/P-loop; other site 272620003919 ATP binding site [chemical binding]; other site 272620003920 Q-loop/lid; other site 272620003921 ABC transporter signature motif; other site 272620003922 Walker B; other site 272620003923 D-loop; other site 272620003924 H-loop/switch region; other site 272620003925 TOBE domain; Region: TOBE_2; pfam08402 272620003926 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 272620003927 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 272620003928 metal binding site [ion binding]; metal-binding site 272620003929 dimer interface [polypeptide binding]; other site 272620003930 Uncharacterized conserved protein [Function unknown]; Region: COG2850 272620003931 sensor protein PhoQ; Provisional; Region: PRK10815 272620003932 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 272620003933 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 272620003934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620003935 ATP binding site [chemical binding]; other site 272620003936 Mg2+ binding site [ion binding]; other site 272620003937 G-X-G motif; other site 272620003938 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 272620003939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620003940 active site 272620003941 phosphorylation site [posttranslational modification] 272620003942 intermolecular recognition site; other site 272620003943 dimerization interface [polypeptide binding]; other site 272620003944 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620003945 DNA binding site [nucleotide binding] 272620003946 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620003947 Helix-turn-helix domain; Region: HTH_18; pfam12833 272620003948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620003949 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 272620003950 adenylosuccinate lyase; Provisional; Region: PRK09285 272620003951 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 272620003952 tetramer interface [polypeptide binding]; other site 272620003953 active site 272620003954 putative lysogenization regulator; Reviewed; Region: PRK00218 272620003955 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272620003956 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 272620003957 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 272620003958 nudix motif; other site 272620003959 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 272620003960 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 272620003961 probable active site [active] 272620003962 isocitrate dehydrogenase; Validated; Region: PRK07362 272620003963 isocitrate dehydrogenase; Reviewed; Region: PRK07006 272620003964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620003965 dimerization interface [polypeptide binding]; other site 272620003966 putative DNA binding site [nucleotide binding]; other site 272620003967 putative Zn2+ binding site [ion binding]; other site 272620003968 ACT domain-containing protein [General function prediction only]; Region: COG4747 272620003969 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272620003970 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 272620003971 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 272620003972 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272620003973 NAD binding site [chemical binding]; other site 272620003974 catalytic Zn binding site [ion binding]; other site 272620003975 structural Zn binding site [ion binding]; other site 272620003976 General stress protein [General function prediction only]; Region: GsiB; COG3729 272620003977 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 272620003978 dimerization interface [polypeptide binding]; other site 272620003979 metal binding site [ion binding]; metal-binding site 272620003980 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 272620003981 dinuclear metal binding motif [ion binding]; other site 272620003982 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 272620003983 dimanganese center [ion binding]; other site 272620003984 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272620003985 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272620003986 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272620003987 Helix-turn-helix domain; Region: HTH_39; pfam14090 272620003988 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620003989 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 272620003990 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 272620003991 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620003992 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272620003993 dimerization interface [polypeptide binding]; other site 272620003994 substrate binding pocket [chemical binding]; other site 272620003995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620003996 dimerization interface [polypeptide binding]; other site 272620003997 GAF domain; Region: GAF_3; pfam13492 272620003998 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620003999 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620004000 metal binding site [ion binding]; metal-binding site 272620004001 active site 272620004002 I-site; other site 272620004003 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620004004 Zn2+ binding site [ion binding]; other site 272620004005 Mg2+ binding site [ion binding]; other site 272620004006 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620004007 Zn2+ binding site [ion binding]; other site 272620004008 Mg2+ binding site [ion binding]; other site 272620004009 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 272620004010 active site 272620004011 homotetramer interface [polypeptide binding]; other site 272620004012 homodimer interface [polypeptide binding]; other site 272620004013 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 272620004014 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272620004015 putative acyl-acceptor binding pocket; other site 272620004016 leucine export protein LeuE; Provisional; Region: PRK10958 272620004017 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 272620004018 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272620004019 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272620004020 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620004021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620004022 metal binding site [ion binding]; metal-binding site 272620004023 active site 272620004024 I-site; other site 272620004025 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 272620004026 Domain of unknown function (DUF333); Region: DUF333; pfam03891 272620004027 Uncharacterized conserved protein [Function unknown]; Region: COG3189 272620004028 Uncharacterized conserved protein [Function unknown]; Region: COG1683 272620004029 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 272620004030 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620004031 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620004032 Predicted membrane protein [Function unknown]; Region: COG2707 272620004033 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 272620004034 putative deacylase active site [active] 272620004035 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 272620004036 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272620004037 DinI-like family; Region: DinI; cl11630 272620004038 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272620004039 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272620004040 putative active site [active] 272620004041 putative NTP binding site [chemical binding]; other site 272620004042 putative nucleic acid binding site [nucleotide binding]; other site 272620004043 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272620004044 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272620004045 Catalytic site [active] 272620004046 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272620004047 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272620004048 active site 272620004049 DNA binding site [nucleotide binding] 272620004050 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272620004051 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004052 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004053 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620004054 putative effector binding pocket; other site 272620004055 putative dimerization interface [polypeptide binding]; other site 272620004056 short chain dehydrogenase; Provisional; Region: PRK06500 272620004057 classical (c) SDRs; Region: SDR_c; cd05233 272620004058 NAD(P) binding site [chemical binding]; other site 272620004059 active site 272620004060 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620004061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004063 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620004064 dimerization interface [polypeptide binding]; other site 272620004065 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272620004066 catalytic residues [active] 272620004067 dimer interface [polypeptide binding]; other site 272620004068 hypothetical protein; Provisional; Region: PRK05325 272620004069 PrkA family serine protein kinase; Provisional; Region: PRK15455 272620004070 AAA ATPase domain; Region: AAA_16; pfam13191 272620004071 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272620004072 Walker A motif; other site 272620004073 ATP binding site [chemical binding]; other site 272620004074 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 272620004075 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 272620004076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620004077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620004078 active site 272620004079 catalytic tetrad [active] 272620004080 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 272620004081 active site 272620004082 phosphate binding residues; other site 272620004083 catalytic residues [active] 272620004084 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 272620004085 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272620004086 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272620004087 methionine sulfoxide reductase B; Provisional; Region: PRK00222 272620004088 SelR domain; Region: SelR; pfam01641 272620004089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 272620004090 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620004091 active site 272620004092 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 272620004093 Glyco_18 domain; Region: Glyco_18; smart00636 272620004094 active site 272620004095 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 272620004096 Isochorismatase family; Region: Isochorismatase; pfam00857 272620004097 catalytic triad [active] 272620004098 metal binding site [ion binding]; metal-binding site 272620004099 conserved cis-peptide bond; other site 272620004100 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 272620004101 active site 272620004102 homodimer interface [polypeptide binding]; other site 272620004103 protease 4; Provisional; Region: PRK10949 272620004104 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 272620004105 tandem repeat interface [polypeptide binding]; other site 272620004106 oligomer interface [polypeptide binding]; other site 272620004107 active site residues [active] 272620004108 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 272620004109 tandem repeat interface [polypeptide binding]; other site 272620004110 oligomer interface [polypeptide binding]; other site 272620004111 active site residues [active] 272620004112 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 272620004113 putative FMN binding site [chemical binding]; other site 272620004114 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 272620004115 active site 272620004116 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272620004117 selenophosphate synthetase; Provisional; Region: PRK00943 272620004118 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 272620004119 dimerization interface [polypeptide binding]; other site 272620004120 putative ATP binding site [chemical binding]; other site 272620004121 DNA topoisomerase III; Provisional; Region: PRK07726 272620004122 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 272620004123 active site 272620004124 putative interdomain interaction site [polypeptide binding]; other site 272620004125 putative metal-binding site [ion binding]; other site 272620004126 putative nucleotide binding site [chemical binding]; other site 272620004127 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272620004128 domain I; other site 272620004129 DNA binding groove [nucleotide binding] 272620004130 phosphate binding site [ion binding]; other site 272620004131 domain II; other site 272620004132 domain III; other site 272620004133 nucleotide binding site [chemical binding]; other site 272620004134 catalytic site [active] 272620004135 domain IV; other site 272620004136 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 272620004137 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 272620004138 NAD(P) binding site [chemical binding]; other site 272620004139 glutamate dehydrogenase; Provisional; Region: PRK09414 272620004140 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 272620004141 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 272620004142 NAD(P) binding site [chemical binding]; other site 272620004143 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 272620004144 active site 272620004145 8-oxo-dGMP binding site [chemical binding]; other site 272620004146 nudix motif; other site 272620004147 metal binding site [ion binding]; metal-binding site 272620004148 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272620004149 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 272620004150 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272620004151 active site residue [active] 272620004152 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272620004153 active site residue [active] 272620004154 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 272620004155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620004156 Walker A/P-loop; other site 272620004157 ATP binding site [chemical binding]; other site 272620004158 Q-loop/lid; other site 272620004159 ABC transporter signature motif; other site 272620004160 Walker B; other site 272620004161 D-loop; other site 272620004162 H-loop/switch region; other site 272620004163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620004164 ABC-ATPase subunit interface; other site 272620004165 putative PBP binding loops; other site 272620004166 hypothetical protein; Provisional; Region: PRK11622 272620004167 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 272620004168 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272620004169 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272620004170 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272620004171 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272620004172 Uncharacterized conserved protein [Function unknown]; Region: COG0398 272620004173 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272620004174 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 272620004175 putative catalytic site [active] 272620004176 putative phosphate binding site [ion binding]; other site 272620004177 active site 272620004178 metal binding site A [ion binding]; metal-binding site 272620004179 DNA binding site [nucleotide binding] 272620004180 putative AP binding site [nucleotide binding]; other site 272620004181 putative metal binding site B [ion binding]; other site 272620004182 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 272620004183 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620004184 inhibitor-cofactor binding pocket; inhibition site 272620004185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620004186 catalytic residue [active] 272620004187 arginine succinyltransferase; Provisional; Region: PRK10456 272620004188 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 272620004189 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 272620004190 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 272620004191 NAD(P) binding site [chemical binding]; other site 272620004192 catalytic residues [active] 272620004193 succinylarginine dihydrolase; Provisional; Region: PRK13281 272620004194 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 272620004195 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 272620004196 putative active site [active] 272620004197 Zn binding site [ion binding]; other site 272620004198 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 272620004199 dimer interface [polypeptide binding]; other site 272620004200 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 272620004201 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272620004202 GIY-YIG motif/motif A; other site 272620004203 active site 272620004204 catalytic site [active] 272620004205 putative DNA binding site [nucleotide binding]; other site 272620004206 metal binding site [ion binding]; metal-binding site 272620004207 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 272620004208 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272620004209 homodimer interface [polypeptide binding]; other site 272620004210 NAD binding pocket [chemical binding]; other site 272620004211 ATP binding pocket [chemical binding]; other site 272620004212 Mg binding site [ion binding]; other site 272620004213 active-site loop [active] 272620004214 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 272620004215 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272620004216 active site 272620004217 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 272620004218 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272620004219 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272620004220 methionine cluster; other site 272620004221 active site 272620004222 phosphorylation site [posttranslational modification] 272620004223 metal binding site [ion binding]; metal-binding site 272620004224 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 272620004225 Cupin domain; Region: Cupin_2; pfam07883 272620004226 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620004227 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272620004228 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272620004229 NAD binding site [chemical binding]; other site 272620004230 sugar binding site [chemical binding]; other site 272620004231 divalent metal binding site [ion binding]; other site 272620004232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620004233 dimer interface [polypeptide binding]; other site 272620004234 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 272620004235 putative active site [active] 272620004236 YdjC motif; other site 272620004237 Mg binding site [ion binding]; other site 272620004238 putative homodimer interface [polypeptide binding]; other site 272620004239 hydroperoxidase II; Provisional; Region: katE; PRK11249 272620004240 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 272620004241 tetramer interface [polypeptide binding]; other site 272620004242 heme binding pocket [chemical binding]; other site 272620004243 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 272620004244 domain interactions; other site 272620004245 cell division modulator; Provisional; Region: PRK10113 272620004246 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 272620004247 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272620004248 inner membrane protein; Provisional; Region: PRK11648 272620004249 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 272620004250 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 272620004251 NADP binding site [chemical binding]; other site 272620004252 homodimer interface [polypeptide binding]; other site 272620004253 active site 272620004254 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 272620004255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620004256 motif II; other site 272620004257 YniB-like protein; Region: YniB; pfam14002 272620004258 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 272620004259 outer membrane receptor FepA; Provisional; Region: PRK13528 272620004260 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620004261 N-terminal plug; other site 272620004262 ligand-binding site [chemical binding]; other site 272620004263 intracellular septation protein A; Reviewed; Region: PRK00259 272620004264 hypothetical protein; Provisional; Region: PRK02868 272620004265 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 272620004266 outer membrane protein W; Provisional; Region: PRK10959 272620004267 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 272620004268 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 272620004269 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620004270 N-terminal plug; other site 272620004271 ligand-binding site [chemical binding]; other site 272620004272 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272620004273 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 272620004274 putative NAD(P) binding site [chemical binding]; other site 272620004275 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620004276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620004277 putative DNA binding site [nucleotide binding]; other site 272620004278 putative Zn2+ binding site [ion binding]; other site 272620004279 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 272620004280 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 272620004281 substrate binding site [chemical binding]; other site 272620004282 active site 272620004283 catalytic residues [active] 272620004284 heterodimer interface [polypeptide binding]; other site 272620004285 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 272620004286 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 272620004287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620004288 catalytic residue [active] 272620004289 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 272620004290 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 272620004291 active site 272620004292 ribulose/triose binding site [chemical binding]; other site 272620004293 phosphate binding site [ion binding]; other site 272620004294 substrate (anthranilate) binding pocket [chemical binding]; other site 272620004295 product (indole) binding pocket [chemical binding]; other site 272620004296 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 272620004297 active site 272620004298 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 272620004299 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272620004300 glutamine binding [chemical binding]; other site 272620004301 catalytic triad [active] 272620004302 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272620004303 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272620004304 anthranilate synthase component I; Provisional; Region: PRK13564 272620004305 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272620004306 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 272620004307 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 272620004308 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272620004309 active site 272620004310 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 272620004311 hypothetical protein; Provisional; Region: PRK11630 272620004312 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272620004313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004314 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620004315 dimerization interface [polypeptide binding]; other site 272620004316 substrate binding pocket [chemical binding]; other site 272620004317 PAAR motif; Region: PAAR_motif; pfam05488 272620004318 PAAR motif; Region: PAAR_motif; pfam05488 272620004319 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 272620004320 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620004321 RNA binding surface [nucleotide binding]; other site 272620004322 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 272620004323 probable active site [active] 272620004324 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 272620004325 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 272620004326 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 272620004327 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 272620004328 NADP binding site [chemical binding]; other site 272620004329 homodimer interface [polypeptide binding]; other site 272620004330 active site 272620004331 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 272620004332 putative inner membrane peptidase; Provisional; Region: PRK11778 272620004333 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 272620004334 tandem repeat interface [polypeptide binding]; other site 272620004335 oligomer interface [polypeptide binding]; other site 272620004336 active site residues [active] 272620004337 hypothetical protein; Provisional; Region: PRK11037 272620004338 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 272620004339 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272620004340 active site 272620004341 interdomain interaction site; other site 272620004342 putative metal-binding site [ion binding]; other site 272620004343 nucleotide binding site [chemical binding]; other site 272620004344 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272620004345 domain I; other site 272620004346 DNA binding groove [nucleotide binding] 272620004347 phosphate binding site [ion binding]; other site 272620004348 domain II; other site 272620004349 domain III; other site 272620004350 nucleotide binding site [chemical binding]; other site 272620004351 catalytic site [active] 272620004352 domain IV; other site 272620004353 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272620004354 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272620004355 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 272620004356 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 272620004357 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 272620004358 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004359 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 272620004360 substrate binding site [chemical binding]; other site 272620004361 putative dimerization interface [polypeptide binding]; other site 272620004362 aconitate hydratase; Validated; Region: PRK09277 272620004363 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 272620004364 substrate binding site [chemical binding]; other site 272620004365 ligand binding site [chemical binding]; other site 272620004366 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 272620004367 substrate binding site [chemical binding]; other site 272620004368 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 272620004369 dimerization interface [polypeptide binding]; other site 272620004370 active site 272620004371 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272620004372 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272620004373 active site 272620004374 Predicted membrane protein [Function unknown]; Region: COG3771 272620004375 tetratricopeptide repeat protein; Provisional; Region: PRK11788 272620004376 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272620004377 binding surface 272620004378 TPR motif; other site 272620004379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620004380 binding surface 272620004381 TPR motif; other site 272620004382 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272620004383 active site 272620004384 dimer interface [polypeptide binding]; other site 272620004385 translation initiation factor Sui1; Validated; Region: PRK06824 272620004386 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 272620004387 putative rRNA binding site [nucleotide binding]; other site 272620004388 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620004389 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620004390 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620004391 hypothetical protein; Provisional; Region: PRK13658 272620004392 exoribonuclease II; Provisional; Region: PRK05054 272620004393 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272620004394 RNB domain; Region: RNB; pfam00773 272620004395 S1 RNA binding domain; Region: S1; pfam00575 272620004396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 272620004397 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272620004398 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 272620004399 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 272620004400 NAD binding site [chemical binding]; other site 272620004401 homotetramer interface [polypeptide binding]; other site 272620004402 homodimer interface [polypeptide binding]; other site 272620004403 substrate binding site [chemical binding]; other site 272620004404 active site 272620004405 HutD; Region: HutD; pfam05962 272620004406 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272620004407 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 272620004408 Na binding site [ion binding]; other site 272620004409 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 272620004410 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620004411 Walker A/P-loop; other site 272620004412 ATP binding site [chemical binding]; other site 272620004413 Q-loop/lid; other site 272620004414 ABC transporter signature motif; other site 272620004415 Walker B; other site 272620004416 D-loop; other site 272620004417 H-loop/switch region; other site 272620004418 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 272620004419 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620004420 Walker A/P-loop; other site 272620004421 ATP binding site [chemical binding]; other site 272620004422 Q-loop/lid; other site 272620004423 ABC transporter signature motif; other site 272620004424 Walker B; other site 272620004425 D-loop; other site 272620004426 H-loop/switch region; other site 272620004427 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620004428 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 272620004429 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620004430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620004431 dimer interface [polypeptide binding]; other site 272620004432 conserved gate region; other site 272620004433 putative PBP binding loops; other site 272620004434 ABC-ATPase subunit interface; other site 272620004435 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 272620004436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620004437 dimer interface [polypeptide binding]; other site 272620004438 conserved gate region; other site 272620004439 putative PBP binding loops; other site 272620004440 ABC-ATPase subunit interface; other site 272620004441 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272620004442 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 272620004443 peptide binding site [polypeptide binding]; other site 272620004444 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620004445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620004446 salt bridge; other site 272620004447 non-specific DNA binding site [nucleotide binding]; other site 272620004448 sequence-specific DNA binding site [nucleotide binding]; other site 272620004449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620004450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620004451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620004452 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 272620004453 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272620004454 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272620004455 metal binding site [ion binding]; metal-binding site 272620004456 putative dimer interface [polypeptide binding]; other site 272620004457 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620004458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620004459 putative substrate translocation pore; other site 272620004460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620004461 putative substrate translocation pore; other site 272620004462 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 272620004463 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620004464 Walker A motif; other site 272620004465 ATP binding site [chemical binding]; other site 272620004466 Walker B motif; other site 272620004467 arginine finger; other site 272620004468 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620004469 phage shock protein PspA; Provisional; Region: PRK10698 272620004470 phage shock protein B; Provisional; Region: pspB; PRK09458 272620004471 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 272620004472 phage shock protein C; Region: phageshock_pspC; TIGR02978 272620004473 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 272620004474 Predicted ATPase [General function prediction only]; Region: COG3106 272620004475 hypothetical protein; Provisional; Region: PRK05415 272620004476 Domain of unknown function (DUF697); Region: DUF697; cl12064 272620004477 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 272620004478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004479 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620004480 dimerization interface [polypeptide binding]; other site 272620004481 substrate binding pocket [chemical binding]; other site 272620004482 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272620004483 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272620004484 NAD binding site [chemical binding]; other site 272620004485 sugar binding site [chemical binding]; other site 272620004486 divalent metal binding site [ion binding]; other site 272620004487 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620004488 dimer interface [polypeptide binding]; other site 272620004489 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 272620004490 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272620004491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272620004492 putative active site [active] 272620004493 heme pocket [chemical binding]; other site 272620004494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620004495 Walker A motif; other site 272620004496 ATP binding site [chemical binding]; other site 272620004497 Walker B motif; other site 272620004498 arginine finger; other site 272620004499 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272620004500 Putative ammonia monooxygenase; Region: AmoA; pfam05145 272620004501 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 272620004502 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 272620004503 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 272620004504 active site 272620004505 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 272620004506 putative active site [active] 272620004507 Zn binding site [ion binding]; other site 272620004508 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 272620004509 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272620004510 peptide binding site [polypeptide binding]; other site 272620004511 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 272620004512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004514 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 272620004515 putative effector binding pocket; other site 272620004516 putative dimerization interface [polypeptide binding]; other site 272620004517 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 272620004518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620004519 putative substrate translocation pore; other site 272620004520 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620004521 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620004522 active site 272620004523 catalytic tetrad [active] 272620004524 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 272620004525 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004527 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620004528 putative effector binding pocket; other site 272620004529 putative dimerization interface [polypeptide binding]; other site 272620004530 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272620004531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620004532 NAD(P) binding site [chemical binding]; other site 272620004533 active site 272620004534 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272620004535 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620004536 Zn2+ binding site [ion binding]; other site 272620004537 Mg2+ binding site [ion binding]; other site 272620004538 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 272620004539 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272620004540 conserved cys residue [active] 272620004541 Protein of unknown function (DUF770); Region: DUF770; pfam05591 272620004542 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 272620004543 Protein of unknown function (DUF877); Region: DUF877; pfam05943 272620004544 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 272620004545 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 272620004546 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 272620004547 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272620004548 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620004549 ligand binding site [chemical binding]; other site 272620004550 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 272620004551 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 272620004552 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620004553 Walker A motif; other site 272620004554 ATP binding site [chemical binding]; other site 272620004555 Walker B motif; other site 272620004556 arginine finger; other site 272620004557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620004558 Walker A motif; other site 272620004559 ATP binding site [chemical binding]; other site 272620004560 Walker B motif; other site 272620004561 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272620004562 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 272620004563 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 272620004564 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 272620004565 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 272620004566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 272620004567 Peptidase family M23; Region: Peptidase_M23; pfam01551 272620004568 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272620004569 DNA-binding interface [nucleotide binding]; DNA binding site 272620004570 Winged helix-turn helix; Region: HTH_29; pfam13551 272620004571 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272620004572 Integrase core domain; Region: rve; pfam00665 272620004573 Integrase core domain; Region: rve_3; pfam13683 272620004574 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 272620004575 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 272620004576 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 272620004577 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 272620004578 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 272620004579 PAAR motif; Region: PAAR_motif; pfam05488 272620004580 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 272620004581 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272620004582 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 272620004583 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 272620004584 oxidoreductase; Provisional; Region: PRK12742 272620004585 classical (c) SDRs; Region: SDR_c; cd05233 272620004586 NAD(P) binding site [chemical binding]; other site 272620004587 active site 272620004588 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620004589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620004590 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 272620004591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620004592 NAD(P) binding site [chemical binding]; other site 272620004593 active site 272620004594 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272620004595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620004596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620004597 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 272620004598 NmrA-like family; Region: NmrA; pfam05368 272620004599 NAD(P) binding site [chemical binding]; other site 272620004600 active site lysine 272620004601 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004602 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004603 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620004604 putative effector binding pocket; other site 272620004605 putative dimerization interface [polypeptide binding]; other site 272620004606 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004607 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004608 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 272620004609 putative substrate binding pocket [chemical binding]; other site 272620004610 putative dimerization interface [polypeptide binding]; other site 272620004611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272620004612 NmrA-like family; Region: NmrA; pfam05368 272620004613 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 272620004614 NADP binding site [chemical binding]; other site 272620004615 active site 272620004616 regulatory binding site [polypeptide binding]; other site 272620004617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620004618 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272620004619 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 272620004620 putative NAD(P) binding site [chemical binding]; other site 272620004621 transaminase; Reviewed; Region: PRK08068 272620004622 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620004623 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620004624 homodimer interface [polypeptide binding]; other site 272620004625 catalytic residue [active] 272620004626 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272620004627 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272620004628 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 272620004629 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272620004630 Walker A/P-loop; other site 272620004631 ATP binding site [chemical binding]; other site 272620004632 Q-loop/lid; other site 272620004633 ABC transporter signature motif; other site 272620004634 Walker B; other site 272620004635 D-loop; other site 272620004636 H-loop/switch region; other site 272620004637 NIL domain; Region: NIL; pfam09383 272620004638 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 272620004639 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 272620004640 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620004641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620004642 homodimer interface [polypeptide binding]; other site 272620004643 catalytic residue [active] 272620004644 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272620004645 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272620004646 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272620004647 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272620004648 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 272620004649 putative DNA binding site [nucleotide binding]; other site 272620004650 putative Zn2+ binding site [ion binding]; other site 272620004651 AsnC family; Region: AsnC_trans_reg; pfam01037 272620004652 aromatic amino acid transporter; Provisional; Region: PRK10238 272620004653 putative oxidoreductase; Provisional; Region: PRK11579 272620004654 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620004655 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620004656 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620004657 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620004658 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620004659 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272620004660 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 272620004661 Cl binding site [ion binding]; other site 272620004662 oligomer interface [polypeptide binding]; other site 272620004663 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 272620004664 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272620004665 ATP binding site [chemical binding]; other site 272620004666 Mg++ binding site [ion binding]; other site 272620004667 motif III; other site 272620004668 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620004669 nucleotide binding region [chemical binding]; other site 272620004670 ATP-binding site [chemical binding]; other site 272620004671 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 272620004672 putative RNA binding site [nucleotide binding]; other site 272620004673 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 272620004674 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 272620004675 Ligand Binding Site [chemical binding]; other site 272620004676 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 272620004677 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272620004678 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272620004679 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 272620004680 Int/Topo IB signature motif; other site 272620004681 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 272620004682 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 272620004683 Protein of unknown function (DUF550); Region: DUF550; pfam04447 272620004684 RecT family; Region: RecT; cl04285 272620004685 exonuclease VIII; Reviewed; Region: PRK09709 272620004686 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 272620004687 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 272620004688 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 272620004689 active site 272620004690 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 272620004691 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 272620004692 primosomal protein DnaI; Provisional; Region: PRK02854 272620004693 putative replication protein; Provisional; Region: PRK12377 272620004694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620004695 ATP binding site [chemical binding]; other site 272620004696 Walker A motif; other site 272620004697 Walker B motif; other site 272620004698 arginine finger; other site 272620004699 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272620004700 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272620004701 cofactor binding site; other site 272620004702 DNA binding site [nucleotide binding] 272620004703 substrate interaction site [chemical binding]; other site 272620004704 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272620004705 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272620004706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620004707 Coenzyme A binding pocket [chemical binding]; other site 272620004708 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 272620004709 Antitermination protein; Region: Antiterm; pfam03589 272620004710 Antitermination protein; Region: Antiterm; pfam03589 272620004711 Protein of unknown function (DUF754); Region: DUF754; pfam05449 272620004712 Predicted chitinase [General function prediction only]; Region: COG3179 272620004713 catalytic residue [active] 272620004714 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 272620004715 Terminase small subunit; Region: Terminase_2; pfam03592 272620004716 Phage terminase large subunit; Region: Terminase_3; cl12054 272620004717 Terminase-like family; Region: Terminase_6; pfam03237 272620004718 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 272620004719 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 272620004720 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 272620004721 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 272620004722 Phage-related minor tail protein [Function unknown]; Region: COG5281 272620004723 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 272620004724 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 272620004725 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272620004726 active site 272620004727 oxyanion hole [active] 272620004728 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272620004729 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 272620004730 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272620004731 DNA-binding interface [nucleotide binding]; DNA binding site 272620004732 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272620004733 DNA binding site [nucleotide binding] 272620004734 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272620004735 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272620004736 Catalytic site [active] 272620004737 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272620004738 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272620004739 DNA binding site [nucleotide binding] 272620004740 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272620004741 hypothetical protein; Provisional; Region: PRK09951 272620004742 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620004743 Ligand Binding Site [chemical binding]; other site 272620004744 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 272620004745 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 272620004746 trimer interface [polypeptide binding]; other site 272620004747 eyelet of channel; other site 272620004748 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 272620004749 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 272620004750 dimer interface [polypeptide binding]; other site 272620004751 PYR/PP interface [polypeptide binding]; other site 272620004752 TPP binding site [chemical binding]; other site 272620004753 substrate binding site [chemical binding]; other site 272620004754 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 272620004755 Domain of unknown function; Region: EKR; pfam10371 272620004756 4Fe-4S binding domain; Region: Fer4_6; pfam12837 272620004757 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272620004758 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 272620004759 TPP-binding site [chemical binding]; other site 272620004760 dimer interface [polypeptide binding]; other site 272620004761 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 272620004762 Domain of unknown function (DUF333); Region: DUF333; pfam03891 272620004763 META domain; Region: META; cl01245 272620004764 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 272620004765 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272620004766 putative ligand binding site [chemical binding]; other site 272620004767 putative NAD binding site [chemical binding]; other site 272620004768 catalytic site [active] 272620004769 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272620004770 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272620004771 hypothetical protein; Provisional; Region: PRK10695 272620004772 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 272620004773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 272620004774 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 272620004775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620004776 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272620004777 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272620004778 NAD(P) binding site [chemical binding]; other site 272620004779 catalytic residues [active] 272620004780 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 272620004781 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 272620004782 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 272620004783 hypothetical protein; Provisional; Region: PRK07490 272620004784 intersubunit interface [polypeptide binding]; other site 272620004785 active site 272620004786 Zn2+ binding site [ion binding]; other site 272620004787 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620004788 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620004789 substrate binding pocket [chemical binding]; other site 272620004790 membrane-bound complex binding site; other site 272620004791 hinge residues; other site 272620004792 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 272620004793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620004794 dimer interface [polypeptide binding]; other site 272620004795 conserved gate region; other site 272620004796 putative PBP binding loops; other site 272620004797 ABC-ATPase subunit interface; other site 272620004798 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620004799 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620004800 Walker A/P-loop; other site 272620004801 ATP binding site [chemical binding]; other site 272620004802 Q-loop/lid; other site 272620004803 ABC transporter signature motif; other site 272620004804 Walker B; other site 272620004805 D-loop; other site 272620004806 H-loop/switch region; other site 272620004807 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004808 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004809 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 272620004810 putative substrate binding pocket [chemical binding]; other site 272620004811 dimerization interface [polypeptide binding]; other site 272620004812 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 272620004813 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620004814 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272620004815 homotrimer interaction site [polypeptide binding]; other site 272620004816 putative active site [active] 272620004817 acetylornithine deacetylase; Provisional; Region: PRK07522 272620004818 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 272620004819 metal binding site [ion binding]; metal-binding site 272620004820 putative dimer interface [polypeptide binding]; other site 272620004821 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 272620004822 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272620004823 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 272620004824 NADP binding site [chemical binding]; other site 272620004825 dimer interface [polypeptide binding]; other site 272620004826 tyramine oxidase; Provisional; Region: tynA; PRK14696 272620004827 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 272620004828 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 272620004829 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 272620004830 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 272620004831 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 272620004832 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 272620004833 substrate binding site [chemical binding]; other site 272620004834 dimer interface [polypeptide binding]; other site 272620004835 NADP binding site [chemical binding]; other site 272620004836 catalytic residues [active] 272620004837 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 272620004838 substrate binding site [chemical binding]; other site 272620004839 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 272620004840 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 272620004841 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 272620004842 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 272620004843 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 272620004844 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 272620004845 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 272620004846 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 272620004847 FAD binding pocket [chemical binding]; other site 272620004848 FAD binding motif [chemical binding]; other site 272620004849 phosphate binding motif [ion binding]; other site 272620004850 beta-alpha-beta structure motif; other site 272620004851 NAD(p) ribose binding residues [chemical binding]; other site 272620004852 NAD binding pocket [chemical binding]; other site 272620004853 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 272620004854 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620004855 catalytic loop [active] 272620004856 iron binding site [ion binding]; other site 272620004857 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 272620004858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272620004859 substrate binding site [chemical binding]; other site 272620004860 oxyanion hole (OAH) forming residues; other site 272620004861 trimer interface [polypeptide binding]; other site 272620004862 enoyl-CoA hydratase; Provisional; Region: PRK08140 272620004863 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272620004864 substrate binding site [chemical binding]; other site 272620004865 oxyanion hole (OAH) forming residues; other site 272620004866 trimer interface [polypeptide binding]; other site 272620004867 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 272620004868 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272620004869 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620004870 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620004871 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272620004872 CoenzymeA binding site [chemical binding]; other site 272620004873 subunit interaction site [polypeptide binding]; other site 272620004874 PHB binding site; other site 272620004875 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 272620004876 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620004877 dimer interface [polypeptide binding]; other site 272620004878 active site 272620004879 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 272620004880 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 272620004881 active site 272620004882 AMP binding site [chemical binding]; other site 272620004883 homodimer interface [polypeptide binding]; other site 272620004884 acyl-activating enzyme (AAE) consensus motif; other site 272620004885 CoA binding site [chemical binding]; other site 272620004886 PaaX-like protein; Region: PaaX; pfam07848 272620004887 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 272620004888 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 272620004889 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 272620004890 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 272620004891 putative trimer interface [polypeptide binding]; other site 272620004892 putative metal binding site [ion binding]; other site 272620004893 Uncharacterized conserved protein [Function unknown]; Region: COG3791 272620004894 azoreductase; Reviewed; Region: PRK00170 272620004895 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272620004896 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 272620004897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620004898 ATP binding site [chemical binding]; other site 272620004899 putative Mg++ binding site [ion binding]; other site 272620004900 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620004901 nucleotide binding region [chemical binding]; other site 272620004902 ATP-binding site [chemical binding]; other site 272620004903 Helicase associated domain (HA2); Region: HA2; pfam04408 272620004904 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 272620004905 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 272620004906 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 272620004907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620004908 S-adenosylmethionine binding site [chemical binding]; other site 272620004909 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 272620004910 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272620004911 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620004912 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620004913 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620004914 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620004915 putative substrate translocation pore; other site 272620004916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620004917 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 272620004918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620004919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620004920 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620004921 dimerization interface [polypeptide binding]; other site 272620004922 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620004923 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620004924 active site 272620004925 catalytic tetrad [active] 272620004926 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 272620004927 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 272620004928 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 272620004929 NAD(P) binding site [chemical binding]; other site 272620004930 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 272620004931 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620004932 inhibitor-cofactor binding pocket; inhibition site 272620004933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620004934 catalytic residue [active] 272620004935 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 272620004936 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 272620004937 succinylarginine dihydrolase; Provisional; Region: PRK13281 272620004938 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 272620004939 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 272620004940 putative active site [active] 272620004941 Zn binding site [ion binding]; other site 272620004942 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 272620004943 shikimate transporter; Provisional; Region: PRK09952 272620004944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620004945 putative substrate translocation pore; other site 272620004946 Uncharacterized conserved protein [Function unknown]; Region: COG1434 272620004947 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272620004948 putative active site [active] 272620004949 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 272620004950 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272620004951 NAD binding site [chemical binding]; other site 272620004952 catalytic residues [active] 272620004953 substrate binding site [chemical binding]; other site 272620004954 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272620004955 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272620004956 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272620004957 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 272620004958 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 272620004959 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 272620004960 CPxP motif; other site 272620004961 putative inner membrane protein; Provisional; Region: PRK11099 272620004962 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 272620004963 YdfZ protein; Region: YdfZ; pfam14001 272620004964 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272620004965 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 272620004966 Cl binding site [ion binding]; other site 272620004967 oligomer interface [polypeptide binding]; other site 272620004968 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 272620004969 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620004970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620004971 homodimer interface [polypeptide binding]; other site 272620004972 catalytic residue [active] 272620004973 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 272620004974 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 272620004975 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620004976 active site turn [active] 272620004977 phosphorylation site [posttranslational modification] 272620004978 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 272620004979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620004980 DNA binding site [nucleotide binding] 272620004981 domain linker motif; other site 272620004982 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 272620004983 putative dimerization interface [polypeptide binding]; other site 272620004984 putative ligand binding site [chemical binding]; other site 272620004985 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 272620004986 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 272620004987 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 272620004988 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 272620004989 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 272620004990 fumarate hydratase; Provisional; Region: PRK15389 272620004991 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 272620004992 Fumarase C-terminus; Region: Fumerase_C; pfam05683 272620004993 fumarate hydratase; Reviewed; Region: fumC; PRK00485 272620004994 Class II fumarases; Region: Fumarase_classII; cd01362 272620004995 active site 272620004996 tetramer interface [polypeptide binding]; other site 272620004997 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 272620004998 sensor protein RstB; Provisional; Region: PRK10604 272620004999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620005000 dimerization interface [polypeptide binding]; other site 272620005001 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620005002 dimer interface [polypeptide binding]; other site 272620005003 phosphorylation site [posttranslational modification] 272620005004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620005005 ATP binding site [chemical binding]; other site 272620005006 Mg2+ binding site [ion binding]; other site 272620005007 G-X-G motif; other site 272620005008 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 272620005009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620005010 active site 272620005011 phosphorylation site [posttranslational modification] 272620005012 intermolecular recognition site; other site 272620005013 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620005014 DNA binding site [nucleotide binding] 272620005015 GlpM protein; Region: GlpM; pfam06942 272620005016 dihydromonapterin reductase; Provisional; Region: PRK06483 272620005017 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 272620005018 NADP binding site [chemical binding]; other site 272620005019 substrate binding pocket [chemical binding]; other site 272620005020 active site 272620005021 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 272620005022 Spore germination protein; Region: Spore_permease; cl17796 272620005023 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620005024 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620005025 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620005026 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 272620005027 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 272620005028 ligand binding site [chemical binding]; other site 272620005029 homodimer interface [polypeptide binding]; other site 272620005030 NAD(P) binding site [chemical binding]; other site 272620005031 trimer interface B [polypeptide binding]; other site 272620005032 trimer interface A [polypeptide binding]; other site 272620005033 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 272620005034 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 272620005035 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 272620005036 universal stress protein UspE; Provisional; Region: PRK11175 272620005037 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620005038 Ligand Binding Site [chemical binding]; other site 272620005039 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620005040 Ligand Binding Site [chemical binding]; other site 272620005041 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 272620005042 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272620005043 putative switch regulator; other site 272620005044 non-specific DNA interactions [nucleotide binding]; other site 272620005045 DNA binding site [nucleotide binding] 272620005046 sequence specific DNA binding site [nucleotide binding]; other site 272620005047 putative cAMP binding site [chemical binding]; other site 272620005048 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 272620005049 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 272620005050 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272620005051 DNA binding site [nucleotide binding] 272620005052 active site 272620005053 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 272620005054 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 272620005055 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 272620005056 amidohydrolase; Region: amidohydrolases; TIGR01891 272620005057 putative metal binding site [ion binding]; other site 272620005058 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 272620005059 amidohydrolase; Region: amidohydrolases; TIGR01891 272620005060 putative metal binding site [ion binding]; other site 272620005061 dimer interface [polypeptide binding]; other site 272620005062 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 272620005063 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005064 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620005065 dimerization interface [polypeptide binding]; other site 272620005066 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 272620005067 Smr domain; Region: Smr; pfam01713 272620005068 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 272620005069 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620005070 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620005071 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 272620005072 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 272620005073 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 272620005074 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620005075 dimer interface [polypeptide binding]; other site 272620005076 active site 272620005077 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 272620005078 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 272620005079 tetramer interface [polypeptide binding]; other site 272620005080 active site 272620005081 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 272620005082 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272620005083 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 272620005084 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 272620005085 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620005086 fumarate hydratase; Provisional; Region: PRK15389 272620005087 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 272620005088 Fumarase C-terminus; Region: Fumerase_C; pfam05683 272620005089 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272620005090 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 272620005091 transmembrane helices; other site 272620005092 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272620005093 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 272620005094 putative active site [active] 272620005095 putative FMN binding site [chemical binding]; other site 272620005096 putative substrate binding site [chemical binding]; other site 272620005097 putative catalytic residue [active] 272620005098 FMN-binding domain; Region: FMN_bind; cl01081 272620005099 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 272620005100 L-aspartate oxidase; Provisional; Region: PRK06175 272620005101 Predicted oxidoreductase [General function prediction only]; Region: COG3573 272620005102 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 272620005103 ApbE family; Region: ApbE; pfam02424 272620005104 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 272620005105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620005106 active site 272620005107 phosphorylation site [posttranslational modification] 272620005108 intermolecular recognition site; other site 272620005109 dimerization interface [polypeptide binding]; other site 272620005110 sensory histidine kinase DcuS; Provisional; Region: PRK11086 272620005111 PAS domain; Region: PAS; smart00091 272620005112 putative active site [active] 272620005113 heme pocket [chemical binding]; other site 272620005114 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620005115 ATP binding site [chemical binding]; other site 272620005116 Mg2+ binding site [ion binding]; other site 272620005117 G-X-G motif; other site 272620005118 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272620005119 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272620005120 putative active site [active] 272620005121 malate:quinone oxidoreductase; Validated; Region: PRK05257 272620005122 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 272620005123 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005124 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620005126 dimerization interface [polypeptide binding]; other site 272620005127 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 272620005128 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 272620005129 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 272620005130 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 272620005131 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 272620005132 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 272620005133 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 272620005134 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 272620005135 Coenzyme A transferase; Region: CoA_trans; cl17247 272620005136 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 272620005137 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272620005138 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 272620005139 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 272620005140 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 272620005141 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 272620005142 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 272620005143 active site 272620005144 Zn binding site [ion binding]; other site 272620005145 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620005146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005147 putative substrate translocation pore; other site 272620005148 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 272620005149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005150 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272620005151 dimerization interface [polypeptide binding]; other site 272620005152 substrate binding pocket [chemical binding]; other site 272620005153 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 272620005154 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272620005155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620005156 nucleotide binding site [chemical binding]; other site 272620005157 putative dithiobiotin synthetase; Provisional; Region: PRK12374 272620005158 AAA domain; Region: AAA_26; pfam13500 272620005159 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 272620005160 Cl- selectivity filter; other site 272620005161 Cl- binding residues [ion binding]; other site 272620005162 pore gating glutamate residue; other site 272620005163 dimer interface [polypeptide binding]; other site 272620005164 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 272620005165 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 272620005166 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 272620005167 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 272620005168 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 272620005169 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 272620005170 putative [Fe4-S4] binding site [ion binding]; other site 272620005171 putative molybdopterin cofactor binding site [chemical binding]; other site 272620005172 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 272620005173 putative molybdopterin cofactor binding site; other site 272620005174 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 272620005175 lipoprotein; Reviewed; Region: PRK02939 272620005176 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 272620005177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620005178 Coenzyme A binding pocket [chemical binding]; other site 272620005179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272620005180 hypothetical protein; Provisional; Region: PRK13659 272620005181 hypothetical protein; Provisional; Region: PRK02237 272620005182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005183 D-galactonate transporter; Region: 2A0114; TIGR00893 272620005184 putative substrate translocation pore; other site 272620005185 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272620005186 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272620005187 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272620005188 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620005189 Ligand Binding Site [chemical binding]; other site 272620005190 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272620005191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620005192 DNA-binding site [nucleotide binding]; DNA binding site 272620005193 FCD domain; Region: FCD; pfam07729 272620005194 malonic semialdehyde reductase; Provisional; Region: PRK10538 272620005195 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 272620005196 putative NAD(P) binding site [chemical binding]; other site 272620005197 homodimer interface [polypeptide binding]; other site 272620005198 homotetramer interface [polypeptide binding]; other site 272620005199 active site 272620005200 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 272620005201 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272620005202 active site 272620005203 Zn binding site [ion binding]; other site 272620005204 SnoaL-like domain; Region: SnoaL_2; pfam12680 272620005205 Cupin domain; Region: Cupin_2; cl17218 272620005206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005207 Helix-turn-helix domain; Region: HTH_18; pfam12833 272620005208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005209 hypothetical protein; Provisional; Region: PRK09951 272620005210 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620005211 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620005212 DNA binding residues [nucleotide binding] 272620005213 dimerization interface [polypeptide binding]; other site 272620005214 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272620005215 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 272620005216 hypothetical protein; Validated; Region: PRK03657 272620005217 Sensors of blue-light using FAD; Region: BLUF; smart01034 272620005218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620005219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620005220 DNA binding residues [nucleotide binding] 272620005221 dimerization interface [polypeptide binding]; other site 272620005222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620005223 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 272620005224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005225 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 272620005226 putative transporter; Provisional; Region: PRK09821 272620005227 GntP family permease; Region: GntP_permease; pfam02447 272620005228 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 272620005229 putative aldolase; Validated; Region: PRK08130 272620005230 active site 272620005231 intersubunit interface [polypeptide binding]; other site 272620005232 Zn2+ binding site [ion binding]; other site 272620005233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272620005234 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272620005235 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272620005236 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620005237 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620005238 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620005239 beta-lactamase TEM; Provisional; Region: PRK15442 272620005240 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272620005241 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 272620005242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005243 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 272620005244 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272620005245 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272620005246 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 272620005247 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 272620005248 lac repressor; Reviewed; Region: lacI; PRK09526 272620005249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620005250 DNA binding site [nucleotide binding] 272620005251 domain linker motif; other site 272620005252 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 272620005253 ligand binding site [chemical binding]; other site 272620005254 dimerization interface (open form) [polypeptide binding]; other site 272620005255 dimerization interface (closed form) [polypeptide binding]; other site 272620005256 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 272620005257 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 272620005258 conserved cys residue [active] 272620005259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005261 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272620005262 substrate binding site [chemical binding]; other site 272620005263 THF binding site; other site 272620005264 zinc-binding site [ion binding]; other site 272620005265 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 272620005266 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 272620005267 putative ligand binding site [chemical binding]; other site 272620005268 HEAT repeats; Region: HEAT_2; pfam13646 272620005269 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272620005270 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620005271 TM-ABC transporter signature motif; other site 272620005272 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 272620005273 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272620005274 TM-ABC transporter signature motif; other site 272620005275 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 272620005276 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272620005277 Walker A/P-loop; other site 272620005278 ATP binding site [chemical binding]; other site 272620005279 Q-loop/lid; other site 272620005280 ABC transporter signature motif; other site 272620005281 Walker B; other site 272620005282 D-loop; other site 272620005283 H-loop/switch region; other site 272620005284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620005285 ABC transporter signature motif; other site 272620005286 Walker B; other site 272620005287 D-loop; other site 272620005288 H-loop/switch region; other site 272620005289 putative transporter; Provisional; Region: PRK10054 272620005290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005291 putative substrate translocation pore; other site 272620005292 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 272620005293 MarB protein; Region: MarB; pfam13999 272620005294 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 272620005295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005297 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 272620005298 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620005299 inner membrane protein; Provisional; Region: PRK10995 272620005300 putative arabinose transporter; Provisional; Region: PRK03545 272620005301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005302 putative substrate translocation pore; other site 272620005303 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 272620005304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620005305 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272620005306 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620005307 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272620005308 NAD binding site [chemical binding]; other site 272620005309 dimer interface [polypeptide binding]; other site 272620005310 substrate binding site [chemical binding]; other site 272620005311 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620005312 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 272620005313 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005314 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 272620005315 putative dimerization interface [polypeptide binding]; other site 272620005316 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 272620005317 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272620005318 NAD(P) binding site [chemical binding]; other site 272620005319 catalytic residues [active] 272620005320 glutaminase; Provisional; Region: PRK00971 272620005321 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 272620005322 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 272620005323 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620005324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620005325 metal binding site [ion binding]; metal-binding site 272620005326 active site 272620005327 I-site; other site 272620005328 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 272620005329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620005330 Coenzyme A binding pocket [chemical binding]; other site 272620005331 altronate oxidoreductase; Provisional; Region: PRK03643 272620005332 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272620005333 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272620005334 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272620005335 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 272620005336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620005337 S-adenosylmethionine binding site [chemical binding]; other site 272620005338 major facilitator superfamily transporter; Provisional; Region: PRK05122 272620005339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005340 putative substrate translocation pore; other site 272620005341 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 272620005342 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620005345 dimerization interface [polypeptide binding]; other site 272620005346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620005347 dimer interface [polypeptide binding]; other site 272620005348 conserved gate region; other site 272620005349 ABC-ATPase subunit interface; other site 272620005350 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620005351 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 272620005352 Walker A/P-loop; other site 272620005353 ATP binding site [chemical binding]; other site 272620005354 Q-loop/lid; other site 272620005355 ABC transporter signature motif; other site 272620005356 Walker B; other site 272620005357 D-loop; other site 272620005358 H-loop/switch region; other site 272620005359 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 272620005360 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 272620005361 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 272620005362 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 272620005363 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 272620005364 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 272620005365 Cupin domain; Region: Cupin_2; cl17218 272620005366 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 272620005367 Cupin; Region: Cupin_6; pfam12852 272620005368 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005369 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620005370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005371 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 272620005372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005373 putative substrate translocation pore; other site 272620005374 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 272620005375 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272620005376 FMN-binding pocket [chemical binding]; other site 272620005377 flavin binding motif; other site 272620005378 phosphate binding motif [ion binding]; other site 272620005379 beta-alpha-beta structure motif; other site 272620005380 NAD binding pocket [chemical binding]; other site 272620005381 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620005382 catalytic loop [active] 272620005383 iron binding site [ion binding]; other site 272620005384 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005385 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005386 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272620005387 dimerization interface [polypeptide binding]; other site 272620005388 hypothetical protein; Provisional; Region: PRK07236 272620005389 FAD binding domain; Region: FAD_binding_3; pfam01494 272620005390 xanthine permease; Region: pbuX; TIGR03173 272620005391 OHCU decarboxylase; Region: UraD_2; TIGR03180 272620005392 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 272620005393 active site 272620005394 homotetramer interface [polypeptide binding]; other site 272620005395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620005396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620005397 non-specific DNA binding site [nucleotide binding]; other site 272620005398 salt bridge; other site 272620005399 sequence-specific DNA binding site [nucleotide binding]; other site 272620005400 HipA N-terminal domain; Region: Couple_hipA; pfam13657 272620005401 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 272620005402 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272620005403 HipA-like C-terminal domain; Region: HipA_C; pfam07804 272620005404 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 272620005405 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 272620005406 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620005407 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620005408 PapC N-terminal domain; Region: PapC_N; pfam13954 272620005409 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620005410 PapC C-terminal domain; Region: PapC_C; pfam13953 272620005411 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620005412 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620005413 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620005414 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620005415 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272620005416 active site 272620005417 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 272620005418 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272620005419 PAS domain; Region: PAS_9; pfam13426 272620005420 putative active site [active] 272620005421 heme pocket [chemical binding]; other site 272620005422 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620005423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620005424 metal binding site [ion binding]; metal-binding site 272620005425 active site 272620005426 I-site; other site 272620005427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620005428 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272620005429 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620005430 active site 272620005431 phosphorylation site [posttranslational modification] 272620005432 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272620005433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005434 putative substrate translocation pore; other site 272620005435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005436 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272620005437 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 272620005438 NAD binding site [chemical binding]; other site 272620005439 sugar binding site [chemical binding]; other site 272620005440 divalent metal binding site [ion binding]; other site 272620005441 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620005442 dimer interface [polypeptide binding]; other site 272620005443 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 272620005444 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620005445 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620005446 active site turn [active] 272620005447 phosphorylation site [posttranslational modification] 272620005448 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272620005449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620005450 DNA-binding site [nucleotide binding]; DNA binding site 272620005451 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272620005452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005454 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 272620005455 putative dimerization interface [polypeptide binding]; other site 272620005456 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272620005457 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272620005458 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 272620005459 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 272620005460 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 272620005461 glycerate kinase; Region: TIGR00045 272620005462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005463 putative substrate translocation pore; other site 272620005464 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620005465 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272620005466 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 272620005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005468 putative substrate translocation pore; other site 272620005469 putative acyltransferase; Provisional; Region: PRK05790 272620005470 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620005471 dimer interface [polypeptide binding]; other site 272620005472 active site 272620005473 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272620005474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620005475 NAD(P) binding site [chemical binding]; other site 272620005476 active site 272620005477 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 272620005478 Coenzyme A transferase; Region: CoA_trans; smart00882 272620005479 Coenzyme A transferase; Region: CoA_trans; cl17247 272620005480 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 272620005481 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272620005482 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 272620005483 acyl-activating enzyme (AAE) consensus motif; other site 272620005484 acyl-activating enzyme (AAE) consensus motif; other site 272620005485 putative AMP binding site [chemical binding]; other site 272620005486 putative active site [active] 272620005487 putative CoA binding site [chemical binding]; other site 272620005488 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620005489 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272620005490 active site 272620005491 metal binding site [ion binding]; metal-binding site 272620005492 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 272620005493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005494 putative substrate translocation pore; other site 272620005495 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272620005496 dimer interface [polypeptide binding]; other site 272620005497 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620005498 substrate binding site [chemical binding]; other site 272620005499 ATP binding site [chemical binding]; other site 272620005500 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272620005501 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 272620005502 hexamer interface [polypeptide binding]; other site 272620005503 metal binding site [ion binding]; metal-binding site 272620005504 substrate binding site [chemical binding]; other site 272620005505 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620005506 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620005507 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620005508 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272620005509 intersubunit interface [polypeptide binding]; other site 272620005510 active site 272620005511 catalytic residue [active] 272620005512 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 272620005513 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 272620005514 putative N- and C-terminal domain interface [polypeptide binding]; other site 272620005515 putative active site [active] 272620005516 putative MgATP binding site [chemical binding]; other site 272620005517 catalytic site [active] 272620005518 metal binding site [ion binding]; metal-binding site 272620005519 putative xylulose binding site [chemical binding]; other site 272620005520 putative homodimer interface [polypeptide binding]; other site 272620005521 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620005522 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620005523 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620005524 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272620005525 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620005526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005528 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 272620005529 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; pfam10012 272620005530 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 272620005531 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 272620005532 conserved cys residue [active] 272620005533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005535 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272620005536 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272620005537 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272620005538 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620005539 Winged helix-turn helix; Region: HTH_29; pfam13551 272620005540 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620005541 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620005542 active site 272620005543 catalytic tetrad [active] 272620005544 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620005545 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620005546 active site 272620005547 catalytic tetrad [active] 272620005548 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005550 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 272620005551 putative effector binding pocket; other site 272620005552 putative dimerization interface [polypeptide binding]; other site 272620005553 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 272620005554 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272620005555 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620005556 active site 272620005557 phosphorylation site [posttranslational modification] 272620005558 intermolecular recognition site; other site 272620005559 dimerization interface [polypeptide binding]; other site 272620005560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272620005561 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620005562 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 272620005563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272620005564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620005565 dimer interface [polypeptide binding]; other site 272620005566 phosphorylation site [posttranslational modification] 272620005567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620005568 ATP binding site [chemical binding]; other site 272620005569 Mg2+ binding site [ion binding]; other site 272620005570 G-X-G motif; other site 272620005571 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272620005572 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272620005573 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 272620005574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005576 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 272620005577 BON domain; Region: BON; pfam04972 272620005578 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620005579 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 272620005580 BtpA family; Region: BtpA; cl00440 272620005581 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620005582 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 272620005583 substrate binding site [chemical binding]; other site 272620005584 ATP binding site [chemical binding]; other site 272620005585 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620005586 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 272620005587 ligand binding site [chemical binding]; other site 272620005588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620005589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620005590 DNA binding site [nucleotide binding] 272620005591 domain linker motif; other site 272620005592 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 272620005593 putative dimerization interface [polypeptide binding]; other site 272620005594 putative ligand binding site [chemical binding]; other site 272620005595 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 272620005596 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620005597 Walker A/P-loop; other site 272620005598 ATP binding site [chemical binding]; other site 272620005599 Q-loop/lid; other site 272620005600 ABC transporter signature motif; other site 272620005601 Walker B; other site 272620005602 D-loop; other site 272620005603 H-loop/switch region; other site 272620005604 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620005605 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620005606 TM-ABC transporter signature motif; other site 272620005607 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 272620005608 active site 272620005609 substrate binding pocket [chemical binding]; other site 272620005610 homodimer interaction site [polypeptide binding]; other site 272620005611 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 272620005612 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 272620005613 metal binding site [ion binding]; metal-binding site 272620005614 dimer interface [polypeptide binding]; other site 272620005615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272620005616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005618 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620005619 putative effector binding pocket; other site 272620005620 dimerization interface [polypeptide binding]; other site 272620005621 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005622 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005623 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620005624 putative effector binding pocket; other site 272620005625 dimerization interface [polypeptide binding]; other site 272620005626 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620005627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005628 putative substrate translocation pore; other site 272620005629 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272620005630 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272620005631 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272620005632 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272620005633 active site 272620005634 P-loop; other site 272620005635 phosphorylation site [posttranslational modification] 272620005636 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620005637 active site 272620005638 phosphorylation site [posttranslational modification] 272620005639 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272620005640 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272620005641 hexamer interface [polypeptide binding]; other site 272620005642 metal binding site [ion binding]; metal-binding site 272620005643 substrate binding site [chemical binding]; other site 272620005644 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272620005645 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272620005646 active site 272620005647 P-loop; other site 272620005648 phosphorylation site [posttranslational modification] 272620005649 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620005650 active site 272620005651 phosphorylation site [posttranslational modification] 272620005652 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620005653 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620005654 DNA binding site [nucleotide binding] 272620005655 domain linker motif; other site 272620005656 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 272620005657 putative dimerization interface [polypeptide binding]; other site 272620005658 putative ligand binding site [chemical binding]; other site 272620005659 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 272620005660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005661 putative substrate translocation pore; other site 272620005662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272620005663 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620005664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620005665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620005666 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272620005667 EamA-like transporter family; Region: EamA; pfam00892 272620005668 EamA-like transporter family; Region: EamA; pfam00892 272620005669 putative sialic acid transporter; Region: 2A0112; TIGR00891 272620005670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005671 putative substrate translocation pore; other site 272620005672 hypothetical protein; Provisional; Region: PRK09897 272620005673 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 272620005674 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272620005675 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272620005676 active site 272620005677 FMN binding site [chemical binding]; other site 272620005678 substrate binding site [chemical binding]; other site 272620005679 homotetramer interface [polypeptide binding]; other site 272620005680 catalytic residue [active] 272620005681 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005682 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005683 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620005684 putative effector binding pocket; other site 272620005685 putative dimerization interface [polypeptide binding]; other site 272620005686 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 272620005687 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 272620005688 FMN binding site [chemical binding]; other site 272620005689 substrate binding site [chemical binding]; other site 272620005690 putative catalytic residue [active] 272620005691 allantoate amidohydrolase; Reviewed; Region: PRK09290 272620005692 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 272620005693 active site 272620005694 metal binding site [ion binding]; metal-binding site 272620005695 dimer interface [polypeptide binding]; other site 272620005696 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272620005697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620005698 catalytic residue [active] 272620005699 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620005700 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620005701 Walker A/P-loop; other site 272620005702 ATP binding site [chemical binding]; other site 272620005703 Q-loop/lid; other site 272620005704 ABC transporter signature motif; other site 272620005705 Walker B; other site 272620005706 D-loop; other site 272620005707 H-loop/switch region; other site 272620005708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620005709 dimer interface [polypeptide binding]; other site 272620005710 conserved gate region; other site 272620005711 putative PBP binding loops; other site 272620005712 ABC-ATPase subunit interface; other site 272620005713 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620005714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620005715 dimer interface [polypeptide binding]; other site 272620005716 conserved gate region; other site 272620005717 putative PBP binding loops; other site 272620005718 ABC-ATPase subunit interface; other site 272620005719 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620005720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620005721 substrate binding pocket [chemical binding]; other site 272620005722 membrane-bound complex binding site; other site 272620005723 hinge residues; other site 272620005724 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620005725 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620005726 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272620005727 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 272620005728 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 272620005729 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 272620005730 amidase; Provisional; Region: PRK09201 272620005731 Amidase; Region: Amidase; pfam01425 272620005732 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 272620005733 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620005734 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620005735 Coenzyme A binding pocket [chemical binding]; other site 272620005736 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 272620005737 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272620005738 Predicted transcriptional regulators [Transcription]; Region: COG1733 272620005739 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272620005740 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 272620005741 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620005742 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620005743 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272620005744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005745 putative substrate translocation pore; other site 272620005746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005747 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 272620005748 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272620005749 dimer interface [polypeptide binding]; other site 272620005750 active site 272620005751 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 272620005752 Transposase domain (DUF772); Region: DUF772; pfam05598 272620005753 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 272620005754 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272620005755 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620005756 Helix-turn-helix domain; Region: HTH_18; pfam12833 272620005757 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272620005758 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272620005759 catalytic triad [active] 272620005760 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272620005761 classical (c) SDRs; Region: SDR_c; cd05233 272620005762 NAD(P) binding site [chemical binding]; other site 272620005763 active site 272620005764 Isochorismatase family; Region: Isochorismatase; pfam00857 272620005765 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272620005766 catalytic triad [active] 272620005767 conserved cis-peptide bond; other site 272620005768 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272620005769 catalytic core [active] 272620005770 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620005771 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620005772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620005774 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272620005775 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 272620005776 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 272620005777 active site 272620005778 catalytic site [active] 272620005779 tetramer interface [polypeptide binding]; other site 272620005780 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 272620005781 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272620005782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620005783 DNA-binding site [nucleotide binding]; DNA binding site 272620005784 FCD domain; Region: FCD; pfam07729 272620005785 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 272620005786 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 272620005787 Na binding site [ion binding]; other site 272620005788 putative substrate binding site [chemical binding]; other site 272620005789 guanine deaminase; Provisional; Region: PRK09228 272620005790 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 272620005791 active site 272620005792 Protein of unknown function (DUF2931); Region: DUF2931; pfam11153 272620005793 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 272620005794 PAS domain S-box; Region: sensory_box; TIGR00229 272620005795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272620005796 putative active site [active] 272620005797 heme pocket [chemical binding]; other site 272620005798 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620005799 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620005800 metal binding site [ion binding]; metal-binding site 272620005801 active site 272620005802 I-site; other site 272620005803 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620005804 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620005805 DNA binding site [nucleotide binding] 272620005806 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272620005807 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272620005808 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272620005809 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620005810 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620005811 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620005812 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 272620005813 Putative transcription activator [Transcription]; Region: TenA; COG0819 272620005814 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272620005815 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620005816 Walker A/P-loop; other site 272620005817 ATP binding site [chemical binding]; other site 272620005818 Q-loop/lid; other site 272620005819 ABC transporter signature motif; other site 272620005820 Walker B; other site 272620005821 D-loop; other site 272620005822 H-loop/switch region; other site 272620005823 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272620005824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620005825 dimer interface [polypeptide binding]; other site 272620005826 conserved gate region; other site 272620005827 ABC-ATPase subunit interface; other site 272620005828 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 272620005829 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620005830 inhibitor-cofactor binding pocket; inhibition site 272620005831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620005832 catalytic residue [active] 272620005833 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 272620005834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620005835 catalytic residue [active] 272620005836 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005837 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005838 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620005839 dimerization interface [polypeptide binding]; other site 272620005840 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 272620005841 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272620005842 catalytic residues [active] 272620005843 HAMP domain; Region: HAMP; pfam00672 272620005844 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620005845 dimer interface [polypeptide binding]; other site 272620005846 phosphorylation site [posttranslational modification] 272620005847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620005848 ATP binding site [chemical binding]; other site 272620005849 Mg2+ binding site [ion binding]; other site 272620005850 G-X-G motif; other site 272620005851 osmolarity response regulator; Provisional; Region: ompR; PRK09468 272620005852 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620005853 active site 272620005854 phosphorylation site [posttranslational modification] 272620005855 intermolecular recognition site; other site 272620005856 dimerization interface [polypeptide binding]; other site 272620005857 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620005858 DNA binding site [nucleotide binding] 272620005859 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272620005860 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 272620005861 active site 272620005862 dimer interface [polypeptide binding]; other site 272620005863 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 272620005864 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 272620005865 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 272620005866 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 272620005867 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 272620005868 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620005869 FeS/SAM binding site; other site 272620005870 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272620005871 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 272620005872 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272620005873 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 272620005874 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 272620005875 catalytic triad [active] 272620005876 penicillin-binding protein 2; Provisional; Region: PRK10795 272620005877 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272620005878 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272620005879 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272620005880 Protein of unknown function, DUF606; Region: DUF606; pfam04657 272620005881 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005882 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005883 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620005884 putative effector binding pocket; other site 272620005885 dimerization interface [polypeptide binding]; other site 272620005886 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 272620005887 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 272620005888 heme binding site [chemical binding]; other site 272620005889 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 272620005890 heme binding site [chemical binding]; other site 272620005891 Predicted ATPase [General function prediction only]; Region: COG1485 272620005892 magnesium transport protein MgtC; Provisional; Region: PRK15385 272620005893 MgtC family; Region: MgtC; pfam02308 272620005894 benzoate transport; Region: 2A0115; TIGR00895 272620005895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005896 putative substrate translocation pore; other site 272620005897 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620005898 putative substrate translocation pore; other site 272620005899 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272620005900 methionine cluster; other site 272620005901 active site 272620005902 phosphorylation site [posttranslational modification] 272620005903 metal binding site [ion binding]; metal-binding site 272620005904 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005906 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620005907 dimerization interface [polypeptide binding]; other site 272620005908 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 272620005909 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 272620005910 putative molybdopterin cofactor binding site [chemical binding]; other site 272620005911 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 272620005912 putative molybdopterin cofactor binding site; other site 272620005913 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 272620005914 Cation efflux family; Region: Cation_efflux; pfam01545 272620005915 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272620005916 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620005917 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620005918 substrate binding pocket [chemical binding]; other site 272620005919 membrane-bound complex binding site; other site 272620005920 hinge residues; other site 272620005921 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 272620005922 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 272620005923 hypothetical protein; Provisional; Region: PRK10053 272620005924 Predicted membrane protein [Function unknown]; Region: COG2323 272620005925 short chain dehydrogenase; Provisional; Region: PRK07109 272620005926 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 272620005927 putative NAD(P) binding site [chemical binding]; other site 272620005928 active site 272620005929 trehalose synthase; Region: treS_nterm; TIGR02456 272620005930 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 272620005931 active site 272620005932 catalytic site [active] 272620005933 Domain of unknown function (DUF892); Region: DUF892; pfam05974 272620005934 General stress protein [General function prediction only]; Region: GsiB; COG3729 272620005935 oxidoreductase; Provisional; Region: PRK06128 272620005936 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 272620005937 NAD binding site [chemical binding]; other site 272620005938 metal binding site [ion binding]; metal-binding site 272620005939 active site 272620005940 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 272620005941 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620005942 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620005943 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620005944 putative effector binding pocket; other site 272620005945 dimerization interface [polypeptide binding]; other site 272620005946 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272620005947 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 272620005948 malate dehydrogenase; Provisional; Region: PRK13529 272620005949 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272620005950 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 272620005951 NAD(P) binding site [chemical binding]; other site 272620005952 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620005953 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272620005954 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620005955 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620005956 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 272620005957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620005958 Coenzyme A binding pocket [chemical binding]; other site 272620005959 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272620005960 dimer interface [polypeptide binding]; other site 272620005961 substrate binding site [chemical binding]; other site 272620005962 metal binding sites [ion binding]; metal-binding site 272620005963 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 272620005964 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 272620005965 NAD binding site [chemical binding]; other site 272620005966 substrate binding site [chemical binding]; other site 272620005967 catalytic Zn binding site [ion binding]; other site 272620005968 tetramer interface [polypeptide binding]; other site 272620005969 structural Zn binding site [ion binding]; other site 272620005970 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620005971 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 272620005972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272620005973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620005974 dimer interface [polypeptide binding]; other site 272620005975 conserved gate region; other site 272620005976 ABC-ATPase subunit interface; other site 272620005977 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272620005978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620005979 ABC-ATPase subunit interface; other site 272620005980 putative PBP binding loops; other site 272620005981 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272620005982 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620005983 Walker A/P-loop; other site 272620005984 ATP binding site [chemical binding]; other site 272620005985 Q-loop/lid; other site 272620005986 ABC transporter signature motif; other site 272620005987 Walker B; other site 272620005988 D-loop; other site 272620005989 H-loop/switch region; other site 272620005990 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620005991 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620005992 Walker A/P-loop; other site 272620005993 ATP binding site [chemical binding]; other site 272620005994 Q-loop/lid; other site 272620005995 ABC transporter signature motif; other site 272620005996 Walker B; other site 272620005997 D-loop; other site 272620005998 H-loop/switch region; other site 272620005999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620006000 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 272620006001 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 272620006002 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 272620006003 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 272620006004 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 272620006005 MFS transport protein AraJ; Provisional; Region: PRK10091 272620006006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006007 putative substrate translocation pore; other site 272620006008 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620006009 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 272620006010 active site 272620006011 metal binding site [ion binding]; metal-binding site 272620006012 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 272620006013 Exocyst complex component Sec10; Region: Sec10; pfam07393 272620006014 CcdB protein; Region: CcdB; cl03380 272620006015 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 272620006016 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 272620006017 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 272620006018 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 272620006019 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620006020 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620006021 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620006022 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 272620006023 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 272620006024 molybdopterin cofactor binding site; other site 272620006025 aromatic amino acid exporter; Provisional; Region: PRK11689 272620006026 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 272620006027 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 272620006028 putative NAD(P) binding site [chemical binding]; other site 272620006029 active site 272620006030 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 272620006031 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620006032 catalytic loop [active] 272620006033 iron binding site [ion binding]; other site 272620006034 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 272620006035 FAD binding pocket [chemical binding]; other site 272620006036 FAD binding motif [chemical binding]; other site 272620006037 phosphate binding motif [ion binding]; other site 272620006038 beta-alpha-beta structure motif; other site 272620006039 NAD binding pocket [chemical binding]; other site 272620006040 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 272620006041 inter-subunit interface; other site 272620006042 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 272620006043 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 272620006044 iron-sulfur cluster [ion binding]; other site 272620006045 [2Fe-2S] cluster binding site [ion binding]; other site 272620006046 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 272620006047 putative alpha subunit interface [polypeptide binding]; other site 272620006048 putative active site [active] 272620006049 putative substrate binding site [chemical binding]; other site 272620006050 Fe binding site [ion binding]; other site 272620006051 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 272620006052 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 272620006053 dimer interface [polypeptide binding]; other site 272620006054 active site 272620006055 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 272620006056 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 272620006057 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 272620006058 octamer interface [polypeptide binding]; other site 272620006059 active site 272620006060 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 272620006061 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620006062 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620006063 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 272620006064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006065 putative substrate translocation pore; other site 272620006066 TetR family transcriptional regulator; Provisional; Region: PRK14996 272620006067 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620006068 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 272620006069 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 272620006070 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 272620006071 [4Fe-4S] binding site [ion binding]; other site 272620006072 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620006073 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620006074 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620006075 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 272620006076 molybdopterin cofactor binding site; other site 272620006077 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 272620006078 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 272620006079 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 272620006080 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 272620006081 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272620006082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006083 dimer interface [polypeptide binding]; other site 272620006084 conserved gate region; other site 272620006085 putative PBP binding loops; other site 272620006086 ABC-ATPase subunit interface; other site 272620006087 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272620006088 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272620006089 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 272620006090 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272620006091 Walker A/P-loop; other site 272620006092 ATP binding site [chemical binding]; other site 272620006093 Q-loop/lid; other site 272620006094 ABC transporter signature motif; other site 272620006095 Walker B; other site 272620006096 D-loop; other site 272620006097 H-loop/switch region; other site 272620006098 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 272620006099 transcriptional activator RhaR; Provisional; Region: PRK13501 272620006100 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620006101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620006102 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 272620006103 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620006104 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 272620006105 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 272620006106 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 272620006107 trimer interface; other site 272620006108 sugar binding site [chemical binding]; other site 272620006109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620006110 non-specific DNA binding site [nucleotide binding]; other site 272620006111 salt bridge; other site 272620006112 sequence-specific DNA binding site [nucleotide binding]; other site 272620006113 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 272620006114 active site 1 [active] 272620006115 dimer interface [polypeptide binding]; other site 272620006116 hexamer interface [polypeptide binding]; other site 272620006117 active site 2 [active] 272620006118 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 272620006119 C-terminal domain interface [polypeptide binding]; other site 272620006120 GSH binding site (G-site) [chemical binding]; other site 272620006121 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272620006122 dimer interface [polypeptide binding]; other site 272620006123 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 272620006124 dimer interface [polypeptide binding]; other site 272620006125 N-terminal domain interface [polypeptide binding]; other site 272620006126 substrate binding pocket (H-site) [chemical binding]; other site 272620006127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620006128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620006129 substrate binding pocket [chemical binding]; other site 272620006130 membrane-bound complex binding site; other site 272620006131 hinge residues; other site 272620006132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620006133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620006134 Walker A/P-loop; other site 272620006135 ATP binding site [chemical binding]; other site 272620006136 Q-loop/lid; other site 272620006137 ABC transporter signature motif; other site 272620006138 Walker B; other site 272620006139 D-loop; other site 272620006140 H-loop/switch region; other site 272620006141 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620006142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006143 dimer interface [polypeptide binding]; other site 272620006144 conserved gate region; other site 272620006145 putative PBP binding loops; other site 272620006146 ABC-ATPase subunit interface; other site 272620006147 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620006148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620006149 Coenzyme A binding pocket [chemical binding]; other site 272620006150 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620006151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620006152 substrate binding pocket [chemical binding]; other site 272620006153 membrane-bound complex binding site; other site 272620006154 hinge residues; other site 272620006155 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272620006156 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 272620006157 metal binding site [ion binding]; metal-binding site 272620006158 dimer interface [polypeptide binding]; other site 272620006159 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 272620006160 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272620006161 AAA domain; Region: AAA_17; pfam13207 272620006162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620006163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006164 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 272620006165 putative effector binding pocket; other site 272620006166 putative dimerization interface [polypeptide binding]; other site 272620006167 L-asparagine permease; Provisional; Region: PRK15049 272620006168 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 272620006169 Uncharacterized conserved protein [Function unknown]; Region: COG3391 272620006170 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 272620006171 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 272620006172 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620006173 N-terminal plug; other site 272620006174 ligand-binding site [chemical binding]; other site 272620006175 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 272620006176 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 272620006177 active site 272620006178 hypothetical protein; Provisional; Region: PRK09981 272620006179 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 272620006180 active site 272620006181 tetramer interface [polypeptide binding]; other site 272620006182 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 272620006183 Prostaglandin dehydrogenases; Region: PGDH; cd05288 272620006184 NAD(P) binding site [chemical binding]; other site 272620006185 substrate binding site [chemical binding]; other site 272620006186 dimer interface [polypeptide binding]; other site 272620006187 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620006188 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620006189 sequence-specific DNA binding site [nucleotide binding]; other site 272620006190 salt bridge; other site 272620006191 Cupin domain; Region: Cupin_2; pfam07883 272620006192 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272620006193 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620006194 Coenzyme A binding pocket [chemical binding]; other site 272620006195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 272620006196 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 272620006197 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620006198 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 272620006199 peptide binding site [polypeptide binding]; other site 272620006200 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272620006201 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 272620006202 NAD(P) binding site [chemical binding]; other site 272620006203 catalytic residues [active] 272620006204 PGAP1-like protein; Region: PGAP1; pfam07819 272620006205 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272620006206 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 272620006207 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 272620006208 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 272620006209 tetrameric interface [polypeptide binding]; other site 272620006210 NAD binding site [chemical binding]; other site 272620006211 catalytic residues [active] 272620006212 substrate binding site [chemical binding]; other site 272620006213 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272620006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272620006215 putative PBP binding loops; other site 272620006216 dimer interface [polypeptide binding]; other site 272620006217 ABC-ATPase subunit interface; other site 272620006218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006219 dimer interface [polypeptide binding]; other site 272620006220 conserved gate region; other site 272620006221 putative PBP binding loops; other site 272620006222 ABC-ATPase subunit interface; other site 272620006223 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272620006224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620006225 Walker A/P-loop; other site 272620006226 ATP binding site [chemical binding]; other site 272620006227 Q-loop/lid; other site 272620006228 ABC transporter signature motif; other site 272620006229 Walker B; other site 272620006230 D-loop; other site 272620006231 H-loop/switch region; other site 272620006232 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272620006233 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272620006234 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620006235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620006236 DNA-binding site [nucleotide binding]; DNA binding site 272620006237 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620006238 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620006239 homodimer interface [polypeptide binding]; other site 272620006240 catalytic residue [active] 272620006241 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 272620006242 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 272620006243 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272620006244 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 272620006245 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 272620006246 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272620006247 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272620006248 Peptidase family U32; Region: Peptidase_U32; pfam01136 272620006249 Collagenase; Region: DUF3656; pfam12392 272620006250 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620006251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620006252 non-specific DNA binding site [nucleotide binding]; other site 272620006253 salt bridge; other site 272620006254 sequence-specific DNA binding site [nucleotide binding]; other site 272620006255 Cupin domain; Region: Cupin_2; pfam07883 272620006256 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 272620006257 benzoate transporter; Region: benE; TIGR00843 272620006258 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620006259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620006260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620006261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272620006262 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 272620006263 tellurite resistance protein TehB; Provisional; Region: PRK11207 272620006264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620006265 S-adenosylmethionine binding site [chemical binding]; other site 272620006266 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 272620006267 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 272620006268 gating phenylalanine in ion channel; other site 272620006269 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 272620006270 putative trimer interface [polypeptide binding]; other site 272620006271 putative CoA binding site [chemical binding]; other site 272620006272 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272620006273 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620006274 Coenzyme A binding pocket [chemical binding]; other site 272620006275 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 272620006276 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 272620006277 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 272620006278 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 272620006279 catalytic Zn binding site [ion binding]; other site 272620006280 NAD binding site [chemical binding]; other site 272620006281 structural Zn binding site [ion binding]; other site 272620006282 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 272620006283 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272620006284 substrate binding pocket [chemical binding]; other site 272620006285 catalytic triad [active] 272620006286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 272620006287 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 272620006288 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 272620006289 heterodimer interface [polypeptide binding]; other site 272620006290 multimer interface [polypeptide binding]; other site 272620006291 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 272620006292 active site 272620006293 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 272620006294 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 272620006295 heterodimer interface [polypeptide binding]; other site 272620006296 active site 272620006297 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 272620006298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006299 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 272620006300 putative dimerization interface [polypeptide binding]; other site 272620006301 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 272620006302 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 272620006303 Trp docking motif [polypeptide binding]; other site 272620006304 putative active site [active] 272620006305 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 272620006306 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 272620006307 substrate binding site [chemical binding]; other site 272620006308 catalytic Zn binding site [ion binding]; other site 272620006309 NAD binding site [chemical binding]; other site 272620006310 structural Zn binding site [ion binding]; other site 272620006311 dimer interface [polypeptide binding]; other site 272620006312 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 272620006313 putative metal binding site [ion binding]; other site 272620006314 putative homodimer interface [polypeptide binding]; other site 272620006315 putative homotetramer interface [polypeptide binding]; other site 272620006316 putative homodimer-homodimer interface [polypeptide binding]; other site 272620006317 putative allosteric switch controlling residues; other site 272620006318 cytochrome b561; Provisional; Region: PRK11513 272620006319 Predicted transcriptional regulators [Transcription]; Region: COG1733 272620006320 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272620006321 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620006322 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 272620006323 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 272620006324 active site 272620006325 purine riboside binding site [chemical binding]; other site 272620006326 putative oxidoreductase; Provisional; Region: PRK11579 272620006327 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620006328 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620006329 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272620006330 beta-galactosidase; Region: BGL; TIGR03356 272620006331 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 272620006332 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 272620006333 electron transport complex protein RsxA; Provisional; Region: PRK05151 272620006334 electron transport complex protein RnfB; Provisional; Region: PRK05113 272620006335 Putative Fe-S cluster; Region: FeS; cl17515 272620006336 4Fe-4S binding domain; Region: Fer4; cl02805 272620006337 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 272620006338 SLBB domain; Region: SLBB; pfam10531 272620006339 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272620006340 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 272620006341 electron transport complex protein RnfG; Validated; Region: PRK01908 272620006342 electron transport complex RsxE subunit; Provisional; Region: PRK12405 272620006343 endonuclease III; Provisional; Region: PRK10702 272620006344 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272620006345 minor groove reading motif; other site 272620006346 helix-hairpin-helix signature motif; other site 272620006347 substrate binding pocket [chemical binding]; other site 272620006348 active site 272620006349 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272620006350 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 272620006351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006352 putative substrate translocation pore; other site 272620006353 POT family; Region: PTR2; pfam00854 272620006354 glutathionine S-transferase; Provisional; Region: PRK10542 272620006355 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 272620006356 C-terminal domain interface [polypeptide binding]; other site 272620006357 GSH binding site (G-site) [chemical binding]; other site 272620006358 dimer interface [polypeptide binding]; other site 272620006359 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 272620006360 N-terminal domain interface [polypeptide binding]; other site 272620006361 dimer interface [polypeptide binding]; other site 272620006362 substrate binding pocket (H-site) [chemical binding]; other site 272620006363 pyridoxamine kinase; Validated; Region: PRK05756 272620006364 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 272620006365 dimer interface [polypeptide binding]; other site 272620006366 pyridoxal binding site [chemical binding]; other site 272620006367 ATP binding site [chemical binding]; other site 272620006368 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272620006369 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272620006370 active site 272620006371 HIGH motif; other site 272620006372 dimer interface [polypeptide binding]; other site 272620006373 KMSKS motif; other site 272620006374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620006375 RNA binding surface [nucleotide binding]; other site 272620006376 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 272620006377 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 272620006378 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 272620006379 lysozyme inhibitor; Provisional; Region: PRK11372 272620006380 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 272620006381 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 272620006382 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 272620006383 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620006384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620006385 metal binding site [ion binding]; metal-binding site 272620006386 active site 272620006387 I-site; other site 272620006388 transcriptional regulator SlyA; Provisional; Region: PRK03573 272620006389 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 272620006390 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 272620006391 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 272620006392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620006393 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620006394 Fusaric acid resistance protein family; Region: FUSC; pfam04632 272620006395 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272620006396 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 272620006397 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 272620006398 E-class dimer interface [polypeptide binding]; other site 272620006399 P-class dimer interface [polypeptide binding]; other site 272620006400 active site 272620006401 Cu2+ binding site [ion binding]; other site 272620006402 Zn2+ binding site [ion binding]; other site 272620006403 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620006404 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620006405 active site 272620006406 catalytic tetrad [active] 272620006407 Predicted Fe-S protein [General function prediction only]; Region: COG3313 272620006408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620006409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620006410 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272620006411 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 272620006412 FMN binding site [chemical binding]; other site 272620006413 active site 272620006414 substrate binding site [chemical binding]; other site 272620006415 catalytic residue [active] 272620006416 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620006417 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 272620006418 dimer interface [polypeptide binding]; other site 272620006419 active site 272620006420 metal binding site [ion binding]; metal-binding site 272620006421 glutathione binding site [chemical binding]; other site 272620006422 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 272620006423 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 272620006424 dimer interface [polypeptide binding]; other site 272620006425 catalytic site [active] 272620006426 putative active site [active] 272620006427 putative substrate binding site [chemical binding]; other site 272620006428 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 272620006429 putative GSH binding site [chemical binding]; other site 272620006430 catalytic residues [active] 272620006431 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 272620006432 NlpC/P60 family; Region: NLPC_P60; pfam00877 272620006433 superoxide dismutase; Provisional; Region: PRK10543 272620006434 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272620006435 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272620006436 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 272620006437 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006438 putative substrate translocation pore; other site 272620006439 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 272620006440 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620006441 DNA binding site [nucleotide binding] 272620006442 domain linker motif; other site 272620006443 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 272620006444 dimerization interface [polypeptide binding]; other site 272620006445 ligand binding site [chemical binding]; other site 272620006446 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 272620006447 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006448 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620006449 dimerization interface [polypeptide binding]; other site 272620006450 putative transporter; Provisional; Region: PRK11043 272620006451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006452 putative substrate translocation pore; other site 272620006453 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 272620006454 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620006455 S-adenosylmethionine binding site [chemical binding]; other site 272620006456 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 272620006457 Lumazine binding domain; Region: Lum_binding; pfam00677 272620006458 Lumazine binding domain; Region: Lum_binding; pfam00677 272620006459 multidrug efflux protein; Reviewed; Region: PRK01766 272620006460 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 272620006461 cation binding site [ion binding]; other site 272620006462 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 272620006463 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 272620006464 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272620006465 NADP binding site [chemical binding]; other site 272620006466 active site 272620006467 steroid binding site; other site 272620006468 Cupin; Region: Cupin_6; pfam12852 272620006469 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620006470 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620006471 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 272620006472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620006474 dimerization interface [polypeptide binding]; other site 272620006475 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 272620006476 active site clefts [active] 272620006477 zinc binding site [ion binding]; other site 272620006478 dimer interface [polypeptide binding]; other site 272620006479 LysE type translocator; Region: LysE; cl00565 272620006480 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620006481 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620006482 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620006483 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 272620006484 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620006485 putative metal binding site [ion binding]; other site 272620006486 Chloramphenicol acetyltransferase; Region: CAT; cl02008 272620006487 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620006488 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 272620006489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272620006490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006491 dimer interface [polypeptide binding]; other site 272620006492 conserved gate region; other site 272620006493 putative PBP binding loops; other site 272620006494 ABC-ATPase subunit interface; other site 272620006495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272620006496 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620006497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006498 dimer interface [polypeptide binding]; other site 272620006499 conserved gate region; other site 272620006500 putative PBP binding loops; other site 272620006501 ABC-ATPase subunit interface; other site 272620006502 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272620006503 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620006504 Walker A/P-loop; other site 272620006505 ATP binding site [chemical binding]; other site 272620006506 Q-loop/lid; other site 272620006507 ABC transporter signature motif; other site 272620006508 Walker B; other site 272620006509 D-loop; other site 272620006510 H-loop/switch region; other site 272620006511 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620006512 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 272620006513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620006514 Walker A/P-loop; other site 272620006515 ATP binding site [chemical binding]; other site 272620006516 Q-loop/lid; other site 272620006517 ABC transporter signature motif; other site 272620006518 Walker B; other site 272620006519 D-loop; other site 272620006520 H-loop/switch region; other site 272620006521 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272620006522 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 272620006523 DinB family; Region: DinB; cl17821 272620006524 DinB superfamily; Region: DinB_2; pfam12867 272620006525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006526 putative substrate translocation pore; other site 272620006527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620006528 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620006529 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006530 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 272620006531 putative effector binding pocket; other site 272620006532 putative dimerization interface [polypeptide binding]; other site 272620006533 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 272620006534 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 272620006535 putative NAD(P) binding site [chemical binding]; other site 272620006536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006537 transcriptional regulator; Provisional; Region: PRK10632 272620006538 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620006539 putative effector binding pocket; other site 272620006540 putative dimerization interface [polypeptide binding]; other site 272620006541 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 272620006542 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 272620006543 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 272620006544 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 272620006545 amidohydrolase; Provisional; Region: PRK12393 272620006546 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 272620006547 active site 272620006548 putative substrate binding pocket [chemical binding]; other site 272620006549 NMT1/THI5 like; Region: NMT1; pfam09084 272620006550 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620006552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620006553 dimerization interface [polypeptide binding]; other site 272620006554 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 272620006555 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 272620006556 FMN-binding pocket [chemical binding]; other site 272620006557 flavin binding motif; other site 272620006558 phosphate binding motif [ion binding]; other site 272620006559 beta-alpha-beta structure motif; other site 272620006560 NAD binding pocket [chemical binding]; other site 272620006561 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620006562 catalytic loop [active] 272620006563 iron binding site [ion binding]; other site 272620006564 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272620006565 Amidohydrolase; Region: Amidohydro_4; pfam13147 272620006566 active site 272620006567 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272620006568 homotrimer interaction site [polypeptide binding]; other site 272620006569 putative active site [active] 272620006570 Creatinine amidohydrolase; Region: Creatininase; pfam02633 272620006571 NMT1/THI5 like; Region: NMT1; pfam09084 272620006572 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272620006573 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272620006574 Walker A/P-loop; other site 272620006575 ATP binding site [chemical binding]; other site 272620006576 Q-loop/lid; other site 272620006577 ABC transporter signature motif; other site 272620006578 Walker B; other site 272620006579 D-loop; other site 272620006580 H-loop/switch region; other site 272620006581 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272620006582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006583 dimer interface [polypeptide binding]; other site 272620006584 conserved gate region; other site 272620006585 putative PBP binding loops; other site 272620006586 ABC-ATPase subunit interface; other site 272620006587 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272620006588 FAD binding domain; Region: FAD_binding_4; pfam01565 272620006589 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 272620006590 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 272620006591 Chromate transporter; Region: Chromate_transp; pfam02417 272620006592 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 272620006593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006594 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620006595 putative substrate translocation pore; other site 272620006596 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272620006597 active site 1 [active] 272620006598 dimer interface [polypeptide binding]; other site 272620006599 hexamer interface [polypeptide binding]; other site 272620006600 active site 2 [active] 272620006601 Protein of unknown function (DUF535); Region: DUF535; cl01128 272620006602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620006603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006604 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 272620006605 putative dimerization interface [polypeptide binding]; other site 272620006606 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 272620006607 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 272620006608 putative acyltransferase; Provisional; Region: PRK05790 272620006609 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620006610 dimer interface [polypeptide binding]; other site 272620006611 active site 272620006612 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 272620006613 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272620006614 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620006615 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 272620006616 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 272620006617 NAD binding site [chemical binding]; other site 272620006618 homotetramer interface [polypeptide binding]; other site 272620006619 homodimer interface [polypeptide binding]; other site 272620006620 substrate binding site [chemical binding]; other site 272620006621 active site 272620006622 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 272620006623 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006624 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 272620006625 putative dimerization interface [polypeptide binding]; other site 272620006626 putative substrate binding pocket [chemical binding]; other site 272620006627 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 272620006628 acetolactate synthase; Reviewed; Region: PRK08617 272620006629 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620006630 PYR/PP interface [polypeptide binding]; other site 272620006631 dimer interface [polypeptide binding]; other site 272620006632 TPP binding site [chemical binding]; other site 272620006633 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620006634 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 272620006635 TPP-binding site [chemical binding]; other site 272620006636 dimer interface [polypeptide binding]; other site 272620006637 acetoin reductase; Validated; Region: PRK08643 272620006638 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 272620006639 NAD binding site [chemical binding]; other site 272620006640 homotetramer interface [polypeptide binding]; other site 272620006641 homodimer interface [polypeptide binding]; other site 272620006642 active site 272620006643 substrate binding site [chemical binding]; other site 272620006644 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272620006645 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620006646 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272620006647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272620006648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620006649 active site 272620006650 phosphorylation site [posttranslational modification] 272620006651 intermolecular recognition site; other site 272620006652 dimerization interface [polypeptide binding]; other site 272620006653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620006654 DNA binding site [nucleotide binding] 272620006655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272620006656 HAMP domain; Region: HAMP; pfam00672 272620006657 dimerization interface [polypeptide binding]; other site 272620006658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620006659 dimer interface [polypeptide binding]; other site 272620006660 phosphorylation site [posttranslational modification] 272620006661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620006662 ATP binding site [chemical binding]; other site 272620006663 Mg2+ binding site [ion binding]; other site 272620006664 G-X-G motif; other site 272620006665 Transposase domain (DUF772); Region: DUF772; pfam05598 272620006666 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 272620006667 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272620006668 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 272620006669 putative dimer interface [polypeptide binding]; other site 272620006670 catalytic triad [active] 272620006671 Gram-negative bacterial tonB protein; Region: TonB; cl10048 272620006672 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620006673 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620006674 Coenzyme A binding pocket [chemical binding]; other site 272620006675 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 272620006676 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 272620006677 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 272620006678 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 272620006679 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272620006680 catalytic residues [active] 272620006681 central insert; other site 272620006682 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 272620006683 CcmE; Region: CcmE; cl00994 272620006684 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 272620006685 heme exporter protein CcmC; Region: ccmC; TIGR01191 272620006686 heme exporter protein CcmB; Region: ccmB; TIGR01190 272620006687 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 272620006688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620006689 Walker A/P-loop; other site 272620006690 ATP binding site [chemical binding]; other site 272620006691 Q-loop/lid; other site 272620006692 ABC transporter signature motif; other site 272620006693 Walker B; other site 272620006694 D-loop; other site 272620006695 H-loop/switch region; other site 272620006696 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272620006697 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 272620006698 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 272620006699 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 272620006700 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272620006701 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 272620006702 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 272620006703 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272620006704 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620006705 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272620006706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620006707 Walker A/P-loop; other site 272620006708 ATP binding site [chemical binding]; other site 272620006709 Q-loop/lid; other site 272620006710 ABC transporter signature motif; other site 272620006711 Walker B; other site 272620006712 D-loop; other site 272620006713 H-loop/switch region; other site 272620006714 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 272620006715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006716 dimer interface [polypeptide binding]; other site 272620006717 conserved gate region; other site 272620006718 ABC-ATPase subunit interface; other site 272620006719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006720 dimer interface [polypeptide binding]; other site 272620006721 conserved gate region; other site 272620006722 putative PBP binding loops; other site 272620006723 ABC-ATPase subunit interface; other site 272620006724 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272620006725 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272620006726 putative dehydrogenase; Provisional; Region: PRK10098 272620006727 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 272620006728 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 272620006729 [4Fe-4S] binding site [ion binding]; other site 272620006730 molybdopterin cofactor binding site; other site 272620006731 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 272620006732 molybdopterin cofactor binding site; other site 272620006733 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272620006734 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 272620006735 metal binding site [ion binding]; metal-binding site 272620006736 putative dimer interface [polypeptide binding]; other site 272620006737 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272620006738 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620006739 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 272620006740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006741 putative substrate translocation pore; other site 272620006742 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 272620006743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620006744 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 272620006745 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620006746 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620006747 Walker A/P-loop; other site 272620006748 ATP binding site [chemical binding]; other site 272620006749 Q-loop/lid; other site 272620006750 ABC transporter signature motif; other site 272620006751 Walker B; other site 272620006752 D-loop; other site 272620006753 H-loop/switch region; other site 272620006754 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620006755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006756 dimer interface [polypeptide binding]; other site 272620006757 conserved gate region; other site 272620006758 putative PBP binding loops; other site 272620006759 ABC-ATPase subunit interface; other site 272620006760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620006761 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620006762 substrate binding pocket [chemical binding]; other site 272620006763 membrane-bound complex binding site; other site 272620006764 hinge residues; other site 272620006765 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620006766 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620006767 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 272620006768 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 272620006769 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272620006770 siderophore binding site; other site 272620006771 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620006772 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620006773 ABC-ATPase subunit interface; other site 272620006774 dimer interface [polypeptide binding]; other site 272620006775 putative PBP binding regions; other site 272620006776 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620006777 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620006778 ABC-ATPase subunit interface; other site 272620006779 dimer interface [polypeptide binding]; other site 272620006780 putative PBP binding regions; other site 272620006781 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272620006782 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620006783 Walker A/P-loop; other site 272620006784 ATP binding site [chemical binding]; other site 272620006785 Q-loop/lid; other site 272620006786 ABC transporter signature motif; other site 272620006787 Walker B; other site 272620006788 D-loop; other site 272620006789 H-loop/switch region; other site 272620006790 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 272620006791 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620006792 N-terminal plug; other site 272620006793 ligand-binding site [chemical binding]; other site 272620006794 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272620006795 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272620006796 Walker A/P-loop; other site 272620006797 ATP binding site [chemical binding]; other site 272620006798 Q-loop/lid; other site 272620006799 ABC transporter signature motif; other site 272620006800 Walker B; other site 272620006801 D-loop; other site 272620006802 H-loop/switch region; other site 272620006803 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272620006804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620006805 dimer interface [polypeptide binding]; other site 272620006806 conserved gate region; other site 272620006807 putative PBP binding loops; other site 272620006808 ABC-ATPase subunit interface; other site 272620006809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272620006810 NMT1/THI5 like; Region: NMT1; pfam09084 272620006811 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620006812 membrane-bound complex binding site; other site 272620006813 hinge residues; other site 272620006814 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 272620006815 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 272620006816 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 272620006817 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272620006818 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 272620006819 dimer interface [polypeptide binding]; other site 272620006820 active site 272620006821 non-prolyl cis peptide bond; other site 272620006822 insertion regions; other site 272620006823 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620006824 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006825 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620006826 dimerization interface [polypeptide binding]; other site 272620006827 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 272620006828 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 272620006829 active site residue [active] 272620006830 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 272620006831 active site residue [active] 272620006832 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 272620006833 active site residue [active] 272620006834 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 272620006835 active site residue [active] 272620006836 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 272620006837 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 272620006838 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 272620006839 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 272620006840 active site 272620006841 catalytic residues [active] 272620006842 metal binding site [ion binding]; metal-binding site 272620006843 DmpG-like communication domain; Region: DmpG_comm; pfam07836 272620006844 acetaldehyde dehydrogenase; Validated; Region: PRK08300 272620006845 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272620006846 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 272620006847 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 272620006848 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 272620006849 Sugar fermentation stimulation protein; Region: SfsA; cl00647 272620006850 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 272620006851 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 272620006852 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 272620006853 putative active site [active] 272620006854 Fe(II) binding site [ion binding]; other site 272620006855 putative dimer interface [polypeptide binding]; other site 272620006856 putative tetramer interface [polypeptide binding]; other site 272620006857 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 272620006858 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272620006859 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 272620006860 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620006861 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620006862 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 272620006863 putative ligand binding residues [chemical binding]; other site 272620006864 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272620006865 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 272620006866 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620006867 ABC-ATPase subunit interface; other site 272620006868 dimer interface [polypeptide binding]; other site 272620006869 putative PBP binding regions; other site 272620006870 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272620006871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620006872 Walker A/P-loop; other site 272620006873 ATP binding site [chemical binding]; other site 272620006874 Q-loop/lid; other site 272620006875 ABC transporter signature motif; other site 272620006876 Walker B; other site 272620006877 D-loop; other site 272620006878 H-loop/switch region; other site 272620006879 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272620006880 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272620006881 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 272620006882 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272620006883 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272620006884 shikimate binding site; other site 272620006885 NAD(P) binding site [chemical binding]; other site 272620006886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620006887 D-galactonate transporter; Region: 2A0114; TIGR00893 272620006888 putative substrate translocation pore; other site 272620006889 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272620006890 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 272620006891 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 272620006892 active site 272620006893 Fe binding site [ion binding]; other site 272620006894 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 272620006895 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620006896 Protein of unknown function (DUF2767); Region: DUF2767; pfam10965 272620006897 pyruvate kinase; Provisional; Region: PRK09206 272620006898 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272620006899 domain interfaces; other site 272620006900 active site 272620006901 murein lipoprotein; Provisional; Region: PRK15396 272620006902 L,D-transpeptidase; Provisional; Region: PRK10260 272620006903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620006904 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272620006905 cysteine desufuration protein SufE; Provisional; Region: PRK09296 272620006906 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272620006907 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272620006908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620006909 catalytic residue [active] 272620006910 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 272620006911 FeS assembly protein SufD; Region: sufD; TIGR01981 272620006912 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 272620006913 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272620006914 Walker A/P-loop; other site 272620006915 ATP binding site [chemical binding]; other site 272620006916 Q-loop/lid; other site 272620006917 ABC transporter signature motif; other site 272620006918 Walker B; other site 272620006919 D-loop; other site 272620006920 H-loop/switch region; other site 272620006921 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 272620006922 putative ABC transporter; Region: ycf24; CHL00085 272620006923 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 272620006924 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 272620006925 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272620006926 phosphate binding site [ion binding]; other site 272620006927 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272620006928 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272620006929 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620006930 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620006931 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620006932 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272620006933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620006934 NAD(P) binding site [chemical binding]; other site 272620006935 active site 272620006936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620006937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620006938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620006939 dimerization interface [polypeptide binding]; other site 272620006940 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 272620006941 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 272620006942 intersubunit interface [polypeptide binding]; other site 272620006943 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620006944 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620006945 ABC-ATPase subunit interface; other site 272620006946 dimer interface [polypeptide binding]; other site 272620006947 putative PBP binding regions; other site 272620006948 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272620006949 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620006950 Walker A/P-loop; other site 272620006951 ATP binding site [chemical binding]; other site 272620006952 Q-loop/lid; other site 272620006953 ABC transporter signature motif; other site 272620006954 Walker B; other site 272620006955 D-loop; other site 272620006956 H-loop/switch region; other site 272620006957 methionine synthase; Provisional; Region: PRK01207 272620006958 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272620006959 substrate binding site [chemical binding]; other site 272620006960 THF binding site; other site 272620006961 zinc-binding site [ion binding]; other site 272620006962 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 272620006963 hypothetical protein; Provisional; Region: PRK10457 272620006964 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272620006965 CoenzymeA binding site [chemical binding]; other site 272620006966 subunit interaction site [polypeptide binding]; other site 272620006967 PHB binding site; other site 272620006968 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 272620006969 FAD binding domain; Region: FAD_binding_4; pfam01565 272620006970 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 272620006971 putative inner membrane protein; Provisional; Region: PRK10983 272620006972 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272620006973 phosphoenolpyruvate synthase; Validated; Region: PRK06464 272620006974 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 272620006975 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272620006976 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272620006977 PEP synthetase regulatory protein; Provisional; Region: PRK05339 272620006978 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 272620006979 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272620006980 hypothetical protein; Provisional; Region: PRK10183 272620006981 Uncharacterized conserved protein [Function unknown]; Region: COG0397 272620006982 hypothetical protein; Validated; Region: PRK00029 272620006983 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 272620006984 NlpC/P60 family; Region: NLPC_P60; pfam00877 272620006985 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 272620006986 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620006987 Walker A/P-loop; other site 272620006988 ATP binding site [chemical binding]; other site 272620006989 Q-loop/lid; other site 272620006990 ABC transporter signature motif; other site 272620006991 Walker B; other site 272620006992 D-loop; other site 272620006993 H-loop/switch region; other site 272620006994 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272620006995 catalytic residues [active] 272620006996 dimer interface [polypeptide binding]; other site 272620006997 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 272620006998 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 272620006999 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620007000 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620007001 ABC-ATPase subunit interface; other site 272620007002 dimer interface [polypeptide binding]; other site 272620007003 putative PBP binding regions; other site 272620007004 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620007005 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007006 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620007007 dimerization interface [polypeptide binding]; other site 272620007008 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 272620007009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620007010 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 272620007011 homotrimer interaction site [polypeptide binding]; other site 272620007012 putative active site [active] 272620007013 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272620007014 IHF dimer interface [polypeptide binding]; other site 272620007015 IHF - DNA interface [nucleotide binding]; other site 272620007016 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272620007017 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272620007018 putative tRNA-binding site [nucleotide binding]; other site 272620007019 B3/4 domain; Region: B3_4; pfam03483 272620007020 tRNA synthetase B5 domain; Region: B5; smart00874 272620007021 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272620007022 dimer interface [polypeptide binding]; other site 272620007023 motif 1; other site 272620007024 motif 3; other site 272620007025 motif 2; other site 272620007026 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272620007027 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272620007028 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272620007029 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272620007030 dimer interface [polypeptide binding]; other site 272620007031 motif 1; other site 272620007032 active site 272620007033 motif 2; other site 272620007034 motif 3; other site 272620007035 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272620007036 23S rRNA binding site [nucleotide binding]; other site 272620007037 L21 binding site [polypeptide binding]; other site 272620007038 L13 binding site [polypeptide binding]; other site 272620007039 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272620007040 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272620007041 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272620007042 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272620007043 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272620007044 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272620007045 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272620007046 active site 272620007047 dimer interface [polypeptide binding]; other site 272620007048 motif 1; other site 272620007049 motif 2; other site 272620007050 motif 3; other site 272620007051 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272620007052 anticodon binding site; other site 272620007053 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 272620007054 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 272620007055 6-phosphofructokinase 2; Provisional; Region: PRK10294 272620007056 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272620007057 putative substrate binding site [chemical binding]; other site 272620007058 putative ATP binding site [chemical binding]; other site 272620007059 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 272620007060 Phosphotransferase enzyme family; Region: APH; pfam01636 272620007061 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272620007062 active site 272620007063 ATP binding site [chemical binding]; other site 272620007064 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272620007065 active site 272620007066 ATP binding site [chemical binding]; other site 272620007067 transport protein TonB; Provisional; Region: PRK10819 272620007068 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 272620007069 YciI-like protein; Reviewed; Region: PRK11370 272620007070 Uncharacterized conserved protein [Function unknown]; Region: COG2353 272620007071 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 272620007072 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272620007073 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 272620007074 putative active site [active] 272620007075 catalytic site [active] 272620007076 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 272620007077 putative active site [active] 272620007078 catalytic site [active] 272620007079 dsDNA-mimic protein; Reviewed; Region: PRK05094 272620007080 Ion transport protein; Region: Ion_trans; pfam00520 272620007081 Ion channel; Region: Ion_trans_2; pfam07885 272620007082 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 272620007083 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620007084 Walker A/P-loop; other site 272620007085 ATP binding site [chemical binding]; other site 272620007086 Q-loop/lid; other site 272620007087 ABC transporter signature motif; other site 272620007088 Walker B; other site 272620007089 D-loop; other site 272620007090 H-loop/switch region; other site 272620007091 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272620007092 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 272620007093 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620007094 Walker A/P-loop; other site 272620007095 ATP binding site [chemical binding]; other site 272620007096 Q-loop/lid; other site 272620007097 ABC transporter signature motif; other site 272620007098 Walker B; other site 272620007099 D-loop; other site 272620007100 H-loop/switch region; other site 272620007101 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272620007102 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 272620007103 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620007104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620007105 dimer interface [polypeptide binding]; other site 272620007106 conserved gate region; other site 272620007107 ABC-ATPase subunit interface; other site 272620007108 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 272620007109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620007110 dimer interface [polypeptide binding]; other site 272620007111 conserved gate region; other site 272620007112 putative PBP binding loops; other site 272620007113 ABC-ATPase subunit interface; other site 272620007114 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 272620007115 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 272620007116 peptide binding site [polypeptide binding]; other site 272620007117 hypothetical protein; Provisional; Region: PRK11111 272620007118 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 272620007119 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 272620007120 putative catalytic cysteine [active] 272620007121 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 272620007122 putative active site [active] 272620007123 metal binding site [ion binding]; metal-binding site 272620007124 thymidine kinase; Provisional; Region: PRK04296 272620007125 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 272620007126 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 272620007127 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272620007128 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272620007129 active site 272620007130 tetramer interface; other site 272620007131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620007132 active site 272620007133 response regulator of RpoS; Provisional; Region: PRK10693 272620007134 phosphorylation site [posttranslational modification] 272620007135 intermolecular recognition site; other site 272620007136 dimerization interface [polypeptide binding]; other site 272620007137 hypothetical protein; Provisional; Region: PRK10279 272620007138 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 272620007139 nucleophile elbow; other site 272620007140 hypothetical protein; Provisional; Region: PRK01617 272620007141 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 272620007142 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 272620007143 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 272620007144 putative active site [active] 272620007145 putative substrate binding site [chemical binding]; other site 272620007146 putative cosubstrate binding site; other site 272620007147 catalytic site [active] 272620007148 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 272620007149 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272620007150 AsnC family; Region: AsnC_trans_reg; pfam01037 272620007151 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 272620007152 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 272620007153 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 272620007154 4Fe-4S binding domain; Region: Fer4; cl02805 272620007155 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 272620007156 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 272620007157 [4Fe-4S] binding site [ion binding]; other site 272620007158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620007159 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620007160 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620007161 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 272620007162 molybdopterin cofactor binding site; other site 272620007163 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 272620007164 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 272620007165 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 272620007166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620007167 dimerization interface [polypeptide binding]; other site 272620007168 Histidine kinase; Region: HisKA_3; pfam07730 272620007169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620007170 ATP binding site [chemical binding]; other site 272620007171 Mg2+ binding site [ion binding]; other site 272620007172 G-X-G motif; other site 272620007173 transcriptional regulator NarL; Provisional; Region: PRK10651 272620007174 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620007175 active site 272620007176 phosphorylation site [posttranslational modification] 272620007177 intermolecular recognition site; other site 272620007178 dimerization interface [polypeptide binding]; other site 272620007179 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620007180 DNA binding residues [nucleotide binding] 272620007181 dimerization interface [polypeptide binding]; other site 272620007182 putative invasin; Provisional; Region: PRK10177 272620007183 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 272620007184 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 272620007185 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 272620007186 [4Fe-4S] binding site [ion binding]; other site 272620007187 molybdopterin cofactor binding site; other site 272620007188 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 272620007189 molybdopterin cofactor binding site; other site 272620007190 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272620007191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 272620007192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620007193 nitrite reductase subunit NirD; Provisional; Region: PRK14989 272620007194 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620007195 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272620007196 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272620007197 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 272620007198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 272620007199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 272620007200 Walker A/P-loop; other site 272620007201 ATP binding site [chemical binding]; other site 272620007202 Q-loop/lid; other site 272620007203 ABC transporter signature motif; other site 272620007204 Walker B; other site 272620007205 D-loop; other site 272620007206 H-loop/switch region; other site 272620007207 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 272620007208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620007209 dimer interface [polypeptide binding]; other site 272620007210 conserved gate region; other site 272620007211 putative PBP binding loops; other site 272620007212 ABC-ATPase subunit interface; other site 272620007213 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 272620007214 NMT1-like family; Region: NMT1_2; pfam13379 272620007215 Nitrate and nitrite sensing; Region: NIT; pfam08376 272620007216 ANTAR domain; Region: ANTAR; pfam03861 272620007217 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 272620007218 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 272620007219 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 272620007220 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272620007221 putative active site pocket [active] 272620007222 dimerization interface [polypeptide binding]; other site 272620007223 putative catalytic residue [active] 272620007224 cation transport regulator; Reviewed; Region: chaB; PRK09582 272620007225 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 272620007226 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272620007227 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 272620007228 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272620007229 hypothetical protein; Provisional; Region: PRK10941 272620007230 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 272620007231 hypothetical protein; Provisional; Region: PRK10278 272620007232 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 272620007233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620007234 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272620007235 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272620007236 RF-1 domain; Region: RF-1; pfam00472 272620007237 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 272620007238 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 272620007239 tRNA; other site 272620007240 putative tRNA binding site [nucleotide binding]; other site 272620007241 putative NADP binding site [chemical binding]; other site 272620007242 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 272620007243 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 272620007244 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 272620007245 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 272620007246 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272620007247 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 272620007248 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272620007249 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272620007250 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620007251 active site 272620007252 putative transporter; Provisional; Region: PRK11660 272620007253 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272620007254 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272620007255 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272620007256 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 272620007257 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 272620007258 DNA binding residues [nucleotide binding] 272620007259 putative dimer interface [polypeptide binding]; other site 272620007260 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 272620007261 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 272620007262 hypothetical protein; Provisional; Region: PRK10692 272620007263 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272620007264 putative active site [active] 272620007265 catalytic residue [active] 272620007266 GTP-binding protein YchF; Reviewed; Region: PRK09601 272620007267 YchF GTPase; Region: YchF; cd01900 272620007268 G1 box; other site 272620007269 GTP/Mg2+ binding site [chemical binding]; other site 272620007270 Switch I region; other site 272620007271 G2 box; other site 272620007272 Switch II region; other site 272620007273 G3 box; other site 272620007274 G4 box; other site 272620007275 G5 box; other site 272620007276 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272620007277 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 272620007278 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620007279 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272620007280 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 272620007281 ImpA domain protein; Region: DUF3702; pfam12486 272620007282 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 272620007283 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 272620007284 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 272620007285 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 272620007286 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 272620007287 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 272620007288 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 272620007289 PAAR motif; Region: PAAR_motif; pfam05488 272620007290 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272620007291 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272620007292 Uncharacterized conserved protein [Function unknown]; Region: COG1262 272620007293 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 272620007294 S-type Pyocin; Region: Pyocin_S; pfam06958 272620007295 S-type Pyocin; Region: Pyocin_S; pfam06958 272620007296 S-type Pyocin; Region: Pyocin_S; pfam06958 272620007297 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 272620007298 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 272620007299 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 272620007300 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 272620007301 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 272620007302 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272620007303 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620007304 ligand binding site [chemical binding]; other site 272620007305 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 272620007306 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 272620007307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 272620007308 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272620007309 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272620007310 active site 272620007311 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272620007312 DNA-binding site [nucleotide binding]; DNA binding site 272620007313 RNA-binding motif; other site 272620007314 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620007315 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007316 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 272620007317 putative dimerization interface [polypeptide binding]; other site 272620007318 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272620007319 citrate-proton symporter; Provisional; Region: PRK15075 272620007320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620007321 putative substrate translocation pore; other site 272620007322 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 272620007323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620007325 dimerization interface [polypeptide binding]; other site 272620007326 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620007327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620007328 Coenzyme A binding pocket [chemical binding]; other site 272620007329 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 272620007330 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 272620007331 active site 272620007332 substrate-binding site [chemical binding]; other site 272620007333 metal-binding site [ion binding] 272620007334 ATP binding site [chemical binding]; other site 272620007335 cell density-dependent motility repressor; Provisional; Region: PRK10082 272620007336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007337 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620007338 dimerization interface [polypeptide binding]; other site 272620007339 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 272620007340 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272620007341 Walker A/P-loop; other site 272620007342 ATP binding site [chemical binding]; other site 272620007343 Q-loop/lid; other site 272620007344 ABC transporter signature motif; other site 272620007345 Walker B; other site 272620007346 D-loop; other site 272620007347 H-loop/switch region; other site 272620007348 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 272620007349 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272620007350 Walker A/P-loop; other site 272620007351 ATP binding site [chemical binding]; other site 272620007352 Q-loop/lid; other site 272620007353 ABC transporter signature motif; other site 272620007354 Walker B; other site 272620007355 D-loop; other site 272620007356 H-loop/switch region; other site 272620007357 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 272620007358 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 272620007359 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272620007360 TM-ABC transporter signature motif; other site 272620007361 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620007362 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272620007363 TM-ABC transporter signature motif; other site 272620007364 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272620007365 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 272620007366 dimerization interface [polypeptide binding]; other site 272620007367 ligand binding site [chemical binding]; other site 272620007368 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 272620007369 Pyruvate formate lyase 1; Region: PFL1; cd01678 272620007370 coenzyme A binding site [chemical binding]; other site 272620007371 active site 272620007372 catalytic residues [active] 272620007373 glycine loop; other site 272620007374 propionate/acetate kinase; Provisional; Region: PRK12379 272620007375 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 272620007376 threonine/serine transporter TdcC; Provisional; Region: PRK13629 272620007377 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272620007378 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 272620007379 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272620007380 tetramer interface [polypeptide binding]; other site 272620007381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620007382 catalytic residue [active] 272620007383 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 272620007384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007385 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620007386 dimerization interface [polypeptide binding]; other site 272620007387 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 272620007388 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 272620007389 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 272620007390 putative di-iron ligands [ion binding]; other site 272620007391 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 272620007392 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 272620007393 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 272620007394 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 272620007395 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272620007396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 272620007397 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 272620007398 Uncharacterized conserved protein [Function unknown]; Region: COG2308 272620007399 trehalase; Provisional; Region: treA; PRK13271 272620007400 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 272620007401 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 272620007402 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620007403 N-terminal plug; other site 272620007404 ligand-binding site [chemical binding]; other site 272620007405 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 272620007406 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620007407 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620007408 catalytic residue [active] 272620007409 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 272620007410 dimer interface [polypeptide binding]; other site 272620007411 catalytic triad [active] 272620007412 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 272620007413 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272620007414 TrkA-C domain; Region: TrkA_C; pfam02080 272620007415 Transporter associated domain; Region: CorC_HlyC; smart01091 272620007416 alanine racemase; Reviewed; Region: dadX; PRK03646 272620007417 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 272620007418 active site 272620007419 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272620007420 substrate binding site [chemical binding]; other site 272620007421 catalytic residues [active] 272620007422 dimer interface [polypeptide binding]; other site 272620007423 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 272620007424 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272620007425 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272620007426 SpoVR family protein; Provisional; Region: PRK11767 272620007427 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 272620007428 fatty acid metabolism regulator; Provisional; Region: PRK04984 272620007429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620007430 DNA-binding site [nucleotide binding]; DNA binding site 272620007431 FadR C-terminal domain; Region: FadR_C; pfam07840 272620007432 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 272620007433 transmembrane helices; other site 272620007434 disulfide bond formation protein B; Provisional; Region: PRK01749 272620007435 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 272620007436 hypothetical protein; Provisional; Region: PRK05170 272620007437 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 272620007438 hypothetical protein; Provisional; Region: PRK10691 272620007439 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 272620007440 septum formation inhibitor; Reviewed; Region: minC; PRK03511 272620007441 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 272620007442 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 272620007443 cell division inhibitor MinD; Provisional; Region: PRK10818 272620007444 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 272620007445 Switch I; other site 272620007446 Switch II; other site 272620007447 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 272620007448 ribonuclease D; Provisional; Region: PRK10829 272620007449 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 272620007450 catalytic site [active] 272620007451 putative active site [active] 272620007452 putative substrate binding site [chemical binding]; other site 272620007453 Helicase and RNase D C-terminal; Region: HRDC; smart00341 272620007454 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 272620007455 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 272620007456 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 272620007457 acyl-activating enzyme (AAE) consensus motif; other site 272620007458 putative AMP binding site [chemical binding]; other site 272620007459 putative active site [active] 272620007460 putative CoA binding site [chemical binding]; other site 272620007461 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 272620007462 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272620007463 Glycoprotease family; Region: Peptidase_M22; pfam00814 272620007464 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 272620007465 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272620007466 DEAD_2; Region: DEAD_2; pfam06733 272620007467 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 272620007468 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 272620007469 homotrimer interaction site [polypeptide binding]; other site 272620007470 putative active site [active] 272620007471 hypothetical protein; Provisional; Region: PRK05114 272620007472 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 272620007473 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 272620007474 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 272620007475 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 272620007476 putative active site [active] 272620007477 putative CoA binding site [chemical binding]; other site 272620007478 nudix motif; other site 272620007479 metal binding site [ion binding]; metal-binding site 272620007480 L-serine deaminase; Provisional; Region: PRK15023 272620007481 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272620007482 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272620007483 phage resistance protein; Provisional; Region: PRK10551 272620007484 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620007485 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620007486 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 272620007487 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272620007488 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272620007489 Transporter associated domain; Region: CorC_HlyC; smart01091 272620007490 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 272620007491 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620007492 active pocket/dimerization site; other site 272620007493 active site 272620007494 phosphorylation site [posttranslational modification] 272620007495 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272620007496 active site 272620007497 phosphorylation site [posttranslational modification] 272620007498 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272620007499 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 272620007500 hypothetical protein; Provisional; Region: PRK02913 272620007501 hypothetical protein; Provisional; Region: PRK11469 272620007502 Domain of unknown function DUF; Region: DUF204; pfam02659 272620007503 Domain of unknown function DUF; Region: DUF204; pfam02659 272620007504 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 272620007505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620007506 S-adenosylmethionine binding site [chemical binding]; other site 272620007507 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 272620007508 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 272620007509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 272620007510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272620007511 DNA-binding site [nucleotide binding]; DNA binding site 272620007512 RNA-binding motif; other site 272620007513 YebO-like protein; Region: YebO; pfam13974 272620007514 YobH-like protein; Region: YobH; pfam13996 272620007515 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 272620007516 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620007517 dimerization interface [polypeptide binding]; other site 272620007518 putative Zn2+ binding site [ion binding]; other site 272620007519 putative DNA binding site [nucleotide binding]; other site 272620007520 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620007521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620007522 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620007523 putative substrate translocation pore; other site 272620007524 heat shock protein HtpX; Provisional; Region: PRK05457 272620007525 carboxy-terminal protease; Provisional; Region: PRK11186 272620007526 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 272620007527 protein binding site [polypeptide binding]; other site 272620007528 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 272620007529 Catalytic dyad [active] 272620007530 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 272620007531 ProP expression regulator; Provisional; Region: PRK04950 272620007532 ProQ/FINO family; Region: ProQ; pfam04352 272620007533 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 272620007534 GAF domain; Region: GAF_2; pfam13185 272620007535 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 272620007536 Paraquat-inducible protein A; Region: PqiA; pfam04403 272620007537 Paraquat-inducible protein A; Region: PqiA; pfam04403 272620007538 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 272620007539 mce related protein; Region: MCE; pfam02470 272620007540 mce related protein; Region: MCE; pfam02470 272620007541 mce related protein; Region: MCE; pfam02470 272620007542 mce related protein; Region: MCE; pfam02470 272620007543 mce related protein; Region: MCE; pfam02470 272620007544 mce related protein; Region: MCE; pfam02470 272620007545 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 272620007546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620007547 S-adenosylmethionine binding site [chemical binding]; other site 272620007548 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 272620007549 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 272620007550 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 272620007551 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 272620007552 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272620007553 Protein of unknown function (DUF535); Region: DUF535; pfam04393 272620007554 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 272620007555 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 272620007556 CopC domain; Region: CopC; cl01012 272620007557 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 272620007558 exodeoxyribonuclease X; Provisional; Region: PRK07983 272620007559 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272620007560 active site 272620007561 catalytic site [active] 272620007562 substrate binding site [chemical binding]; other site 272620007563 protease 2; Provisional; Region: PRK10115 272620007564 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272620007565 Protein of unknown function (DUF533); Region: DUF533; pfam04391 272620007566 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 272620007567 putative metal binding site [ion binding]; other site 272620007568 YebG protein; Region: YebG; pfam07130 272620007569 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 272620007570 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272620007571 ATP-grasp domain; Region: ATP-grasp; pfam02222 272620007572 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 272620007573 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272620007574 active site 272620007575 intersubunit interface [polypeptide binding]; other site 272620007576 catalytic residue [active] 272620007577 phosphogluconate dehydratase; Validated; Region: PRK09054 272620007578 6-phosphogluconate dehydratase; Region: edd; TIGR01196 272620007579 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 272620007580 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 272620007581 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 272620007582 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 272620007583 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620007584 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620007585 putative active site [active] 272620007586 pyruvate kinase; Provisional; Region: PRK05826 272620007587 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272620007588 domain interfaces; other site 272620007589 active site 272620007590 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 272620007591 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 272620007592 putative acyl-acceptor binding pocket; other site 272620007593 putative peptidase; Provisional; Region: PRK11649 272620007594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620007595 Peptidase family M23; Region: Peptidase_M23; pfam01551 272620007596 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 272620007597 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 272620007598 metal binding site [ion binding]; metal-binding site 272620007599 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 272620007600 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272620007601 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272620007602 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620007603 ABC-ATPase subunit interface; other site 272620007604 dimer interface [polypeptide binding]; other site 272620007605 putative PBP binding regions; other site 272620007606 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272620007607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620007608 Walker A motif; other site 272620007609 ATP binding site [chemical binding]; other site 272620007610 Walker B motif; other site 272620007611 arginine finger; other site 272620007612 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272620007613 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272620007614 RuvA N terminal domain; Region: RuvA_N; pfam01330 272620007615 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272620007616 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 272620007617 active site 272620007618 putative DNA-binding cleft [nucleotide binding]; other site 272620007619 dimer interface [polypeptide binding]; other site 272620007620 hypothetical protein; Validated; Region: PRK00110 272620007621 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 272620007622 nudix motif; other site 272620007623 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272620007624 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272620007625 dimer interface [polypeptide binding]; other site 272620007626 anticodon binding site; other site 272620007627 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272620007628 homodimer interface [polypeptide binding]; other site 272620007629 motif 1; other site 272620007630 active site 272620007631 motif 2; other site 272620007632 GAD domain; Region: GAD; pfam02938 272620007633 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272620007634 active site 272620007635 motif 3; other site 272620007636 Isochorismatase family; Region: Isochorismatase; pfam00857 272620007637 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 272620007638 catalytic triad [active] 272620007639 conserved cis-peptide bond; other site 272620007640 hypothetical protein; Provisional; Region: PRK10302 272620007641 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 272620007642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620007643 S-adenosylmethionine binding site [chemical binding]; other site 272620007644 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272620007645 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620007646 S-adenosylmethionine binding site [chemical binding]; other site 272620007647 copper homeostasis protein CutC; Provisional; Region: PRK11572 272620007648 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 272620007649 putative metal binding site [ion binding]; other site 272620007650 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272620007651 arginyl-tRNA synthetase; Region: argS; TIGR00456 272620007652 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272620007653 active site 272620007654 HIGH motif; other site 272620007655 KMSK motif region; other site 272620007656 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 272620007657 tRNA binding surface [nucleotide binding]; other site 272620007658 anticodon binding site; other site 272620007659 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 272620007660 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620007661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620007662 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620007663 Ligand Binding Site [chemical binding]; other site 272620007664 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 272620007665 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 272620007666 active site 272620007667 homotetramer interface [polypeptide binding]; other site 272620007668 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 272620007669 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 272620007670 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620007671 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620007672 TM-ABC transporter signature motif; other site 272620007673 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 272620007674 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620007675 Walker A/P-loop; other site 272620007676 ATP binding site [chemical binding]; other site 272620007677 Q-loop/lid; other site 272620007678 ABC transporter signature motif; other site 272620007679 Walker B; other site 272620007680 D-loop; other site 272620007681 H-loop/switch region; other site 272620007682 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620007683 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 272620007684 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 272620007685 ligand binding site [chemical binding]; other site 272620007686 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 272620007687 Ferritin-like domain; Region: Ferritin; pfam00210 272620007688 ferroxidase diiron center [ion binding]; other site 272620007689 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620007690 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 272620007691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620007692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620007693 putative substrate translocation pore; other site 272620007694 hypothetical protein; Provisional; Region: PRK09273 272620007695 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 272620007696 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 272620007697 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 272620007698 Ferritin-like domain; Region: Ferritin; pfam00210 272620007699 ferroxidase diiron center [ion binding]; other site 272620007700 probable metal-binding protein; Region: matur_matur; TIGR03853 272620007701 tyrosine transporter TyrP; Provisional; Region: PRK15132 272620007702 aromatic amino acid transport protein; Region: araaP; TIGR00837 272620007703 hypothetical protein; Provisional; Region: PRK10396 272620007704 yecA family protein; Region: ygfB_yecA; TIGR02292 272620007705 SEC-C motif; Region: SEC-C; pfam02810 272620007706 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 272620007707 active site 272620007708 inhibitor site; inhibition site 272620007709 dimer interface [polypeptide binding]; other site 272620007710 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 272620007711 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272620007712 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272620007713 active site 272620007714 catalytic site [active] 272620007715 putative DNA binding site [nucleotide binding]; other site 272620007716 GIY-YIG motif/motif A; other site 272620007717 metal binding site [ion binding]; metal-binding site 272620007718 UvrB/uvrC motif; Region: UVR; pfam02151 272620007719 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272620007720 response regulator; Provisional; Region: PRK09483 272620007721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620007722 active site 272620007723 phosphorylation site [posttranslational modification] 272620007724 intermolecular recognition site; other site 272620007725 dimerization interface [polypeptide binding]; other site 272620007726 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620007727 DNA binding residues [nucleotide binding] 272620007728 dimerization interface [polypeptide binding]; other site 272620007729 hypothetical protein; Provisional; Region: PRK10613 272620007730 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 272620007731 Autoinducer binding domain; Region: Autoind_bind; pfam03472 272620007732 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620007733 DNA binding residues [nucleotide binding] 272620007734 dimerization interface [polypeptide binding]; other site 272620007735 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 272620007736 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620007737 Walker A/P-loop; other site 272620007738 ATP binding site [chemical binding]; other site 272620007739 Q-loop/lid; other site 272620007740 ABC transporter signature motif; other site 272620007741 Walker B; other site 272620007742 D-loop; other site 272620007743 H-loop/switch region; other site 272620007744 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620007745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620007746 dimer interface [polypeptide binding]; other site 272620007747 conserved gate region; other site 272620007748 putative PBP binding loops; other site 272620007749 ABC-ATPase subunit interface; other site 272620007750 D-cysteine desulfhydrase; Validated; Region: PRK03910 272620007751 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 272620007752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620007753 catalytic residue [active] 272620007754 cystine transporter subunit; Provisional; Region: PRK11260 272620007755 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620007756 substrate binding pocket [chemical binding]; other site 272620007757 membrane-bound complex binding site; other site 272620007758 hinge residues; other site 272620007759 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 272620007760 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 272620007761 active site 272620007762 Na/Ca binding site [ion binding]; other site 272620007763 catalytic site [active] 272620007764 lipoprotein; Provisional; Region: PRK10397 272620007765 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 272620007766 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620007767 DNA binding residues [nucleotide binding] 272620007768 dimerization interface [polypeptide binding]; other site 272620007769 hypothetical protein; Provisional; Region: PRK10708 272620007770 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 272620007771 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 272620007772 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620007773 metal binding site [ion binding]; metal-binding site 272620007774 active site 272620007775 I-site; other site 272620007776 hypothetical protein; Provisional; Region: PRK10062 272620007777 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 272620007778 EamA-like transporter family; Region: EamA; pfam00892 272620007779 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 272620007780 additional DNA contacts [nucleotide binding]; other site 272620007781 mismatch recognition site; other site 272620007782 active site 272620007783 zinc binding site [ion binding]; other site 272620007784 DNA intercalation site [nucleotide binding]; other site 272620007785 DNA cytosine methylase; Provisional; Region: PRK10458 272620007786 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272620007787 cofactor binding site; other site 272620007788 DNA binding site [nucleotide binding] 272620007789 substrate interaction site [chemical binding]; other site 272620007790 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272620007791 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620007792 Zn2+ binding site [ion binding]; other site 272620007793 Mg2+ binding site [ion binding]; other site 272620007794 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 272620007795 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 272620007796 trimer interface [polypeptide binding]; other site 272620007797 eyelet of channel; other site 272620007798 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 272620007799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620007800 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620007801 putative effector binding pocket; other site 272620007802 putative dimerization interface [polypeptide binding]; other site 272620007803 L,D-transpeptidase; Provisional; Region: PRK10190 272620007804 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 272620007805 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 272620007806 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620007807 dimerization interface [polypeptide binding]; other site 272620007808 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 272620007809 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007810 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 272620007811 putative dimerization interface [polypeptide binding]; other site 272620007812 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 272620007813 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272620007814 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 272620007815 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620007816 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620007817 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 272620007818 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 272620007819 NADP binding site [chemical binding]; other site 272620007820 dimer interface [polypeptide binding]; other site 272620007821 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272620007822 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272620007823 signal transduction protein PmrD; Provisional; Region: PRK15450 272620007824 AMP nucleosidase; Provisional; Region: PRK08292 272620007825 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 272620007826 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 272620007827 MATE family multidrug exporter; Provisional; Region: PRK10189 272620007828 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 272620007829 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 272620007830 active site 272620007831 substrate binding site [chemical binding]; other site 272620007832 ATP binding site [chemical binding]; other site 272620007833 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272620007834 GAF domain; Region: GAF; pfam01590 272620007835 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620007836 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620007837 metal binding site [ion binding]; metal-binding site 272620007838 active site 272620007839 I-site; other site 272620007840 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272620007841 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272620007842 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272620007843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007844 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620007845 dimerization interface [polypeptide binding]; other site 272620007846 substrate binding pocket [chemical binding]; other site 272620007847 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 272620007848 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 272620007849 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620007850 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620007851 metal binding site [ion binding]; metal-binding site 272620007852 active site 272620007853 I-site; other site 272620007854 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620007855 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 272620007856 shikimate transporter; Provisional; Region: PRK09952 272620007857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620007858 putative substrate translocation pore; other site 272620007859 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272620007860 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620007861 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007862 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620007863 putative effector binding pocket; other site 272620007864 dimerization interface [polypeptide binding]; other site 272620007865 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 272620007866 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 272620007867 NAD binding site [chemical binding]; other site 272620007868 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 272620007869 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272620007870 putative dimer interface [polypeptide binding]; other site 272620007871 active site pocket [active] 272620007872 putative cataytic base [active] 272620007873 cobalamin synthase; Reviewed; Region: cobS; PRK00235 272620007874 hypothetical protein; Provisional; Region: PRK05423 272620007875 Predicted membrane protein [Function unknown]; Region: COG1289 272620007876 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272620007877 DNA gyrase inhibitor; Provisional; Region: PRK10016 272620007878 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 272620007879 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 272620007880 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 272620007881 exonuclease I; Provisional; Region: sbcB; PRK11779 272620007882 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 272620007883 active site 272620007884 catalytic site [active] 272620007885 substrate binding site [chemical binding]; other site 272620007886 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 272620007887 elongation factor G; Reviewed; Region: PRK00007 272620007888 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272620007889 G1 box; other site 272620007890 putative GEF interaction site [polypeptide binding]; other site 272620007891 GTP/Mg2+ binding site [chemical binding]; other site 272620007892 Switch I region; other site 272620007893 G2 box; other site 272620007894 G3 box; other site 272620007895 Switch II region; other site 272620007896 G4 box; other site 272620007897 G5 box; other site 272620007898 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272620007899 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272620007900 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272620007901 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620007902 dimerization interface [polypeptide binding]; other site 272620007903 putative DNA binding site [nucleotide binding]; other site 272620007904 putative Zn2+ binding site [ion binding]; other site 272620007905 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272620007906 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620007907 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620007908 dimerization interface [polypeptide binding]; other site 272620007909 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272620007910 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 272620007911 putative NAD(P) binding site [chemical binding]; other site 272620007912 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 272620007913 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 272620007914 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 272620007915 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 272620007916 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 272620007917 NAD binding site [chemical binding]; other site 272620007918 dimerization interface [polypeptide binding]; other site 272620007919 product binding site; other site 272620007920 substrate binding site [chemical binding]; other site 272620007921 zinc binding site [ion binding]; other site 272620007922 catalytic residues [active] 272620007923 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 272620007924 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620007925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620007926 homodimer interface [polypeptide binding]; other site 272620007927 catalytic residue [active] 272620007928 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 272620007929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620007930 active site 272620007931 motif I; other site 272620007932 motif II; other site 272620007933 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 272620007934 putative active site pocket [active] 272620007935 4-fold oligomerization interface [polypeptide binding]; other site 272620007936 metal binding residues [ion binding]; metal-binding site 272620007937 3-fold/trimer interface [polypeptide binding]; other site 272620007938 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 272620007939 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 272620007940 putative active site [active] 272620007941 oxyanion strand; other site 272620007942 catalytic triad [active] 272620007943 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 272620007944 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 272620007945 catalytic residues [active] 272620007946 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 272620007947 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 272620007948 substrate binding site [chemical binding]; other site 272620007949 glutamase interaction surface [polypeptide binding]; other site 272620007950 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 272620007951 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 272620007952 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 272620007953 metal binding site [ion binding]; metal-binding site 272620007954 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272620007955 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 272620007956 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272620007957 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272620007958 Probable Catalytic site; other site 272620007959 metal-binding site 272620007960 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272620007961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272620007962 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 272620007963 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 272620007964 Walker A/P-loop; other site 272620007965 ATP binding site [chemical binding]; other site 272620007966 Q-loop/lid; other site 272620007967 ABC transporter signature motif; other site 272620007968 Walker B; other site 272620007969 D-loop; other site 272620007970 H-loop/switch region; other site 272620007971 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 272620007972 putative carbohydrate binding site [chemical binding]; other site 272620007973 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 272620007974 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272620007975 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272620007976 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 272620007977 Probable Catalytic site; other site 272620007978 metal-binding site 272620007979 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272620007980 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 272620007981 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272620007982 NADP binding site [chemical binding]; other site 272620007983 active site 272620007984 putative substrate binding site [chemical binding]; other site 272620007985 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272620007986 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272620007987 substrate binding site; other site 272620007988 tetramer interface; other site 272620007989 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 272620007990 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272620007991 NAD binding site [chemical binding]; other site 272620007992 substrate binding site [chemical binding]; other site 272620007993 homodimer interface [polypeptide binding]; other site 272620007994 active site 272620007995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 272620007996 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 272620007997 putative NAD(P) binding site [chemical binding]; other site 272620007998 active site 272620007999 putative substrate binding site [chemical binding]; other site 272620008000 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 272620008001 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272620008002 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272620008003 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272620008004 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 272620008005 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 272620008006 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 272620008007 NADP binding site [chemical binding]; other site 272620008008 active site 272620008009 putative substrate binding site [chemical binding]; other site 272620008010 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272620008011 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272620008012 substrate binding site; other site 272620008013 tetramer interface; other site 272620008014 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 272620008015 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272620008016 NAD binding site [chemical binding]; other site 272620008017 substrate binding site [chemical binding]; other site 272620008018 homodimer interface [polypeptide binding]; other site 272620008019 active site 272620008020 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272620008021 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 272620008022 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 272620008023 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 272620008024 colanic acid exporter; Provisional; Region: PRK10459 272620008025 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 272620008026 Right handed beta helix region; Region: Beta_helix; pfam13229 272620008027 putative glycosyl transferase; Provisional; Region: PRK10018 272620008028 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272620008029 active site 272620008030 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 272620008031 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 272620008032 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 272620008033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272620008034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272620008035 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272620008036 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 272620008037 active site 272620008038 undecaprenyl-phosphate galactose phosphotransferase; Provisional; Region: PRK15204 272620008039 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272620008040 Bacterial sugar transferase; Region: Bac_transf; pfam02397 272620008041 tyrosine kinase; Provisional; Region: PRK11519 272620008042 Chain length determinant protein; Region: Wzz; pfam02706 272620008043 Chain length determinant protein; Region: Wzz; cl15801 272620008044 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 272620008045 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272620008046 Nucleotide binding site [chemical binding]; other site 272620008047 DTAP/Switch II; other site 272620008048 Switch I; other site 272620008049 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272620008050 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 272620008051 active site 272620008052 polysaccharide export protein Wza; Provisional; Region: PRK15078 272620008053 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 272620008054 SLBB domain; Region: SLBB; pfam10531 272620008055 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 272620008056 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272620008057 Acid phosphatase homologues; Region: acidPPc; smart00014 272620008058 active site 272620008059 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272620008060 active site 272620008061 tetramer interface; other site 272620008062 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 272620008063 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272620008064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272620008065 Transporter associated domain; Region: CorC_HlyC; smart01091 272620008066 putative assembly protein; Provisional; Region: PRK10833 272620008067 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272620008068 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272620008069 trimer interface [polypeptide binding]; other site 272620008070 active site 272620008071 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 272620008072 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272620008073 ATP-binding site [chemical binding]; other site 272620008074 Sugar specificity; other site 272620008075 Pyrimidine base specificity; other site 272620008076 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 272620008077 AlkA N-terminal domain; Region: AlkA_N; pfam06029 272620008078 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272620008079 minor groove reading motif; other site 272620008080 helix-hairpin-helix signature motif; other site 272620008081 substrate binding pocket [chemical binding]; other site 272620008082 active site 272620008083 putative chaperone; Provisional; Region: PRK11678 272620008084 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 272620008085 nucleotide binding site [chemical binding]; other site 272620008086 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272620008087 SBD interface [polypeptide binding]; other site 272620008088 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 272620008089 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 272620008090 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 272620008091 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620008092 dimer interface [polypeptide binding]; other site 272620008093 phosphorylation site [posttranslational modification] 272620008094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620008095 ATP binding site [chemical binding]; other site 272620008096 Mg2+ binding site [ion binding]; other site 272620008097 G-X-G motif; other site 272620008098 transcriptional regulator PhoB; Provisional; Region: PRK10161 272620008099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620008100 active site 272620008101 phosphorylation site [posttranslational modification] 272620008102 intermolecular recognition site; other site 272620008103 dimerization interface [polypeptide binding]; other site 272620008104 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 272620008105 DNA binding site [nucleotide binding] 272620008106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272620008107 DNA binding residues [nucleotide binding] 272620008108 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272620008109 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 272620008110 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 272620008111 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620008112 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620008113 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 272620008114 Protein export membrane protein; Region: SecD_SecF; cl14618 272620008115 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 272620008116 putative transporter; Provisional; Region: PRK10504 272620008117 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008118 putative substrate translocation pore; other site 272620008119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008120 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 272620008121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620008122 dimerization interface [polypeptide binding]; other site 272620008123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620008124 dimer interface [polypeptide binding]; other site 272620008125 phosphorylation site [posttranslational modification] 272620008126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620008127 ATP binding site [chemical binding]; other site 272620008128 Mg2+ binding site [ion binding]; other site 272620008129 G-X-G motif; other site 272620008130 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 272620008131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620008132 active site 272620008133 phosphorylation site [posttranslational modification] 272620008134 intermolecular recognition site; other site 272620008135 dimerization interface [polypeptide binding]; other site 272620008136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620008137 DNA binding site [nucleotide binding] 272620008138 putative protease; Provisional; Region: PRK15452 272620008139 Peptidase family U32; Region: Peptidase_U32; pfam01136 272620008140 lipid kinase; Reviewed; Region: PRK13054 272620008141 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 272620008142 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272620008143 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620008144 Walker A/P-loop; other site 272620008145 ATP binding site [chemical binding]; other site 272620008146 Q-loop/lid; other site 272620008147 ABC transporter signature motif; other site 272620008148 Walker B; other site 272620008149 D-loop; other site 272620008150 H-loop/switch region; other site 272620008151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272620008152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620008153 Walker A/P-loop; other site 272620008154 ATP binding site [chemical binding]; other site 272620008155 Q-loop/lid; other site 272620008156 ABC transporter signature motif; other site 272620008157 Walker B; other site 272620008158 D-loop; other site 272620008159 H-loop/switch region; other site 272620008160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620008161 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272620008162 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620008163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008164 dimer interface [polypeptide binding]; other site 272620008165 conserved gate region; other site 272620008166 ABC-ATPase subunit interface; other site 272620008167 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272620008168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008169 dimer interface [polypeptide binding]; other site 272620008170 conserved gate region; other site 272620008171 putative PBP binding loops; other site 272620008172 ABC-ATPase subunit interface; other site 272620008173 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620008174 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 272620008175 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 272620008176 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 272620008177 putative active site pocket [active] 272620008178 metal binding site [ion binding]; metal-binding site 272620008179 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 272620008180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620008181 motif II; other site 272620008182 polyol permease family; Region: 2A0118; TIGR00897 272620008183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008184 putative substrate translocation pore; other site 272620008185 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272620008186 N- and C-terminal domain interface [polypeptide binding]; other site 272620008187 D-xylulose kinase; Region: XylB; TIGR01312 272620008188 active site 272620008189 MgATP binding site [chemical binding]; other site 272620008190 catalytic site [active] 272620008191 metal binding site [ion binding]; metal-binding site 272620008192 xylulose binding site [chemical binding]; other site 272620008193 homodimer interface [polypeptide binding]; other site 272620008194 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272620008195 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272620008196 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272620008197 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272620008198 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 272620008199 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272620008200 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620008201 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620008202 DNA binding site [nucleotide binding] 272620008203 domain linker motif; other site 272620008204 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 272620008205 dimerization interface [polypeptide binding]; other site 272620008206 ligand binding site [chemical binding]; other site 272620008207 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272620008208 classical (c) SDRs; Region: SDR_c; cd05233 272620008209 NAD(P) binding site [chemical binding]; other site 272620008210 active site 272620008211 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 272620008212 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 272620008213 N- and C-terminal domain interface [polypeptide binding]; other site 272620008214 active site 272620008215 MgATP binding site [chemical binding]; other site 272620008216 catalytic site [active] 272620008217 metal binding site [ion binding]; metal-binding site 272620008218 carbohydrate binding site [chemical binding]; other site 272620008219 putative homodimer interface [polypeptide binding]; other site 272620008220 polyol permease family; Region: 2A0118; TIGR00897 272620008221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008222 putative substrate translocation pore; other site 272620008223 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 272620008224 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 272620008225 putative active site; other site 272620008226 catalytic residue [active] 272620008227 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 272620008228 dimer interface [polypeptide binding]; other site 272620008229 substrate binding site [chemical binding]; other site 272620008230 ATP binding site [chemical binding]; other site 272620008231 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 272620008232 substrate binding site [chemical binding]; other site 272620008233 multimerization interface [polypeptide binding]; other site 272620008234 ATP binding site [chemical binding]; other site 272620008235 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620008236 Ligand Binding Site [chemical binding]; other site 272620008237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620008238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620008240 dimerization interface [polypeptide binding]; other site 272620008241 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 272620008242 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272620008243 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 272620008244 active site 272620008245 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 272620008246 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272620008247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620008248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008249 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620008250 putative effector binding pocket; other site 272620008251 dimerization interface [polypeptide binding]; other site 272620008252 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 272620008253 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620008254 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620008255 Coenzyme A binding pocket [chemical binding]; other site 272620008256 antiporter inner membrane protein; Provisional; Region: PRK11670 272620008257 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 272620008258 Walker A motif; other site 272620008259 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 272620008260 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272620008261 active site 272620008262 HIGH motif; other site 272620008263 KMSKS motif; other site 272620008264 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272620008265 tRNA binding surface [nucleotide binding]; other site 272620008266 anticodon binding site; other site 272620008267 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 272620008268 dimer interface [polypeptide binding]; other site 272620008269 putative tRNA-binding site [nucleotide binding]; other site 272620008270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 272620008271 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 272620008272 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 272620008273 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 272620008274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620008275 active site 272620008276 phosphorylation site [posttranslational modification] 272620008277 intermolecular recognition site; other site 272620008278 dimerization interface [polypeptide binding]; other site 272620008279 LytTr DNA-binding domain; Region: LytTR; pfam04397 272620008280 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 272620008281 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 272620008282 GAF domain; Region: GAF; pfam01590 272620008283 Histidine kinase; Region: His_kinase; pfam06580 272620008284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620008285 ATP binding site [chemical binding]; other site 272620008286 Mg2+ binding site [ion binding]; other site 272620008287 G-X-G motif; other site 272620008288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008289 dimer interface [polypeptide binding]; other site 272620008290 conserved gate region; other site 272620008291 putative PBP binding loops; other site 272620008292 ABC-ATPase subunit interface; other site 272620008293 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 272620008294 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 272620008295 Walker A/P-loop; other site 272620008296 ATP binding site [chemical binding]; other site 272620008297 Q-loop/lid; other site 272620008298 ABC transporter signature motif; other site 272620008299 Walker B; other site 272620008300 D-loop; other site 272620008301 H-loop/switch region; other site 272620008302 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 272620008303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008304 conserved gate region; other site 272620008305 ABC-ATPase subunit interface; other site 272620008306 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272620008307 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 272620008308 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 272620008309 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 272620008310 D-lactate dehydrogenase; Provisional; Region: PRK11183 272620008311 FAD binding domain; Region: FAD_binding_4; pfam01565 272620008312 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 272620008313 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272620008314 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620008315 Coenzyme A binding pocket [chemical binding]; other site 272620008316 putative transposase OrfB; Reviewed; Region: PHA02517 272620008317 HTH-like domain; Region: HTH_21; pfam13276 272620008318 Integrase core domain; Region: rve; pfam00665 272620008319 Integrase core domain; Region: rve_2; pfam13333 272620008320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620008321 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620008322 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620008323 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 272620008324 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 272620008325 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 272620008326 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272620008327 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272620008328 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 272620008329 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 272620008330 beta-galactosidase; Region: BGL; TIGR03356 272620008331 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 272620008332 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620008333 active site turn [active] 272620008334 phosphorylation site [posttranslational modification] 272620008335 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620008336 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272620008337 HPr interaction site; other site 272620008338 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272620008339 active site 272620008340 phosphorylation site [posttranslational modification] 272620008341 transcriptional antiterminator BglG; Provisional; Region: PRK09772 272620008342 CAT RNA binding domain; Region: CAT_RBD; smart01061 272620008343 PRD domain; Region: PRD; pfam00874 272620008344 PRD domain; Region: PRD; pfam00874 272620008345 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 272620008346 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 272620008347 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272620008348 FMN binding site [chemical binding]; other site 272620008349 active site 272620008350 catalytic residues [active] 272620008351 substrate binding site [chemical binding]; other site 272620008352 hypothetical protein; Provisional; Region: PRK01821 272620008353 hypothetical protein; Provisional; Region: PRK10711 272620008354 cytidine deaminase; Provisional; Region: PRK09027 272620008355 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272620008356 active site 272620008357 catalytic motif [active] 272620008358 Zn binding site [ion binding]; other site 272620008359 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272620008360 active site 272620008361 catalytic motif [active] 272620008362 Zn binding site [ion binding]; other site 272620008363 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 272620008364 putative active site [active] 272620008365 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620008366 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620008367 TM-ABC transporter signature motif; other site 272620008368 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 272620008369 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620008370 Walker A/P-loop; other site 272620008371 ATP binding site [chemical binding]; other site 272620008372 Q-loop/lid; other site 272620008373 ABC transporter signature motif; other site 272620008374 Walker B; other site 272620008375 D-loop; other site 272620008376 H-loop/switch region; other site 272620008377 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620008378 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 272620008379 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 272620008380 ligand binding site [chemical binding]; other site 272620008381 calcium binding site [ion binding]; other site 272620008382 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 272620008383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620008384 DNA binding site [nucleotide binding] 272620008385 domain linker motif; other site 272620008386 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 272620008387 dimerization interface (closed form) [polypeptide binding]; other site 272620008388 ligand binding site [chemical binding]; other site 272620008389 Predicted membrane protein [Function unknown]; Region: COG2311 272620008390 hypothetical protein; Provisional; Region: PRK10835 272620008391 GTP cyclohydrolase I; Provisional; Region: PLN03044 272620008392 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272620008393 active site 272620008394 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 272620008395 S-formylglutathione hydrolase; Region: PLN02442 272620008396 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 272620008397 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620008398 N-terminal plug; other site 272620008399 ligand-binding site [chemical binding]; other site 272620008400 lysine transporter; Provisional; Region: PRK10836 272620008401 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 272620008402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008403 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 272620008404 putative dimerization interface [polypeptide binding]; other site 272620008405 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 272620008406 endonuclease IV; Provisional; Region: PRK01060 272620008407 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272620008408 DNA interaction; other site 272620008409 Metal-binding active site; metal-binding site 272620008410 AP (apurinic/apyrimidinic) site pocket; other site 272620008411 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 272620008412 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 272620008413 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272620008414 active site 272620008415 P-loop; other site 272620008416 phosphorylation site [posttranslational modification] 272620008417 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 272620008418 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272620008419 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272620008420 putative substrate binding site [chemical binding]; other site 272620008421 putative ATP binding site [chemical binding]; other site 272620008422 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 272620008423 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620008424 active site 272620008425 phosphorylation site [posttranslational modification] 272620008426 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272620008427 dimerization domain swap beta strand [polypeptide binding]; other site 272620008428 regulatory protein interface [polypeptide binding]; other site 272620008429 active site 272620008430 regulatory phosphorylation site [posttranslational modification]; other site 272620008431 sugar efflux transporter B; Provisional; Region: PRK15011 272620008432 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008433 putative substrate translocation pore; other site 272620008434 elongation factor P; Provisional; Region: PRK04542 272620008435 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272620008436 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272620008437 RNA binding site [nucleotide binding]; other site 272620008438 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272620008439 RNA binding site [nucleotide binding]; other site 272620008440 mannonate dehydratase; Provisional; Region: PRK03906 272620008441 mannonate dehydratase; Region: uxuA; TIGR00695 272620008442 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 272620008443 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272620008444 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272620008445 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 272620008446 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 272620008447 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 272620008448 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272620008449 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272620008450 active site 272620008451 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 272620008452 NlpC/P60 family; Region: NLPC_P60; pfam00877 272620008453 phage resistance protein; Provisional; Region: PRK10551 272620008454 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620008455 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620008456 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 272620008457 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 272620008458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 272620008459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008460 dimer interface [polypeptide binding]; other site 272620008461 conserved gate region; other site 272620008462 putative PBP binding loops; other site 272620008463 ABC-ATPase subunit interface; other site 272620008464 microcin C ABC transporter permease; Provisional; Region: PRK15021 272620008465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008466 dimer interface [polypeptide binding]; other site 272620008467 conserved gate region; other site 272620008468 ABC-ATPase subunit interface; other site 272620008469 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 272620008470 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620008471 Walker A/P-loop; other site 272620008472 ATP binding site [chemical binding]; other site 272620008473 Q-loop/lid; other site 272620008474 ABC transporter signature motif; other site 272620008475 Walker B; other site 272620008476 D-loop; other site 272620008477 H-loop/switch region; other site 272620008478 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620008479 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620008480 Walker A/P-loop; other site 272620008481 ATP binding site [chemical binding]; other site 272620008482 Q-loop/lid; other site 272620008483 ABC transporter signature motif; other site 272620008484 Walker B; other site 272620008485 D-loop; other site 272620008486 H-loop/switch region; other site 272620008487 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620008488 hypothetical protein; Provisional; Region: PRK11835 272620008489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008490 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 272620008491 putative substrate translocation pore; other site 272620008492 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 272620008493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620008494 RNA binding surface [nucleotide binding]; other site 272620008495 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 272620008496 active site 272620008497 uracil binding [chemical binding]; other site 272620008498 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 272620008499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620008500 ATP binding site [chemical binding]; other site 272620008501 putative Mg++ binding site [ion binding]; other site 272620008502 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620008503 nucleotide binding region [chemical binding]; other site 272620008504 ATP-binding site [chemical binding]; other site 272620008505 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 272620008506 5S rRNA interface [nucleotide binding]; other site 272620008507 CTC domain interface [polypeptide binding]; other site 272620008508 L16 interface [polypeptide binding]; other site 272620008509 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620008510 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008511 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620008512 dimerization interface [polypeptide binding]; other site 272620008513 Beta-lactamase; Region: Beta-lactamase; pfam00144 272620008514 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 272620008515 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 272620008516 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272620008517 dimer interface [polypeptide binding]; other site 272620008518 ADP-ribose binding site [chemical binding]; other site 272620008519 active site 272620008520 nudix motif; other site 272620008521 metal binding site [ion binding]; metal-binding site 272620008522 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620008523 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620008524 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620008525 Nucleoid-associated protein [General function prediction only]; Region: COG3081 272620008526 nucleoid-associated protein NdpA; Validated; Region: PRK00378 272620008527 hypothetical protein; Provisional; Region: PRK13689 272620008528 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 272620008529 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 272620008530 Sulfatase; Region: Sulfatase; cl17466 272620008531 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272620008532 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272620008533 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 272620008534 secondary substrate binding site; other site 272620008535 primary substrate binding site; other site 272620008536 inhibition loop; other site 272620008537 dimerization interface [polypeptide binding]; other site 272620008538 malate:quinone oxidoreductase; Validated; Region: PRK05257 272620008539 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 272620008540 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272620008541 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272620008542 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272620008543 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272620008544 MgtE intracellular N domain; Region: MgtE_N; smart00924 272620008545 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272620008546 Divalent cation transporter; Region: MgtE; cl00786 272620008547 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 272620008548 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272620008549 Walker A/P-loop; other site 272620008550 ATP binding site [chemical binding]; other site 272620008551 Q-loop/lid; other site 272620008552 ABC transporter signature motif; other site 272620008553 Walker B; other site 272620008554 D-loop; other site 272620008555 H-loop/switch region; other site 272620008556 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 272620008557 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 272620008558 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272620008559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620008560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620008561 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 272620008562 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272620008563 DNA binding site [nucleotide binding] 272620008564 active site 272620008565 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 272620008566 ApbE family; Region: ApbE; pfam02424 272620008567 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 272620008568 outer membrane porin protein C; Provisional; Region: PRK10554 272620008569 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 272620008570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620008571 ATP binding site [chemical binding]; other site 272620008572 Mg2+ binding site [ion binding]; other site 272620008573 G-X-G motif; other site 272620008574 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272620008575 putative binding surface; other site 272620008576 active site 272620008577 transcriptional regulator RcsB; Provisional; Region: PRK10840 272620008578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620008579 active site 272620008580 phosphorylation site [posttranslational modification] 272620008581 intermolecular recognition site; other site 272620008582 dimerization interface [polypeptide binding]; other site 272620008583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620008584 DNA binding residues [nucleotide binding] 272620008585 dimerization interface [polypeptide binding]; other site 272620008586 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 272620008587 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620008588 dimer interface [polypeptide binding]; other site 272620008589 phosphorylation site [posttranslational modification] 272620008590 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620008591 ATP binding site [chemical binding]; other site 272620008592 Mg2+ binding site [ion binding]; other site 272620008593 G-X-G motif; other site 272620008594 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 272620008595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620008596 active site 272620008597 phosphorylation site [posttranslational modification] 272620008598 intermolecular recognition site; other site 272620008599 dimerization interface [polypeptide binding]; other site 272620008600 DNA gyrase subunit A; Validated; Region: PRK05560 272620008601 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272620008602 CAP-like domain; other site 272620008603 active site 272620008604 primary dimer interface [polypeptide binding]; other site 272620008605 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272620008606 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272620008607 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272620008608 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272620008609 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272620008610 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272620008611 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 272620008612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620008613 S-adenosylmethionine binding site [chemical binding]; other site 272620008614 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 272620008615 ATP cone domain; Region: ATP-cone; pfam03477 272620008616 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272620008617 active site 272620008618 dimer interface [polypeptide binding]; other site 272620008619 catalytic residues [active] 272620008620 effector binding site; other site 272620008621 R2 peptide binding site; other site 272620008622 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272620008623 dimer interface [polypeptide binding]; other site 272620008624 putative radical transfer pathway; other site 272620008625 diiron center [ion binding]; other site 272620008626 tyrosyl radical; other site 272620008627 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272620008628 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620008629 catalytic loop [active] 272620008630 iron binding site [ion binding]; other site 272620008631 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 272620008632 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 272620008633 active site 272620008634 catalytic site [active] 272620008635 metal binding site [ion binding]; metal-binding site 272620008636 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 272620008637 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008638 putative substrate translocation pore; other site 272620008639 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 272620008640 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272620008641 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272620008642 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 272620008643 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 272620008644 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 272620008645 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272620008646 Cysteine-rich domain; Region: CCG; pfam02754 272620008647 Cysteine-rich domain; Region: CCG; pfam02754 272620008648 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 272620008649 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 272620008650 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008651 putative substrate translocation pore; other site 272620008652 L-rhamnonate dehydratase; Provisional; Region: PRK15440 272620008653 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 272620008654 putative active site pocket [active] 272620008655 putative metal binding site [ion binding]; other site 272620008656 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620008657 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272620008658 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620008659 hypothetical protein; Provisional; Region: PRK03673 272620008660 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 272620008661 putative MPT binding site; other site 272620008662 Competence-damaged protein; Region: CinA; cl00666 272620008663 YfaZ precursor; Region: YfaZ; pfam07437 272620008664 Organic solvent tolerance protein; Region: OstA_C; pfam04453 272620008665 putative transposase; Provisional; Region: PRK09857 272620008666 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620008667 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 272620008668 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 272620008669 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 272620008670 acyl-activating enzyme (AAE) consensus motif; other site 272620008671 putative AMP binding site [chemical binding]; other site 272620008672 putative active site [active] 272620008673 putative CoA binding site [chemical binding]; other site 272620008674 O-succinylbenzoate synthase; Provisional; Region: PRK05105 272620008675 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 272620008676 active site 272620008677 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272620008678 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 272620008679 substrate binding site [chemical binding]; other site 272620008680 oxyanion hole (OAH) forming residues; other site 272620008681 trimer interface [polypeptide binding]; other site 272620008682 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 272620008683 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 272620008684 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 272620008685 dimer interface [polypeptide binding]; other site 272620008686 tetramer interface [polypeptide binding]; other site 272620008687 PYR/PP interface [polypeptide binding]; other site 272620008688 TPP binding site [chemical binding]; other site 272620008689 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 272620008690 TPP-binding site; other site 272620008691 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 272620008692 chorismate binding enzyme; Region: Chorismate_bind; cl10555 272620008693 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272620008694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620008695 Coenzyme A binding pocket [chemical binding]; other site 272620008696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272620008697 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 272620008698 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272620008699 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 272620008700 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272620008701 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 272620008702 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 272620008703 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272620008704 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 272620008705 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 272620008706 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 272620008707 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 272620008708 4Fe-4S binding domain; Region: Fer4; pfam00037 272620008709 4Fe-4S binding domain; Region: Fer4; pfam00037 272620008710 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 272620008711 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 272620008712 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620008713 catalytic loop [active] 272620008714 iron binding site [ion binding]; other site 272620008715 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 272620008716 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 272620008717 [4Fe-4S] binding site [ion binding]; other site 272620008718 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 272620008719 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 272620008720 SLBB domain; Region: SLBB; pfam10531 272620008721 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 272620008722 NADH dehydrogenase subunit E; Validated; Region: PRK07539 272620008723 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 272620008724 putative dimer interface [polypeptide binding]; other site 272620008725 [2Fe-2S] cluster binding site [ion binding]; other site 272620008726 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 272620008727 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 272620008728 NADH dehydrogenase subunit D; Validated; Region: PRK06075 272620008729 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 272620008730 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 272620008731 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 272620008732 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008733 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 272620008734 putative dimerization interface [polypeptide binding]; other site 272620008735 aminotransferase AlaT; Validated; Region: PRK09265 272620008736 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620008737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620008738 homodimer interface [polypeptide binding]; other site 272620008739 catalytic residue [active] 272620008740 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620008741 Zn2+ binding site [ion binding]; other site 272620008742 Mg2+ binding site [ion binding]; other site 272620008743 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 272620008744 transmembrane helices; other site 272620008745 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272620008746 TrkA-C domain; Region: TrkA_C; pfam02080 272620008747 TrkA-C domain; Region: TrkA_C; pfam02080 272620008748 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272620008749 putative phosphatase; Provisional; Region: PRK11587 272620008750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620008751 motif II; other site 272620008752 hypothetical protein; Validated; Region: PRK05445 272620008753 YfbU domain; Region: YfbU; cl01137 272620008754 hypothetical protein; Provisional; Region: PRK01816 272620008755 propionate/acetate kinase; Provisional; Region: PRK12379 272620008756 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272620008757 phosphate acetyltransferase; Reviewed; Region: PRK05632 272620008758 DRTGG domain; Region: DRTGG; pfam07085 272620008759 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 272620008760 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 272620008761 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 272620008762 nudix motif; other site 272620008763 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272620008764 active site 272620008765 metal binding site [ion binding]; metal-binding site 272620008766 homotetramer interface [polypeptide binding]; other site 272620008767 glutathione S-transferase; Provisional; Region: PRK15113 272620008768 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 272620008769 C-terminal domain interface [polypeptide binding]; other site 272620008770 GSH binding site (G-site) [chemical binding]; other site 272620008771 dimer interface [polypeptide binding]; other site 272620008772 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 272620008773 N-terminal domain interface [polypeptide binding]; other site 272620008774 putative dimer interface [polypeptide binding]; other site 272620008775 putative substrate binding pocket (H-site) [chemical binding]; other site 272620008776 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 272620008777 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272620008778 C-terminal domain interface [polypeptide binding]; other site 272620008779 GSH binding site (G-site) [chemical binding]; other site 272620008780 dimer interface [polypeptide binding]; other site 272620008781 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 272620008782 N-terminal domain interface [polypeptide binding]; other site 272620008783 putative dimer interface [polypeptide binding]; other site 272620008784 active site 272620008785 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272620008786 homooctamer interface [polypeptide binding]; other site 272620008787 active site 272620008788 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 272620008789 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 272620008790 putative NAD(P) binding site [chemical binding]; other site 272620008791 putative active site [active] 272620008792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272620008793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620008794 Coenzyme A binding pocket [chemical binding]; other site 272620008795 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 272620008796 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620008797 Walker A/P-loop; other site 272620008798 ATP binding site [chemical binding]; other site 272620008799 Q-loop/lid; other site 272620008800 ABC transporter signature motif; other site 272620008801 Walker B; other site 272620008802 D-loop; other site 272620008803 H-loop/switch region; other site 272620008804 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620008805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008806 dimer interface [polypeptide binding]; other site 272620008807 conserved gate region; other site 272620008808 putative PBP binding loops; other site 272620008809 ABC-ATPase subunit interface; other site 272620008810 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 272620008811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620008812 dimer interface [polypeptide binding]; other site 272620008813 conserved gate region; other site 272620008814 putative PBP binding loops; other site 272620008815 ABC-ATPase subunit interface; other site 272620008816 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 272620008817 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620008818 substrate binding pocket [chemical binding]; other site 272620008819 membrane-bound complex binding site; other site 272620008820 hinge residues; other site 272620008821 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 272620008822 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620008823 substrate binding pocket [chemical binding]; other site 272620008824 membrane-bound complex binding site; other site 272620008825 hinge residues; other site 272620008826 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 272620008827 Flavoprotein; Region: Flavoprotein; pfam02441 272620008828 amidophosphoribosyltransferase; Provisional; Region: PRK09246 272620008829 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 272620008830 active site 272620008831 tetramer interface [polypeptide binding]; other site 272620008832 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620008833 active site 272620008834 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 272620008835 colicin V production protein; Provisional; Region: PRK10845 272620008836 cell division protein DedD; Provisional; Region: PRK11633 272620008837 Sporulation related domain; Region: SPOR; pfam05036 272620008838 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 272620008839 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272620008840 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272620008841 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 272620008842 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 272620008843 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272620008844 hypothetical protein; Provisional; Region: PRK10847 272620008845 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272620008846 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272620008847 dimerization interface 3.5A [polypeptide binding]; other site 272620008848 active site 272620008849 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 272620008850 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272620008851 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 272620008852 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 272620008853 ligand binding site [chemical binding]; other site 272620008854 NAD binding site [chemical binding]; other site 272620008855 catalytic site [active] 272620008856 homodimer interface [polypeptide binding]; other site 272620008857 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 272620008858 putative transporter; Provisional; Region: PRK12382 272620008859 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 272620008860 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 272620008861 dimer interface [polypeptide binding]; other site 272620008862 active site 272620008863 Uncharacterized conserved protein [Function unknown]; Region: COG4121 272620008864 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 272620008865 YfcL protein; Region: YfcL; pfam08891 272620008866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 272620008867 hypothetical protein; Provisional; Region: PRK10621 272620008868 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 272620008869 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 272620008870 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 272620008871 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 272620008872 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 272620008873 Tetramer interface [polypeptide binding]; other site 272620008874 active site 272620008875 FMN-binding site [chemical binding]; other site 272620008876 HemK family putative methylases; Region: hemK_fam; TIGR00536 272620008877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620008878 S-adenosylmethionine binding site [chemical binding]; other site 272620008879 hypothetical protein; Provisional; Region: PRK04946 272620008880 Smr domain; Region: Smr; pfam01713 272620008881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272620008882 catalytic core [active] 272620008883 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 272620008884 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272620008885 substrate binding site [chemical binding]; other site 272620008886 oxyanion hole (OAH) forming residues; other site 272620008887 trimer interface [polypeptide binding]; other site 272620008888 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272620008889 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620008890 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620008891 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 272620008892 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620008893 dimer interface [polypeptide binding]; other site 272620008894 active site 272620008895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 272620008896 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 272620008897 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 272620008898 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 272620008899 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 272620008900 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 272620008901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620008903 dimerization interface [polypeptide binding]; other site 272620008904 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272620008905 nucleoside/Zn binding site; other site 272620008906 dimer interface [polypeptide binding]; other site 272620008907 catalytic motif [active] 272620008908 putative cyanate transporter; Provisional; Region: cynX; PRK09705 272620008909 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620008910 aminotransferase; Validated; Region: PRK08175 272620008911 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620008912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620008913 homodimer interface [polypeptide binding]; other site 272620008914 catalytic residue [active] 272620008915 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 272620008916 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 272620008917 Histidine kinase; Region: His_kinase; pfam06580 272620008918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620008919 ATP binding site [chemical binding]; other site 272620008920 Mg2+ binding site [ion binding]; other site 272620008921 G-X-G motif; other site 272620008922 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 272620008923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620008924 active site 272620008925 phosphorylation site [posttranslational modification] 272620008926 intermolecular recognition site; other site 272620008927 dimerization interface [polypeptide binding]; other site 272620008928 LytTr DNA-binding domain; Region: LytTR; pfam04397 272620008929 glucokinase; Provisional; Region: glk; PRK00292 272620008930 glucokinase, proteobacterial type; Region: glk; TIGR00749 272620008931 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272620008932 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 272620008933 Cl- selectivity filter; other site 272620008934 Cl- binding residues [ion binding]; other site 272620008935 pore gating glutamate residue; other site 272620008936 dimer interface [polypeptide binding]; other site 272620008937 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 272620008938 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272620008939 dimer interface [polypeptide binding]; other site 272620008940 PYR/PP interface [polypeptide binding]; other site 272620008941 TPP binding site [chemical binding]; other site 272620008942 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620008943 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 272620008944 TPP-binding site [chemical binding]; other site 272620008945 dimer interface [polypeptide binding]; other site 272620008946 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620008947 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620008948 active site 272620008949 catalytic tetrad [active] 272620008950 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 272620008951 manganese transport protein MntH; Reviewed; Region: PRK00701 272620008952 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 272620008953 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 272620008954 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 272620008955 Nucleoside recognition; Region: Gate; pfam07670 272620008956 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 272620008957 MASE1; Region: MASE1; pfam05231 272620008958 diguanylate cyclase; Region: GGDEF; smart00267 272620008959 metal binding site [ion binding]; metal-binding site 272620008960 nucleotidyl binding site; other site 272620008961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620008962 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 272620008963 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 272620008964 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272620008965 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272620008966 active site 272620008967 HIGH motif; other site 272620008968 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272620008969 active site 272620008970 KMSKS motif; other site 272620008971 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620008972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620008973 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 272620008974 putative dimerization interface [polypeptide binding]; other site 272620008975 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272620008976 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 272620008977 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 272620008978 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272620008979 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272620008980 nucleotide binding pocket [chemical binding]; other site 272620008981 K-X-D-G motif; other site 272620008982 catalytic site [active] 272620008983 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272620008984 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272620008985 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272620008986 Dimer interface [polypeptide binding]; other site 272620008987 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 272620008988 cell division protein ZipA; Provisional; Region: PRK03427 272620008989 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 272620008990 FtsZ protein binding site [polypeptide binding]; other site 272620008991 putative sulfate transport protein CysZ; Validated; Region: PRK04949 272620008992 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272620008993 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272620008994 dimer interface [polypeptide binding]; other site 272620008995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620008996 catalytic residue [active] 272620008997 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272620008998 dimerization domain swap beta strand [polypeptide binding]; other site 272620008999 regulatory protein interface [polypeptide binding]; other site 272620009000 active site 272620009001 regulatory phosphorylation site [posttranslational modification]; other site 272620009002 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 272620009003 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272620009004 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272620009005 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272620009006 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 272620009007 HPr interaction site; other site 272620009008 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272620009009 active site 272620009010 phosphorylation site [posttranslational modification] 272620009011 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 272620009012 dimer interface [polypeptide binding]; other site 272620009013 pyridoxamine kinase; Validated; Region: PRK05756 272620009014 pyridoxal binding site [chemical binding]; other site 272620009015 ATP binding site [chemical binding]; other site 272620009016 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 272620009017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620009018 DNA-binding site [nucleotide binding]; DNA binding site 272620009019 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620009020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620009021 homodimer interface [polypeptide binding]; other site 272620009022 catalytic residue [active] 272620009023 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 272620009024 cysteine synthase B; Region: cysM; TIGR01138 272620009025 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272620009026 dimer interface [polypeptide binding]; other site 272620009027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620009028 catalytic residue [active] 272620009029 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 272620009030 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 272620009031 Walker A/P-loop; other site 272620009032 ATP binding site [chemical binding]; other site 272620009033 Q-loop/lid; other site 272620009034 ABC transporter signature motif; other site 272620009035 Walker B; other site 272620009036 D-loop; other site 272620009037 H-loop/switch region; other site 272620009038 TOBE-like domain; Region: TOBE_3; pfam12857 272620009039 sulfate transport protein; Provisional; Region: cysT; CHL00187 272620009040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620009041 dimer interface [polypeptide binding]; other site 272620009042 conserved gate region; other site 272620009043 putative PBP binding loops; other site 272620009044 ABC-ATPase subunit interface; other site 272620009045 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272620009046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620009047 dimer interface [polypeptide binding]; other site 272620009048 conserved gate region; other site 272620009049 putative PBP binding loops; other site 272620009050 ABC-ATPase subunit interface; other site 272620009051 thiosulfate transporter subunit; Provisional; Region: PRK10852 272620009052 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272620009053 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 272620009054 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 272620009055 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 272620009056 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 272620009057 putative acetyltransferase; Provisional; Region: PRK03624 272620009058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620009059 Coenzyme A binding pocket [chemical binding]; other site 272620009060 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 272620009061 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272620009062 active site 272620009063 metal binding site [ion binding]; metal-binding site 272620009064 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 272620009065 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 272620009066 transcriptional regulator EutR; Provisional; Region: PRK10130 272620009067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620009068 carboxysome structural protein EutK; Provisional; Region: PRK15466 272620009069 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 272620009070 Hexamer interface [polypeptide binding]; other site 272620009071 Hexagonal pore residue; other site 272620009072 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 272620009073 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 272620009074 putative hexamer interface [polypeptide binding]; other site 272620009075 putative hexagonal pore; other site 272620009076 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 272620009077 putative hexamer interface [polypeptide binding]; other site 272620009078 putative hexagonal pore; other site 272620009079 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 272620009080 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 272620009081 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 272620009082 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 272620009083 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 272620009084 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 272620009085 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 272620009086 active site 272620009087 metal binding site [ion binding]; metal-binding site 272620009088 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 272620009089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620009090 nucleotide binding site [chemical binding]; other site 272620009091 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 272620009092 NAD(P) binding site [chemical binding]; other site 272620009093 catalytic residues [active] 272620009094 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 272620009095 Hexamer/Pentamer interface [polypeptide binding]; other site 272620009096 central pore; other site 272620009097 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272620009098 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 272620009099 Hexamer interface [polypeptide binding]; other site 272620009100 Hexagonal pore residue; other site 272620009101 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272620009102 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 272620009103 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 272620009104 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 272620009105 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 272620009106 G1 box; other site 272620009107 GTP/Mg2+ binding site [chemical binding]; other site 272620009108 G2 box; other site 272620009109 Switch I region; other site 272620009110 G3 box; other site 272620009111 Switch II region; other site 272620009112 G4 box; other site 272620009113 G5 box; other site 272620009114 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 272620009115 putative hexamer interface [polypeptide binding]; other site 272620009116 putative hexagonal pore; other site 272620009117 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 272620009118 Malic enzyme, N-terminal domain; Region: malic; pfam00390 272620009119 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 272620009120 putative NAD(P) binding site [chemical binding]; other site 272620009121 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 272620009122 transaldolase-like protein; Provisional; Region: PTZ00411 272620009123 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 272620009124 active site 272620009125 dimer interface [polypeptide binding]; other site 272620009126 catalytic residue [active] 272620009127 transketolase; Reviewed; Region: PRK12753 272620009128 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272620009129 TPP-binding site [chemical binding]; other site 272620009130 dimer interface [polypeptide binding]; other site 272620009131 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272620009132 PYR/PP interface [polypeptide binding]; other site 272620009133 dimer interface [polypeptide binding]; other site 272620009134 TPP binding site [chemical binding]; other site 272620009135 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272620009136 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 272620009137 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 272620009138 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272620009139 dimer interface [polypeptide binding]; other site 272620009140 ADP-ribose binding site [chemical binding]; other site 272620009141 active site 272620009142 nudix motif; other site 272620009143 metal binding site [ion binding]; metal-binding site 272620009144 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 272620009145 4Fe-4S binding domain; Region: Fer4; pfam00037 272620009146 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620009147 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620009148 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 272620009149 Protein export membrane protein; Region: SecD_SecF; cl14618 272620009150 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 272620009151 ArsC family; Region: ArsC; pfam03960 272620009152 putative catalytic residues [active] 272620009153 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 272620009154 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 272620009155 metal binding site [ion binding]; metal-binding site 272620009156 dimer interface [polypeptide binding]; other site 272620009157 hypothetical protein; Provisional; Region: PRK13664 272620009158 putative hydrolase; Provisional; Region: PRK11460 272620009159 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 272620009160 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 272620009161 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 272620009162 Helicase; Region: Helicase_RecD; pfam05127 272620009163 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 272620009164 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 272620009165 Predicted metalloprotease [General function prediction only]; Region: COG2321 272620009166 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 272620009167 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 272620009168 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 272620009169 ATP binding site [chemical binding]; other site 272620009170 active site 272620009171 substrate binding site [chemical binding]; other site 272620009172 lipoprotein; Provisional; Region: PRK11679 272620009173 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 272620009174 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 272620009175 dihydrodipicolinate synthase; Region: dapA; TIGR00674 272620009176 dimer interface [polypeptide binding]; other site 272620009177 active site 272620009178 catalytic residue [active] 272620009179 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 272620009180 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 272620009181 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 272620009182 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272620009183 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272620009184 catalytic triad [active] 272620009185 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 272620009186 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272620009187 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 272620009188 Peptidase family M48; Region: Peptidase_M48; cl12018 272620009189 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272620009190 ArsC family; Region: ArsC; pfam03960 272620009191 catalytic residues [active] 272620009192 hypothetical protein; Provisional; Region: PRK09956 272620009193 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620009194 DNA replication initiation factor; Provisional; Region: PRK08084 272620009195 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272620009196 uracil transporter; Provisional; Region: PRK10720 272620009197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620009198 active site 272620009199 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 272620009200 beta-galactosidase; Region: BGL; TIGR03356 272620009201 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272620009202 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620009203 nucleotide binding site [chemical binding]; other site 272620009204 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 272620009205 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 272620009206 dimerization interface [polypeptide binding]; other site 272620009207 putative ATP binding site [chemical binding]; other site 272620009208 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 272620009209 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 272620009210 active site 272620009211 substrate binding site [chemical binding]; other site 272620009212 cosubstrate binding site; other site 272620009213 catalytic site [active] 272620009214 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 272620009215 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 272620009216 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 272620009217 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 272620009218 domain interface [polypeptide binding]; other site 272620009219 active site 272620009220 catalytic site [active] 272620009221 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 272620009222 domain interface [polypeptide binding]; other site 272620009223 active site 272620009224 catalytic site [active] 272620009225 exopolyphosphatase; Provisional; Region: PRK10854 272620009226 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272620009227 MASE1; Region: MASE1; pfam05231 272620009228 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620009229 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 272620009230 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620009231 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620009232 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620009233 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620009234 dimerization interface [polypeptide binding]; other site 272620009235 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 272620009236 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 272620009237 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 272620009238 Sulfatase; Region: Sulfatase; cl17466 272620009239 Sulfatase; Region: Sulfatase; cl17466 272620009240 GMP synthase; Reviewed; Region: guaA; PRK00074 272620009241 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272620009242 AMP/PPi binding site [chemical binding]; other site 272620009243 candidate oxyanion hole; other site 272620009244 catalytic triad [active] 272620009245 potential glutamine specificity residues [chemical binding]; other site 272620009246 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272620009247 ATP Binding subdomain [chemical binding]; other site 272620009248 Ligand Binding sites [chemical binding]; other site 272620009249 Dimerization subdomain; other site 272620009250 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272620009251 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272620009252 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 272620009253 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272620009254 active site 272620009255 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272620009256 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272620009257 generic binding surface II; other site 272620009258 generic binding surface I; other site 272620009259 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620009260 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620009261 Variant-specific surface protein (VSP); Provisional; Region: PTZ00382 272620009262 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 272620009263 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272620009264 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 272620009265 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 272620009266 GTP-binding protein Der; Reviewed; Region: PRK00093 272620009267 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272620009268 G1 box; other site 272620009269 GTP/Mg2+ binding site [chemical binding]; other site 272620009270 Switch I region; other site 272620009271 G2 box; other site 272620009272 Switch II region; other site 272620009273 G3 box; other site 272620009274 G4 box; other site 272620009275 G5 box; other site 272620009276 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272620009277 G1 box; other site 272620009278 GTP/Mg2+ binding site [chemical binding]; other site 272620009279 Switch I region; other site 272620009280 G2 box; other site 272620009281 G3 box; other site 272620009282 Switch II region; other site 272620009283 G4 box; other site 272620009284 G5 box; other site 272620009285 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 272620009286 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 272620009287 Trp docking motif [polypeptide binding]; other site 272620009288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 272620009289 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 272620009290 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 272620009291 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272620009292 dimer interface [polypeptide binding]; other site 272620009293 motif 1; other site 272620009294 active site 272620009295 motif 2; other site 272620009296 motif 3; other site 272620009297 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272620009298 anticodon binding site; other site 272620009299 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272620009300 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272620009301 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272620009302 cytoskeletal protein RodZ; Provisional; Region: PRK10856 272620009303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620009304 non-specific DNA binding site [nucleotide binding]; other site 272620009305 salt bridge; other site 272620009306 sequence-specific DNA binding site [nucleotide binding]; other site 272620009307 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 272620009308 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 272620009309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620009310 FeS/SAM binding site; other site 272620009311 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 272620009312 active site 272620009313 multimer interface [polypeptide binding]; other site 272620009314 penicillin-binding protein 1C; Provisional; Region: PRK11240 272620009315 Transglycosylase; Region: Transgly; pfam00912 272620009316 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272620009317 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 272620009318 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 272620009319 MG2 domain; Region: A2M_N; pfam01835 272620009320 Alpha-2-macroglobulin family; Region: A2M; pfam00207 272620009321 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 272620009322 surface patch; other site 272620009323 thioester region; other site 272620009324 specificity defining residues; other site 272620009325 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 272620009326 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 272620009327 active site residue [active] 272620009328 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 272620009329 active site residue [active] 272620009330 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 272620009331 aminopeptidase B; Provisional; Region: PRK05015 272620009332 Peptidase; Region: DUF3663; pfam12404 272620009333 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272620009334 interface (dimer of trimers) [polypeptide binding]; other site 272620009335 Substrate-binding/catalytic site; other site 272620009336 Zn-binding sites [ion binding]; other site 272620009337 hypothetical protein; Provisional; Region: PRK10721 272620009338 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 272620009339 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 272620009340 catalytic loop [active] 272620009341 iron binding site [ion binding]; other site 272620009342 chaperone protein HscA; Provisional; Region: hscA; PRK05183 272620009343 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 272620009344 nucleotide binding site [chemical binding]; other site 272620009345 putative NEF/HSP70 interaction site [polypeptide binding]; other site 272620009346 SBD interface [polypeptide binding]; other site 272620009347 co-chaperone HscB; Provisional; Region: hscB; PRK05014 272620009348 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272620009349 HSP70 interaction site [polypeptide binding]; other site 272620009350 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 272620009351 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 272620009352 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272620009353 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272620009354 trimerization site [polypeptide binding]; other site 272620009355 active site 272620009356 cysteine desulfurase; Provisional; Region: PRK14012 272620009357 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 272620009358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620009359 catalytic residue [active] 272620009360 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 272620009361 Rrf2 family protein; Region: rrf2_super; TIGR00738 272620009362 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 272620009363 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 272620009364 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272620009365 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 272620009366 active site 272620009367 dimerization interface [polypeptide binding]; other site 272620009368 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 272620009369 Protein of unknown function (DUF1007); Region: DUF1007; pfam06226 272620009370 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 272620009371 PRD domain; Region: PRD; pfam00874 272620009372 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 272620009373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620009374 putative substrate translocation pore; other site 272620009375 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 272620009376 active site 272620009377 catalytic residues [active] 272620009378 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 272620009379 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620009380 putative substrate translocation pore; other site 272620009381 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620009382 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 272620009383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620009384 binding surface 272620009385 TPR motif; other site 272620009386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620009387 binding surface 272620009388 TPR motif; other site 272620009389 TPR repeat; Region: TPR_11; pfam13414 272620009390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620009391 binding surface 272620009392 TPR motif; other site 272620009393 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 272620009394 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272620009395 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620009396 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272620009397 Predicted membrane protein [Function unknown]; Region: COG2259 272620009398 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272620009399 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272620009400 dimer interface [polypeptide binding]; other site 272620009401 active site 272620009402 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272620009403 folate binding site [chemical binding]; other site 272620009404 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 272620009405 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 272620009406 heme-binding site [chemical binding]; other site 272620009407 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 272620009408 FAD binding pocket [chemical binding]; other site 272620009409 FAD binding motif [chemical binding]; other site 272620009410 phosphate binding motif [ion binding]; other site 272620009411 beta-alpha-beta structure motif; other site 272620009412 NAD binding pocket [chemical binding]; other site 272620009413 Heme binding pocket [chemical binding]; other site 272620009414 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 272620009415 Nitrogen regulatory protein P-II; Region: P-II; smart00938 272620009416 response regulator GlrR; Provisional; Region: PRK15115 272620009417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620009418 active site 272620009419 phosphorylation site [posttranslational modification] 272620009420 intermolecular recognition site; other site 272620009421 dimerization interface [polypeptide binding]; other site 272620009422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620009423 Walker A motif; other site 272620009424 ATP binding site [chemical binding]; other site 272620009425 Walker B motif; other site 272620009426 arginine finger; other site 272620009427 hypothetical protein; Provisional; Region: PRK10722 272620009428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272620009429 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620009430 dimer interface [polypeptide binding]; other site 272620009431 phosphorylation site [posttranslational modification] 272620009432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620009433 ATP binding site [chemical binding]; other site 272620009434 Mg2+ binding site [ion binding]; other site 272620009435 G-X-G motif; other site 272620009436 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 272620009437 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 272620009438 dimerization interface [polypeptide binding]; other site 272620009439 ATP binding site [chemical binding]; other site 272620009440 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 272620009441 dimerization interface [polypeptide binding]; other site 272620009442 ATP binding site [chemical binding]; other site 272620009443 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 272620009444 putative active site [active] 272620009445 catalytic triad [active] 272620009446 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 272620009447 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620009448 substrate binding pocket [chemical binding]; other site 272620009449 membrane-bound complex binding site; other site 272620009450 hinge residues; other site 272620009451 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620009452 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620009453 catalytic residue [active] 272620009454 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272620009455 nucleoside/Zn binding site; other site 272620009456 dimer interface [polypeptide binding]; other site 272620009457 catalytic motif [active] 272620009458 hypothetical protein; Provisional; Region: PRK11590 272620009459 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 272620009460 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620009461 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 272620009462 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620009463 putative active site [active] 272620009464 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 272620009465 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 272620009466 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 272620009467 active site 272620009468 hydrophilic channel; other site 272620009469 dimerization interface [polypeptide binding]; other site 272620009470 catalytic residues [active] 272620009471 active site lid [active] 272620009472 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 272620009473 Recombination protein O N terminal; Region: RecO_N; pfam11967 272620009474 Recombination protein O C terminal; Region: RecO_C; pfam02565 272620009475 GTPase Era; Reviewed; Region: era; PRK00089 272620009476 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272620009477 G1 box; other site 272620009478 GTP/Mg2+ binding site [chemical binding]; other site 272620009479 Switch I region; other site 272620009480 G2 box; other site 272620009481 Switch II region; other site 272620009482 G3 box; other site 272620009483 G4 box; other site 272620009484 G5 box; other site 272620009485 KH domain; Region: KH_2; pfam07650 272620009486 ribonuclease III; Reviewed; Region: rnc; PRK00102 272620009487 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272620009488 dimerization interface [polypeptide binding]; other site 272620009489 active site 272620009490 metal binding site [ion binding]; metal-binding site 272620009491 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272620009492 dsRNA binding site [nucleotide binding]; other site 272620009493 signal peptidase I; Provisional; Region: PRK10861 272620009494 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272620009495 Catalytic site [active] 272620009496 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 272620009497 GTP-binding protein LepA; Provisional; Region: PRK05433 272620009498 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272620009499 G1 box; other site 272620009500 putative GEF interaction site [polypeptide binding]; other site 272620009501 GTP/Mg2+ binding site [chemical binding]; other site 272620009502 Switch I region; other site 272620009503 G2 box; other site 272620009504 G3 box; other site 272620009505 Switch II region; other site 272620009506 G4 box; other site 272620009507 G5 box; other site 272620009508 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272620009509 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272620009510 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272620009511 SoxR reducing system protein RseC; Provisional; Region: PRK10862 272620009512 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 272620009513 anti-sigma E factor; Provisional; Region: rseB; PRK09455 272620009514 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 272620009515 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 272620009516 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 272620009517 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 272620009518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272620009519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272620009520 DNA binding residues [nucleotide binding] 272620009521 L-aspartate oxidase; Provisional; Region: PRK09077 272620009522 L-aspartate oxidase; Provisional; Region: PRK06175 272620009523 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272620009524 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272620009525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272620009526 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272620009527 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272620009528 ATP binding site [chemical binding]; other site 272620009529 Mg++ binding site [ion binding]; other site 272620009530 motif III; other site 272620009531 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620009532 nucleotide binding region [chemical binding]; other site 272620009533 ATP-binding site [chemical binding]; other site 272620009534 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 272620009535 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272620009536 ligand binding site [chemical binding]; other site 272620009537 active site 272620009538 UGI interface [polypeptide binding]; other site 272620009539 catalytic site [active] 272620009540 putative methyltransferase; Provisional; Region: PRK10864 272620009541 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272620009542 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272620009543 thioredoxin 2; Provisional; Region: PRK10996 272620009544 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272620009545 catalytic residues [active] 272620009546 Uncharacterized conserved protein [Function unknown]; Region: COG3148 272620009547 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 272620009548 CoA binding domain; Region: CoA_binding_2; pfam13380 272620009549 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 272620009550 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 272620009551 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272620009552 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620009553 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 272620009554 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 272620009555 domain interface [polypeptide binding]; other site 272620009556 putative active site [active] 272620009557 catalytic site [active] 272620009558 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 272620009559 domain interface [polypeptide binding]; other site 272620009560 putative active site [active] 272620009561 catalytic site [active] 272620009562 lipoprotein; Provisional; Region: PRK10759 272620009563 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 272620009564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620009565 putative substrate translocation pore; other site 272620009566 protein disaggregation chaperone; Provisional; Region: PRK10865 272620009567 Clp amino terminal domain; Region: Clp_N; pfam02861 272620009568 Clp amino terminal domain; Region: Clp_N; pfam02861 272620009569 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620009570 Walker A motif; other site 272620009571 ATP binding site [chemical binding]; other site 272620009572 Walker B motif; other site 272620009573 arginine finger; other site 272620009574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620009575 Walker A motif; other site 272620009576 ATP binding site [chemical binding]; other site 272620009577 Walker B motif; other site 272620009578 arginine finger; other site 272620009579 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272620009580 hypothetical protein; Provisional; Region: PRK10723 272620009581 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 272620009582 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 272620009583 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620009584 RNA binding surface [nucleotide binding]; other site 272620009585 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272620009586 active site 272620009587 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 272620009588 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272620009589 30S subunit binding site; other site 272620009590 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 272620009591 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 272620009592 Prephenate dehydratase; Region: PDT; pfam00800 272620009593 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 272620009594 putative L-Phe binding site [chemical binding]; other site 272620009595 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272620009596 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 272620009597 Chorismate mutase type II; Region: CM_2; cl00693 272620009598 prephenate dehydrogenase; Validated; Region: PRK08507 272620009599 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 272620009600 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 272620009601 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 272620009602 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 272620009603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620009604 metal binding site [ion binding]; metal-binding site 272620009605 active site 272620009606 I-site; other site 272620009607 putative outer membrane lipoprotein; Provisional; Region: PRK09967 272620009608 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620009609 ligand binding site [chemical binding]; other site 272620009610 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 272620009611 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 272620009612 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 272620009613 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 272620009614 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272620009615 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272620009616 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 272620009617 RimM N-terminal domain; Region: RimM; pfam01782 272620009618 PRC-barrel domain; Region: PRC; pfam05239 272620009619 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272620009620 signal recognition particle protein; Provisional; Region: PRK10867 272620009621 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272620009622 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272620009623 P loop; other site 272620009624 GTP binding site [chemical binding]; other site 272620009625 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272620009626 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 272620009627 hypothetical protein; Provisional; Region: PRK11573 272620009628 Domain of unknown function DUF21; Region: DUF21; pfam01595 272620009629 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272620009630 Transporter associated domain; Region: CorC_HlyC; smart01091 272620009631 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 272620009632 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272620009633 dimer interface [polypeptide binding]; other site 272620009634 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272620009635 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 272620009636 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 272620009637 recombination and repair protein; Provisional; Region: PRK10869 272620009638 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272620009639 Walker A/P-loop; other site 272620009640 ATP binding site [chemical binding]; other site 272620009641 Q-loop/lid; other site 272620009642 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 272620009643 ABC transporter signature motif; other site 272620009644 Walker B; other site 272620009645 D-loop; other site 272620009646 H-loop/switch region; other site 272620009647 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 272620009648 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 272620009649 hypothetical protein; Validated; Region: PRK01777 272620009650 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 272620009651 putative coenzyme Q binding site [chemical binding]; other site 272620009652 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272620009653 SmpB-tmRNA interface; other site 272620009654 integrase; Provisional; Region: PRK09692 272620009655 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272620009656 active site 272620009657 Int/Topo IB signature motif; other site 272620009658 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 272620009659 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 272620009660 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620009661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620009662 non-specific DNA binding site [nucleotide binding]; other site 272620009663 salt bridge; other site 272620009664 sequence-specific DNA binding site [nucleotide binding]; other site 272620009665 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 272620009666 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 272620009667 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 272620009668 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 272620009669 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 272620009670 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 272620009671 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620009672 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620009673 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620009674 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620009675 HipA-like N-terminal domain; Region: HipA_N; pfam07805 272620009676 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 272620009677 active site 272620009678 dimer interface [polypeptide binding]; other site 272620009679 magnesium binding site [ion binding]; other site 272620009680 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 272620009681 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620009682 tetramer interface [polypeptide binding]; other site 272620009683 active site 272620009684 Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140 272620009685 Glucose-6-phosphate isomerase (GPI); Region: GPI; pfam06560 272620009686 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272620009687 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620009688 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620009689 active site turn [active] 272620009690 phosphorylation site [posttranslational modification] 272620009691 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 272620009692 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 272620009693 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272620009694 RibD C-terminal domain; Region: RibD_C; cl17279 272620009695 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272620009696 Uncharacterized conserved protein [Function unknown]; Region: COG1479 272620009697 Protein of unknown function DUF262; Region: DUF262; pfam03235 272620009698 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 272620009699 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620009700 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620009701 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620009702 putative effector binding pocket; other site 272620009703 putative dimerization interface [polypeptide binding]; other site 272620009704 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 272620009705 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 272620009706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620009707 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272620009708 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620009709 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620009710 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 272620009711 Predicted transcriptional regulator [Transcription]; Region: COG1959 272620009712 Transcriptional regulator; Region: Rrf2; pfam02082 272620009713 Transcriptional regulator; Region: Rrf2; cl17282 272620009714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620009715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620009716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620009717 dimerization interface [polypeptide binding]; other site 272620009718 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 272620009719 agmatinase; Region: agmatinase; TIGR01230 272620009720 oligomer interface [polypeptide binding]; other site 272620009721 putative active site [active] 272620009722 Mn binding site [ion binding]; other site 272620009723 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272620009724 oxidase reductase; Provisional; Region: PTZ00273 272620009725 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 272620009726 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 272620009727 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620009728 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620009729 substrate binding pocket [chemical binding]; other site 272620009730 membrane-bound complex binding site; other site 272620009731 hinge residues; other site 272620009732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620009733 dimer interface [polypeptide binding]; other site 272620009734 conserved gate region; other site 272620009735 ABC-ATPase subunit interface; other site 272620009736 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 272620009737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 272620009738 Walker A/P-loop; other site 272620009739 ATP binding site [chemical binding]; other site 272620009740 Q-loop/lid; other site 272620009741 ABC transporter signature motif; other site 272620009742 Walker B; other site 272620009743 D-loop; other site 272620009744 H-loop/switch region; other site 272620009745 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272620009746 intersubunit interface [polypeptide binding]; other site 272620009747 active site 272620009748 Zn2+ binding site [ion binding]; other site 272620009749 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 272620009750 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 272620009751 putative ligand binding site [chemical binding]; other site 272620009752 NAD binding site [chemical binding]; other site 272620009753 dimerization interface [polypeptide binding]; other site 272620009754 catalytic site [active] 272620009755 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 272620009756 classical (c) SDRs; Region: SDR_c; cd05233 272620009757 NAD(P) binding site [chemical binding]; other site 272620009758 active site 272620009759 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620009760 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620009761 substrate binding pocket [chemical binding]; other site 272620009762 membrane-bound complex binding site; other site 272620009763 hinge residues; other site 272620009764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620009765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620009766 DNA binding residues [nucleotide binding] 272620009767 dimerization interface [polypeptide binding]; other site 272620009768 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620009769 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620009770 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620009771 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620009772 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620009773 PapC N-terminal domain; Region: PapC_N; pfam13954 272620009774 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620009775 PapC C-terminal domain; Region: PapC_C; pfam13953 272620009776 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620009777 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620009778 PapC N-terminal domain; Region: PapC_N; pfam13954 272620009779 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620009780 PapC C-terminal domain; Region: PapC_C; pfam13953 272620009781 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620009782 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620009783 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620009784 Fimbrial protein; Region: Fimbrial; cl01416 272620009785 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272620009786 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272620009787 NAD(P) binding site [chemical binding]; other site 272620009788 catalytic residues [active] 272620009789 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 272620009790 GAF domain; Region: GAF; pfam01590 272620009791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620009792 Walker A motif; other site 272620009793 ATP binding site [chemical binding]; other site 272620009794 Walker B motif; other site 272620009795 arginine finger; other site 272620009796 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620009797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620009798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620009799 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 272620009800 putative effector binding pocket; other site 272620009801 putative dimerization interface [polypeptide binding]; other site 272620009802 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272620009803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620009804 dimerization interface [polypeptide binding]; other site 272620009805 putative DNA binding site [nucleotide binding]; other site 272620009806 putative Zn2+ binding site [ion binding]; other site 272620009807 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 272620009808 active site residue [active] 272620009809 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 272620009810 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 272620009811 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 272620009812 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 272620009813 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 272620009814 hypothetical protein; Provisional; Region: PRK10556 272620009815 hypothetical protein; Provisional; Region: PRK10132 272620009816 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620009817 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620009818 DNA-binding site [nucleotide binding]; DNA binding site 272620009819 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620009820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620009821 homodimer interface [polypeptide binding]; other site 272620009822 catalytic residue [active] 272620009823 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272620009824 Uncharacterized conserved protein [Function unknown]; Region: COG2128 272620009825 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 272620009826 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 272620009827 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 272620009828 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272620009829 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272620009830 active site 272620009831 dimer interface [polypeptide binding]; other site 272620009832 catalytic residues [active] 272620009833 effector binding site; other site 272620009834 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 272620009835 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 272620009836 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272620009837 dimer interface [polypeptide binding]; other site 272620009838 putative radical transfer pathway; other site 272620009839 diiron center [ion binding]; other site 272620009840 tyrosyl radical; other site 272620009841 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 272620009842 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 272620009843 Walker A/P-loop; other site 272620009844 ATP binding site [chemical binding]; other site 272620009845 Q-loop/lid; other site 272620009846 ABC transporter signature motif; other site 272620009847 Walker B; other site 272620009848 D-loop; other site 272620009849 H-loop/switch region; other site 272620009850 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 272620009851 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 272620009852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620009853 dimer interface [polypeptide binding]; other site 272620009854 conserved gate region; other site 272620009855 putative PBP binding loops; other site 272620009856 ABC-ATPase subunit interface; other site 272620009857 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 272620009858 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 272620009859 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 272620009860 putative L-valine exporter; Provisional; Region: PRK10408 272620009861 transcriptional repressor MprA; Provisional; Region: PRK10870 272620009862 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620009863 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 272620009864 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620009865 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620009866 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272620009867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620009868 putative substrate translocation pore; other site 272620009869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620009870 2-isopropylmalate synthase; Validated; Region: PRK03739 272620009871 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 272620009872 active site 272620009873 catalytic residues [active] 272620009874 metal binding site [ion binding]; metal-binding site 272620009875 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 272620009876 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620009877 Helix-turn-helix domain; Region: HTH_18; pfam12833 272620009878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620009879 S-ribosylhomocysteinase; Provisional; Region: PRK02260 272620009880 glutamate--cysteine ligase; Provisional; Region: PRK02107 272620009881 Predicted membrane protein [Function unknown]; Region: COG1238 272620009882 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 272620009883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620009884 motif II; other site 272620009885 BON domain; Region: BON; pfam04972 272620009886 carbon storage regulator; Provisional; Region: PRK01712 272620009887 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272620009888 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272620009889 motif 1; other site 272620009890 active site 272620009891 motif 2; other site 272620009892 motif 3; other site 272620009893 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272620009894 DHHA1 domain; Region: DHHA1; pfam02272 272620009895 recombination regulator RecX; Reviewed; Region: recX; PRK00117 272620009896 recombinase A; Provisional; Region: recA; PRK09354 272620009897 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272620009898 hexamer interface [polypeptide binding]; other site 272620009899 Walker A motif; other site 272620009900 ATP binding site [chemical binding]; other site 272620009901 Walker B motif; other site 272620009902 hypothetical protein; Validated; Region: PRK03661 272620009903 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272620009904 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272620009905 metal binding site [ion binding]; metal-binding site 272620009906 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272620009907 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620009908 ABC-ATPase subunit interface; other site 272620009909 dimer interface [polypeptide binding]; other site 272620009910 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272620009911 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272620009912 Transglycosylase SLT domain; Region: SLT_2; pfam13406 272620009913 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620009914 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620009915 catalytic residue [active] 272620009916 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 272620009917 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 272620009918 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 272620009919 Nucleoside recognition; Region: Gate; pfam07670 272620009920 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 272620009921 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 272620009922 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 272620009923 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 272620009924 putative NAD(P) binding site [chemical binding]; other site 272620009925 active site 272620009926 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 272620009927 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272620009928 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620009929 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 272620009930 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272620009931 putative active site [active] 272620009932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272620009933 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 272620009934 GAF domain; Region: GAF; pfam01590 272620009935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620009936 Walker A motif; other site 272620009937 ATP binding site [chemical binding]; other site 272620009938 Walker B motif; other site 272620009939 arginine finger; other site 272620009940 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 272620009941 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272620009942 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272620009943 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 272620009944 iron binding site [ion binding]; other site 272620009945 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 272620009946 UAF complex subunit Rrn10; Region: UAF_Rrn10; pfam05234 272620009947 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620009948 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620009949 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 272620009950 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 272620009951 Acylphosphatase; Region: Acylphosphatase; pfam00708 272620009952 HypF finger; Region: zf-HYPF; pfam07503 272620009953 HypF finger; Region: zf-HYPF; pfam07503 272620009954 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 272620009955 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 272620009956 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 272620009957 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620009958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620009959 DNA binding site [nucleotide binding] 272620009960 domain linker motif; other site 272620009961 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 272620009962 dimerization interface (closed form) [polypeptide binding]; other site 272620009963 ligand binding site [chemical binding]; other site 272620009964 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 272620009965 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620009966 active site turn [active] 272620009967 phosphorylation site [posttranslational modification] 272620009968 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 272620009969 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 272620009970 beta-galactosidase; Region: BGL; TIGR03356 272620009971 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 272620009972 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 272620009973 nickel binding site [ion binding]; other site 272620009974 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 272620009975 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 272620009976 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 272620009977 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 272620009978 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 272620009979 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 272620009980 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 272620009981 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 272620009982 NADH dehydrogenase; Region: NADHdh; cl00469 272620009983 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 272620009984 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 272620009985 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 272620009986 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 272620009987 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 272620009988 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 272620009989 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 272620009990 hydrogenase assembly chaperone; Provisional; Region: PRK10409 272620009991 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 272620009992 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 272620009993 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 272620009994 dimerization interface [polypeptide binding]; other site 272620009995 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 272620009996 ATP binding site [chemical binding]; other site 272620009997 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 272620009998 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272620009999 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272620010000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620010001 Walker A motif; other site 272620010002 ATP binding site [chemical binding]; other site 272620010003 Walker B motif; other site 272620010004 arginine finger; other site 272620010005 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 272620010006 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272620010007 beta-galactosidase; Region: BGL; TIGR03356 272620010008 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 272620010009 Interdomain contacts; other site 272620010010 Cytokine receptor motif; other site 272620010011 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 272620010012 putative metal binding site [ion binding]; other site 272620010013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272620010014 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272620010015 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272620010016 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272620010017 active site 272620010018 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272620010019 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 272620010020 methionine cluster; other site 272620010021 active site 272620010022 phosphorylation site [posttranslational modification] 272620010023 metal binding site [ion binding]; metal-binding site 272620010024 fructokinase; Reviewed; Region: PRK09557 272620010025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272620010026 nucleotide binding site [chemical binding]; other site 272620010027 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620010028 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620010029 DNA binding site [nucleotide binding] 272620010030 domain linker motif; other site 272620010031 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272620010032 ligand binding site [chemical binding]; other site 272620010033 dimerization interface [polypeptide binding]; other site 272620010034 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 272620010035 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 272620010036 metal binding site [ion binding]; metal-binding site 272620010037 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 272620010038 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 272620010039 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272620010040 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620010041 ABC-ATPase subunit interface; other site 272620010042 dimer interface [polypeptide binding]; other site 272620010043 putative PBP binding regions; other site 272620010044 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 272620010045 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620010046 ABC-ATPase subunit interface; other site 272620010047 dimer interface [polypeptide binding]; other site 272620010048 putative PBP binding regions; other site 272620010049 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 272620010050 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620010051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620010053 dimerization interface [polypeptide binding]; other site 272620010054 Membrane transport protein; Region: Mem_trans; cl09117 272620010055 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 272620010056 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620010057 PYR/PP interface [polypeptide binding]; other site 272620010058 dimer interface [polypeptide binding]; other site 272620010059 TPP binding site [chemical binding]; other site 272620010060 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 272620010061 TPP-binding site [chemical binding]; other site 272620010062 Rdx family; Region: Rdx; cl01407 272620010063 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 272620010064 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620010065 N-terminal plug; other site 272620010066 ligand-binding site [chemical binding]; other site 272620010067 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 272620010068 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 272620010069 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 272620010070 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 272620010071 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 272620010072 putative hemin binding site; other site 272620010073 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 272620010074 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 272620010075 ABC-ATPase subunit interface; other site 272620010076 dimer interface [polypeptide binding]; other site 272620010077 putative PBP binding regions; other site 272620010078 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 272620010079 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 272620010080 Walker A/P-loop; other site 272620010081 ATP binding site [chemical binding]; other site 272620010082 Q-loop/lid; other site 272620010083 ABC transporter signature motif; other site 272620010084 Walker B; other site 272620010085 D-loop; other site 272620010086 H-loop/switch region; other site 272620010087 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 272620010088 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 272620010089 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 272620010090 MutS domain I; Region: MutS_I; pfam01624 272620010091 MutS domain II; Region: MutS_II; pfam05188 272620010092 MutS domain III; Region: MutS_III; pfam05192 272620010093 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 272620010094 Walker A/P-loop; other site 272620010095 ATP binding site [chemical binding]; other site 272620010096 Q-loop/lid; other site 272620010097 ABC transporter signature motif; other site 272620010098 Walker B; other site 272620010099 D-loop; other site 272620010100 H-loop/switch region; other site 272620010101 Hok/gef family; Region: HOK_GEF; pfam01848 272620010102 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 272620010103 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 272620010104 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 272620010105 Flavoprotein; Region: Flavoprotein; pfam02441 272620010106 MarR family; Region: MarR_2; cl17246 272620010107 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620010108 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620010109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010110 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620010111 putative effector binding pocket; other site 272620010112 dimerization interface [polypeptide binding]; other site 272620010113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620010114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010115 putative substrate translocation pore; other site 272620010116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 272620010117 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 272620010118 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272620010119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272620010120 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272620010121 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272620010122 DNA binding residues [nucleotide binding] 272620010123 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 272620010124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620010125 Peptidase family M23; Region: Peptidase_M23; pfam01551 272620010126 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 272620010127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620010128 S-adenosylmethionine binding site [chemical binding]; other site 272620010129 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 272620010130 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 272620010131 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 272620010132 Permutation of conserved domain; other site 272620010133 active site 272620010134 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272620010135 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272620010136 homotrimer interaction site [polypeptide binding]; other site 272620010137 zinc binding site [ion binding]; other site 272620010138 CDP-binding sites; other site 272620010139 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272620010140 substrate binding site; other site 272620010141 dimer interface; other site 272620010142 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 272620010143 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 272620010144 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 272620010145 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 272620010146 ligand-binding site [chemical binding]; other site 272620010147 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 272620010148 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 272620010149 CysD dimerization site [polypeptide binding]; other site 272620010150 G1 box; other site 272620010151 putative GEF interaction site [polypeptide binding]; other site 272620010152 GTP/Mg2+ binding site [chemical binding]; other site 272620010153 Switch I region; other site 272620010154 G2 box; other site 272620010155 G3 box; other site 272620010156 Switch II region; other site 272620010157 G4 box; other site 272620010158 G5 box; other site 272620010159 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 272620010160 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 272620010161 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 272620010162 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272620010163 Active Sites [active] 272620010164 siroheme synthase; Provisional; Region: cysG; PRK10637 272620010165 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272620010166 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 272620010167 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272620010168 active site 272620010169 SAM binding site [chemical binding]; other site 272620010170 homodimer interface [polypeptide binding]; other site 272620010171 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 272620010172 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 272620010173 metal binding site [ion binding]; metal-binding site 272620010174 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 272620010175 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 272620010176 Active Sites [active] 272620010177 sulfite reductase subunit beta; Provisional; Region: PRK13504 272620010178 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272620010179 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272620010180 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 272620010181 Flavodoxin; Region: Flavodoxin_1; pfam00258 272620010182 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 272620010183 FAD binding pocket [chemical binding]; other site 272620010184 FAD binding motif [chemical binding]; other site 272620010185 catalytic residues [active] 272620010186 NAD binding pocket [chemical binding]; other site 272620010187 phosphate binding motif [ion binding]; other site 272620010188 beta-alpha-beta structure motif; other site 272620010189 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 272620010190 active site 272620010191 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 272620010192 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 272620010193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620010194 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 272620010195 NAD(P) binding site [chemical binding]; other site 272620010196 active site 272620010197 enolase; Provisional; Region: eno; PRK00077 272620010198 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272620010199 dimer interface [polypeptide binding]; other site 272620010200 metal binding site [ion binding]; metal-binding site 272620010201 substrate binding pocket [chemical binding]; other site 272620010202 CTP synthetase; Validated; Region: pyrG; PRK05380 272620010203 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272620010204 Catalytic site [active] 272620010205 active site 272620010206 UTP binding site [chemical binding]; other site 272620010207 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272620010208 active site 272620010209 putative oxyanion hole; other site 272620010210 catalytic triad [active] 272620010211 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 272620010212 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 272620010213 homodimer interface [polypeptide binding]; other site 272620010214 metal binding site [ion binding]; metal-binding site 272620010215 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 272620010216 homodimer interface [polypeptide binding]; other site 272620010217 active site 272620010218 putative chemical substrate binding site [chemical binding]; other site 272620010219 metal binding site [ion binding]; metal-binding site 272620010220 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 272620010221 HD domain; Region: HD_4; pfam13328 272620010222 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272620010223 synthetase active site [active] 272620010224 NTP binding site [chemical binding]; other site 272620010225 metal binding site [ion binding]; metal-binding site 272620010226 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272620010227 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272620010228 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 272620010229 TRAM domain; Region: TRAM; pfam01938 272620010230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620010231 S-adenosylmethionine binding site [chemical binding]; other site 272620010232 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 272620010233 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 272620010234 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620010235 dimerization interface [polypeptide binding]; other site 272620010236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620010237 dimer interface [polypeptide binding]; other site 272620010238 phosphorylation site [posttranslational modification] 272620010239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620010240 ATP binding site [chemical binding]; other site 272620010241 Mg2+ binding site [ion binding]; other site 272620010242 G-X-G motif; other site 272620010243 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 272620010244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620010245 active site 272620010246 phosphorylation site [posttranslational modification] 272620010247 intermolecular recognition site; other site 272620010248 dimerization interface [polypeptide binding]; other site 272620010249 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272620010250 putative binding surface; other site 272620010251 active site 272620010252 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 272620010253 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 272620010254 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 272620010255 active site 272620010256 tetramer interface [polypeptide binding]; other site 272620010257 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 272620010258 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 272620010259 active site 272620010260 tetramer interface [polypeptide binding]; other site 272620010261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010262 D-galactonate transporter; Region: 2A0114; TIGR00893 272620010263 putative substrate translocation pore; other site 272620010264 flavodoxin; Provisional; Region: PRK08105 272620010265 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272620010266 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 272620010267 probable active site [active] 272620010268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 272620010269 SecY interacting protein Syd; Provisional; Region: PRK04968 272620010270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 272620010271 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 272620010272 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 272620010273 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 272620010274 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 272620010275 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272620010276 serine transporter; Region: stp; TIGR00814 272620010277 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 272620010278 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 272620010279 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 272620010280 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272620010281 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620010282 substrate binding pocket [chemical binding]; other site 272620010283 membrane-bound complex binding site; other site 272620010284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010285 putative substrate translocation pore; other site 272620010286 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 272620010287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010288 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 272620010289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620010290 dimer interface [polypeptide binding]; other site 272620010291 conserved gate region; other site 272620010292 ABC-ATPase subunit interface; other site 272620010293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620010294 Walker A/P-loop; other site 272620010295 ATP binding site [chemical binding]; other site 272620010296 ABC transporter; Region: ABC_tran; pfam00005 272620010297 Q-loop/lid; other site 272620010298 ABC transporter signature motif; other site 272620010299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 272620010300 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 272620010301 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 272620010302 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 272620010303 active site 272620010304 dimer interface [polypeptide binding]; other site 272620010305 non-prolyl cis peptide bond; other site 272620010306 insertion regions; other site 272620010307 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 272620010308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620010309 Walker A motif; other site 272620010310 ATP binding site [chemical binding]; other site 272620010311 Walker B motif; other site 272620010312 arginine finger; other site 272620010313 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620010314 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 272620010315 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620010316 substrate binding pocket [chemical binding]; other site 272620010317 membrane-bound complex binding site; other site 272620010318 hinge residues; other site 272620010319 flap endonuclease-like protein; Provisional; Region: PRK09482 272620010320 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272620010321 active site 272620010322 metal binding site 1 [ion binding]; metal-binding site 272620010323 putative 5' ssDNA interaction site; other site 272620010324 metal binding site 3; metal-binding site 272620010325 metal binding site 2 [ion binding]; metal-binding site 272620010326 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272620010327 putative DNA binding site [nucleotide binding]; other site 272620010328 putative metal binding site [ion binding]; other site 272620010329 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 272620010330 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 272620010331 dimer interface [polypeptide binding]; other site 272620010332 active site 272620010333 metal binding site [ion binding]; metal-binding site 272620010334 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 272620010335 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 272620010336 intersubunit interface [polypeptide binding]; other site 272620010337 active site 272620010338 Zn2+ binding site [ion binding]; other site 272620010339 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 272620010340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010341 putative substrate translocation pore; other site 272620010342 L-fucose isomerase; Provisional; Region: fucI; PRK10991 272620010343 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 272620010344 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272620010345 trimer interface [polypeptide binding]; other site 272620010346 substrate binding site [chemical binding]; other site 272620010347 Mn binding site [ion binding]; other site 272620010348 L-fuculokinase; Provisional; Region: PRK10331 272620010349 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272620010350 nucleotide binding site [chemical binding]; other site 272620010351 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 272620010352 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 272620010353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620010354 DNA-binding site [nucleotide binding]; DNA binding site 272620010355 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620010356 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 272620010357 FtsJ-like methyltransferase; Region: FtsJ; cl17430 272620010358 hypothetical protein; Provisional; Region: PRK10873 272620010359 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 272620010360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010361 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620010362 dimerization interface [polypeptide binding]; other site 272620010363 substrate binding pocket [chemical binding]; other site 272620010364 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 272620010365 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272620010366 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 272620010367 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620010368 catalytic residue [active] 272620010369 Fe-S metabolism associated domain; Region: SufE; cl00951 272620010370 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 272620010371 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 272620010372 putative ATP binding site [chemical binding]; other site 272620010373 putative substrate interface [chemical binding]; other site 272620010374 murein transglycosylase A; Provisional; Region: mltA; PRK11162 272620010375 MltA specific insert domain; Region: MltA; pfam03562 272620010376 3D domain; Region: 3D; pfam06725 272620010377 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 272620010378 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 272620010379 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 272620010380 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620010381 ligand binding site [chemical binding]; other site 272620010382 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 272620010383 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 272620010384 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 272620010385 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 272620010386 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 272620010387 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 272620010388 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 272620010389 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 272620010390 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 272620010391 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 272620010392 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 272620010393 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 272620010394 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 272620010395 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 272620010396 putative dimer interface [polypeptide binding]; other site 272620010397 active site pocket [active] 272620010398 putative cataytic base [active] 272620010399 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 272620010400 homotrimer interface [polypeptide binding]; other site 272620010401 Walker A motif; other site 272620010402 GTP binding site [chemical binding]; other site 272620010403 Walker B motif; other site 272620010404 cobyric acid synthase; Provisional; Region: PRK00784 272620010405 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272620010406 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272620010407 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 272620010408 catalytic triad [active] 272620010409 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 272620010410 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272620010411 Walker A/P-loop; other site 272620010412 ATP binding site [chemical binding]; other site 272620010413 Q-loop/lid; other site 272620010414 ABC transporter signature motif; other site 272620010415 Walker B; other site 272620010416 D-loop; other site 272620010417 H-loop/switch region; other site 272620010418 cobalt transport protein CbiQ; Provisional; Region: PRK15485 272620010419 cobalt transport protein CbiN; Provisional; Region: PRK02898 272620010420 cobalt transport protein CbiM; Validated; Region: PRK08319 272620010421 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 272620010422 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 272620010423 active site 272620010424 SAM binding site [chemical binding]; other site 272620010425 homodimer interface [polypeptide binding]; other site 272620010426 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 272620010427 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 272620010428 active site 272620010429 C-terminal domain interface [polypeptide binding]; other site 272620010430 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 272620010431 active site 272620010432 N-terminal domain interface [polypeptide binding]; other site 272620010433 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 272620010434 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 272620010435 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 272620010436 active site 272620010437 SAM binding site [chemical binding]; other site 272620010438 homodimer interface [polypeptide binding]; other site 272620010439 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 272620010440 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 272620010441 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 272620010442 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 272620010443 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 272620010444 active site 272620010445 SAM binding site [chemical binding]; other site 272620010446 homodimer interface [polypeptide binding]; other site 272620010447 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 272620010448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620010449 S-adenosylmethionine binding site [chemical binding]; other site 272620010450 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 272620010451 active site 272620010452 putative homodimer interface [polypeptide binding]; other site 272620010453 SAM binding site [chemical binding]; other site 272620010454 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 272620010455 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 272620010456 Precorrin-8X methylmutase; Region: CbiC; pfam02570 272620010457 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 272620010458 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 272620010459 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 272620010460 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 272620010461 catalytic triad [active] 272620010462 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 272620010463 Sensory domain found in PocR; Region: PocR; pfam10114 272620010464 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620010465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620010466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620010467 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272620010468 amphipathic channel; other site 272620010469 Asn-Pro-Ala signature motifs; other site 272620010470 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272620010471 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 272620010472 Hexamer interface [polypeptide binding]; other site 272620010473 Putative hexagonal pore residue; other site 272620010474 propanediol utilization protein PduB; Provisional; Region: PRK15415 272620010475 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 272620010476 putative hexamer interface [polypeptide binding]; other site 272620010477 putative hexagonal pore; other site 272620010478 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 272620010479 putative hexamer interface [polypeptide binding]; other site 272620010480 putative hexagonal pore; other site 272620010481 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 272620010482 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 272620010483 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 272620010484 alpha-beta subunit interface [polypeptide binding]; other site 272620010485 alpha-gamma subunit interface [polypeptide binding]; other site 272620010486 active site 272620010487 substrate and K+ binding site; other site 272620010488 K+ binding site [ion binding]; other site 272620010489 cobalamin binding site [chemical binding]; other site 272620010490 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 272620010491 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 272620010492 Cell division protein FtsA; Region: FtsA; cl17206 272620010493 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 272620010494 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 272620010495 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272620010496 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 272620010497 Hexamer interface [polypeptide binding]; other site 272620010498 Putative hexagonal pore residue; other site 272620010499 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 272620010500 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 272620010501 Hexamer interface [polypeptide binding]; other site 272620010502 Hexagonal pore residue; other site 272620010503 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 272620010504 Propanediol utilisation protein PduL; Region: PduL; pfam06130 272620010505 Propanediol utilisation protein PduL; Region: PduL; pfam06130 272620010506 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 272620010507 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 272620010508 Hexamer/Pentamer interface [polypeptide binding]; other site 272620010509 central pore; other site 272620010510 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 272620010511 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 272620010512 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 272620010513 putative catalytic cysteine [active] 272620010514 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272620010515 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 272620010516 active site 272620010517 NAD binding site [chemical binding]; other site 272620010518 metal binding site [ion binding]; metal-binding site 272620010519 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 272620010520 SLBB domain; Region: SLBB; pfam10531 272620010521 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 272620010522 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 272620010523 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 272620010524 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 272620010525 putative hexamer interface [polypeptide binding]; other site 272620010526 putative hexagonal pore; other site 272620010527 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 272620010528 putative hexamer interface [polypeptide binding]; other site 272620010529 putative hexagonal pore; other site 272620010530 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 272620010531 putative hexamer interface [polypeptide binding]; other site 272620010532 putative hexagonal pore; other site 272620010533 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 272620010534 G3 box; other site 272620010535 Switch II region; other site 272620010536 GTP/Mg2+ binding site [chemical binding]; other site 272620010537 G4 box; other site 272620010538 G5 box; other site 272620010539 propionate kinase; Reviewed; Region: PRK12397 272620010540 propionate/acetate kinase; Provisional; Region: PRK12379 272620010541 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 272620010542 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 272620010543 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620010544 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620010545 homodimer interface [polypeptide binding]; other site 272620010546 catalytic residue [active] 272620010547 AMIN domain; Region: AMIN; pfam11741 272620010548 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272620010549 active site 272620010550 metal binding site [ion binding]; metal-binding site 272620010551 N-acetylglutamate synthase; Validated; Region: PRK05279 272620010552 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 272620010553 putative feedback inhibition sensing region; other site 272620010554 putative nucleotide binding site [chemical binding]; other site 272620010555 putative substrate binding site [chemical binding]; other site 272620010556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620010557 Coenzyme A binding pocket [chemical binding]; other site 272620010558 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 272620010559 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 272620010560 Family description; Region: UvrD_C_2; pfam13538 272620010561 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 272620010562 protease3; Provisional; Region: PRK15101 272620010563 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 272620010564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272620010565 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272620010566 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 272620010567 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 272620010568 hypothetical protein; Provisional; Region: PRK10332 272620010569 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 272620010570 hypothetical protein; Provisional; Region: PRK11521 272620010571 hypothetical protein; Provisional; Region: PRK10557 272620010572 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 272620010573 hypothetical protein; Provisional; Region: PRK10506 272620010574 thymidylate synthase; Reviewed; Region: thyA; PRK01827 272620010575 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272620010576 dimerization interface [polypeptide binding]; other site 272620010577 active site 272620010578 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 272620010579 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 272620010580 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 272620010581 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272620010582 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272620010583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272620010584 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 272620010585 putative active site [active] 272620010586 Ap4A binding site [chemical binding]; other site 272620010587 nudix motif; other site 272620010588 putative metal binding site [ion binding]; other site 272620010589 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 272620010590 putative DNA-binding cleft [nucleotide binding]; other site 272620010591 putative DNA clevage site; other site 272620010592 molecular lever; other site 272620010593 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 272620010594 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 272620010595 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620010596 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620010597 active site 272620010598 catalytic tetrad [active] 272620010599 lysophospholipid transporter LplT; Provisional; Region: PRK11195 272620010600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010601 putative substrate translocation pore; other site 272620010602 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 272620010603 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272620010604 putative acyl-acceptor binding pocket; other site 272620010605 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 272620010606 acyl-activating enzyme (AAE) consensus motif; other site 272620010607 putative AMP binding site [chemical binding]; other site 272620010608 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 272620010609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620010610 DNA binding site [nucleotide binding] 272620010611 domain linker motif; other site 272620010612 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 272620010613 dimerization interface (closed form) [polypeptide binding]; other site 272620010614 ligand binding site [chemical binding]; other site 272620010615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620010616 Coenzyme A binding pocket [chemical binding]; other site 272620010617 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 272620010618 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620010619 DNA-binding site [nucleotide binding]; DNA binding site 272620010620 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272620010621 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272620010622 beta-galactosidase; Region: BGL; TIGR03356 272620010623 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272620010624 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272620010625 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620010626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620010627 DNA binding site [nucleotide binding] 272620010628 domain linker motif; other site 272620010629 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 272620010630 dimerization interface (closed form) [polypeptide binding]; other site 272620010631 ligand binding site [chemical binding]; other site 272620010632 diaminopimelate decarboxylase; Provisional; Region: PRK11165 272620010633 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 272620010634 active site 272620010635 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272620010636 substrate binding site [chemical binding]; other site 272620010637 catalytic residues [active] 272620010638 dimer interface [polypeptide binding]; other site 272620010639 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 272620010640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010641 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620010642 dimerization interface [polypeptide binding]; other site 272620010643 putative racemase; Provisional; Region: PRK10200 272620010644 aspartate racemase; Region: asp_race; TIGR00035 272620010645 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272620010646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620010647 dimer interface [polypeptide binding]; other site 272620010648 conserved gate region; other site 272620010649 putative PBP binding loops; other site 272620010650 ABC-ATPase subunit interface; other site 272620010651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272620010652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620010653 dimer interface [polypeptide binding]; other site 272620010654 conserved gate region; other site 272620010655 putative PBP binding loops; other site 272620010656 ABC-ATPase subunit interface; other site 272620010657 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272620010658 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272620010659 Walker A/P-loop; other site 272620010660 ATP binding site [chemical binding]; other site 272620010661 Q-loop/lid; other site 272620010662 ABC transporter signature motif; other site 272620010663 Walker B; other site 272620010664 D-loop; other site 272620010665 H-loop/switch region; other site 272620010666 TOBE domain; Region: TOBE; pfam03459 272620010667 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272620010668 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272620010669 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 272620010670 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272620010671 substrate binding [chemical binding]; other site 272620010672 active site 272620010673 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 272620010674 galactoside permease; Reviewed; Region: lacY; PRK09528 272620010675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010676 putative substrate translocation pore; other site 272620010677 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620010678 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620010679 DNA binding site [nucleotide binding] 272620010680 domain linker motif; other site 272620010681 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 272620010682 putative dimerization interface [polypeptide binding]; other site 272620010683 putative ligand binding site [chemical binding]; other site 272620010684 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272620010685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010686 putative substrate translocation pore; other site 272620010687 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010688 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 272620010689 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 272620010690 NADP binding site [chemical binding]; other site 272620010691 homodimer interface [polypeptide binding]; other site 272620010692 active site 272620010693 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 272620010694 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 272620010695 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 272620010696 putative acyltransferase; Provisional; Region: PRK05790 272620010697 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620010698 dimer interface [polypeptide binding]; other site 272620010699 active site 272620010700 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620010701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 272620010703 dimerization interface [polypeptide binding]; other site 272620010704 Predicted membrane protein [Function unknown]; Region: COG4125 272620010705 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272620010706 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 272620010707 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272620010708 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 272620010709 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620010710 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620010711 active site 272620010712 catalytic tetrad [active] 272620010713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620010714 DNA binding residues [nucleotide binding] 272620010715 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620010716 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620010717 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620010718 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620010719 PapC N-terminal domain; Region: PapC_N; pfam13954 272620010720 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620010721 PapC C-terminal domain; Region: PapC_C; pfam13953 272620010722 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620010723 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620010724 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620010725 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620010726 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620010727 EamA-like transporter family; Region: EamA; pfam00892 272620010728 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272620010729 EamA-like transporter family; Region: EamA; pfam00892 272620010730 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620010731 MarR family; Region: MarR; pfam01047 272620010732 MarR family; Region: MarR_2; cl17246 272620010733 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 272620010734 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 272620010735 Int/Topo IB signature motif; other site 272620010736 tyrosine recombinase; Provisional; Region: PRK09871 272620010737 active site 272620010738 DNA binding site [nucleotide binding] 272620010739 Int/Topo IB signature motif; other site 272620010740 Fimbrial protein; Region: Fimbrial; cl01416 272620010741 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620010742 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620010743 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620010744 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620010745 outer membrane usher protein; Provisional; Region: PRK15193 272620010746 PapC N-terminal domain; Region: PapC_N; pfam13954 272620010747 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620010748 PapC C-terminal domain; Region: PapC_C; pfam13953 272620010749 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620010750 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 272620010751 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 272620010752 mannosyl binding site [chemical binding]; other site 272620010753 Fimbrial protein; Region: Fimbrial; cl01416 272620010754 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272620010755 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620010756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620010757 Coenzyme A binding pocket [chemical binding]; other site 272620010758 Uncharacterized conserved protein [Function unknown]; Region: COG3592 272620010759 multidrug resistance protein MdtN; Provisional; Region: PRK10476 272620010760 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620010761 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620010762 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 272620010763 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 272620010764 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 272620010765 POT family; Region: PTR2; cl17359 272620010766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010767 putative substrate translocation pore; other site 272620010768 POT family; Region: PTR2; cl17359 272620010769 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272620010770 ArsC family; Region: ArsC; pfam03960 272620010771 catalytic residues [active] 272620010772 arsenical pump membrane protein; Provisional; Region: PRK15445 272620010773 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272620010774 transmembrane helices; other site 272620010775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620010776 dimerization interface [polypeptide binding]; other site 272620010777 putative DNA binding site [nucleotide binding]; other site 272620010778 putative Zn2+ binding site [ion binding]; other site 272620010779 YCII-related domain; Region: YCII; cl00999 272620010780 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 272620010781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620010782 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620010784 dimerization interface [polypeptide binding]; other site 272620010785 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 272620010786 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620010787 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620010788 active site 272620010789 catalytic tetrad [active] 272620010790 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272620010791 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272620010792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620010793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010794 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 272620010795 putative substrate binding pocket [chemical binding]; other site 272620010796 putative dimerization interface [polypeptide binding]; other site 272620010797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010798 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620010799 putative substrate translocation pore; other site 272620010800 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 272620010801 Peptidase family M23; Region: Peptidase_M23; pfam01551 272620010802 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 272620010803 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 272620010804 active site 272620010805 metal binding site [ion binding]; metal-binding site 272620010806 nudix motif; other site 272620010807 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 272620010808 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272620010809 dimer interface [polypeptide binding]; other site 272620010810 putative anticodon binding site; other site 272620010811 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272620010812 motif 1; other site 272620010813 active site 272620010814 motif 2; other site 272620010815 motif 3; other site 272620010816 peptide chain release factor 2; Provisional; Region: PRK08787 272620010817 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272620010818 RF-1 domain; Region: RF-1; pfam00472 272620010819 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 272620010820 DHH family; Region: DHH; pfam01368 272620010821 DHHA1 domain; Region: DHHA1; pfam02272 272620010822 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 272620010823 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 272620010824 dimerization domain [polypeptide binding]; other site 272620010825 dimer interface [polypeptide binding]; other site 272620010826 catalytic residues [active] 272620010827 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 272620010828 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272620010829 active site 272620010830 Int/Topo IB signature motif; other site 272620010831 flavodoxin FldB; Provisional; Region: PRK12359 272620010832 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 272620010833 hypothetical protein; Provisional; Region: PRK10878 272620010834 putative global regulator; Reviewed; Region: PRK09559 272620010835 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 272620010836 hemolysin; Provisional; Region: PRK15087 272620010837 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 272620010838 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 272620010839 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620010840 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620010841 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620010842 putative active site [active] 272620010843 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 272620010844 beta-galactosidase; Region: BGL; TIGR03356 272620010845 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 272620010846 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 272620010847 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 272620010848 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272620010849 DsbD alpha interface [polypeptide binding]; other site 272620010850 catalytic residues [active] 272620010851 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 272620010852 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272620010853 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272620010854 catalytic residues [active] 272620010855 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 272620010856 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272620010857 catalytic residues [active] 272620010858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620010859 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620010860 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620010861 putative transposase OrfB; Reviewed; Region: PHA02517 272620010862 HTH-like domain; Region: HTH_21; pfam13276 272620010863 Integrase core domain; Region: rve; pfam00665 272620010864 Integrase core domain; Region: rve_2; pfam13333 272620010865 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 272620010866 classical (c) SDRs; Region: SDR_c; cd05233 272620010867 NAD(P) binding site [chemical binding]; other site 272620010868 active site 272620010869 glycine dehydrogenase; Provisional; Region: PRK05367 272620010870 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272620010871 tetramer interface [polypeptide binding]; other site 272620010872 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620010873 catalytic residue [active] 272620010874 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 272620010875 tetramer interface [polypeptide binding]; other site 272620010876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620010877 catalytic residue [active] 272620010878 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272620010879 lipoyl attachment site [posttranslational modification]; other site 272620010880 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 272620010881 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 272620010882 oxidoreductase; Provisional; Region: PRK08013 272620010883 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 272620010884 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 272620010885 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 272620010886 proline aminopeptidase P II; Provisional; Region: PRK10879 272620010887 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 272620010888 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 272620010889 active site 272620010890 hypothetical protein; Reviewed; Region: PRK01736 272620010891 Z-ring-associated protein; Provisional; Region: PRK10972 272620010892 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 272620010893 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272620010894 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 272620010895 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 272620010896 ligand binding site [chemical binding]; other site 272620010897 NAD binding site [chemical binding]; other site 272620010898 tetramer interface [polypeptide binding]; other site 272620010899 catalytic site [active] 272620010900 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 272620010901 L-serine binding site [chemical binding]; other site 272620010902 ACT domain interface; other site 272620010903 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 272620010904 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620010905 active site 272620010906 dimer interface [polypeptide binding]; other site 272620010907 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 272620010908 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620010909 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 272620010910 putative dimerization interface [polypeptide binding]; other site 272620010911 oxidative stress defense protein; Provisional; Region: PRK11087 272620010912 Uncharacterized conserved protein [Function unknown]; Region: COG2968 272620010913 arginine exporter protein; Provisional; Region: PRK09304 272620010914 mechanosensitive channel MscS; Provisional; Region: PRK10334 272620010915 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620010916 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272620010917 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 272620010918 active site 272620010919 intersubunit interface [polypeptide binding]; other site 272620010920 zinc binding site [ion binding]; other site 272620010921 Na+ binding site [ion binding]; other site 272620010922 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272620010923 Phosphoglycerate kinase; Region: PGK; pfam00162 272620010924 substrate binding site [chemical binding]; other site 272620010925 hinge regions; other site 272620010926 ADP binding site [chemical binding]; other site 272620010927 catalytic site [active] 272620010928 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 272620010929 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272620010930 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272620010931 transketolase; Reviewed; Region: PRK12753 272620010932 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272620010933 TPP-binding site [chemical binding]; other site 272620010934 dimer interface [polypeptide binding]; other site 272620010935 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272620010936 PYR/PP interface [polypeptide binding]; other site 272620010937 dimer interface [polypeptide binding]; other site 272620010938 TPP binding site [chemical binding]; other site 272620010939 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272620010940 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 272620010941 outer membrane porin, OprD family; Region: OprD; pfam03573 272620010942 hypothetical protein; Provisional; Region: PRK07064 272620010943 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620010944 PYR/PP interface [polypeptide binding]; other site 272620010945 dimer interface [polypeptide binding]; other site 272620010946 TPP binding site [chemical binding]; other site 272620010947 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620010948 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 272620010949 TPP-binding site [chemical binding]; other site 272620010950 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272620010951 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 272620010952 NAD(P) binding site [chemical binding]; other site 272620010953 catalytic residues [active] 272620010954 L-aspartate dehydrogenase; Provisional; Region: PRK13303 272620010955 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272620010956 Domain of unknown function DUF108; Region: DUF108; pfam01958 272620010957 short chain dehydrogenase; Provisional; Region: PRK07062 272620010958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620010959 NAD(P) binding site [chemical binding]; other site 272620010960 active site 272620010961 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272620010962 D-galactonate transporter; Region: 2A0114; TIGR00893 272620010963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010964 putative substrate translocation pore; other site 272620010965 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 272620010966 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272620010967 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620010968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 272620010969 active site 272620010970 metal binding site [ion binding]; metal-binding site 272620010971 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 272620010972 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620010973 putative active site [active] 272620010974 putative metal binding site [ion binding]; other site 272620010975 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620010976 Transcriptional regulator [Transcription]; Region: IclR; COG1414 272620010977 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620010978 short chain dehydrogenase; Provisional; Region: PRK12939 272620010979 classical (c) SDRs; Region: SDR_c; cd05233 272620010980 NAD(P) binding site [chemical binding]; other site 272620010981 active site 272620010982 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 272620010983 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 272620010984 [2Fe-2S] cluster binding site [ion binding]; other site 272620010985 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 272620010986 hydrophobic ligand binding site; other site 272620010987 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 272620010988 [2Fe-2S] cluster binding site [ion binding]; other site 272620010989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620010990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620010991 putative substrate translocation pore; other site 272620010992 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 272620010993 agmatinase; Region: agmatinase; TIGR01230 272620010994 oligomer interface [polypeptide binding]; other site 272620010995 putative active site [active] 272620010996 Mn binding site [ion binding]; other site 272620010997 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 272620010998 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 272620010999 dimer interface [polypeptide binding]; other site 272620011000 active site 272620011001 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272620011002 catalytic residues [active] 272620011003 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 272620011004 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272620011005 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272620011006 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272620011007 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272620011008 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 272620011009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620011010 putative substrate translocation pore; other site 272620011011 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 272620011012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620011013 hypothetical protein; Provisional; Region: PRK04860 272620011014 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 272620011015 DNA-specific endonuclease I; Provisional; Region: PRK15137 272620011016 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 272620011017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 272620011018 RNA methyltransferase, RsmE family; Region: TIGR00046 272620011019 glutathione synthetase; Provisional; Region: PRK05246 272620011020 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 272620011021 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 272620011022 hypothetical protein; Validated; Region: PRK00228 272620011023 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 272620011024 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 272620011025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620011026 DNA binding residues [nucleotide binding] 272620011027 dimerization interface [polypeptide binding]; other site 272620011028 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 272620011029 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 272620011030 Walker A motif; other site 272620011031 ATP binding site [chemical binding]; other site 272620011032 Walker B motif; other site 272620011033 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 272620011034 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272620011035 catalytic residue [active] 272620011036 YGGT family; Region: YGGT; pfam02325 272620011037 YGGT family; Region: YGGT; pfam02325 272620011038 hypothetical protein; Validated; Region: PRK05090 272620011039 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272620011040 active site 272620011041 dimerization interface [polypeptide binding]; other site 272620011042 HemN family oxidoreductase; Provisional; Region: PRK05660 272620011043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620011044 FeS/SAM binding site; other site 272620011045 HemN C-terminal domain; Region: HemN_C; pfam06969 272620011046 hypothetical protein; Provisional; Region: PRK10626 272620011047 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 272620011048 hypothetical protein; Provisional; Region: PRK11702 272620011049 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272620011050 adenine DNA glycosylase; Provisional; Region: PRK10880 272620011051 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 272620011052 minor groove reading motif; other site 272620011053 helix-hairpin-helix signature motif; other site 272620011054 substrate binding pocket [chemical binding]; other site 272620011055 active site 272620011056 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 272620011057 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 272620011058 DNA binding and oxoG recognition site [nucleotide binding] 272620011059 oxidative damage protection protein; Provisional; Region: PRK05408 272620011060 murein transglycosylase C; Provisional; Region: mltC; PRK11671 272620011061 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 272620011062 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620011063 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620011064 catalytic residue [active] 272620011065 nucleoside transporter; Region: 2A0110; TIGR00889 272620011066 ornithine decarboxylase; Provisional; Region: PRK13578 272620011067 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 272620011068 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 272620011069 homodimer interface [polypeptide binding]; other site 272620011070 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620011071 catalytic residue [active] 272620011072 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 272620011073 Protein of unknown function (DUF554); Region: DUF554; pfam04474 272620011074 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272620011075 active site 272620011076 Int/Topo IB signature motif; other site 272620011077 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620011078 PapC N-terminal domain; Region: PapC_N; pfam13954 272620011079 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620011080 PapC C-terminal domain; Region: PapC_C; pfam13953 272620011081 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 272620011082 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620011083 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620011084 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620011085 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620011086 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620011087 Fimbrial protein; Region: Fimbrial; pfam00419 272620011088 Fimbrial protein; Region: Fimbrial; pfam00419 272620011089 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620011090 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620011091 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620011092 Fimbrial protein; Region: Fimbrial; cl01416 272620011093 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 272620011094 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 272620011095 dimer interface [polypeptide binding]; other site 272620011096 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620011097 catalytic residue [active] 272620011098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 272620011099 FOG: CBS domain [General function prediction only]; Region: COG0517 272620011100 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 272620011101 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272620011102 homodimer interface [polypeptide binding]; other site 272620011103 substrate-cofactor binding pocket; other site 272620011104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620011105 catalytic residue [active] 272620011106 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620011107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620011108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 272620011109 putative effector binding pocket; other site 272620011110 putative dimerization interface [polypeptide binding]; other site 272620011111 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 272620011112 putative NAD(P) binding site [chemical binding]; other site 272620011113 homodimer interface [polypeptide binding]; other site 272620011114 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 272620011115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620011116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620011117 homodimer interface [polypeptide binding]; other site 272620011118 catalytic residue [active] 272620011119 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 272620011120 CHAP domain; Region: CHAP; pfam05257 272620011121 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 272620011122 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272620011123 Thioredoxin; Region: Thioredoxin_4; cl17273 272620011124 putative S-transferase; Provisional; Region: PRK11752 272620011125 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 272620011126 C-terminal domain interface [polypeptide binding]; other site 272620011127 GSH binding site (G-site) [chemical binding]; other site 272620011128 dimer interface [polypeptide binding]; other site 272620011129 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 272620011130 dimer interface [polypeptide binding]; other site 272620011131 N-terminal domain interface [polypeptide binding]; other site 272620011132 active site 272620011133 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 272620011134 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272620011135 hypothetical protein; Provisional; Region: PRK05208 272620011136 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272620011137 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 272620011138 active site 272620011139 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620011140 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 272620011141 biopolymer transport protein ExbD; Provisional; Region: PRK11267 272620011142 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 272620011143 biopolymer transport protein ExbB; Provisional; Region: PRK10414 272620011144 cystathionine beta-lyase; Provisional; Region: PRK08114 272620011145 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272620011146 homodimer interface [polypeptide binding]; other site 272620011147 substrate-cofactor binding pocket; other site 272620011148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620011149 catalytic residue [active] 272620011150 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272620011151 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 272620011152 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 272620011153 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620011154 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620011155 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620011156 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 272620011157 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 272620011158 dimer interface [polypeptide binding]; other site 272620011159 active site 272620011160 metal binding site [ion binding]; metal-binding site 272620011161 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272620011162 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272620011163 active site 272620011164 catalytic tetrad [active] 272620011165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620011166 Coenzyme A binding pocket [chemical binding]; other site 272620011167 hypothetical protein; Provisional; Region: PRK01254 272620011168 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 272620011169 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 272620011170 FtsI repressor; Provisional; Region: PRK10883 272620011171 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272620011172 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272620011173 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272620011174 putative acyl-acceptor binding pocket; other site 272620011175 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 272620011176 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272620011177 CAP-like domain; other site 272620011178 active site 272620011179 primary dimer interface [polypeptide binding]; other site 272620011180 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620011181 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620011182 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 272620011183 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 272620011184 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 272620011185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620011186 active site 272620011187 phosphorylation site [posttranslational modification] 272620011188 intermolecular recognition site; other site 272620011189 dimerization interface [polypeptide binding]; other site 272620011190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620011191 DNA binding site [nucleotide binding] 272620011192 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620011193 dimer interface [polypeptide binding]; other site 272620011194 phosphorylation site [posttranslational modification] 272620011195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620011196 ATP binding site [chemical binding]; other site 272620011197 Mg2+ binding site [ion binding]; other site 272620011198 G-X-G motif; other site 272620011199 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272620011200 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272620011201 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 272620011202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620011203 ATP binding site [chemical binding]; other site 272620011204 Mg2+ binding site [ion binding]; other site 272620011205 G-X-G motif; other site 272620011206 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272620011207 anchoring element; other site 272620011208 dimer interface [polypeptide binding]; other site 272620011209 ATP binding site [chemical binding]; other site 272620011210 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272620011211 active site 272620011212 metal binding site [ion binding]; metal-binding site 272620011213 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272620011214 esterase YqiA; Provisional; Region: PRK11071 272620011215 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272620011216 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 272620011217 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272620011218 hexamer interface [polypeptide binding]; other site 272620011219 active site 272620011220 metal binding site [ion binding]; metal-binding site 272620011221 putative dehydrogenase; Provisional; Region: PRK11039 272620011222 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 272620011223 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272620011224 dimer interface [polypeptide binding]; other site 272620011225 ADP-ribose binding site [chemical binding]; other site 272620011226 active site 272620011227 nudix motif; other site 272620011228 metal binding site [ion binding]; metal-binding site 272620011229 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 272620011230 hypothetical protein; Provisional; Region: PRK11653 272620011231 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 272620011232 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 272620011233 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 272620011234 putative active site [active] 272620011235 metal binding site [ion binding]; metal-binding site 272620011236 zinc transporter ZupT; Provisional; Region: PRK04201 272620011237 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 272620011238 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 272620011239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 272620011240 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 272620011241 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 272620011242 putative ribose interaction site [chemical binding]; other site 272620011243 putative ADP binding site [chemical binding]; other site 272620011244 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 272620011245 active site 272620011246 nucleotide binding site [chemical binding]; other site 272620011247 HIGH motif; other site 272620011248 KMSKS motif; other site 272620011249 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 272620011250 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272620011251 metal binding triad; other site 272620011252 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272620011253 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 272620011254 metal binding triad; other site 272620011255 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 272620011256 Uncharacterized conserved protein [Function unknown]; Region: COG3025 272620011257 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 272620011258 putative active site [active] 272620011259 putative metal binding residues [ion binding]; other site 272620011260 signature motif; other site 272620011261 putative triphosphate binding site [ion binding]; other site 272620011262 SH3 domain-containing protein; Provisional; Region: PRK10884 272620011263 Bacterial SH3 domain homologues; Region: SH3b; smart00287 272620011264 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 272620011265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 272620011266 active site 272620011267 NTP binding site [chemical binding]; other site 272620011268 metal binding triad [ion binding]; metal-binding site 272620011269 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 272620011270 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620011271 Zn2+ binding site [ion binding]; other site 272620011272 Mg2+ binding site [ion binding]; other site 272620011273 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 272620011274 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 272620011275 homooctamer interface [polypeptide binding]; other site 272620011276 active site 272620011277 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272620011278 Urease accessory protein UreH [Posttranslational modification, protein turnover, chaperones]; Region: UreH; COG0829 272620011279 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 272620011280 alpha-gamma subunit interface [polypeptide binding]; other site 272620011281 beta-gamma subunit interface [polypeptide binding]; other site 272620011282 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 272620011283 gamma-beta subunit interface [polypeptide binding]; other site 272620011284 alpha-beta subunit interface [polypeptide binding]; other site 272620011285 urease subunit alpha; Reviewed; Region: ureC; PRK13207 272620011286 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 272620011287 subunit interactions [polypeptide binding]; other site 272620011288 active site 272620011289 flap region; other site 272620011290 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 272620011291 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 272620011292 dimer interface [polypeptide binding]; other site 272620011293 catalytic residues [active] 272620011294 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 272620011295 UreF; Region: UreF; pfam01730 272620011296 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272620011297 UGMP family protein; Validated; Region: PRK09604 272620011298 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272620011299 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272620011300 DNA primase; Validated; Region: dnaG; PRK05667 272620011301 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272620011302 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272620011303 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272620011304 active site 272620011305 metal binding site [ion binding]; metal-binding site 272620011306 interdomain interaction site; other site 272620011307 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 272620011308 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 272620011309 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 272620011310 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 272620011311 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 272620011312 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 272620011313 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272620011314 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272620011315 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272620011316 DNA binding residues [nucleotide binding] 272620011317 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 272620011318 active site 272620011319 SUMO-1 interface [polypeptide binding]; other site 272620011320 phage PhiKPN 272620011321 tail protein; Provisional; Region: D; PHA02561 272620011322 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 272620011323 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 272620011324 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 272620011325 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 272620011326 Phage tail tube protein FII; Region: Phage_tube; cl01390 272620011327 major tail sheath protein; Provisional; Region: FI; PHA02560 272620011328 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 272620011329 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 272620011330 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 272620011331 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 272620011332 baseplate assembly protein; Provisional; Region: J; PHA02568 272620011333 baseplate wedge subunit; Provisional; Region: W; PHA02516 272620011334 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 272620011335 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 272620011336 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 272620011337 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 272620011338 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 272620011339 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 272620011340 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 272620011341 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 272620011342 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620011343 catalytic residue [active] 272620011344 Phage holin family 2; Region: Phage_holin_2; pfam04550 272620011345 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 272620011346 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 272620011347 terminase endonuclease subunit; Provisional; Region: M; PHA02537 272620011348 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 272620011349 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 272620011350 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 272620011351 terminase ATPase subunit; Provisional; Region: P; PHA02535 272620011352 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 272620011353 portal vertex protein; Provisional; Region: Q; PHA02536 272620011354 Phage portal protein; Region: Phage_portal; pfam04860 272620011355 DinI-like family; Region: DinI; pfam06183 272620011356 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 272620011357 DksA-like zinc finger domain containing protein; Region: PHA00080 272620011358 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 272620011359 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 272620011360 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 272620011361 integrase; Provisional; Region: int; PHA02601 272620011362 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 272620011363 dimer interface [polypeptide binding]; other site 272620011364 active site 272620011365 catalytic residues [active] 272620011366 Int/Topo IB signature motif; other site 272620011367 HdeA/HdeB family; Region: HdeA; pfam06411 272620011368 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 272620011369 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620011370 active site 272620011371 phosphorylation site [posttranslational modification] 272620011372 intermolecular recognition site; other site 272620011373 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620011374 DNA binding residues [nucleotide binding] 272620011375 dimerization interface [polypeptide binding]; other site 272620011376 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 272620011377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620011378 substrate binding pocket [chemical binding]; other site 272620011379 membrane-bound complex binding site; other site 272620011380 hinge residues; other site 272620011381 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620011382 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620011383 substrate binding pocket [chemical binding]; other site 272620011384 membrane-bound complex binding site; other site 272620011385 hinge residues; other site 272620011386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 272620011387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620011388 dimer interface [polypeptide binding]; other site 272620011389 phosphorylation site [posttranslational modification] 272620011390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620011391 ATP binding site [chemical binding]; other site 272620011392 Mg2+ binding site [ion binding]; other site 272620011393 G-X-G motif; other site 272620011394 Response regulator receiver domain; Region: Response_reg; pfam00072 272620011395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620011396 active site 272620011397 phosphorylation site [posttranslational modification] 272620011398 intermolecular recognition site; other site 272620011399 dimerization interface [polypeptide binding]; other site 272620011400 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 272620011401 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 272620011402 hypothetical protein; Provisional; Region: PRK10316 272620011403 YfdX protein; Region: YfdX; pfam10938 272620011404 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 272620011405 acid-resistance membrane protein; Provisional; Region: PRK10209 272620011406 acid-resistance protein; Provisional; Region: hdeB; PRK11566 272620011407 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272620011408 amphipathic channel; other site 272620011409 Asn-Pro-Ala signature motifs; other site 272620011410 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 272620011411 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272620011412 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 272620011413 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 272620011414 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 272620011415 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 272620011416 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 272620011417 alpha-beta subunit interface [polypeptide binding]; other site 272620011418 alpha-gamma subunit interface [polypeptide binding]; other site 272620011419 active site 272620011420 substrate and K+ binding site; other site 272620011421 K+ binding site [ion binding]; other site 272620011422 cobalamin binding site [chemical binding]; other site 272620011423 Domain of unknown function (DUF336); Region: DUF336; pfam03928 272620011424 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272620011425 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 272620011426 dimer interface [polypeptide binding]; other site 272620011427 active site 272620011428 metal binding site [ion binding]; metal-binding site 272620011429 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 272620011430 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 272620011431 PAS domain; Region: PAS; smart00091 272620011432 putative active site [active] 272620011433 heme pocket [chemical binding]; other site 272620011434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620011435 Walker A motif; other site 272620011436 ATP binding site [chemical binding]; other site 272620011437 Walker B motif; other site 272620011438 arginine finger; other site 272620011439 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620011440 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 272620011441 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 272620011442 dimer interface [polypeptide binding]; other site 272620011443 active site 272620011444 metal binding site [ion binding]; metal-binding site 272620011445 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 272620011446 Dak1 domain; Region: Dak1; pfam02733 272620011447 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 272620011448 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 272620011449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 272620011450 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272620011451 dimerization domain swap beta strand [polypeptide binding]; other site 272620011452 regulatory protein interface [polypeptide binding]; other site 272620011453 active site 272620011454 regulatory phosphorylation site [posttranslational modification]; other site 272620011455 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272620011456 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272620011457 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 272620011458 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 272620011459 DAK2 domain; Region: Dak2; pfam02734 272620011460 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 272620011461 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 272620011462 FAD binding pocket [chemical binding]; other site 272620011463 FAD binding motif [chemical binding]; other site 272620011464 phosphate binding motif [ion binding]; other site 272620011465 NAD binding pocket [chemical binding]; other site 272620011466 Predicted transcriptional regulators [Transcription]; Region: COG1695 272620011467 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 272620011468 GLE1-like protein; Region: GLE1; pfam07817 272620011469 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 272620011470 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620011471 inhibitor-cofactor binding pocket; inhibition site 272620011472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620011473 catalytic residue [active] 272620011474 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 272620011475 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 272620011476 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 272620011477 putative active site; other site 272620011478 catalytic residue [active] 272620011479 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 272620011480 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272620011481 ligand binding site [chemical binding]; other site 272620011482 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620011483 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620011484 TM-ABC transporter signature motif; other site 272620011485 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620011486 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620011487 TM-ABC transporter signature motif; other site 272620011488 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 272620011489 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620011490 Walker A/P-loop; other site 272620011491 ATP binding site [chemical binding]; other site 272620011492 Q-loop/lid; other site 272620011493 ABC transporter signature motif; other site 272620011494 Walker B; other site 272620011495 D-loop; other site 272620011496 H-loop/switch region; other site 272620011497 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620011498 transcriptional regulator LsrR; Provisional; Region: PRK15418 272620011499 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272620011500 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 272620011501 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 272620011502 putative N- and C-terminal domain interface [polypeptide binding]; other site 272620011503 putative active site [active] 272620011504 putative MgATP binding site [chemical binding]; other site 272620011505 catalytic site [active] 272620011506 metal binding site [ion binding]; metal-binding site 272620011507 putative carbohydrate binding site [chemical binding]; other site 272620011508 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272620011509 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 272620011510 active site 272620011511 FMN binding site [chemical binding]; other site 272620011512 2,4-decadienoyl-CoA binding site; other site 272620011513 catalytic residue [active] 272620011514 4Fe-4S cluster binding site [ion binding]; other site 272620011515 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 272620011516 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620011517 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 272620011518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620011519 S-adenosylmethionine binding site [chemical binding]; other site 272620011520 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 272620011521 B3/4 domain; Region: B3_4; pfam03483 272620011522 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620011523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620011524 non-specific DNA binding site [nucleotide binding]; other site 272620011525 salt bridge; other site 272620011526 sequence-specific DNA binding site [nucleotide binding]; other site 272620011527 Cupin domain; Region: Cupin_2; pfam07883 272620011528 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 272620011529 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620011530 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620011531 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 272620011532 serine/threonine transporter SstT; Provisional; Region: PRK13628 272620011533 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272620011534 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 272620011535 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 272620011536 galactarate dehydratase; Region: galactar-dH20; TIGR03248 272620011537 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 272620011538 Glucuronate isomerase; Region: UxaC; pfam02614 272620011539 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 272620011540 D-galactonate transporter; Region: 2A0114; TIGR00893 272620011541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620011542 putative substrate translocation pore; other site 272620011543 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 272620011544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620011545 DNA-binding site [nucleotide binding]; DNA binding site 272620011546 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272620011547 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 272620011548 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 272620011549 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 272620011550 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 272620011551 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 272620011552 Predicted membrane protein [Function unknown]; Region: COG5393 272620011553 YqjK-like protein; Region: YqjK; pfam13997 272620011554 Predicted membrane protein [Function unknown]; Region: COG2259 272620011555 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 272620011556 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 272620011557 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 272620011558 putative dimer interface [polypeptide binding]; other site 272620011559 N-terminal domain interface [polypeptide binding]; other site 272620011560 putative substrate binding pocket (H-site) [chemical binding]; other site 272620011561 Predicted membrane protein [Function unknown]; Region: COG3152 272620011562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620011563 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 272620011564 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620011565 dimerization interface [polypeptide binding]; other site 272620011566 Pirin-related protein [General function prediction only]; Region: COG1741 272620011567 Pirin; Region: Pirin; pfam02678 272620011568 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 272620011569 dimer interface [polypeptide binding]; other site 272620011570 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 272620011571 glycerate kinase I; Provisional; Region: PRK10342 272620011572 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 272620011573 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272620011574 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 272620011575 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620011576 D-galactonate transporter; Region: 2A0114; TIGR00893 272620011577 putative substrate translocation pore; other site 272620011578 galactarate dehydratase; Region: galactar-dH20; TIGR03248 272620011579 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 272620011580 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 272620011581 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620011582 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272620011583 substrate binding site [chemical binding]; other site 272620011584 ATP binding site [chemical binding]; other site 272620011585 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620011586 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620011587 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620011588 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272620011589 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272620011590 intersubunit interface [polypeptide binding]; other site 272620011591 active site 272620011592 zinc binding site [ion binding]; other site 272620011593 Na+ binding site [ion binding]; other site 272620011594 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272620011595 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272620011596 putative substrate binding site [chemical binding]; other site 272620011597 putative ATP binding site [chemical binding]; other site 272620011598 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 272620011599 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272620011600 active site 272620011601 P-loop; other site 272620011602 phosphorylation site [posttranslational modification] 272620011603 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272620011604 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620011605 active site 272620011606 phosphorylation site [posttranslational modification] 272620011607 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272620011608 dimerization domain swap beta strand [polypeptide binding]; other site 272620011609 regulatory protein interface [polypeptide binding]; other site 272620011610 active site 272620011611 regulatory phosphorylation site [posttranslational modification]; other site 272620011612 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 272620011613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620011614 active site 272620011615 phosphorylation site [posttranslational modification] 272620011616 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 272620011617 active site 272620011618 P-loop; other site 272620011619 phosphorylation site [posttranslational modification] 272620011620 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 272620011621 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 272620011622 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 272620011623 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 272620011624 putative NAD(P) binding site [chemical binding]; other site 272620011625 catalytic Zn binding site [ion binding]; other site 272620011626 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620011627 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620011628 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620011629 Fic family protein [Function unknown]; Region: COG3177 272620011630 Fic/DOC family; Region: Fic; pfam02661 272620011631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620011632 putative DNA binding site [nucleotide binding]; other site 272620011633 putative Zn2+ binding site [ion binding]; other site 272620011634 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 272620011635 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272620011636 putative SAM binding site [chemical binding]; other site 272620011637 putative homodimer interface [polypeptide binding]; other site 272620011638 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272620011639 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 272620011640 putative ligand binding site [chemical binding]; other site 272620011641 hypothetical protein; Reviewed; Region: PRK12497 272620011642 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 272620011643 dimer interface [polypeptide binding]; other site 272620011644 active site 272620011645 outer membrane lipoprotein; Provisional; Region: PRK11023 272620011646 BON domain; Region: BON; pfam04972 272620011647 BON domain; Region: BON; pfam04972 272620011648 Predicted permease; Region: DUF318; pfam03773 272620011649 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 272620011650 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272620011651 NAD binding site [chemical binding]; other site 272620011652 active site 272620011653 intracellular protease, PfpI family; Region: PfpI; TIGR01382 272620011654 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 272620011655 proposed catalytic triad [active] 272620011656 conserved cys residue [active] 272620011657 hypothetical protein; Provisional; Region: PRK03467 272620011658 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 272620011659 GIY-YIG motif/motif A; other site 272620011660 putative active site [active] 272620011661 putative metal binding site [ion binding]; other site 272620011662 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272620011663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620011664 Coenzyme A binding pocket [chemical binding]; other site 272620011665 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 272620011666 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272620011667 Peptidase family U32; Region: Peptidase_U32; pfam01136 272620011668 putative protease; Provisional; Region: PRK15447 272620011669 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272620011670 hypothetical protein; Provisional; Region: PRK10508 272620011671 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 272620011672 tryptophan permease; Provisional; Region: PRK10483 272620011673 aromatic amino acid transport protein; Region: araaP; TIGR00837 272620011674 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272620011675 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272620011676 ATP binding site [chemical binding]; other site 272620011677 Mg++ binding site [ion binding]; other site 272620011678 motif III; other site 272620011679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620011680 nucleotide binding region [chemical binding]; other site 272620011681 ATP-binding site [chemical binding]; other site 272620011682 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 272620011683 putative RNA binding site [nucleotide binding]; other site 272620011684 lipoprotein NlpI; Provisional; Region: PRK11189 272620011685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620011686 binding surface 272620011687 TPR motif; other site 272620011688 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272620011689 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 272620011690 RNase E interface [polypeptide binding]; other site 272620011691 trimer interface [polypeptide binding]; other site 272620011692 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 272620011693 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 272620011694 RNase E interface [polypeptide binding]; other site 272620011695 trimer interface [polypeptide binding]; other site 272620011696 active site 272620011697 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 272620011698 putative nucleic acid binding region [nucleotide binding]; other site 272620011699 G-X-X-G motif; other site 272620011700 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 272620011701 RNA binding site [nucleotide binding]; other site 272620011702 domain interface; other site 272620011703 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272620011704 16S/18S rRNA binding site [nucleotide binding]; other site 272620011705 S13e-L30e interaction site [polypeptide binding]; other site 272620011706 25S rRNA binding site [nucleotide binding]; other site 272620011707 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 272620011708 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272620011709 RNA binding site [nucleotide binding]; other site 272620011710 active site 272620011711 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 272620011712 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272620011713 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272620011714 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 272620011715 translation initiation factor IF-2; Region: IF-2; TIGR00487 272620011716 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272620011717 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272620011718 G1 box; other site 272620011719 putative GEF interaction site [polypeptide binding]; other site 272620011720 GTP/Mg2+ binding site [chemical binding]; other site 272620011721 Switch I region; other site 272620011722 G2 box; other site 272620011723 G3 box; other site 272620011724 Switch II region; other site 272620011725 G4 box; other site 272620011726 G5 box; other site 272620011727 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272620011728 Translation-initiation factor 2; Region: IF-2; pfam11987 272620011729 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272620011730 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272620011731 NusA N-terminal domain; Region: NusA_N; pfam08529 272620011732 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272620011733 RNA binding site [nucleotide binding]; other site 272620011734 homodimer interface [polypeptide binding]; other site 272620011735 NusA-like KH domain; Region: KH_5; pfam13184 272620011736 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272620011737 G-X-X-G motif; other site 272620011738 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272620011739 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 272620011740 ribosome maturation protein RimP; Reviewed; Region: PRK00092 272620011741 Sm and related proteins; Region: Sm_like; cl00259 272620011742 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272620011743 putative oligomer interface [polypeptide binding]; other site 272620011744 putative RNA binding site [nucleotide binding]; other site 272620011745 argininosuccinate synthase; Validated; Region: PRK05370 272620011746 argininosuccinate synthase; Provisional; Region: PRK13820 272620011747 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 272620011748 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 272620011749 ligand binding site [chemical binding]; other site 272620011750 flexible hinge region; other site 272620011751 YfaZ precursor; Region: YfaZ; pfam07437 272620011752 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 272620011753 Preprotein translocase SecG subunit; Region: SecG; pfam03840 272620011754 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 272620011755 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 272620011756 active site 272620011757 substrate binding site [chemical binding]; other site 272620011758 metal binding site [ion binding]; metal-binding site 272620011759 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272620011760 dihydropteroate synthase; Region: DHPS; TIGR01496 272620011761 substrate binding pocket [chemical binding]; other site 272620011762 dimer interface [polypeptide binding]; other site 272620011763 inhibitor binding site; inhibition site 272620011764 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 272620011765 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620011766 Walker A motif; other site 272620011767 ATP binding site [chemical binding]; other site 272620011768 Walker B motif; other site 272620011769 arginine finger; other site 272620011770 Peptidase family M41; Region: Peptidase_M41; pfam01434 272620011771 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 272620011772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620011773 S-adenosylmethionine binding site [chemical binding]; other site 272620011774 RNA-binding protein YhbY; Provisional; Region: PRK10343 272620011775 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272620011776 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272620011777 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272620011778 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 272620011779 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 272620011780 GTPase CgtA; Reviewed; Region: obgE; PRK12298 272620011781 GTP1/OBG; Region: GTP1_OBG; pfam01018 272620011782 Obg GTPase; Region: Obg; cd01898 272620011783 G1 box; other site 272620011784 GTP/Mg2+ binding site [chemical binding]; other site 272620011785 Switch I region; other site 272620011786 G2 box; other site 272620011787 G3 box; other site 272620011788 Switch II region; other site 272620011789 G4 box; other site 272620011790 G5 box; other site 272620011791 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272620011792 EamA-like transporter family; Region: EamA; pfam00892 272620011793 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272620011794 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 272620011795 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272620011796 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 272620011797 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 272620011798 substrate binding pocket [chemical binding]; other site 272620011799 chain length determination region; other site 272620011800 substrate-Mg2+ binding site; other site 272620011801 catalytic residues [active] 272620011802 aspartate-rich region 1; other site 272620011803 active site lid residues [active] 272620011804 aspartate-rich region 2; other site 272620011805 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 272620011806 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 272620011807 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 272620011808 hinge; other site 272620011809 active site 272620011810 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 272620011811 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 272620011812 anti sigma factor interaction site; other site 272620011813 regulatory phosphorylation site [posttranslational modification]; other site 272620011814 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 272620011815 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 272620011816 mce related protein; Region: MCE; pfam02470 272620011817 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 272620011818 conserved hypothetical integral membrane protein; Region: TIGR00056 272620011819 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 272620011820 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 272620011821 Walker A/P-loop; other site 272620011822 ATP binding site [chemical binding]; other site 272620011823 Q-loop/lid; other site 272620011824 ABC transporter signature motif; other site 272620011825 Walker B; other site 272620011826 D-loop; other site 272620011827 H-loop/switch region; other site 272620011828 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 272620011829 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272620011830 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 272620011831 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 272620011832 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 272620011833 putative active site [active] 272620011834 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 272620011835 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 272620011836 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 272620011837 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 272620011838 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 272620011839 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 272620011840 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 272620011841 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 272620011842 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 272620011843 Walker A/P-loop; other site 272620011844 ATP binding site [chemical binding]; other site 272620011845 Q-loop/lid; other site 272620011846 ABC transporter signature motif; other site 272620011847 Walker B; other site 272620011848 D-loop; other site 272620011849 H-loop/switch region; other site 272620011850 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 272620011851 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 272620011852 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 272620011853 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 272620011854 30S subunit binding site; other site 272620011855 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620011856 active site 272620011857 phosphorylation site [posttranslational modification] 272620011858 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 272620011859 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272620011860 dimerization domain swap beta strand [polypeptide binding]; other site 272620011861 regulatory protein interface [polypeptide binding]; other site 272620011862 active site 272620011863 regulatory phosphorylation site [posttranslational modification]; other site 272620011864 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 272620011865 Transglycosylase; Region: Transgly; cl17702 272620011866 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 272620011867 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 272620011868 conserved cys residue [active] 272620011869 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 272620011870 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 272620011871 putative active site [active] 272620011872 heme pocket [chemical binding]; other site 272620011873 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620011874 dimer interface [polypeptide binding]; other site 272620011875 phosphorylation site [posttranslational modification] 272620011876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620011877 ATP binding site [chemical binding]; other site 272620011878 Mg2+ binding site [ion binding]; other site 272620011879 G-X-G motif; other site 272620011880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620011881 active site 272620011882 phosphorylation site [posttranslational modification] 272620011883 intermolecular recognition site; other site 272620011884 dimerization interface [polypeptide binding]; other site 272620011885 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 272620011886 putative binding surface; other site 272620011887 active site 272620011888 mannonate dehydratase; Provisional; Region: PRK03906 272620011889 mannonate dehydratase; Region: uxuA; TIGR00695 272620011890 putative oxidoreductase; Provisional; Region: PRK10083 272620011891 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 272620011892 putative NAD(P) binding site [chemical binding]; other site 272620011893 catalytic Zn binding site [ion binding]; other site 272620011894 structural Zn binding site [ion binding]; other site 272620011895 D-galactonate transporter; Region: 2A0114; TIGR00893 272620011896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620011897 putative substrate translocation pore; other site 272620011898 radical SAM protein, TIGR01212 family; Region: TIGR01212 272620011899 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620011900 FeS/SAM binding site; other site 272620011901 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 272620011902 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 272620011903 active site 272620011904 dimer interface [polypeptide binding]; other site 272620011905 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 272620011906 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 272620011907 active site 272620011908 FMN binding site [chemical binding]; other site 272620011909 substrate binding site [chemical binding]; other site 272620011910 3Fe-4S cluster binding site [ion binding]; other site 272620011911 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 272620011912 domain interface; other site 272620011913 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 272620011914 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272620011915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620011916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620011917 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 272620011918 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272620011919 putative active site cavity [active] 272620011920 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 272620011921 stringent starvation protein A; Provisional; Region: sspA; PRK09481 272620011922 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 272620011923 C-terminal domain interface [polypeptide binding]; other site 272620011924 putative GSH binding site (G-site) [chemical binding]; other site 272620011925 dimer interface [polypeptide binding]; other site 272620011926 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 272620011927 dimer interface [polypeptide binding]; other site 272620011928 N-terminal domain interface [polypeptide binding]; other site 272620011929 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272620011930 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272620011931 23S rRNA interface [nucleotide binding]; other site 272620011932 L3 interface [polypeptide binding]; other site 272620011933 Predicted ATPase [General function prediction only]; Region: COG1485 272620011934 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 272620011935 hypothetical protein; Provisional; Region: PRK11677 272620011936 serine endoprotease; Provisional; Region: PRK10139 272620011937 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272620011938 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272620011939 protein binding site [polypeptide binding]; other site 272620011940 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272620011941 serine endoprotease; Provisional; Region: PRK10898 272620011942 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 272620011943 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 272620011944 protein binding site [polypeptide binding]; other site 272620011945 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 272620011946 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 272620011947 oxaloacetate decarboxylase; Provisional; Region: PRK14040 272620011948 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 272620011949 active site 272620011950 catalytic residues [active] 272620011951 metal binding site [ion binding]; metal-binding site 272620011952 homodimer binding site [polypeptide binding]; other site 272620011953 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272620011954 carboxyltransferase (CT) interaction site; other site 272620011955 biotinylation site [posttranslational modification]; other site 272620011956 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 272620011957 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 272620011958 Citrate transporter; Region: CitMHS; pfam03600 272620011959 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 272620011960 transmembrane helices; other site 272620011961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620011962 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 272620011963 DNA-binding site [nucleotide binding]; DNA binding site 272620011964 FCD domain; Region: FCD; pfam07729 272620011965 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272620011966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620011967 DNA-binding site [nucleotide binding]; DNA binding site 272620011968 malate dehydrogenase; Provisional; Region: PRK05086 272620011969 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 272620011970 NAD binding site [chemical binding]; other site 272620011971 dimerization interface [polypeptide binding]; other site 272620011972 Substrate binding site [chemical binding]; other site 272620011973 arginine repressor; Provisional; Region: PRK05066 272620011974 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 272620011975 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 272620011976 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620011977 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 272620011978 RNAase interaction site [polypeptide binding]; other site 272620011979 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 272620011980 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272620011981 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 272620011982 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 272620011983 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620011984 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620011985 efflux system membrane protein; Provisional; Region: PRK11594 272620011986 transcriptional regulator; Provisional; Region: PRK10632 272620011987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620011988 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 272620011989 putative effector binding pocket; other site 272620011990 dimerization interface [polypeptide binding]; other site 272620011991 protease TldD; Provisional; Region: tldD; PRK10735 272620011992 hypothetical protein; Provisional; Region: PRK10899 272620011993 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272620011994 ribonuclease G; Provisional; Region: PRK11712 272620011995 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 272620011996 homodimer interface [polypeptide binding]; other site 272620011997 oligonucleotide binding site [chemical binding]; other site 272620011998 Maf-like protein; Region: Maf; pfam02545 272620011999 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 272620012000 active site 272620012001 dimer interface [polypeptide binding]; other site 272620012002 rod shape-determining protein MreD; Provisional; Region: PRK11060 272620012003 rod shape-determining protein MreC; Region: mreC; TIGR00219 272620012004 rod shape-determining protein MreC; Region: MreC; pfam04085 272620012005 rod shape-determining protein MreB; Provisional; Region: PRK13927 272620012006 MreB and similar proteins; Region: MreB_like; cd10225 272620012007 nucleotide binding site [chemical binding]; other site 272620012008 Mg binding site [ion binding]; other site 272620012009 putative protofilament interaction site [polypeptide binding]; other site 272620012010 RodZ interaction site [polypeptide binding]; other site 272620012011 regulatory protein CsrD; Provisional; Region: PRK11059 272620012012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620012013 metal binding site [ion binding]; metal-binding site 272620012014 active site 272620012015 I-site; other site 272620012016 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620012017 TMAO/DMSO reductase; Reviewed; Region: PRK05363 272620012018 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 272620012019 Moco binding site; other site 272620012020 metal coordination site [ion binding]; other site 272620012021 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 272620012022 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 272620012023 Dehydroquinase class II; Region: DHquinase_II; pfam01220 272620012024 active site 272620012025 trimer interface [polypeptide binding]; other site 272620012026 dimer interface [polypeptide binding]; other site 272620012027 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 272620012028 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 272620012029 carboxyltransferase (CT) interaction site; other site 272620012030 biotinylation site [posttranslational modification]; other site 272620012031 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 272620012032 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 272620012033 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 272620012034 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 272620012035 hypothetical protein; Provisional; Region: PRK10633 272620012036 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 272620012037 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 272620012038 Na binding site [ion binding]; other site 272620012039 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 272620012040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272620012041 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 272620012042 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272620012043 FMN binding site [chemical binding]; other site 272620012044 active site 272620012045 catalytic residues [active] 272620012046 substrate binding site [chemical binding]; other site 272620012047 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 272620012048 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 272620012049 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 272620012050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620012051 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 272620012052 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 272620012053 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620012054 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620012055 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 272620012056 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272620012057 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 272620012058 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 272620012059 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 272620012060 trimer interface [polypeptide binding]; other site 272620012061 putative metal binding site [ion binding]; other site 272620012062 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 272620012063 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 272620012064 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272620012065 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272620012066 shikimate binding site; other site 272620012067 NAD(P) binding site [chemical binding]; other site 272620012068 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 272620012069 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272620012070 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 272620012071 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272620012072 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272620012073 hypothetical protein; Validated; Region: PRK03430 272620012074 hypothetical protein; Provisional; Region: PRK10736 272620012075 DNA protecting protein DprA; Region: dprA; TIGR00732 272620012076 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272620012077 active site 272620012078 catalytic residues [active] 272620012079 metal binding site [ion binding]; metal-binding site 272620012080 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272620012081 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272620012082 putative active site [active] 272620012083 substrate binding site [chemical binding]; other site 272620012084 putative cosubstrate binding site; other site 272620012085 catalytic site [active] 272620012086 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272620012087 substrate binding site [chemical binding]; other site 272620012088 16S rRNA methyltransferase B; Provisional; Region: PRK10901 272620012089 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 272620012090 putative RNA binding site [nucleotide binding]; other site 272620012091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620012092 S-adenosylmethionine binding site [chemical binding]; other site 272620012093 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 272620012094 TrkA-N domain; Region: TrkA_N; pfam02254 272620012095 TrkA-C domain; Region: TrkA_C; pfam02080 272620012096 TrkA-N domain; Region: TrkA_N; pfam02254 272620012097 TrkA-C domain; Region: TrkA_C; pfam02080 272620012098 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 272620012099 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272620012100 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 272620012101 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 272620012102 DNA binding residues [nucleotide binding] 272620012103 dimer interface [polypeptide binding]; other site 272620012104 metal binding site [ion binding]; metal-binding site 272620012105 hypothetical protein; Provisional; Region: PRK10203 272620012106 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272620012107 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272620012108 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272620012109 alphaNTD homodimer interface [polypeptide binding]; other site 272620012110 alphaNTD - beta interaction site [polypeptide binding]; other site 272620012111 alphaNTD - beta' interaction site [polypeptide binding]; other site 272620012112 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272620012113 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272620012114 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272620012115 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620012116 RNA binding surface [nucleotide binding]; other site 272620012117 30S ribosomal protein S11; Validated; Region: PRK05309 272620012118 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272620012119 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272620012120 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272620012121 SecY translocase; Region: SecY; pfam00344 272620012122 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272620012123 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 272620012124 23S rRNA binding site [nucleotide binding]; other site 272620012125 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272620012126 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272620012127 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272620012128 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272620012129 23S rRNA interface [nucleotide binding]; other site 272620012130 5S rRNA interface [nucleotide binding]; other site 272620012131 L27 interface [polypeptide binding]; other site 272620012132 L5 interface [polypeptide binding]; other site 272620012133 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272620012134 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272620012135 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272620012136 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272620012137 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 272620012138 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272620012139 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272620012140 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272620012141 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272620012142 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272620012143 RNA binding site [nucleotide binding]; other site 272620012144 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272620012145 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272620012146 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272620012147 23S rRNA interface [nucleotide binding]; other site 272620012148 putative translocon interaction site; other site 272620012149 signal recognition particle (SRP54) interaction site; other site 272620012150 L23 interface [polypeptide binding]; other site 272620012151 trigger factor interaction site; other site 272620012152 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272620012153 23S rRNA interface [nucleotide binding]; other site 272620012154 5S rRNA interface [nucleotide binding]; other site 272620012155 putative antibiotic binding site [chemical binding]; other site 272620012156 L25 interface [polypeptide binding]; other site 272620012157 L27 interface [polypeptide binding]; other site 272620012158 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272620012159 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272620012160 G-X-X-G motif; other site 272620012161 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272620012162 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272620012163 protein-rRNA interface [nucleotide binding]; other site 272620012164 putative translocon binding site; other site 272620012165 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272620012166 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272620012167 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272620012168 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272620012169 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272620012170 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272620012171 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 272620012172 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272620012173 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 272620012174 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 272620012175 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 272620012176 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 272620012177 heme binding site [chemical binding]; other site 272620012178 ferroxidase diiron center [ion binding]; other site 272620012179 ferroxidase pore; other site 272620012180 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 272620012181 elongation factor Tu; Reviewed; Region: PRK00049 272620012182 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272620012183 G1 box; other site 272620012184 GEF interaction site [polypeptide binding]; other site 272620012185 GTP/Mg2+ binding site [chemical binding]; other site 272620012186 Switch I region; other site 272620012187 G2 box; other site 272620012188 G3 box; other site 272620012189 Switch II region; other site 272620012190 G4 box; other site 272620012191 G5 box; other site 272620012192 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272620012193 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272620012194 Antibiotic Binding Site [chemical binding]; other site 272620012195 elongation factor G; Reviewed; Region: PRK00007 272620012196 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272620012197 G1 box; other site 272620012198 putative GEF interaction site [polypeptide binding]; other site 272620012199 GTP/Mg2+ binding site [chemical binding]; other site 272620012200 Switch I region; other site 272620012201 G2 box; other site 272620012202 G3 box; other site 272620012203 Switch II region; other site 272620012204 G4 box; other site 272620012205 G5 box; other site 272620012206 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272620012207 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272620012208 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272620012209 30S ribosomal protein S7; Validated; Region: PRK05302 272620012210 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272620012211 S17 interaction site [polypeptide binding]; other site 272620012212 S8 interaction site; other site 272620012213 16S rRNA interaction site [nucleotide binding]; other site 272620012214 streptomycin interaction site [chemical binding]; other site 272620012215 23S rRNA interaction site [nucleotide binding]; other site 272620012216 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272620012217 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 272620012218 sulfur relay protein TusC; Validated; Region: PRK00211 272620012219 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 272620012220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 272620012221 YheO-like PAS domain; Region: PAS_6; pfam08348 272620012222 HTH domain; Region: HTH_22; pfam13309 272620012223 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 272620012224 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 272620012225 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272620012226 phi X174 lysis protein; Provisional; Region: PRK02793 272620012227 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 272620012228 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272620012229 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 272620012230 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 272620012231 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 272620012232 TrkA-N domain; Region: TrkA_N; pfam02254 272620012233 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 272620012234 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 272620012235 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620012236 Walker A/P-loop; other site 272620012237 ATP binding site [chemical binding]; other site 272620012238 Q-loop/lid; other site 272620012239 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620012240 ABC transporter signature motif; other site 272620012241 Walker B; other site 272620012242 D-loop; other site 272620012243 ABC transporter; Region: ABC_tran_2; pfam12848 272620012244 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620012245 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272620012246 putative hydrolase; Provisional; Region: PRK10985 272620012247 hypothetical protein; Provisional; Region: PRK04966 272620012248 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 272620012249 active site 272620012250 hypothetical protein; Provisional; Region: PRK10738 272620012251 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 272620012252 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 272620012253 ligand binding site [chemical binding]; other site 272620012254 flexible hinge region; other site 272620012255 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 272620012256 putative switch regulator; other site 272620012257 non-specific DNA interactions [nucleotide binding]; other site 272620012258 DNA binding site [nucleotide binding] 272620012259 sequence specific DNA binding site [nucleotide binding]; other site 272620012260 putative cAMP binding site [chemical binding]; other site 272620012261 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 272620012262 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 272620012263 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 272620012264 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 272620012265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620012266 inhibitor-cofactor binding pocket; inhibition site 272620012267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620012268 catalytic residue [active] 272620012269 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 272620012270 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 272620012271 glutamine binding [chemical binding]; other site 272620012272 catalytic triad [active] 272620012273 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 272620012274 cell filamentation protein Fic; Provisional; Region: PRK10347 272620012275 hypothetical protein; Provisional; Region: PRK10204 272620012276 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 272620012277 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 272620012278 substrate binding site [chemical binding]; other site 272620012279 putative transporter; Provisional; Region: PRK03699 272620012280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012281 putative substrate translocation pore; other site 272620012282 cytosine deaminase; Provisional; Region: PRK09230 272620012283 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 272620012284 active site 272620012285 nitrite reductase subunit NirD; Provisional; Region: PRK14989 272620012286 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620012287 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 272620012288 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 272620012289 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 272620012290 siroheme synthase; Provisional; Region: cysG; PRK10637 272620012291 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 272620012292 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 272620012293 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 272620012294 active site 272620012295 SAM binding site [chemical binding]; other site 272620012296 homodimer interface [polypeptide binding]; other site 272620012297 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272620012298 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272620012299 active site 272620012300 HIGH motif; other site 272620012301 dimer interface [polypeptide binding]; other site 272620012302 KMSKS motif; other site 272620012303 phosphoglycolate phosphatase; Provisional; Region: PRK13222 272620012304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620012305 motif II; other site 272620012306 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272620012307 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 272620012308 substrate binding site [chemical binding]; other site 272620012309 hexamer interface [polypeptide binding]; other site 272620012310 metal binding site [ion binding]; metal-binding site 272620012311 DNA adenine methylase; Provisional; Region: PRK10904 272620012312 cell division protein DamX; Validated; Region: PRK10905 272620012313 hypothetical protein; Reviewed; Region: PRK11901 272620012314 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 272620012315 active site 272620012316 dimer interface [polypeptide binding]; other site 272620012317 metal binding site [ion binding]; metal-binding site 272620012318 shikimate kinase; Reviewed; Region: aroK; PRK00131 272620012319 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 272620012320 ADP binding site [chemical binding]; other site 272620012321 magnesium binding site [ion binding]; other site 272620012322 putative shikimate binding site; other site 272620012323 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 272620012324 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 272620012325 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 272620012326 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 272620012327 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 272620012328 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 272620012329 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 272620012330 Transglycosylase; Region: Transgly; pfam00912 272620012331 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 272620012332 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 272620012333 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272620012334 ADP-ribose binding site [chemical binding]; other site 272620012335 dimer interface [polypeptide binding]; other site 272620012336 active site 272620012337 nudix motif; other site 272620012338 metal binding site [ion binding]; metal-binding site 272620012339 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 272620012340 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272620012341 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620012342 motif II; other site 272620012343 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620012344 RNA binding surface [nucleotide binding]; other site 272620012345 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272620012346 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 272620012347 dimerization interface [polypeptide binding]; other site 272620012348 domain crossover interface; other site 272620012349 redox-dependent activation switch; other site 272620012350 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 272620012351 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 272620012352 active site 272620012353 substrate-binding site [chemical binding]; other site 272620012354 metal-binding site [ion binding] 272620012355 ATP binding site [chemical binding]; other site 272620012356 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 272620012357 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620012358 dimerization interface [polypeptide binding]; other site 272620012359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620012360 dimer interface [polypeptide binding]; other site 272620012361 phosphorylation site [posttranslational modification] 272620012362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620012363 ATP binding site [chemical binding]; other site 272620012364 Mg2+ binding site [ion binding]; other site 272620012365 G-X-G motif; other site 272620012366 osmolarity response regulator; Provisional; Region: ompR; PRK09468 272620012367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620012368 active site 272620012369 phosphorylation site [posttranslational modification] 272620012370 intermolecular recognition site; other site 272620012371 dimerization interface [polypeptide binding]; other site 272620012372 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620012373 DNA binding site [nucleotide binding] 272620012374 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 272620012375 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272620012376 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272620012377 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 272620012378 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 272620012379 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 272620012380 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 272620012381 RNA binding site [nucleotide binding]; other site 272620012382 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 272620012383 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 272620012384 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 272620012385 G1 box; other site 272620012386 GTP/Mg2+ binding site [chemical binding]; other site 272620012387 Switch I region; other site 272620012388 G2 box; other site 272620012389 G3 box; other site 272620012390 Switch II region; other site 272620012391 G4 box; other site 272620012392 G5 box; other site 272620012393 Nucleoside recognition; Region: Gate; pfam07670 272620012394 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 272620012395 Nucleoside recognition; Region: Gate; pfam07670 272620012396 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 272620012397 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620012398 carboxylesterase BioH; Provisional; Region: PRK10349 272620012399 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 272620012400 catalytic site [active] 272620012401 DNA utilization protein GntX; Provisional; Region: PRK11595 272620012402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620012403 active site 272620012404 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 272620012405 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 272620012406 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 272620012407 high-affinity gluconate transporter; Provisional; Region: PRK14984 272620012408 gluconate transporter; Region: gntP; TIGR00791 272620012409 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 272620012410 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 272620012411 maltodextrin phosphorylase; Provisional; Region: PRK14985 272620012412 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272620012413 homodimer interface [polypeptide binding]; other site 272620012414 active site pocket [active] 272620012415 transcriptional regulator MalT; Provisional; Region: PRK04841 272620012416 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272620012417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620012418 DNA binding residues [nucleotide binding] 272620012419 dimerization interface [polypeptide binding]; other site 272620012420 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 272620012421 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272620012422 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620012423 intramembrane serine protease GlpG; Provisional; Region: PRK10907 272620012424 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 272620012425 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 272620012426 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 272620012427 active site residue [active] 272620012428 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 272620012429 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 272620012430 glycogen phosphorylase; Provisional; Region: PRK14986 272620012431 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 272620012432 homodimer interface [polypeptide binding]; other site 272620012433 active site pocket [active] 272620012434 glycogen synthase; Provisional; Region: glgA; PRK00654 272620012435 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 272620012436 ADP-binding pocket [chemical binding]; other site 272620012437 homodimer interface [polypeptide binding]; other site 272620012438 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 272620012439 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 272620012440 ligand binding site; other site 272620012441 oligomer interface; other site 272620012442 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 272620012443 dimer interface [polypeptide binding]; other site 272620012444 N-terminal domain interface [polypeptide binding]; other site 272620012445 sulfate 1 binding site; other site 272620012446 glycogen debranching enzyme; Provisional; Region: PRK03705 272620012447 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 272620012448 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 272620012449 active site 272620012450 catalytic site [active] 272620012451 glycogen branching enzyme; Provisional; Region: PRK05402 272620012452 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 272620012453 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 272620012454 active site 272620012455 catalytic site [active] 272620012456 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 272620012457 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 272620012458 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272620012459 low affinity gluconate transporter; Provisional; Region: PRK10472 272620012460 gluconate transporter; Region: gntP; TIGR00791 272620012461 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 272620012462 ATP-binding site [chemical binding]; other site 272620012463 Gluconate-6-phosphate binding site [chemical binding]; other site 272620012464 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 272620012465 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620012466 DNA binding site [nucleotide binding] 272620012467 domain linker motif; other site 272620012468 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 272620012469 putative ligand binding site [chemical binding]; other site 272620012470 putative dimerization interface [polypeptide binding]; other site 272620012471 Pirin-related protein [General function prediction only]; Region: COG1741 272620012472 Pirin; Region: Pirin; pfam02678 272620012473 putative oxidoreductase; Provisional; Region: PRK10206 272620012474 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620012475 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620012476 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 272620012477 putative acetyltransferase YhhY; Provisional; Region: PRK10140 272620012478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620012479 Coenzyme A binding pocket [chemical binding]; other site 272620012480 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 272620012481 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 272620012482 Protein of unknown function (DUF2756); Region: DUF2756; pfam10956 272620012483 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 272620012484 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 272620012485 putative active site [active] 272620012486 catalytic site [active] 272620012487 putative metal binding site [ion binding]; other site 272620012488 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272620012489 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272620012490 Walker A/P-loop; other site 272620012491 ATP binding site [chemical binding]; other site 272620012492 Q-loop/lid; other site 272620012493 ABC transporter signature motif; other site 272620012494 Walker B; other site 272620012495 D-loop; other site 272620012496 H-loop/switch region; other site 272620012497 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272620012498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620012499 dimer interface [polypeptide binding]; other site 272620012500 conserved gate region; other site 272620012501 putative PBP binding loops; other site 272620012502 ABC-ATPase subunit interface; other site 272620012503 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 272620012504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620012505 dimer interface [polypeptide binding]; other site 272620012506 conserved gate region; other site 272620012507 putative PBP binding loops; other site 272620012508 ABC-ATPase subunit interface; other site 272620012509 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 272620012510 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 272620012511 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 272620012512 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272620012513 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 272620012514 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 272620012515 Walker A/P-loop; other site 272620012516 ATP binding site [chemical binding]; other site 272620012517 Q-loop/lid; other site 272620012518 ABC transporter signature motif; other site 272620012519 Walker B; other site 272620012520 D-loop; other site 272620012521 H-loop/switch region; other site 272620012522 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 272620012523 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 272620012524 Walker A/P-loop; other site 272620012525 ATP binding site [chemical binding]; other site 272620012526 Q-loop/lid; other site 272620012527 ABC transporter signature motif; other site 272620012528 Walker B; other site 272620012529 D-loop; other site 272620012530 H-loop/switch region; other site 272620012531 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 272620012532 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 272620012533 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 272620012534 TM-ABC transporter signature motif; other site 272620012535 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620012536 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 272620012537 TM-ABC transporter signature motif; other site 272620012538 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272620012539 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 272620012540 dimerization interface [polypeptide binding]; other site 272620012541 ligand binding site [chemical binding]; other site 272620012542 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 272620012543 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 272620012544 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 272620012545 dimerization interface [polypeptide binding]; other site 272620012546 ligand binding site [chemical binding]; other site 272620012547 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 272620012548 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 272620012549 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272620012550 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272620012551 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272620012552 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 272620012553 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 272620012554 inhibitor-cofactor binding pocket; inhibition site 272620012555 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620012556 catalytic residue [active] 272620012557 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620012558 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620012559 DNA-binding site [nucleotide binding]; DNA binding site 272620012560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620012561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620012562 homodimer interface [polypeptide binding]; other site 272620012563 catalytic residue [active] 272620012564 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 272620012565 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272620012566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272620012567 DNA binding residues [nucleotide binding] 272620012568 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 272620012569 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 272620012570 cell division protein FtsE; Provisional; Region: PRK10908 272620012571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620012572 Walker A/P-loop; other site 272620012573 ATP binding site [chemical binding]; other site 272620012574 Q-loop/lid; other site 272620012575 ABC transporter signature motif; other site 272620012576 Walker B; other site 272620012577 D-loop; other site 272620012578 H-loop/switch region; other site 272620012579 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272620012580 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272620012581 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272620012582 P loop; other site 272620012583 GTP binding site [chemical binding]; other site 272620012584 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 272620012585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620012586 S-adenosylmethionine binding site [chemical binding]; other site 272620012587 hypothetical protein; Provisional; Region: PRK10910 272620012588 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 272620012589 Predicted membrane protein [Function unknown]; Region: COG3714 272620012590 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 272620012591 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272620012592 metal-binding site [ion binding] 272620012593 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620012594 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272620012595 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 272620012596 CPxP motif; other site 272620012597 hypothetical protein; Provisional; Region: PRK11212 272620012598 hypothetical protein; Provisional; Region: PRK11615 272620012599 major facilitator superfamily transporter; Provisional; Region: PRK05122 272620012600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012601 putative substrate translocation pore; other site 272620012602 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 272620012603 Domain of unknown function DUF20; Region: UPF0118; pfam01594 272620012604 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 272620012605 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 272620012606 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 272620012607 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 272620012608 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 272620012609 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 272620012610 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 272620012611 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 272620012612 substrate binding site [chemical binding]; other site 272620012613 cosubstrate binding site; other site 272620012614 catalytic site [active] 272620012615 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 272620012616 active site 272620012617 hexamer interface [polypeptide binding]; other site 272620012618 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 272620012619 NAD binding site [chemical binding]; other site 272620012620 substrate binding site [chemical binding]; other site 272620012621 active site 272620012622 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 272620012623 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 272620012624 Ligand binding site; other site 272620012625 Putative Catalytic site; other site 272620012626 DXD motif; other site 272620012627 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272620012628 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272620012629 inhibitor-cofactor binding pocket; inhibition site 272620012630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620012631 catalytic residue [active] 272620012632 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 272620012633 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620012634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620012635 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620012636 dimerization interface [polypeptide binding]; other site 272620012637 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 272620012638 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620012639 substrate binding site [chemical binding]; other site 272620012640 nickel transporter permease NikB; Provisional; Region: PRK10352 272620012641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620012642 dimer interface [polypeptide binding]; other site 272620012643 conserved gate region; other site 272620012644 putative PBP binding loops; other site 272620012645 ABC-ATPase subunit interface; other site 272620012646 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 272620012647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620012648 dimer interface [polypeptide binding]; other site 272620012649 conserved gate region; other site 272620012650 putative PBP binding loops; other site 272620012651 ABC-ATPase subunit interface; other site 272620012652 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 272620012653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620012654 Walker A/P-loop; other site 272620012655 ATP binding site [chemical binding]; other site 272620012656 Q-loop/lid; other site 272620012657 ABC transporter signature motif; other site 272620012658 Walker B; other site 272620012659 D-loop; other site 272620012660 H-loop/switch region; other site 272620012661 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 272620012662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620012663 Walker A/P-loop; other site 272620012664 ATP binding site [chemical binding]; other site 272620012665 Q-loop/lid; other site 272620012666 ABC transporter signature motif; other site 272620012667 Walker B; other site 272620012668 D-loop; other site 272620012669 H-loop/switch region; other site 272620012670 nickel responsive regulator; Provisional; Region: PRK02967 272620012671 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 272620012672 FOG: CBS domain [General function prediction only]; Region: COG0517 272620012673 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272620012674 Divalent cation transporter; Region: MgtE; pfam01769 272620012675 Predicted flavoproteins [General function prediction only]; Region: COG2081 272620012676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620012677 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272620012678 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 272620012679 universal stress protein UspB; Provisional; Region: PRK04960 272620012680 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620012681 Ligand Binding Site [chemical binding]; other site 272620012682 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 272620012683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012684 putative substrate translocation pore; other site 272620012685 POT family; Region: PTR2; pfam00854 272620012686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620012687 S-adenosylmethionine binding site [chemical binding]; other site 272620012688 oligopeptidase A; Provisional; Region: PRK10911 272620012689 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 272620012690 active site 272620012691 Zn binding site [ion binding]; other site 272620012692 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 272620012693 active site 272620012694 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 272620012695 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 272620012696 glutathione reductase; Validated; Region: PRK06116 272620012697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620012698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620012699 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272620012700 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272620012701 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272620012702 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 272620012703 putative N-terminal domain interface [polypeptide binding]; other site 272620012704 putative dimer interface [polypeptide binding]; other site 272620012705 putative substrate binding pocket (H-site) [chemical binding]; other site 272620012706 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 272620012707 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 272620012708 putative active site [active] 272620012709 metal binding site [ion binding]; metal-binding site 272620012710 trehalase; Provisional; Region: treF; PRK13270 272620012711 Trehalase; Region: Trehalase; pfam01204 272620012712 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 272620012713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272620012714 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 272620012715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620012716 NAD(P) binding site [chemical binding]; other site 272620012717 active site 272620012718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620012719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620012720 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 272620012721 putative effector binding pocket; other site 272620012722 putative dimerization interface [polypeptide binding]; other site 272620012723 inner membrane protein YhjD; Region: TIGR00766 272620012724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012725 metabolite-proton symporter; Region: 2A0106; TIGR00883 272620012726 putative substrate translocation pore; other site 272620012727 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 272620012728 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272620012729 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620012730 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272620012731 substrate binding site [chemical binding]; other site 272620012732 ATP binding site [chemical binding]; other site 272620012733 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 272620012734 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 272620012735 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 272620012736 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272620012737 putative diguanylate cyclase; Provisional; Region: PRK13561 272620012738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 272620012739 dimerization interface [polypeptide binding]; other site 272620012740 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620012741 metal binding site [ion binding]; metal-binding site 272620012742 active site 272620012743 I-site; other site 272620012744 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620012745 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 272620012746 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620012747 TPR motif; other site 272620012748 binding surface 272620012749 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620012750 binding surface 272620012751 TPR motif; other site 272620012752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620012753 binding surface 272620012754 TPR motif; other site 272620012755 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 272620012756 endo-1,4-D-glucanase; Provisional; Region: PRK11097 272620012757 cellulose synthase regulator protein; Provisional; Region: PRK11114 272620012758 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 272620012759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272620012760 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272620012761 DXD motif; other site 272620012762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272620012763 PilZ domain; Region: PilZ; pfam07238 272620012764 cell division protein; Provisional; Region: PRK10037 272620012765 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272620012766 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 272620012767 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 272620012768 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 272620012769 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 272620012770 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 272620012771 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 272620012772 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 272620012773 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 272620012774 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 272620012775 TPR motif; other site 272620012776 binding surface 272620012777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 272620012778 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 272620012779 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 272620012780 cellulose synthase regulator protein; Provisional; Region: PRK11114 272620012781 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272620012782 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 272620012783 DXD motif; other site 272620012784 PilZ domain; Region: PilZ; pfam07238 272620012785 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 272620012786 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620012787 P-loop; other site 272620012788 Magnesium ion binding site [ion binding]; other site 272620012789 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 272620012790 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620012791 Walker A/P-loop; other site 272620012792 ATP binding site [chemical binding]; other site 272620012793 Q-loop/lid; other site 272620012794 ABC transporter signature motif; other site 272620012795 Walker B; other site 272620012796 D-loop; other site 272620012797 H-loop/switch region; other site 272620012798 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272620012799 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 272620012800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620012801 Walker A/P-loop; other site 272620012802 ATP binding site [chemical binding]; other site 272620012803 Q-loop/lid; other site 272620012804 ABC transporter signature motif; other site 272620012805 Walker B; other site 272620012806 D-loop; other site 272620012807 H-loop/switch region; other site 272620012808 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 272620012809 dipeptide transporter; Provisional; Region: PRK10913 272620012810 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272620012811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620012812 dimer interface [polypeptide binding]; other site 272620012813 conserved gate region; other site 272620012814 putative PBP binding loops; other site 272620012815 ABC-ATPase subunit interface; other site 272620012816 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272620012817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620012818 dimer interface [polypeptide binding]; other site 272620012819 conserved gate region; other site 272620012820 putative PBP binding loops; other site 272620012821 ABC-ATPase subunit interface; other site 272620012822 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 272620012823 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 272620012824 peptide binding site [polypeptide binding]; other site 272620012825 putative transposase OrfB; Reviewed; Region: PHA02517 272620012826 HTH-like domain; Region: HTH_21; pfam13276 272620012827 Integrase core domain; Region: rve; pfam00665 272620012828 Integrase core domain; Region: rve_2; pfam13333 272620012829 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620012830 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620012831 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620012832 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272620012833 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272620012834 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272620012835 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 272620012836 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 272620012837 phosphoethanolamine transferase; Provisional; Region: PRK11560 272620012838 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 272620012839 Sulfatase; Region: Sulfatase; pfam00884 272620012840 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 272620012841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012842 putative substrate translocation pore; other site 272620012843 Autotransporter beta-domain; Region: Autotransporter; cl17461 272620012844 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 272620012845 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620012846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620012847 Coenzyme A binding pocket [chemical binding]; other site 272620012848 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 272620012849 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 272620012850 molybdopterin cofactor binding site [chemical binding]; other site 272620012851 substrate binding site [chemical binding]; other site 272620012852 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 272620012853 molybdopterin cofactor binding site; other site 272620012854 putative outer membrane lipoprotein; Provisional; Region: PRK10510 272620012855 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 272620012856 ligand binding site [chemical binding]; other site 272620012857 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620012858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620012859 DNA binding site [nucleotide binding] 272620012860 domain linker motif; other site 272620012861 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 272620012862 putative dimerization interface [polypeptide binding]; other site 272620012863 putative ligand binding site [chemical binding]; other site 272620012864 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272620012865 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620012866 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272620012867 substrate binding site [chemical binding]; other site 272620012868 ATP binding site [chemical binding]; other site 272620012869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012870 D-galactonate transporter; Region: 2A0114; TIGR00893 272620012871 putative substrate translocation pore; other site 272620012872 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 272620012873 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 272620012874 dimerization interface [polypeptide binding]; other site 272620012875 ligand binding site [chemical binding]; other site 272620012876 NADP binding site [chemical binding]; other site 272620012877 catalytic site [active] 272620012878 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 272620012879 benzoate transport; Region: 2A0115; TIGR00895 272620012880 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012881 putative substrate translocation pore; other site 272620012882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620012883 Predicted transcriptional regulator [Transcription]; Region: COG2944 272620012884 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620012885 salt bridge; other site 272620012886 non-specific DNA binding site [nucleotide binding]; other site 272620012887 sequence-specific DNA binding site [nucleotide binding]; other site 272620012888 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272620012889 DNA-binding site [nucleotide binding]; DNA binding site 272620012890 RNA-binding motif; other site 272620012891 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272620012892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620012893 Walker A/P-loop; other site 272620012894 ATP binding site [chemical binding]; other site 272620012895 Q-loop/lid; other site 272620012896 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620012897 ABC transporter signature motif; other site 272620012898 Walker B; other site 272620012899 D-loop; other site 272620012900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620012901 small toxic polypeptide; Provisional; Region: PRK09759 272620012902 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 272620012903 DALR anticodon binding domain; Region: DALR_1; pfam05746 272620012904 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 272620012905 dimer interface [polypeptide binding]; other site 272620012906 motif 1; other site 272620012907 active site 272620012908 motif 2; other site 272620012909 motif 3; other site 272620012910 YsaB-like lipoprotein; Region: YsaB; pfam13983 272620012911 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 272620012912 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272620012913 hypothetical protein; Provisional; Region: PRK11383 272620012914 yiaA/B two helix domain; Region: YiaAB; pfam05360 272620012915 yiaA/B two helix domain; Region: YiaAB; pfam05360 272620012916 hypothetical protein; Provisional; Region: PRK11403 272620012917 yiaA/B two helix domain; Region: YiaAB; cl01759 272620012918 xylulokinase; Provisional; Region: PRK15027 272620012919 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 272620012920 N- and C-terminal domain interface [polypeptide binding]; other site 272620012921 active site 272620012922 MgATP binding site [chemical binding]; other site 272620012923 catalytic site [active] 272620012924 metal binding site [ion binding]; metal-binding site 272620012925 xylulose binding site [chemical binding]; other site 272620012926 homodimer interface [polypeptide binding]; other site 272620012927 xylose isomerase; Provisional; Region: PRK05474 272620012928 xylose isomerase; Region: xylose_isom_A; TIGR02630 272620012929 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 272620012930 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 272620012931 putative ligand binding site [chemical binding]; other site 272620012932 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 272620012933 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620012934 Walker A/P-loop; other site 272620012935 ATP binding site [chemical binding]; other site 272620012936 Q-loop/lid; other site 272620012937 ABC transporter signature motif; other site 272620012938 Walker B; other site 272620012939 D-loop; other site 272620012940 H-loop/switch region; other site 272620012941 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620012942 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620012943 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620012944 TM-ABC transporter signature motif; other site 272620012945 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 272620012946 putative dimerization interface [polypeptide binding]; other site 272620012947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620012948 putative ligand binding site [chemical binding]; other site 272620012949 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620012950 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620012951 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620012952 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 272620012953 hypothetical protein; Provisional; Region: PRK10356 272620012954 alpha-amylase; Reviewed; Region: malS; PRK09505 272620012955 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272620012956 active site 272620012957 catalytic site [active] 272620012958 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 272620012959 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620012960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620012961 homodimer interface [polypeptide binding]; other site 272620012962 catalytic residue [active] 272620012963 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 272620012964 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 272620012965 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 272620012966 G1 box; other site 272620012967 putative GEF interaction site [polypeptide binding]; other site 272620012968 GTP/Mg2+ binding site [chemical binding]; other site 272620012969 Switch I region; other site 272620012970 G2 box; other site 272620012971 G3 box; other site 272620012972 Switch II region; other site 272620012973 G4 box; other site 272620012974 G5 box; other site 272620012975 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 272620012976 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 272620012977 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 272620012978 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 272620012979 selenocysteine synthase; Provisional; Region: PRK04311 272620012980 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 272620012981 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 272620012982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620012983 catalytic residue [active] 272620012984 putative glutathione S-transferase; Provisional; Region: PRK10357 272620012985 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 272620012986 putative C-terminal domain interface [polypeptide binding]; other site 272620012987 putative GSH binding site (G-site) [chemical binding]; other site 272620012988 putative dimer interface [polypeptide binding]; other site 272620012989 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 272620012990 dimer interface [polypeptide binding]; other site 272620012991 N-terminal domain interface [polypeptide binding]; other site 272620012992 putative substrate binding pocket (H-site) [chemical binding]; other site 272620012993 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 272620012994 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272620012995 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272620012996 active site 272620012997 P-loop; other site 272620012998 phosphorylation site [posttranslational modification] 272620012999 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620013000 active site 272620013001 phosphorylation site [posttranslational modification] 272620013002 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272620013003 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272620013004 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272620013005 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 272620013006 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 272620013007 Glycogen synthesis protein; Region: GlgS; cl11663 272620013008 hypothetical protein; Provisional; Region: PRK11020 272620013009 L-lactate permease; Provisional; Region: PRK10420 272620013010 glycolate transporter; Provisional; Region: PRK09695 272620013011 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 272620013012 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620013013 DNA-binding site [nucleotide binding]; DNA binding site 272620013014 FCD domain; Region: FCD; pfam07729 272620013015 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 272620013016 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 272620013017 active site 272620013018 substrate binding site [chemical binding]; other site 272620013019 FMN binding site [chemical binding]; other site 272620013020 putative catalytic residues [active] 272620013021 putative rRNA methylase; Provisional; Region: PRK10358 272620013022 serine acetyltransferase; Provisional; Region: cysE; PRK11132 272620013023 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 272620013024 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 272620013025 trimer interface [polypeptide binding]; other site 272620013026 active site 272620013027 substrate binding site [chemical binding]; other site 272620013028 CoA binding site [chemical binding]; other site 272620013029 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 272620013030 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272620013031 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272620013032 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 272620013033 SecA binding site; other site 272620013034 Preprotein binding site; other site 272620013035 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 272620013036 GSH binding site [chemical binding]; other site 272620013037 catalytic residues [active] 272620013038 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272620013039 active site residue [active] 272620013040 phosphoglyceromutase; Provisional; Region: PRK05434 272620013041 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 272620013042 Vps51/Vps67; Region: Vps51; pfam08700 272620013043 Peptidase family M23; Region: Peptidase_M23; pfam01551 272620013044 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 272620013045 NodB motif; other site 272620013046 putative active site [active] 272620013047 putative catalytic site [active] 272620013048 Zn binding site [ion binding]; other site 272620013049 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272620013050 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272620013051 putative metal binding site; other site 272620013052 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 272620013053 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272620013054 NAD(P) binding site [chemical binding]; other site 272620013055 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 272620013056 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 272620013057 substrate-cofactor binding pocket; other site 272620013058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620013059 catalytic residue [active] 272620013060 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 272620013061 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 272620013062 NADP binding site [chemical binding]; other site 272620013063 homopentamer interface [polypeptide binding]; other site 272620013064 substrate binding site [chemical binding]; other site 272620013065 active site 272620013066 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 272620013067 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 272620013068 putative active site [active] 272620013069 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 272620013070 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 272620013071 putative active site [active] 272620013072 O-Antigen ligase; Region: Wzy_C; pfam04932 272620013073 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 272620013074 putative active site [active] 272620013075 putative catalytic site [active] 272620013076 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 272620013077 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 272620013078 putative active site [active] 272620013079 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 272620013080 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272620013081 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 272620013082 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 272620013083 putative ADP-binding pocket [chemical binding]; other site 272620013084 putative glycosyl transferase; Provisional; Region: PRK10073 272620013085 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272620013086 active site 272620013087 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 272620013088 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 272620013089 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 272620013090 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272620013091 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 272620013092 putative metal binding site; other site 272620013093 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 272620013094 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 272620013095 active site 272620013096 (T/H)XGH motif; other site 272620013097 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272620013098 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272620013099 DNA binding site [nucleotide binding] 272620013100 catalytic residue [active] 272620013101 H2TH interface [polypeptide binding]; other site 272620013102 putative catalytic residues [active] 272620013103 turnover-facilitating residue; other site 272620013104 intercalation triad [nucleotide binding]; other site 272620013105 8OG recognition residue [nucleotide binding]; other site 272620013106 putative reading head residues; other site 272620013107 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272620013108 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272620013109 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 272620013110 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272620013111 hypothetical protein; Reviewed; Region: PRK00024 272620013112 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 272620013113 MPN+ (JAMM) motif; other site 272620013114 Zinc-binding site [ion binding]; other site 272620013115 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 272620013116 Flavoprotein; Region: Flavoprotein; pfam02441 272620013117 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 272620013118 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272620013119 trimer interface [polypeptide binding]; other site 272620013120 active site 272620013121 division inhibitor protein; Provisional; Region: slmA; PRK09480 272620013122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620013123 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 272620013124 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272620013125 active site 272620013126 ribonuclease PH; Reviewed; Region: rph; PRK00173 272620013127 Ribonuclease PH; Region: RNase_PH_bact; cd11362 272620013128 hexamer interface [polypeptide binding]; other site 272620013129 active site 272620013130 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272620013131 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272620013132 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272620013133 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272620013134 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272620013135 Walker A/P-loop; other site 272620013136 ATP binding site [chemical binding]; other site 272620013137 Q-loop/lid; other site 272620013138 ABC transporter signature motif; other site 272620013139 Walker B; other site 272620013140 D-loop; other site 272620013141 H-loop/switch region; other site 272620013142 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 272620013143 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620013144 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 272620013145 putative acyl-acceptor binding pocket; other site 272620013146 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 272620013147 hypothetical protein; Provisional; Region: PRK11820 272620013148 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 272620013149 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 272620013150 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 272620013151 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272620013152 tetramer interface [polypeptide binding]; other site 272620013153 active site 272620013154 Mg2+/Mn2+ binding site [ion binding]; other site 272620013155 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 272620013156 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 272620013157 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 272620013158 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272620013159 DNA binding site [nucleotide binding] 272620013160 active site 272620013161 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 272620013162 putative ion selectivity filter; other site 272620013163 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 272620013164 putative pore gating glutamate residue; other site 272620013165 Predicted membrane protein [Function unknown]; Region: COG2860 272620013166 UPF0126 domain; Region: UPF0126; pfam03458 272620013167 UPF0126 domain; Region: UPF0126; pfam03458 272620013168 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 272620013169 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 272620013170 nucleotide binding pocket [chemical binding]; other site 272620013171 K-X-D-G motif; other site 272620013172 catalytic site [active] 272620013173 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272620013174 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272620013175 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272620013176 catalytic site [active] 272620013177 G-X2-G-X-G-K; other site 272620013178 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 272620013179 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 272620013180 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620013181 Zn2+ binding site [ion binding]; other site 272620013182 Mg2+ binding site [ion binding]; other site 272620013183 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272620013184 synthetase active site [active] 272620013185 NTP binding site [chemical binding]; other site 272620013186 metal binding site [ion binding]; metal-binding site 272620013187 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272620013188 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272620013189 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 272620013190 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272620013191 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 272620013192 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 272620013193 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 272620013194 generic binding surface II; other site 272620013195 ssDNA binding site; other site 272620013196 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620013197 ATP binding site [chemical binding]; other site 272620013198 putative Mg++ binding site [ion binding]; other site 272620013199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620013200 nucleotide binding region [chemical binding]; other site 272620013201 ATP-binding site [chemical binding]; other site 272620013202 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 272620013203 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 272620013204 putative active site [active] 272620013205 ferredoxin-NADP reductase; Provisional; Region: PRK10926 272620013206 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 272620013207 FAD binding pocket [chemical binding]; other site 272620013208 FAD binding motif [chemical binding]; other site 272620013209 phosphate binding motif [ion binding]; other site 272620013210 beta-alpha-beta structure motif; other site 272620013211 NAD binding pocket [chemical binding]; other site 272620013212 Predicted membrane protein [Function unknown]; Region: COG3152 272620013213 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 272620013214 triosephosphate isomerase; Provisional; Region: PRK14567 272620013215 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272620013216 substrate binding site [chemical binding]; other site 272620013217 dimer interface [polypeptide binding]; other site 272620013218 catalytic triad [active] 272620013219 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 272620013220 transmembrane helices; other site 272620013221 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 272620013222 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 272620013223 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 272620013224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620013225 substrate binding pocket [chemical binding]; other site 272620013226 membrane-bound complex binding site; other site 272620013227 septal ring assembly protein ZapB; Provisional; Region: PRK15422 272620013228 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 272620013229 amphipathic channel; other site 272620013230 Asn-Pro-Ala signature motifs; other site 272620013231 glycerol kinase; Provisional; Region: glpK; PRK00047 272620013232 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272620013233 N- and C-terminal domain interface [polypeptide binding]; other site 272620013234 active site 272620013235 MgATP binding site [chemical binding]; other site 272620013236 catalytic site [active] 272620013237 metal binding site [ion binding]; metal-binding site 272620013238 glycerol binding site [chemical binding]; other site 272620013239 homotetramer interface [polypeptide binding]; other site 272620013240 homodimer interface [polypeptide binding]; other site 272620013241 FBP binding site [chemical binding]; other site 272620013242 protein IIAGlc interface [polypeptide binding]; other site 272620013243 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 272620013244 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 272620013245 AsmA family; Region: AsmA; pfam05170 272620013246 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272620013247 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620013248 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 272620013249 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620013250 active site turn [active] 272620013251 phosphorylation site [posttranslational modification] 272620013252 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 272620013253 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272620013254 NAD(P) binding site [chemical binding]; other site 272620013255 LDH/MDH dimer interface [polypeptide binding]; other site 272620013256 substrate binding site [chemical binding]; other site 272620013257 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620013258 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620013259 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620013260 putative active site [active] 272620013261 putative alpha-glucosidase; Provisional; Region: PRK10658 272620013262 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272620013263 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 272620013264 active site 272620013265 homotrimer interface [polypeptide binding]; other site 272620013266 catalytic site [active] 272620013267 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 272620013268 putative transporter; Provisional; Region: PRK11462 272620013269 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620013270 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 272620013271 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272620013272 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272620013273 putative NAD(P) binding site [chemical binding]; other site 272620013274 dimer interface [polypeptide binding]; other site 272620013275 Uncharacterized conserved protein [Function unknown]; Region: COG1359 272620013276 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 272620013277 Transcriptional regulator; Region: Rrf2; cl17282 272620013278 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 272620013279 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 272620013280 conserved cys residue [active] 272620013281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013283 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272620013284 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 272620013285 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 272620013286 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 272620013287 dimer interface [polypeptide binding]; other site 272620013288 ADP-ribose binding site [chemical binding]; other site 272620013289 active site 272620013290 nudix motif; other site 272620013291 metal binding site [ion binding]; metal-binding site 272620013292 EamA-like transporter family; Region: EamA; pfam00892 272620013293 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 272620013294 lipoprotein, YaeC family; Region: TIGR00363 272620013295 Cupin; Region: Cupin_6; pfam12852 272620013296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620013298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013299 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 272620013300 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 272620013301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 272620013302 SnoaL-like domain; Region: SnoaL_2; pfam12680 272620013303 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 272620013304 transcriptional regulator; Provisional; Region: PRK10632 272620013305 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620013306 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 272620013307 putative effector binding pocket; other site 272620013308 putative dimerization interface [polypeptide binding]; other site 272620013309 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 272620013310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013311 putative substrate translocation pore; other site 272620013312 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 272620013313 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620013314 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620013315 Coenzyme A binding pocket [chemical binding]; other site 272620013316 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 272620013317 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620013318 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620013319 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 272620013320 Protein export membrane protein; Region: SecD_SecF; cl14618 272620013321 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 272620013322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013323 putative substrate translocation pore; other site 272620013324 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 272620013325 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272620013326 putative active site [active] 272620013327 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 272620013328 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620013329 active site turn [active] 272620013330 phosphorylation site [posttranslational modification] 272620013331 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620013332 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272620013333 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272620013334 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 272620013335 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 272620013336 hypothetical protein; Provisional; Region: PRK09262 272620013337 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 272620013338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620013339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620013340 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 272620013341 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620013342 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 272620013343 putative dimerization interface [polypeptide binding]; other site 272620013344 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 272620013345 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 272620013346 putative active site [active] 272620013347 Fe(II) binding site [ion binding]; other site 272620013348 putative dimer interface [polypeptide binding]; other site 272620013349 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 272620013350 putative dimer interface [polypeptide binding]; other site 272620013351 putative N- and C-terminal domain interface [polypeptide binding]; other site 272620013352 benzoate transport; Region: 2A0115; TIGR00895 272620013353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013354 putative substrate translocation pore; other site 272620013355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620013356 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620013357 DNA binding site [nucleotide binding] 272620013358 domain linker motif; other site 272620013359 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 272620013360 ligand binding site [chemical binding]; other site 272620013361 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272620013362 active site 272620013363 P-loop; other site 272620013364 phosphorylation site [posttranslational modification] 272620013365 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272620013366 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272620013367 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272620013368 methionine cluster; other site 272620013369 active site 272620013370 phosphorylation site [posttranslational modification] 272620013371 metal binding site [ion binding]; metal-binding site 272620013372 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272620013373 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272620013374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620013375 dimer interface [polypeptide binding]; other site 272620013376 conserved gate region; other site 272620013377 putative PBP binding loops; other site 272620013378 ABC-ATPase subunit interface; other site 272620013379 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 272620013380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620013381 dimer interface [polypeptide binding]; other site 272620013382 conserved gate region; other site 272620013383 putative PBP binding loops; other site 272620013384 ABC-ATPase subunit interface; other site 272620013385 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 272620013386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620013387 Walker A/P-loop; other site 272620013388 ATP binding site [chemical binding]; other site 272620013389 Q-loop/lid; other site 272620013390 ABC transporter signature motif; other site 272620013391 Walker B; other site 272620013392 D-loop; other site 272620013393 H-loop/switch region; other site 272620013394 TOBE domain; Region: TOBE_2; pfam08402 272620013395 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 272620013396 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 272620013397 transcriptional regulator protein; Region: phnR; TIGR03337 272620013398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620013399 DNA-binding site [nucleotide binding]; DNA binding site 272620013400 UTRA domain; Region: UTRA; pfam07702 272620013401 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 272620013402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620013403 catalytic residue [active] 272620013404 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 272620013405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620013406 motif II; other site 272620013407 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 272620013408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013409 putative substrate translocation pore; other site 272620013410 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 272620013411 Predicted transcriptional regulator [Transcription]; Region: COG2944 272620013412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620013413 non-specific DNA binding site [nucleotide binding]; other site 272620013414 salt bridge; other site 272620013415 sequence-specific DNA binding site [nucleotide binding]; other site 272620013416 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 272620013417 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 272620013418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013419 putative substrate translocation pore; other site 272620013420 regulatory protein UhpC; Provisional; Region: PRK11663 272620013421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013422 putative substrate translocation pore; other site 272620013423 sensory histidine kinase UhpB; Provisional; Region: PRK11644 272620013424 MASE1; Region: MASE1; pfam05231 272620013425 Histidine kinase; Region: HisKA_3; pfam07730 272620013426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620013427 ATP binding site [chemical binding]; other site 272620013428 Mg2+ binding site [ion binding]; other site 272620013429 G-X-G motif; other site 272620013430 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 272620013431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620013432 active site 272620013433 phosphorylation site [posttranslational modification] 272620013434 intermolecular recognition site; other site 272620013435 dimerization interface [polypeptide binding]; other site 272620013436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620013437 DNA binding residues [nucleotide binding] 272620013438 dimerization interface [polypeptide binding]; other site 272620013439 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 272620013440 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 272620013441 putative valine binding site [chemical binding]; other site 272620013442 dimer interface [polypeptide binding]; other site 272620013443 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 272620013444 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620013445 PYR/PP interface [polypeptide binding]; other site 272620013446 dimer interface [polypeptide binding]; other site 272620013447 TPP binding site [chemical binding]; other site 272620013448 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620013449 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272620013450 TPP-binding site [chemical binding]; other site 272620013451 dimer interface [polypeptide binding]; other site 272620013452 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620013453 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620013454 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272620013455 Coenzyme A binding pocket [chemical binding]; other site 272620013456 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 272620013457 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 272620013458 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 272620013459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013460 putative substrate translocation pore; other site 272620013461 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 272620013462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620013463 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 272620013464 dimerization interface [polypeptide binding]; other site 272620013465 substrate binding pocket [chemical binding]; other site 272620013466 permease DsdX; Provisional; Region: PRK09921 272620013467 GntP family permease; Region: GntP_permease; pfam02447 272620013468 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 272620013469 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 272620013470 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620013471 catalytic residue [active] 272620013472 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 272620013473 Domain of unknown function (DUF202); Region: DUF202; pfam02656 272620013474 Predicted membrane protein [Function unknown]; Region: COG2149 272620013475 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272620013476 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 272620013477 NAD binding site [chemical binding]; other site 272620013478 sugar binding site [chemical binding]; other site 272620013479 divalent metal binding site [ion binding]; other site 272620013480 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620013481 dimer interface [polypeptide binding]; other site 272620013482 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 272620013483 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 272620013484 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620013485 active site turn [active] 272620013486 phosphorylation site [posttranslational modification] 272620013487 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272620013488 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620013489 DNA-binding site [nucleotide binding]; DNA binding site 272620013490 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 272620013491 putative transporter; Validated; Region: PRK03818 272620013492 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 272620013493 TrkA-C domain; Region: TrkA_C; pfam02080 272620013494 TrkA-C domain; Region: TrkA_C; pfam02080 272620013495 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 272620013496 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 272620013497 BRO family, N-terminal domain; Region: Bro-N; cl10591 272620013498 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272620013499 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272620013500 putative dimer interface [polypeptide binding]; other site 272620013501 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272620013502 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 272620013503 putative dimer interface [polypeptide binding]; other site 272620013504 hypothetical protein; Provisional; Region: PRK11616 272620013505 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 272620013506 FOG: WD40 repeat [General function prediction only]; Region: COG2319 272620013507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013508 D-galactonate transporter; Region: 2A0114; TIGR00893 272620013509 putative substrate translocation pore; other site 272620013510 galactonate dehydratase; Provisional; Region: PRK14017 272620013511 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 272620013512 putative active site pocket [active] 272620013513 putative metal binding site [ion binding]; other site 272620013514 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 272620013515 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272620013516 active site 272620013517 intersubunit interface [polypeptide binding]; other site 272620013518 catalytic residue [active] 272620013519 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 272620013520 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 272620013521 Transcriptional regulators [Transcription]; Region: FadR; COG2186 272620013522 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620013523 DNA-binding site [nucleotide binding]; DNA binding site 272620013524 FCD domain; Region: FCD; pfam07729 272620013525 Surface antigen; Region: Bac_surface_Ag; pfam01103 272620013526 sugar phosphate phosphatase; Provisional; Region: PRK10513 272620013527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620013528 active site 272620013529 motif I; other site 272620013530 motif II; other site 272620013531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620013532 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 272620013533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620013534 Mg2+ binding site [ion binding]; other site 272620013535 G-X-G motif; other site 272620013536 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272620013537 anchoring element; other site 272620013538 dimer interface [polypeptide binding]; other site 272620013539 ATP binding site [chemical binding]; other site 272620013540 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272620013541 active site 272620013542 putative metal-binding site [ion binding]; other site 272620013543 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272620013544 recF protein; Region: recf; TIGR00611 272620013545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620013546 Walker A/P-loop; other site 272620013547 ATP binding site [chemical binding]; other site 272620013548 Q-loop/lid; other site 272620013549 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620013550 ABC transporter signature motif; other site 272620013551 Walker B; other site 272620013552 D-loop; other site 272620013553 H-loop/switch region; other site 272620013554 DNA polymerase III subunit beta; Validated; Region: PRK05643 272620013555 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272620013556 putative DNA binding surface [nucleotide binding]; other site 272620013557 dimer interface [polypeptide binding]; other site 272620013558 beta-clamp/clamp loader binding surface; other site 272620013559 beta-clamp/translesion DNA polymerase binding surface; other site 272620013560 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 272620013561 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272620013562 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620013563 Walker A motif; other site 272620013564 ATP binding site [chemical binding]; other site 272620013565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272620013566 Walker B motif; other site 272620013567 arginine finger; other site 272620013568 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272620013569 DnaA box-binding interface [nucleotide binding]; other site 272620013570 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 272620013571 hypothetical protein; Validated; Region: PRK00041 272620013572 membrane protein insertase; Provisional; Region: PRK01318 272620013573 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 272620013574 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272620013575 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272620013576 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272620013577 G1 box; other site 272620013578 GTP/Mg2+ binding site [chemical binding]; other site 272620013579 Switch I region; other site 272620013580 G2 box; other site 272620013581 Switch II region; other site 272620013582 G3 box; other site 272620013583 G4 box; other site 272620013584 G5 box; other site 272620013585 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272620013586 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 272620013587 active site 272620013588 Int/Topo IB signature motif; other site 272620013589 DNA binding site [nucleotide binding] 272620013590 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 272620013591 Integrase; Region: Integrase_1; pfam12835 272620013592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 272620013593 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 272620013594 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272620013595 AAA domain; Region: AAA_25; pfam13481 272620013596 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272620013597 Walker B motif; other site 272620013598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620013599 Coenzyme A binding pocket [chemical binding]; other site 272620013600 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 272620013601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013602 putative substrate translocation pore; other site 272620013603 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 272620013604 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620013605 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 272620013606 substrate binding pocket [chemical binding]; other site 272620013607 dimerization interface [polypeptide binding]; other site 272620013608 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 272620013609 Predicted flavoprotein [General function prediction only]; Region: COG0431 272620013610 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272620013611 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272620013612 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 272620013613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620013614 motif II; other site 272620013615 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272620013616 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272620013617 active site 272620013618 trimer interface [polypeptide binding]; other site 272620013619 allosteric site; other site 272620013620 active site lid [active] 272620013621 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272620013622 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 272620013623 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 272620013624 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 272620013625 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 272620013626 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 272620013627 trimer interface; other site 272620013628 sugar binding site [chemical binding]; other site 272620013629 transcriptional regulator PhoU; Provisional; Region: PRK11115 272620013630 PhoU domain; Region: PhoU; pfam01895 272620013631 PhoU domain; Region: PhoU; pfam01895 272620013632 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 272620013633 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272620013634 Walker A/P-loop; other site 272620013635 ATP binding site [chemical binding]; other site 272620013636 Q-loop/lid; other site 272620013637 ABC transporter signature motif; other site 272620013638 Walker B; other site 272620013639 D-loop; other site 272620013640 H-loop/switch region; other site 272620013641 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 272620013642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620013643 dimer interface [polypeptide binding]; other site 272620013644 conserved gate region; other site 272620013645 putative PBP binding loops; other site 272620013646 ABC-ATPase subunit interface; other site 272620013647 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 272620013648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620013649 dimer interface [polypeptide binding]; other site 272620013650 conserved gate region; other site 272620013651 putative PBP binding loops; other site 272620013652 ABC-ATPase subunit interface; other site 272620013653 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620013654 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 272620013655 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 272620013656 glutaminase active site [active] 272620013657 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272620013658 dimer interface [polypeptide binding]; other site 272620013659 active site 272620013660 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272620013661 dimer interface [polypeptide binding]; other site 272620013662 active site 272620013663 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 272620013664 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 272620013665 Substrate binding site; other site 272620013666 Mg++ binding site; other site 272620013667 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 272620013668 active site 272620013669 substrate binding site [chemical binding]; other site 272620013670 CoA binding site [chemical binding]; other site 272620013671 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 272620013672 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272620013673 gamma subunit interface [polypeptide binding]; other site 272620013674 epsilon subunit interface [polypeptide binding]; other site 272620013675 LBP interface [polypeptide binding]; other site 272620013676 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272620013677 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272620013678 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272620013679 alpha subunit interaction interface [polypeptide binding]; other site 272620013680 Walker A motif; other site 272620013681 ATP binding site [chemical binding]; other site 272620013682 Walker B motif; other site 272620013683 inhibitor binding site; inhibition site 272620013684 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272620013685 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272620013686 core domain interface [polypeptide binding]; other site 272620013687 delta subunit interface [polypeptide binding]; other site 272620013688 epsilon subunit interface [polypeptide binding]; other site 272620013689 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272620013690 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272620013691 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272620013692 beta subunit interaction interface [polypeptide binding]; other site 272620013693 Walker A motif; other site 272620013694 ATP binding site [chemical binding]; other site 272620013695 Walker B motif; other site 272620013696 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272620013697 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 272620013698 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272620013699 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272620013700 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272620013701 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 272620013702 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272620013703 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272620013704 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 272620013705 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272620013706 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620013707 S-adenosylmethionine binding site [chemical binding]; other site 272620013708 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272620013709 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 272620013710 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272620013711 FMN-binding protein MioC; Provisional; Region: PRK09004 272620013712 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 272620013713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620013714 putative DNA binding site [nucleotide binding]; other site 272620013715 putative Zn2+ binding site [ion binding]; other site 272620013716 AsnC family; Region: AsnC_trans_reg; pfam01037 272620013717 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 272620013718 dimer interface [polypeptide binding]; other site 272620013719 active site 272620013720 hypothetical protein; Provisional; Region: yieM; PRK10997 272620013721 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 272620013722 metal ion-dependent adhesion site (MIDAS); other site 272620013723 regulatory ATPase RavA; Provisional; Region: PRK13531 272620013724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620013725 Walker A motif; other site 272620013726 ATP binding site [chemical binding]; other site 272620013727 Walker B motif; other site 272620013728 arginine finger; other site 272620013729 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 272620013730 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 272620013731 potassium uptake protein; Region: kup; TIGR00794 272620013732 D-ribose pyranase; Provisional; Region: PRK11797 272620013733 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 272620013734 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620013735 Walker A/P-loop; other site 272620013736 ATP binding site [chemical binding]; other site 272620013737 Q-loop/lid; other site 272620013738 ABC transporter signature motif; other site 272620013739 Walker B; other site 272620013740 D-loop; other site 272620013741 H-loop/switch region; other site 272620013742 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620013743 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620013744 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620013745 TM-ABC transporter signature motif; other site 272620013746 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 272620013747 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 272620013748 ligand binding site [chemical binding]; other site 272620013749 dimerization interface [polypeptide binding]; other site 272620013750 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620013751 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 272620013752 substrate binding site [chemical binding]; other site 272620013753 dimer interface [polypeptide binding]; other site 272620013754 ATP binding site [chemical binding]; other site 272620013755 transcriptional repressor RbsR; Provisional; Region: PRK10423 272620013756 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620013757 DNA binding site [nucleotide binding] 272620013758 domain linker motif; other site 272620013759 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 272620013760 dimerization interface [polypeptide binding]; other site 272620013761 ligand binding site [chemical binding]; other site 272620013762 putative transporter; Provisional; Region: PRK10504 272620013763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013764 putative substrate translocation pore; other site 272620013765 Transcriptional regulators [Transcription]; Region: GntR; COG1802 272620013766 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620013767 DNA-binding site [nucleotide binding]; DNA binding site 272620013768 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 272620013769 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 272620013770 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 272620013771 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 272620013772 GTP binding site; other site 272620013773 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 272620013774 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 272620013775 serine/threonine protein kinase; Provisional; Region: PRK11768 272620013776 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 272620013777 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 272620013778 catalytic residues [active] 272620013779 hinge region; other site 272620013780 alpha helical domain; other site 272620013781 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272620013782 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 272620013783 putative acyl-acceptor binding pocket; other site 272620013784 DNA polymerase I; Provisional; Region: PRK05755 272620013785 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272620013786 active site 272620013787 metal binding site 1 [ion binding]; metal-binding site 272620013788 putative 5' ssDNA interaction site; other site 272620013789 metal binding site 3; metal-binding site 272620013790 metal binding site 2 [ion binding]; metal-binding site 272620013791 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272620013792 putative DNA binding site [nucleotide binding]; other site 272620013793 putative metal binding site [ion binding]; other site 272620013794 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 272620013795 active site 272620013796 catalytic site [active] 272620013797 substrate binding site [chemical binding]; other site 272620013798 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272620013799 active site 272620013800 DNA binding site [nucleotide binding] 272620013801 catalytic site [active] 272620013802 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272620013803 G1 box; other site 272620013804 GTP/Mg2+ binding site [chemical binding]; other site 272620013805 Switch I region; other site 272620013806 G2 box; other site 272620013807 G3 box; other site 272620013808 Switch II region; other site 272620013809 G4 box; other site 272620013810 G5 box; other site 272620013811 Der GTPase activator; Provisional; Region: PRK05244 272620013812 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 272620013813 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620013814 FeS/SAM binding site; other site 272620013815 HemN C-terminal domain; Region: HemN_C; pfam06969 272620013816 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 272620013817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620013818 active site 272620013819 phosphorylation site [posttranslational modification] 272620013820 intermolecular recognition site; other site 272620013821 dimerization interface [polypeptide binding]; other site 272620013822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620013823 Walker A motif; other site 272620013824 ATP binding site [chemical binding]; other site 272620013825 Walker B motif; other site 272620013826 arginine finger; other site 272620013827 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620013828 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 272620013829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 272620013830 putative active site [active] 272620013831 heme pocket [chemical binding]; other site 272620013832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620013833 dimer interface [polypeptide binding]; other site 272620013834 phosphorylation site [posttranslational modification] 272620013835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620013836 ATP binding site [chemical binding]; other site 272620013837 Mg2+ binding site [ion binding]; other site 272620013838 G-X-G motif; other site 272620013839 glutamine synthetase; Provisional; Region: glnA; PRK09469 272620013840 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 272620013841 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 272620013842 GTP-binding protein; Provisional; Region: PRK10218 272620013843 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272620013844 G1 box; other site 272620013845 putative GEF interaction site [polypeptide binding]; other site 272620013846 GTP/Mg2+ binding site [chemical binding]; other site 272620013847 Switch I region; other site 272620013848 G2 box; other site 272620013849 G3 box; other site 272620013850 Switch II region; other site 272620013851 G4 box; other site 272620013852 G5 box; other site 272620013853 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272620013854 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272620013855 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 272620013856 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620013857 motif II; other site 272620013858 hypothetical protein; Reviewed; Region: PRK01637 272620013859 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 272620013860 putative active site [active] 272620013861 dimerization interface [polypeptide binding]; other site 272620013862 putative tRNAtyr binding site [nucleotide binding]; other site 272620013863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620013864 Coenzyme A binding pocket [chemical binding]; other site 272620013865 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 272620013866 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272620013867 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 272620013868 substrate binding pocket [chemical binding]; other site 272620013869 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 272620013870 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272620013871 oligomeric interface; other site 272620013872 putative active site [active] 272620013873 homodimer interface [polypeptide binding]; other site 272620013874 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 272620013875 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 272620013876 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 272620013877 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 272620013878 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 272620013879 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 272620013880 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620013881 molybdopterin cofactor binding site; other site 272620013882 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 272620013883 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 272620013884 molybdopterin cofactor binding site; other site 272620013885 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 272620013886 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 272620013887 dimerization interface [polypeptide binding]; other site 272620013888 allosteric effector site; other site 272620013889 active site 272620013890 ADP/pyrophosphate binding site [chemical binding]; other site 272620013891 fructose-1,6-bisphosphate binding site; other site 272620013892 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272620013893 active site 272620013894 P-loop; other site 272620013895 phosphorylation site [posttranslational modification] 272620013896 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 272620013897 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272620013898 intersubunit interface [polypeptide binding]; other site 272620013899 active site 272620013900 zinc binding site [ion binding]; other site 272620013901 Na+ binding site [ion binding]; other site 272620013902 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620013903 active site 272620013904 phosphorylation site [posttranslational modification] 272620013905 AAA domain; Region: AAA_18; pfam13238 272620013906 AAA domain; Region: AAA_17; pfam13207 272620013907 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 272620013908 AzlC protein; Region: AzlC; cl00570 272620013909 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620013910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620013911 non-specific DNA binding site [nucleotide binding]; other site 272620013912 salt bridge; other site 272620013913 sequence-specific DNA binding site [nucleotide binding]; other site 272620013914 Cupin domain; Region: Cupin_2; cl17218 272620013915 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620013916 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620013917 DNA binding site [nucleotide binding] 272620013918 domain linker motif; other site 272620013919 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 272620013920 ligand binding site [chemical binding]; other site 272620013921 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 272620013922 Melibiase; Region: Melibiase; pfam02065 272620013923 galactoside permease; Reviewed; Region: lacY; PRK09528 272620013924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620013925 putative substrate translocation pore; other site 272620013926 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 272620013927 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 272620013928 lactaldehyde reductase; Region: lactal_redase; TIGR02638 272620013929 dimer interface [polypeptide binding]; other site 272620013930 active site 272620013931 metal binding site [ion binding]; metal-binding site 272620013932 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620013933 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620013934 TM-ABC transporter signature motif; other site 272620013935 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620013936 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620013937 TM-ABC transporter signature motif; other site 272620013938 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620013939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620013940 Walker A/P-loop; other site 272620013941 ATP binding site [chemical binding]; other site 272620013942 Q-loop/lid; other site 272620013943 ABC transporter signature motif; other site 272620013944 Walker B; other site 272620013945 D-loop; other site 272620013946 H-loop/switch region; other site 272620013947 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620013948 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272620013949 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 272620013950 ligand binding site [chemical binding]; other site 272620013951 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 272620013952 intersubunit interface [polypeptide binding]; other site 272620013953 active site 272620013954 Zn2+ binding site [ion binding]; other site 272620013955 L-rhamnose isomerase; Provisional; Region: PRK01076 272620013956 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 272620013957 N- and C-terminal domain interface [polypeptide binding]; other site 272620013958 active site 272620013959 putative catalytic site [active] 272620013960 metal binding site [ion binding]; metal-binding site 272620013961 ATP binding site [chemical binding]; other site 272620013962 rhamnulokinase; Provisional; Region: rhaB; PRK10640 272620013963 carbohydrate binding site [chemical binding]; other site 272620013964 transcriptional activator RhaS; Provisional; Region: PRK13503 272620013965 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620013966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013968 transcriptional activator RhaR; Provisional; Region: PRK13502 272620013969 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620013970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620013971 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 272620013972 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 272620013973 superoxide dismutase; Provisional; Region: PRK10925 272620013974 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 272620013975 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 272620013976 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 272620013977 MOSC domain; Region: MOSC; pfam03473 272620013978 3-alpha domain; Region: 3-alpha; pfam03475 272620013979 two-component sensor protein; Provisional; Region: cpxA; PRK09470 272620013980 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620013981 dimerization interface [polypeptide binding]; other site 272620013982 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620013983 dimer interface [polypeptide binding]; other site 272620013984 phosphorylation site [posttranslational modification] 272620013985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620013986 ATP binding site [chemical binding]; other site 272620013987 Mg2+ binding site [ion binding]; other site 272620013988 G-X-G motif; other site 272620013989 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 272620013990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620013991 active site 272620013992 phosphorylation site [posttranslational modification] 272620013993 intermolecular recognition site; other site 272620013994 dimerization interface [polypeptide binding]; other site 272620013995 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620013996 DNA binding site [nucleotide binding] 272620013997 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 272620013998 dimer interface [polypeptide binding]; other site 272620013999 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 272620014000 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272620014001 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 272620014002 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 272620014003 active site 272620014004 ADP/pyrophosphate binding site [chemical binding]; other site 272620014005 dimerization interface [polypeptide binding]; other site 272620014006 allosteric effector site; other site 272620014007 fructose-1,6-bisphosphate binding site; other site 272620014008 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 272620014009 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 272620014010 UbiA prenyltransferase family; Region: UbiA; pfam01040 272620014011 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 272620014012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620014013 Walker A motif; other site 272620014014 ATP binding site [chemical binding]; other site 272620014015 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 272620014016 Walker B motif; other site 272620014017 arginine finger; other site 272620014018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 272620014019 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 272620014020 active site 272620014021 HslU subunit interaction site [polypeptide binding]; other site 272620014022 essential cell division protein FtsN; Provisional; Region: PRK10927 272620014023 cell division protein FtsN; Provisional; Region: PRK12757 272620014024 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620014025 DNA binding site [nucleotide binding] 272620014026 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 272620014027 domain linker motif; other site 272620014028 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 272620014029 dimerization interface [polypeptide binding]; other site 272620014030 ligand binding site [chemical binding]; other site 272620014031 primosome assembly protein PriA; Validated; Region: PRK05580 272620014032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620014033 ATP binding site [chemical binding]; other site 272620014034 putative Mg++ binding site [ion binding]; other site 272620014035 helicase superfamily c-terminal domain; Region: HELICc; smart00490 272620014036 ATP-binding site [chemical binding]; other site 272620014037 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272620014038 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 272620014039 dimerization interface [polypeptide binding]; other site 272620014040 DNA binding site [nucleotide binding] 272620014041 corepressor binding sites; other site 272620014042 cystathionine gamma-synthase; Provisional; Region: PRK08045 272620014043 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 272620014044 homodimer interface [polypeptide binding]; other site 272620014045 substrate-cofactor binding pocket; other site 272620014046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620014047 catalytic residue [active] 272620014048 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 272620014049 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 272620014050 putative catalytic residues [active] 272620014051 putative nucleotide binding site [chemical binding]; other site 272620014052 putative aspartate binding site [chemical binding]; other site 272620014053 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 272620014054 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 272620014055 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 272620014056 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 272620014057 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 272620014058 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 272620014059 active site 272620014060 metal binding site [ion binding]; metal-binding site 272620014061 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272620014062 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 272620014063 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 272620014064 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014065 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 272620014066 dimerization interface [polypeptide binding]; other site 272620014067 substrate binding pocket [chemical binding]; other site 272620014068 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 272620014069 FAD binding site [chemical binding]; other site 272620014070 EamA-like transporter family; Region: EamA; pfam00892 272620014071 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272620014072 EamA-like transporter family; Region: EamA; pfam00892 272620014073 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 272620014074 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 272620014075 dimer interface [polypeptide binding]; other site 272620014076 active site 272620014077 metal binding site [ion binding]; metal-binding site 272620014078 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 272620014079 active site 272620014080 intersubunit interactions; other site 272620014081 catalytic residue [active] 272620014082 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620014083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620014084 zinc/cadmium-binding protein; Provisional; Region: PRK10306 272620014085 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 272620014086 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 272620014087 acetylornithine deacetylase; Provisional; Region: PRK05111 272620014088 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 272620014089 metal binding site [ion binding]; metal-binding site 272620014090 putative dimer interface [polypeptide binding]; other site 272620014091 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 272620014092 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 272620014093 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 272620014094 nucleotide binding site [chemical binding]; other site 272620014095 N-acetyl-L-glutamate binding site [chemical binding]; other site 272620014096 argininosuccinate lyase; Provisional; Region: PRK04833 272620014097 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 272620014098 active sites [active] 272620014099 tetramer interface [polypeptide binding]; other site 272620014100 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 272620014101 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014102 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 272620014103 dimerization interface [polypeptide binding]; other site 272620014104 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 272620014105 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620014106 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272620014107 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 272620014108 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620014109 hypothetical protein; Provisional; Region: PRK11056 272620014110 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 272620014111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620014112 S-adenosylmethionine binding site [chemical binding]; other site 272620014113 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 272620014114 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620014115 N-terminal plug; other site 272620014116 ligand-binding site [chemical binding]; other site 272620014117 glutamate racemase; Provisional; Region: PRK00865 272620014118 transcriptional regulator HdfR; Provisional; Region: PRK03601 272620014119 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014120 LysR substrate binding domain; Region: LysR_substrate; pfam03466 272620014121 hypothetical protein; Provisional; Region: PRK11027 272620014122 putative ATP-dependent protease; Provisional; Region: PRK09862 272620014123 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272620014124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620014125 Walker A motif; other site 272620014126 ATP binding site [chemical binding]; other site 272620014127 Walker B motif; other site 272620014128 arginine finger; other site 272620014129 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 272620014130 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 272620014131 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620014132 PYR/PP interface [polypeptide binding]; other site 272620014133 dimer interface [polypeptide binding]; other site 272620014134 TPP binding site [chemical binding]; other site 272620014135 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620014136 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 272620014137 TPP-binding site [chemical binding]; other site 272620014138 dimer interface [polypeptide binding]; other site 272620014139 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 272620014140 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 272620014141 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 272620014142 homodimer interface [polypeptide binding]; other site 272620014143 substrate-cofactor binding pocket; other site 272620014144 catalytic residue [active] 272620014145 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 272620014146 threonine dehydratase; Reviewed; Region: PRK09224 272620014147 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272620014148 tetramer interface [polypeptide binding]; other site 272620014149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620014150 catalytic residue [active] 272620014151 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 272620014152 putative Ile/Val binding site [chemical binding]; other site 272620014153 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 272620014154 putative Ile/Val binding site [chemical binding]; other site 272620014155 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014156 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 272620014157 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 272620014158 putative dimerization interface [polypeptide binding]; other site 272620014159 ketol-acid reductoisomerase; Validated; Region: PRK05225 272620014160 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 272620014161 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272620014162 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 272620014163 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 272620014164 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272620014165 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 272620014166 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 272620014167 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 272620014168 Part of AAA domain; Region: AAA_19; pfam13245 272620014169 Family description; Region: UvrD_C_2; pfam13538 272620014170 Protein of unknown function (DUF554); Region: DUF554; pfam04474 272620014171 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272620014172 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620014173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014174 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 272620014175 substrate binding pocket [chemical binding]; other site 272620014176 dimerization interface [polypeptide binding]; other site 272620014177 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 272620014178 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 272620014179 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 272620014180 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272620014181 ATP binding site [chemical binding]; other site 272620014182 Mg++ binding site [ion binding]; other site 272620014183 motif III; other site 272620014184 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620014185 nucleotide binding region [chemical binding]; other site 272620014186 ATP-binding site [chemical binding]; other site 272620014187 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272620014188 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 272620014189 catalytic residues [active] 272620014190 transcription termination factor Rho; Provisional; Region: rho; PRK09376 272620014191 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 272620014192 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 272620014193 RNA binding site [nucleotide binding]; other site 272620014194 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 272620014195 multimer interface [polypeptide binding]; other site 272620014196 Walker A motif; other site 272620014197 ATP binding site [chemical binding]; other site 272620014198 Walker B motif; other site 272620014199 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 272620014200 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 272620014201 Mg++ binding site [ion binding]; other site 272620014202 putative catalytic motif [active] 272620014203 substrate binding site [chemical binding]; other site 272620014204 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 272620014205 Chain length determinant protein; Region: Wzz; pfam02706 272620014206 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 272620014207 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 272620014208 homodimer interface [polypeptide binding]; other site 272620014209 active site 272620014210 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 272620014211 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 272620014212 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 272620014213 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 272620014214 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 272620014215 NAD binding site [chemical binding]; other site 272620014216 substrate binding site [chemical binding]; other site 272620014217 homodimer interface [polypeptide binding]; other site 272620014218 active site 272620014219 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 272620014220 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 272620014221 substrate binding site; other site 272620014222 tetramer interface; other site 272620014223 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 272620014224 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 272620014225 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 272620014226 inhibitor-cofactor binding pocket; inhibition site 272620014227 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620014228 catalytic residue [active] 272620014229 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 272620014230 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 272620014231 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 272620014232 putative common antigen polymerase; Provisional; Region: PRK02975 272620014233 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 272620014234 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 272620014235 putative transport protein YifK; Provisional; Region: PRK10746 272620014236 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 272620014237 HemY protein N-terminus; Region: HemY_N; pfam07219 272620014238 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 272620014239 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 272620014240 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 272620014241 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 272620014242 active site 272620014243 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 272620014244 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 272620014245 domain interfaces; other site 272620014246 active site 272620014247 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 272620014248 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 272620014249 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 272620014250 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 272620014251 putative iron binding site [ion binding]; other site 272620014252 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 272620014253 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 272620014254 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272620014255 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 272620014256 hypothetical protein; Provisional; Region: PRK10963 272620014257 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 272620014258 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 272620014259 active site 272620014260 Int/Topo IB signature motif; other site 272620014261 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 272620014262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620014263 motif II; other site 272620014264 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 272620014265 Part of AAA domain; Region: AAA_19; pfam13245 272620014266 Family description; Region: UvrD_C_2; pfam13538 272620014267 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 272620014268 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 272620014269 Cl binding site [ion binding]; other site 272620014270 oligomer interface [polypeptide binding]; other site 272620014271 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 272620014272 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 272620014273 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 272620014274 CoenzymeA binding site [chemical binding]; other site 272620014275 subunit interaction site [polypeptide binding]; other site 272620014276 PHB binding site; other site 272620014277 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 272620014278 dimerization interface [polypeptide binding]; other site 272620014279 substrate binding site [chemical binding]; other site 272620014280 active site 272620014281 calcium binding site [ion binding]; other site 272620014282 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 272620014283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620014284 ATP binding site [chemical binding]; other site 272620014285 putative Mg++ binding site [ion binding]; other site 272620014286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620014287 nucleotide binding region [chemical binding]; other site 272620014288 ATP-binding site [chemical binding]; other site 272620014289 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 272620014290 Helicase and RNase D C-terminal; Region: HRDC; smart00341 272620014291 threonine efflux system; Provisional; Region: PRK10229 272620014292 putative transposase; Provisional; Region: PRK09857 272620014293 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620014294 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 272620014295 lysophospholipase L2; Provisional; Region: PRK10749 272620014296 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272620014297 putative hydrolase; Provisional; Region: PRK10976 272620014298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620014299 active site 272620014300 motif I; other site 272620014301 motif II; other site 272620014302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620014303 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 272620014304 EamA-like transporter family; Region: EamA; pfam00892 272620014305 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 272620014306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014307 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 272620014308 putative dimerization interface [polypeptide binding]; other site 272620014309 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 272620014310 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 272620014311 THF binding site; other site 272620014312 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 272620014313 substrate binding site [chemical binding]; other site 272620014314 THF binding site; other site 272620014315 zinc-binding site [ion binding]; other site 272620014316 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 272620014317 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272620014318 uridine phosphorylase; Provisional; Region: PRK11178 272620014319 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 272620014320 DNA recombination protein RmuC; Provisional; Region: PRK10361 272620014321 RmuC family; Region: RmuC; pfam02646 272620014322 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 272620014323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620014324 S-adenosylmethionine binding site [chemical binding]; other site 272620014325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 272620014326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 272620014327 SCP-2 sterol transfer family; Region: SCP2; pfam02036 272620014328 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 272620014329 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 272620014330 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 272620014331 sec-independent translocase; Provisional; Region: PRK01770 272620014332 sec-independent translocase; Provisional; Region: tatB; PRK00404 272620014333 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 272620014334 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272620014335 active site 272620014336 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 272620014337 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 272620014338 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 272620014339 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 272620014340 FMN reductase; Validated; Region: fre; PRK08051 272620014341 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 272620014342 FAD binding pocket [chemical binding]; other site 272620014343 FAD binding motif [chemical binding]; other site 272620014344 phosphate binding motif [ion binding]; other site 272620014345 beta-alpha-beta structure motif; other site 272620014346 NAD binding pocket [chemical binding]; other site 272620014347 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 272620014348 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 272620014349 dimer interface [polypeptide binding]; other site 272620014350 active site 272620014351 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 272620014352 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 272620014353 substrate binding site [chemical binding]; other site 272620014354 oxyanion hole (OAH) forming residues; other site 272620014355 trimer interface [polypeptide binding]; other site 272620014356 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272620014357 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620014358 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 272620014359 proline dipeptidase; Provisional; Region: PRK13607 272620014360 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 272620014361 active site 272620014362 hypothetical protein; Provisional; Region: PRK11568 272620014363 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272620014364 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 272620014365 potassium transporter; Provisional; Region: PRK10750 272620014366 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 272620014367 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 272620014368 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 272620014369 FAD binding domain; Region: FAD_binding_4; pfam01565 272620014370 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 272620014371 Biotin operon repressor [Transcription]; Region: BirA; COG1654 272620014372 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 272620014373 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 272620014374 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 272620014375 pantothenate kinase; Provisional; Region: PRK05439 272620014376 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 272620014377 ATP-binding site [chemical binding]; other site 272620014378 CoA-binding site [chemical binding]; other site 272620014379 Mg2+-binding site [ion binding]; other site 272620014380 elongation factor Tu; Reviewed; Region: PRK00049 272620014381 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272620014382 G1 box; other site 272620014383 GEF interaction site [polypeptide binding]; other site 272620014384 GTP/Mg2+ binding site [chemical binding]; other site 272620014385 Switch I region; other site 272620014386 G2 box; other site 272620014387 G3 box; other site 272620014388 Switch II region; other site 272620014389 G4 box; other site 272620014390 G5 box; other site 272620014391 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272620014392 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272620014393 Antibiotic Binding Site [chemical binding]; other site 272620014394 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 272620014395 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272620014396 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272620014397 putative homodimer interface [polypeptide binding]; other site 272620014398 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272620014399 heterodimer interface [polypeptide binding]; other site 272620014400 homodimer interface [polypeptide binding]; other site 272620014401 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272620014402 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272620014403 23S rRNA interface [nucleotide binding]; other site 272620014404 L7/L12 interface [polypeptide binding]; other site 272620014405 putative thiostrepton binding site; other site 272620014406 L25 interface [polypeptide binding]; other site 272620014407 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272620014408 mRNA/rRNA interface [nucleotide binding]; other site 272620014409 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272620014410 23S rRNA interface [nucleotide binding]; other site 272620014411 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272620014412 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272620014413 core dimer interface [polypeptide binding]; other site 272620014414 peripheral dimer interface [polypeptide binding]; other site 272620014415 L10 interface [polypeptide binding]; other site 272620014416 L11 interface [polypeptide binding]; other site 272620014417 putative EF-Tu interaction site [polypeptide binding]; other site 272620014418 putative EF-G interaction site [polypeptide binding]; other site 272620014419 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272620014420 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272620014421 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 272620014422 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272620014423 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 272620014424 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272620014425 RPB3 interaction site [polypeptide binding]; other site 272620014426 RPB1 interaction site [polypeptide binding]; other site 272620014427 RPB11 interaction site [polypeptide binding]; other site 272620014428 RPB10 interaction site [polypeptide binding]; other site 272620014429 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272620014430 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 272620014431 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272620014432 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272620014433 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272620014434 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 272620014435 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272620014436 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 272620014437 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 272620014438 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272620014439 DNA binding site [nucleotide binding] 272620014440 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272620014441 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 272620014442 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 272620014443 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 272620014444 methionine cluster; other site 272620014445 active site 272620014446 phosphorylation site [posttranslational modification] 272620014447 metal binding site [ion binding]; metal-binding site 272620014448 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272620014449 active site 272620014450 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620014451 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620014452 metal binding site [ion binding]; metal-binding site 272620014453 active site 272620014454 I-site; other site 272620014455 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 272620014456 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620014457 FeS/SAM binding site; other site 272620014458 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 272620014459 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 272620014460 ThiS interaction site; other site 272620014461 putative active site [active] 272620014462 tetramer interface [polypeptide binding]; other site 272620014463 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 272620014464 thiS-thiF/thiG interaction site; other site 272620014465 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 272620014466 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 272620014467 ATP binding site [chemical binding]; other site 272620014468 substrate interface [chemical binding]; other site 272620014469 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 272620014470 thiamine phosphate binding site [chemical binding]; other site 272620014471 active site 272620014472 pyrophosphate binding site [ion binding]; other site 272620014473 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 272620014474 ThiC-associated domain; Region: ThiC-associated; pfam13667 272620014475 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 272620014476 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 272620014477 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 272620014478 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 272620014479 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 272620014480 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 272620014481 putative NADH binding site [chemical binding]; other site 272620014482 putative active site [active] 272620014483 nudix motif; other site 272620014484 putative metal binding site [ion binding]; other site 272620014485 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 272620014486 substrate binding site [chemical binding]; other site 272620014487 active site 272620014488 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 272620014489 Active_site [active] 272620014490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 272620014491 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 272620014492 IHF dimer interface [polypeptide binding]; other site 272620014493 IHF - DNA interface [nucleotide binding]; other site 272620014494 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 272620014495 zinc resistance protein; Provisional; Region: zraP; PRK11546 272620014496 dimer interface [polypeptide binding]; other site 272620014497 sensor protein ZraS; Provisional; Region: PRK10364 272620014498 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620014499 dimer interface [polypeptide binding]; other site 272620014500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620014501 ATP binding site [chemical binding]; other site 272620014502 Mg2+ binding site [ion binding]; other site 272620014503 G-X-G motif; other site 272620014504 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 272620014505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620014506 active site 272620014507 phosphorylation site [posttranslational modification] 272620014508 intermolecular recognition site; other site 272620014509 dimerization interface [polypeptide binding]; other site 272620014510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620014511 Walker A motif; other site 272620014512 ATP binding site [chemical binding]; other site 272620014513 Walker B motif; other site 272620014514 arginine finger; other site 272620014515 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 272620014516 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 272620014517 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 272620014518 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 272620014519 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 272620014520 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 272620014521 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 272620014522 purine monophosphate binding site [chemical binding]; other site 272620014523 dimer interface [polypeptide binding]; other site 272620014524 putative catalytic residues [active] 272620014525 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 272620014526 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 272620014527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620014528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620014529 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272620014530 Coenzyme A binding pocket [chemical binding]; other site 272620014531 homoserine O-succinyltransferase; Provisional; Region: PRK05368 272620014532 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 272620014533 proposed active site lysine [active] 272620014534 conserved cys residue [active] 272620014535 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 272620014536 malate synthase A; Region: malate_syn_A; TIGR01344 272620014537 active site 272620014538 isocitrate lyase; Provisional; Region: PRK15063 272620014539 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 272620014540 tetramer interface [polypeptide binding]; other site 272620014541 active site 272620014542 Mg2+/Mn2+ binding site [ion binding]; other site 272620014543 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 272620014544 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 272620014545 transcriptional repressor IclR; Provisional; Region: PRK11569 272620014546 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 272620014547 Bacterial transcriptional regulator; Region: IclR; pfam01614 272620014548 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 272620014549 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 272620014550 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 272620014551 substrate binding pocket [chemical binding]; other site 272620014552 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 272620014553 B12 binding site [chemical binding]; other site 272620014554 cobalt ligand [ion binding]; other site 272620014555 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 272620014556 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 272620014557 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 272620014558 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 272620014559 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 272620014560 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 272620014561 shikimate binding site; other site 272620014562 NAD(P) binding site [chemical binding]; other site 272620014563 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 272620014564 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272620014565 putative NAD(P) binding site [chemical binding]; other site 272620014566 catalytic Zn binding site [ion binding]; other site 272620014567 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 272620014568 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 272620014569 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272620014570 active site 272620014571 phosphorylation site [posttranslational modification] 272620014572 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620014573 active pocket/dimerization site; other site 272620014574 active site 272620014575 phosphorylation site [posttranslational modification] 272620014576 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 272620014577 classical (c) SDRs; Region: SDR_c; cd05233 272620014578 NAD(P) binding site [chemical binding]; other site 272620014579 active site 272620014580 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 272620014581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620014582 putative DNA binding site [nucleotide binding]; other site 272620014583 putative Zn2+ binding site [ion binding]; other site 272620014584 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 272620014585 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 272620014586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272620014587 RNA binding surface [nucleotide binding]; other site 272620014588 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 272620014589 probable active site [active] 272620014590 hypothetical protein; Provisional; Region: PRK10515 272620014591 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 272620014592 Sodium Bile acid symporter family; Region: SBF; pfam01758 272620014593 aspartate kinase III; Validated; Region: PRK09084 272620014594 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272620014595 nucleotide binding site [chemical binding]; other site 272620014596 substrate binding site [chemical binding]; other site 272620014597 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 272620014598 lysine allosteric regulatory site; other site 272620014599 dimer interface [polypeptide binding]; other site 272620014600 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 272620014601 dimer interface [polypeptide binding]; other site 272620014602 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 272620014603 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272620014604 active site 272620014605 dimer interface [polypeptide binding]; other site 272620014606 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272620014607 dimer interface [polypeptide binding]; other site 272620014608 active site 272620014609 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 272620014610 putative trimer interface [polypeptide binding]; other site 272620014611 putative active site [active] 272620014612 putative substrate binding site [chemical binding]; other site 272620014613 putative CoA binding site [chemical binding]; other site 272620014614 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620014615 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272620014616 homotrimer interaction site [polypeptide binding]; other site 272620014617 putative active site [active] 272620014618 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 272620014619 AzlC protein; Region: AzlC; pfam03591 272620014620 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 272620014621 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 272620014622 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272620014623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620014624 dimer interface [polypeptide binding]; other site 272620014625 conserved gate region; other site 272620014626 putative PBP binding loops; other site 272620014627 ABC-ATPase subunit interface; other site 272620014628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620014629 dimer interface [polypeptide binding]; other site 272620014630 conserved gate region; other site 272620014631 putative PBP binding loops; other site 272620014632 ABC-ATPase subunit interface; other site 272620014633 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 272620014634 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272620014635 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 272620014636 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272620014637 Walker A/P-loop; other site 272620014638 ATP binding site [chemical binding]; other site 272620014639 Q-loop/lid; other site 272620014640 ABC transporter signature motif; other site 272620014641 Walker B; other site 272620014642 D-loop; other site 272620014643 H-loop/switch region; other site 272620014644 TOBE domain; Region: TOBE_2; pfam08402 272620014645 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 272620014646 trimer interface; other site 272620014647 sugar binding site [chemical binding]; other site 272620014648 maltose regulon periplasmic protein; Provisional; Region: PRK10564 272620014649 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 272620014650 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 272620014651 UbiA prenyltransferase family; Region: UbiA; pfam01040 272620014652 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 272620014653 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 272620014654 putative acyl-acceptor binding pocket; other site 272620014655 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 272620014656 LexA repressor; Validated; Region: PRK00215 272620014657 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 272620014658 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272620014659 Catalytic site [active] 272620014660 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 272620014661 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 272620014662 hypothetical protein; Provisional; Region: PRK10428 272620014663 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 272620014664 metal binding site 2 [ion binding]; metal-binding site 272620014665 putative DNA binding helix; other site 272620014666 metal binding site 1 [ion binding]; metal-binding site 272620014667 dimer interface [polypeptide binding]; other site 272620014668 structural Zn2+ binding site [ion binding]; other site 272620014669 Cupin domain; Region: Cupin_2; cl17218 272620014670 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 272620014671 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272620014672 FMN binding site [chemical binding]; other site 272620014673 active site 272620014674 catalytic residues [active] 272620014675 substrate binding site [chemical binding]; other site 272620014676 phage shock protein G; Reviewed; Region: pspG; PRK09459 272620014677 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 272620014678 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 272620014679 NADP binding site [chemical binding]; other site 272620014680 dimer interface [polypeptide binding]; other site 272620014681 replicative DNA helicase; Provisional; Region: PRK08006 272620014682 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272620014683 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272620014684 Walker A motif; other site 272620014685 ATP binding site [chemical binding]; other site 272620014686 Walker B motif; other site 272620014687 DNA binding loops [nucleotide binding] 272620014688 alanine racemase; Reviewed; Region: alr; PRK00053 272620014689 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 272620014690 active site 272620014691 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272620014692 substrate binding site [chemical binding]; other site 272620014693 catalytic residues [active] 272620014694 dimer interface [polypeptide binding]; other site 272620014695 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 272620014696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620014697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620014698 homodimer interface [polypeptide binding]; other site 272620014699 catalytic residue [active] 272620014700 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620014701 active site 272620014702 motif I; other site 272620014703 motif II; other site 272620014704 Uncharacterized conserved protein [Function unknown]; Region: COG0432 272620014705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 272620014706 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272620014707 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272620014708 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272620014709 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272620014710 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272620014711 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272620014712 dimer interface [polypeptide binding]; other site 272620014713 ssDNA binding site [nucleotide binding]; other site 272620014714 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620014715 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 272620014716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620014717 substrate binding pocket [chemical binding]; other site 272620014718 membrane-bound complex binding site; other site 272620014719 hinge residues; other site 272620014720 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620014721 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620014722 catalytic residue [active] 272620014723 outer membrane receptor FepA; Provisional; Region: PRK13524 272620014724 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 272620014725 N-terminal plug; other site 272620014726 ligand-binding site [chemical binding]; other site 272620014727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620014728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620014729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620014730 Tannase and feruloyl esterase; Region: Tannase; pfam07519 272620014731 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 272620014732 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620014733 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620014734 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620014735 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620014736 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620014737 Surface antigen; Region: Bac_surface_Ag; pfam01103 272620014738 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272620014739 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 272620014740 active site 272620014741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272620014742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 272620014743 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 272620014744 putative dimerization interface [polypeptide binding]; other site 272620014745 putative ligand binding site [chemical binding]; other site 272620014746 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 272620014747 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272620014748 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620014749 Walker A/P-loop; other site 272620014750 ATP binding site [chemical binding]; other site 272620014751 Q-loop/lid; other site 272620014752 ABC transporter signature motif; other site 272620014753 Walker B; other site 272620014754 D-loop; other site 272620014755 H-loop/switch region; other site 272620014756 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272620014757 hypothetical protein; Provisional; Region: PRK11622 272620014758 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620014759 dimer interface [polypeptide binding]; other site 272620014760 conserved gate region; other site 272620014761 putative PBP binding loops; other site 272620014762 ABC-ATPase subunit interface; other site 272620014763 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272620014764 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620014765 dimer interface [polypeptide binding]; other site 272620014766 conserved gate region; other site 272620014767 putative PBP binding loops; other site 272620014768 ABC-ATPase subunit interface; other site 272620014769 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 272620014770 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620014771 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620014772 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 272620014773 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620014774 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 272620014775 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 272620014776 DNA binding residues [nucleotide binding] 272620014777 dimer interface [polypeptide binding]; other site 272620014778 [2Fe-2S] cluster binding site [ion binding]; other site 272620014779 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 272620014780 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 272620014781 putative C-terminal domain interface [polypeptide binding]; other site 272620014782 putative GSH binding site (G-site) [chemical binding]; other site 272620014783 putative dimer interface [polypeptide binding]; other site 272620014784 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 272620014785 putative N-terminal domain interface [polypeptide binding]; other site 272620014786 putative dimer interface [polypeptide binding]; other site 272620014787 putative substrate binding pocket (H-site) [chemical binding]; other site 272620014788 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 272620014789 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 272620014790 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 272620014791 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620014792 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620014793 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 272620014794 putative dimerization interface [polypeptide binding]; other site 272620014795 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 272620014796 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 272620014797 Fimbrial protein; Region: Fimbrial; cl01416 272620014798 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 272620014799 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620014800 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620014801 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620014802 PapC N-terminal domain; Region: PapC_N; pfam13954 272620014803 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620014804 PapC C-terminal domain; Region: PapC_C; pfam13953 272620014805 Fimbrial protein; Region: Fimbrial; cl01416 272620014806 putative major fimbrial protein SthE; Provisional; Region: PRK15292 272620014807 Fimbrial protein; Region: Fimbrial; pfam00419 272620014808 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 272620014809 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 272620014810 Na binding site [ion binding]; other site 272620014811 Predicted membrane protein [Function unknown]; Region: COG3162 272620014812 acetyl-CoA synthetase; Provisional; Region: PRK00174 272620014813 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 272620014814 active site 272620014815 CoA binding site [chemical binding]; other site 272620014816 acyl-activating enzyme (AAE) consensus motif; other site 272620014817 AMP binding site [chemical binding]; other site 272620014818 acetate binding site [chemical binding]; other site 272620014819 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 272620014820 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 272620014821 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 272620014822 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 272620014823 molybdopterin cofactor binding site; other site 272620014824 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 272620014825 molybdopterin cofactor binding site; other site 272620014826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272620014827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620014828 active site 272620014829 phosphorylation site [posttranslational modification] 272620014830 intermolecular recognition site; other site 272620014831 dimerization interface [polypeptide binding]; other site 272620014832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620014833 DNA binding site [nucleotide binding] 272620014834 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272620014835 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 272620014836 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272620014837 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 272620014838 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620014839 substrate binding site [chemical binding]; other site 272620014840 ATP binding site [chemical binding]; other site 272620014841 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620014842 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 272620014843 putative ligand binding site [chemical binding]; other site 272620014844 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620014845 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620014846 TM-ABC transporter signature motif; other site 272620014847 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620014848 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620014849 Walker A/P-loop; other site 272620014850 ATP binding site [chemical binding]; other site 272620014851 Q-loop/lid; other site 272620014852 ABC transporter signature motif; other site 272620014853 Walker B; other site 272620014854 D-loop; other site 272620014855 H-loop/switch region; other site 272620014856 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620014857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620014858 dimerization interface [polypeptide binding]; other site 272620014859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620014860 dimer interface [polypeptide binding]; other site 272620014861 phosphorylation site [posttranslational modification] 272620014862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620014863 ATP binding site [chemical binding]; other site 272620014864 Mg2+ binding site [ion binding]; other site 272620014865 G-X-G motif; other site 272620014866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620014867 active site 272620014868 phosphorylation site [posttranslational modification] 272620014869 intermolecular recognition site; other site 272620014870 putative hydrolase; Provisional; Region: PRK02113 272620014871 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 272620014872 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 272620014873 active site 272620014874 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 272620014875 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272620014876 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 272620014877 active site 272620014878 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 272620014879 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620014880 Walker A/P-loop; other site 272620014881 ATP binding site [chemical binding]; other site 272620014882 Q-loop/lid; other site 272620014883 ABC transporter signature motif; other site 272620014884 Walker B; other site 272620014885 D-loop; other site 272620014886 H-loop/switch region; other site 272620014887 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 272620014888 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272620014889 Walker A/P-loop; other site 272620014890 ATP binding site [chemical binding]; other site 272620014891 Q-loop/lid; other site 272620014892 ABC transporter signature motif; other site 272620014893 Walker B; other site 272620014894 D-loop; other site 272620014895 H-loop/switch region; other site 272620014896 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272620014897 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 272620014898 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 272620014899 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 272620014900 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 272620014901 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 272620014902 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620014903 DNA-binding site [nucleotide binding]; DNA binding site 272620014904 UTRA domain; Region: UTRA; pfam07702 272620014905 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 272620014906 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 272620014907 dimer interface [polypeptide binding]; other site 272620014908 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 272620014909 PhnA protein; Region: PhnA; pfam03831 272620014910 proline/glycine betaine transporter; Provisional; Region: PRK10642 272620014911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620014912 putative substrate translocation pore; other site 272620014913 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 272620014914 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 272620014915 Cupin domain; Region: Cupin_2; cl17218 272620014916 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620014917 alpha-galactosidase; Provisional; Region: PRK15076 272620014918 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 272620014919 NAD binding site [chemical binding]; other site 272620014920 sugar binding site [chemical binding]; other site 272620014921 divalent metal binding site [ion binding]; other site 272620014922 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620014923 dimer interface [polypeptide binding]; other site 272620014924 melibiose:sodium symporter; Provisional; Region: PRK10429 272620014925 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 272620014926 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272620014927 PRTRC system protein D; Region: PRTRC_D; TIGR03739 272620014928 Mg binding site [ion binding]; other site 272620014929 nucleotide binding site [chemical binding]; other site 272620014930 putative protofilament interface [polypeptide binding]; other site 272620014931 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 272620014932 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 272620014933 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 272620014934 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272620014935 HSP70 interaction site [polypeptide binding]; other site 272620014936 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272620014937 substrate binding site [polypeptide binding]; other site 272620014938 dimer interface [polypeptide binding]; other site 272620014939 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 272620014940 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 272620014941 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 272620014942 catalytic residues [active] 272620014943 N-glycosyltransferase; Provisional; Region: PRK11204 272620014944 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 272620014945 DXD motif; other site 272620014946 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 272620014947 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 272620014948 putative active site [active] 272620014949 putative metal binding site [ion binding]; other site 272620014950 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 272620014951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272620014952 dimerization interface [polypeptide binding]; other site 272620014953 DNA binding residues [nucleotide binding] 272620014954 PerC transcriptional activator; Region: PerC; pfam06069 272620014955 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 272620014956 PAAR motif; Region: PAAR_motif; pfam05488 272620014957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620014958 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620014959 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620014960 putative transposase OrfB; Reviewed; Region: PHA02517 272620014961 HTH-like domain; Region: HTH_21; pfam13276 272620014962 Integrase core domain; Region: rve; pfam00665 272620014963 Integrase core domain; Region: rve_2; pfam13333 272620014964 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 272620014965 putative transcriptional regulator; Provisional; Region: PRK11640 272620014966 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 272620014967 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 272620014968 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 272620014969 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 272620014970 DsbD alpha interface [polypeptide binding]; other site 272620014971 catalytic residues [active] 272620014972 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 272620014973 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 272620014974 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 272620014975 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 272620014976 Aspartase; Region: Aspartase; cd01357 272620014977 active sites [active] 272620014978 tetramer interface [polypeptide binding]; other site 272620014979 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 272620014980 putative transporter; Provisional; Region: PRK11021 272620014981 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272620014982 oligomerisation interface [polypeptide binding]; other site 272620014983 mobile loop; other site 272620014984 roof hairpin; other site 272620014985 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272620014986 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272620014987 ring oligomerisation interface [polypeptide binding]; other site 272620014988 ATP/Mg binding site [chemical binding]; other site 272620014989 stacking interactions; other site 272620014990 hinge regions; other site 272620014991 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 272620014992 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272620014993 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 272620014994 putative active site [active] 272620014995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272620014996 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 272620014997 Walker A/P-loop; other site 272620014998 ATP binding site [chemical binding]; other site 272620014999 Q-loop/lid; other site 272620015000 ABC transporter signature motif; other site 272620015001 Walker B; other site 272620015002 D-loop; other site 272620015003 H-loop/switch region; other site 272620015004 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272620015005 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620015006 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620015007 Fimbrial protein; Region: Fimbrial; pfam00419 272620015008 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 272620015009 PapC N-terminal domain; Region: PapC_N; pfam13954 272620015010 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 272620015011 PapC C-terminal domain; Region: PapC_C; pfam13953 272620015012 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 272620015013 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 272620015014 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 272620015015 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 272620015016 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272620015017 DNA binding site [nucleotide binding] 272620015018 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 272620015019 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620015020 FeS/SAM binding site; other site 272620015021 elongation factor P; Validated; Region: PRK00529 272620015022 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272620015023 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272620015024 RNA binding site [nucleotide binding]; other site 272620015025 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272620015026 RNA binding site [nucleotide binding]; other site 272620015027 Predicted small secreted protein [Function unknown]; Region: COG5510 272620015028 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 272620015029 multidrug efflux system protein; Provisional; Region: PRK11431 272620015030 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 272620015031 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 272620015032 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 272620015033 Iron-sulfur protein interface; other site 272620015034 proximal quinone binding site [chemical binding]; other site 272620015035 C-subunit interface; other site 272620015036 distal quinone binding site; other site 272620015037 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 272620015038 D-subunit interface [polypeptide binding]; other site 272620015039 Iron-sulfur protein interface; other site 272620015040 proximal quinone binding site [chemical binding]; other site 272620015041 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 272620015042 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 272620015043 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 272620015044 L-aspartate oxidase; Provisional; Region: PRK06175 272620015045 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 272620015046 poxB regulator PoxA; Provisional; Region: PRK09350 272620015047 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272620015048 motif 1; other site 272620015049 dimer interface [polypeptide binding]; other site 272620015050 active site 272620015051 motif 2; other site 272620015052 motif 3; other site 272620015053 inner membrane transporter YjeM; Provisional; Region: PRK15238 272620015054 putative mechanosensitive channel protein; Provisional; Region: PRK10929 272620015055 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 272620015056 putative YPXnL-motif binding site; other site 272620015057 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 272620015058 Mechanosensitive ion channel; Region: MS_channel; pfam00924 272620015059 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 272620015060 GTPase RsgA; Reviewed; Region: PRK12288 272620015061 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272620015062 RNA binding site [nucleotide binding]; other site 272620015063 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272620015064 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272620015065 GTP/Mg2+ binding site [chemical binding]; other site 272620015066 G4 box; other site 272620015067 G5 box; other site 272620015068 G1 box; other site 272620015069 Switch I region; other site 272620015070 G2 box; other site 272620015071 G3 box; other site 272620015072 Switch II region; other site 272620015073 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 272620015074 catalytic site [active] 272620015075 putative active site [active] 272620015076 putative substrate binding site [chemical binding]; other site 272620015077 dimer interface [polypeptide binding]; other site 272620015078 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 272620015079 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620015080 substrate binding pocket [chemical binding]; other site 272620015081 membrane-bound complex binding site; other site 272620015082 hinge residues; other site 272620015083 epoxyqueuosine reductase; Region: TIGR00276 272620015084 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 272620015085 putative carbohydrate kinase; Provisional; Region: PRK10565 272620015086 Uncharacterized conserved protein [Function unknown]; Region: COG0062 272620015087 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 272620015088 putative substrate binding site [chemical binding]; other site 272620015089 putative ATP binding site [chemical binding]; other site 272620015090 ADP-binding protein; Provisional; Region: PRK10646 272620015091 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 272620015092 AMIN domain; Region: AMIN; pfam11741 272620015093 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 272620015094 active site 272620015095 metal binding site [ion binding]; metal-binding site 272620015096 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 272620015097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620015098 ATP binding site [chemical binding]; other site 272620015099 Mg2+ binding site [ion binding]; other site 272620015100 G-X-G motif; other site 272620015101 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 272620015102 ATP binding site [chemical binding]; other site 272620015103 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 272620015104 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272620015105 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272620015106 bacterial Hfq-like; Region: Hfq; cd01716 272620015107 hexamer interface [polypeptide binding]; other site 272620015108 Sm1 motif; other site 272620015109 RNA binding site [nucleotide binding]; other site 272620015110 Sm2 motif; other site 272620015111 GTPase HflX; Provisional; Region: PRK11058 272620015112 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 272620015113 HflX GTPase family; Region: HflX; cd01878 272620015114 G1 box; other site 272620015115 GTP/Mg2+ binding site [chemical binding]; other site 272620015116 Switch I region; other site 272620015117 G2 box; other site 272620015118 G3 box; other site 272620015119 Switch II region; other site 272620015120 G4 box; other site 272620015121 G5 box; other site 272620015122 FtsH protease regulator HflK; Provisional; Region: PRK10930 272620015123 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 272620015124 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 272620015125 FtsH protease regulator HflC; Provisional; Region: PRK11029 272620015126 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 272620015127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 272620015128 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272620015129 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272620015130 GDP-binding site [chemical binding]; other site 272620015131 ACT binding site; other site 272620015132 IMP binding site; other site 272620015133 Predicted transcriptional regulator [Transcription]; Region: COG1959 272620015134 transcriptional repressor NsrR; Provisional; Region: PRK11014 272620015135 exoribonuclease R; Provisional; Region: PRK11642 272620015136 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 272620015137 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272620015138 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272620015139 RNB domain; Region: RNB; pfam00773 272620015140 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272620015141 RNA binding site [nucleotide binding]; other site 272620015142 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 272620015143 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272620015144 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272620015145 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 272620015146 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 272620015147 FAD binding site [chemical binding]; other site 272620015148 substrate binding site [chemical binding]; other site 272620015149 catalytic residues [active] 272620015150 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620015151 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 272620015152 esterase; Provisional; Region: PRK10566 272620015153 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 272620015154 transcriptional repressor UlaR; Provisional; Region: PRK13509 272620015155 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 272620015156 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620015157 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 272620015158 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 272620015159 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 272620015160 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272620015161 active site 272620015162 P-loop; other site 272620015163 phosphorylation site [posttranslational modification] 272620015164 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620015165 active site 272620015166 phosphorylation site [posttranslational modification] 272620015167 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 272620015168 active site 272620015169 dimer interface [polypeptide binding]; other site 272620015170 magnesium binding site [ion binding]; other site 272620015171 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 272620015172 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272620015173 AP (apurinic/apyrimidinic) site pocket; other site 272620015174 DNA interaction; other site 272620015175 Metal-binding active site; metal-binding site 272620015176 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 272620015177 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 272620015178 intersubunit interface [polypeptide binding]; other site 272620015179 active site 272620015180 Zn2+ binding site [ion binding]; other site 272620015181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620015182 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620015183 putative substrate translocation pore; other site 272620015184 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 272620015185 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272620015186 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272620015187 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272620015188 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272620015189 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272620015190 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272620015191 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 272620015192 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 272620015193 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 272620015194 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 272620015195 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272620015196 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 272620015197 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 272620015198 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 272620015199 Hemerythrin-like domain; Region: Hr-like; cd12108 272620015200 Fe binding site [ion binding]; other site 272620015201 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 272620015202 EamA-like transporter family; Region: EamA; pfam00892 272620015203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620015204 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 272620015205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015207 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 272620015208 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 272620015209 NADP binding site [chemical binding]; other site 272620015210 Predicted transcriptional regulators [Transcription]; Region: COG1733 272620015211 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 272620015212 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 272620015213 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 272620015214 active site 272620015215 metal binding site [ion binding]; metal-binding site 272620015216 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 272620015217 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 272620015218 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 272620015219 active site 272620015220 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 272620015221 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 272620015222 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 272620015223 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620015224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015225 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015226 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 272620015227 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 272620015228 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 272620015229 galactoside permease; Reviewed; Region: lacY; PRK09528 272620015230 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272620015231 Domain of unknown function DUF21; Region: DUF21; pfam01595 272620015232 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272620015233 Transporter associated domain; Region: CorC_HlyC; smart01091 272620015234 methionine sulfoxide reductase A; Provisional; Region: PRK00058 272620015235 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 272620015236 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 272620015237 Surface antigen; Region: Bac_surface_Ag; pfam01103 272620015238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 272620015239 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 272620015240 Family of unknown function (DUF490); Region: DUF490; pfam04357 272620015241 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 272620015242 dimerization interface [polypeptide binding]; other site 272620015243 putative active site pocket [active] 272620015244 putative catalytic residue [active] 272620015245 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272620015246 dimer interface [polypeptide binding]; other site 272620015247 substrate binding site [chemical binding]; other site 272620015248 metal binding sites [ion binding]; metal-binding site 272620015249 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 272620015250 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 272620015251 putative ligand binding site [chemical binding]; other site 272620015252 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620015253 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620015254 Walker A/P-loop; other site 272620015255 ATP binding site [chemical binding]; other site 272620015256 Q-loop/lid; other site 272620015257 ABC transporter signature motif; other site 272620015258 Walker B; other site 272620015259 D-loop; other site 272620015260 H-loop/switch region; other site 272620015261 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620015262 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620015263 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620015264 TM-ABC transporter signature motif; other site 272620015265 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620015266 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620015267 TM-ABC transporter signature motif; other site 272620015268 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 272620015269 AMP binding site [chemical binding]; other site 272620015270 metal binding site [ion binding]; metal-binding site 272620015271 active site 272620015272 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 272620015273 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 272620015274 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 272620015275 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272620015276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 272620015277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620015278 Coenzyme A binding pocket [chemical binding]; other site 272620015279 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 272620015280 active site 272620015281 catalytic residues [active] 272620015282 hypothetical protein; Provisional; Region: PRK05255 272620015283 peptidase PmbA; Provisional; Region: PRK11040 272620015284 Cytochrome b562; Region: Cytochrom_B562; cl01546 272620015285 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 272620015286 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 272620015287 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 272620015288 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 272620015289 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 272620015290 dihydroorotase; Provisional; Region: PRK09237 272620015291 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 272620015292 active site 272620015293 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 272620015294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272620015295 catalytic residue [active] 272620015296 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 272620015297 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 272620015298 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272620015299 HTH domain; Region: HTH_11; pfam08279 272620015300 Mga helix-turn-helix domain; Region: Mga; pfam05043 272620015301 PRD domain; Region: PRD; pfam00874 272620015302 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 272620015303 active site 272620015304 P-loop; other site 272620015305 phosphorylation site [posttranslational modification] 272620015306 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272620015307 active site 272620015308 phosphorylation site [posttranslational modification] 272620015309 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 272620015310 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 272620015311 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 272620015312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272620015313 FeS/SAM binding site; other site 272620015314 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 272620015315 ATP cone domain; Region: ATP-cone; pfam03477 272620015316 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272620015317 effector binding site; other site 272620015318 active site 272620015319 Zn binding site [ion binding]; other site 272620015320 glycine loop; other site 272620015321 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620015322 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620015323 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620015324 putative active site [active] 272620015325 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 272620015326 active site 272620015327 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 272620015328 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 272620015329 NAD binding site [chemical binding]; other site 272620015330 sugar binding site [chemical binding]; other site 272620015331 divalent metal binding site [ion binding]; other site 272620015332 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620015333 dimer interface [polypeptide binding]; other site 272620015334 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272620015335 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 272620015336 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 272620015337 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 272620015338 Ca binding site [ion binding]; other site 272620015339 active site 272620015340 catalytic site [active] 272620015341 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 272620015342 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 272620015343 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272620015344 active site turn [active] 272620015345 phosphorylation site [posttranslational modification] 272620015346 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272620015347 trehalose repressor; Provisional; Region: treR; PRK09492 272620015348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620015349 DNA binding site [nucleotide binding] 272620015350 domain linker motif; other site 272620015351 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 272620015352 dimerization interface [polypeptide binding]; other site 272620015353 ligand binding site [chemical binding]; other site 272620015354 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 272620015355 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272620015356 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620015357 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272620015358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620015359 motif II; other site 272620015360 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272620015361 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272620015362 homotrimer interaction site [polypeptide binding]; other site 272620015363 putative active site [active] 272620015364 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 272620015365 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 272620015366 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 272620015367 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 272620015368 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272620015369 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272620015370 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 272620015371 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 272620015372 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272620015373 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272620015374 RNase E inhibitor protein; Provisional; Region: PRK11191 272620015375 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 272620015376 active site 272620015377 dinuclear metal binding site [ion binding]; other site 272620015378 dimerization interface [polypeptide binding]; other site 272620015379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620015380 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272620015381 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272620015382 HIGH motif; other site 272620015383 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272620015384 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272620015385 active site 272620015386 KMSKS motif; other site 272620015387 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272620015388 tRNA binding surface [nucleotide binding]; other site 272620015389 anticodon binding site; other site 272620015390 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272620015391 DNA polymerase III subunit chi; Validated; Region: PRK05728 272620015392 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272620015393 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272620015394 interface (dimer of trimers) [polypeptide binding]; other site 272620015395 Substrate-binding/catalytic site; other site 272620015396 Zn-binding sites [ion binding]; other site 272620015397 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 272620015398 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272620015399 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 272620015400 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 272620015401 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 272620015402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272620015403 Walker A motif; other site 272620015404 ATP binding site [chemical binding]; other site 272620015405 Walker B motif; other site 272620015406 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 272620015407 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 272620015408 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 272620015409 tetrameric interface [polypeptide binding]; other site 272620015410 NAD binding site [chemical binding]; other site 272620015411 catalytic residues [active] 272620015412 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 272620015413 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620015414 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620015415 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620015416 putative active site [active] 272620015417 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 272620015418 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 272620015419 substrate binding site [chemical binding]; other site 272620015420 ATP binding site [chemical binding]; other site 272620015421 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 272620015422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 272620015423 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 272620015424 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 272620015425 PYR/PP interface [polypeptide binding]; other site 272620015426 dimer interface [polypeptide binding]; other site 272620015427 TPP binding site [chemical binding]; other site 272620015428 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272620015429 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 272620015430 TPP-binding site; other site 272620015431 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 272620015432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 272620015433 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 272620015434 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 272620015435 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 272620015436 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 272620015437 Metal-binding active site; metal-binding site 272620015438 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272620015439 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 272620015440 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272620015441 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 272620015442 Walker A/P-loop; other site 272620015443 ATP binding site [chemical binding]; other site 272620015444 Q-loop/lid; other site 272620015445 ABC transporter signature motif; other site 272620015446 Walker B; other site 272620015447 D-loop; other site 272620015448 H-loop/switch region; other site 272620015449 TOBE domain; Region: TOBE_2; pfam08402 272620015450 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 272620015451 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272620015452 active site 272620015453 metal binding site [ion binding]; metal-binding site 272620015454 hexamer interface [polypeptide binding]; other site 272620015455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272620015456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620015457 dimer interface [polypeptide binding]; other site 272620015458 conserved gate region; other site 272620015459 putative PBP binding loops; other site 272620015460 ABC-ATPase subunit interface; other site 272620015461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620015462 dimer interface [polypeptide binding]; other site 272620015463 conserved gate region; other site 272620015464 putative PBP binding loops; other site 272620015465 ABC-ATPase subunit interface; other site 272620015466 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272620015467 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 272620015468 putative NAD(P) binding site [chemical binding]; other site 272620015469 putative substrate binding site [chemical binding]; other site 272620015470 catalytic Zn binding site [ion binding]; other site 272620015471 structural Zn binding site [ion binding]; other site 272620015472 dimer interface [polypeptide binding]; other site 272620015473 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272620015474 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272620015475 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272620015476 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272620015477 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272620015478 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 272620015479 active site clefts [active] 272620015480 zinc binding site [ion binding]; other site 272620015481 dimer interface [polypeptide binding]; other site 272620015482 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 272620015483 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 272620015484 active site 272620015485 Int/Topo IB signature motif; other site 272620015486 Methyltransferase domain; Region: Methyltransf_23; pfam13489 272620015487 Methyltransferase domain; Region: Methyltransf_12; pfam08242 272620015488 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272620015489 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620015490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620015491 non-specific DNA binding site [nucleotide binding]; other site 272620015492 salt bridge; other site 272620015493 sequence-specific DNA binding site [nucleotide binding]; other site 272620015494 HipA N-terminal domain; Region: couple_hipA; TIGR03071 272620015495 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 272620015496 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620015497 active site 272620015498 Putative helicase; Region: TraI_2; pfam07514 272620015499 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272620015500 Zn2+ binding site [ion binding]; other site 272620015501 Mg2+ binding site [ion binding]; other site 272620015502 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 272620015503 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 272620015504 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 272620015505 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 272620015506 ParB-like nuclease domain; Region: ParBc; pfam02195 272620015507 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 272620015508 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 272620015509 HNH endonuclease; Region: HNH_2; pfam13391 272620015510 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 272620015511 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272620015512 cofactor binding site; other site 272620015513 DNA binding site [nucleotide binding] 272620015514 substrate interaction site [chemical binding]; other site 272620015515 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620015516 ATP binding site [chemical binding]; other site 272620015517 putative Mg++ binding site [ion binding]; other site 272620015518 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272620015519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620015520 nucleotide binding region [chemical binding]; other site 272620015521 ATP-binding site [chemical binding]; other site 272620015522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620015523 ATP-binding site [chemical binding]; other site 272620015524 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 272620015525 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272620015526 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272620015527 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620015528 active site 272620015529 HTH-like domain; Region: HTH_21; pfam13276 272620015530 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 272620015531 HNH endonuclease; Region: HNH_2; pfam13391 272620015532 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620015533 active site 272620015534 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 272620015535 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 272620015536 inhibitor binding site; inhibition site 272620015537 active site 272620015538 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272620015539 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 272620015540 xylose isomerase; Provisional; Region: PRK05474 272620015541 xylose isomerase; Region: xylose_isom_A; TIGR02630 272620015542 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 272620015543 Protein of unknown function (DUF523); Region: DUF523; pfam04463 272620015544 Uncharacterized conserved protein [Function unknown]; Region: COG3272 272620015545 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 272620015546 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 272620015547 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 272620015548 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 272620015549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620015550 S-adenosylmethionine binding site [chemical binding]; other site 272620015551 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 272620015552 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 272620015553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272620015554 short chain dehydrogenase; Provisional; Region: PRK06101 272620015555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272620015556 NAD(P) binding site [chemical binding]; other site 272620015557 active site 272620015558 transcriptional regulator MirA; Provisional; Region: PRK15043 272620015559 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 272620015560 DNA binding residues [nucleotide binding] 272620015561 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 272620015562 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 272620015563 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 272620015564 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 272620015565 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 272620015566 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620015567 periplasmic copper-binding protein; Provisional; Region: PRK09838 272620015568 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 272620015569 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 272620015570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620015571 active site 272620015572 phosphorylation site [posttranslational modification] 272620015573 intermolecular recognition site; other site 272620015574 dimerization interface [polypeptide binding]; other site 272620015575 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620015576 DNA binding site [nucleotide binding] 272620015577 sensor kinase CusS; Provisional; Region: PRK09835 272620015578 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620015579 dimerization interface [polypeptide binding]; other site 272620015580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620015581 dimer interface [polypeptide binding]; other site 272620015582 phosphorylation site [posttranslational modification] 272620015583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620015584 ATP binding site [chemical binding]; other site 272620015585 Mg2+ binding site [ion binding]; other site 272620015586 G-X-G motif; other site 272620015587 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620015588 Uncharacterized conserved protein [Function unknown]; Region: COG2850 272620015589 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 272620015590 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272620015591 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 272620015592 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272620015593 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272620015594 Walker A/P-loop; other site 272620015595 ATP binding site [chemical binding]; other site 272620015596 Q-loop/lid; other site 272620015597 ABC transporter signature motif; other site 272620015598 Walker B; other site 272620015599 D-loop; other site 272620015600 H-loop/switch region; other site 272620015601 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272620015602 Walker A/P-loop; other site 272620015603 ATP binding site [chemical binding]; other site 272620015604 Q-loop/lid; other site 272620015605 ABC transporter signature motif; other site 272620015606 Walker B; other site 272620015607 D-loop; other site 272620015608 H-loop/switch region; other site 272620015609 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 272620015610 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 272620015611 HlyD family secretion protein; Region: HlyD; pfam00529 272620015612 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620015613 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620015614 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272620015615 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272620015616 active site 272620015617 HIGH motif; other site 272620015618 dimer interface [polypeptide binding]; other site 272620015619 KMSKS motif; other site 272620015620 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 272620015621 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 272620015622 ligand binding site [chemical binding]; other site 272620015623 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 272620015624 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272620015625 Walker A/P-loop; other site 272620015626 ATP binding site [chemical binding]; other site 272620015627 Q-loop/lid; other site 272620015628 ABC transporter signature motif; other site 272620015629 Walker B; other site 272620015630 D-loop; other site 272620015631 H-loop/switch region; other site 272620015632 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272620015633 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620015634 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620015635 TM-ABC transporter signature motif; other site 272620015636 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272620015637 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 272620015638 TM-ABC transporter signature motif; other site 272620015639 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 272620015640 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272620015641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620015642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620015643 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 272620015644 putative substrate binding pocket [chemical binding]; other site 272620015645 putative dimerization interface [polypeptide binding]; other site 272620015646 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 272620015647 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 272620015648 dimer interface [polypeptide binding]; other site 272620015649 Mn binding site [ion binding]; other site 272620015650 K binding site [ion binding]; other site 272620015651 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 272620015652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272620015653 DNA-binding site [nucleotide binding]; DNA binding site 272620015654 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272620015655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272620015656 homodimer interface [polypeptide binding]; other site 272620015657 catalytic residue [active] 272620015658 transcriptional regulator SlyA; Provisional; Region: PRK03573 272620015659 MarR family; Region: MarR_2; cl17246 272620015660 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 272620015661 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 272620015662 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 272620015663 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 272620015664 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 272620015665 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 272620015666 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 272620015667 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 272620015668 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 272620015669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620015670 putative substrate translocation pore; other site 272620015671 Protein of unknown function (DUF445); Region: DUF445; pfam04286 272620015672 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 272620015673 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 272620015674 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 272620015675 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015676 hypothetical protein; Provisional; Region: PRK09956 272620015677 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620015678 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 272620015679 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 272620015680 NAD(P) binding site [chemical binding]; other site 272620015681 catalytic residues [active] 272620015682 YfaZ precursor; Region: YfaZ; pfam07437 272620015683 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 272620015684 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 272620015685 P-loop, Walker A motif; other site 272620015686 Base recognition motif; other site 272620015687 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 272620015688 Uncharacterized small protein [Function unknown]; Region: COG2879 272620015689 carbon starvation protein A; Provisional; Region: PRK15015 272620015690 Carbon starvation protein CstA; Region: CstA; pfam02554 272620015691 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 272620015692 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 272620015693 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 272620015694 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 272620015695 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 272620015696 Cupin domain; Region: Cupin_2; pfam07883 272620015697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015698 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 272620015699 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620015700 putative substrate translocation pore; other site 272620015701 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 272620015702 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 272620015703 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 272620015704 putative substrate binding pocket [chemical binding]; other site 272620015705 trimer interface [polypeptide binding]; other site 272620015706 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 272620015707 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 272620015708 putative active site [active] 272620015709 putative metal binding site [ion binding]; other site 272620015710 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 272620015711 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 272620015712 NAD binding site [chemical binding]; other site 272620015713 catalytic residues [active] 272620015714 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 272620015715 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 272620015716 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 272620015717 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272620015718 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 272620015719 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 272620015720 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 272620015721 dimer interface [polypeptide binding]; other site 272620015722 active site 272620015723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 272620015724 substrate binding site [chemical binding]; other site 272620015725 catalytic residue [active] 272620015726 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 272620015727 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 272620015728 active site 272620015729 putative substrate binding pocket [chemical binding]; other site 272620015730 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272620015731 homotrimer interaction site [polypeptide binding]; other site 272620015732 putative active site [active] 272620015733 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 272620015734 Na binding site [ion binding]; other site 272620015735 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 272620015736 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 272620015737 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 272620015738 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 272620015739 active site 272620015740 intersubunit interface [polypeptide binding]; other site 272620015741 catalytic residue [active] 272620015742 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272620015743 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272620015744 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272620015745 putative active site [active] 272620015746 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 272620015747 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620015748 Coenzyme A binding pocket [chemical binding]; other site 272620015749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620015750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272620015751 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 272620015752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620015753 Walker A motif; other site 272620015754 ATP binding site [chemical binding]; other site 272620015755 Walker B motif; other site 272620015756 arginine finger; other site 272620015757 Transcriptional antiterminator [Transcription]; Region: COG3933 272620015758 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620015759 active pocket/dimerization site; other site 272620015760 active site 272620015761 phosphorylation site [posttranslational modification] 272620015762 PRD domain; Region: PRD; pfam00874 272620015763 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 272620015764 active pocket/dimerization site; other site 272620015765 active site 272620015766 phosphorylation site [posttranslational modification] 272620015767 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 272620015768 active site 272620015769 phosphorylation site [posttranslational modification] 272620015770 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 272620015771 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 272620015772 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272620015773 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 272620015774 dimer interface [polypeptide binding]; other site 272620015775 active site 272620015776 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 272620015777 dimer interface [polypeptide binding]; other site 272620015778 active site 272620015779 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 272620015780 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 272620015781 putative active site [active] 272620015782 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272620015783 putative transposase; Provisional; Region: PRK09857 272620015784 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 272620015785 phosphoglycerol transferase I; Provisional; Region: PRK03776 272620015786 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 272620015787 hypothetical protein; Provisional; Region: PRK11667 272620015788 DNA replication protein DnaC; Validated; Region: PRK07952 272620015789 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620015790 Walker A motif; other site 272620015791 ATP binding site [chemical binding]; other site 272620015792 Walker B motif; other site 272620015793 primosomal protein DnaI; Provisional; Region: PRK02854 272620015794 hypothetical protein; Provisional; Region: PRK09917 272620015795 Uncharacterized conserved protein [Function unknown]; Region: COG2966 272620015796 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 272620015797 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 272620015798 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 272620015799 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 272620015800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015801 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 272620015802 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620015803 DNA binding residues [nucleotide binding] 272620015804 dimerization interface [polypeptide binding]; other site 272620015805 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 272620015806 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 272620015807 DNA binding residues [nucleotide binding] 272620015808 dimerization interface [polypeptide binding]; other site 272620015809 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 272620015810 putative deacylase active site [active] 272620015811 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 272620015812 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 272620015813 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 272620015814 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 272620015815 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 272620015816 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620015817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620015818 metal binding site [ion binding]; metal-binding site 272620015819 active site 272620015820 I-site; other site 272620015821 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 272620015822 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 272620015823 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 272620015824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620015825 DNA polymerase III subunit psi; Validated; Region: PRK06856 272620015826 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 272620015827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620015828 Coenzyme A binding pocket [chemical binding]; other site 272620015829 dUMP phosphatase; Provisional; Region: PRK09449 272620015830 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620015831 motif II; other site 272620015832 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 272620015833 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 272620015834 G1 box; other site 272620015835 putative GEF interaction site [polypeptide binding]; other site 272620015836 GTP/Mg2+ binding site [chemical binding]; other site 272620015837 Switch I region; other site 272620015838 G2 box; other site 272620015839 G3 box; other site 272620015840 Switch II region; other site 272620015841 G4 box; other site 272620015842 G5 box; other site 272620015843 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 272620015844 periplasmic protein; Provisional; Region: PRK10568 272620015845 BON domain; Region: BON; pfam04972 272620015846 BON domain; Region: BON; cl02771 272620015847 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 272620015848 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 272620015849 active site 272620015850 nucleophile elbow; other site 272620015851 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272620015852 active site 272620015853 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 272620015854 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 272620015855 Nucleoside recognition; Region: Gate; pfam07670 272620015856 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 272620015857 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272620015858 intersubunit interface [polypeptide binding]; other site 272620015859 active site 272620015860 catalytic residue [active] 272620015861 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 272620015862 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272620015863 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272620015864 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272620015865 phosphopentomutase; Provisional; Region: PRK05362 272620015866 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 272620015867 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 272620015868 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272620015869 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 272620015870 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272620015871 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272620015872 hypothetical protein; Provisional; Region: PRK11246 272620015873 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 272620015874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620015875 motif II; other site 272620015876 DNA repair protein RadA; Region: sms; TIGR00416 272620015877 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 272620015878 Walker A motif/ATP binding site; other site 272620015879 ATP binding site [chemical binding]; other site 272620015880 Walker B motif; other site 272620015881 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 272620015882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620015883 non-specific DNA binding site [nucleotide binding]; other site 272620015884 salt bridge; other site 272620015885 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 272620015886 sequence-specific DNA binding site [nucleotide binding]; other site 272620015887 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 272620015888 active site 272620015889 (T/H)XGH motif; other site 272620015890 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 272620015891 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 272620015892 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620015893 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620015894 ABC transporter; Region: ABC_tran_2; pfam12848 272620015895 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272620015896 lytic murein transglycosylase; Provisional; Region: PRK11619 272620015897 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620015898 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620015899 catalytic residue [active] 272620015900 Trp operon repressor; Provisional; Region: PRK01381 272620015901 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 272620015902 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 272620015903 catalytic core [active] 272620015904 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 272620015905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 272620015906 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 272620015907 hypothetical protein; Provisional; Region: PRK10756 272620015908 CreA protein; Region: CreA; pfam05981 272620015909 DNA-binding response regulator CreB; Provisional; Region: PRK11083 272620015910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620015911 active site 272620015912 phosphorylation site [posttranslational modification] 272620015913 intermolecular recognition site; other site 272620015914 dimerization interface [polypeptide binding]; other site 272620015915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620015916 DNA binding site [nucleotide binding] 272620015917 sensory histidine kinase CreC; Provisional; Region: PRK11100 272620015918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620015919 dimer interface [polypeptide binding]; other site 272620015920 phosphorylation site [posttranslational modification] 272620015921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620015922 ATP binding site [chemical binding]; other site 272620015923 Mg2+ binding site [ion binding]; other site 272620015924 G-X-G motif; other site 272620015925 Inner membrane protein CreD; Region: CreD; pfam06123 272620015926 two-component response regulator; Provisional; Region: PRK11173 272620015927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620015928 active site 272620015929 phosphorylation site [posttranslational modification] 272620015930 intermolecular recognition site; other site 272620015931 dimerization interface [polypeptide binding]; other site 272620015932 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620015933 DNA binding site [nucleotide binding] 272620015934 putative RNA methyltransferase; Provisional; Region: PRK10433 272620015935 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 272620015936 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 272620015937 S-type Pyocin; Region: Pyocin_S; pfam06958 272620015938 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620015939 active site 272620015940 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 272620015941 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 272620015942 PLD-like domain; Region: PLDc_2; pfam13091 272620015943 putative active site [active] 272620015944 catalytic site [active] 272620015945 replication protein; Provisional; Region: PRK13702 272620015946 replication protein; Provisional; Region: PRK13750 272620015947 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 272620015948 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272620015949 ATP binding site [chemical binding]; other site 272620015950 putative Mg++ binding site [ion binding]; other site 272620015951 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272620015952 nucleotide binding region [chemical binding]; other site 272620015953 ATP-binding site [chemical binding]; other site 272620015954 P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923 272620015955 AAA ATPase domain; Region: AAA_16; pfam13191 272620015956 Domain of unknown function (DUF4016); Region: DUF4016; pfam13208 272620015957 tellurite resistance protein terB; Region: terB; cd07176 272620015958 putative metal binding site [ion binding]; other site 272620015959 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 272620015960 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272620015961 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 272620015962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620015963 putative substrate translocation pore; other site 272620015964 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 272620015965 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 272620015966 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 272620015967 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 272620015968 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 272620015969 lac repressor; Reviewed; Region: lacI; PRK09526 272620015970 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272620015971 DNA binding site [nucleotide binding] 272620015972 domain linker motif; other site 272620015973 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 272620015974 ligand binding site [chemical binding]; other site 272620015975 dimerization interface (open form) [polypeptide binding]; other site 272620015976 dimerization interface (closed form) [polypeptide binding]; other site 272620015977 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 272620015978 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 272620015979 putative NAD(P) binding site [chemical binding]; other site 272620015980 dimer interface [polypeptide binding]; other site 272620015981 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272620015982 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272620015983 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272620015984 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620015985 DDE domain; Region: DDE_Tnp_IS240; pfam13610 272620015986 Integrase core domain; Region: rve; pfam00665 272620015987 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272620015988 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272620015989 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 272620015990 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 272620015991 Cytochrome b562; Region: Cytochrom_B562; cl01546 272620015992 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 272620015993 Transposase; Region: HTH_Tnp_1; cl17663 272620015994 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620015995 IS2 transposase TnpB; Reviewed; Region: PRK09409 272620015996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272620015997 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272620015998 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272620015999 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 272620016000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016001 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016002 Integrase core domain; Region: rve; pfam00665 272620016003 Transposase domain (DUF772); Region: DUF772; pfam05598 272620016004 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 272620016005 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272620016006 Walker A/P-loop; other site 272620016007 ATP binding site [chemical binding]; other site 272620016008 Q-loop/lid; other site 272620016009 ABC transporter signature motif; other site 272620016010 Walker B; other site 272620016011 D-loop; other site 272620016012 H-loop/switch region; other site 272620016013 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 272620016014 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 272620016015 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272620016016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620016017 dimer interface [polypeptide binding]; other site 272620016018 conserved gate region; other site 272620016019 putative PBP binding loops; other site 272620016020 ABC-ATPase subunit interface; other site 272620016021 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272620016022 Thermostable Phosphite Dehydrogenase; Region: PTDH; cd12157 272620016023 homodimer interface [polypeptide binding]; other site 272620016024 ligand binding site [chemical binding]; other site 272620016025 NAD binding site [chemical binding]; other site 272620016026 catalytic site [active] 272620016027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 272620016028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 272620016029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 272620016030 dimerization interface [polypeptide binding]; other site 272620016031 Transposase domain (DUF772); Region: DUF772; pfam05598 272620016032 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 272620016033 Transposase domain (DUF772); Region: DUF772; pfam05598 272620016034 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 272620016035 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 272620016036 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272620016037 Transposase; Region: HTH_Tnp_1; pfam01527 272620016038 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620016039 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 272620016040 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 272620016041 putative dimer interface [polypeptide binding]; other site 272620016042 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272620016043 Clp amino terminal domain; Region: Clp_N; pfam02861 272620016044 Clp amino terminal domain; Region: Clp_N; pfam02861 272620016045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620016046 Walker A motif; other site 272620016047 ATP binding site [chemical binding]; other site 272620016048 Walker B motif; other site 272620016049 arginine finger; other site 272620016050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272620016051 Walker A motif; other site 272620016052 ATP binding site [chemical binding]; other site 272620016053 Walker B motif; other site 272620016054 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272620016055 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620016056 I-site; other site 272620016057 Phosphate-starvation-inducible E; Region: PsiE; pfam06146 272620016058 Peptidase family M48; Region: Peptidase_M48; cl12018 272620016059 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 272620016060 HTH-like domain; Region: HTH_21; pfam13276 272620016061 Integrase core domain; Region: rve; pfam00665 272620016062 Integrase core domain; Region: rve_2; pfam13333 272620016063 Winged helix-turn helix; Region: HTH_29; pfam13551 272620016064 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620016065 Homeodomain-like domain; Region: HTH_32; pfam13565 272620016066 Integrase core domain; Region: rve; pfam00665 272620016067 Integrase core domain; Region: rve_3; cl15866 272620016068 Winged helix-turn helix; Region: HTH_29; pfam13551 272620016069 Helix-turn-helix domain; Region: HTH_28; pfam13518 272620016070 Homeodomain-like domain; Region: HTH_32; pfam13565 272620016071 Integrase core domain; Region: rve; pfam00665 272620016072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 272620016073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 272620016074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 272620016075 dimerization interface [polypeptide binding]; other site 272620016076 putative DNA binding site [nucleotide binding]; other site 272620016077 putative Zn2+ binding site [ion binding]; other site 272620016078 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 272620016079 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 272620016080 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272620016081 P loop; other site 272620016082 Nucleotide binding site [chemical binding]; other site 272620016083 DTAP/Switch II; other site 272620016084 Switch I; other site 272620016085 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 272620016086 P loop; other site 272620016087 Nucleotide binding site [chemical binding]; other site 272620016088 DTAP/Switch II; other site 272620016089 Switch I; other site 272620016090 arsenical pump membrane protein; Provisional; Region: PRK15445 272620016091 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 272620016092 transmembrane helices; other site 272620016093 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 272620016094 ArsC family; Region: ArsC; pfam03960 272620016095 catalytic residues [active] 272620016096 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272620016097 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620016098 Coenzyme A binding pocket [chemical binding]; other site 272620016099 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 272620016100 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272620016101 RNA polymerase sigma factor, SigZ family; Region: SigZ; TIGR02959 272620016102 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272620016103 DNA binding residues [nucleotide binding] 272620016104 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 272620016105 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272620016106 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 272620016107 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 272620016108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272620016109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272620016110 Coenzyme A binding pocket [chemical binding]; other site 272620016111 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 272620016112 amphipathic channel; other site 272620016113 Asn-Pro-Ala signature motifs; other site 272620016114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272620016115 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272620016116 Homeodomain-like domain; Region: HTH_23; pfam13384 272620016117 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272620016118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272620016119 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 272620016120 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272620016121 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 272620016122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620016123 active site 272620016124 phosphorylation site [posttranslational modification] 272620016125 intermolecular recognition site; other site 272620016126 dimerization interface [polypeptide binding]; other site 272620016127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620016128 DNA binding site [nucleotide binding] 272620016129 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 272620016130 CopC domain; Region: CopC; pfam04234 272620016131 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 272620016132 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 272620016133 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 272620016134 Multicopper oxidase; Region: Cu-oxidase; pfam00394 272620016135 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 272620016136 Peptidase family M23; Region: Peptidase_M23; pfam01551 272620016137 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 272620016138 YHS domain; Region: YHS; pfam04945 272620016139 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 272620016140 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272620016141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272620016142 motif II; other site 272620016143 Protein of unknown function, DUF; Region: DUF411; cl01142 272620016144 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 272620016145 HlyD family secretion protein; Region: HlyD_3; pfam13437 272620016146 periplasmic copper-binding protein; Provisional; Region: PRK09838 272620016147 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 272620016148 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 272620016149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 272620016150 active site 272620016151 phosphorylation site [posttranslational modification] 272620016152 intermolecular recognition site; other site 272620016153 dimerization interface [polypeptide binding]; other site 272620016154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272620016155 DNA binding site [nucleotide binding] 272620016156 sensor kinase CusS; Provisional; Region: PRK09835 272620016157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 272620016158 dimerization interface [polypeptide binding]; other site 272620016159 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 272620016160 dimer interface [polypeptide binding]; other site 272620016161 phosphorylation site [posttranslational modification] 272620016162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272620016163 ATP binding site [chemical binding]; other site 272620016164 Mg2+ binding site [ion binding]; other site 272620016165 G-X-G motif; other site 272620016166 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272620016167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272620016168 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272620016169 Transposase; Region: HTH_Tnp_1; cl17663 272620016170 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620016171 IS2 transposase TnpB; Reviewed; Region: PRK09409 272620016172 HTH-like domain; Region: HTH_21; pfam13276 272620016173 Integrase core domain; Region: rve; pfam00665 272620016174 Integrase core domain; Region: rve_3; pfam13683 272620016175 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272620016176 BCCT family transporter; Region: BCCT; cl00569 272620016177 Predicted membrane protein [Function unknown]; Region: COG4325 272620016178 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 272620016179 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 272620016180 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620016181 Transposase; Region: HTH_Tnp_1; cl17663 272620016182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272620016183 IS2 transposase TnpB; Reviewed; Region: PRK09409 272620016184 HTH-like domain; Region: HTH_21; pfam13276 272620016185 Integrase core domain; Region: rve; pfam00665 272620016186 Integrase core domain; Region: rve_3; pfam13683 272620016187 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 272620016188 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272620016189 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620016190 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 272620016191 GAF domain; Region: GAF; pfam01590 272620016192 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 272620016193 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 272620016194 metal binding site [ion binding]; metal-binding site 272620016195 active site 272620016196 I-site; other site 272620016197 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272620016198 active site 272620016199 catalytic residues [active] 272620016200 DNA binding site [nucleotide binding] 272620016201 Int/Topo IB signature motif; other site 272620016202 Initiator Replication protein; Region: Rep_3; pfam01051 272620016203 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 272620016204 MerR family regulatory protein; Region: MerR; pfam00376 272620016205 DNA binding residues [nucleotide binding] 272620016206 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620016207 P-loop; other site 272620016208 Magnesium ion binding site [ion binding]; other site 272620016209 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620016210 Magnesium ion binding site [ion binding]; other site 272620016211 plasmid-partitioning protein; Provisional; Region: PRK13698 272620016212 ParB-like nuclease domain; Region: ParB; smart00470 272620016213 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 272620016214 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272620016215 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272620016216 active site 272620016217 DNA binding site [nucleotide binding] 272620016218 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272620016219 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272620016220 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272620016221 Catalytic site [active] 272620016222 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 272620016223 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 272620016224 putative active site [active] 272620016225 putative NTP binding site [chemical binding]; other site 272620016226 putative nucleic acid binding site [nucleotide binding]; other site 272620016227 Antirestriction protein; Region: Antirestrict; pfam03230 272620016228 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 272620016229 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 272620016230 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620016231 S-adenosylmethionine binding site [chemical binding]; other site 272620016232 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272620016233 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272620016234 dimer interface [polypeptide binding]; other site 272620016235 ssDNA binding site [nucleotide binding]; other site 272620016236 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620016237 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 272620016238 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272620016239 ParB-like nuclease domain; Region: ParBc; pfam02195 272620016240 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 272620016241 PsiA protein; Region: PsiA; pfam06952 272620016242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 272620016243 Integrase core domain; Region: rve; pfam00665 272620016244 Integrase core domain; Region: rve_3; pfam13683 272620016245 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 272620016246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620016247 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 272620016248 salt bridge; other site 272620016249 non-specific DNA binding site [nucleotide binding]; other site 272620016250 sequence-specific DNA binding site [nucleotide binding]; other site 272620016251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 272620016252 non-specific DNA binding site [nucleotide binding]; other site 272620016253 salt bridge; other site 272620016254 sequence-specific DNA binding site [nucleotide binding]; other site 272620016255 Domain of unknown function (DUF932); Region: DUF932; pfam06067 272620016256 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272620016257 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620016258 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620016259 catalytic residue [active] 272620016260 TraM protein; Region: Tra_M; pfam05261 272620016261 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 272620016262 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 272620016263 DNA binding residues [nucleotide binding] 272620016264 conjugal transfer protein TraY; Provisional; Region: PRK13740 272620016265 TraY domain; Region: TraY; pfam05509 272620016266 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 272620016267 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 272620016268 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 272620016269 conjugal transfer protein TraK; Provisional; Region: PRK13736 272620016270 TraK protein; Region: TraK; pfam06586 272620016271 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 272620016272 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272620016273 TraP protein; Region: TraP; pfam07296 272620016274 conjugal transfer protein TraV; Provisional; Region: PRK13733 272620016275 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 272620016276 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 272620016277 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 272620016278 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 272620016279 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 272620016280 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 272620016281 conjugal transfer protein TrbE; Provisional; Region: PRK13718 272620016282 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 272620016283 F plasmid transfer operon protein; Region: TraF; pfam13728 272620016284 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 272620016285 conjugal transfer protein TrbB; Provisional; Region: PRK13728 272620016286 conjugal transfer protein TrbF; Provisional; Region: PRK13743 272620016287 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 272620016288 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 272620016289 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 272620016290 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 272620016291 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 272620016292 conjugal transfer protein TraD; Provisional; Region: PRK13700 272620016293 F sex factor protein N terminal; Region: TraD_N; pfam12615 272620016294 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 272620016295 multimer interface [polypeptide binding]; other site 272620016296 Walker A motif; other site 272620016297 ATP binding site [chemical binding]; other site 272620016298 Walker B motif; other site 272620016299 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 272620016300 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 272620016301 AAA domain; Region: AAA_30; pfam13604 272620016302 DNA helicase TraI; Region: TraI; pfam07057 272620016303 TraX protein; Region: TraX; cl05434 272620016304 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 272620016305 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 272620016306 ProQ/FINO family; Region: ProQ; pfam04352 272620016307 putative RNA binding sites [nucleotide binding]; other site 272620016308 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 272620016309 S-type Pyocin; Region: Pyocin_S; pfam06958 272620016310 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 272620016311 active site 272620016312 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 272620016313 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 272620016314 PLD-like domain; Region: PLDc_2; pfam13091 272620016315 putative active site [active] 272620016316 catalytic site [active] 272620016317 replication protein; Provisional; Region: PRK13702 272620016318 replication protein; Provisional; Region: PRK13750 272620016319 zinc finger; Region: ZnF_C2H2; smart00355 272620016320 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 272620016321 Uncharacterized conserved protein [Function unknown]; Region: COG5464 272620016322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016323 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016324 Integrase core domain; Region: rve; pfam00665 272620016325 beta-lactamase TEM; Provisional; Region: PRK15442 272620016326 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272620016327 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272620016328 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 272620016329 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272620016330 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272620016331 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 272620016332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272620016333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 272620016334 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272620016335 active site 272620016336 Zn2+ binding site [ion binding]; other site 272620016337 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 272620016338 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 272620016339 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272620016340 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272620016341 catalytic residues [active] 272620016342 catalytic nucleophile [active] 272620016343 Presynaptic Site I dimer interface [polypeptide binding]; other site 272620016344 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272620016345 Synaptic Flat tetramer interface [polypeptide binding]; other site 272620016346 Synaptic Site I dimer interface [polypeptide binding]; other site 272620016347 DNA binding site [nucleotide binding] 272620016348 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 272620016349 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 272620016350 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 272620016351 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620016352 Coenzyme A binding pocket [chemical binding]; other site 272620016353 aminoglycoside resistance protein; Provisional; Region: PRK13746 272620016354 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 272620016355 active site 272620016356 NTP binding site [chemical binding]; other site 272620016357 metal binding triad [ion binding]; metal-binding site 272620016358 antibiotic binding site [chemical binding]; other site 272620016359 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 272620016360 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272620016361 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 272620016362 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 272620016363 beta-lactamase TEM; Provisional; Region: PRK15442 272620016364 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272620016365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016366 Integrase core domain; Region: rve; pfam00665 272620016367 Integrase core domain; Region: rve; pfam00665 272620016368 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 272620016369 putative mercury resistance protein; Provisional; Region: PRK13747 272620016370 transcriptional regulator MerD; Provisional; Region: PRK13749 272620016371 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 272620016372 DNA binding residues [nucleotide binding] 272620016373 putative mercuric reductase; Provisional; Region: PRK13748 272620016374 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 272620016375 metal-binding site [ion binding] 272620016376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272620016377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272620016378 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272620016379 putative mercury transport protein MerC; Provisional; Region: PRK13755 272620016380 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 272620016381 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 272620016382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 272620016383 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 272620016384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620016385 AAA domain; Region: AAA_23; pfam13476 272620016386 Walker A/P-loop; other site 272620016387 ATP binding site [chemical binding]; other site 272620016388 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 272620016389 oligomeric interface; other site 272620016390 putative active site [active] 272620016391 homodimer interface [polypeptide binding]; other site 272620016392 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 272620016393 Phage integrase family; Region: Phage_integrase; pfam00589 272620016394 active site 272620016395 DNA binding site [nucleotide binding] 272620016396 Int/Topo IB signature motif; other site 272620016397 Flagellin N-methylase; Region: FliB; cl00497 272620016398 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 272620016399 Transposase; Region: DDE_Tnp_ISL3; pfam01610 272620016400 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 272620016401 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 272620016402 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272620016403 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272620016404 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272620016405 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272620016406 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272620016407 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272620016408 ParB-like nuclease domain; Region: ParB; smart00470 272620016409 ParB family; Region: ParB; pfam08775 272620016410 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272620016411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620016412 P-loop; other site 272620016413 Magnesium ion binding site [ion binding]; other site 272620016414 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620016415 Magnesium ion binding site [ion binding]; other site 272620016416 Initiator Replication protein; Region: Rep_3; pfam01051 272620016417 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272620016418 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272620016419 Catalytic site [active] 272620016420 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272620016421 Mg binding site [ion binding]; other site 272620016422 nucleotide binding site [chemical binding]; other site 272620016423 putative protofilament interface [polypeptide binding]; other site 272620016424 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 272620016425 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 272620016426 putative methylase; Provisional; Region: PRK13699 272620016427 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272620016428 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 272620016429 Antirestriction protein; Region: Antirestrict; pfam03230 272620016430 Antirestriction protein (ArdA); Region: ArdA; pfam07275 272620016431 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; cl11635 272620016432 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 272620016433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620016434 S-adenosylmethionine binding site [chemical binding]; other site 272620016435 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272620016436 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272620016437 dimer interface [polypeptide binding]; other site 272620016438 ssDNA binding site [nucleotide binding]; other site 272620016439 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272620016440 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 272620016441 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 272620016442 ParB-like nuclease domain; Region: ParB; smart00470 272620016443 Plasmid SOS inhibition protein (PsiB); Region: PsiB; pfam06290 272620016444 PsiA protein; Region: PsiA; pfam06952 272620016445 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272620016446 Domain of unknown function (DUF932); Region: DUF932; pfam06067 272620016447 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 272620016448 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 272620016449 N-acetyl-D-glucosamine binding site [chemical binding]; other site 272620016450 catalytic residue [active] 272620016451 TraM protein; Region: Tra_M; pfam05261 272620016452 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 272620016453 conjugal transfer protein TraY; Provisional; Region: PRK13740 272620016454 TraY domain; Region: TraY; pfam05509 272620016455 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 272620016456 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 272620016457 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 272620016458 conjugal transfer protein TraK; Provisional; Region: PRK13736 272620016459 TraK protein; Region: TraK; pfam06586 272620016460 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 272620016461 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 272620016462 conjugal transfer protein TraV; Provisional; Region: PRK13733 272620016463 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 272620016464 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 272620016465 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 272620016466 Type-F conjugative transfer system protein (TrbI_Ftype); Region: TrbI_Ftype; pfam09677 272620016467 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 272620016468 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 272620016469 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 272620016470 type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750 272620016471 conjugal transfer protein TrbE; Provisional; Region: PRK13718 272620016472 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 272620016473 F plasmid transfer operon protein; Region: TraF; pfam13728 272620016474 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 272620016475 conjugal transfer protein TrbB; Provisional; Region: PRK13728 272620016476 conjugal transfer protein TrbF; Provisional; Region: PRK13743 272620016477 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 272620016478 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 272620016479 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 272620016480 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 272620016481 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 272620016482 conjugal transfer protein TraD; Provisional; Region: PRK13700 272620016483 F sex factor protein N terminal; Region: TraD_N; pfam12615 272620016484 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 272620016485 multimer interface [polypeptide binding]; other site 272620016486 Walker A motif; other site 272620016487 ATP binding site [chemical binding]; other site 272620016488 Walker B motif; other site 272620016489 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 272620016490 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 272620016491 AAA domain; Region: AAA_30; pfam13604 272620016492 DNA helicase TraI; Region: TraI; pfam07057 272620016493 TraX protein; Region: TraX; cl05434 272620016494 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 272620016495 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 272620016496 ProQ/FINO family; Region: ProQ; pfam04352 272620016497 putative RNA binding sites [nucleotide binding]; other site 272620016498 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272620016499 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272620016500 catalytic residues [active] 272620016501 catalytic nucleophile [active] 272620016502 Presynaptic Site I dimer interface [polypeptide binding]; other site 272620016503 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272620016504 Synaptic Flat tetramer interface [polypeptide binding]; other site 272620016505 Synaptic Site I dimer interface [polypeptide binding]; other site 272620016506 DNA binding site [nucleotide binding] 272620016507 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 272620016508 DDE domain; Region: DDE_Tnp_IS240; pfam13610 272620016509 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016510 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016511 Integrase core domain; Region: rve; pfam00665 272620016512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272620016513 S-adenosylmethionine binding site [chemical binding]; other site 272620016514 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 272620016515 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 272620016516 Antirestriction protein (ArdA); Region: ArdA; pfam07275 272620016517 Antirestriction protein; Region: Antirestrict; pfam03230 272620016518 Protein of unknown function (DUF1380); Region: DUF1380; pfam07128 272620016519 putative methylase; Provisional; Region: PRK13699 272620016520 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272620016521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016522 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016523 Integrase core domain; Region: rve; pfam00665 272620016524 multiple promoter invertase; Provisional; Region: mpi; PRK13413 272620016525 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 272620016526 catalytic residues [active] 272620016527 catalytic nucleophile [active] 272620016528 Presynaptic Site I dimer interface [polypeptide binding]; other site 272620016529 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 272620016530 Synaptic Flat tetramer interface [polypeptide binding]; other site 272620016531 Synaptic Site I dimer interface [polypeptide binding]; other site 272620016532 DNA binding site [nucleotide binding] 272620016533 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 272620016534 DNA-binding interface [nucleotide binding]; DNA binding site 272620016535 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 272620016536 Phosphotransferase enzyme family; Region: APH; pfam01636 272620016537 active site 272620016538 ATP binding site [chemical binding]; other site 272620016539 antibiotic binding site [chemical binding]; other site 272620016540 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 272620016541 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 272620016542 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 272620016543 Transposase; Region: DEDD_Tnp_IS110; pfam01548 272620016544 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 272620016545 dihydropteroate synthase; Region: DHPS; TIGR01496 272620016546 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272620016547 substrate binding pocket [chemical binding]; other site 272620016548 dimer interface [polypeptide binding]; other site 272620016549 inhibitor binding site; inhibition site 272620016550 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 272620016551 Putative transposase; Region: Y2_Tnp; pfam04986 272620016552 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 272620016553 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 272620016554 catalytic residues [active] 272620016555 catalytic nucleophile [active] 272620016556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016557 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016558 Integrase core domain; Region: rve; pfam00665 272620016559 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 272620016560 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 272620016561 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 272620016562 substrate binding pocket [chemical binding]; other site 272620016563 membrane-bound complex binding site; other site 272620016564 hinge residues; other site 272620016565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272620016566 dimer interface [polypeptide binding]; other site 272620016567 conserved gate region; other site 272620016568 putative PBP binding loops; other site 272620016569 ABC-ATPase subunit interface; other site 272620016570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272620016571 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 272620016572 Phosphotransferase enzyme family; Region: APH; pfam01636 272620016573 active site 272620016574 ATP binding site [chemical binding]; other site 272620016575 antibiotic binding site [chemical binding]; other site 272620016576 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016577 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016578 Integrase core domain; Region: rve; pfam00665 272620016579 Initiator Replication protein; Region: Rep_3; pfam01051 272620016580 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272620016581 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272620016582 folate binding site [chemical binding]; other site 272620016583 NADP+ binding site [chemical binding]; other site 272620016584 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 272620016585 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 272620016586 Putative transposase; Region: Y2_Tnp; pfam04986 272620016587 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 272620016588 dihydropteroate synthase; Region: DHPS; TIGR01496 272620016589 substrate binding pocket [chemical binding]; other site 272620016590 dimer interface [polypeptide binding]; other site 272620016591 inhibitor binding site; inhibition site 272620016592 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 272620016593 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 272620016594 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620016595 putative substrate translocation pore; other site 272620016596 YCII-related domain; Region: YCII; cl00999 272620016597 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 272620016598 integrase/recombinase; Provisional; Region: PRK15417 272620016599 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 272620016600 Int/Topo IB signature motif; other site 272620016601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016602 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016603 Integrase core domain; Region: rve; pfam00665 272620016604 helicase-primase primase subunit; Provisional; Region: PHA03119 272620016605 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 272620016606 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 272620016607 bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Provisional; Region: PRK13982 272620016608 Phage integrase family; Region: Phage_integrase; pfam00589 272620016609 active site 272620016610 DNA binding site [nucleotide binding] 272620016611 Int/Topo IB signature motif; other site 272620016612 Initiator Replication protein; Region: Rep_3; pfam01051 272620016613 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272620016614 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620016615 P-loop; other site 272620016616 Magnesium ion binding site [ion binding]; other site 272620016617 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272620016618 Magnesium ion binding site [ion binding]; other site 272620016619 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 272620016620 ParB-like nuclease domain; Region: ParBc; pfam02195 272620016621 ParB family; Region: ParB; pfam08775 272620016622 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 272620016623 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 272620016624 active site 272620016625 DNA binding site [nucleotide binding] 272620016626 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 272620016627 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 272620016628 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 272620016629 Catalytic site [active] 272620016630 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 272620016631 Mg binding site [ion binding]; other site 272620016632 nucleotide binding site [chemical binding]; other site 272620016633 putative protofilament interface [polypeptide binding]; other site 272620016634 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 272620016635 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 272620016636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016637 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016638 Integrase core domain; Region: rve; pfam00665 272620016639 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272620016640 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 272620016641 putative metal binding site [ion binding]; other site 272620016642 putative homodimer interface [polypeptide binding]; other site 272620016643 putative homotetramer interface [polypeptide binding]; other site 272620016644 putative homodimer-homodimer interface [polypeptide binding]; other site 272620016645 putative allosteric switch controlling residues; other site 272620016646 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272620016647 chloramphenicol acetyltransferase; Provisional; Region: PRK13757 272620016648 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 272620016649 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016650 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016651 Integrase core domain; Region: rve; pfam00665 272620016652 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 272620016653 Protein of unknown function (DUF2913); Region: DUF2913; pfam11140 272620016654 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016655 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016656 Integrase core domain; Region: rve; pfam00665 272620016657 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 272620016658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 272620016659 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016660 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 272620016661 Chlorite dismutase; Region: Chlor_dismutase; cl01280 272620016662 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272620016663 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272620016664 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 272620016665 Catalytic site; other site 272620016666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016667 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016668 Integrase core domain; Region: rve; pfam00665 272620016669 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 272620016670 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 272620016671 Sulfate transporter family; Region: Sulfate_transp; pfam00916 272620016672 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 272620016673 Universal stress protein family; Region: Usp; pfam00582 272620016674 Ligand Binding Site [chemical binding]; other site 272620016675 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 272620016676 Ligand Binding Site [chemical binding]; other site 272620016677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620016678 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620016679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620016680 chromosome condensation membrane protein; Provisional; Region: PRK14196 272620016681 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 272620016682 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 272620016683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 272620016684 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 272620016685 Integrase core domain; Region: rve; pfam00665 272620016686 tetracycline repressor protein TetR; Provisional; Region: PRK13756 272620016687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272620016688 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 272620016689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272620016690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272620016691 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 272620016692 beta-lactamase TEM; Provisional; Region: PRK15442 272620016693 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 272620016694 Rop protein; Region: Rop; pfam01815 272620016695 Helix-turn-helix domain; Region: HTH_17; pfam12728 272620016696 AAA domain; Region: AAA_21; pfam13304 272620016697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272620016698 Walker B; other site 272620016699 D-loop; other site 272620016700 H-loop/switch region; other site 272620016701 Helix-turn-helix domain; Region: HTH_36; pfam13730 272620016702 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 272620016703 PemK-like protein; Region: PemK; cl00995 272620016704 Rop protein; Region: Rop; pfam01815 272620016705 Helix-turn-helix domain; Region: HTH_17; pfam12728