-- dump date 20140619_121604 -- class Genbank::misc_feature -- table misc_feature_note -- id note 484021000001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021000002 S-adenosylmethionine binding site [chemical binding]; other site 484021000003 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 484021000004 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021000005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021000006 ABC-ATPase subunit interface; other site 484021000007 dimer interface [polypeptide binding]; other site 484021000008 putative PBP binding regions; other site 484021000009 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 484021000010 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 484021000011 putative ligand binding residues [chemical binding]; other site 484021000012 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 484021000013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021000014 Walker A/P-loop; other site 484021000015 ATP binding site [chemical binding]; other site 484021000016 Q-loop/lid; other site 484021000017 ABC transporter signature motif; other site 484021000018 Walker B; other site 484021000019 D-loop; other site 484021000020 H-loop/switch region; other site 484021000021 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021000022 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021000023 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cl08497 484021000024 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 484021000025 BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; Region: BAH; cl02608 484021000026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 484021000027 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 484021000028 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 484021000029 Integrase core domain; Region: rve; pfam00665 484021000030 Methyltransferase domain; Region: Methyltransf_23; pfam13489 484021000031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021000032 S-adenosylmethionine binding site [chemical binding]; other site 484021000033 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021000034 DNA binding residues [nucleotide binding] 484021000035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021000036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021000037 DNA binding residues [nucleotide binding] 484021000038 dimerization interface [polypeptide binding]; other site 484021000039 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021000040 EamA-like transporter family; Region: EamA; pfam00892 484021000041 EamA-like transporter family; Region: EamA; pfam00892 484021000042 outer membrane receptor FepA; Provisional; Region: PRK13528 484021000043 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021000044 N-terminal plug; other site 484021000045 ligand-binding site [chemical binding]; other site 484021000046 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 484021000047 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 484021000048 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 484021000049 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021000050 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484021000051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021000052 Walker A/P-loop; other site 484021000053 ATP binding site [chemical binding]; other site 484021000054 Q-loop/lid; other site 484021000055 ABC transporter signature motif; other site 484021000056 Walker B; other site 484021000057 D-loop; other site 484021000058 H-loop/switch region; other site 484021000059 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484021000060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021000061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021000062 Walker A/P-loop; other site 484021000063 ATP binding site [chemical binding]; other site 484021000064 Q-loop/lid; other site 484021000065 ABC transporter signature motif; other site 484021000066 Walker B; other site 484021000067 D-loop; other site 484021000068 H-loop/switch region; other site 484021000069 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 484021000070 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 484021000071 homodimer interface [polypeptide binding]; other site 484021000072 active site 484021000073 TDP-binding site; other site 484021000074 acceptor substrate-binding pocket; other site 484021000075 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 484021000076 ParB-like nuclease domain; Region: ParB; smart00470 484021000077 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 484021000078 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 484021000079 Active Sites [active] 484021000080 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 484021000081 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 484021000082 Integrase core domain; Region: rve_2; pfam13333 484021000083 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 484021000084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484021000085 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 484021000087 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 484021000088 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021000089 N-terminal plug; other site 484021000090 ligand-binding site [chemical binding]; other site 484021000091 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 484021000092 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 484021000093 Y-family of DNA polymerases; Region: PolY; cl12025 484021000094 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 484021000095 Protein of unknown function (DUF2384); Region: DUF2384; cl17718 484021000096 putative toxin-antitoxin system antitoxin component, TIGR02293 family; Region: TAS_TIGR02293 484021000097 RES domain; Region: RES; pfam08808 484021000098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 484021000099 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 484021000100 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 484021000101 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 484021000102 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 484021000103 Staphylococcal nuclease homologues; Region: SNc; smart00318 484021000104 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 484021000105 Catalytic site; other site 484021000106 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 484021000107 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 484021000108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021000109 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021000110 active site 484021000111 catalytic tetrad [active] 484021000112 Uncharacterized conserved protein [Function unknown]; Region: COG4925 484021000113 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 484021000114 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021000115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 484021000116 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484021000117 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 484021000118 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 484021000119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021000120 putative substrate translocation pore; other site 484021000121 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484021000122 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021000123 Walker A/P-loop; other site 484021000124 ATP binding site [chemical binding]; other site 484021000125 Q-loop/lid; other site 484021000126 ABC transporter signature motif; other site 484021000127 Walker B; other site 484021000128 D-loop; other site 484021000129 H-loop/switch region; other site 484021000130 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484021000131 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021000132 Walker A/P-loop; other site 484021000133 ATP binding site [chemical binding]; other site 484021000134 Q-loop/lid; other site 484021000135 ABC transporter signature motif; other site 484021000136 Walker B; other site 484021000137 D-loop; other site 484021000138 H-loop/switch region; other site 484021000139 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021000140 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 484021000141 metal binding site [ion binding]; metal-binding site 484021000143 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 484021000144 metal binding site 2 [ion binding]; metal-binding site 484021000145 putative DNA binding helix; other site 484021000146 metal binding site 1 [ion binding]; metal-binding site 484021000147 dimer interface [polypeptide binding]; other site 484021000148 structural Zn2+ binding site [ion binding]; other site 484021000149 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 484021000150 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 484021000151 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 484021000152 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 484021000153 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 484021000154 G1 box; other site 484021000155 GTP/Mg2+ binding site [chemical binding]; other site 484021000156 ferrous iron transporter FeoB; Region: feoB; TIGR00437 484021000157 G2 box; other site 484021000158 Switch I region; other site 484021000159 G3 box; other site 484021000160 Switch II region; other site 484021000161 G4 box; other site 484021000162 G5 box; other site 484021000163 Nucleoside recognition; Region: Gate; pfam07670 484021000164 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 484021000165 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 484021000166 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484021000167 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 484021000168 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484021000169 active site 484021000170 HIGH motif; other site 484021000171 nucleotide binding site [chemical binding]; other site 484021000172 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484021000173 KMSKS motif; other site 484021000174 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484021000175 tRNA binding surface [nucleotide binding]; other site 484021000176 anticodon binding site; other site 484021000177 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 484021000178 metal binding site 2 [ion binding]; metal-binding site 484021000179 putative DNA binding helix; other site 484021000180 metal binding site 1 [ion binding]; metal-binding site 484021000181 dimer interface [polypeptide binding]; other site 484021000182 structural Zn2+ binding site [ion binding]; other site 484021000183 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 484021000184 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021000185 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 484021000186 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 484021000187 putative GTP cyclohydrolase; Provisional; Region: PRK13674 484021000188 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 484021000189 Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710 484021000190 trimer interface [polypeptide binding]; other site 484021000191 active site 484021000192 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 484021000193 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 484021000194 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 484021000195 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484021000196 active site 484021000197 motif 3; other site 484021000198 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 484021000199 anticodon binding site; other site 484021000200 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 484021000201 putative active site [active] 484021000202 Zn binding site [ion binding]; other site 484021000203 dihydroorotase; Reviewed; Region: PRK09236 484021000204 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484021000205 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 484021000206 active site 484021000207 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 484021000208 dimer interface [polypeptide binding]; other site 484021000209 allosteric magnesium binding site [ion binding]; other site 484021000210 active site 484021000211 aspartate-rich active site metal binding site; other site 484021000212 Schiff base residues; other site 484021000213 Integrase core domain; Region: rve; pfam00665 484021000214 Integrase core domain; Region: rve_2; pfam13333 484021000215 Integrase core domain; Region: rve_3; pfam13683 484021000216 HTH-like domain; Region: HTH_21; pfam13276 484021000217 Integrase core domain; Region: rve; pfam00665 484021000218 IS2 repressor TnpA; Reviewed; Region: PRK09413 484021000219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021000220 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484021000221 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 484021000222 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 484021000223 catalytic residues [active] 484021000224 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 484021000225 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 484021000226 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 484021000227 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 484021000228 Integrase core domain; Region: rve; pfam00665 484021000229 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 484021000230 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021000231 non-specific DNA binding site [nucleotide binding]; other site 484021000232 salt bridge; other site 484021000233 sequence-specific DNA binding site [nucleotide binding]; other site 484021000234 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021000235 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021000236 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 484021000237 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 484021000238 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 484021000239 multiple promoter invertase; Provisional; Region: mpi; PRK13413 484021000240 catalytic residues [active] 484021000241 catalytic nucleophile [active] 484021000242 Presynaptic Site I dimer interface [polypeptide binding]; other site 484021000243 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 484021000244 Synaptic Flat tetramer interface [polypeptide binding]; other site 484021000245 Synaptic Site I dimer interface [polypeptide binding]; other site 484021000246 DNA binding site [nucleotide binding] 484021000247 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 484021000248 DNA-binding interface [nucleotide binding]; DNA binding site 484021000249 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 484021000250 active site 484021000251 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 484021000252 lipoprotein signal peptidase; Provisional; Region: PRK14787 484021000253 Heavy-metal-associated domain; Region: HMA; pfam00403 484021000254 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 484021000255 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 484021000256 metal-binding site [ion binding] 484021000257 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021000258 Soluble P-type ATPase [General function prediction only]; Region: COG4087 484021000259 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 484021000260 Helix-Turn-Helix DNA binding domain of the CadR and PbrR transcription regulators; Region: HTH_CadR-PbrR; cd04784 484021000261 DNA binding residues [nucleotide binding] 484021000262 dimer interface [polypeptide binding]; other site 484021000263 putative metal binding site [ion binding]; other site 484021000264 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 484021000265 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021000266 dimerization interface [polypeptide binding]; other site 484021000267 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021000268 dimer interface [polypeptide binding]; other site 484021000269 phosphorylation site [posttranslational modification] 484021000270 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021000271 ATP binding site [chemical binding]; other site 484021000272 Mg2+ binding site [ion binding]; other site 484021000273 G-X-G motif; other site 484021000274 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 484021000275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021000276 active site 484021000277 phosphorylation site [posttranslational modification] 484021000278 intermolecular recognition site; other site 484021000279 dimerization interface [polypeptide binding]; other site 484021000280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021000281 DNA binding site [nucleotide binding] 484021000282 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 484021000283 CopC domain; Region: CopC; pfam04234 484021000284 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 484021000285 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 484021000286 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 484021000287 Multicopper oxidase; Region: Cu-oxidase; pfam00394 484021000288 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 484021000289 Peptidase family M23; Region: Peptidase_M23; pfam01551 484021000290 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 484021000291 YHS domain; Region: YHS; pfam04945 484021000292 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 484021000293 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021000294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021000295 motif II; other site 484021000296 Protein of unknown function, DUF; Region: DUF411; cl01142 484021000297 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 484021000298 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 484021000299 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021000300 periplasmic copper-binding protein; Provisional; Region: PRK09838 484021000301 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 484021000302 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 484021000303 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021000304 active site 484021000305 phosphorylation site [posttranslational modification] 484021000306 intermolecular recognition site; other site 484021000307 dimerization interface [polypeptide binding]; other site 484021000308 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021000309 DNA binding site [nucleotide binding] 484021000310 sensor kinase CusS; Provisional; Region: PRK09835 484021000311 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021000312 dimerization interface [polypeptide binding]; other site 484021000313 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021000314 dimer interface [polypeptide binding]; other site 484021000315 phosphorylation site [posttranslational modification] 484021000316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021000317 ATP binding site [chemical binding]; other site 484021000318 Mg2+ binding site [ion binding]; other site 484021000319 G-X-G motif; other site 484021000320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 484021000321 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3183 484021000322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 484021000323 active site 484021000324 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 484021000325 GAF domain; Region: GAF; pfam01590 484021000326 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021000327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021000328 metal binding site [ion binding]; metal-binding site 484021000329 active site 484021000330 I-site; other site 484021000331 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 484021000332 active site 484021000333 catalytic residues [active] 484021000334 DNA binding site [nucleotide binding] 484021000335 Int/Topo IB signature motif; other site 484021000336 Uncharacterized conserved protein [Function unknown]; Region: COG5464 484021000337 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021000338 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 484021000339 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 484021000340 Zn binding sites [ion binding]; other site 484021000341 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 484021000342 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021000343 P-loop; other site 484021000344 Magnesium ion binding site [ion binding]; other site 484021000345 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021000346 Magnesium ion binding site [ion binding]; other site 484021000347 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 484021000348 KorB domain; Region: KorB; pfam08535 484021000349 Transposase; Region: HTH_Tnp_1; pfam01527 484021000350 HTH-like domain; Region: HTH_21; pfam13276 484021000351 transposase/IS protein; Provisional; Region: PRK09183 484021000352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021000353 Walker A motif; other site 484021000354 ATP binding site [chemical binding]; other site 484021000355 Walker B motif; other site 484021000356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 484021000357 Integrase core domain; Region: rve; pfam00665 484021000358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 484021000359 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 484021000360 KorB domain; Region: KorB; pfam08535 484021000361 DNA-binding interface [nucleotide binding]; DNA binding site 484021000362 Transposase; Region: HTH_Tnp_1; cl17663 484021000363 putative transposase OrfB; Reviewed; Region: PHA02517 484021000364 HTH-like domain; Region: HTH_21; pfam13276 484021000365 Integrase core domain; Region: rve; pfam00665 484021000366 Integrase core domain; Region: rve_3; pfam13683 484021000367 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 484021000369 Initiator Replication protein; Region: Rep_3; pfam01051 484021000370 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 484021000371 MerR family regulatory protein; Region: MerR; pfam00376 484021000372 DNA binding residues [nucleotide binding] 484021000373 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021000374 P-loop; other site 484021000375 Magnesium ion binding site [ion binding]; other site 484021000376 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021000377 Magnesium ion binding site [ion binding]; other site 484021000378 plasmid-partitioning protein; Provisional; Region: PRK13698 484021000379 ParB-like nuclease domain; Region: ParB; smart00470 484021000380 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 484021000381 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 484021000382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021000383 Transposase; Region: HTH_Tnp_1; pfam01527 484021000384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 484021000385 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 484021000386 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 484021000387 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 484021000388 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 484021000389 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 484021000390 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 484021000391 Transposase; Region: HTH_Tnp_1; cl17663 484021000392 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021000393 Transposase; Region: DEDD_Tnp_IS110; pfam01548 484021000394 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 484021000395 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 484021000396 Transposase; Region: HTH_Tnp_1; cl17663 484021000397 IS2 transposase TnpB; Reviewed; Region: PRK09409 484021000398 HTH-like domain; Region: HTH_21; pfam13276 484021000399 Integrase core domain; Region: rve; pfam00665 484021000400 Integrase core domain; Region: rve_3; pfam13683 484021000401 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 484021000402 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 484021000403 DNA binding site [nucleotide binding] 484021000404 dimer interface [polypeptide binding]; other site 484021000405 active site 484021000406 Int/Topo IB signature motif; other site 484021000407 Haemolysin expression modulating protein; Region: HHA; cl11501 484021000409 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 484021000410 Initiator Replication protein; Region: Rep_3; cl03080 484021000411 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021000412 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021000413 DNA-binding site [nucleotide binding]; DNA binding site 484021000414 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021000415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021000416 homodimer interface [polypeptide binding]; other site 484021000417 catalytic residue [active] 484021000418 MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044 484021000419 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 484021000420 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484021000421 putative active site [active] 484021000422 catalytic triad [active] 484021000423 putative dimer interface [polypeptide binding]; other site 484021000424 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 484021000425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021000426 FeS/SAM binding site; other site 484021000427 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021000428 Coenzyme A binding pocket [chemical binding]; other site 484021000429 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 484021000430 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 484021000431 dimerization interface [polypeptide binding]; other site 484021000432 putative ATP binding site [chemical binding]; other site 484021000433 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 484021000434 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 484021000435 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021000436 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484021000437 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 484021000438 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484021000439 acyl-activating enzyme (AAE) consensus motif; other site 484021000440 AMP binding site [chemical binding]; other site 484021000441 active site 484021000442 CoA binding site [chemical binding]; other site 484021000443 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021000444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 484021000445 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; pfam10008 484021000446 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 484021000447 substrate binding site [chemical binding]; other site 484021000448 activation loop (A-loop); other site 484021000449 Protein phosphatase 2C; Region: PP2C_2; pfam13672 484021000450 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 484021000451 metal ion-dependent adhesion site (MIDAS); other site 484021000452 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 484021000453 metal ion-dependent adhesion site (MIDAS); other site 484021000454 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 484021000455 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000456 putative metal binding site [ion binding]; other site 484021000457 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 484021000458 metal ion-dependent adhesion site (MIDAS); other site 484021000459 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 484021000460 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 484021000461 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 484021000462 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 484021000463 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 484021000464 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 484021000465 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 484021000466 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 484021000467 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000468 putative metal binding site [ion binding]; other site 484021000469 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 484021000470 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000471 putative metal binding site [ion binding]; other site 484021000472 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 484021000473 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000474 putative metal binding site [ion binding]; other site 484021000475 tellurite resistance protein terB; Region: terB; cd07176 484021000476 putative metal binding site [ion binding]; other site 484021000477 Integral membrane protein TerC family; Region: TerC; cl10468 484021000478 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 484021000479 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000480 putative metal binding site [ion binding]; other site 484021000481 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 484021000482 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000483 putative metal binding site [ion binding]; other site 484021000484 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 484021000485 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 484021000486 putative metal binding site [ion binding]; other site 484021000487 Bacterial stress protein; Region: TerD; pfam02342 484021000488 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 484021000489 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484021000490 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021000491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021000492 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 484021000493 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 484021000494 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 484021000495 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 484021000496 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 484021000497 catalytic residues [active] 484021000498 catalytic nucleophile [active] 484021000499 Presynaptic Site I dimer interface [polypeptide binding]; other site 484021000500 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 484021000501 Synaptic Flat tetramer interface [polypeptide binding]; other site 484021000502 Synaptic Site I dimer interface [polypeptide binding]; other site 484021000503 DNA binding site [nucleotide binding] 484021000504 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 484021000505 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 484021000506 Cupin; Region: Cupin_6; pfam12852 484021000507 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 484021000508 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 484021000509 putative NAD(P) binding site [chemical binding]; other site 484021000510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 484021000511 Transposase; Region: DEDD_Tnp_IS110; pfam01548 484021000512 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 484021000513 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021000514 EamA-like transporter family; Region: EamA; pfam00892 484021000515 EamA-like transporter family; Region: EamA; pfam00892 484021000516 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 484021000517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021000518 putative DNA binding site [nucleotide binding]; other site 484021000519 putative Zn2+ binding site [ion binding]; other site 484021000520 AsnC family; Region: AsnC_trans_reg; pfam01037 484021000521 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 484021000522 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 484021000523 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; pfam10137 484021000524 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 484021000525 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 484021000526 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 484021000527 oligomeric interface; other site 484021000528 putative active site [active] 484021000529 homodimer interface [polypeptide binding]; other site 484021000530 Transposase; Region: HTH_Tnp_1; cl17663 484021000531 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021000532 Restriction endonuclease; Region: Mrr_cat; pfam04471 484021000533 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 484021000534 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021000535 Electron transfer DM13; Region: DM13; pfam10517 484021000536 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 484021000537 Protein of unknown function, DUF417; Region: DUF417; cl01162 484021000538 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021000539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021000540 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021000541 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 484021000542 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021000543 N-terminal plug; other site 484021000544 ligand-binding site [chemical binding]; other site 484021000545 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 484021000546 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021000547 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 484021000548 IucA / IucC family; Region: IucA_IucC; pfam04183 484021000549 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484021000550 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 484021000551 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 484021000552 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 484021000553 IucA / IucC family; Region: IucA_IucC; pfam04183 484021000554 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484021000555 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021000556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 484021000557 DDE superfamily endonuclease; Region: DDE_3; pfam13358 484021000558 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484021000559 active site 484021000560 catalytic residues [active] 484021000561 metal binding site [ion binding]; metal-binding site 484021000562 fec operon regulator FecR; Reviewed; Region: PRK09774 484021000563 lysozyme inhibitor; Provisional; Region: PRK13791 484021000564 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 484021000565 putative DNA binding helix; other site 484021000566 metal binding site 2 [ion binding]; metal-binding site 484021000567 metal binding site 1 [ion binding]; metal-binding site 484021000568 structural Zn2+ binding site [ion binding]; other site 484021000569 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 484021000570 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021000571 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 484021000572 FMN-binding protein MioC; Provisional; Region: PRK09004 484021000573 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 484021000574 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021000575 putative DNA binding site [nucleotide binding]; other site 484021000576 putative Zn2+ binding site [ion binding]; other site 484021000577 AsnC family; Region: AsnC_trans_reg; pfam01037 484021000578 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 484021000579 dimer interface [polypeptide binding]; other site 484021000580 active site 484021000581 hypothetical protein; Provisional; Region: yieM; PRK10997 484021000582 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 484021000583 metal ion-dependent adhesion site (MIDAS); other site 484021000584 regulatory ATPase RavA; Provisional; Region: PRK13531 484021000585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021000586 Walker A motif; other site 484021000587 ATP binding site [chemical binding]; other site 484021000588 Walker B motif; other site 484021000589 arginine finger; other site 484021000590 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 484021000591 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 484021000592 potassium uptake protein; Region: kup; TIGR00794 484021000593 D-ribose pyranase; Provisional; Region: PRK11797 484021000594 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 484021000595 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021000596 Walker A/P-loop; other site 484021000597 ATP binding site [chemical binding]; other site 484021000598 Q-loop/lid; other site 484021000599 ABC transporter signature motif; other site 484021000600 Walker B; other site 484021000601 D-loop; other site 484021000602 H-loop/switch region; other site 484021000603 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021000604 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021000605 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021000606 TM-ABC transporter signature motif; other site 484021000607 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 484021000608 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 484021000609 ligand binding site [chemical binding]; other site 484021000610 dimerization interface [polypeptide binding]; other site 484021000611 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021000612 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 484021000613 substrate binding site [chemical binding]; other site 484021000614 dimer interface [polypeptide binding]; other site 484021000615 ATP binding site [chemical binding]; other site 484021000616 transcriptional repressor RbsR; Provisional; Region: PRK10423 484021000617 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021000618 DNA binding site [nucleotide binding] 484021000619 domain linker motif; other site 484021000620 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 484021000621 dimerization interface [polypeptide binding]; other site 484021000622 ligand binding site [chemical binding]; other site 484021000623 putative transporter; Provisional; Region: PRK10504 484021000624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021000625 putative substrate translocation pore; other site 484021000626 Transcriptional regulators [Transcription]; Region: GntR; COG1802 484021000627 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021000628 DNA-binding site [nucleotide binding]; DNA binding site 484021000629 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 484021000630 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 484021000631 Walker A motif; other site 484021000632 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 484021000633 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 484021000634 GTP binding site; other site 484021000635 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 484021000636 serine/threonine protein kinase; Provisional; Region: PRK11768 484021000637 serine/threonine protein kinase; Provisional; Region: PRK11768 484021000638 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 484021000639 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 484021000640 catalytic residues [active] 484021000641 hinge region; other site 484021000642 alpha helical domain; other site 484021000643 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484021000644 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 484021000645 putative acyl-acceptor binding pocket; other site 484021000646 DNA polymerase I; Provisional; Region: PRK05755 484021000647 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 484021000648 active site 484021000649 metal binding site 1 [ion binding]; metal-binding site 484021000650 putative 5' ssDNA interaction site; other site 484021000651 metal binding site 3; metal-binding site 484021000652 metal binding site 2 [ion binding]; metal-binding site 484021000653 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 484021000654 putative DNA binding site [nucleotide binding]; other site 484021000655 putative metal binding site [ion binding]; other site 484021000656 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 484021000657 active site 484021000658 catalytic site [active] 484021000659 substrate binding site [chemical binding]; other site 484021000660 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 484021000661 active site 484021000662 DNA binding site [nucleotide binding] 484021000663 catalytic site [active] 484021000664 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 484021000665 G1 box; other site 484021000666 GTP/Mg2+ binding site [chemical binding]; other site 484021000667 Switch I region; other site 484021000668 G2 box; other site 484021000669 G3 box; other site 484021000670 Switch II region; other site 484021000671 G4 box; other site 484021000672 G5 box; other site 484021000673 Der GTPase activator; Provisional; Region: PRK05244 484021000674 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 484021000675 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021000676 FeS/SAM binding site; other site 484021000677 HemN C-terminal domain; Region: HemN_C; pfam06969 484021000678 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 484021000679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021000680 active site 484021000681 phosphorylation site [posttranslational modification] 484021000682 intermolecular recognition site; other site 484021000683 dimerization interface [polypeptide binding]; other site 484021000684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021000685 Walker A motif; other site 484021000686 ATP binding site [chemical binding]; other site 484021000687 Walker B motif; other site 484021000688 arginine finger; other site 484021000689 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021000690 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 484021000691 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 484021000692 putative active site [active] 484021000693 heme pocket [chemical binding]; other site 484021000694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021000695 dimer interface [polypeptide binding]; other site 484021000696 phosphorylation site [posttranslational modification] 484021000697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021000698 ATP binding site [chemical binding]; other site 484021000699 Mg2+ binding site [ion binding]; other site 484021000700 G-X-G motif; other site 484021000701 glutamine synthetase; Provisional; Region: glnA; PRK09469 484021000702 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 484021000703 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 484021000704 GTP-binding protein; Provisional; Region: PRK10218 484021000705 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 484021000706 G1 box; other site 484021000707 putative GEF interaction site [polypeptide binding]; other site 484021000708 GTP/Mg2+ binding site [chemical binding]; other site 484021000709 Switch I region; other site 484021000710 G2 box; other site 484021000711 G3 box; other site 484021000712 Switch II region; other site 484021000713 G4 box; other site 484021000714 G5 box; other site 484021000715 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 484021000716 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 484021000717 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 484021000718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021000719 motif II; other site 484021000720 hypothetical protein; Reviewed; Region: PRK01637 484021000721 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 484021000722 putative active site [active] 484021000723 dimerization interface [polypeptide binding]; other site 484021000724 putative tRNAtyr binding site [nucleotide binding]; other site 484021000725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021000726 Coenzyme A binding pocket [chemical binding]; other site 484021000727 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 484021000728 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 484021000729 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484021000730 substrate binding pocket [chemical binding]; other site 484021000731 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 484021000732 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 484021000733 oligomeric interface; other site 484021000734 putative active site [active] 484021000735 homodimer interface [polypeptide binding]; other site 484021000736 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 484021000737 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 484021000738 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 484021000739 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 484021000740 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 484021000741 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 484021000742 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 484021000743 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 484021000744 [4Fe-4S] binding site [ion binding]; other site 484021000745 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021000746 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 484021000747 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 484021000748 molybdopterin cofactor binding site; other site 484021000749 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 484021000750 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 484021000751 dimerization interface [polypeptide binding]; other site 484021000752 allosteric effector site; other site 484021000753 active site 484021000754 ADP/pyrophosphate binding site [chemical binding]; other site 484021000755 fructose-1,6-bisphosphate binding site; other site 484021000756 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 484021000757 active site 484021000758 P-loop; other site 484021000759 phosphorylation site [posttranslational modification] 484021000760 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 484021000761 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 484021000762 intersubunit interface [polypeptide binding]; other site 484021000763 active site 484021000764 zinc binding site [ion binding]; other site 484021000765 Na+ binding site [ion binding]; other site 484021000766 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021000767 active site 484021000768 phosphorylation site [posttranslational modification] 484021000769 AAA domain; Region: AAA_18; pfam13238 484021000770 AAA domain; Region: AAA_17; pfam13207 484021000771 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 484021000772 AzlC protein; Region: AzlC; cl00570 484021000773 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021000774 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021000775 non-specific DNA binding site [nucleotide binding]; other site 484021000776 salt bridge; other site 484021000777 sequence-specific DNA binding site [nucleotide binding]; other site 484021000778 Cupin domain; Region: Cupin_2; cl17218 484021000779 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021000780 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021000781 DNA binding site [nucleotide binding] 484021000782 domain linker motif; other site 484021000783 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 484021000784 ligand binding site [chemical binding]; other site 484021000785 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 484021000786 Melibiase; Region: Melibiase; pfam02065 484021000787 galactoside permease; Reviewed; Region: lacY; PRK09528 484021000788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021000789 putative substrate translocation pore; other site 484021000790 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 484021000791 lactaldehyde reductase; Region: lactal_redase; TIGR02638 484021000792 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 484021000793 dimer interface [polypeptide binding]; other site 484021000794 active site 484021000795 metal binding site [ion binding]; metal-binding site 484021000796 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021000797 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021000798 TM-ABC transporter signature motif; other site 484021000799 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021000800 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021000801 TM-ABC transporter signature motif; other site 484021000802 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021000803 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021000804 Walker A/P-loop; other site 484021000805 ATP binding site [chemical binding]; other site 484021000806 Q-loop/lid; other site 484021000807 ABC transporter signature motif; other site 484021000808 Walker B; other site 484021000809 D-loop; other site 484021000810 H-loop/switch region; other site 484021000811 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021000812 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 484021000813 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 484021000814 ligand binding site [chemical binding]; other site 484021000815 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 484021000816 intersubunit interface [polypeptide binding]; other site 484021000817 active site 484021000818 Zn2+ binding site [ion binding]; other site 484021000819 L-rhamnose isomerase; Provisional; Region: PRK01076 484021000820 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 484021000821 N- and C-terminal domain interface [polypeptide binding]; other site 484021000822 active site 484021000823 putative catalytic site [active] 484021000824 metal binding site [ion binding]; metal-binding site 484021000825 ATP binding site [chemical binding]; other site 484021000826 rhamnulokinase; Provisional; Region: rhaB; PRK10640 484021000827 carbohydrate binding site [chemical binding]; other site 484021000828 transcriptional activator RhaS; Provisional; Region: PRK13503 484021000829 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021000830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021000831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021000832 transcriptional activator RhaR; Provisional; Region: PRK13502 484021000833 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021000834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021000835 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 484021000836 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 484021000837 superoxide dismutase; Provisional; Region: PRK10925 484021000838 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 484021000839 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 484021000840 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 484021000841 MOSC domain; Region: MOSC; pfam03473 484021000842 3-alpha domain; Region: 3-alpha; pfam03475 484021000843 two-component sensor protein; Provisional; Region: cpxA; PRK09470 484021000844 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021000845 dimerization interface [polypeptide binding]; other site 484021000846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021000847 dimer interface [polypeptide binding]; other site 484021000848 phosphorylation site [posttranslational modification] 484021000849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021000850 ATP binding site [chemical binding]; other site 484021000851 Mg2+ binding site [ion binding]; other site 484021000852 G-X-G motif; other site 484021000853 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 484021000854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021000855 active site 484021000856 phosphorylation site [posttranslational modification] 484021000857 intermolecular recognition site; other site 484021000858 dimerization interface [polypeptide binding]; other site 484021000859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021000860 DNA binding site [nucleotide binding] 484021000861 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 484021000862 dimer interface [polypeptide binding]; other site 484021000863 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 484021000864 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 484021000865 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 484021000866 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 484021000867 active site 484021000868 ADP/pyrophosphate binding site [chemical binding]; other site 484021000869 dimerization interface [polypeptide binding]; other site 484021000870 allosteric effector site; other site 484021000871 fructose-1,6-bisphosphate binding site; other site 484021000872 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 484021000873 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 484021000874 UbiA prenyltransferase family; Region: UbiA; pfam01040 484021000875 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 484021000876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021000877 Walker A motif; other site 484021000878 ATP binding site [chemical binding]; other site 484021000879 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 484021000880 Walker B motif; other site 484021000881 arginine finger; other site 484021000882 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 484021000883 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 484021000884 active site 484021000885 HslU subunit interaction site [polypeptide binding]; other site 484021000886 essential cell division protein FtsN; Provisional; Region: PRK10927 484021000887 cell division protein FtsN; Provisional; Region: PRK12757 484021000888 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021000889 DNA binding site [nucleotide binding] 484021000890 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 484021000891 domain linker motif; other site 484021000892 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 484021000893 dimerization interface [polypeptide binding]; other site 484021000894 ligand binding site [chemical binding]; other site 484021000895 primosome assembly protein PriA; Validated; Region: PRK05580 484021000896 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021000897 ATP binding site [chemical binding]; other site 484021000898 putative Mg++ binding site [ion binding]; other site 484021000899 helicase superfamily c-terminal domain; Region: HELICc; smart00490 484021000900 ATP-binding site [chemical binding]; other site 484021000901 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 484021000902 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 484021000903 dimerization interface [polypeptide binding]; other site 484021000904 DNA binding site [nucleotide binding] 484021000905 corepressor binding sites; other site 484021000906 cystathionine gamma-synthase; Provisional; Region: PRK08045 484021000907 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484021000908 homodimer interface [polypeptide binding]; other site 484021000909 substrate-cofactor binding pocket; other site 484021000910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021000911 catalytic residue [active] 484021000912 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 484021000913 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 484021000914 putative catalytic residues [active] 484021000915 putative nucleotide binding site [chemical binding]; other site 484021000916 putative aspartate binding site [chemical binding]; other site 484021000917 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 484021000918 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 484021000919 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 484021000920 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 484021000921 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 484021000922 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 484021000923 active site 484021000924 metal binding site [ion binding]; metal-binding site 484021000925 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 484021000926 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 484021000927 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 484021000928 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021000929 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 484021000930 dimerization interface [polypeptide binding]; other site 484021000931 substrate binding pocket [chemical binding]; other site 484021000932 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 484021000933 FAD binding site [chemical binding]; other site 484021000934 EamA-like transporter family; Region: EamA; pfam00892 484021000935 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484021000936 EamA-like transporter family; Region: EamA; pfam00892 484021000937 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 484021000938 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 484021000939 dimer interface [polypeptide binding]; other site 484021000940 active site 484021000941 metal binding site [ion binding]; metal-binding site 484021000942 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 484021000943 active site 484021000944 intersubunit interactions; other site 484021000945 catalytic residue [active] 484021000946 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021000947 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021000948 zinc/cadmium-binding protein; Provisional; Region: PRK10306 484021000949 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 484021000950 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 484021000951 acetylornithine deacetylase; Provisional; Region: PRK05111 484021000952 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 484021000953 metal binding site [ion binding]; metal-binding site 484021000954 putative dimer interface [polypeptide binding]; other site 484021000955 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 484021000956 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484021000957 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 484021000958 nucleotide binding site [chemical binding]; other site 484021000959 N-acetyl-L-glutamate binding site [chemical binding]; other site 484021000960 argininosuccinate lyase; Provisional; Region: PRK04833 484021000961 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 484021000962 active sites [active] 484021000963 tetramer interface [polypeptide binding]; other site 484021000964 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 484021000965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021000966 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 484021000967 dimerization interface [polypeptide binding]; other site 484021000968 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 484021000969 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021000970 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484021000971 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 484021000972 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021000973 hypothetical protein; Provisional; Region: PRK11056 484021000974 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 484021000975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021000976 S-adenosylmethionine binding site [chemical binding]; other site 484021000977 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 484021000978 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021000979 N-terminal plug; other site 484021000980 ligand-binding site [chemical binding]; other site 484021000981 glutamate racemase; Provisional; Region: PRK00865 484021000982 transcriptional regulator HdfR; Provisional; Region: PRK03601 484021000983 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021000984 LysR substrate binding domain; Region: LysR_substrate; pfam03466 484021000985 hypothetical protein; Provisional; Region: PRK11027 484021000986 putative ATP-dependent protease; Provisional; Region: PRK09862 484021000987 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 484021000988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021000989 Walker A motif; other site 484021000990 ATP binding site [chemical binding]; other site 484021000991 Walker B motif; other site 484021000992 arginine finger; other site 484021000993 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 484021000994 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 484021000995 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021000996 PYR/PP interface [polypeptide binding]; other site 484021000997 dimer interface [polypeptide binding]; other site 484021000998 TPP binding site [chemical binding]; other site 484021000999 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021001000 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 484021001001 TPP-binding site [chemical binding]; other site 484021001002 dimer interface [polypeptide binding]; other site 484021001003 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 484021001004 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 484021001005 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 484021001006 homodimer interface [polypeptide binding]; other site 484021001007 substrate-cofactor binding pocket; other site 484021001008 catalytic residue [active] 484021001009 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 484021001010 threonine dehydratase; Reviewed; Region: PRK09224 484021001011 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 484021001012 tetramer interface [polypeptide binding]; other site 484021001013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021001014 catalytic residue [active] 484021001015 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 484021001016 putative Ile/Val binding site [chemical binding]; other site 484021001017 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 484021001018 putative Ile/Val binding site [chemical binding]; other site 484021001019 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021001020 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 484021001021 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 484021001022 putative dimerization interface [polypeptide binding]; other site 484021001023 ketol-acid reductoisomerase; Validated; Region: PRK05225 484021001024 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 484021001025 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 484021001026 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 484021001027 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 484021001028 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 484021001029 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 484021001030 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 484021001031 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 484021001032 Part of AAA domain; Region: AAA_19; pfam13245 484021001033 Family description; Region: UvrD_C_2; pfam13538 484021001034 Protein of unknown function (DUF554); Region: DUF554; pfam04474 484021001035 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484021001036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021001037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021001038 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 484021001039 substrate binding pocket [chemical binding]; other site 484021001040 dimerization interface [polypeptide binding]; other site 484021001041 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 484021001042 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 484021001043 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 484021001044 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484021001045 ATP binding site [chemical binding]; other site 484021001046 Mg++ binding site [ion binding]; other site 484021001047 motif III; other site 484021001048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021001049 nucleotide binding region [chemical binding]; other site 484021001050 ATP-binding site [chemical binding]; other site 484021001051 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484021001052 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484021001053 catalytic residues [active] 484021001054 transcription termination factor Rho; Provisional; Region: rho; PRK09376 484021001055 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 484021001056 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 484021001057 RNA binding site [nucleotide binding]; other site 484021001058 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 484021001059 multimer interface [polypeptide binding]; other site 484021001060 Walker A motif; other site 484021001061 ATP binding site [chemical binding]; other site 484021001062 Walker B motif; other site 484021001063 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 484021001064 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 484021001065 Mg++ binding site [ion binding]; other site 484021001066 putative catalytic motif [active] 484021001067 substrate binding site [chemical binding]; other site 484021001068 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 484021001069 Chain length determinant protein; Region: Wzz; pfam02706 484021001070 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 484021001071 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 484021001072 active site 484021001073 homodimer interface [polypeptide binding]; other site 484021001074 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 484021001075 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 484021001076 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 484021001077 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 484021001078 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 484021001079 NAD binding site [chemical binding]; other site 484021001080 substrate binding site [chemical binding]; other site 484021001081 homodimer interface [polypeptide binding]; other site 484021001082 active site 484021001083 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 484021001084 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 484021001085 substrate binding site; other site 484021001086 tetramer interface; other site 484021001087 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 484021001088 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 484021001089 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 484021001090 inhibitor-cofactor binding pocket; inhibition site 484021001091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021001092 catalytic residue [active] 484021001093 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 484021001094 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 484021001095 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 484021001096 putative common antigen polymerase; Provisional; Region: PRK02975 484021001097 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 484021001098 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 484021001099 putative transport protein YifK; Provisional; Region: PRK10746 484021001100 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 484021001101 HemY protein N-terminus; Region: HemY_N; pfam07219 484021001102 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 484021001103 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 484021001104 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 484021001105 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 484021001106 active site 484021001107 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 484021001108 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 484021001109 domain interfaces; other site 484021001110 active site 484021001111 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 484021001112 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 484021001113 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 484021001114 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 484021001115 putative iron binding site [ion binding]; other site 484021001116 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 484021001117 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 484021001118 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 484021001119 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 484021001120 hypothetical protein; Provisional; Region: PRK10963 484021001121 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 484021001122 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 484021001123 active site 484021001124 Int/Topo IB signature motif; other site 484021001125 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 484021001126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021001127 motif II; other site 484021001128 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 484021001129 Part of AAA domain; Region: AAA_19; pfam13245 484021001130 Family description; Region: UvrD_C_2; pfam13538 484021001131 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 484021001132 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 484021001133 Cl binding site [ion binding]; other site 484021001134 oligomer interface [polypeptide binding]; other site 484021001135 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 484021001136 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 484021001137 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484021001138 CoenzymeA binding site [chemical binding]; other site 484021001139 subunit interaction site [polypeptide binding]; other site 484021001140 PHB binding site; other site 484021001141 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 484021001142 dimerization interface [polypeptide binding]; other site 484021001143 substrate binding site [chemical binding]; other site 484021001144 active site 484021001145 calcium binding site [ion binding]; other site 484021001146 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 484021001147 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021001148 ATP binding site [chemical binding]; other site 484021001149 putative Mg++ binding site [ion binding]; other site 484021001150 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021001151 nucleotide binding region [chemical binding]; other site 484021001152 ATP-binding site [chemical binding]; other site 484021001153 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 484021001154 Helicase and RNase D C-terminal; Region: HRDC; smart00341 484021001155 threonine efflux system; Provisional; Region: PRK10229 484021001156 putative transposase; Provisional; Region: PRK09857 484021001157 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021001158 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 484021001159 lysophospholipase L2; Provisional; Region: PRK10749 484021001160 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 484021001161 putative hydrolase; Provisional; Region: PRK10976 484021001162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021001163 active site 484021001164 motif I; other site 484021001165 motif II; other site 484021001166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021001167 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484021001168 EamA-like transporter family; Region: EamA; pfam00892 484021001169 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 484021001170 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021001171 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 484021001172 putative dimerization interface [polypeptide binding]; other site 484021001173 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 484021001174 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 484021001175 THF binding site; other site 484021001176 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 484021001177 substrate binding site [chemical binding]; other site 484021001178 THF binding site; other site 484021001179 zinc-binding site [ion binding]; other site 484021001180 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 484021001181 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484021001182 uridine phosphorylase; Provisional; Region: PRK11178 484021001183 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 484021001184 DNA recombination protein RmuC; Provisional; Region: PRK10361 484021001185 RmuC family; Region: RmuC; pfam02646 484021001186 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 484021001187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021001188 S-adenosylmethionine binding site [chemical binding]; other site 484021001189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 484021001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 484021001191 SCP-2 sterol transfer family; Region: SCP2; pfam02036 484021001192 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 484021001193 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 484021001194 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 484021001195 sec-independent translocase; Provisional; Region: PRK01770 484021001196 sec-independent translocase; Provisional; Region: tatB; PRK00404 484021001197 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 484021001198 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484021001199 active site 484021001200 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 484021001201 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 484021001202 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 484021001203 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 484021001204 FMN reductase; Validated; Region: fre; PRK08051 484021001205 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 484021001206 FAD binding pocket [chemical binding]; other site 484021001207 FAD binding motif [chemical binding]; other site 484021001208 phosphate binding motif [ion binding]; other site 484021001209 beta-alpha-beta structure motif; other site 484021001210 NAD binding pocket [chemical binding]; other site 484021001211 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 484021001212 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021001213 dimer interface [polypeptide binding]; other site 484021001214 active site 484021001215 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 484021001216 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 484021001217 substrate binding site [chemical binding]; other site 484021001218 oxyanion hole (OAH) forming residues; other site 484021001219 trimer interface [polypeptide binding]; other site 484021001220 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 484021001221 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021001222 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021001223 proline dipeptidase; Provisional; Region: PRK13607 484021001224 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 484021001225 active site 484021001226 hypothetical protein; Provisional; Region: PRK11568 484021001227 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 484021001228 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 484021001229 potassium transporter; Provisional; Region: PRK10750 484021001230 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 484021001231 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 484021001232 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 484021001233 FAD binding domain; Region: FAD_binding_4; pfam01565 484021001234 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 484021001235 Biotin operon repressor [Transcription]; Region: BirA; COG1654 484021001236 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 484021001237 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 484021001238 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 484021001239 pantothenate kinase; Provisional; Region: PRK05439 484021001240 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 484021001241 ATP-binding site [chemical binding]; other site 484021001242 CoA-binding site [chemical binding]; other site 484021001243 Mg2+-binding site [ion binding]; other site 484021001244 elongation factor Tu; Reviewed; Region: PRK00049 484021001245 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 484021001246 G1 box; other site 484021001247 GEF interaction site [polypeptide binding]; other site 484021001248 GTP/Mg2+ binding site [chemical binding]; other site 484021001249 Switch I region; other site 484021001250 G2 box; other site 484021001251 G3 box; other site 484021001252 Switch II region; other site 484021001253 G4 box; other site 484021001254 G5 box; other site 484021001255 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 484021001256 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 484021001257 Antibiotic Binding Site [chemical binding]; other site 484021001258 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 484021001259 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 484021001260 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 484021001261 putative homodimer interface [polypeptide binding]; other site 484021001262 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 484021001263 heterodimer interface [polypeptide binding]; other site 484021001264 homodimer interface [polypeptide binding]; other site 484021001265 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 484021001266 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 484021001267 23S rRNA interface [nucleotide binding]; other site 484021001268 L7/L12 interface [polypeptide binding]; other site 484021001269 putative thiostrepton binding site; other site 484021001270 L25 interface [polypeptide binding]; other site 484021001271 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 484021001272 mRNA/rRNA interface [nucleotide binding]; other site 484021001273 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 484021001274 23S rRNA interface [nucleotide binding]; other site 484021001275 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 484021001276 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 484021001277 core dimer interface [polypeptide binding]; other site 484021001278 peripheral dimer interface [polypeptide binding]; other site 484021001279 L10 interface [polypeptide binding]; other site 484021001280 L11 interface [polypeptide binding]; other site 484021001281 putative EF-Tu interaction site [polypeptide binding]; other site 484021001282 putative EF-G interaction site [polypeptide binding]; other site 484021001283 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 484021001284 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 484021001285 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 484021001286 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484021001287 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 484021001288 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484021001289 RPB3 interaction site [polypeptide binding]; other site 484021001290 RPB1 interaction site [polypeptide binding]; other site 484021001291 RPB11 interaction site [polypeptide binding]; other site 484021001292 RPB10 interaction site [polypeptide binding]; other site 484021001293 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 484021001294 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 484021001295 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 484021001296 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 484021001297 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 484021001298 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 484021001299 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484021001300 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 484021001301 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484021001302 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 484021001303 DNA binding site [nucleotide binding] 484021001304 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 484021001305 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 484021001306 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 484021001307 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 484021001308 methionine cluster; other site 484021001309 active site 484021001310 phosphorylation site [posttranslational modification] 484021001311 metal binding site [ion binding]; metal-binding site 484021001312 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484021001313 active site 484021001314 P-loop; other site 484021001315 phosphorylation site [posttranslational modification] 484021001316 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021001317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021001318 metal binding site [ion binding]; metal-binding site 484021001319 active site 484021001320 I-site; other site 484021001321 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 484021001322 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021001323 FeS/SAM binding site; other site 484021001324 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 484021001325 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 484021001326 ThiS interaction site; other site 484021001327 putative active site [active] 484021001328 tetramer interface [polypeptide binding]; other site 484021001329 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 484021001330 thiS-thiF/thiG interaction site; other site 484021001331 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 484021001332 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 484021001333 ATP binding site [chemical binding]; other site 484021001334 substrate interface [chemical binding]; other site 484021001335 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 484021001336 thiamine phosphate binding site [chemical binding]; other site 484021001337 active site 484021001338 pyrophosphate binding site [ion binding]; other site 484021001339 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 484021001340 ThiC-associated domain; Region: ThiC-associated; pfam13667 484021001341 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 484021001342 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 484021001343 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 484021001344 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 484021001345 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 484021001346 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 484021001347 putative NADH binding site [chemical binding]; other site 484021001348 putative active site [active] 484021001349 nudix motif; other site 484021001350 putative metal binding site [ion binding]; other site 484021001351 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 484021001352 substrate binding site [chemical binding]; other site 484021001353 active site 484021001354 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 484021001355 Active_site [active] 484021001356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 484021001357 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 484021001358 IHF dimer interface [polypeptide binding]; other site 484021001359 IHF - DNA interface [nucleotide binding]; other site 484021001360 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 484021001361 zinc resistance protein; Provisional; Region: zraP; PRK11546 484021001362 dimer interface [polypeptide binding]; other site 484021001363 sensor protein ZraS; Provisional; Region: PRK10364 484021001364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021001365 dimer interface [polypeptide binding]; other site 484021001366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021001367 ATP binding site [chemical binding]; other site 484021001368 Mg2+ binding site [ion binding]; other site 484021001369 G-X-G motif; other site 484021001370 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 484021001371 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021001372 active site 484021001373 phosphorylation site [posttranslational modification] 484021001374 intermolecular recognition site; other site 484021001375 dimerization interface [polypeptide binding]; other site 484021001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021001377 Walker A motif; other site 484021001378 ATP binding site [chemical binding]; other site 484021001379 Walker B motif; other site 484021001380 arginine finger; other site 484021001381 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021001382 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 484021001383 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 484021001384 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 484021001385 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 484021001386 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 484021001387 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 484021001388 purine monophosphate binding site [chemical binding]; other site 484021001389 dimer interface [polypeptide binding]; other site 484021001390 putative catalytic residues [active] 484021001391 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 484021001392 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 484021001393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021001394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021001395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484021001396 Coenzyme A binding pocket [chemical binding]; other site 484021001397 homoserine O-succinyltransferase; Provisional; Region: PRK05368 484021001398 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 484021001399 proposed active site lysine [active] 484021001400 conserved cys residue [active] 484021001401 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 484021001402 malate synthase A; Region: malate_syn_A; TIGR01344 484021001403 active site 484021001404 isocitrate lyase; Provisional; Region: PRK15063 484021001405 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 484021001406 tetramer interface [polypeptide binding]; other site 484021001407 active site 484021001408 Mg2+/Mn2+ binding site [ion binding]; other site 484021001409 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 484021001410 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 484021001411 transcriptional repressor IclR; Provisional; Region: PRK11569 484021001412 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021001413 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021001414 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 484021001415 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 484021001416 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 484021001417 substrate binding pocket [chemical binding]; other site 484021001418 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 484021001419 B12 binding site [chemical binding]; other site 484021001420 cobalt ligand [ion binding]; other site 484021001421 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 484021001422 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 484021001423 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 484021001424 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 484021001425 active site pocket [active] 484021001426 oxyanion hole [active] 484021001427 catalytic triad [active] 484021001428 active site nucleophile [active] 484021001429 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 484021001430 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021001431 RNA binding surface [nucleotide binding]; other site 484021001432 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 484021001433 probable active site [active] 484021001434 hypothetical protein; Provisional; Region: PRK10515 484021001435 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 484021001436 Sodium Bile acid symporter family; Region: SBF; pfam01758 484021001437 aspartate kinase III; Validated; Region: PRK09084 484021001438 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 484021001439 nucleotide binding site [chemical binding]; other site 484021001440 substrate binding site [chemical binding]; other site 484021001441 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 484021001442 lysine allosteric regulatory site; other site 484021001443 dimer interface [polypeptide binding]; other site 484021001444 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 484021001445 dimer interface [polypeptide binding]; other site 484021001446 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 484021001447 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 484021001448 active site 484021001449 dimer interface [polypeptide binding]; other site 484021001450 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 484021001451 dimer interface [polypeptide binding]; other site 484021001452 active site 484021001453 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 484021001454 putative trimer interface [polypeptide binding]; other site 484021001455 putative active site [active] 484021001456 putative substrate binding site [chemical binding]; other site 484021001457 putative CoA binding site [chemical binding]; other site 484021001458 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484021001459 homotrimer interaction site [polypeptide binding]; other site 484021001460 putative active site [active] 484021001461 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 484021001462 AzlC protein; Region: AzlC; pfam03591 484021001463 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 484021001464 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 484021001465 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484021001466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021001467 dimer interface [polypeptide binding]; other site 484021001468 conserved gate region; other site 484021001469 putative PBP binding loops; other site 484021001470 ABC-ATPase subunit interface; other site 484021001471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021001472 dimer interface [polypeptide binding]; other site 484021001473 conserved gate region; other site 484021001474 putative PBP binding loops; other site 484021001475 ABC-ATPase subunit interface; other site 484021001476 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 484021001477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 484021001478 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 484021001479 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 484021001480 Walker A/P-loop; other site 484021001481 ATP binding site [chemical binding]; other site 484021001482 Q-loop/lid; other site 484021001483 ABC transporter signature motif; other site 484021001484 Walker B; other site 484021001485 D-loop; other site 484021001486 H-loop/switch region; other site 484021001487 TOBE domain; Region: TOBE_2; pfam08402 484021001488 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 484021001489 trimer interface; other site 484021001490 sugar binding site [chemical binding]; other site 484021001491 maltose regulon periplasmic protein; Provisional; Region: PRK10564 484021001492 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 484021001493 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 484021001494 UbiA prenyltransferase family; Region: UbiA; pfam01040 484021001495 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 484021001496 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 484021001497 putative acyl-acceptor binding pocket; other site 484021001498 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 484021001499 LexA repressor; Validated; Region: PRK00215 484021001500 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 484021001501 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 484021001502 Catalytic site [active] 484021001503 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 484021001504 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 484021001505 hypothetical protein; Provisional; Region: PRK10428 484021001506 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484021001507 metal binding site 2 [ion binding]; metal-binding site 484021001508 putative DNA binding helix; other site 484021001509 metal binding site 1 [ion binding]; metal-binding site 484021001510 dimer interface [polypeptide binding]; other site 484021001511 structural Zn2+ binding site [ion binding]; other site 484021001512 Cupin domain; Region: Cupin_2; cl17218 484021001513 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 484021001514 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 484021001515 FMN binding site [chemical binding]; other site 484021001516 active site 484021001517 catalytic residues [active] 484021001518 substrate binding site [chemical binding]; other site 484021001519 phage shock protein G; Reviewed; Region: pspG; PRK09459 484021001520 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 484021001521 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 484021001522 NADP binding site [chemical binding]; other site 484021001523 dimer interface [polypeptide binding]; other site 484021001524 replicative DNA helicase; Provisional; Region: PRK08006 484021001525 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 484021001526 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 484021001527 Walker A motif; other site 484021001528 ATP binding site [chemical binding]; other site 484021001529 Walker B motif; other site 484021001530 DNA binding loops [nucleotide binding] 484021001531 alanine racemase; Reviewed; Region: alr; PRK00053 484021001532 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 484021001533 active site 484021001534 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484021001535 substrate binding site [chemical binding]; other site 484021001536 catalytic residues [active] 484021001537 dimer interface [polypeptide binding]; other site 484021001538 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 484021001539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021001540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021001541 homodimer interface [polypeptide binding]; other site 484021001542 catalytic residue [active] 484021001543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021001544 active site 484021001545 motif I; other site 484021001546 motif II; other site 484021001547 Uncharacterized conserved protein [Function unknown]; Region: COG0432 484021001548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 484021001549 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 484021001550 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 484021001551 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 484021001552 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 484021001553 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 484021001554 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 484021001555 dimer interface [polypeptide binding]; other site 484021001556 ssDNA binding site [nucleotide binding]; other site 484021001557 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021001558 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 484021001559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021001560 substrate binding pocket [chemical binding]; other site 484021001561 membrane-bound complex binding site; other site 484021001562 hinge residues; other site 484021001563 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021001564 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021001565 catalytic residue [active] 484021001566 outer membrane receptor FepA; Provisional; Region: PRK13524 484021001567 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021001568 N-terminal plug; other site 484021001569 ligand-binding site [chemical binding]; other site 484021001570 potential frameshift: common BLAST hit: gi|152972925|ref|YP_001338071.1| regulation of superoxide response regulon 484021001571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021001572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021001573 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 484021001574 Tannase and feruloyl esterase; Region: Tannase; pfam07519 484021001575 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 484021001576 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021001577 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021001578 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021001579 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021001580 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021001581 Surface antigen; Region: Bac_surface_Ag; pfam01103 484021001582 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 484021001583 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 484021001584 active site 484021001585 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021001586 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 484021001587 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 484021001588 putative dimerization interface [polypeptide binding]; other site 484021001589 putative ligand binding site [chemical binding]; other site 484021001590 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 484021001591 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 484021001592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021001593 Walker A/P-loop; other site 484021001594 ATP binding site [chemical binding]; other site 484021001595 Q-loop/lid; other site 484021001596 ABC transporter signature motif; other site 484021001597 Walker B; other site 484021001598 D-loop; other site 484021001599 H-loop/switch region; other site 484021001600 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 484021001601 hypothetical protein; Provisional; Region: PRK11622 484021001602 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021001603 dimer interface [polypeptide binding]; other site 484021001604 conserved gate region; other site 484021001605 putative PBP binding loops; other site 484021001606 ABC-ATPase subunit interface; other site 484021001607 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484021001608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021001609 dimer interface [polypeptide binding]; other site 484021001610 conserved gate region; other site 484021001611 putative PBP binding loops; other site 484021001612 ABC-ATPase subunit interface; other site 484021001613 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 484021001614 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 484021001615 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021001616 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 484021001617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021001618 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 484021001619 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 484021001620 DNA binding residues [nucleotide binding] 484021001621 dimer interface [polypeptide binding]; other site 484021001622 [2Fe-2S] cluster binding site [ion binding]; other site 484021001623 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484021001624 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 484021001625 putative C-terminal domain interface [polypeptide binding]; other site 484021001626 putative GSH binding site (G-site) [chemical binding]; other site 484021001627 putative dimer interface [polypeptide binding]; other site 484021001628 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 484021001629 putative N-terminal domain interface [polypeptide binding]; other site 484021001630 putative dimer interface [polypeptide binding]; other site 484021001631 putative substrate binding pocket (H-site) [chemical binding]; other site 484021001632 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 484021001633 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 484021001634 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 484021001635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021001636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021001637 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 484021001638 putative dimerization interface [polypeptide binding]; other site 484021001639 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 484021001640 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 484021001641 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021001642 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 484021001643 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021001644 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021001645 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021001646 PapC N-terminal domain; Region: PapC_N; pfam13954 484021001647 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021001648 PapC C-terminal domain; Region: PapC_C; pfam13953 484021001649 Fimbrial protein; Region: Fimbrial; cl01416 484021001650 putative major fimbrial protein SthE; Provisional; Region: PRK15292 484021001651 Fimbrial protein; Region: Fimbrial; cl01416 484021001652 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 484021001653 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 484021001654 Na binding site [ion binding]; other site 484021001655 Predicted membrane protein [Function unknown]; Region: COG3162 484021001656 acetyl-CoA synthetase; Provisional; Region: PRK00174 484021001657 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 484021001658 active site 484021001659 CoA binding site [chemical binding]; other site 484021001660 acyl-activating enzyme (AAE) consensus motif; other site 484021001661 AMP binding site [chemical binding]; other site 484021001662 acetate binding site [chemical binding]; other site 484021001663 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 484021001664 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484021001665 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 484021001666 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 484021001667 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 484021001668 [4Fe-4S] binding site [ion binding]; other site 484021001669 molybdopterin cofactor binding site; other site 484021001670 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 484021001671 molybdopterin cofactor binding site; other site 484021001672 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484021001673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021001674 active site 484021001675 phosphorylation site [posttranslational modification] 484021001676 intermolecular recognition site; other site 484021001677 dimerization interface [polypeptide binding]; other site 484021001678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021001679 DNA binding site [nucleotide binding] 484021001680 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 484021001681 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021001682 substrate binding site [chemical binding]; other site 484021001683 ATP binding site [chemical binding]; other site 484021001684 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 484021001685 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 484021001686 putative ligand binding site [chemical binding]; other site 484021001687 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021001688 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021001689 TM-ABC transporter signature motif; other site 484021001690 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021001691 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021001692 Walker A/P-loop; other site 484021001693 ATP binding site [chemical binding]; other site 484021001694 Q-loop/lid; other site 484021001695 ABC transporter signature motif; other site 484021001696 Walker B; other site 484021001697 D-loop; other site 484021001698 H-loop/switch region; other site 484021001699 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021001700 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021001701 dimerization interface [polypeptide binding]; other site 484021001702 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021001703 dimer interface [polypeptide binding]; other site 484021001704 phosphorylation site [posttranslational modification] 484021001705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021001706 ATP binding site [chemical binding]; other site 484021001707 Mg2+ binding site [ion binding]; other site 484021001708 G-X-G motif; other site 484021001709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021001710 active site 484021001711 phosphorylation site [posttranslational modification] 484021001712 intermolecular recognition site; other site 484021001713 putative hydrolase; Provisional; Region: PRK02113 484021001714 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 484021001715 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 484021001716 active site 484021001717 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 484021001718 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484021001719 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 484021001720 active site 484021001721 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 484021001722 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021001723 Walker A/P-loop; other site 484021001724 ATP binding site [chemical binding]; other site 484021001725 Q-loop/lid; other site 484021001726 ABC transporter signature motif; other site 484021001727 Walker B; other site 484021001728 D-loop; other site 484021001729 H-loop/switch region; other site 484021001730 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 484021001731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021001732 Walker A/P-loop; other site 484021001733 ATP binding site [chemical binding]; other site 484021001734 Q-loop/lid; other site 484021001735 ABC transporter signature motif; other site 484021001736 Walker B; other site 484021001737 D-loop; other site 484021001738 H-loop/switch region; other site 484021001739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021001740 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 484021001741 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 484021001742 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 484021001743 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 484021001744 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 484021001745 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021001746 DNA-binding site [nucleotide binding]; DNA binding site 484021001747 UTRA domain; Region: UTRA; pfam07702 484021001748 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 484021001749 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021001750 dimer interface [polypeptide binding]; other site 484021001751 hypothetical protein; Provisional; Region: PRK10220 484021001752 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 484021001753 PhnA protein; Region: PhnA; pfam03831 484021001754 proline/glycine betaine transporter; Provisional; Region: PRK10642 484021001755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021001756 putative substrate translocation pore; other site 484021001757 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 484021001758 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 484021001759 Cupin domain; Region: Cupin_2; cl17218 484021001760 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021001761 alpha-galactosidase; Provisional; Region: PRK15076 484021001762 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 484021001763 NAD binding site [chemical binding]; other site 484021001764 sugar binding site [chemical binding]; other site 484021001765 divalent metal binding site [ion binding]; other site 484021001766 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021001767 dimer interface [polypeptide binding]; other site 484021001768 melibiose:sodium symporter; Provisional; Region: PRK10429 484021001769 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 484021001770 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 484021001771 PRTRC system protein D; Region: PRTRC_D; TIGR03739 484021001772 Mg binding site [ion binding]; other site 484021001773 nucleotide binding site [chemical binding]; other site 484021001774 putative protofilament interface [polypeptide binding]; other site 484021001775 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 484021001776 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 484021001777 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 484021001778 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 484021001779 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484021001780 HSP70 interaction site [polypeptide binding]; other site 484021001781 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 484021001782 substrate binding site [polypeptide binding]; other site 484021001783 dimer interface [polypeptide binding]; other site 484021001784 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 484021001785 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 484021001786 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 484021001787 catalytic residues [active] 484021001788 hemin storage system protein; Provisional; Region: hmsS; PRK14584 484021001789 N-glycosyltransferase; Provisional; Region: PRK11204 484021001790 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 484021001791 DXD motif; other site 484021001792 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 484021001793 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 484021001794 putative active site [active] 484021001795 putative metal binding site [ion binding]; other site 484021001796 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 484021001797 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 484021001798 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 484021001799 dimerization interface [polypeptide binding]; other site 484021001800 DNA binding residues [nucleotide binding] 484021001801 PerC transcriptional activator; Region: PerC; pfam06069 484021001802 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 484021001803 putative transcriptional regulator; Provisional; Region: PRK11640 484021001804 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 484021001805 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 484021001806 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 484021001807 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 484021001808 DsbD alpha interface [polypeptide binding]; other site 484021001809 catalytic residues [active] 484021001810 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 484021001811 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 484021001812 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 484021001813 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 484021001814 Aspartase; Region: Aspartase; cd01357 484021001815 active sites [active] 484021001816 tetramer interface [polypeptide binding]; other site 484021001817 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 484021001818 putative transporter; Provisional; Region: PRK11021 484021001819 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 484021001820 oligomerisation interface [polypeptide binding]; other site 484021001821 mobile loop; other site 484021001822 roof hairpin; other site 484021001823 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 484021001824 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 484021001825 ring oligomerisation interface [polypeptide binding]; other site 484021001826 ATP/Mg binding site [chemical binding]; other site 484021001827 stacking interactions; other site 484021001828 hinge regions; other site 484021001829 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 484021001830 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 484021001831 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 484021001832 putative active site [active] 484021001833 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021001834 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 484021001835 Walker A/P-loop; other site 484021001836 ATP binding site [chemical binding]; other site 484021001837 Q-loop/lid; other site 484021001838 ABC transporter signature motif; other site 484021001839 Walker B; other site 484021001840 D-loop; other site 484021001841 H-loop/switch region; other site 484021001842 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 484021001843 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021001844 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021001845 putative major fimbrial protein SthE; Provisional; Region: PRK15292 484021001846 Fimbrial protein; Region: Fimbrial; pfam00419 484021001847 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021001848 PapC N-terminal domain; Region: PapC_N; pfam13954 484021001849 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021001850 PapC C-terminal domain; Region: PapC_C; pfam13953 484021001851 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021001852 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021001853 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021001854 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021001855 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 484021001856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484021001857 DNA binding site [nucleotide binding] 484021001858 elongation factor P; Validated; Region: PRK00529 484021001859 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 484021001860 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 484021001861 RNA binding site [nucleotide binding]; other site 484021001862 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 484021001863 RNA binding site [nucleotide binding]; other site 484021001864 Predicted small secreted protein [Function unknown]; Region: COG5510 484021001865 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 484021001866 multidrug efflux system protein; Provisional; Region: PRK11431 484021001867 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 484021001868 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 484021001869 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 484021001870 Iron-sulfur protein interface; other site 484021001871 proximal quinone binding site [chemical binding]; other site 484021001872 C-subunit interface; other site 484021001873 distal quinone binding site; other site 484021001874 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 484021001875 D-subunit interface [polypeptide binding]; other site 484021001876 Iron-sulfur protein interface; other site 484021001877 proximal quinone binding site [chemical binding]; other site 484021001878 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 484021001879 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 484021001880 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 484021001881 L-aspartate oxidase; Provisional; Region: PRK06175 484021001882 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484021001883 poxB regulator PoxA; Provisional; Region: PRK09350 484021001884 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484021001885 motif 1; other site 484021001886 dimer interface [polypeptide binding]; other site 484021001887 active site 484021001888 motif 2; other site 484021001889 motif 3; other site 484021001890 inner membrane transporter YjeM; Provisional; Region: PRK15238 484021001891 putative mechanosensitive channel protein; Provisional; Region: PRK10929 484021001892 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 484021001893 putative YPXnL-motif binding site; other site 484021001894 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 484021001895 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021001896 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 484021001897 GTPase RsgA; Reviewed; Region: PRK12288 484021001898 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484021001899 RNA binding site [nucleotide binding]; other site 484021001900 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 484021001901 GTPase/Zn-binding domain interface [polypeptide binding]; other site 484021001902 GTP/Mg2+ binding site [chemical binding]; other site 484021001903 G4 box; other site 484021001904 G5 box; other site 484021001905 G1 box; other site 484021001906 Switch I region; other site 484021001907 G2 box; other site 484021001908 G3 box; other site 484021001909 Switch II region; other site 484021001910 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 484021001911 catalytic site [active] 484021001912 putative active site [active] 484021001913 putative substrate binding site [chemical binding]; other site 484021001914 dimer interface [polypeptide binding]; other site 484021001915 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021001916 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021001917 substrate binding pocket [chemical binding]; other site 484021001918 membrane-bound complex binding site; other site 484021001919 hinge residues; other site 484021001920 epoxyqueuosine reductase; Region: TIGR00276 484021001921 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 484021001922 putative carbohydrate kinase; Provisional; Region: PRK10565 484021001923 Uncharacterized conserved protein [Function unknown]; Region: COG0062 484021001924 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 484021001925 putative substrate binding site [chemical binding]; other site 484021001926 putative ATP binding site [chemical binding]; other site 484021001927 ADP-binding protein; Provisional; Region: PRK10646 484021001928 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 484021001929 AMIN domain; Region: AMIN; pfam11741 484021001930 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 484021001931 active site 484021001932 metal binding site [ion binding]; metal-binding site 484021001933 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 484021001934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021001935 ATP binding site [chemical binding]; other site 484021001936 Mg2+ binding site [ion binding]; other site 484021001937 G-X-G motif; other site 484021001938 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 484021001939 ATP binding site [chemical binding]; other site 484021001940 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 484021001941 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 484021001942 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 484021001943 bacterial Hfq-like; Region: Hfq; cd01716 484021001944 hexamer interface [polypeptide binding]; other site 484021001945 Sm1 motif; other site 484021001946 RNA binding site [nucleotide binding]; other site 484021001947 Sm2 motif; other site 484021001948 GTPase HflX; Provisional; Region: PRK11058 484021001949 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 484021001950 HflX GTPase family; Region: HflX; cd01878 484021001951 G1 box; other site 484021001952 GTP/Mg2+ binding site [chemical binding]; other site 484021001953 Switch I region; other site 484021001954 G2 box; other site 484021001955 G3 box; other site 484021001956 Switch II region; other site 484021001957 G4 box; other site 484021001958 G5 box; other site 484021001959 FtsH protease regulator HflK; Provisional; Region: PRK10930 484021001960 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 484021001961 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 484021001962 FtsH protease regulator HflC; Provisional; Region: PRK11029 484021001963 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 484021001964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 484021001965 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 484021001966 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 484021001967 GDP-binding site [chemical binding]; other site 484021001968 ACT binding site; other site 484021001969 IMP binding site; other site 484021001970 Predicted transcriptional regulator [Transcription]; Region: COG1959 484021001971 transcriptional repressor NsrR; Provisional; Region: PRK11014 484021001972 exoribonuclease R; Provisional; Region: PRK11642 484021001973 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 484021001974 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 484021001975 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484021001976 RNB domain; Region: RNB; pfam00773 484021001977 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 484021001978 RNA binding site [nucleotide binding]; other site 484021001979 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 484021001980 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 484021001981 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 484021001982 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 484021001983 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 484021001984 active site 484021001985 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021001986 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 484021001987 esterase; Provisional; Region: PRK10566 484021001988 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484021001989 transcriptional repressor UlaR; Provisional; Region: PRK13509 484021001990 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 484021001991 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021001992 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 484021001993 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 484021001994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 484021001995 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 484021001996 active site 484021001997 P-loop; other site 484021001998 phosphorylation site [posttranslational modification] 484021001999 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021002000 active site 484021002001 phosphorylation site [posttranslational modification] 484021002002 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 484021002003 active site 484021002004 dimer interface [polypeptide binding]; other site 484021002005 magnesium binding site [ion binding]; other site 484021002006 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 484021002007 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 484021002008 AP (apurinic/apyrimidinic) site pocket; other site 484021002009 DNA interaction; other site 484021002010 Metal-binding active site; metal-binding site 484021002011 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 484021002012 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 484021002013 intersubunit interface [polypeptide binding]; other site 484021002014 active site 484021002015 Zn2+ binding site [ion binding]; other site 484021002016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021002017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021002018 putative substrate translocation pore; other site 484021002019 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021002020 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 484021002021 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 484021002022 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 484021002023 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 484021002024 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 484021002025 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 484021002026 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 484021002027 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 484021002028 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 484021002029 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484021002030 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 484021002031 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484021002032 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 484021002033 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 484021002034 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 484021002035 Hemerythrin-like domain; Region: Hr-like; cd12108 484021002036 Fe binding site [ion binding]; other site 484021002037 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021002038 EamA-like transporter family; Region: EamA; pfam00892 484021002039 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021002040 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484021002041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002043 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 484021002044 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 484021002045 NADP binding site [chemical binding]; other site 484021002046 Predicted transcriptional regulators [Transcription]; Region: COG1733 484021002047 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 484021002048 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 484021002049 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 484021002050 active site 484021002051 metal binding site [ion binding]; metal-binding site 484021002052 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 484021002053 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 484021002054 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 484021002055 active site 484021002056 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 484021002057 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 484021002058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002059 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484021002060 Domain of unknown function DUF21; Region: DUF21; pfam01595 484021002061 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484021002062 Transporter associated domain; Region: CorC_HlyC; smart01091 484021002063 methionine sulfoxide reductase A; Provisional; Region: PRK00058 484021002064 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 484021002065 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021002066 Surface antigen; Region: Bac_surface_Ag; pfam01103 484021002067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 484021002068 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 484021002069 Family of unknown function (DUF490); Region: DUF490; pfam04357 484021002070 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 484021002071 putative active site pocket [active] 484021002072 dimerization interface [polypeptide binding]; other site 484021002073 putative catalytic residue [active] 484021002074 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 484021002075 dimer interface [polypeptide binding]; other site 484021002076 substrate binding site [chemical binding]; other site 484021002077 metal binding sites [ion binding]; metal-binding site 484021002078 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 484021002079 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 484021002080 putative ligand binding site [chemical binding]; other site 484021002081 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021002082 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021002083 Walker A/P-loop; other site 484021002084 ATP binding site [chemical binding]; other site 484021002085 Q-loop/lid; other site 484021002086 ABC transporter signature motif; other site 484021002087 Walker B; other site 484021002088 D-loop; other site 484021002089 H-loop/switch region; other site 484021002090 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021002091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021002092 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021002093 TM-ABC transporter signature motif; other site 484021002094 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021002095 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021002096 TM-ABC transporter signature motif; other site 484021002097 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 484021002098 AMP binding site [chemical binding]; other site 484021002099 metal binding site [ion binding]; metal-binding site 484021002100 active site 484021002101 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 484021002102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484021002103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484021002104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484021002105 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484021002106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021002107 Coenzyme A binding pocket [chemical binding]; other site 484021002108 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 484021002109 active site 484021002110 catalytic residues [active] 484021002111 hypothetical protein; Provisional; Region: PRK05255 484021002112 peptidase PmbA; Provisional; Region: PRK11040 484021002113 Cytochrome b562; Region: Cytochrom_B562; cl01546 484021002114 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 484021002115 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 484021002116 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 484021002117 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 484021002118 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 484021002119 dihydroorotase; Provisional; Region: PRK09237 484021002120 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 484021002121 active site 484021002122 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 484021002123 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 484021002124 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 484021002125 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 484021002126 HTH domain; Region: HTH_11; pfam08279 484021002127 Mga helix-turn-helix domain; Region: Mga; pfam05043 484021002128 PRD domain; Region: PRD; pfam00874 484021002129 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 484021002130 active site 484021002131 P-loop; other site 484021002132 phosphorylation site [posttranslational modification] 484021002133 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021002134 active site 484021002135 phosphorylation site [posttranslational modification] 484021002136 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 484021002137 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 484021002138 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 484021002139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021002140 FeS/SAM binding site; other site 484021002141 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 484021002142 ATP cone domain; Region: ATP-cone; pfam03477 484021002143 Class III ribonucleotide reductase; Region: RNR_III; cd01675 484021002144 effector binding site; other site 484021002145 active site 484021002146 Zn binding site [ion binding]; other site 484021002147 glycine loop; other site 484021002148 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021002149 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021002150 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021002151 putative active site [active] 484021002152 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484021002153 active site 484021002154 P-loop; other site 484021002155 phosphorylation site [posttranslational modification] 484021002156 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 484021002157 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 484021002158 NAD binding site [chemical binding]; other site 484021002159 sugar binding site [chemical binding]; other site 484021002160 divalent metal binding site [ion binding]; other site 484021002161 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021002162 dimer interface [polypeptide binding]; other site 484021002163 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021002164 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 484021002165 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 484021002166 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 484021002167 Ca binding site [ion binding]; other site 484021002168 active site 484021002169 catalytic site [active] 484021002170 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 484021002171 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 484021002172 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021002173 active site turn [active] 484021002174 phosphorylation site [posttranslational modification] 484021002175 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021002176 trehalose repressor; Provisional; Region: treR; PRK09492 484021002177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021002178 DNA binding site [nucleotide binding] 484021002179 domain linker motif; other site 484021002180 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 484021002181 dimerization interface [polypeptide binding]; other site 484021002182 ligand binding site [chemical binding]; other site 484021002183 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 484021002184 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 484021002185 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021002186 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 484021002187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021002188 motif II; other site 484021002189 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484021002190 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484021002191 homotrimer interaction site [polypeptide binding]; other site 484021002192 putative active site [active] 484021002193 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 484021002194 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 484021002195 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 484021002196 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 484021002197 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484021002198 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484021002199 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 484021002200 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 484021002201 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484021002202 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484021002203 RNase E inhibitor protein; Provisional; Region: PRK11191 484021002204 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 484021002205 active site 484021002206 dinuclear metal binding site [ion binding]; other site 484021002207 dimerization interface [polypeptide binding]; other site 484021002208 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021002209 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 484021002210 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 484021002211 HIGH motif; other site 484021002212 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 484021002213 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 484021002214 active site 484021002215 KMSKS motif; other site 484021002216 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 484021002217 tRNA binding surface [nucleotide binding]; other site 484021002218 anticodon binding site; other site 484021002219 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 484021002220 DNA polymerase III subunit chi; Validated; Region: PRK05728 484021002221 multifunctional aminopeptidase A; Provisional; Region: PRK00913 484021002222 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 484021002223 interface (dimer of trimers) [polypeptide binding]; other site 484021002224 Substrate-binding/catalytic site; other site 484021002225 Zn-binding sites [ion binding]; other site 484021002226 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 484021002227 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 484021002228 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 484021002229 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 484021002230 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 484021002231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484021002232 Walker A motif; other site 484021002233 ATP binding site [chemical binding]; other site 484021002234 Walker B motif; other site 484021002235 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 484021002236 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 484021002237 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 484021002238 tetrameric interface [polypeptide binding]; other site 484021002239 NAD binding site [chemical binding]; other site 484021002240 catalytic residues [active] 484021002241 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 484021002242 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021002243 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021002244 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021002245 putative active site [active] 484021002246 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021002247 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484021002248 substrate binding site [chemical binding]; other site 484021002249 ATP binding site [chemical binding]; other site 484021002250 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 484021002251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 484021002252 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 484021002253 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021002254 PYR/PP interface [polypeptide binding]; other site 484021002255 dimer interface [polypeptide binding]; other site 484021002256 TPP binding site [chemical binding]; other site 484021002257 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021002258 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 484021002259 TPP-binding site; other site 484021002260 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021002261 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021002262 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021002263 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 484021002264 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 484021002265 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 484021002266 Metal-binding active site; metal-binding site 484021002267 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 484021002268 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 484021002269 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 484021002270 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 484021002271 Walker A/P-loop; other site 484021002272 ATP binding site [chemical binding]; other site 484021002273 Q-loop/lid; other site 484021002274 ABC transporter signature motif; other site 484021002275 Walker B; other site 484021002276 D-loop; other site 484021002277 H-loop/switch region; other site 484021002278 TOBE domain; Region: TOBE_2; pfam08402 484021002279 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 484021002280 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 484021002281 active site 484021002282 metal binding site [ion binding]; metal-binding site 484021002283 hexamer interface [polypeptide binding]; other site 484021002284 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484021002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021002286 dimer interface [polypeptide binding]; other site 484021002287 conserved gate region; other site 484021002288 putative PBP binding loops; other site 484021002289 ABC-ATPase subunit interface; other site 484021002290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021002291 dimer interface [polypeptide binding]; other site 484021002292 conserved gate region; other site 484021002293 putative PBP binding loops; other site 484021002294 ABC-ATPase subunit interface; other site 484021002295 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 484021002296 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 484021002297 putative NAD(P) binding site [chemical binding]; other site 484021002298 putative substrate binding site [chemical binding]; other site 484021002299 catalytic Zn binding site [ion binding]; other site 484021002300 structural Zn binding site [ion binding]; other site 484021002301 dimer interface [polypeptide binding]; other site 484021002302 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484021002303 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 484021002304 Sulfate transporter family; Region: Sulfate_transp; pfam00916 484021002305 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484021002306 Sulfate transporter family; Region: Sulfate_transp; pfam00916 484021002307 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 484021002308 active site clefts [active] 484021002309 zinc binding site [ion binding]; other site 484021002310 dimer interface [polypeptide binding]; other site 484021002311 integrase; Provisional; Region: PRK09692 484021002312 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 484021002313 active site 484021002314 Int/Topo IB signature motif; other site 484021002315 Restriction endonuclease; Region: Mrr_cat; pfam04471 484021002316 Part of AAA domain; Region: AAA_19; pfam13245 484021002317 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 484021002318 Family description; Region: UvrD_C_2; pfam13538 484021002319 potential frameshift: common BLAST hit: gi|47104068|ref|YP_015497.1| putative exonuclease 484021002320 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 484021002321 putative active site [active] 484021002322 putative metal-binding site [ion binding]; other site 484021002323 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 484021002324 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 484021002325 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 484021002326 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 484021002327 Putative helicase; Region: TraI_2; pfam07514 484021002328 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021002329 Zn2+ binding site [ion binding]; other site 484021002330 Mg2+ binding site [ion binding]; other site 484021002331 Protein of unknown function (DUF1528); Region: DUF1528; pfam07515 484021002332 RES domain; Region: RES; pfam08808 484021002333 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 484021002334 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 484021002335 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 484021002336 integrating conjugative element protein, PFL_4711 family; Region: conj_TIGR03755 484021002337 integrating conjugative element protein, PFL_4710 family; Region: conj_TIGR03756 484021002338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484021002339 active site 484021002340 DNA binding site [nucleotide binding] 484021002341 Int/Topo IB signature motif; other site 484021002342 Fimbrial protein; Region: Fimbrial; cl01416 484021002343 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021002344 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021002345 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021002346 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021002347 PapC N-terminal domain; Region: PapC_N; pfam13954 484021002348 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021002349 PapC C-terminal domain; Region: PapC_C; pfam13953 484021002350 Fimbrial protein; Region: Fimbrial; cl01416 484021002351 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021002352 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021002353 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021002354 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 484021002355 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 484021002356 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 484021002357 Phosphotransferase system sorbitol-specific component IIA [Carbohydrate transport and metabolism]; Region: SrlB; COG3731 484021002358 Phosphotransferase system sorbitol-specific component IIC [Carbohydrate transport and metabolism]; Region: SrlA; COG3730 484021002359 Winged helix-turn-helix DNA-binding; Region: HTH_35; pfam13693 484021002360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021002361 non-specific DNA binding site [nucleotide binding]; other site 484021002362 salt bridge; other site 484021002363 sequence-specific DNA binding site [nucleotide binding]; other site 484021002364 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021002365 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021002366 non-specific DNA binding site [nucleotide binding]; other site 484021002367 salt bridge; other site 484021002368 sequence-specific DNA binding site [nucleotide binding]; other site 484021002369 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 484021002370 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 484021002371 putative active site [active] 484021002372 putative NTP binding site [chemical binding]; other site 484021002373 putative nucleic acid binding site [nucleotide binding]; other site 484021002374 conjugative transfer ATPase, PFL_4706 family; Region: traC_PFL_4706; TIGR03744 484021002375 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 484021002376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021002377 Walker A motif; other site 484021002378 ATP binding site [chemical binding]; other site 484021002379 conjugative transfer region lipoprotein, TIGR03751 family; Region: conj_TIGR03751 484021002380 integrating conjugative element protein, PFL_4705 family; Region: conj_TIGR03752 484021002381 Protein of unknown function (DUF3438); Region: DUF3438; pfam11920 484021002382 integrating conjugative element protein, PFL_4703 family; Region: conj_TIGR03746 484021002383 conjugative transfer region protein, TIGR03750 family; Region: conj_TIGR03750 484021002384 integrating conjugative element membrane protein, PFL_4702 family; Region: conj_TIGR03745 484021002385 Protein of unknown function (DUF3262); Region: DUF3262; cl13160 484021002386 Nuclease-related domain; Region: NERD; pfam08378 484021002387 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 484021002388 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 484021002389 substrate binding site [chemical binding]; other site 484021002390 activation loop (A-loop); other site 484021002391 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 484021002392 active site 484021002393 ATP binding site [chemical binding]; other site 484021002394 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 484021002395 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 484021002396 activation loop (A-loop); other site 484021002397 DNA helicase, putative; Region: TIGR00376 484021002398 Part of AAA domain; Region: AAA_19; pfam13245 484021002399 AAA domain; Region: AAA_12; pfam13087 484021002400 Domain of unknown function (DUF4400); Region: DUF4400; cl14023 484021002401 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 484021002402 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 484021002403 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 484021002404 integrating conjugative element protein, PFL_4693 family; Region: conj_TIGR03759 484021002405 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 484021002406 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 484021002407 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 484021002408 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 484021002409 putative dimer interface [polypeptide binding]; other site 484021002410 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 484021002411 active site 484021002412 putative metal-binding site [ion binding]; other site 484021002413 putative interdomain interaction site [polypeptide binding]; other site 484021002414 putative nucleotide binding site [chemical binding]; other site 484021002415 DNA topoisomerase; Region: Topoisom_bac; pfam01131 484021002416 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 484021002417 domain I; other site 484021002418 DNA binding groove [nucleotide binding] 484021002419 phosphate binding site [ion binding]; other site 484021002420 domain II; other site 484021002421 domain III; other site 484021002422 nucleotide binding site [chemical binding]; other site 484021002423 catalytic site [active] 484021002424 domain IV; other site 484021002425 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 484021002426 active site 484021002427 metal binding site [ion binding]; metal-binding site 484021002428 Protein of unknown function (DUF3158); Region: DUF3158; pfam11358 484021002429 Domain of unknown function (DUF1845); Region: DUF1845; cl07481 484021002430 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 484021002431 integrating conjugative element, PFGI_1 class, ParB family protein; Region: ICE_PFGI_1_parB; TIGR03764 484021002432 ParB-like nuclease domain; Region: ParBc; cl02129 484021002433 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 484021002434 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 484021002435 HNH endonuclease; Region: HNH_2; pfam13391 484021002436 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 484021002437 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 484021002438 cofactor binding site; other site 484021002439 DNA binding site [nucleotide binding] 484021002440 substrate interaction site [chemical binding]; other site 484021002441 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021002442 ATP binding site [chemical binding]; other site 484021002443 putative Mg++ binding site [ion binding]; other site 484021002444 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 484021002445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021002446 nucleotide binding region [chemical binding]; other site 484021002447 ATP-binding site [chemical binding]; other site 484021002448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021002449 ATP-binding site [chemical binding]; other site 484021002450 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 484021002451 Putative catalytic domain of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar4; cd09132 484021002452 PLD-like domain; Region: PLDc_2; pfam13091 484021002453 putative active site [active] 484021002454 putative catalytic site [active] 484021002455 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 484021002456 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021002457 Transposase; Region: HTH_Tnp_1; pfam01527 484021002458 PAAR motif; Region: PAAR_motif; pfam05488 484021002459 Transposase; Region: HTH_Tnp_1; pfam01527 484021002460 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 484021002461 Integrase core domain; Region: rve; pfam00665 484021002462 Integrase core domain; Region: rve_3; pfam13683 484021002463 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484021002464 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484021002465 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484021002466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484021002467 active site 484021002468 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 484021002469 MULE transposase domain; Region: MULE; pfam10551 484021002470 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 484021002471 active site 484021002472 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 484021002473 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 484021002474 inhibitor binding site; inhibition site 484021002475 active site 484021002476 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484021002477 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 484021002478 xylose isomerase; Provisional; Region: PRK05474 484021002479 xylose isomerase; Region: xylose_isom_A; TIGR02630 484021002480 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 484021002481 Protein of unknown function (DUF523); Region: DUF523; pfam04463 484021002482 Uncharacterized conserved protein [Function unknown]; Region: COG3272 484021002483 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 484021002484 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 484021002485 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 484021002486 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 484021002487 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021002488 S-adenosylmethionine binding site [chemical binding]; other site 484021002489 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 484021002490 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 484021002491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484021002492 short chain dehydrogenase; Provisional; Region: PRK06101 484021002493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021002494 NAD(P) binding site [chemical binding]; other site 484021002495 active site 484021002496 SnoaL-like domain; Region: SnoaL_2; pfam12680 484021002497 transcriptional regulator MirA; Provisional; Region: PRK15043 484021002498 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 484021002499 DNA binding residues [nucleotide binding] 484021002500 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 484021002501 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 484021002502 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 484021002503 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 484021002504 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 484021002505 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021002506 periplasmic copper-binding protein; Provisional; Region: PRK09838 484021002507 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 484021002508 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 484021002509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021002510 active site 484021002511 phosphorylation site [posttranslational modification] 484021002512 intermolecular recognition site; other site 484021002513 dimerization interface [polypeptide binding]; other site 484021002514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021002515 DNA binding site [nucleotide binding] 484021002516 sensor kinase CusS; Provisional; Region: PRK09835 484021002517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021002518 dimerization interface [polypeptide binding]; other site 484021002519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021002520 dimer interface [polypeptide binding]; other site 484021002521 phosphorylation site [posttranslational modification] 484021002522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021002523 ATP binding site [chemical binding]; other site 484021002524 Mg2+ binding site [ion binding]; other site 484021002525 G-X-G motif; other site 484021002526 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 484021002527 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021002528 Uncharacterized conserved protein [Function unknown]; Region: COG2850 484021002529 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 484021002530 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 484021002531 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484021002532 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484021002533 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484021002534 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 484021002535 Walker A/P-loop; other site 484021002536 ATP binding site [chemical binding]; other site 484021002537 Q-loop/lid; other site 484021002538 ABC transporter signature motif; other site 484021002539 Walker B; other site 484021002540 D-loop; other site 484021002541 H-loop/switch region; other site 484021002542 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484021002543 Walker A/P-loop; other site 484021002544 ATP binding site [chemical binding]; other site 484021002545 Q-loop/lid; other site 484021002546 ABC transporter signature motif; other site 484021002547 Walker B; other site 484021002548 D-loop; other site 484021002549 H-loop/switch region; other site 484021002550 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484021002551 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 484021002552 HlyD family secretion protein; Region: HlyD; pfam00529 484021002553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021002554 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021002555 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 484021002556 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 484021002557 active site 484021002558 HIGH motif; other site 484021002559 dimer interface [polypeptide binding]; other site 484021002560 KMSKS motif; other site 484021002561 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 484021002562 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 484021002563 ligand binding site [chemical binding]; other site 484021002564 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021002565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021002566 Walker A/P-loop; other site 484021002567 ATP binding site [chemical binding]; other site 484021002568 Q-loop/lid; other site 484021002569 ABC transporter signature motif; other site 484021002570 Walker B; other site 484021002571 D-loop; other site 484021002572 H-loop/switch region; other site 484021002573 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021002574 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021002575 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021002576 TM-ABC transporter signature motif; other site 484021002577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021002578 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021002579 TM-ABC transporter signature motif; other site 484021002580 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 484021002581 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484021002582 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021002583 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021002584 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 484021002585 putative substrate binding pocket [chemical binding]; other site 484021002586 putative dimerization interface [polypeptide binding]; other site 484021002587 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 484021002588 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 484021002589 dimer interface [polypeptide binding]; other site 484021002590 Mn binding site [ion binding]; other site 484021002591 K binding site [ion binding]; other site 484021002592 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021002593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021002594 DNA-binding site [nucleotide binding]; DNA binding site 484021002595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021002596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021002597 homodimer interface [polypeptide binding]; other site 484021002598 catalytic residue [active] 484021002599 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 484021002600 transcriptional regulator SlyA; Provisional; Region: PRK03573 484021002601 MarR family; Region: MarR_2; cl17246 484021002602 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484021002603 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021002604 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 484021002605 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 484021002606 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 484021002607 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 484021002608 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 484021002609 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 484021002610 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 484021002611 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 484021002612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021002613 putative substrate translocation pore; other site 484021002614 Protein of unknown function (DUF445); Region: DUF445; pfam04286 484021002615 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 484021002616 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021002617 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021002618 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002619 putative transposase; Provisional; Region: PRK09857 484021002620 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021002621 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 484021002622 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 484021002623 NAD(P) binding site [chemical binding]; other site 484021002624 catalytic residues [active] 484021002625 YfaZ precursor; Region: YfaZ; pfam07437 484021002626 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 484021002627 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 484021002628 P-loop, Walker A motif; other site 484021002629 Base recognition motif; other site 484021002630 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 484021002631 Uncharacterized small protein [Function unknown]; Region: COG2879 484021002632 carbon starvation protein A; Provisional; Region: PRK15015 484021002633 Carbon starvation protein CstA; Region: CstA; pfam02554 484021002634 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 484021002635 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 484021002636 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 484021002637 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 484021002638 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 484021002639 Cupin domain; Region: Cupin_2; pfam07883 484021002640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002641 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 484021002642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021002643 putative substrate translocation pore; other site 484021002644 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 484021002645 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 484021002646 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 484021002647 putative substrate binding pocket [chemical binding]; other site 484021002648 trimer interface [polypeptide binding]; other site 484021002649 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 484021002650 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 484021002651 putative active site [active] 484021002652 putative metal binding site [ion binding]; other site 484021002653 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 484021002654 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 484021002655 NAD binding site [chemical binding]; other site 484021002656 catalytic residues [active] 484021002657 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 484021002658 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 484021002659 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 484021002660 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021002661 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 484021002662 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 484021002663 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 484021002664 dimer interface [polypeptide binding]; other site 484021002665 active site 484021002666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484021002667 substrate binding site [chemical binding]; other site 484021002668 catalytic residue [active] 484021002669 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 484021002670 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 484021002671 active site 484021002672 putative substrate binding pocket [chemical binding]; other site 484021002673 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484021002674 homotrimer interaction site [polypeptide binding]; other site 484021002675 putative active site [active] 484021002676 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 484021002677 Na binding site [ion binding]; other site 484021002678 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 484021002679 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 484021002680 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 484021002681 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 484021002682 active site 484021002683 intersubunit interface [polypeptide binding]; other site 484021002684 catalytic residue [active] 484021002685 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021002686 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021002687 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021002688 putative active site [active] 484021002689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021002690 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021002691 Coenzyme A binding pocket [chemical binding]; other site 484021002692 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021002693 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 484021002694 Coenzyme A binding pocket [chemical binding]; other site 484021002695 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 484021002696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021002697 Walker A motif; other site 484021002698 ATP binding site [chemical binding]; other site 484021002699 Walker B motif; other site 484021002700 arginine finger; other site 484021002701 Transcriptional antiterminator [Transcription]; Region: COG3933 484021002702 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 484021002703 active pocket/dimerization site; other site 484021002704 active site 484021002705 phosphorylation site [posttranslational modification] 484021002706 PRD domain; Region: PRD; pfam00874 484021002707 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 484021002708 active pocket/dimerization site; other site 484021002709 active site 484021002710 phosphorylation site [posttranslational modification] 484021002711 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 484021002712 active site 484021002713 phosphorylation site [posttranslational modification] 484021002714 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 484021002715 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 484021002716 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 484021002717 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484021002718 dimer interface [polypeptide binding]; other site 484021002719 active site 484021002720 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484021002721 dimer interface [polypeptide binding]; other site 484021002722 active site 484021002723 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 484021002724 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 484021002725 putative active site [active] 484021002726 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 484021002727 putative transposase; Provisional; Region: PRK09857 484021002728 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021002729 phosphoglycerol transferase I; Provisional; Region: PRK03776 484021002730 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 484021002731 hypothetical protein; Provisional; Region: PRK11667 484021002732 DNA replication protein DnaC; Validated; Region: PRK07952 484021002733 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021002734 Walker A motif; other site 484021002735 ATP binding site [chemical binding]; other site 484021002736 Walker B motif; other site 484021002737 primosomal protein DnaI; Provisional; Region: PRK02854 484021002738 hypothetical protein; Provisional; Region: PRK09917 484021002739 Uncharacterized conserved protein [Function unknown]; Region: COG2966 484021002740 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 484021002741 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 484021002742 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484021002743 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 484021002744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002745 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021002746 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021002747 DNA binding residues [nucleotide binding] 484021002748 dimerization interface [polypeptide binding]; other site 484021002749 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 484021002750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021002751 DNA binding residues [nucleotide binding] 484021002752 dimerization interface [polypeptide binding]; other site 484021002753 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 484021002754 putative deacylase active site [active] 484021002755 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484021002756 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021002757 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 484021002758 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 484021002759 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 484021002760 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021002761 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021002762 metal binding site [ion binding]; metal-binding site 484021002763 active site 484021002764 I-site; other site 484021002765 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 484021002766 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 484021002767 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 484021002768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021002769 DNA polymerase III subunit psi; Validated; Region: PRK06856 484021002770 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 484021002771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021002772 Coenzyme A binding pocket [chemical binding]; other site 484021002773 dUMP phosphatase; Provisional; Region: PRK09449 484021002774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021002775 motif II; other site 484021002776 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 484021002777 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 484021002778 G1 box; other site 484021002779 putative GEF interaction site [polypeptide binding]; other site 484021002780 GTP/Mg2+ binding site [chemical binding]; other site 484021002781 Switch I region; other site 484021002782 G2 box; other site 484021002783 G3 box; other site 484021002784 Switch II region; other site 484021002785 G4 box; other site 484021002786 G5 box; other site 484021002787 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 484021002788 periplasmic protein; Provisional; Region: PRK10568 484021002789 BON domain; Region: BON; pfam04972 484021002790 BON domain; Region: BON; cl02771 484021002791 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 484021002792 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 484021002793 active site 484021002794 nucleophile elbow; other site 484021002795 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484021002796 active site 484021002797 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 484021002798 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484021002799 Nucleoside recognition; Region: Gate; pfam07670 484021002800 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484021002801 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 484021002802 intersubunit interface [polypeptide binding]; other site 484021002803 active site 484021002804 catalytic residue [active] 484021002805 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 484021002806 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 484021002807 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 484021002808 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 484021002809 phosphopentomutase; Provisional; Region: PRK05362 484021002810 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 484021002811 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 484021002812 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 484021002813 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 484021002814 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 484021002815 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 484021002816 hypothetical protein; Provisional; Region: PRK11246 484021002817 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 484021002818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021002819 motif II; other site 484021002820 DNA repair protein RadA; Region: sms; TIGR00416 484021002821 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 484021002822 Walker A motif/ATP binding site; other site 484021002823 ATP binding site [chemical binding]; other site 484021002824 Walker B motif; other site 484021002825 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 484021002826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021002827 non-specific DNA binding site [nucleotide binding]; other site 484021002828 salt bridge; other site 484021002829 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 484021002830 sequence-specific DNA binding site [nucleotide binding]; other site 484021002831 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 484021002832 active site 484021002833 (T/H)XGH motif; other site 484021002834 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 484021002835 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 484021002836 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021002837 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021002838 ABC transporter; Region: ABC_tran_2; pfam12848 484021002839 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021002840 lytic murein transglycosylase; Provisional; Region: PRK11619 484021002841 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021002842 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021002843 catalytic residue [active] 484021002844 Trp operon repressor; Provisional; Region: PRK01381 484021002845 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 484021002846 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484021002847 catalytic core [active] 484021002848 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 484021002849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021002850 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 484021002851 hypothetical protein; Provisional; Region: PRK10756 484021002852 CreA protein; Region: CreA; pfam05981 484021002853 DNA-binding response regulator CreB; Provisional; Region: PRK11083 484021002854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021002855 active site 484021002856 phosphorylation site [posttranslational modification] 484021002857 intermolecular recognition site; other site 484021002858 dimerization interface [polypeptide binding]; other site 484021002859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021002860 DNA binding site [nucleotide binding] 484021002861 sensory histidine kinase CreC; Provisional; Region: PRK11100 484021002862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021002863 dimer interface [polypeptide binding]; other site 484021002864 phosphorylation site [posttranslational modification] 484021002865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021002866 ATP binding site [chemical binding]; other site 484021002867 Mg2+ binding site [ion binding]; other site 484021002868 G-X-G motif; other site 484021002869 Inner membrane protein CreD; Region: CreD; pfam06123 484021002870 two-component response regulator; Provisional; Region: PRK11173 484021002871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021002872 active site 484021002873 phosphorylation site [posttranslational modification] 484021002874 intermolecular recognition site; other site 484021002875 dimerization interface [polypeptide binding]; other site 484021002876 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021002877 DNA binding site [nucleotide binding] 484021002878 putative RNA methyltransferase; Provisional; Region: PRK10433 484021002879 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 484021002880 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 484021002881 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 484021002882 putative catalytic residues [active] 484021002883 putative nucleotide binding site [chemical binding]; other site 484021002884 putative aspartate binding site [chemical binding]; other site 484021002885 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 484021002886 dimer interface [polypeptide binding]; other site 484021002887 putative threonine allosteric regulatory site; other site 484021002888 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 484021002889 putative threonine allosteric regulatory site; other site 484021002890 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 484021002891 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 484021002892 homoserine kinase; Provisional; Region: PRK01212 484021002893 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484021002894 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 484021002895 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 484021002896 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 484021002897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021002898 catalytic residue [active] 484021002899 hypothetical protein; Validated; Region: PRK02101 484021002900 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 484021002901 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 484021002902 transaldolase-like protein; Provisional; Region: PTZ00411 484021002903 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 484021002904 active site 484021002905 dimer interface [polypeptide binding]; other site 484021002906 catalytic residue [active] 484021002907 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 484021002908 MPT binding site; other site 484021002909 trimer interface [polypeptide binding]; other site 484021002910 metabolite-proton symporter; Region: 2A0106; TIGR00883 484021002911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021002912 putative substrate translocation pore; other site 484021002913 hypothetical protein; Provisional; Region: PRK10659 484021002914 hypothetical protein; Provisional; Region: PRK10236 484021002915 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 484021002916 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 484021002917 hypothetical protein; Provisional; Region: PRK10154 484021002918 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 484021002919 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484021002920 nucleotide binding site [chemical binding]; other site 484021002921 chaperone protein DnaJ; Provisional; Region: PRK10767 484021002922 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484021002923 HSP70 interaction site [polypeptide binding]; other site 484021002924 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 484021002925 substrate binding site [polypeptide binding]; other site 484021002926 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 484021002927 Zn binding sites [ion binding]; other site 484021002928 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 484021002929 dimer interface [polypeptide binding]; other site 484021002930 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 484021002931 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 484021002932 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021002933 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 484021002934 putative dimerization interface [polypeptide binding]; other site 484021002935 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 484021002936 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 484021002937 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 484021002938 active site 484021002939 Riboflavin kinase; Region: Flavokinase; smart00904 484021002940 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 484021002941 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 484021002942 HIGH motif; other site 484021002943 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 484021002944 active site 484021002945 KMSKS motif; other site 484021002946 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 484021002947 tRNA binding surface [nucleotide binding]; other site 484021002948 anticodon binding site; other site 484021002949 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484021002950 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 484021002951 lipoprotein signal peptidase; Provisional; Region: PRK14787 484021002952 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 484021002953 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484021002954 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 484021002955 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 484021002956 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 484021002957 active site 484021002958 tetramer interface [polypeptide binding]; other site 484021002959 Protein of unknown function (DUF805); Region: DUF805; pfam05656 484021002960 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021002961 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021002962 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021002963 putative effector binding pocket; other site 484021002964 dimerization interface [polypeptide binding]; other site 484021002965 alanine-tRNA ligase; Region: PLN02961 484021002966 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 484021002967 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 484021002968 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 484021002969 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 484021002970 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 484021002971 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 484021002972 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 484021002973 catalytic site [active] 484021002974 subunit interface [polypeptide binding]; other site 484021002975 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 484021002976 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484021002977 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 484021002978 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 484021002979 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484021002980 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484021002981 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 484021002982 IMP binding site; other site 484021002983 dimer interface [polypeptide binding]; other site 484021002984 interdomain contacts; other site 484021002985 partial ornithine binding site; other site 484021002986 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 484021002987 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 484021002988 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 484021002989 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 484021002990 TrkA-N domain; Region: TrkA_N; pfam02254 484021002991 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 484021002992 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 484021002993 folate binding site [chemical binding]; other site 484021002994 NADP+ binding site [chemical binding]; other site 484021002995 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 484021002996 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 484021002997 active site 484021002998 metal binding site [ion binding]; metal-binding site 484021002999 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 484021003000 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 484021003001 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 484021003002 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 484021003003 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 484021003004 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 484021003005 SurA N-terminal domain; Region: SurA_N; pfam09312 484021003006 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 484021003007 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 484021003008 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 484021003009 OstA-like protein; Region: OstA; pfam03968 484021003010 Organic solvent tolerance protein; Region: OstA_C; pfam04453 484021003011 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 484021003012 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 484021003013 putative metal binding site [ion binding]; other site 484021003014 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484021003015 HSP70 interaction site [polypeptide binding]; other site 484021003016 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 484021003017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021003018 active site 484021003019 phosphorylation site [posttranslational modification] 484021003020 intermolecular recognition site; other site 484021003021 dimerization interface [polypeptide binding]; other site 484021003022 Transcriptional regulator; Region: CitT; pfam12431 484021003023 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 484021003024 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 484021003025 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021003026 putative active site [active] 484021003027 heme pocket [chemical binding]; other site 484021003028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021003029 ATP binding site [chemical binding]; other site 484021003030 Mg2+ binding site [ion binding]; other site 484021003031 G-X-G motif; other site 484021003032 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 484021003033 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 484021003034 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 484021003035 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484021003036 active site 484021003037 ATP-dependent helicase HepA; Validated; Region: PRK04914 484021003038 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021003039 ATP binding site [chemical binding]; other site 484021003040 putative Mg++ binding site [ion binding]; other site 484021003041 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021003042 nucleotide binding region [chemical binding]; other site 484021003043 ATP-binding site [chemical binding]; other site 484021003044 DNA polymerase II; Reviewed; Region: PRK05762 484021003045 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 484021003046 active site 484021003047 catalytic site [active] 484021003048 substrate binding site [chemical binding]; other site 484021003049 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 484021003050 active site 484021003051 metal-binding site 484021003052 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 484021003053 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 484021003054 intersubunit interface [polypeptide binding]; other site 484021003055 active site 484021003056 Zn2+ binding site [ion binding]; other site 484021003057 L-arabinose isomerase; Provisional; Region: PRK02929 484021003058 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 484021003059 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 484021003060 trimer interface [polypeptide binding]; other site 484021003061 putative substrate binding site [chemical binding]; other site 484021003062 putative metal binding site [ion binding]; other site 484021003063 ribulokinase; Provisional; Region: PRK04123 484021003064 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 484021003065 N- and C-terminal domain interface [polypeptide binding]; other site 484021003066 active site 484021003067 MgATP binding site [chemical binding]; other site 484021003068 catalytic site [active] 484021003069 metal binding site [ion binding]; metal-binding site 484021003070 carbohydrate binding site [chemical binding]; other site 484021003071 homodimer interface [polypeptide binding]; other site 484021003072 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 484021003073 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021003074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021003075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021003076 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484021003077 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484021003078 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 484021003079 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 484021003080 Walker A/P-loop; other site 484021003081 ATP binding site [chemical binding]; other site 484021003082 Q-loop/lid; other site 484021003083 ABC transporter signature motif; other site 484021003084 Walker B; other site 484021003085 D-loop; other site 484021003086 H-loop/switch region; other site 484021003087 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 484021003088 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003089 dimer interface [polypeptide binding]; other site 484021003090 conserved gate region; other site 484021003091 putative PBP binding loops; other site 484021003092 ABC-ATPase subunit interface; other site 484021003093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003094 dimer interface [polypeptide binding]; other site 484021003095 conserved gate region; other site 484021003096 putative PBP binding loops; other site 484021003097 ABC-ATPase subunit interface; other site 484021003098 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 484021003099 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 484021003100 transcriptional regulator SgrR; Provisional; Region: PRK13626 484021003101 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 484021003102 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 484021003103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021003104 sugar efflux transporter; Region: 2A0120; TIGR00899 484021003105 putative substrate translocation pore; other site 484021003106 D-galactonate transporter; Region: 2A0114; TIGR00893 484021003107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021003108 putative substrate translocation pore; other site 484021003109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021003110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021003111 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 484021003112 putative dimerization interface [polypeptide binding]; other site 484021003113 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 484021003114 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 484021003115 active site 484021003116 catalytic residue [active] 484021003117 dimer interface [polypeptide binding]; other site 484021003118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021003119 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021003120 putative substrate translocation pore; other site 484021003121 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 484021003122 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484021003123 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484021003124 shikimate binding site; other site 484021003125 NAD(P) binding site [chemical binding]; other site 484021003126 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 484021003127 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 484021003128 active site 484021003129 FMN binding site [chemical binding]; other site 484021003130 substrate binding site [chemical binding]; other site 484021003131 putative catalytic residue [active] 484021003132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 484021003133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021003134 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 484021003135 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 484021003136 substrate binding site [chemical binding]; other site 484021003137 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 484021003138 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 484021003139 substrate binding site [chemical binding]; other site 484021003140 ligand binding site [chemical binding]; other site 484021003141 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 484021003142 tartrate dehydrogenase; Region: TTC; TIGR02089 484021003143 2-isopropylmalate synthase; Validated; Region: PRK00915 484021003144 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 484021003145 active site 484021003146 catalytic residues [active] 484021003147 metal binding site [ion binding]; metal-binding site 484021003148 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 484021003149 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 484021003150 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021003151 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 484021003152 putative substrate binding pocket [chemical binding]; other site 484021003153 putative dimerization interface [polypeptide binding]; other site 484021003154 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 484021003155 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021003156 PYR/PP interface [polypeptide binding]; other site 484021003157 dimer interface [polypeptide binding]; other site 484021003158 TPP binding site [chemical binding]; other site 484021003159 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021003160 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 484021003161 TPP-binding site [chemical binding]; other site 484021003162 dimer interface [polypeptide binding]; other site 484021003163 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 484021003164 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 484021003165 putative valine binding site [chemical binding]; other site 484021003166 dimer interface [polypeptide binding]; other site 484021003167 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 484021003168 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 484021003169 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021003170 DNA binding site [nucleotide binding] 484021003171 domain linker motif; other site 484021003172 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 484021003173 dimerization interface [polypeptide binding]; other site 484021003174 ligand binding site [chemical binding]; other site 484021003175 mraZ protein; Region: TIGR00242 484021003176 MraZ protein; Region: MraZ; pfam02381 484021003177 MraZ protein; Region: MraZ; pfam02381 484021003178 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 484021003179 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 484021003180 cell division protein FtsL; Provisional; Region: PRK10772 484021003181 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 484021003182 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484021003183 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484021003184 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 484021003185 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484021003186 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484021003187 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484021003188 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 484021003189 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484021003190 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484021003191 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484021003192 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 484021003193 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 484021003194 Mg++ binding site [ion binding]; other site 484021003195 putative catalytic motif [active] 484021003196 putative substrate binding site [chemical binding]; other site 484021003197 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 484021003198 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484021003199 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484021003200 cell division protein FtsW; Provisional; Region: PRK10774 484021003201 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 484021003202 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 484021003203 active site 484021003204 homodimer interface [polypeptide binding]; other site 484021003205 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 484021003206 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484021003207 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484021003208 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484021003209 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 484021003210 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 484021003211 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 484021003212 cell division protein FtsQ; Provisional; Region: PRK10775 484021003213 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 484021003214 Cell division protein FtsQ; Region: FtsQ; pfam03799 484021003215 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 484021003216 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021003217 Cell division protein FtsA; Region: FtsA; pfam14450 484021003218 cell division protein FtsZ; Validated; Region: PRK09330 484021003219 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 484021003220 nucleotide binding site [chemical binding]; other site 484021003221 SulA interaction site; other site 484021003222 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 484021003223 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 484021003224 SecA regulator SecM; Provisional; Region: PRK02943 484021003225 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 484021003226 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 484021003227 SEC-C motif; Region: SEC-C; pfam02810 484021003228 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 484021003229 active site 484021003230 8-oxo-dGMP binding site [chemical binding]; other site 484021003231 nudix motif; other site 484021003232 metal binding site [ion binding]; metal-binding site 484021003233 DNA gyrase inhibitor; Reviewed; Region: PRK00418 484021003234 hypothetical protein; Provisional; Region: PRK05287 484021003235 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 484021003236 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 484021003237 CoA-binding site [chemical binding]; other site 484021003238 ATP-binding [chemical binding]; other site 484021003239 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 484021003240 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 484021003241 active site 484021003242 type IV pilin biogenesis protein; Provisional; Region: PRK10573 484021003243 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 484021003244 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 484021003245 hypothetical protein; Provisional; Region: PRK10436 484021003246 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 484021003247 Walker A motif; other site 484021003248 ATP binding site [chemical binding]; other site 484021003249 Walker B motif; other site 484021003250 putative major pilin subunit; Provisional; Region: PRK10574 484021003251 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 484021003252 Pilin (bacterial filament); Region: Pilin; pfam00114 484021003253 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 484021003254 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 484021003255 dimerization interface [polypeptide binding]; other site 484021003256 active site 484021003257 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 484021003258 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 484021003259 amidase catalytic site [active] 484021003260 Zn binding residues [ion binding]; other site 484021003261 substrate binding site [chemical binding]; other site 484021003262 regulatory protein AmpE; Provisional; Region: PRK10987 484021003263 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 484021003264 active site 484021003265 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484021003266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021003267 putative substrate translocation pore; other site 484021003268 aromatic amino acid transporter; Provisional; Region: PRK10238 484021003269 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 484021003270 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021003271 DNA-binding site [nucleotide binding]; DNA binding site 484021003272 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 484021003273 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 484021003274 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 484021003275 dimer interface [polypeptide binding]; other site 484021003276 TPP-binding site [chemical binding]; other site 484021003277 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 484021003278 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484021003279 E3 interaction surface; other site 484021003280 lipoyl attachment site [posttranslational modification]; other site 484021003281 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484021003282 E3 interaction surface; other site 484021003283 lipoyl attachment site [posttranslational modification]; other site 484021003284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484021003285 E3 interaction surface; other site 484021003286 lipoyl attachment site [posttranslational modification]; other site 484021003287 e3 binding domain; Region: E3_binding; pfam02817 484021003288 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 484021003289 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 484021003290 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021003291 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021003292 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484021003293 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 484021003294 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 484021003295 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 484021003296 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 484021003297 substrate binding site [chemical binding]; other site 484021003298 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 484021003299 substrate binding site [chemical binding]; other site 484021003300 ligand binding site [chemical binding]; other site 484021003301 hypothetical protein; Provisional; Region: PRK05248 484021003302 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 484021003303 spermidine synthase; Provisional; Region: PRK00811 484021003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021003305 S-adenosylmethionine binding site [chemical binding]; other site 484021003306 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484021003307 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 484021003308 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484021003309 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 484021003310 multicopper oxidase; Provisional; Region: PRK10965 484021003311 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 484021003312 Multicopper oxidase; Region: Cu-oxidase; pfam00394 484021003313 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 484021003314 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 484021003315 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 484021003316 Trp docking motif [polypeptide binding]; other site 484021003317 putative active site [active] 484021003318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021003319 active site 484021003320 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 484021003321 active site clefts [active] 484021003322 zinc binding site [ion binding]; other site 484021003323 dimer interface [polypeptide binding]; other site 484021003324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484021003325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484021003326 Walker A/P-loop; other site 484021003327 ATP binding site [chemical binding]; other site 484021003328 Q-loop/lid; other site 484021003329 ABC transporter signature motif; other site 484021003330 Walker B; other site 484021003331 D-loop; other site 484021003332 H-loop/switch region; other site 484021003333 inner membrane transport permease; Provisional; Region: PRK15066 484021003334 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484021003335 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 484021003336 active pocket/dimerization site; other site 484021003337 active site 484021003338 phosphorylation site [posttranslational modification] 484021003339 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 484021003340 putative active site [active] 484021003341 putative metal binding site [ion binding]; other site 484021003342 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 484021003343 tetramerization interface [polypeptide binding]; other site 484021003344 active site 484021003345 pantoate--beta-alanine ligase; Region: panC; TIGR00018 484021003346 Pantoate-beta-alanine ligase; Region: PanC; cd00560 484021003347 active site 484021003348 ATP-binding site [chemical binding]; other site 484021003349 pantoate-binding site; other site 484021003350 HXXH motif; other site 484021003351 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 484021003352 oligomerization interface [polypeptide binding]; other site 484021003353 active site 484021003354 metal binding site [ion binding]; metal-binding site 484021003355 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 484021003356 catalytic center binding site [active] 484021003357 ATP binding site [chemical binding]; other site 484021003358 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 484021003359 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 484021003360 active site 484021003361 NTP binding site [chemical binding]; other site 484021003362 metal binding triad [ion binding]; metal-binding site 484021003363 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 484021003364 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 484021003365 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 484021003366 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 484021003367 active site 484021003368 nucleotide binding site [chemical binding]; other site 484021003369 HIGH motif; other site 484021003370 KMSKS motif; other site 484021003371 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 484021003372 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 484021003373 2'-5' RNA ligase; Provisional; Region: PRK15124 484021003374 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 484021003375 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 484021003376 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 484021003377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021003378 ATP binding site [chemical binding]; other site 484021003379 putative Mg++ binding site [ion binding]; other site 484021003380 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021003381 nucleotide binding region [chemical binding]; other site 484021003382 ATP-binding site [chemical binding]; other site 484021003383 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 484021003384 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 484021003385 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 484021003386 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 484021003387 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 484021003388 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 484021003389 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 484021003390 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 484021003391 GspL periplasmic domain; Region: GspL_C; pfam12693 484021003392 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 484021003393 type II secretion system protein J; Region: gspJ; TIGR01711 484021003394 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 484021003395 type II secretion system protein I; Region: gspI; TIGR01707 484021003396 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 484021003397 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 484021003398 type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708 484021003399 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 484021003400 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 484021003401 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 484021003402 type II secretion system protein F; Region: GspF; TIGR02120 484021003403 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 484021003404 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 484021003405 type II secretion system protein E; Region: type_II_gspE; TIGR02533 484021003406 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 484021003407 Walker A motif; other site 484021003408 ATP binding site [chemical binding]; other site 484021003409 Walker B motif; other site 484021003410 type II secretion system protein D; Region: type_II_gspD; TIGR02517 484021003411 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 484021003412 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 484021003413 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 484021003414 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 484021003415 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 484021003416 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 484021003417 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 484021003418 carbohydrate binding site [chemical binding]; other site 484021003419 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 484021003420 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 484021003421 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 484021003422 Ca binding site [ion binding]; other site 484021003423 active site 484021003424 catalytic site [active] 484021003425 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 484021003426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021003427 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021003428 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021003429 putative transposase OrfB; Reviewed; Region: PHA02517 484021003430 HTH-like domain; Region: HTH_21; pfam13276 484021003431 Integrase core domain; Region: rve; pfam00665 484021003432 Integrase core domain; Region: rve_2; pfam13333 484021003433 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 484021003434 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 484021003435 Transglycosylase; Region: Transgly; pfam00912 484021003436 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 484021003437 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 484021003438 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021003439 N-terminal plug; other site 484021003440 ligand-binding site [chemical binding]; other site 484021003441 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 484021003442 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021003443 Walker A/P-loop; other site 484021003444 ATP binding site [chemical binding]; other site 484021003445 Q-loop/lid; other site 484021003446 ABC transporter signature motif; other site 484021003447 Walker B; other site 484021003448 D-loop; other site 484021003449 H-loop/switch region; other site 484021003450 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 484021003451 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 484021003452 siderophore binding site; other site 484021003453 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021003454 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021003455 ABC-ATPase subunit interface; other site 484021003456 dimer interface [polypeptide binding]; other site 484021003457 putative PBP binding regions; other site 484021003458 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021003459 ABC-ATPase subunit interface; other site 484021003460 dimer interface [polypeptide binding]; other site 484021003461 putative PBP binding regions; other site 484021003462 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 484021003463 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021003464 inhibitor-cofactor binding pocket; inhibition site 484021003465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021003466 catalytic residue [active] 484021003467 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 484021003468 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 484021003469 Cl- selectivity filter; other site 484021003470 Cl- binding residues [ion binding]; other site 484021003471 pore gating glutamate residue; other site 484021003472 dimer interface [polypeptide binding]; other site 484021003473 H+/Cl- coupling transport residue; other site 484021003474 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 484021003475 hypothetical protein; Provisional; Region: PRK10578 484021003476 UPF0126 domain; Region: UPF0126; pfam03458 484021003477 UPF0126 domain; Region: UPF0126; pfam03458 484021003478 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 484021003479 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 484021003480 cobalamin binding residues [chemical binding]; other site 484021003481 putative BtuC binding residues; other site 484021003482 dimer interface [polypeptide binding]; other site 484021003483 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 484021003484 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 484021003485 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 484021003486 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021003487 Zn2+ binding site [ion binding]; other site 484021003488 Mg2+ binding site [ion binding]; other site 484021003489 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 484021003490 serine endoprotease; Provisional; Region: PRK10942 484021003491 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 484021003492 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 484021003493 protein binding site [polypeptide binding]; other site 484021003494 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 484021003495 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 484021003496 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 484021003497 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 484021003498 hypothetical protein; Provisional; Region: PRK13677 484021003499 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 484021003500 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 484021003501 trimer interface [polypeptide binding]; other site 484021003502 active site 484021003503 substrate binding site [chemical binding]; other site 484021003504 CoA binding site [chemical binding]; other site 484021003505 PII uridylyl-transferase; Provisional; Region: PRK05007 484021003506 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 484021003507 metal binding triad; other site 484021003508 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 484021003509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021003510 Zn2+ binding site [ion binding]; other site 484021003511 Mg2+ binding site [ion binding]; other site 484021003512 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 484021003513 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 484021003514 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 484021003515 active site 484021003516 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 484021003517 rRNA interaction site [nucleotide binding]; other site 484021003518 S8 interaction site; other site 484021003519 putative laminin-1 binding site; other site 484021003520 elongation factor Ts; Provisional; Region: tsf; PRK09377 484021003521 UBA/TS-N domain; Region: UBA; pfam00627 484021003522 Elongation factor TS; Region: EF_TS; pfam00889 484021003523 Elongation factor TS; Region: EF_TS; pfam00889 484021003524 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 484021003525 putative nucleotide binding site [chemical binding]; other site 484021003526 uridine monophosphate binding site [chemical binding]; other site 484021003527 homohexameric interface [polypeptide binding]; other site 484021003528 ribosome recycling factor; Reviewed; Region: frr; PRK00083 484021003529 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 484021003530 hinge region; other site 484021003531 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 484021003532 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 484021003533 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 484021003534 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 484021003535 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 484021003536 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 484021003537 catalytic residue [active] 484021003538 putative FPP diphosphate binding site; other site 484021003539 putative FPP binding hydrophobic cleft; other site 484021003540 dimer interface [polypeptide binding]; other site 484021003541 putative IPP diphosphate binding site; other site 484021003542 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 484021003543 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 484021003544 zinc metallopeptidase RseP; Provisional; Region: PRK10779 484021003545 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 484021003546 active site 484021003547 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 484021003548 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 484021003549 protein binding site [polypeptide binding]; other site 484021003550 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 484021003551 putative substrate binding region [chemical binding]; other site 484021003552 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 484021003553 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021003554 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021003555 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021003556 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021003557 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 484021003558 Surface antigen; Region: Bac_surface_Ag; pfam01103 484021003559 periplasmic chaperone; Provisional; Region: PRK10780 484021003560 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 484021003561 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 484021003562 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 484021003563 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 484021003564 trimer interface [polypeptide binding]; other site 484021003565 active site 484021003566 UDP-GlcNAc binding site [chemical binding]; other site 484021003567 lipid binding site [chemical binding]; lipid-binding site 484021003568 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 484021003569 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 484021003570 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 484021003571 active site 484021003572 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 484021003573 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 484021003574 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 484021003575 RNA/DNA hybrid binding site [nucleotide binding]; other site 484021003576 active site 484021003577 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 484021003578 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 484021003579 putative active site [active] 484021003580 putative PHP Thumb interface [polypeptide binding]; other site 484021003581 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 484021003582 generic binding surface II; other site 484021003583 generic binding surface I; other site 484021003584 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 484021003585 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 484021003586 lysine decarboxylase LdcC; Provisional; Region: PRK15399 484021003587 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 484021003588 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 484021003589 homodimer interface [polypeptide binding]; other site 484021003590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021003591 catalytic residue [active] 484021003592 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 484021003593 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 484021003594 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021003595 putative metal binding site [ion binding]; other site 484021003596 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 484021003597 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 484021003598 Ligand Binding Site [chemical binding]; other site 484021003599 TilS substrate binding domain; Region: TilS; pfam09179 484021003600 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 484021003601 Rho-binding antiterminator; Provisional; Region: PRK11625 484021003602 hypothetical protein; Provisional; Region: PRK04964 484021003603 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 484021003604 hypothetical protein; Provisional; Region: PRK09256 484021003605 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 484021003606 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 484021003607 NlpE N-terminal domain; Region: NlpE; pfam04170 484021003608 hypothetical protein; Provisional; Region: PRK11479 484021003609 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 484021003610 prolyl-tRNA synthetase; Provisional; Region: PRK09194 484021003611 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 484021003612 dimer interface [polypeptide binding]; other site 484021003613 motif 1; other site 484021003614 active site 484021003615 motif 2; other site 484021003616 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 484021003617 putative deacylase active site [active] 484021003618 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484021003619 active site 484021003620 motif 3; other site 484021003621 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 484021003622 anticodon binding site; other site 484021003623 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 484021003624 homodimer interaction site [polypeptide binding]; other site 484021003625 cofactor binding site; other site 484021003626 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 484021003627 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 484021003628 lipoprotein, YaeC family; Region: TIGR00363 484021003629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003630 dimer interface [polypeptide binding]; other site 484021003631 conserved gate region; other site 484021003632 ABC-ATPase subunit interface; other site 484021003633 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 484021003634 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 484021003635 Walker A/P-loop; other site 484021003636 ATP binding site [chemical binding]; other site 484021003637 Q-loop/lid; other site 484021003638 ABC transporter signature motif; other site 484021003639 Walker B; other site 484021003640 D-loop; other site 484021003641 H-loop/switch region; other site 484021003642 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 484021003643 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 484021003644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021003645 active site 484021003646 motif I; other site 484021003647 motif II; other site 484021003648 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021003649 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021003650 active site 484021003651 catalytic tetrad [active] 484021003652 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021003653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021003654 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 484021003655 putative effector binding pocket; other site 484021003656 dimerization interface [polypeptide binding]; other site 484021003657 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021003658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021003659 putative substrate translocation pore; other site 484021003660 hypothetical protein; Provisional; Region: PRK05421 484021003661 putative catalytic site [active] 484021003662 putative metal binding site [ion binding]; other site 484021003663 putative phosphate binding site [ion binding]; other site 484021003664 putative catalytic site [active] 484021003665 putative phosphate binding site [ion binding]; other site 484021003666 putative metal binding site [ion binding]; other site 484021003667 Methyltransferase domain; Region: Methyltransf_31; pfam13847 484021003668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021003669 S-adenosylmethionine binding site [chemical binding]; other site 484021003670 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 484021003671 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021003672 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021003673 catalytic residue [active] 484021003674 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021003675 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021003676 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 484021003677 Methyltransferase domain; Region: Methyltransf_11; pfam08241 484021003678 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 484021003679 RNA/DNA hybrid binding site [nucleotide binding]; other site 484021003680 active site 484021003681 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 484021003682 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 484021003683 active site 484021003684 catalytic site [active] 484021003685 substrate binding site [chemical binding]; other site 484021003686 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021003687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021003688 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021003689 dimerization interface [polypeptide binding]; other site 484021003690 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 484021003691 C-N hydrolase family amidase; Provisional; Region: PRK10438 484021003692 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 484021003693 putative active site [active] 484021003694 catalytic triad [active] 484021003695 dimer interface [polypeptide binding]; other site 484021003696 multimer interface [polypeptide binding]; other site 484021003697 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 484021003698 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 484021003699 active site 484021003700 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 484021003701 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 484021003702 dimer interface [polypeptide binding]; other site 484021003703 active site 484021003704 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 484021003705 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 484021003706 putative active site [active] 484021003707 putative dimer interface [polypeptide binding]; other site 484021003708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 484021003709 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 484021003710 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484021003711 E3 interaction surface; other site 484021003712 lipoyl attachment site [posttranslational modification]; other site 484021003713 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 484021003714 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 484021003715 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 484021003716 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 484021003717 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 484021003718 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 484021003719 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 484021003720 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021003721 catalytic loop [active] 484021003722 iron binding site [ion binding]; other site 484021003723 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 484021003724 FAD binding pocket [chemical binding]; other site 484021003725 FAD binding motif [chemical binding]; other site 484021003726 phosphate binding motif [ion binding]; other site 484021003727 beta-alpha-beta structure motif; other site 484021003728 NAD binding pocket [chemical binding]; other site 484021003729 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 484021003730 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 484021003731 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 484021003732 active site 484021003733 catalytic site [active] 484021003734 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 484021003735 active site 484021003736 DNA polymerase IV; Validated; Region: PRK02406 484021003737 DNA binding site [nucleotide binding] 484021003738 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021003739 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021003740 Coenzyme A binding pocket [chemical binding]; other site 484021003741 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 484021003742 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 484021003743 metal binding site [ion binding]; metal-binding site 484021003744 dimer interface [polypeptide binding]; other site 484021003745 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021003746 active site 484021003747 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 484021003748 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 484021003749 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 484021003750 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021003751 DNA-binding site [nucleotide binding]; DNA binding site 484021003752 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 484021003753 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 484021003754 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 484021003755 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021003756 inhibitor-cofactor binding pocket; inhibition site 484021003757 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021003758 catalytic residue [active] 484021003759 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 484021003760 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 484021003761 tetramerization interface [polypeptide binding]; other site 484021003762 NAD(P) binding site [chemical binding]; other site 484021003763 catalytic residues [active] 484021003764 Predicted dehydrogenase [General function prediction only]; Region: COG0579 484021003765 hydroxyglutarate oxidase; Provisional; Region: PRK11728 484021003766 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 484021003767 substrate binding pocket [chemical binding]; other site 484021003768 active site 484021003769 iron coordination sites [ion binding]; other site 484021003770 hypothetical protein; Provisional; Region: PRK13687 484021003771 Methyltransferase domain; Region: Methyltransf_31; pfam13847 484021003772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021003773 S-adenosylmethionine binding site [chemical binding]; other site 484021003774 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484021003775 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 484021003776 putative C-terminal domain interface [polypeptide binding]; other site 484021003777 putative GSH binding site (G-site) [chemical binding]; other site 484021003778 putative dimer interface [polypeptide binding]; other site 484021003779 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 484021003780 putative N-terminal domain interface [polypeptide binding]; other site 484021003781 putative dimer interface [polypeptide binding]; other site 484021003782 putative substrate binding pocket (H-site) [chemical binding]; other site 484021003783 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 484021003784 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 484021003785 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 484021003786 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 484021003787 putative ligand binding site [chemical binding]; other site 484021003788 putative NAD binding site [chemical binding]; other site 484021003789 catalytic site [active] 484021003790 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484021003791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021003792 NAD(P) binding site [chemical binding]; other site 484021003793 active site 484021003794 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 484021003795 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 484021003796 putative N- and C-terminal domain interface [polypeptide binding]; other site 484021003797 putative active site [active] 484021003798 MgATP binding site [chemical binding]; other site 484021003799 catalytic site [active] 484021003800 metal binding site [ion binding]; metal-binding site 484021003801 putative xylulose binding site [chemical binding]; other site 484021003802 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 484021003803 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 484021003804 Class I aldolases; Region: Aldolase_Class_I; cl17187 484021003805 catalytic residue [active] 484021003806 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 484021003807 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 484021003808 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 484021003809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021003810 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484021003811 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484021003812 E3 interaction surface; other site 484021003813 lipoyl attachment site [posttranslational modification]; other site 484021003814 e3 binding domain; Region: E3_binding; pfam02817 484021003815 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 484021003816 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 484021003817 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 484021003818 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 484021003819 alpha subunit interface [polypeptide binding]; other site 484021003820 TPP binding site [chemical binding]; other site 484021003821 heterodimer interface [polypeptide binding]; other site 484021003822 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021003823 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 484021003824 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 484021003825 tetramer interface [polypeptide binding]; other site 484021003826 TPP-binding site [chemical binding]; other site 484021003827 heterodimer interface [polypeptide binding]; other site 484021003828 phosphorylation loop region [posttranslational modification] 484021003829 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 484021003830 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021003831 DNA binding residues [nucleotide binding] 484021003832 dimerization interface [polypeptide binding]; other site 484021003833 HTH-like domain; Region: HTH_21; pfam13276 484021003834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 484021003835 Integrase core domain; Region: rve; pfam00665 484021003836 Integrase core domain; Region: rve_3; pfam13683 484021003837 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 484021003838 DNA-binding interface [nucleotide binding]; DNA binding site 484021003839 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 484021003840 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 484021003841 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 484021003842 putative catalytic cysteine [active] 484021003843 gamma-glutamyl kinase; Provisional; Region: PRK05429 484021003844 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 484021003845 nucleotide binding site [chemical binding]; other site 484021003846 homotetrameric interface [polypeptide binding]; other site 484021003847 putative phosphate binding site [ion binding]; other site 484021003848 putative allosteric binding site; other site 484021003849 PUA domain; Region: PUA; pfam01472 484021003850 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 484021003851 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 484021003852 trimer interface [polypeptide binding]; other site 484021003853 eyelet of channel; other site 484021003854 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 484021003855 NlpC/P60 family; Region: NLPC_P60; pfam00877 484021003856 EamA-like transporter family; Region: EamA; pfam00892 484021003857 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 484021003858 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484021003859 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 484021003860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 484021003861 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 484021003862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003863 dimer interface [polypeptide binding]; other site 484021003864 conserved gate region; other site 484021003865 putative PBP binding loops; other site 484021003866 ABC-ATPase subunit interface; other site 484021003867 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 484021003868 Transferrin; Region: Transferrin; cl02460 484021003869 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 484021003870 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 484021003871 Walker A/P-loop; other site 484021003872 ATP binding site [chemical binding]; other site 484021003873 Q-loop/lid; other site 484021003874 ABC transporter signature motif; other site 484021003875 Walker B; other site 484021003876 D-loop; other site 484021003877 H-loop/switch region; other site 484021003878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021003879 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021003880 DNA binding residues [nucleotide binding] 484021003881 putative fimbrial protein TcfA; Provisional; Region: PRK15308 484021003882 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021003883 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 484021003884 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021003885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003886 dimer interface [polypeptide binding]; other site 484021003887 conserved gate region; other site 484021003888 putative PBP binding loops; other site 484021003889 ABC-ATPase subunit interface; other site 484021003890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003891 dimer interface [polypeptide binding]; other site 484021003892 conserved gate region; other site 484021003893 putative PBP binding loops; other site 484021003894 ABC-ATPase subunit interface; other site 484021003895 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021003896 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021003897 Walker A/P-loop; other site 484021003898 ATP binding site [chemical binding]; other site 484021003899 Q-loop/lid; other site 484021003900 ABC transporter signature motif; other site 484021003901 Walker B; other site 484021003902 D-loop; other site 484021003903 H-loop/switch region; other site 484021003904 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021003905 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021003906 substrate binding pocket [chemical binding]; other site 484021003907 membrane-bound complex binding site; other site 484021003908 hinge residues; other site 484021003909 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 484021003910 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 484021003911 Walker A/P-loop; other site 484021003912 ATP binding site [chemical binding]; other site 484021003913 Q-loop/lid; other site 484021003914 ABC transporter signature motif; other site 484021003915 Walker B; other site 484021003916 D-loop; other site 484021003917 H-loop/switch region; other site 484021003918 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 484021003919 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 484021003920 Walker A/P-loop; other site 484021003921 ATP binding site [chemical binding]; other site 484021003922 Q-loop/lid; other site 484021003923 ABC transporter signature motif; other site 484021003924 Walker B; other site 484021003925 D-loop; other site 484021003926 H-loop/switch region; other site 484021003927 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 484021003928 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 484021003929 TM-ABC transporter signature motif; other site 484021003930 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021003931 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 484021003932 TM-ABC transporter signature motif; other site 484021003933 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 484021003934 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 484021003935 putative ligand binding site [chemical binding]; other site 484021003936 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 484021003937 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 484021003938 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 484021003939 ethanolamine permease; Region: 2A0305; TIGR00908 484021003940 S-methylmethionine transporter; Provisional; Region: PRK11387 484021003941 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 484021003942 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 484021003943 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 484021003944 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021003945 substrate binding pocket [chemical binding]; other site 484021003946 membrane-bound complex binding site; other site 484021003947 hinge residues; other site 484021003948 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 484021003949 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484021003950 Walker A/P-loop; other site 484021003951 ATP binding site [chemical binding]; other site 484021003952 Q-loop/lid; other site 484021003953 ABC transporter signature motif; other site 484021003954 Walker B; other site 484021003955 D-loop; other site 484021003956 H-loop/switch region; other site 484021003957 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484021003958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021003959 dimer interface [polypeptide binding]; other site 484021003960 conserved gate region; other site 484021003961 putative PBP binding loops; other site 484021003962 ABC-ATPase subunit interface; other site 484021003963 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 484021003964 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 484021003965 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 484021003966 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484021003967 putative acyl-acceptor binding pocket; other site 484021003968 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 484021003969 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 484021003970 dimer interface [polypeptide binding]; other site 484021003971 active site 484021003972 Schiff base residues; other site 484021003973 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 484021003974 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 484021003975 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 484021003976 Isochorismatase family; Region: Isochorismatase; pfam00857 484021003977 catalytic triad [active] 484021003978 conserved cis-peptide bond; other site 484021003979 microcin B17 transporter; Reviewed; Region: PRK11098 484021003980 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 484021003981 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 484021003982 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 484021003983 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 484021003984 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 484021003985 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 484021003986 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 484021003987 drug efflux system protein MdtG; Provisional; Region: PRK09874 484021003988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021003989 putative substrate translocation pore; other site 484021003990 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 484021003991 alkaline phosphatase; Provisional; Region: PRK10518 484021003992 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 484021003993 active site 484021003994 dimer interface [polypeptide binding]; other site 484021003995 hypothetical protein; Provisional; Region: PRK11505 484021003996 psiF repeat; Region: PsiF_repeat; pfam07769 484021003997 psiF repeat; Region: PsiF_repeat; pfam07769 484021003998 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 484021003999 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 484021004000 hypothetical protein; Validated; Region: PRK00124 484021004001 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 484021004002 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 484021004003 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 484021004004 ADP binding site [chemical binding]; other site 484021004005 magnesium binding site [ion binding]; other site 484021004006 putative shikimate binding site; other site 484021004007 hypothetical protein; Provisional; Region: PRK10380 484021004008 hypothetical protein; Provisional; Region: PRK10481 484021004009 hypothetical protein; Provisional; Region: PRK10579 484021004010 recombination associated protein; Reviewed; Region: rdgC; PRK00321 484021004011 fructokinase; Reviewed; Region: PRK09557 484021004012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021004013 nucleotide binding site [chemical binding]; other site 484021004014 Acetokinase family; Region: Acetate_kinase; cl17229 484021004015 exonuclease subunit SbcC; Provisional; Region: PRK10246 484021004016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021004017 Walker A/P-loop; other site 484021004018 ATP binding site [chemical binding]; other site 484021004019 Q-loop/lid; other site 484021004020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021004021 ABC transporter signature motif; other site 484021004022 Walker B; other site 484021004023 D-loop; other site 484021004024 H-loop/switch region; other site 484021004025 exonuclease subunit SbcD; Provisional; Region: PRK10966 484021004026 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 484021004027 active site 484021004028 metal binding site [ion binding]; metal-binding site 484021004029 DNA binding site [nucleotide binding] 484021004030 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 484021004031 transcriptional regulator PhoB; Provisional; Region: PRK10161 484021004032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021004033 active site 484021004034 phosphorylation site [posttranslational modification] 484021004035 intermolecular recognition site; other site 484021004036 dimerization interface [polypeptide binding]; other site 484021004037 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021004038 DNA binding site [nucleotide binding] 484021004039 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 484021004040 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 484021004041 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021004042 putative active site [active] 484021004043 heme pocket [chemical binding]; other site 484021004044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021004045 dimer interface [polypeptide binding]; other site 484021004046 phosphorylation site [posttranslational modification] 484021004047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021004048 ATP binding site [chemical binding]; other site 484021004049 Mg2+ binding site [ion binding]; other site 484021004050 G-X-G motif; other site 484021004051 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 484021004052 putative proline-specific permease; Provisional; Region: proY; PRK10580 484021004053 maltodextrin glucosidase; Provisional; Region: PRK10785 484021004054 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 484021004055 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 484021004056 active site 484021004057 homodimer interface [polypeptide binding]; other site 484021004058 catalytic site [active] 484021004059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021004060 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 484021004061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021004062 dimerization interface [polypeptide binding]; other site 484021004063 Isochorismatase family; Region: Isochorismatase; pfam00857 484021004064 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 484021004065 catalytic triad [active] 484021004066 dimer interface [polypeptide binding]; other site 484021004067 conserved cis-peptide bond; other site 484021004068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 484021004069 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 484021004070 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 484021004071 active site 484021004072 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 484021004073 intersubunit interface [polypeptide binding]; other site 484021004074 active site 484021004075 zinc binding site [ion binding]; other site 484021004076 Na+ binding site [ion binding]; other site 484021004077 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021004078 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 484021004079 substrate binding site [chemical binding]; other site 484021004080 ATP binding site [chemical binding]; other site 484021004081 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 484021004082 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 484021004083 active site 484021004084 P-loop; other site 484021004085 phosphorylation site [posttranslational modification] 484021004086 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021004087 active site 484021004088 phosphorylation site [posttranslational modification] 484021004089 peroxidase; Provisional; Region: PRK15000 484021004090 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 484021004091 dimer interface [polypeptide binding]; other site 484021004092 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484021004093 catalytic triad [active] 484021004094 peroxidatic and resolving cysteines [active] 484021004095 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 484021004096 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 484021004097 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 484021004098 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 484021004099 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 484021004100 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 484021004101 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 484021004102 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 484021004103 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 484021004104 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 484021004105 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 484021004106 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 484021004107 Protein export membrane protein; Region: SecD_SecF; pfam02355 484021004108 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 484021004109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021004110 Predicted transcriptional regulator [Transcription]; Region: COG2378 484021004111 HTH domain; Region: HTH_11; pfam08279 484021004112 WYL domain; Region: WYL; pfam13280 484021004113 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 484021004114 hypothetical protein; Provisional; Region: PRK11530 484021004115 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 484021004116 ATP cone domain; Region: ATP-cone; pfam03477 484021004117 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 484021004118 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 484021004119 catalytic motif [active] 484021004120 Zn binding site [ion binding]; other site 484021004121 RibD C-terminal domain; Region: RibD_C; cl17279 484021004122 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 484021004123 homopentamer interface [polypeptide binding]; other site 484021004124 active site 484021004125 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 484021004126 putative RNA binding site [nucleotide binding]; other site 484021004127 thiamine monophosphate kinase; Provisional; Region: PRK05731 484021004128 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 484021004129 ATP binding site [chemical binding]; other site 484021004130 dimerization interface [polypeptide binding]; other site 484021004131 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 484021004132 tetramer interfaces [polypeptide binding]; other site 484021004133 binuclear metal-binding site [ion binding]; other site 484021004134 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021004135 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021004136 active site 484021004137 catalytic tetrad [active] 484021004138 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 484021004139 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 484021004140 TPP-binding site; other site 484021004141 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484021004142 PYR/PP interface [polypeptide binding]; other site 484021004143 dimer interface [polypeptide binding]; other site 484021004144 TPP binding site [chemical binding]; other site 484021004145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021004146 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 484021004147 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484021004148 substrate binding pocket [chemical binding]; other site 484021004149 chain length determination region; other site 484021004150 substrate-Mg2+ binding site; other site 484021004151 catalytic residues [active] 484021004152 aspartate-rich region 1; other site 484021004153 active site lid residues [active] 484021004154 aspartate-rich region 2; other site 484021004155 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 484021004156 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 484021004157 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 484021004158 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 484021004159 Ligand Binding Site [chemical binding]; other site 484021004160 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484021004161 active site residue [active] 484021004162 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 484021004163 putative hydrophobic ligand binding site [chemical binding]; other site 484021004164 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 484021004165 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 484021004166 conserved cys residue [active] 484021004167 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 484021004168 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 484021004169 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 484021004170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 484021004171 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 484021004172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021004174 putative substrate translocation pore; other site 484021004175 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021004176 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021004177 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021004178 benzoate transport; Region: 2A0115; TIGR00895 484021004179 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004180 putative substrate translocation pore; other site 484021004181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004182 putative substrate translocation pore; other site 484021004183 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 484021004184 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 484021004185 Predicted oxidoreductase [General function prediction only]; Region: COG3573 484021004186 NIPSNAP; Region: NIPSNAP; pfam07978 484021004187 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 484021004188 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 484021004189 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 484021004190 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484021004191 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484021004192 shikimate binding site; other site 484021004193 NAD(P) binding site [chemical binding]; other site 484021004194 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 484021004195 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021004196 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021004197 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 484021004198 UbiA prenyltransferase family; Region: UbiA; pfam01040 484021004199 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 484021004200 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 484021004201 Subunit I/III interface [polypeptide binding]; other site 484021004202 Subunit III/IV interface [polypeptide binding]; other site 484021004203 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 484021004204 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 484021004205 D-pathway; other site 484021004206 Putative ubiquinol binding site [chemical binding]; other site 484021004207 Low-spin heme (heme b) binding site [chemical binding]; other site 484021004208 Putative water exit pathway; other site 484021004209 Binuclear center (heme o3/CuB) [ion binding]; other site 484021004210 K-pathway; other site 484021004211 Putative proton exit pathway; other site 484021004212 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 484021004213 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 484021004214 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 484021004215 muropeptide transporter; Reviewed; Region: ampG; PRK11902 484021004216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004217 putative substrate translocation pore; other site 484021004218 hypothetical protein; Provisional; Region: PRK11627 484021004219 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 484021004220 BolA-like protein; Region: BolA; cl00386 484021004221 trigger factor; Provisional; Region: tig; PRK01490 484021004222 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484021004223 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 484021004224 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 484021004225 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 484021004226 oligomer interface [polypeptide binding]; other site 484021004227 active site residues [active] 484021004228 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 484021004229 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 484021004230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021004231 Walker A motif; other site 484021004232 ATP binding site [chemical binding]; other site 484021004233 Walker B motif; other site 484021004234 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 484021004235 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 484021004236 Found in ATP-dependent protease La (LON); Region: LON; smart00464 484021004237 Found in ATP-dependent protease La (LON); Region: LON; smart00464 484021004238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021004239 Walker A motif; other site 484021004240 ATP binding site [chemical binding]; other site 484021004241 Walker B motif; other site 484021004242 arginine finger; other site 484021004243 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 484021004244 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 484021004245 IHF dimer interface [polypeptide binding]; other site 484021004246 IHF - DNA interface [nucleotide binding]; other site 484021004247 periplasmic folding chaperone; Provisional; Region: PRK10788 484021004248 SurA N-terminal domain; Region: SurA_N_3; cl07813 484021004249 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 484021004250 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 484021004251 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 484021004252 active site 484021004253 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 484021004254 Ligand Binding Site [chemical binding]; other site 484021004255 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 484021004256 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 484021004257 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 484021004258 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 484021004259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021004260 active site 484021004261 motif I; other site 484021004262 motif II; other site 484021004263 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484021004264 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484021004265 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 484021004266 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021004267 catalytic residue [active] 484021004268 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 484021004269 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021004270 putative DNA binding site [nucleotide binding]; other site 484021004271 putative Zn2+ binding site [ion binding]; other site 484021004272 AsnC family; Region: AsnC_trans_reg; pfam01037 484021004273 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 484021004274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021004275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021004276 Walker A/P-loop; other site 484021004277 ATP binding site [chemical binding]; other site 484021004278 Q-loop/lid; other site 484021004279 ABC transporter signature motif; other site 484021004280 Walker B; other site 484021004281 D-loop; other site 484021004282 H-loop/switch region; other site 484021004283 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 484021004284 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021004285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021004286 Walker A/P-loop; other site 484021004287 ATP binding site [chemical binding]; other site 484021004288 Q-loop/lid; other site 484021004289 ABC transporter signature motif; other site 484021004290 Walker B; other site 484021004291 D-loop; other site 484021004292 H-loop/switch region; other site 484021004293 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 484021004294 Nitrogen regulatory protein P-II; Region: P-II; smart00938 484021004295 ammonium transporter; Provisional; Region: PRK10666 484021004296 acyl-CoA thioesterase II; Provisional; Region: PRK10526 484021004297 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 484021004298 active site 484021004299 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 484021004300 catalytic triad [active] 484021004301 dimer interface [polypeptide binding]; other site 484021004302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 484021004303 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 484021004304 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484021004305 DNA binding site [nucleotide binding] 484021004306 active site 484021004307 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021004308 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021004309 DNA-binding site [nucleotide binding]; DNA binding site 484021004310 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021004311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021004312 homodimer interface [polypeptide binding]; other site 484021004313 catalytic residue [active] 484021004314 Predicted membrane protein [Function unknown]; Region: COG2364 484021004315 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 484021004316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 484021004317 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 484021004318 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 484021004319 putative metal binding site [ion binding]; other site 484021004320 putative homodimer interface [polypeptide binding]; other site 484021004321 putative homotetramer interface [polypeptide binding]; other site 484021004322 putative homodimer-homodimer interface [polypeptide binding]; other site 484021004323 putative allosteric switch controlling residues; other site 484021004324 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 484021004325 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 484021004326 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021004327 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 484021004328 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 484021004329 Walker A/P-loop; other site 484021004330 ATP binding site [chemical binding]; other site 484021004331 Q-loop/lid; other site 484021004332 ABC transporter signature motif; other site 484021004333 Walker B; other site 484021004334 D-loop; other site 484021004335 H-loop/switch region; other site 484021004336 TOBE domain; Region: TOBE_2; pfam08402 484021004337 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 484021004338 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 484021004339 DAK2 domain; Region: Dak2; cl03685 484021004340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004341 dimer interface [polypeptide binding]; other site 484021004342 conserved gate region; other site 484021004343 ABC-ATPase subunit interface; other site 484021004344 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484021004345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004346 dimer interface [polypeptide binding]; other site 484021004347 conserved gate region; other site 484021004348 putative PBP binding loops; other site 484021004349 ABC-ATPase subunit interface; other site 484021004350 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 484021004351 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 484021004352 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 484021004353 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 484021004354 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 484021004355 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021004356 active site turn [active] 484021004357 phosphorylation site [posttranslational modification] 484021004358 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 484021004359 trimer interface; other site 484021004360 sugar binding site [chemical binding]; other site 484021004361 lac repressor; Reviewed; Region: lacI; PRK09526 484021004362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021004363 DNA binding site [nucleotide binding] 484021004364 domain linker motif; other site 484021004365 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 484021004366 ligand binding site [chemical binding]; other site 484021004367 dimerization interface (open form) [polypeptide binding]; other site 484021004368 dimerization interface (closed form) [polypeptide binding]; other site 484021004369 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 484021004370 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 484021004371 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484021004372 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484021004373 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021004374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021004375 DNA-binding site [nucleotide binding]; DNA binding site 484021004376 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021004377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021004378 homodimer interface [polypeptide binding]; other site 484021004379 catalytic residue [active] 484021004380 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 484021004381 maltose O-acetyltransferase; Provisional; Region: PRK10092 484021004382 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 484021004383 active site 484021004384 substrate binding site [chemical binding]; other site 484021004385 trimer interface [polypeptide binding]; other site 484021004386 CoA binding site [chemical binding]; other site 484021004387 gene expression modulator; Provisional; Region: PRK10945 484021004388 Hha toxicity attenuator; Provisional; Region: PRK10667 484021004389 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 484021004390 Protein export membrane protein; Region: SecD_SecF; cl14618 484021004391 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 484021004392 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021004393 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 484021004394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021004395 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 484021004396 hypothetical protein; Provisional; Region: PRK11281 484021004397 M domain of GW182; Region: M_domain; pfam12938 484021004398 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 484021004399 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 484021004400 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021004401 putative transposase; Provisional; Region: PRK09857 484021004402 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021004403 hypothetical protein; Provisional; Region: PRK11038 484021004404 primosomal replication protein N''; Provisional; Region: PRK10093 484021004405 hypothetical protein; Provisional; Region: PRK10527 484021004406 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021004407 active site 484021004408 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 484021004409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021004410 Walker A motif; other site 484021004411 ATP binding site [chemical binding]; other site 484021004412 Walker B motif; other site 484021004413 arginine finger; other site 484021004414 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 484021004415 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 484021004416 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 484021004417 hypothetical protein; Validated; Region: PRK00153 484021004418 recombination protein RecR; Reviewed; Region: recR; PRK00076 484021004419 RecR protein; Region: RecR; pfam02132 484021004420 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 484021004421 putative active site [active] 484021004422 putative metal-binding site [ion binding]; other site 484021004423 tetramer interface [polypeptide binding]; other site 484021004424 heat shock protein 90; Provisional; Region: PRK05218 484021004425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021004426 ATP binding site [chemical binding]; other site 484021004427 Mg2+ binding site [ion binding]; other site 484021004428 G-X-G motif; other site 484021004429 adenylate kinase; Reviewed; Region: adk; PRK00279 484021004430 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 484021004431 AMP-binding site [chemical binding]; other site 484021004432 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 484021004433 ferrochelatase; Reviewed; Region: hemH; PRK00035 484021004434 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 484021004435 C-terminal domain interface [polypeptide binding]; other site 484021004436 active site 484021004437 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 484021004438 active site 484021004439 N-terminal domain interface [polypeptide binding]; other site 484021004440 inosine/guanosine kinase; Provisional; Region: PRK15074 484021004441 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021004442 putative cation:proton antiport protein; Provisional; Region: PRK10669 484021004443 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 484021004444 TrkA-N domain; Region: TrkA_N; pfam02254 484021004445 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004446 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021004447 putative substrate translocation pore; other site 484021004448 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 484021004449 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 484021004450 active site 484021004451 metal binding site [ion binding]; metal-binding site 484021004452 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 484021004453 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 484021004454 putative deacylase active site [active] 484021004455 TraB family; Region: TraB; cl12050 484021004456 copper exporting ATPase; Provisional; Region: copA; PRK10671 484021004457 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 484021004458 metal-binding site [ion binding] 484021004459 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 484021004460 metal-binding site [ion binding] 484021004461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021004462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021004463 motif II; other site 484021004464 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 484021004465 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 484021004466 DNA binding residues [nucleotide binding] 484021004467 dimer interface [polypeptide binding]; other site 484021004468 copper binding site [ion binding]; other site 484021004469 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 484021004470 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 484021004471 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 484021004472 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 484021004473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021004474 Walker A/P-loop; other site 484021004475 ATP binding site [chemical binding]; other site 484021004476 Q-loop/lid; other site 484021004477 ABC transporter signature motif; other site 484021004478 Walker B; other site 484021004479 D-loop; other site 484021004480 H-loop/switch region; other site 484021004481 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 484021004482 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 484021004483 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 484021004484 oxidoreductase; Provisional; Region: PRK08017 484021004485 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 484021004486 NADP binding site [chemical binding]; other site 484021004487 active site 484021004488 steroid binding site; other site 484021004489 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 484021004490 active site 484021004491 catalytic triad [active] 484021004492 oxyanion hole [active] 484021004493 switch loop; other site 484021004494 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 484021004495 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484021004496 Walker A/P-loop; other site 484021004497 ATP binding site [chemical binding]; other site 484021004498 Q-loop/lid; other site 484021004499 ABC transporter signature motif; other site 484021004500 Walker B; other site 484021004501 D-loop; other site 484021004502 H-loop/switch region; other site 484021004503 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 484021004504 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 484021004505 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 484021004506 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 484021004507 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 484021004508 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 484021004509 active site residue [active] 484021004510 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 484021004511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021004512 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021004513 dimerization interface [polypeptide binding]; other site 484021004514 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 484021004515 ureidoglycolate hydrolase; Provisional; Region: PRK03606 484021004516 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 484021004517 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021004518 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021004519 glyoxylate carboligase; Provisional; Region: PRK11269 484021004520 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021004521 PYR/PP interface [polypeptide binding]; other site 484021004522 dimer interface [polypeptide binding]; other site 484021004523 TPP binding site [chemical binding]; other site 484021004524 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021004525 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 484021004526 TPP-binding site [chemical binding]; other site 484021004527 hydroxypyruvate isomerase; Provisional; Region: PRK09997 484021004528 tartronate semialdehyde reductase; Provisional; Region: PRK15059 484021004529 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 484021004530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004531 D-galactonate transporter; Region: 2A0114; TIGR00893 484021004532 putative substrate translocation pore; other site 484021004533 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 484021004534 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 484021004535 Na binding site [ion binding]; other site 484021004536 putative substrate binding site [chemical binding]; other site 484021004537 allantoinase; Provisional; Region: PRK08044 484021004538 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 484021004539 active site 484021004540 putative uracil/xanthine transporter; Provisional; Region: PRK11412 484021004541 glycerate kinase II; Provisional; Region: PRK09932 484021004542 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 484021004543 Mif2/CENP-C like; Region: Mif2; pfam11699 484021004544 Cupin domain; Region: Cupin_2; pfam07883 484021004545 allantoate amidohydrolase; Region: AllC; TIGR03176 484021004546 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 484021004547 active site 484021004548 metal binding site [ion binding]; metal-binding site 484021004549 dimer interface [polypeptide binding]; other site 484021004550 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 484021004551 membrane protein FdrA; Validated; Region: PRK06091 484021004552 CoA binding domain; Region: CoA_binding; pfam02629 484021004553 CoA-ligase; Region: Ligase_CoA; pfam00549 484021004554 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 484021004555 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 484021004556 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 484021004557 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 484021004558 putative substrate binding site [chemical binding]; other site 484021004559 nucleotide binding site [chemical binding]; other site 484021004560 nucleotide binding site [chemical binding]; other site 484021004561 homodimer interface [polypeptide binding]; other site 484021004562 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 484021004563 ATP-grasp domain; Region: ATP-grasp; pfam02222 484021004564 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 484021004565 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 484021004566 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 484021004567 putative active site [active] 484021004568 putative metal binding site [ion binding]; other site 484021004569 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 484021004570 substrate binding site [chemical binding]; other site 484021004571 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 484021004572 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484021004573 active site 484021004574 HIGH motif; other site 484021004575 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484021004576 KMSKS motif; other site 484021004577 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 484021004578 tRNA binding surface [nucleotide binding]; other site 484021004579 anticodon binding site; other site 484021004580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4727 484021004581 Uncharacterized protein conserved in bacteria (DUF2145); Region: DUF2145; pfam09916 484021004582 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 484021004583 ribosome-associated protein; Provisional; Region: PRK11507 484021004584 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 484021004585 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 484021004586 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 484021004587 homodimer interface [polypeptide binding]; other site 484021004588 NADP binding site [chemical binding]; other site 484021004589 substrate binding site [chemical binding]; other site 484021004590 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 484021004591 active site 484021004592 homotetramer interface [polypeptide binding]; other site 484021004593 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 484021004594 dimer interface [polypeptide binding]; other site 484021004595 Citrate synthase; Region: Citrate_synt; pfam00285 484021004596 active site 484021004597 citrylCoA binding site [chemical binding]; other site 484021004598 NADH binding [chemical binding]; other site 484021004599 cationic pore residues; other site 484021004600 oxalacetate/citrate binding site [chemical binding]; other site 484021004601 coenzyme A binding site [chemical binding]; other site 484021004602 catalytic triad [active] 484021004603 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 484021004604 DNA binding residues [nucleotide binding] 484021004605 dimerization interface [polypeptide binding]; other site 484021004606 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021004607 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021004608 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021004609 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021004610 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021004611 PapC N-terminal domain; Region: PapC_N; pfam13954 484021004612 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021004613 PapC C-terminal domain; Region: PapC_C; pfam13953 484021004614 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021004615 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021004616 Coenzyme A binding pocket [chemical binding]; other site 484021004617 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 484021004618 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484021004619 putative acyl-acceptor binding pocket; other site 484021004620 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021004621 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 484021004622 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021004623 DNA binding site [nucleotide binding] 484021004624 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 484021004625 lysine decarboxylase CadA; Provisional; Region: PRK15400 484021004626 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 484021004627 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 484021004628 homodimer interface [polypeptide binding]; other site 484021004629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021004630 catalytic residue [active] 484021004631 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 484021004632 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484021004633 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004634 putative substrate translocation pore; other site 484021004635 POT family; Region: PTR2; pfam00854 484021004636 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 484021004637 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 484021004638 dimer interface [polypeptide binding]; other site 484021004639 putative anticodon binding site; other site 484021004640 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 484021004641 motif 1; other site 484021004642 active site 484021004643 motif 2; other site 484021004644 motif 3; other site 484021004645 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 484021004646 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 484021004647 Metal-binding active site; metal-binding site 484021004648 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021004649 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021004650 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021004651 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021004652 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021004653 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021004654 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021004655 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 484021004656 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021004657 DNA binding site [nucleotide binding] 484021004658 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 484021004659 putative ligand binding site [chemical binding]; other site 484021004660 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 484021004661 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 484021004662 putative ligand binding site [chemical binding]; other site 484021004663 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021004664 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021004665 Walker A/P-loop; other site 484021004666 ATP binding site [chemical binding]; other site 484021004667 Q-loop/lid; other site 484021004668 ABC transporter signature motif; other site 484021004669 Walker B; other site 484021004670 D-loop; other site 484021004671 H-loop/switch region; other site 484021004672 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021004673 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021004674 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021004675 TM-ABC transporter signature motif; other site 484021004676 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 484021004677 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021004678 DNA binding site [nucleotide binding] 484021004679 domain linker motif; other site 484021004680 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 484021004681 dimerization interface [polypeptide binding]; other site 484021004682 ligand binding site [chemical binding]; other site 484021004683 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 484021004684 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 484021004685 substrate binding [chemical binding]; other site 484021004686 active site 484021004687 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 484021004688 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 484021004689 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021004690 active site turn [active] 484021004691 phosphorylation site [posttranslational modification] 484021004692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021004693 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 484021004694 trimer interface; other site 484021004695 sugar binding site [chemical binding]; other site 484021004696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021004697 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 484021004698 putative substrate binding site [chemical binding]; other site 484021004699 putative ATP binding site [chemical binding]; other site 484021004700 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 484021004701 Transcriptional regulator; Region: Rrf2; cl17282 484021004702 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 484021004703 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 484021004704 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021004705 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021004706 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 484021004707 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021004708 Walker A/P-loop; other site 484021004709 ATP binding site [chemical binding]; other site 484021004710 Q-loop/lid; other site 484021004711 ABC transporter signature motif; other site 484021004712 Walker B; other site 484021004713 D-loop; other site 484021004714 H-loop/switch region; other site 484021004715 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021004716 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021004717 ABC-ATPase subunit interface; other site 484021004718 dimer interface [polypeptide binding]; other site 484021004719 putative PBP binding regions; other site 484021004720 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 484021004721 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 484021004722 intersubunit interface [polypeptide binding]; other site 484021004723 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 484021004724 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484021004725 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 484021004726 metal binding site [ion binding]; metal-binding site 484021004727 putative dimer interface [polypeptide binding]; other site 484021004728 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 484021004729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021004730 substrate binding pocket [chemical binding]; other site 484021004731 membrane-bound complex binding site; other site 484021004732 hinge residues; other site 484021004733 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021004734 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021004735 active site 484021004736 catalytic tetrad [active] 484021004737 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 484021004738 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484021004739 classical (c) SDRs; Region: SDR_c; cd05233 484021004740 NAD(P) binding site [chemical binding]; other site 484021004741 active site 484021004742 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 484021004743 Sulfatase; Region: Sulfatase; pfam00884 484021004744 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 484021004745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021004746 FeS/SAM binding site; other site 484021004747 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 484021004748 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021004749 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021004750 DNA binding residues [nucleotide binding] 484021004751 dimerization interface [polypeptide binding]; other site 484021004752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004753 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 484021004754 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 484021004755 active site 484021004756 Zn binding site [ion binding]; other site 484021004757 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 484021004758 Amino acid permease; Region: AA_permease_2; pfam13520 484021004759 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 484021004760 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 484021004761 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 484021004762 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484021004763 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484021004764 NAD(P) binding site [chemical binding]; other site 484021004765 catalytic residues [active] 484021004766 PQQ-like domain; Region: PQQ_2; pfam13360 484021004767 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 484021004768 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021004769 N-terminal plug; other site 484021004770 ligand-binding site [chemical binding]; other site 484021004771 phenylalanine transporter; Provisional; Region: PRK10249 484021004772 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 484021004773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004774 putative substrate translocation pore; other site 484021004775 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 484021004776 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 484021004777 Metal-binding active site; metal-binding site 484021004778 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 484021004779 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021004780 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021004781 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021004782 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021004783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021004784 DNA binding site [nucleotide binding] 484021004785 domain linker motif; other site 484021004786 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 484021004787 dimerization interface [polypeptide binding]; other site 484021004788 ligand binding site [chemical binding]; other site 484021004789 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484021004790 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021004791 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484021004792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021004793 putative substrate translocation pore; other site 484021004794 Helix-turn-helix domain; Region: HTH_31; pfam13560 484021004795 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 484021004796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021004797 ATP binding site [chemical binding]; other site 484021004798 Walker B motif; other site 484021004799 arginine finger; other site 484021004800 Transcriptional antiterminator [Transcription]; Region: COG3933 484021004801 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 484021004802 active pocket/dimerization site; other site 484021004803 active site 484021004804 phosphorylation site [posttranslational modification] 484021004805 PRD domain; Region: PRD; pfam00874 484021004806 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 484021004807 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 484021004808 putative active site [active] 484021004809 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484021004810 dimer interface [polypeptide binding]; other site 484021004811 active site 484021004812 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 484021004813 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484021004814 dimer interface [polypeptide binding]; other site 484021004815 active site 484021004816 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484021004817 dimer interface [polypeptide binding]; other site 484021004818 active site 484021004819 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 484021004820 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 484021004821 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 484021004822 active site 484021004823 phosphorylation site [posttranslational modification] 484021004824 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 484021004825 active site 484021004826 active pocket/dimerization site; other site 484021004827 phosphorylation site [posttranslational modification] 484021004828 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 484021004829 dimer interface [polypeptide binding]; other site 484021004830 FMN binding site [chemical binding]; other site 484021004831 hypothetical protein; Provisional; Region: PRK10250 484021004832 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021004833 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021004834 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 484021004835 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 484021004836 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 484021004837 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021004838 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 484021004839 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 484021004840 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 484021004841 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021004842 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 484021004843 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 484021004844 Soluble P-type ATPase [General function prediction only]; Region: COG4087 484021004845 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484021004846 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484021004847 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021004848 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021004849 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 484021004850 Predicted periplasmic protein [Function unknown]; Region: COG3698 484021004851 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 484021004852 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 484021004853 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 484021004854 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 484021004855 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 484021004856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021004857 Protein of unknown function (DUF419); Region: DUF419; cl15265 484021004858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004859 dimer interface [polypeptide binding]; other site 484021004860 conserved gate region; other site 484021004861 putative PBP binding loops; other site 484021004862 ABC-ATPase subunit interface; other site 484021004863 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 484021004864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 484021004865 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 484021004866 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021004867 Walker A/P-loop; other site 484021004868 ATP binding site [chemical binding]; other site 484021004869 Q-loop/lid; other site 484021004870 ABC transporter signature motif; other site 484021004871 Walker B; other site 484021004872 D-loop; other site 484021004873 H-loop/switch region; other site 484021004874 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 484021004875 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 484021004876 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021004877 Walker A/P-loop; other site 484021004878 ATP binding site [chemical binding]; other site 484021004879 Q-loop/lid; other site 484021004880 ABC transporter signature motif; other site 484021004881 Walker B; other site 484021004882 D-loop; other site 484021004883 H-loop/switch region; other site 484021004884 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021004885 allantoate amidohydrolase; Reviewed; Region: PRK12893 484021004886 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 484021004887 active site 484021004888 metal binding site [ion binding]; metal-binding site 484021004889 dimer interface [polypeptide binding]; other site 484021004890 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021004891 EamA-like transporter family; Region: EamA; cl17759 484021004892 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021004893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021004894 DNA-binding site [nucleotide binding]; DNA binding site 484021004895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021004896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021004897 homodimer interface [polypeptide binding]; other site 484021004898 catalytic residue [active] 484021004899 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021004900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021004901 DNA-binding site [nucleotide binding]; DNA binding site 484021004902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021004903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021004904 homodimer interface [polypeptide binding]; other site 484021004905 catalytic residue [active] 484021004906 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021004907 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021004908 substrate binding pocket [chemical binding]; other site 484021004909 membrane-bound complex binding site; other site 484021004910 hinge residues; other site 484021004911 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021004912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004913 dimer interface [polypeptide binding]; other site 484021004914 conserved gate region; other site 484021004915 putative PBP binding loops; other site 484021004916 ABC-ATPase subunit interface; other site 484021004917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004918 dimer interface [polypeptide binding]; other site 484021004919 conserved gate region; other site 484021004920 putative PBP binding loops; other site 484021004921 ABC-ATPase subunit interface; other site 484021004922 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021004923 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021004924 Walker A/P-loop; other site 484021004925 ATP binding site [chemical binding]; other site 484021004926 Q-loop/lid; other site 484021004927 ABC transporter signature motif; other site 484021004928 Walker B; other site 484021004929 D-loop; other site 484021004930 H-loop/switch region; other site 484021004931 malonic semialdehyde reductase; Provisional; Region: PRK10538 484021004932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021004933 NAD(P) binding site [chemical binding]; other site 484021004934 active site 484021004935 hypothetical protein; Provisional; Region: PRK06062 484021004936 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021004937 inhibitor-cofactor binding pocket; inhibition site 484021004938 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021004939 catalytic residue [active] 484021004940 putative transposase OrfB; Reviewed; Region: PHA02517 484021004941 HTH-like domain; Region: HTH_21; pfam13276 484021004942 Integrase core domain; Region: rve; pfam00665 484021004943 Integrase core domain; Region: rve_2; pfam13333 484021004944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021004945 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021004946 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021004947 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484021004948 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021004949 Walker A/P-loop; other site 484021004950 ATP binding site [chemical binding]; other site 484021004951 Q-loop/lid; other site 484021004952 ABC transporter signature motif; other site 484021004953 Walker B; other site 484021004954 D-loop; other site 484021004955 H-loop/switch region; other site 484021004956 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484021004957 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021004958 Walker A/P-loop; other site 484021004959 ATP binding site [chemical binding]; other site 484021004960 Q-loop/lid; other site 484021004961 ABC transporter signature motif; other site 484021004962 Walker B; other site 484021004963 D-loop; other site 484021004964 H-loop/switch region; other site 484021004965 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484021004966 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021004967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004968 dimer interface [polypeptide binding]; other site 484021004969 conserved gate region; other site 484021004970 ABC-ATPase subunit interface; other site 484021004971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021004972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021004973 dimer interface [polypeptide binding]; other site 484021004974 conserved gate region; other site 484021004975 putative PBP binding loops; other site 484021004976 ABC-ATPase subunit interface; other site 484021004977 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021004978 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 484021004979 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484021004980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021004981 choline dehydrogenase; Validated; Region: PRK02106 484021004982 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 484021004983 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 484021004984 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 484021004985 tetrameric interface [polypeptide binding]; other site 484021004986 NAD binding site [chemical binding]; other site 484021004987 catalytic residues [active] 484021004988 transcriptional regulator BetI; Validated; Region: PRK00767 484021004989 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021004990 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 484021004991 choline transport protein BetT; Provisional; Region: PRK09928 484021004992 C-lysozyme inhibitor; Provisional; Region: PRK09993 484021004993 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484021004994 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021004995 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484021004996 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021004997 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021004998 dimerization interface [polypeptide binding]; other site 484021004999 substrate binding pocket [chemical binding]; other site 484021005000 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484021005001 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 484021005002 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 484021005003 dimer interface [polypeptide binding]; other site 484021005004 N-terminal domain interface [polypeptide binding]; other site 484021005005 putative substrate binding pocket (H-site) [chemical binding]; other site 484021005006 short chain dehydrogenase; Provisional; Region: PRK06114 484021005007 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021005008 NAD(P) binding site [chemical binding]; other site 484021005009 active site 484021005010 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484021005011 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 484021005012 NAD binding site [chemical binding]; other site 484021005013 homotetramer interface [polypeptide binding]; other site 484021005014 homodimer interface [polypeptide binding]; other site 484021005015 active site 484021005016 substrate binding site [chemical binding]; other site 484021005017 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021005018 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021005019 TM-ABC transporter signature motif; other site 484021005020 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021005021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021005022 Walker A/P-loop; other site 484021005023 ATP binding site [chemical binding]; other site 484021005024 Q-loop/lid; other site 484021005025 ABC transporter signature motif; other site 484021005026 Walker B; other site 484021005027 D-loop; other site 484021005028 H-loop/switch region; other site 484021005029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021005030 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 484021005031 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484021005032 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 484021005033 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 484021005034 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 484021005035 N- and C-terminal domain interface [polypeptide binding]; other site 484021005036 active site 484021005037 MgATP binding site [chemical binding]; other site 484021005038 catalytic site [active] 484021005039 metal binding site [ion binding]; metal-binding site 484021005040 putative homotetramer interface [polypeptide binding]; other site 484021005041 putative homodimer interface [polypeptide binding]; other site 484021005042 glycerol binding site [chemical binding]; other site 484021005043 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 484021005044 MarR family; Region: MarR_2; cl17246 484021005045 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 484021005046 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484021005047 TPP-binding site [chemical binding]; other site 484021005048 dimer interface [polypeptide binding]; other site 484021005049 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 484021005050 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484021005051 PYR/PP interface [polypeptide binding]; other site 484021005052 dimer interface [polypeptide binding]; other site 484021005053 TPP binding site [chemical binding]; other site 484021005054 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021005055 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 484021005056 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 484021005057 outer membrane receptor FepA; Provisional; Region: PRK13524 484021005058 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021005059 N-terminal plug; other site 484021005060 ligand-binding site [chemical binding]; other site 484021005061 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 484021005062 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 484021005063 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 484021005064 MbtH-like protein; Region: MbtH; cl01279 484021005065 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 484021005066 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 484021005067 acyl-activating enzyme (AAE) consensus motif; other site 484021005068 AMP binding site [chemical binding]; other site 484021005069 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484021005070 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 484021005071 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021005072 Walker A/P-loop; other site 484021005073 ATP binding site [chemical binding]; other site 484021005074 Q-loop/lid; other site 484021005075 ABC transporter signature motif; other site 484021005076 Walker B; other site 484021005077 D-loop; other site 484021005078 H-loop/switch region; other site 484021005079 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 484021005080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021005081 ABC-ATPase subunit interface; other site 484021005082 dimer interface [polypeptide binding]; other site 484021005083 putative PBP binding regions; other site 484021005084 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021005085 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021005086 ABC-ATPase subunit interface; other site 484021005087 dimer interface [polypeptide binding]; other site 484021005088 putative PBP binding regions; other site 484021005089 enterobactin exporter EntS; Provisional; Region: PRK10489 484021005090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005091 putative substrate translocation pore; other site 484021005092 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 484021005093 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 484021005094 siderophore binding site; other site 484021005095 isochorismate synthase EntC; Provisional; Region: PRK15016 484021005096 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 484021005097 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 484021005098 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 484021005099 acyl-activating enzyme (AAE) consensus motif; other site 484021005100 active site 484021005101 AMP binding site [chemical binding]; other site 484021005102 substrate binding site [chemical binding]; other site 484021005103 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 484021005104 hydrophobic substrate binding pocket; other site 484021005105 Isochorismatase family; Region: Isochorismatase; pfam00857 484021005106 active site 484021005107 conserved cis-peptide bond; other site 484021005108 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 484021005109 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 484021005110 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 484021005111 putative NAD(P) binding site [chemical binding]; other site 484021005112 active site 484021005113 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484021005114 CoenzymeA binding site [chemical binding]; other site 484021005115 subunit interaction site [polypeptide binding]; other site 484021005116 PHB binding site; other site 484021005117 carbon starvation protein A; Provisional; Region: PRK15015 484021005118 Carbon starvation protein CstA; Region: CstA; pfam02554 484021005119 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 484021005120 Uncharacterized small protein [Function unknown]; Region: COG2879 484021005121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021005122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021005123 salt bridge; other site 484021005124 non-specific DNA binding site [nucleotide binding]; other site 484021005125 sequence-specific DNA binding site [nucleotide binding]; other site 484021005126 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 484021005127 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484021005128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021005129 NAD(P) binding site [chemical binding]; other site 484021005130 active site 484021005131 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 484021005132 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 484021005133 putative active site [active] 484021005134 metal binding site [ion binding]; metal-binding site 484021005135 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021005136 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021005137 Walker A/P-loop; other site 484021005138 ATP binding site [chemical binding]; other site 484021005139 Q-loop/lid; other site 484021005140 ABC transporter signature motif; other site 484021005141 Walker B; other site 484021005142 D-loop; other site 484021005143 H-loop/switch region; other site 484021005144 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021005145 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021005146 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021005147 TM-ABC transporter signature motif; other site 484021005148 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 484021005149 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 484021005150 putative ligand binding site [chemical binding]; other site 484021005151 Uncharacterized conserved protein [Function unknown]; Region: COG5276 484021005152 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 484021005153 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 484021005154 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 484021005155 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 484021005156 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 484021005157 catalytic core [active] 484021005158 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 484021005159 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 484021005160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005161 putative substrate translocation pore; other site 484021005162 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 484021005163 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 484021005164 active site 484021005165 dimerization interface [polypeptide binding]; other site 484021005166 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021005167 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021005168 DNA binding site [nucleotide binding] 484021005169 domain linker motif; other site 484021005170 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 484021005171 putative dimerization interface [polypeptide binding]; other site 484021005172 putative ligand binding site [chemical binding]; other site 484021005173 cytosine deaminase; Provisional; Region: PRK09230 484021005174 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 484021005175 active site 484021005176 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 484021005177 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 484021005178 cytosine permease; Provisional; Region: codB; PRK11017 484021005179 Na binding site [ion binding]; other site 484021005180 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 484021005181 intersubunit interface [polypeptide binding]; other site 484021005182 active site 484021005183 Zn2+ binding site [ion binding]; other site 484021005184 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 484021005185 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 484021005186 putative N- and C-terminal domain interface [polypeptide binding]; other site 484021005187 putative active site [active] 484021005188 MgATP binding site [chemical binding]; other site 484021005189 catalytic site [active] 484021005190 metal binding site [ion binding]; metal-binding site 484021005191 putative xylulose binding site [chemical binding]; other site 484021005192 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 484021005193 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 484021005194 putative ligand binding site [chemical binding]; other site 484021005195 putative NAD binding site [chemical binding]; other site 484021005196 catalytic site [active] 484021005197 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021005198 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484021005199 substrate binding site [chemical binding]; other site 484021005200 ATP binding site [chemical binding]; other site 484021005201 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021005202 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021005203 TM-ABC transporter signature motif; other site 484021005204 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021005205 TM-ABC transporter signature motif; other site 484021005206 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 484021005207 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021005208 Walker A/P-loop; other site 484021005209 ATP binding site [chemical binding]; other site 484021005210 Q-loop/lid; other site 484021005211 ABC transporter signature motif; other site 484021005212 Walker B; other site 484021005213 D-loop; other site 484021005214 H-loop/switch region; other site 484021005215 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021005216 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 484021005217 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 484021005218 putative ligand binding site [chemical binding]; other site 484021005219 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 484021005220 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 484021005221 molybdopterin cofactor binding site [chemical binding]; other site 484021005222 substrate binding site [chemical binding]; other site 484021005223 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 484021005224 molybdopterin cofactor binding site; other site 484021005225 ARD/ARD' family; Region: ARD; pfam03079 484021005226 Cupin domain; Region: Cupin_2; cl17218 484021005227 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 484021005228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005229 motif II; other site 484021005230 methionine aminotransferase; Validated; Region: PRK09082 484021005231 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021005232 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021005233 homodimer interface [polypeptide binding]; other site 484021005234 catalytic residue [active] 484021005235 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 484021005236 ParB-like nuclease domain; Region: ParBc; pfam02195 484021005237 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 484021005238 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 484021005239 Active Sites [active] 484021005240 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 484021005241 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 484021005242 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021005243 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021005244 dimerization interface [polypeptide binding]; other site 484021005245 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 484021005246 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 484021005247 dimerization domain [polypeptide binding]; other site 484021005248 dimer interface [polypeptide binding]; other site 484021005249 catalytic residues [active] 484021005250 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 484021005251 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 484021005252 dimer interface [polypeptide binding]; other site 484021005253 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484021005254 catalytic triad [active] 484021005255 peroxidatic and resolving cysteines [active] 484021005256 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 484021005257 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 484021005258 catalytic residue [active] 484021005259 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 484021005260 catalytic residues [active] 484021005261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021005262 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021005263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021005264 Ligand Binding Site [chemical binding]; other site 484021005265 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 484021005266 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 484021005267 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 484021005268 B1 nucleotide binding pocket [chemical binding]; other site 484021005269 B2 nucleotide binding pocket [chemical binding]; other site 484021005270 CAS motifs; other site 484021005271 active site 484021005272 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 484021005273 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 484021005274 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 484021005275 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484021005276 DNA-binding site [nucleotide binding]; DNA binding site 484021005277 RNA-binding motif; other site 484021005278 chromosome condensation membrane protein; Provisional; Region: PRK14196 484021005279 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484021005280 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 484021005281 putative active site [active] 484021005282 catalytic triad [active] 484021005283 putative dimer interface [polypeptide binding]; other site 484021005284 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 484021005285 lipoyl synthase; Provisional; Region: PRK05481 484021005286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021005287 FeS/SAM binding site; other site 484021005288 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 484021005289 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021005290 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 484021005291 substrate binding pocket [chemical binding]; other site 484021005292 dimerization interface [polypeptide binding]; other site 484021005293 lipoate-protein ligase B; Provisional; Region: PRK14342 484021005294 hypothetical protein; Provisional; Region: PRK04998 484021005295 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 484021005296 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 484021005297 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 484021005298 rare lipoprotein A; Provisional; Region: PRK10672 484021005299 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 484021005300 Sporulation related domain; Region: SPOR; pfam05036 484021005301 cell wall shape-determining protein; Provisional; Region: PRK10794 484021005302 penicillin-binding protein 2; Provisional; Region: PRK10795 484021005303 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484021005304 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484021005305 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 484021005306 ribosome-associated protein; Provisional; Region: PRK11538 484021005307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484021005308 catalytic core [active] 484021005309 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 484021005310 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 484021005311 active site 484021005312 (T/H)XGH motif; other site 484021005313 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 484021005314 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 484021005315 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 484021005316 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 484021005317 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 484021005318 HIGH motif; other site 484021005319 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 484021005320 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484021005321 active site 484021005322 KMSKS motif; other site 484021005323 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 484021005324 tRNA binding surface [nucleotide binding]; other site 484021005325 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484021005326 hypothetical protein; Provisional; Region: PRK11032 484021005327 haemagglutination activity domain; Region: Haemagg_act; pfam05860 484021005328 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 484021005329 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 484021005330 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 484021005331 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021005332 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021005333 Walker A/P-loop; other site 484021005334 ATP binding site [chemical binding]; other site 484021005335 Q-loop/lid; other site 484021005336 ABC transporter signature motif; other site 484021005337 Walker B; other site 484021005338 D-loop; other site 484021005339 H-loop/switch region; other site 484021005340 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021005341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021005342 dimer interface [polypeptide binding]; other site 484021005343 conserved gate region; other site 484021005344 putative PBP binding loops; other site 484021005345 ABC-ATPase subunit interface; other site 484021005346 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021005347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021005348 dimer interface [polypeptide binding]; other site 484021005349 conserved gate region; other site 484021005350 putative PBP binding loops; other site 484021005351 ABC-ATPase subunit interface; other site 484021005352 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 484021005353 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021005354 substrate binding pocket [chemical binding]; other site 484021005355 membrane-bound complex binding site; other site 484021005356 hinge residues; other site 484021005357 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 484021005358 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 484021005359 putative active site [active] 484021005360 catalytic triad [active] 484021005361 putative dimer interface [polypeptide binding]; other site 484021005362 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 484021005363 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484021005364 Transporter associated domain; Region: CorC_HlyC; smart01091 484021005365 metal-binding heat shock protein; Provisional; Region: PRK00016 484021005366 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 484021005367 PhoH-like protein; Region: PhoH; pfam02562 484021005368 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 484021005369 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484021005370 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021005371 FeS/SAM binding site; other site 484021005372 TRAM domain; Region: TRAM; pfam01938 484021005373 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 484021005374 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484021005375 asparagine synthetase B; Provisional; Region: asnB; PRK09431 484021005376 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 484021005377 active site 484021005378 dimer interface [polypeptide binding]; other site 484021005379 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 484021005380 Ligand Binding Site [chemical binding]; other site 484021005381 Molecular Tunnel; other site 484021005382 UMP phosphatase; Provisional; Region: PRK10444 484021005383 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005384 active site 484021005385 motif I; other site 484021005386 motif II; other site 484021005387 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005388 MarR family; Region: MarR; pfam01047 484021005389 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484021005390 ROK family; Region: ROK; pfam00480 484021005391 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 484021005392 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 484021005393 active site 484021005394 dimer interface [polypeptide binding]; other site 484021005395 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 484021005396 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 484021005397 active site 484021005398 trimer interface [polypeptide binding]; other site 484021005399 allosteric site; other site 484021005400 active site lid [active] 484021005401 hexamer (dimer of trimers) interface [polypeptide binding]; other site 484021005402 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 484021005403 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021005404 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021005405 active site turn [active] 484021005406 phosphorylation site [posttranslational modification] 484021005407 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 484021005408 HPr interaction site; other site 484021005409 glycerol kinase (GK) interaction site [polypeptide binding]; other site 484021005410 active site 484021005411 phosphorylation site [posttranslational modification] 484021005412 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 484021005413 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484021005414 active site 484021005415 HIGH motif; other site 484021005416 nucleotide binding site [chemical binding]; other site 484021005417 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 484021005418 KMSKS motif; other site 484021005419 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 484021005420 potential frameshift: common BLAST hit: gi|206578499|ref|YP_002239682.1| outer membrane porin, OprD family 484021005421 outer membrane porin, OprD family; Region: OprD; pfam03573 484021005422 outer membrane porin, OprD family; Region: OprD; pfam03573 484021005423 YbfN-like lipoprotein; Region: YbfN; pfam13982 484021005424 citrate-proton symporter; Provisional; Region: PRK15075 484021005425 ferric uptake regulator; Provisional; Region: fur; PRK09462 484021005426 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484021005427 metal binding site 2 [ion binding]; metal-binding site 484021005428 putative DNA binding helix; other site 484021005429 metal binding site 1 [ion binding]; metal-binding site 484021005430 dimer interface [polypeptide binding]; other site 484021005431 structural Zn2+ binding site [ion binding]; other site 484021005432 flavodoxin FldA; Validated; Region: PRK09267 484021005433 LexA regulated protein; Provisional; Region: PRK11675 484021005434 acyl-CoA esterase; Provisional; Region: PRK10673 484021005435 PGAP1-like protein; Region: PGAP1; pfam07819 484021005436 replication initiation regulator SeqA; Provisional; Region: PRK11187 484021005437 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 484021005438 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 484021005439 active site 484021005440 substrate binding site [chemical binding]; other site 484021005441 metal binding site [ion binding]; metal-binding site 484021005442 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 484021005443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021005444 active site 484021005445 phosphorylation site [posttranslational modification] 484021005446 intermolecular recognition site; other site 484021005447 dimerization interface [polypeptide binding]; other site 484021005448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021005449 DNA binding site [nucleotide binding] 484021005450 sensor protein KdpD; Provisional; Region: PRK10490 484021005451 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 484021005452 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 484021005453 Ligand Binding Site [chemical binding]; other site 484021005454 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 484021005455 GAF domain; Region: GAF_3; pfam13492 484021005456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021005457 dimer interface [polypeptide binding]; other site 484021005458 phosphorylation site [posttranslational modification] 484021005459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021005460 ATP binding site [chemical binding]; other site 484021005461 Mg2+ binding site [ion binding]; other site 484021005462 G-X-G motif; other site 484021005463 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 484021005464 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 484021005465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021005466 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 484021005467 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 484021005468 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 484021005469 DNA photolyase; Region: DNA_photolyase; pfam00875 484021005470 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484021005471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005472 putative substrate translocation pore; other site 484021005473 POT family; Region: PTR2; pfam00854 484021005474 Uncharacterized conserved protein [Function unknown]; Region: COG0327 484021005475 metal-binding protein; Provisional; Region: PRK10799 484021005476 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 484021005477 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 484021005478 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 484021005479 LamB/YcsF family protein; Provisional; Region: PRK05406 484021005480 Protein of unknown function (DUF969); Region: DUF969; pfam06149 484021005481 Predicted membrane protein [Function unknown]; Region: COG3817 484021005482 Protein of unknown function (DUF979); Region: DUF979; pfam06166 484021005483 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 484021005484 putative substrate binding pocket [chemical binding]; other site 484021005485 AC domain interface; other site 484021005486 catalytic triad [active] 484021005487 AB domain interface; other site 484021005488 interchain disulfide; other site 484021005489 endonuclease VIII; Provisional; Region: PRK10445 484021005490 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 484021005491 DNA binding site [nucleotide binding] 484021005492 catalytic residue [active] 484021005493 putative catalytic residues [active] 484021005494 H2TH interface [polypeptide binding]; other site 484021005495 intercalation triad [nucleotide binding]; other site 484021005496 substrate specificity determining residue; other site 484021005497 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 484021005498 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484021005499 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 484021005500 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 484021005501 dimer interface [polypeptide binding]; other site 484021005502 active site 484021005503 citrylCoA binding site [chemical binding]; other site 484021005504 NADH binding [chemical binding]; other site 484021005505 cationic pore residues; other site 484021005506 oxalacetate/citrate binding site [chemical binding]; other site 484021005507 coenzyme A binding site [chemical binding]; other site 484021005508 catalytic triad [active] 484021005509 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 484021005510 Iron-sulfur protein interface; other site 484021005511 proximal quinone binding site [chemical binding]; other site 484021005512 SdhD (CybS) interface [polypeptide binding]; other site 484021005513 proximal heme binding site [chemical binding]; other site 484021005514 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 484021005515 SdhC subunit interface [polypeptide binding]; other site 484021005516 proximal heme binding site [chemical binding]; other site 484021005517 cardiolipin binding site; other site 484021005518 Iron-sulfur protein interface; other site 484021005519 proximal quinone binding site [chemical binding]; other site 484021005520 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 484021005521 L-aspartate oxidase; Provisional; Region: PRK06175 484021005522 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484021005523 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 484021005524 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 484021005525 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 484021005526 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 484021005527 TPP-binding site [chemical binding]; other site 484021005528 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 484021005529 dimer interface [polypeptide binding]; other site 484021005530 PYR/PP interface [polypeptide binding]; other site 484021005531 TPP binding site [chemical binding]; other site 484021005532 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 484021005533 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 484021005534 E3 interaction surface; other site 484021005535 lipoyl attachment site [posttranslational modification]; other site 484021005536 e3 binding domain; Region: E3_binding; pfam02817 484021005537 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 484021005538 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 484021005539 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 484021005540 CoA-ligase; Region: Ligase_CoA; pfam00549 484021005541 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 484021005542 CoA binding domain; Region: CoA_binding; smart00881 484021005543 CoA-ligase; Region: Ligase_CoA; pfam00549 484021005544 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 484021005545 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 484021005546 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 484021005547 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 484021005548 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 484021005549 hypothetical protein; Provisional; Region: PRK10588 484021005550 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 484021005551 active site 484021005552 colicin uptake protein TolQ; Provisional; Region: PRK10801 484021005553 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 484021005554 colicin uptake protein TolR; Provisional; Region: PRK11024 484021005555 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 484021005556 TolA C-terminal; Region: TolA; pfam06519 484021005557 translocation protein TolB; Provisional; Region: tolB; PRK03629 484021005558 TolB amino-terminal domain; Region: TolB_N; pfam04052 484021005559 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 484021005560 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 484021005561 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 484021005562 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 484021005563 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484021005564 ligand binding site [chemical binding]; other site 484021005565 tol-pal system protein YbgF; Provisional; Region: PRK10803 484021005566 Tetratricopeptide repeat; Region: TPR_6; pfam13174 484021005567 Tetratricopeptide repeat; Region: TPR_6; pfam13174 484021005568 quinolinate synthetase; Provisional; Region: PRK09375 484021005569 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 484021005570 zinc transporter ZitB; Provisional; Region: PRK03557 484021005571 YbgS-like protein; Region: YbgS; pfam13985 484021005572 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 484021005573 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484021005574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484021005575 catalytic core [active] 484021005576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484021005577 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 484021005578 active site 484021005579 catalytic residues [active] 484021005580 galactokinase; Provisional; Region: PRK05101 484021005581 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 484021005582 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484021005583 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 484021005584 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 484021005585 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 484021005586 dimer interface [polypeptide binding]; other site 484021005587 active site 484021005588 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 484021005589 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 484021005590 NAD binding site [chemical binding]; other site 484021005591 homodimer interface [polypeptide binding]; other site 484021005592 active site 484021005593 substrate binding site [chemical binding]; other site 484021005594 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 484021005595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021005596 Walker A/P-loop; other site 484021005597 ATP binding site [chemical binding]; other site 484021005598 Q-loop/lid; other site 484021005599 ABC transporter signature motif; other site 484021005600 Walker B; other site 484021005601 D-loop; other site 484021005602 H-loop/switch region; other site 484021005603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021005604 Walker A/P-loop; other site 484021005605 ATP binding site [chemical binding]; other site 484021005606 Q-loop/lid; other site 484021005607 ABC transporter signature motif; other site 484021005608 Walker B; other site 484021005609 D-loop; other site 484021005610 H-loop/switch region; other site 484021005611 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 484021005612 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 484021005613 molybdenum-pterin binding domain; Region: Mop; TIGR00638 484021005614 TOBE domain; Region: TOBE; pfam03459 484021005615 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 484021005616 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 484021005617 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021005618 substrate binding pocket [chemical binding]; other site 484021005619 membrane-bound complex binding site; other site 484021005620 hinge residues; other site 484021005621 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 484021005622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021005623 dimer interface [polypeptide binding]; other site 484021005624 conserved gate region; other site 484021005625 putative PBP binding loops; other site 484021005626 ABC-ATPase subunit interface; other site 484021005627 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 484021005628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021005629 Walker A/P-loop; other site 484021005630 ATP binding site [chemical binding]; other site 484021005631 Q-loop/lid; other site 484021005632 ABC transporter signature motif; other site 484021005633 Walker B; other site 484021005634 D-loop; other site 484021005635 H-loop/switch region; other site 484021005636 TOBE domain; Region: TOBE; cl01440 484021005637 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 484021005638 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005639 active site 484021005640 motif I; other site 484021005641 motif II; other site 484021005642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005643 6-phosphogluconolactonase; Provisional; Region: PRK11028 484021005644 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 484021005645 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 484021005646 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 484021005647 Sensors of blue-light using FAD; Region: BLUF; smart01034 484021005648 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021005649 transcriptional regulator MirA; Provisional; Region: PRK15043 484021005650 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 484021005651 DNA binding residues [nucleotide binding] 484021005652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021005653 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021005654 DNA binding residues [nucleotide binding] 484021005655 dimerization interface [polypeptide binding]; other site 484021005656 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 484021005657 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 484021005658 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 484021005659 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484021005660 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021005661 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021005662 Ligand Binding Site [chemical binding]; other site 484021005663 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 484021005664 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 484021005665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021005666 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 484021005667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005668 motif I; other site 484021005669 motif II; other site 484021005670 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484021005671 acyl-CoA thioesterase; Provisional; Region: PRK10531 484021005672 putative pectinesterase; Region: PLN02432; cl01911 484021005673 imidazolonepropionase; Validated; Region: PRK09356 484021005674 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 484021005675 active site 484021005676 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 484021005677 putative active site [active] 484021005678 putative metal binding site [ion binding]; other site 484021005679 histidine utilization repressor; Provisional; Region: PRK14999 484021005680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021005681 DNA-binding site [nucleotide binding]; DNA binding site 484021005682 UTRA domain; Region: UTRA; pfam07702 484021005683 urocanate hydratase; Provisional; Region: PRK05414 484021005684 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 484021005685 active sites [active] 484021005686 tetramer interface [polypeptide binding]; other site 484021005687 putative proline-specific permease; Provisional; Region: proY; PRK10580 484021005688 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 484021005689 substrate binding site [chemical binding]; other site 484021005690 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 484021005691 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021005692 inhibitor-cofactor binding pocket; inhibition site 484021005693 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021005694 catalytic residue [active] 484021005695 biotin synthase; Provisional; Region: PRK15108 484021005696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021005697 FeS/SAM binding site; other site 484021005698 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 484021005699 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 484021005700 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 484021005701 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021005702 catalytic residue [active] 484021005703 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 484021005704 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021005705 S-adenosylmethionine binding site [chemical binding]; other site 484021005706 AAA domain; Region: AAA_26; pfam13500 484021005707 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 484021005708 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 484021005709 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 484021005710 Walker A/P-loop; other site 484021005711 ATP binding site [chemical binding]; other site 484021005712 Q-loop/lid; other site 484021005713 ABC transporter signature motif; other site 484021005714 Walker B; other site 484021005715 D-loop; other site 484021005716 H-loop/switch region; other site 484021005717 excinuclease ABC subunit B; Provisional; Region: PRK05298 484021005718 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021005719 ATP binding site [chemical binding]; other site 484021005720 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021005721 nucleotide binding region [chemical binding]; other site 484021005722 ATP-binding site [chemical binding]; other site 484021005723 Ultra-violet resistance protein B; Region: UvrB; pfam12344 484021005724 UvrB/uvrC motif; Region: UVR; pfam02151 484021005725 sensor protein BasS/PmrB; Provisional; Region: PRK10755 484021005726 HAMP domain; Region: HAMP; pfam00672 484021005727 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021005728 ATP binding site [chemical binding]; other site 484021005729 Mg2+ binding site [ion binding]; other site 484021005730 G-X-G motif; other site 484021005731 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 484021005732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021005733 active site 484021005734 phosphorylation site [posttranslational modification] 484021005735 intermolecular recognition site; other site 484021005736 dimerization interface [polypeptide binding]; other site 484021005737 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021005738 DNA binding site [nucleotide binding] 484021005739 putative metal dependent hydrolase; Provisional; Region: PRK11598 484021005740 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 484021005741 Sulfatase; Region: Sulfatase; pfam00884 484021005742 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 484021005743 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 484021005744 phosphate binding site [ion binding]; other site 484021005745 putative substrate binding pocket [chemical binding]; other site 484021005746 dimer interface [polypeptide binding]; other site 484021005747 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 484021005748 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021005749 FeS/SAM binding site; other site 484021005750 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 484021005751 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 484021005752 MPT binding site; other site 484021005753 trimer interface [polypeptide binding]; other site 484021005754 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 484021005755 trimer interface [polypeptide binding]; other site 484021005756 dimer interface [polypeptide binding]; other site 484021005757 putative active site [active] 484021005758 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 484021005759 MoaE interaction surface [polypeptide binding]; other site 484021005760 MoeB interaction surface [polypeptide binding]; other site 484021005761 thiocarboxylated glycine; other site 484021005762 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 484021005763 MoaE homodimer interface [polypeptide binding]; other site 484021005764 MoaD interaction [polypeptide binding]; other site 484021005765 active site residues [active] 484021005766 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 484021005767 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 484021005768 Predicted integral membrane protein [Function unknown]; Region: COG0392 484021005769 cardiolipin synthase 2; Provisional; Region: PRK11263 484021005770 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 484021005771 putative active site [active] 484021005772 catalytic site [active] 484021005773 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 484021005774 putative active site [active] 484021005775 catalytic site [active] 484021005776 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 484021005777 putative catalytic site [active] 484021005778 putative metal binding site [ion binding]; other site 484021005779 putative phosphate binding site [ion binding]; other site 484021005780 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 484021005781 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484021005782 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484021005783 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484021005784 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 484021005785 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484021005786 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484021005787 Walker A/P-loop; other site 484021005788 ATP binding site [chemical binding]; other site 484021005789 Q-loop/lid; other site 484021005790 ABC transporter signature motif; other site 484021005791 Walker B; other site 484021005792 D-loop; other site 484021005793 H-loop/switch region; other site 484021005794 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 484021005795 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484021005796 Walker A/P-loop; other site 484021005797 ATP binding site [chemical binding]; other site 484021005798 Q-loop/lid; other site 484021005799 ABC transporter signature motif; other site 484021005800 Walker B; other site 484021005801 D-loop; other site 484021005802 H-loop/switch region; other site 484021005803 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 484021005804 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021005805 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021005806 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 484021005807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021005808 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 484021005809 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484021005810 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021005811 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021005812 dimerization interface [polypeptide binding]; other site 484021005813 substrate binding pocket [chemical binding]; other site 484021005814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005815 D-galactonate transporter; Region: 2A0114; TIGR00893 484021005816 putative substrate translocation pore; other site 484021005817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005818 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484021005819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021005820 NAD(P) binding site [chemical binding]; other site 484021005821 active site 484021005822 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484021005823 TPP-binding site [chemical binding]; other site 484021005824 dimer interface [polypeptide binding]; other site 484021005825 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 484021005826 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484021005827 PYR/PP interface [polypeptide binding]; other site 484021005828 dimer interface [polypeptide binding]; other site 484021005829 TPP binding site [chemical binding]; other site 484021005830 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021005831 helicase 45; Provisional; Region: PTZ00424 484021005832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484021005833 ATP binding site [chemical binding]; other site 484021005834 Mg++ binding site [ion binding]; other site 484021005835 motif III; other site 484021005836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021005837 nucleotide binding region [chemical binding]; other site 484021005838 ATP-binding site [chemical binding]; other site 484021005839 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 484021005840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 484021005841 DEAD_2; Region: DEAD_2; pfam06733 484021005842 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 484021005843 glycosyl transferase family protein; Provisional; Region: PRK08136 484021005844 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 484021005845 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 484021005846 hypothetical protein; Provisional; Region: PRK11019 484021005847 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 484021005848 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 484021005849 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 484021005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021005851 S-adenosylmethionine binding site [chemical binding]; other site 484021005852 putative mechanosensitive channel protein; Provisional; Region: PRK11465 484021005853 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021005854 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 484021005855 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021005856 Walker A/P-loop; other site 484021005857 ATP binding site [chemical binding]; other site 484021005858 Q-loop/lid; other site 484021005859 ABC transporter signature motif; other site 484021005860 Walker B; other site 484021005861 D-loop; other site 484021005862 H-loop/switch region; other site 484021005863 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021005864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021005865 dimer interface [polypeptide binding]; other site 484021005866 conserved gate region; other site 484021005867 putative PBP binding loops; other site 484021005868 ABC-ATPase subunit interface; other site 484021005869 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 484021005870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021005871 substrate binding pocket [chemical binding]; other site 484021005872 membrane-bound complex binding site; other site 484021005873 hinge residues; other site 484021005874 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 484021005875 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 484021005876 dimerization interface [polypeptide binding]; other site 484021005877 DPS ferroxidase diiron center [ion binding]; other site 484021005878 ion pore; other site 484021005879 threonine and homoserine efflux system; Provisional; Region: PRK10532 484021005880 EamA-like transporter family; Region: EamA; pfam00892 484021005881 outer membrane protein X; Provisional; Region: ompX; PRK09408 484021005882 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 484021005883 Sulfatase; Region: Sulfatase; pfam00884 484021005884 manganese transport regulator MntR; Provisional; Region: PRK11050 484021005885 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 484021005886 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 484021005887 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 484021005888 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 484021005889 transmembrane helices; other site 484021005890 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 484021005891 beta-galactosidase; Region: BGL; TIGR03356 484021005892 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 484021005893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021005894 DNA-binding site [nucleotide binding]; DNA binding site 484021005895 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 484021005896 L,D-transpeptidase; Provisional; Region: PRK10260 484021005897 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484021005898 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 484021005899 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 484021005900 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 484021005901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021005902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021005903 Walker A/P-loop; other site 484021005904 ATP binding site [chemical binding]; other site 484021005905 Q-loop/lid; other site 484021005906 ABC transporter signature motif; other site 484021005907 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021005908 Walker B; other site 484021005909 D-loop; other site 484021005910 ABC transporter; Region: ABC_tran_2; pfam12848 484021005911 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021005912 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 484021005913 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 484021005914 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 484021005915 putative active site [active] 484021005916 putative catalytic site [active] 484021005917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005918 D-galactonate transporter; Region: 2A0114; TIGR00893 484021005919 putative substrate translocation pore; other site 484021005920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021005921 DNA binding site [nucleotide binding] 484021005922 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021005923 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484021005924 ligand binding site [chemical binding]; other site 484021005925 dimerization interface [polypeptide binding]; other site 484021005926 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 484021005927 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 484021005928 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005929 active site 484021005930 motif I; other site 484021005931 motif II; other site 484021005932 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021005933 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 484021005934 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 484021005935 dimer interface [polypeptide binding]; other site 484021005936 active site 484021005937 glycine loop; other site 484021005938 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 484021005939 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021005940 FeS/SAM binding site; other site 484021005941 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 484021005942 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 484021005943 ATP binding site [chemical binding]; other site 484021005944 substrate interface [chemical binding]; other site 484021005945 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 484021005946 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 484021005947 dimer interface [polypeptide binding]; other site 484021005948 putative functional site; other site 484021005949 putative MPT binding site; other site 484021005950 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 484021005951 catalytic nucleophile [active] 484021005952 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 484021005953 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021005954 Walker A/P-loop; other site 484021005955 ATP binding site [chemical binding]; other site 484021005956 Q-loop/lid; other site 484021005957 ABC transporter signature motif; other site 484021005958 Walker B; other site 484021005959 D-loop; other site 484021005960 H-loop/switch region; other site 484021005961 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021005962 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021005963 Walker A/P-loop; other site 484021005964 ATP binding site [chemical binding]; other site 484021005965 Q-loop/lid; other site 484021005966 ABC transporter signature motif; other site 484021005967 Walker B; other site 484021005968 D-loop; other site 484021005969 H-loop/switch region; other site 484021005970 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 484021005971 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 484021005972 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 484021005973 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 484021005974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021005975 dimer interface [polypeptide binding]; other site 484021005976 conserved gate region; other site 484021005977 putative PBP binding loops; other site 484021005978 ABC-ATPase subunit interface; other site 484021005979 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 484021005980 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021005981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021005982 dimer interface [polypeptide binding]; other site 484021005983 conserved gate region; other site 484021005984 putative PBP binding loops; other site 484021005985 ABC-ATPase subunit interface; other site 484021005986 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 484021005987 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484021005988 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021005989 FeS/SAM binding site; other site 484021005990 galactoside permease; Reviewed; Region: lacY; PRK09528 484021005991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021005992 putative substrate translocation pore; other site 484021005993 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 484021005994 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 484021005995 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 484021005996 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484021005997 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 484021005998 putative C-terminal domain interface [polypeptide binding]; other site 484021005999 putative GSH binding site (G-site) [chemical binding]; other site 484021006000 putative dimer interface [polypeptide binding]; other site 484021006001 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 484021006002 putative N-terminal domain interface [polypeptide binding]; other site 484021006003 putative dimer interface [polypeptide binding]; other site 484021006004 putative substrate binding pocket (H-site) [chemical binding]; other site 484021006005 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 484021006006 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 484021006007 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 484021006008 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 484021006009 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 484021006010 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021006011 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 484021006012 active site 484021006013 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 484021006014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021006015 putative substrate translocation pore; other site 484021006016 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 484021006017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021006018 active site 484021006019 motif I; other site 484021006020 motif II; other site 484021006021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021006022 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484021006023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021006024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021006025 putative substrate translocation pore; other site 484021006026 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 484021006027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021006028 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 484021006029 putative transporter; Provisional; Region: PRK04972 484021006030 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 484021006031 TrkA-C domain; Region: TrkA_C; pfam02080 484021006032 TrkA-C domain; Region: TrkA_C; pfam02080 484021006033 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 484021006034 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 484021006035 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 484021006036 GSH binding site [chemical binding]; other site 484021006037 catalytic residues [active] 484021006038 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 484021006039 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 484021006040 dimer interface [polypeptide binding]; other site 484021006041 FMN binding site [chemical binding]; other site 484021006042 NADPH bind site [chemical binding]; other site 484021006043 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 484021006044 RimK-like ATP-grasp domain; Region: RimK; pfam08443 484021006045 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 484021006046 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 484021006047 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 484021006048 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 484021006049 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021006050 Walker A/P-loop; other site 484021006051 ATP binding site [chemical binding]; other site 484021006052 Q-loop/lid; other site 484021006053 ABC transporter signature motif; other site 484021006054 Walker B; other site 484021006055 D-loop; other site 484021006056 H-loop/switch region; other site 484021006057 TOBE domain; Region: TOBE_2; pfam08402 484021006058 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 484021006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006060 dimer interface [polypeptide binding]; other site 484021006061 conserved gate region; other site 484021006062 putative PBP binding loops; other site 484021006063 ABC-ATPase subunit interface; other site 484021006064 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484021006065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006066 dimer interface [polypeptide binding]; other site 484021006067 conserved gate region; other site 484021006068 putative PBP binding loops; other site 484021006069 ABC-ATPase subunit interface; other site 484021006070 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 484021006071 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 484021006072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021006073 S-adenosylmethionine binding site [chemical binding]; other site 484021006074 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484021006075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021006076 active site 484021006077 phosphorylation site [posttranslational modification] 484021006078 intermolecular recognition site; other site 484021006079 dimerization interface [polypeptide binding]; other site 484021006080 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021006081 DNA binding site [nucleotide binding] 484021006082 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 484021006083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021006084 dimer interface [polypeptide binding]; other site 484021006085 phosphorylation site [posttranslational modification] 484021006086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021006087 ATP binding site [chemical binding]; other site 484021006088 Mg2+ binding site [ion binding]; other site 484021006089 G-X-G motif; other site 484021006090 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 484021006091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021006092 substrate binding pocket [chemical binding]; other site 484021006093 membrane-bound complex binding site; other site 484021006094 hinge residues; other site 484021006095 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021006096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006097 dimer interface [polypeptide binding]; other site 484021006098 conserved gate region; other site 484021006099 putative PBP binding loops; other site 484021006100 ABC-ATPase subunit interface; other site 484021006101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021006102 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006103 dimer interface [polypeptide binding]; other site 484021006104 conserved gate region; other site 484021006105 putative PBP binding loops; other site 484021006106 ABC-ATPase subunit interface; other site 484021006107 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 484021006108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021006109 substrate binding pocket [chemical binding]; other site 484021006110 membrane-bound complex binding site; other site 484021006111 hinge residues; other site 484021006112 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 484021006113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021006114 Walker A/P-loop; other site 484021006115 ATP binding site [chemical binding]; other site 484021006116 Q-loop/lid; other site 484021006117 ABC transporter signature motif; other site 484021006118 Walker B; other site 484021006119 D-loop; other site 484021006120 H-loop/switch region; other site 484021006121 putative lipoprotein; Provisional; Region: PRK10533 484021006122 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021006123 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021006124 metal binding site [ion binding]; metal-binding site 484021006125 active site 484021006126 I-site; other site 484021006127 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 484021006128 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 484021006129 amidase catalytic site [active] 484021006130 Zn binding residues [ion binding]; other site 484021006131 substrate binding site [chemical binding]; other site 484021006132 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484021006133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021006134 NAD(P) binding site [chemical binding]; other site 484021006135 active site 484021006136 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 484021006137 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 484021006138 putative NAD(P) binding site [chemical binding]; other site 484021006139 putative active site [active] 484021006140 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 484021006141 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 484021006142 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 484021006143 tetramer interface [polypeptide binding]; other site 484021006144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021006145 catalytic residue [active] 484021006146 pyruvate dehydrogenase; Provisional; Region: PRK09124 484021006147 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 484021006148 PYR/PP interface [polypeptide binding]; other site 484021006149 dimer interface [polypeptide binding]; other site 484021006150 tetramer interface [polypeptide binding]; other site 484021006151 TPP binding site [chemical binding]; other site 484021006152 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021006153 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 484021006154 TPP-binding site [chemical binding]; other site 484021006155 DoxX; Region: DoxX; pfam07681 484021006156 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 484021006157 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 484021006158 FAD binding pocket [chemical binding]; other site 484021006159 FAD binding motif [chemical binding]; other site 484021006160 phosphate binding motif [ion binding]; other site 484021006161 beta-alpha-beta structure motif; other site 484021006162 NAD binding pocket [chemical binding]; other site 484021006163 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021006164 catalytic loop [active] 484021006165 iron binding site [ion binding]; other site 484021006166 hybrid cluster protein; Provisional; Region: PRK05290 484021006167 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 484021006168 ACS interaction site; other site 484021006169 CODH interaction site; other site 484021006170 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 484021006171 hybrid metal cluster; other site 484021006172 Predicted membrane protein [Function unknown]; Region: COG2431 484021006173 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 484021006174 amphipathic channel; other site 484021006175 Asn-Pro-Ala signature motifs; other site 484021006176 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 484021006177 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 484021006178 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 484021006179 putative active site [active] 484021006180 putative metal-binding site [ion binding]; other site 484021006181 macrolide transporter subunit MacA; Provisional; Region: PRK11578 484021006182 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021006183 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021006184 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 484021006185 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484021006186 Walker A/P-loop; other site 484021006187 ATP binding site [chemical binding]; other site 484021006188 Q-loop/lid; other site 484021006189 ABC transporter signature motif; other site 484021006190 Walker B; other site 484021006191 D-loop; other site 484021006192 H-loop/switch region; other site 484021006193 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484021006194 FtsX-like permease family; Region: FtsX; pfam02687 484021006195 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484021006196 DNA-binding site [nucleotide binding]; DNA binding site 484021006197 RNA-binding motif; other site 484021006198 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 484021006199 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 484021006200 Clp amino terminal domain; Region: Clp_N; pfam02861 484021006201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021006202 Walker A motif; other site 484021006203 ATP binding site [chemical binding]; other site 484021006204 Walker B motif; other site 484021006205 arginine finger; other site 484021006206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021006207 Walker A motif; other site 484021006208 ATP binding site [chemical binding]; other site 484021006209 Walker B motif; other site 484021006210 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484021006211 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 484021006212 rRNA binding site [nucleotide binding]; other site 484021006213 predicted 30S ribosome binding site; other site 484021006214 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 484021006215 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 484021006216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021006217 Walker A/P-loop; other site 484021006218 ATP binding site [chemical binding]; other site 484021006219 Q-loop/lid; other site 484021006220 ABC transporter signature motif; other site 484021006221 Walker B; other site 484021006222 D-loop; other site 484021006223 H-loop/switch region; other site 484021006224 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 484021006225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021006226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021006227 Walker A/P-loop; other site 484021006228 ATP binding site [chemical binding]; other site 484021006229 Q-loop/lid; other site 484021006230 ABC transporter signature motif; other site 484021006231 Walker B; other site 484021006232 D-loop; other site 484021006233 H-loop/switch region; other site 484021006234 thioredoxin reductase; Provisional; Region: PRK10262 484021006235 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021006236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021006237 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 484021006238 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021006239 putative DNA binding site [nucleotide binding]; other site 484021006240 putative Zn2+ binding site [ion binding]; other site 484021006241 AsnC family; Region: AsnC_trans_reg; pfam01037 484021006242 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 484021006243 DNA translocase FtsK; Provisional; Region: PRK10263 484021006244 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 484021006245 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 484021006246 periplasmic chaperone LolA; Region: lolA; TIGR00547 484021006247 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 484021006248 recombination factor protein RarA; Reviewed; Region: PRK13342 484021006249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021006250 Walker A motif; other site 484021006251 ATP binding site [chemical binding]; other site 484021006252 Walker B motif; other site 484021006253 arginine finger; other site 484021006254 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 484021006255 seryl-tRNA synthetase; Provisional; Region: PRK05431 484021006256 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 484021006257 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 484021006258 dimer interface [polypeptide binding]; other site 484021006259 active site 484021006260 motif 1; other site 484021006261 motif 2; other site 484021006262 motif 3; other site 484021006263 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 484021006264 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 484021006265 putative [Fe4-S4] binding site [ion binding]; other site 484021006266 putative molybdopterin cofactor binding site [chemical binding]; other site 484021006267 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 484021006268 putative molybdopterin cofactor binding site; other site 484021006269 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 484021006270 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 484021006271 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 484021006272 putative MFS family transporter protein; Provisional; Region: PRK03633 484021006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021006274 putative substrate translocation pore; other site 484021006275 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 484021006276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021006277 FeS/SAM binding site; other site 484021006278 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 484021006279 Pyruvate formate lyase 1; Region: PFL1; cd01678 484021006280 coenzyme A binding site [chemical binding]; other site 484021006281 active site 484021006282 catalytic residues [active] 484021006283 glycine loop; other site 484021006284 formate transporter; Provisional; Region: PRK10805 484021006285 uncharacterized domain; Region: TIGR00702 484021006286 YcaO-like family; Region: YcaO; pfam02624 484021006287 Predicted membrane protein [Function unknown]; Region: COG2323 484021006288 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 484021006289 homodimer interface [polypeptide binding]; other site 484021006290 substrate-cofactor binding pocket; other site 484021006291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021006292 catalytic residue [active] 484021006293 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 484021006294 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 484021006295 hinge; other site 484021006296 active site 484021006297 cytidylate kinase; Provisional; Region: cmk; PRK00023 484021006298 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 484021006299 CMP-binding site; other site 484021006300 The sites determining sugar specificity; other site 484021006301 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 484021006302 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 484021006303 RNA binding site [nucleotide binding]; other site 484021006304 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 484021006305 RNA binding site [nucleotide binding]; other site 484021006306 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 484021006307 RNA binding site [nucleotide binding]; other site 484021006308 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 484021006309 RNA binding site [nucleotide binding]; other site 484021006310 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 484021006311 RNA binding site [nucleotide binding]; other site 484021006312 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 484021006313 IHF dimer interface [polypeptide binding]; other site 484021006314 IHF - DNA interface [nucleotide binding]; other site 484021006315 ComEC family competence protein; Provisional; Region: PRK11539 484021006316 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 484021006317 Competence protein; Region: Competence; pfam03772 484021006318 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484021006319 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 484021006320 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021006321 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 484021006322 Walker A/P-loop; other site 484021006323 ATP binding site [chemical binding]; other site 484021006324 Q-loop/lid; other site 484021006325 ABC transporter signature motif; other site 484021006326 Walker B; other site 484021006327 D-loop; other site 484021006328 H-loop/switch region; other site 484021006329 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 484021006330 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 484021006331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 484021006332 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 484021006333 Trm112p-like protein; Region: Trm112p; cl01066 484021006334 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 484021006335 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 484021006336 Ligand binding site; other site 484021006337 oligomer interface; other site 484021006338 hypothetical protein; Provisional; Region: PRK10593 484021006339 Uncharacterized conserved protein [Function unknown]; Region: COG1434 484021006340 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484021006341 putative active site [active] 484021006342 Methyltransferase domain; Region: Methyltransf_31; pfam13847 484021006343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021006344 S-adenosylmethionine binding site [chemical binding]; other site 484021006345 condesin subunit F; Provisional; Region: PRK05260 484021006346 condesin subunit E; Provisional; Region: PRK05256 484021006347 cell division protein MukB; Provisional; Region: mukB; PRK04863 484021006348 P-loop containing region of AAA domain; Region: AAA_29; cl17516 484021006349 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 484021006350 murein L,D-transpeptidase; Provisional; Region: PRK10594 484021006351 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 484021006352 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484021006353 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484021006354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 484021006355 Peptidase M15; Region: Peptidase_M15_3; cl01194 484021006356 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 484021006357 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 484021006358 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021006359 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021006360 homodimer interface [polypeptide binding]; other site 484021006361 catalytic residue [active] 484021006362 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 484021006363 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 484021006364 eyelet of channel; other site 484021006365 trimer interface [polypeptide binding]; other site 484021006366 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 484021006367 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 484021006368 putative dimer interface [polypeptide binding]; other site 484021006369 putative anticodon binding site; other site 484021006370 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 484021006371 homodimer interface [polypeptide binding]; other site 484021006372 motif 1; other site 484021006373 motif 2; other site 484021006374 active site 484021006375 motif 3; other site 484021006376 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 484021006377 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021006378 putative DNA binding site [nucleotide binding]; other site 484021006379 putative Zn2+ binding site [ion binding]; other site 484021006380 AsnC family; Region: AsnC_trans_reg; pfam01037 484021006381 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 484021006382 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 484021006383 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021006384 catalytic residue [active] 484021006385 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484021006386 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 484021006387 allantoate amidohydrolase; Reviewed; Region: PRK12893 484021006388 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 484021006389 active site 484021006390 metal binding site [ion binding]; metal-binding site 484021006391 dimer interface [polypeptide binding]; other site 484021006392 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484021006393 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 484021006394 metal binding site [ion binding]; metal-binding site 484021006395 putative dimer interface [polypeptide binding]; other site 484021006396 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 484021006397 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 484021006398 active site 484021006399 aminopeptidase N; Provisional; Region: pepN; PRK14015 484021006400 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 484021006401 active site 484021006402 Zn binding site [ion binding]; other site 484021006403 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 484021006404 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484021006405 Walker A/P-loop; other site 484021006406 ATP binding site [chemical binding]; other site 484021006407 Q-loop/lid; other site 484021006408 ABC transporter signature motif; other site 484021006409 Walker B; other site 484021006410 D-loop; other site 484021006411 H-loop/switch region; other site 484021006412 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484021006413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006414 dimer interface [polypeptide binding]; other site 484021006415 conserved gate region; other site 484021006416 putative PBP binding loops; other site 484021006417 ABC-ATPase subunit interface; other site 484021006418 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 484021006419 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 484021006420 active site 484021006421 dimer interface [polypeptide binding]; other site 484021006422 non-prolyl cis peptide bond; other site 484021006423 insertion regions; other site 484021006424 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 484021006425 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021006426 substrate binding pocket [chemical binding]; other site 484021006427 membrane-bound complex binding site; other site 484021006428 hinge residues; other site 484021006429 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 484021006430 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484021006431 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 484021006432 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 484021006433 quinone interaction residues [chemical binding]; other site 484021006434 active site 484021006435 catalytic residues [active] 484021006436 FMN binding site [chemical binding]; other site 484021006437 substrate binding site [chemical binding]; other site 484021006438 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 484021006439 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 484021006440 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 484021006441 MOSC domain; Region: MOSC; pfam03473 484021006442 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 484021006443 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021006444 catalytic loop [active] 484021006445 iron binding site [ion binding]; other site 484021006446 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 484021006447 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 484021006448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484021006449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021006450 S-adenosylmethionine binding site [chemical binding]; other site 484021006451 ABC transporter ATPase component; Reviewed; Region: PRK11147 484021006452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021006453 Walker A/P-loop; other site 484021006454 ATP binding site [chemical binding]; other site 484021006455 Q-loop/lid; other site 484021006456 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021006457 ABC transporter; Region: ABC_tran_2; pfam12848 484021006458 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021006459 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 484021006460 Paraquat-inducible protein A; Region: PqiA; pfam04403 484021006461 Paraquat-inducible protein A; Region: PqiA; pfam04403 484021006462 paraquat-inducible protein B; Provisional; Region: PRK10807 484021006463 mce related protein; Region: MCE; pfam02470 484021006464 mce related protein; Region: MCE; pfam02470 484021006465 mce related protein; Region: MCE; pfam02470 484021006466 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 484021006467 Protein of unknown function (DUF330); Region: DUF330; pfam03886 484021006468 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 484021006469 active site 1 [active] 484021006470 dimer interface [polypeptide binding]; other site 484021006471 active site 2 [active] 484021006472 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 484021006473 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 484021006474 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 484021006475 outer membrane protein A; Reviewed; Region: PRK10808 484021006476 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 484021006477 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484021006478 ligand binding site [chemical binding]; other site 484021006479 SOS cell division inhibitor; Provisional; Region: PRK10595 484021006480 TfoX N-terminal domain; Region: TfoX_N; pfam04993 484021006481 TfoX C-terminal domain; Region: TfoX_C; pfam04994 484021006482 TIGR01666 family membrane protein; Region: YCCS 484021006483 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 484021006484 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484021006485 Predicted membrane protein [Function unknown]; Region: COG3304 484021006486 Domain of unknown function (DUF307); Region: DUF307; pfam03733 484021006487 Domain of unknown function (DUF307); Region: DUF307; pfam03733 484021006488 DNA helicase IV; Provisional; Region: helD; PRK11054 484021006489 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 484021006490 Part of AAA domain; Region: AAA_19; pfam13245 484021006491 Family description; Region: UvrD_C_2; pfam13538 484021006492 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 484021006493 active site 484021006494 dimer interfaces [polypeptide binding]; other site 484021006495 catalytic residues [active] 484021006496 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 484021006497 heat shock protein HspQ; Provisional; Region: PRK14129 484021006498 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 484021006499 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 484021006500 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 484021006501 putative RNA binding site [nucleotide binding]; other site 484021006502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021006503 S-adenosylmethionine binding site [chemical binding]; other site 484021006504 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 484021006505 substrate binding site [chemical binding]; other site 484021006506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021006507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021006508 acylphosphatase; Provisional; Region: PRK14426 484021006509 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 484021006510 sulfur transfer protein TusE; Provisional; Region: PRK11508 484021006511 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 484021006512 YccA-like proteins; Region: YccA_like; cd10433 484021006513 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 484021006514 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 484021006515 peptide binding site [polypeptide binding]; other site 484021006516 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 484021006517 homodimer interface [polypeptide binding]; other site 484021006518 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 484021006519 active site pocket [active] 484021006520 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484021006521 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 484021006522 anti sigma factor interaction site; other site 484021006523 regulatory phosphorylation site [posttranslational modification]; other site 484021006524 phage resistance protein; Provisional; Region: PRK10551 484021006525 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 484021006526 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021006527 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 484021006528 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 484021006529 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 484021006530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006531 dimer interface [polypeptide binding]; other site 484021006532 conserved gate region; other site 484021006533 ABC-ATPase subunit interface; other site 484021006534 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 484021006535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006536 dimer interface [polypeptide binding]; other site 484021006537 conserved gate region; other site 484021006538 putative PBP binding loops; other site 484021006539 ABC-ATPase subunit interface; other site 484021006540 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 484021006541 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 484021006542 Walker A/P-loop; other site 484021006543 ATP binding site [chemical binding]; other site 484021006544 Q-loop/lid; other site 484021006545 ABC transporter signature motif; other site 484021006546 Walker B; other site 484021006547 D-loop; other site 484021006548 H-loop/switch region; other site 484021006549 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021006550 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021006551 metal binding site [ion binding]; metal-binding site 484021006552 active site 484021006553 I-site; other site 484021006554 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021006555 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021006556 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 484021006557 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 484021006558 active site 484021006559 P-loop; other site 484021006560 phosphorylation site [posttranslational modification] 484021006561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021006562 FeS/SAM binding site; other site 484021006563 pyruvate formate lyase II activase; Provisional; Region: PRK10076 484021006564 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 484021006565 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 484021006566 dimer interface [polypeptide binding]; other site 484021006567 active site 484021006568 glycine loop; other site 484021006569 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 484021006570 active site 484021006571 P-loop; other site 484021006572 phosphorylation site [posttranslational modification] 484021006573 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 484021006574 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 484021006575 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484021006576 dimerization domain swap beta strand [polypeptide binding]; other site 484021006577 regulatory protein interface [polypeptide binding]; other site 484021006578 active site 484021006579 regulatory phosphorylation site [posttranslational modification]; other site 484021006580 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 484021006581 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 484021006582 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484021006583 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 484021006584 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021006585 active site 484021006586 phosphorylation site [posttranslational modification] 484021006587 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 484021006588 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 484021006589 FMN-binding pocket [chemical binding]; other site 484021006590 flavin binding motif; other site 484021006591 phosphate binding motif [ion binding]; other site 484021006592 beta-alpha-beta structure motif; other site 484021006593 NAD binding pocket [chemical binding]; other site 484021006594 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021006595 catalytic loop [active] 484021006596 iron binding site [ion binding]; other site 484021006597 succinic semialdehyde dehydrogenase; Region: PLN02278 484021006598 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 484021006599 tetramerization interface [polypeptide binding]; other site 484021006600 NAD(P) binding site [chemical binding]; other site 484021006601 catalytic residues [active] 484021006602 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 484021006603 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 484021006604 [2Fe-2S] cluster binding site [ion binding]; other site 484021006605 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 484021006606 putative alpha subunit interface [polypeptide binding]; other site 484021006607 putative active site [active] 484021006608 putative substrate binding site [chemical binding]; other site 484021006609 Fe binding site [ion binding]; other site 484021006610 putative transporter; Provisional; Region: PRK09950 484021006611 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 484021006612 tartrate dehydrogenase; Region: TTC; TIGR02089 484021006613 transcriptional activator TtdR; Provisional; Region: PRK09801 484021006614 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021006615 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 484021006616 putative effector binding pocket; other site 484021006617 putative dimerization interface [polypeptide binding]; other site 484021006618 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 484021006619 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 484021006620 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 484021006621 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 484021006622 NAD(P) binding site [chemical binding]; other site 484021006623 catalytic residues [active] 484021006624 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 484021006625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021006626 non-specific DNA binding site [nucleotide binding]; other site 484021006627 salt bridge; other site 484021006628 sequence-specific DNA binding site [nucleotide binding]; other site 484021006629 Cupin domain; Region: Cupin_2; pfam07883 484021006630 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 484021006631 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 484021006632 catalytic triad [active] 484021006633 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 484021006634 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 484021006635 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484021006636 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 484021006637 classical (c) SDRs; Region: SDR_c; cd05233 484021006638 NAD(P) binding site [chemical binding]; other site 484021006639 active site 484021006640 Predicted transcriptional regulators [Transcription]; Region: COG1733 484021006641 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 484021006642 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 484021006643 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 484021006644 catalytic core [active] 484021006645 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 484021006646 hypothetical protein; Provisional; Region: PRK10174 484021006647 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 484021006648 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484021006649 General stress protein [General function prediction only]; Region: GsiB; COG3729 484021006650 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021006651 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 484021006652 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 484021006653 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 484021006654 putative FMN binding site [chemical binding]; other site 484021006655 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 484021006656 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484021006657 homotrimer interaction site [polypeptide binding]; other site 484021006658 putative active site [active] 484021006659 Isochorismatase family; Region: Isochorismatase; pfam00857 484021006660 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 484021006661 catalytic triad [active] 484021006662 conserved cis-peptide bond; other site 484021006663 pyrimidine utilization protein A; Region: RutA; TIGR03612 484021006664 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 484021006665 active site 484021006666 dimer interface [polypeptide binding]; other site 484021006667 non-prolyl cis peptide bond; other site 484021006668 insertion regions; other site 484021006669 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 484021006670 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 484021006671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021006672 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 484021006673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 484021006674 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 484021006675 Predicted transcriptional regulator [Transcription]; Region: COG3905 484021006676 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 484021006677 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 484021006678 Glutamate binding site [chemical binding]; other site 484021006679 NAD binding site [chemical binding]; other site 484021006680 catalytic residues [active] 484021006681 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 484021006682 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 484021006683 Na binding site [ion binding]; other site 484021006684 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 484021006685 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484021006686 Nucleoside recognition; Region: Gate; pfam07670 484021006687 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484021006688 FTR1 family protein; Region: TIGR00145 484021006689 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 484021006690 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 484021006691 Imelysin; Region: Peptidase_M75; pfam09375 484021006692 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 484021006693 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 484021006694 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 484021006695 hypothetical protein; Provisional; Region: PRK10536 484021006696 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 484021006697 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 484021006698 catalytic residues [active] 484021006699 hinge region; other site 484021006700 alpha helical domain; other site 484021006701 Isochorismatase family; Region: Isochorismatase; pfam00857 484021006702 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 484021006703 catalytic triad [active] 484021006704 dimer interface [polypeptide binding]; other site 484021006705 conserved cis-peptide bond; other site 484021006706 Pirin-related protein [General function prediction only]; Region: COG1741 484021006707 Pirin; Region: Pirin; pfam02678 484021006708 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 484021006709 LysR family transcriptional regulator; Provisional; Region: PRK14997 484021006710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021006711 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 484021006712 putative effector binding pocket; other site 484021006713 putative dimerization interface [polypeptide binding]; other site 484021006714 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 484021006715 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 484021006716 putative ligand binding site [chemical binding]; other site 484021006717 NAD binding site [chemical binding]; other site 484021006718 dimerization interface [polypeptide binding]; other site 484021006719 catalytic site [active] 484021006720 putative hydrolase; Validated; Region: PRK09248 484021006721 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 484021006722 active site 484021006723 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 484021006724 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 484021006725 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 484021006726 putative ADP-ribose binding site [chemical binding]; other site 484021006727 putative active site [active] 484021006728 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 484021006729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021006730 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 484021006731 Acyltransferase family; Region: Acyl_transf_3; pfam01757 484021006732 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 484021006733 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 484021006734 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484021006735 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 484021006736 Ligand binding site; other site 484021006737 DXD motif; other site 484021006738 lipoprotein; Provisional; Region: PRK10175 484021006739 secY/secA suppressor protein; Provisional; Region: PRK11467 484021006740 drug efflux system protein MdtG; Provisional; Region: PRK09874 484021006741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021006742 putative substrate translocation pore; other site 484021006743 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 484021006744 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484021006745 putative acyl-acceptor binding pocket; other site 484021006746 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 484021006747 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 484021006748 active site residue [active] 484021006749 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 484021006750 hydroxyglutarate oxidase; Provisional; Region: PRK11728 484021006751 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 484021006752 DNA damage-inducible protein I; Provisional; Region: PRK10597 484021006753 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 484021006754 active site 484021006755 substrate binding pocket [chemical binding]; other site 484021006756 dimer interface [polypeptide binding]; other site 484021006757 lipoprotein; Provisional; Region: PRK10598 484021006758 multidrug resistance protein MdtH; Provisional; Region: PRK11646 484021006759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021006760 putative substrate translocation pore; other site 484021006761 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 484021006762 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484021006763 hypothetical protein; Provisional; Region: PRK11239 484021006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 484021006765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021006766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021006767 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 484021006768 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 484021006769 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021006770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021006771 putative substrate translocation pore; other site 484021006772 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021006773 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021006774 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021006775 putative effector binding pocket; other site 484021006776 dimerization interface [polypeptide binding]; other site 484021006777 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 484021006778 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484021006779 homodimer interface [polypeptide binding]; other site 484021006780 oligonucleotide binding site [chemical binding]; other site 484021006781 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 484021006782 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 484021006783 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021006784 RNA binding surface [nucleotide binding]; other site 484021006785 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484021006786 active site 484021006787 Maf-like protein; Region: Maf; pfam02545 484021006788 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 484021006789 active site 484021006790 dimer interface [polypeptide binding]; other site 484021006791 hypothetical protein; Provisional; Region: PRK11193 484021006792 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 484021006793 putative phosphate acyltransferase; Provisional; Region: PRK05331 484021006794 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 484021006795 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 484021006796 dimer interface [polypeptide binding]; other site 484021006797 active site 484021006798 CoA binding pocket [chemical binding]; other site 484021006799 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 484021006800 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484021006801 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484021006802 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 484021006803 NAD(P) binding site [chemical binding]; other site 484021006804 homotetramer interface [polypeptide binding]; other site 484021006805 homodimer interface [polypeptide binding]; other site 484021006806 active site 484021006807 acyl carrier protein; Provisional; Region: acpP; PRK00982 484021006808 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 484021006809 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484021006810 dimer interface [polypeptide binding]; other site 484021006811 active site 484021006812 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 484021006813 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 484021006814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021006815 catalytic residue [active] 484021006816 conserved hypothetical protein, YceG family; Region: TIGR00247 484021006817 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 484021006818 dimerization interface [polypeptide binding]; other site 484021006819 thymidylate kinase; Validated; Region: tmk; PRK00698 484021006820 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 484021006821 TMP-binding site; other site 484021006822 ATP-binding site [chemical binding]; other site 484021006823 DNA polymerase III subunit delta'; Validated; Region: PRK07993 484021006824 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 484021006825 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484021006826 active site 484021006827 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 484021006828 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021006829 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021006830 active site turn [active] 484021006831 phosphorylation site [posttranslational modification] 484021006832 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 484021006833 nucleotide binding site/active site [active] 484021006834 HIT family signature motif; other site 484021006835 catalytic residue [active] 484021006836 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 484021006837 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 484021006838 putative dimer interface [polypeptide binding]; other site 484021006839 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 484021006840 thiamine kinase; Region: ycfN_thiK; TIGR02721 484021006841 thiamine kinase; Provisional; Region: thiK; PRK10271 484021006842 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 484021006843 beta-hexosaminidase; Provisional; Region: PRK05337 484021006844 hypothetical protein; Provisional; Region: PRK04940 484021006845 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 484021006846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021006847 hypothetical protein; Provisional; Region: PRK11280 484021006848 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 484021006849 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021006850 N-terminal plug; other site 484021006851 ligand-binding site [chemical binding]; other site 484021006852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021006853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021006854 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021006855 L,D-transpeptidase; Provisional; Region: PRK10190 484021006856 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021006857 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484021006858 transcription-repair coupling factor; Provisional; Region: PRK10689 484021006859 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 484021006860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021006861 ATP binding site [chemical binding]; other site 484021006862 putative Mg++ binding site [ion binding]; other site 484021006863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021006864 nucleotide binding region [chemical binding]; other site 484021006865 ATP-binding site [chemical binding]; other site 484021006866 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 484021006867 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 484021006868 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484021006869 FtsX-like permease family; Region: FtsX; pfam02687 484021006870 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 484021006871 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484021006872 Walker A/P-loop; other site 484021006873 ATP binding site [chemical binding]; other site 484021006874 Q-loop/lid; other site 484021006875 ABC transporter signature motif; other site 484021006876 Walker B; other site 484021006877 D-loop; other site 484021006878 H-loop/switch region; other site 484021006879 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 484021006880 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484021006881 FtsX-like permease family; Region: FtsX; pfam02687 484021006882 fructokinase; Reviewed; Region: PRK09557 484021006883 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021006884 nucleotide binding site [chemical binding]; other site 484021006885 NAD-dependent deacetylase; Provisional; Region: PRK00481 484021006886 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 484021006887 NAD+ binding site [chemical binding]; other site 484021006888 substrate binding site [chemical binding]; other site 484021006889 Zn binding site [ion binding]; other site 484021006890 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 484021006891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484021006892 DNA binding residues [nucleotide binding] 484021006893 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 484021006894 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 484021006895 substrate binding site [chemical binding]; other site 484021006896 dimer interface [polypeptide binding]; other site 484021006897 triosephosphate isomerase; Provisional; Region: PRK14565 484021006898 catalytic triad [active] 484021006899 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 484021006900 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 484021006901 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 484021006902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 484021006903 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 484021006904 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 484021006905 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 484021006906 transaldolase-like protein; Provisional; Region: PTZ00411 484021006907 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 484021006908 active site 484021006909 dimer interface [polypeptide binding]; other site 484021006910 catalytic residue [active] 484021006911 transketolase; Reviewed; Region: PRK12753 484021006912 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484021006913 TPP-binding site [chemical binding]; other site 484021006914 dimer interface [polypeptide binding]; other site 484021006915 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484021006916 PYR/PP interface [polypeptide binding]; other site 484021006917 dimer interface [polypeptide binding]; other site 484021006918 TPP binding site [chemical binding]; other site 484021006919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021006920 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 484021006921 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 484021006922 dimer interface [polypeptide binding]; other site 484021006923 acyl-activating enzyme (AAE) consensus motif; other site 484021006924 putative active site [active] 484021006925 AMP binding site [chemical binding]; other site 484021006926 putative CoA binding site [chemical binding]; other site 484021006927 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 484021006928 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484021006929 NAD(P) binding site [chemical binding]; other site 484021006930 catalytic residues [active] 484021006931 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 484021006932 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 484021006933 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484021006934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006935 dimer interface [polypeptide binding]; other site 484021006936 conserved gate region; other site 484021006937 putative PBP binding loops; other site 484021006938 ABC-ATPase subunit interface; other site 484021006939 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484021006940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021006941 dimer interface [polypeptide binding]; other site 484021006942 conserved gate region; other site 484021006943 putative PBP binding loops; other site 484021006944 ABC-ATPase subunit interface; other site 484021006945 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 484021006946 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 484021006947 Walker A/P-loop; other site 484021006948 ATP binding site [chemical binding]; other site 484021006949 Q-loop/lid; other site 484021006950 ABC transporter signature motif; other site 484021006951 Walker B; other site 484021006952 D-loop; other site 484021006953 H-loop/switch region; other site 484021006954 TOBE domain; Region: TOBE_2; pfam08402 484021006955 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 484021006956 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 484021006957 metal binding site [ion binding]; metal-binding site 484021006958 dimer interface [polypeptide binding]; other site 484021006959 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021006960 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021006961 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021006962 putative transposase OrfB; Reviewed; Region: PHA02517 484021006963 HTH-like domain; Region: HTH_21; pfam13276 484021006964 Integrase core domain; Region: rve; pfam00665 484021006965 Integrase core domain; Region: rve_2; pfam13333 484021006966 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 484021006967 Uncharacterized conserved protein [Function unknown]; Region: COG2850 484021006968 sensor protein PhoQ; Provisional; Region: PRK10815 484021006969 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 484021006970 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 484021006971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021006972 ATP binding site [chemical binding]; other site 484021006973 Mg2+ binding site [ion binding]; other site 484021006974 G-X-G motif; other site 484021006975 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 484021006976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021006977 active site 484021006978 phosphorylation site [posttranslational modification] 484021006979 intermolecular recognition site; other site 484021006980 dimerization interface [polypeptide binding]; other site 484021006981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021006982 DNA binding site [nucleotide binding] 484021006983 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021006984 Helix-turn-helix domain; Region: HTH_18; pfam12833 484021006985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021006986 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 484021006987 adenylosuccinate lyase; Provisional; Region: PRK09285 484021006988 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 484021006989 tetramer interface [polypeptide binding]; other site 484021006990 active site 484021006991 putative lysogenization regulator; Reviewed; Region: PRK00218 484021006992 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 484021006993 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 484021006994 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 484021006995 nudix motif; other site 484021006996 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 484021006997 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 484021006998 probable active site [active] 484021006999 isocitrate dehydrogenase; Validated; Region: PRK07362 484021007000 isocitrate dehydrogenase; Reviewed; Region: PRK07006 484021007001 prophage lambda or CP-933X 484021007002 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 484021007003 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 484021007004 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 484021007005 dimer interface [polypeptide binding]; other site 484021007006 active site 484021007007 Int/Topo IB signature motif; other site 484021007008 Excisionase-like protein; Region: Exc; pfam07825 484021007009 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 484021007010 HD domain; Region: HD_3; cl17350 484021007011 Uncharacterized conserved protein (DUF2303); Region: DUF2303; pfam10065 484021007012 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 484021007013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021007014 non-specific DNA binding site [nucleotide binding]; other site 484021007015 salt bridge; other site 484021007016 sequence-specific DNA binding site [nucleotide binding]; other site 484021007017 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 484021007018 Catalytic site [active] 484021007019 Helix-turn-helix domain; Region: HTH_36; pfam13730 484021007020 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 484021007021 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 484021007022 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 484021007023 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 484021007024 cofactor binding site; other site 484021007025 DNA binding site [nucleotide binding] 484021007026 substrate interaction site [chemical binding]; other site 484021007027 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 484021007028 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 484021007029 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 484021007030 KilA-N domain; Region: KilA-N; pfam04383 484021007031 Protein of unknown function (DUF968); Region: DUF968; pfam06147 484021007032 Antitermination protein; Region: Antiterm; pfam03589 484021007033 Antitermination protein; Region: Antiterm; pfam03589 484021007034 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 484021007035 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 484021007036 Protein of unknown function (DUF754); Region: DUF754; pfam05449 484021007037 Predicted chitinase [General function prediction only]; Region: COG3179 484021007038 YfbU domain; Region: YfbU; cl01137 484021007039 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021007040 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021007041 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 484021007042 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484021007043 putative acyl-acceptor binding pocket; other site 484021007044 leucine export protein LeuE; Provisional; Region: PRK10958 484021007045 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 484021007046 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 484021007047 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 484021007048 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021007049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021007050 metal binding site [ion binding]; metal-binding site 484021007051 active site 484021007052 I-site; other site 484021007053 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 484021007054 Domain of unknown function (DUF333); Region: DUF333; pfam03891 484021007055 Uncharacterized conserved protein [Function unknown]; Region: COG3189 484021007056 Uncharacterized conserved protein [Function unknown]; Region: COG1683 484021007057 hypothetical protein; Validated; Region: PRK06186 484021007058 conserved cys residue [active] 484021007059 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 484021007060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007061 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484021007062 Predicted membrane protein [Function unknown]; Region: COG2707 484021007063 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 484021007064 putative deacylase active site [active] 484021007065 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 484021007066 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484021007067 DinI-like family; Region: DinI; cl11630 484021007068 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 484021007069 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 484021007070 Catalytic site [active] 484021007071 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 484021007072 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 484021007073 active site 484021007074 DNA binding site [nucleotide binding] 484021007075 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 484021007076 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007077 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007078 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021007079 putative effector binding pocket; other site 484021007080 putative dimerization interface [polypeptide binding]; other site 484021007081 short chain dehydrogenase; Provisional; Region: PRK06500 484021007082 classical (c) SDRs; Region: SDR_c; cd05233 484021007083 NAD(P) binding site [chemical binding]; other site 484021007084 active site 484021007085 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021007086 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007087 putative substrate translocation pore; other site 484021007088 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007089 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007090 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021007091 dimerization interface [polypeptide binding]; other site 484021007092 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 484021007093 catalytic residues [active] 484021007094 dimer interface [polypeptide binding]; other site 484021007095 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 484021007096 hypothetical protein; Provisional; Region: PRK05325 484021007097 PrkA family serine protein kinase; Provisional; Region: PRK15455 484021007098 AAA ATPase domain; Region: AAA_16; pfam13191 484021007099 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021007100 Walker A motif; other site 484021007101 ATP binding site [chemical binding]; other site 484021007102 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 484021007103 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 484021007104 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021007105 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021007106 active site 484021007107 catalytic tetrad [active] 484021007108 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 484021007109 active site 484021007110 phosphate binding residues; other site 484021007111 catalytic residues [active] 484021007112 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 484021007113 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 484021007114 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 484021007115 methionine sulfoxide reductase B; Provisional; Region: PRK00222 484021007116 SelR domain; Region: SelR; pfam01641 484021007117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 484021007118 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 484021007119 active site 484021007120 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 484021007121 Glyco_18 domain; Region: Glyco_18; smart00636 484021007122 active site 484021007123 potential frameshift: common BLAST hit: gi|152969756|ref|YP_001334865.1| nicotinamidase/pyrazinamidase 484021007124 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 484021007125 conserved cis-peptide bond; other site 484021007126 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 484021007127 catalytic triad [active] 484021007128 metal binding site [ion binding]; metal-binding site 484021007129 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 484021007130 active site 484021007131 homodimer interface [polypeptide binding]; other site 484021007132 protease 4; Provisional; Region: PRK10949 484021007133 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 484021007134 tandem repeat interface [polypeptide binding]; other site 484021007135 oligomer interface [polypeptide binding]; other site 484021007136 active site residues [active] 484021007137 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 484021007138 tandem repeat interface [polypeptide binding]; other site 484021007139 oligomer interface [polypeptide binding]; other site 484021007140 active site residues [active] 484021007141 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 484021007142 putative FMN binding site [chemical binding]; other site 484021007143 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 484021007144 active site 484021007145 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484021007146 selenophosphate synthetase; Provisional; Region: PRK00943 484021007147 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 484021007148 dimerization interface [polypeptide binding]; other site 484021007149 putative ATP binding site [chemical binding]; other site 484021007150 DNA topoisomerase III; Provisional; Region: PRK07726 484021007151 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 484021007152 active site 484021007153 putative interdomain interaction site [polypeptide binding]; other site 484021007154 putative metal-binding site [ion binding]; other site 484021007155 putative nucleotide binding site [chemical binding]; other site 484021007156 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 484021007157 domain I; other site 484021007158 DNA binding groove [nucleotide binding] 484021007159 phosphate binding site [ion binding]; other site 484021007160 domain II; other site 484021007161 domain III; other site 484021007162 nucleotide binding site [chemical binding]; other site 484021007163 catalytic site [active] 484021007164 domain IV; other site 484021007165 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 484021007166 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 484021007167 NAD(P) binding site [chemical binding]; other site 484021007168 glutamate dehydrogenase; Provisional; Region: PRK09414 484021007169 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 484021007170 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 484021007171 NAD(P) binding site [chemical binding]; other site 484021007172 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 484021007173 active site 484021007174 8-oxo-dGMP binding site [chemical binding]; other site 484021007175 nudix motif; other site 484021007176 metal binding site [ion binding]; metal-binding site 484021007177 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484021007178 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 484021007179 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 484021007180 active site residue [active] 484021007181 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 484021007182 active site residue [active] 484021007183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021007184 Walker A/P-loop; other site 484021007185 ATP binding site [chemical binding]; other site 484021007186 Q-loop/lid; other site 484021007187 ABC transporter signature motif; other site 484021007188 Walker B; other site 484021007189 D-loop; other site 484021007190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021007191 ABC-ATPase subunit interface; other site 484021007192 putative PBP binding loops; other site 484021007193 hypothetical protein; Provisional; Region: PRK11622 484021007194 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 484021007195 Uncharacterized conserved protein [Function unknown]; Region: COG2128 484021007196 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 484021007197 Uncharacterized conserved protein [Function unknown]; Region: COG0398 484021007198 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484021007199 Uncharacterized conserved protein [Function unknown]; Region: COG0398 484021007200 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484021007201 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 484021007202 putative catalytic site [active] 484021007203 putative phosphate binding site [ion binding]; other site 484021007204 active site 484021007205 metal binding site A [ion binding]; metal-binding site 484021007206 DNA binding site [nucleotide binding] 484021007207 putative AP binding site [nucleotide binding]; other site 484021007208 putative metal binding site B [ion binding]; other site 484021007209 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 484021007210 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021007211 inhibitor-cofactor binding pocket; inhibition site 484021007212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021007213 catalytic residue [active] 484021007214 arginine succinyltransferase; Provisional; Region: PRK10456 484021007215 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 484021007216 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 484021007217 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 484021007218 NAD(P) binding site [chemical binding]; other site 484021007219 catalytic residues [active] 484021007220 succinylarginine dihydrolase; Provisional; Region: PRK13281 484021007221 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 484021007222 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 484021007223 putative active site [active] 484021007224 Zn binding site [ion binding]; other site 484021007225 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 484021007226 dimer interface [polypeptide binding]; other site 484021007227 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 484021007228 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 484021007229 GIY-YIG motif/motif A; other site 484021007230 active site 484021007231 catalytic site [active] 484021007232 putative DNA binding site [nucleotide binding]; other site 484021007233 metal binding site [ion binding]; metal-binding site 484021007234 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 484021007235 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 484021007236 homodimer interface [polypeptide binding]; other site 484021007237 NAD binding pocket [chemical binding]; other site 484021007238 ATP binding pocket [chemical binding]; other site 484021007239 Mg binding site [ion binding]; other site 484021007240 active-site loop [active] 484021007241 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 484021007242 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484021007243 active site 484021007244 P-loop; other site 484021007245 phosphorylation site [posttranslational modification] 484021007246 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 484021007247 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021007248 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 484021007249 methionine cluster; other site 484021007250 active site 484021007251 phosphorylation site [posttranslational modification] 484021007252 metal binding site [ion binding]; metal-binding site 484021007253 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 484021007254 Cupin domain; Region: Cupin_2; pfam07883 484021007255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021007256 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 484021007257 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 484021007258 NAD binding site [chemical binding]; other site 484021007259 sugar binding site [chemical binding]; other site 484021007260 divalent metal binding site [ion binding]; other site 484021007261 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021007262 dimer interface [polypeptide binding]; other site 484021007263 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 484021007264 putative active site [active] 484021007265 YdjC motif; other site 484021007266 Mg binding site [ion binding]; other site 484021007267 putative homodimer interface [polypeptide binding]; other site 484021007268 potential frameshift: common BLAST hit: gi|152969790|ref|YP_001334899.1| hydroperoxidase II 484021007269 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 484021007270 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 484021007271 domain interactions; other site 484021007272 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 484021007273 heme binding pocket [chemical binding]; other site 484021007274 cell division modulator; Provisional; Region: PRK10113 484021007275 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 484021007276 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484021007277 inner membrane protein; Provisional; Region: PRK11648 484021007278 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 484021007279 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 484021007280 NADP binding site [chemical binding]; other site 484021007281 homodimer interface [polypeptide binding]; other site 484021007282 active site 484021007283 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 484021007284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021007285 motif II; other site 484021007286 YniB-like protein; Region: YniB; pfam14002 484021007287 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 484021007288 outer membrane receptor FepA; Provisional; Region: PRK13528 484021007289 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021007290 N-terminal plug; other site 484021007291 ligand-binding site [chemical binding]; other site 484021007292 intracellular septation protein A; Reviewed; Region: PRK00259 484021007293 hypothetical protein; Provisional; Region: PRK02868 484021007294 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 484021007295 outer membrane protein W; Provisional; Region: PRK10959 484021007296 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 484021007297 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 484021007298 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021007299 N-terminal plug; other site 484021007300 ligand-binding site [chemical binding]; other site 484021007301 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021007302 C factor cell-cell signaling protein; Provisional; Region: PRK09009 484021007303 NAD(P) binding site [chemical binding]; other site 484021007304 active site 484021007305 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021007306 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 484021007307 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 484021007308 putative NAD(P) binding site [chemical binding]; other site 484021007309 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021007310 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021007311 putative DNA binding site [nucleotide binding]; other site 484021007312 putative Zn2+ binding site [ion binding]; other site 484021007313 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 484021007314 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007315 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 484021007316 dimerization interface [polypeptide binding]; other site 484021007317 substrate binding pocket [chemical binding]; other site 484021007318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007319 D-galactonate transporter; Region: 2A0114; TIGR00893 484021007320 putative substrate translocation pore; other site 484021007321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007322 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 484021007323 tartrate dehydrogenase; Region: TTC; TIGR02089 484021007324 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 484021007325 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 484021007326 MOFRL family; Region: MOFRL; pfam05161 484021007327 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 484021007328 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 484021007329 substrate binding site [chemical binding]; other site 484021007330 active site 484021007331 catalytic residues [active] 484021007332 heterodimer interface [polypeptide binding]; other site 484021007333 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 484021007334 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 484021007335 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021007336 catalytic residue [active] 484021007337 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 484021007338 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 484021007339 active site 484021007340 ribulose/triose binding site [chemical binding]; other site 484021007341 phosphate binding site [ion binding]; other site 484021007342 substrate (anthranilate) binding pocket [chemical binding]; other site 484021007343 product (indole) binding pocket [chemical binding]; other site 484021007344 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 484021007345 active site 484021007346 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 484021007347 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484021007348 glutamine binding [chemical binding]; other site 484021007349 catalytic triad [active] 484021007350 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 484021007351 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 484021007352 anthranilate synthase component I; Provisional; Region: PRK13564 484021007353 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 484021007354 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 484021007355 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 484021007356 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 484021007357 active site 484021007358 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 484021007359 hypothetical protein; Provisional; Region: PRK11630 484021007360 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484021007361 EamA-like transporter family; Region: EamA; pfam00892 484021007362 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484021007363 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007364 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021007365 dimerization interface [polypeptide binding]; other site 484021007366 substrate binding pocket [chemical binding]; other site 484021007367 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 484021007368 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021007369 RNA binding surface [nucleotide binding]; other site 484021007370 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 484021007371 probable active site [active] 484021007372 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 484021007373 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 484021007374 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 484021007375 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 484021007376 NADP binding site [chemical binding]; other site 484021007377 homodimer interface [polypeptide binding]; other site 484021007378 active site 484021007379 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 484021007380 putative inner membrane peptidase; Provisional; Region: PRK11778 484021007381 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 484021007382 tandem repeat interface [polypeptide binding]; other site 484021007383 oligomer interface [polypeptide binding]; other site 484021007384 active site residues [active] 484021007385 hypothetical protein; Provisional; Region: PRK11037 484021007386 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 484021007387 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 484021007388 active site 484021007389 interdomain interaction site; other site 484021007390 putative metal-binding site [ion binding]; other site 484021007391 nucleotide binding site [chemical binding]; other site 484021007392 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 484021007393 domain I; other site 484021007394 DNA binding groove [nucleotide binding] 484021007395 phosphate binding site [ion binding]; other site 484021007396 domain II; other site 484021007397 domain III; other site 484021007398 nucleotide binding site [chemical binding]; other site 484021007399 catalytic site [active] 484021007400 domain IV; other site 484021007401 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484021007402 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484021007403 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 484021007404 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 484021007405 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 484021007406 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007407 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 484021007408 substrate binding site [chemical binding]; other site 484021007409 putative dimerization interface [polypeptide binding]; other site 484021007410 aconitate hydratase; Validated; Region: PRK09277 484021007411 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 484021007412 substrate binding site [chemical binding]; other site 484021007413 ligand binding site [chemical binding]; other site 484021007414 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 484021007415 substrate binding site [chemical binding]; other site 484021007416 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 484021007417 dimerization interface [polypeptide binding]; other site 484021007418 active site 484021007419 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484021007420 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 484021007421 active site 484021007422 Predicted membrane protein [Function unknown]; Region: COG3771 484021007423 tetratricopeptide repeat protein; Provisional; Region: PRK11788 484021007424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 484021007425 binding surface 484021007426 TPR motif; other site 484021007427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021007428 binding surface 484021007429 TPR motif; other site 484021007430 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 484021007431 active site 484021007432 dimer interface [polypeptide binding]; other site 484021007433 translation initiation factor Sui1; Validated; Region: PRK06824 484021007434 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 484021007435 putative rRNA binding site [nucleotide binding]; other site 484021007436 lipoprotein; Provisional; Region: PRK10540 484021007437 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021007438 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021007439 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021007440 hypothetical protein; Provisional; Region: PRK13658 484021007441 exoribonuclease II; Provisional; Region: PRK05054 484021007442 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 484021007443 RNB domain; Region: RNB; pfam00773 484021007444 S1 RNA binding domain; Region: S1; pfam00575 484021007445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950; cl17731 484021007446 Uncharacterized conserved protein [Function unknown]; Region: COG2128 484021007447 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 484021007448 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 484021007449 NAD binding site [chemical binding]; other site 484021007450 homotetramer interface [polypeptide binding]; other site 484021007451 homodimer interface [polypeptide binding]; other site 484021007452 substrate binding site [chemical binding]; other site 484021007453 active site 484021007454 HutD; Region: HutD; pfam05962 484021007455 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 484021007456 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 484021007457 Na binding site [ion binding]; other site 484021007458 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 484021007459 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021007460 Walker A/P-loop; other site 484021007461 ATP binding site [chemical binding]; other site 484021007462 Q-loop/lid; other site 484021007463 ABC transporter signature motif; other site 484021007464 Walker B; other site 484021007465 D-loop; other site 484021007466 H-loop/switch region; other site 484021007467 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 484021007468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021007469 Walker A/P-loop; other site 484021007470 ATP binding site [chemical binding]; other site 484021007471 Q-loop/lid; other site 484021007472 ABC transporter signature motif; other site 484021007473 Walker B; other site 484021007474 D-loop; other site 484021007475 H-loop/switch region; other site 484021007476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021007477 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 484021007478 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021007479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021007480 dimer interface [polypeptide binding]; other site 484021007481 conserved gate region; other site 484021007482 putative PBP binding loops; other site 484021007483 ABC-ATPase subunit interface; other site 484021007484 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 484021007485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021007486 dimer interface [polypeptide binding]; other site 484021007487 conserved gate region; other site 484021007488 putative PBP binding loops; other site 484021007489 ABC-ATPase subunit interface; other site 484021007490 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 484021007491 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 484021007492 peptide binding site [polypeptide binding]; other site 484021007493 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 484021007494 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484021007495 putative NAD(P) binding site [chemical binding]; other site 484021007496 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021007497 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021007498 salt bridge; other site 484021007499 non-specific DNA binding site [nucleotide binding]; other site 484021007500 sequence-specific DNA binding site [nucleotide binding]; other site 484021007501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021007502 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021007503 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021007504 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 484021007505 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484021007506 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 484021007507 metal binding site [ion binding]; metal-binding site 484021007508 putative dimer interface [polypeptide binding]; other site 484021007509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021007510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007511 putative substrate translocation pore; other site 484021007512 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 484021007513 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021007514 Walker A motif; other site 484021007515 ATP binding site [chemical binding]; other site 484021007516 Walker B motif; other site 484021007517 arginine finger; other site 484021007518 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021007519 phage shock protein PspA; Provisional; Region: PRK10698 484021007520 phage shock protein B; Provisional; Region: pspB; PRK09458 484021007521 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 484021007522 phage shock protein C; Region: phageshock_pspC; TIGR02978 484021007523 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 484021007524 Predicted ATPase [General function prediction only]; Region: COG3106 484021007525 hypothetical protein; Provisional; Region: PRK05415 484021007526 Domain of unknown function (DUF697); Region: DUF697; cl12064 484021007527 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 484021007528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007529 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021007530 dimerization interface [polypeptide binding]; other site 484021007531 substrate binding pocket [chemical binding]; other site 484021007532 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 484021007533 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 484021007534 NAD binding site [chemical binding]; other site 484021007535 sugar binding site [chemical binding]; other site 484021007536 divalent metal binding site [ion binding]; other site 484021007537 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021007538 dimer interface [polypeptide binding]; other site 484021007539 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 484021007540 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 484021007541 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021007542 putative active site [active] 484021007543 heme pocket [chemical binding]; other site 484021007544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021007545 Walker A motif; other site 484021007546 ATP binding site [chemical binding]; other site 484021007547 Walker B motif; other site 484021007548 arginine finger; other site 484021007549 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 484021007550 Putative ammonia monooxygenase; Region: AmoA; pfam05145 484021007551 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 484021007552 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 484021007553 dimer interface [polypeptide binding]; other site 484021007554 catalytic triad [active] 484021007555 peroxidatic and resolving cysteines [active] 484021007556 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 484021007557 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 484021007558 active site 484021007559 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 484021007560 putative active site [active] 484021007561 Zn binding site [ion binding]; other site 484021007562 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 484021007563 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 484021007564 peptide binding site [polypeptide binding]; other site 484021007565 conjugative transfer region protein, TIGR03748 family; Region: conj_PilL 484021007566 Protein of unknown function (DUF3577); Region: DUF3577; pfam12101 484021007567 Protein of unknown function (DUF770); Region: DUF770; pfam05591 484021007568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 484021007569 PAAR motif; Region: PAAR_motif; pfam05488 484021007570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007572 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 484021007573 putative effector binding pocket; other site 484021007574 putative dimerization interface [polypeptide binding]; other site 484021007575 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 484021007576 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 484021007577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007578 putative substrate translocation pore; other site 484021007579 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021007580 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021007581 active site 484021007582 catalytic tetrad [active] 484021007583 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 484021007584 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 484021007585 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 484021007586 PAS fold; Region: PAS_7; pfam12860 484021007587 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021007588 PAS fold; Region: PAS_3; pfam08447 484021007589 putative active site [active] 484021007590 heme pocket [chemical binding]; other site 484021007591 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021007592 dimer interface [polypeptide binding]; other site 484021007593 phosphorylation site [posttranslational modification] 484021007594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021007595 ATP binding site [chemical binding]; other site 484021007596 Mg2+ binding site [ion binding]; other site 484021007597 G-X-G motif; other site 484021007598 Response regulator receiver domain; Region: Response_reg; pfam00072 484021007599 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021007600 active site 484021007601 phosphorylation site [posttranslational modification] 484021007602 intermolecular recognition site; other site 484021007603 dimerization interface [polypeptide binding]; other site 484021007604 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 484021007605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021007606 active site 484021007607 phosphorylation site [posttranslational modification] 484021007608 intermolecular recognition site; other site 484021007609 dimerization interface [polypeptide binding]; other site 484021007610 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 484021007611 putative binding surface; other site 484021007612 active site 484021007613 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 484021007614 heme-binding site [chemical binding]; other site 484021007615 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 484021007616 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 484021007617 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 484021007618 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 484021007619 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 484021007620 DXD motif; other site 484021007621 OpgC protein; Region: OpgC_C; cl17858 484021007622 Response regulator receiver domain; Region: Response_reg; pfam00072 484021007623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021007624 active site 484021007625 phosphorylation site [posttranslational modification] 484021007626 intermolecular recognition site; other site 484021007627 dimerization interface [polypeptide binding]; other site 484021007628 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 484021007629 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 484021007630 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 484021007631 anti sigma factor interaction site; other site 484021007632 regulatory phosphorylation site [posttranslational modification]; other site 484021007633 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 484021007634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 484021007635 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007636 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007637 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021007638 putative effector binding pocket; other site 484021007639 putative dimerization interface [polypeptide binding]; other site 484021007640 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484021007641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021007642 NAD(P) binding site [chemical binding]; other site 484021007643 active site 484021007644 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 484021007645 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021007646 Zn2+ binding site [ion binding]; other site 484021007647 Mg2+ binding site [ion binding]; other site 484021007648 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 484021007649 intracellular protease, PfpI family; Region: PfpI; TIGR01382 484021007650 conserved cys residue [active] 484021007651 Protein of unknown function (DUF770); Region: DUF770; pfam05591 484021007652 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 484021007653 Protein of unknown function (DUF877); Region: DUF877; pfam05943 484021007654 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 484021007655 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 484021007656 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 484021007657 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 484021007658 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484021007659 ligand binding site [chemical binding]; other site 484021007660 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 484021007661 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 484021007662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021007663 Walker A motif; other site 484021007664 ATP binding site [chemical binding]; other site 484021007665 Walker B motif; other site 484021007666 arginine finger; other site 484021007667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021007668 Walker A motif; other site 484021007669 ATP binding site [chemical binding]; other site 484021007670 Walker B motif; other site 484021007671 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 484021007672 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 484021007673 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 484021007674 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 484021007675 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 484021007676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4253 484021007677 virion protein; Provisional; Region: V; PHA02564 484021007678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021007679 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 484021007680 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021007681 TIGR02594 family protein; Region: TIGR02594 484021007682 Transposase; Region: HTH_Tnp_1; cl17663 484021007683 Transposase; Region: HTH_Tnp_1; pfam01527 484021007684 HTH-like domain; Region: HTH_21; pfam13276 484021007685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 484021007686 Integrase core domain; Region: rve; pfam00665 484021007687 Integrase core domain; Region: rve_3; pfam13683 484021007688 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021007689 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 484021007690 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021007691 TIGR02594 family protein; Region: TIGR02594 484021007692 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 484021007693 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 484021007694 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 484021007695 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 484021007696 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 484021007697 PAAR motif; Region: PAAR_motif; pfam05488 484021007698 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 484021007699 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 484021007700 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 484021007701 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 484021007702 oxidoreductase; Provisional; Region: PRK12742 484021007703 classical (c) SDRs; Region: SDR_c; cd05233 484021007704 NAD(P) binding site [chemical binding]; other site 484021007705 active site 484021007706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021007707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021007708 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 484021007709 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021007710 NAD(P) binding site [chemical binding]; other site 484021007711 active site 484021007712 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 484021007713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021007714 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021007715 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021007716 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 484021007717 NmrA-like family; Region: NmrA; pfam05368 484021007718 NAD(P) binding site [chemical binding]; other site 484021007719 active site lysine 484021007720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007722 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021007723 putative effector binding pocket; other site 484021007724 putative dimerization interface [polypeptide binding]; other site 484021007725 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007726 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007727 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 484021007728 putative substrate binding pocket [chemical binding]; other site 484021007729 putative dimerization interface [polypeptide binding]; other site 484021007730 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484021007731 NmrA-like family; Region: NmrA; pfam05368 484021007732 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 484021007733 NADP binding site [chemical binding]; other site 484021007734 active site 484021007735 regulatory binding site [polypeptide binding]; other site 484021007736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021007737 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 484021007738 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 484021007739 putative NAD(P) binding site [chemical binding]; other site 484021007740 transaminase; Reviewed; Region: PRK08068 484021007741 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021007742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021007743 homodimer interface [polypeptide binding]; other site 484021007744 catalytic residue [active] 484021007745 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 484021007746 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 484021007747 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 484021007748 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 484021007749 Walker A/P-loop; other site 484021007750 ATP binding site [chemical binding]; other site 484021007751 Q-loop/lid; other site 484021007752 ABC transporter signature motif; other site 484021007753 Walker B; other site 484021007754 D-loop; other site 484021007755 H-loop/switch region; other site 484021007756 NIL domain; Region: NIL; pfam09383 484021007757 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 484021007758 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 484021007759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021007760 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021007761 homodimer interface [polypeptide binding]; other site 484021007762 catalytic residue [active] 484021007763 Uncharacterized conserved protein [Function unknown]; Region: COG1284 484021007764 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 484021007765 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 484021007766 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 484021007767 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 484021007768 putative DNA binding site [nucleotide binding]; other site 484021007769 putative Zn2+ binding site [ion binding]; other site 484021007770 AsnC family; Region: AsnC_trans_reg; pfam01037 484021007771 aromatic amino acid transporter; Provisional; Region: PRK10238 484021007772 putative oxidoreductase; Provisional; Region: PRK11579 484021007773 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021007774 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021007775 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021007776 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021007777 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021007778 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 484021007779 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 484021007780 Cl binding site [ion binding]; other site 484021007781 oligomer interface [polypeptide binding]; other site 484021007782 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 484021007783 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484021007784 ATP binding site [chemical binding]; other site 484021007785 Mg++ binding site [ion binding]; other site 484021007786 motif III; other site 484021007787 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021007788 nucleotide binding region [chemical binding]; other site 484021007789 ATP-binding site [chemical binding]; other site 484021007790 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 484021007791 putative RNA binding site [nucleotide binding]; other site 484021007792 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 484021007793 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 484021007794 Ligand Binding Site [chemical binding]; other site 484021007795 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021007796 Ligand Binding Site [chemical binding]; other site 484021007797 KTSC domain; Region: KTSC; pfam13619 484021007798 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 484021007799 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 484021007800 trimer interface [polypeptide binding]; other site 484021007801 eyelet of channel; other site 484021007802 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 484021007803 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 484021007804 dimer interface [polypeptide binding]; other site 484021007805 PYR/PP interface [polypeptide binding]; other site 484021007806 TPP binding site [chemical binding]; other site 484021007807 substrate binding site [chemical binding]; other site 484021007808 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 484021007809 Domain of unknown function; Region: EKR; pfam10371 484021007810 4Fe-4S binding domain; Region: Fer4_6; pfam12837 484021007811 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 484021007812 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 484021007813 TPP-binding site [chemical binding]; other site 484021007814 dimer interface [polypeptide binding]; other site 484021007815 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 484021007816 Domain of unknown function (DUF333); Region: DUF333; pfam03891 484021007817 META domain; Region: META; cl01245 484021007818 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 484021007819 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 484021007820 putative ligand binding site [chemical binding]; other site 484021007821 putative NAD binding site [chemical binding]; other site 484021007822 catalytic site [active] 484021007823 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484021007824 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484021007825 hypothetical protein; Provisional; Region: PRK10695 484021007826 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 484021007827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 484021007828 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 484021007829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021007830 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484021007831 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484021007832 NAD(P) binding site [chemical binding]; other site 484021007833 catalytic residues [active] 484021007834 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 484021007835 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 484021007836 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 484021007837 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 484021007838 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 484021007839 NADP binding site [chemical binding]; other site 484021007840 dimer interface [polypeptide binding]; other site 484021007841 tyramine oxidase; Provisional; Region: tynA; PRK14696 484021007842 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 484021007843 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 484021007844 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 484021007845 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 484021007846 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 484021007847 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 484021007848 substrate binding site [chemical binding]; other site 484021007849 dimer interface [polypeptide binding]; other site 484021007850 NADP binding site [chemical binding]; other site 484021007851 catalytic residues [active] 484021007852 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 484021007853 substrate binding site [chemical binding]; other site 484021007854 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 484021007855 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 484021007856 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 484021007857 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 484021007858 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 484021007859 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 484021007860 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 484021007861 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 484021007862 FAD binding pocket [chemical binding]; other site 484021007863 FAD binding motif [chemical binding]; other site 484021007864 phosphate binding motif [ion binding]; other site 484021007865 beta-alpha-beta structure motif; other site 484021007866 NAD(p) ribose binding residues [chemical binding]; other site 484021007867 NAD binding pocket [chemical binding]; other site 484021007868 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 484021007869 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021007870 catalytic loop [active] 484021007871 iron binding site [ion binding]; other site 484021007872 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 484021007873 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 484021007874 substrate binding site [chemical binding]; other site 484021007875 oxyanion hole (OAH) forming residues; other site 484021007876 trimer interface [polypeptide binding]; other site 484021007877 enoyl-CoA hydratase; Provisional; Region: PRK08140 484021007878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 484021007879 substrate binding site [chemical binding]; other site 484021007880 oxyanion hole (OAH) forming residues; other site 484021007881 trimer interface [polypeptide binding]; other site 484021007882 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 484021007883 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 484021007884 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021007885 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021007886 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484021007887 CoenzymeA binding site [chemical binding]; other site 484021007888 subunit interaction site [polypeptide binding]; other site 484021007889 PHB binding site; other site 484021007890 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 484021007891 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021007892 dimer interface [polypeptide binding]; other site 484021007893 active site 484021007894 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 484021007895 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 484021007896 active site 484021007897 AMP binding site [chemical binding]; other site 484021007898 homodimer interface [polypeptide binding]; other site 484021007899 acyl-activating enzyme (AAE) consensus motif; other site 484021007900 CoA binding site [chemical binding]; other site 484021007901 PaaX-like protein; Region: PaaX; pfam07848 484021007902 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 484021007903 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 484021007904 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 484021007905 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 484021007906 putative trimer interface [polypeptide binding]; other site 484021007907 putative metal binding site [ion binding]; other site 484021007908 Uncharacterized conserved protein [Function unknown]; Region: COG3791 484021007909 azoreductase; Reviewed; Region: PRK00170 484021007910 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484021007911 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 484021007912 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021007913 ATP binding site [chemical binding]; other site 484021007914 putative Mg++ binding site [ion binding]; other site 484021007915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021007916 nucleotide binding region [chemical binding]; other site 484021007917 ATP-binding site [chemical binding]; other site 484021007918 Helicase associated domain (HA2); Region: HA2; pfam04408 484021007919 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 484021007920 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 484021007921 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 484021007922 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021007923 S-adenosylmethionine binding site [chemical binding]; other site 484021007924 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 484021007925 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 484021007926 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021007927 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021007928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007929 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021007930 putative substrate translocation pore; other site 484021007931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021007932 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 484021007933 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021007934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021007935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021007936 dimerization interface [polypeptide binding]; other site 484021007937 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021007938 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021007939 active site 484021007940 catalytic tetrad [active] 484021007941 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 484021007942 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 484021007943 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 484021007944 NAD(P) binding site [chemical binding]; other site 484021007945 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 484021007946 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021007947 inhibitor-cofactor binding pocket; inhibition site 484021007948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021007949 catalytic residue [active] 484021007950 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 484021007951 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 484021007952 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 484021007953 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 484021007954 NAD(P) binding site [chemical binding]; other site 484021007955 catalytic residues [active] 484021007956 succinylarginine dihydrolase; Provisional; Region: PRK13281 484021007957 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 484021007958 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 484021007959 active site 484021007960 Zn binding site [ion binding]; other site 484021007961 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 484021007962 shikimate transporter; Provisional; Region: PRK09952 484021007963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021007964 putative substrate translocation pore; other site 484021007965 Uncharacterized conserved protein [Function unknown]; Region: COG1434 484021007966 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484021007967 putative active site [active] 484021007968 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 484021007969 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484021007970 NAD binding site [chemical binding]; other site 484021007971 catalytic residues [active] 484021007972 substrate binding site [chemical binding]; other site 484021007973 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 484021007974 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 484021007975 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 484021007976 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 484021007977 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 484021007978 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 484021007979 CPxP motif; other site 484021007980 putative inner membrane protein; Provisional; Region: PRK11099 484021007981 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 484021007982 YdfZ protein; Region: YdfZ; pfam14001 484021007983 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 484021007984 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 484021007985 Cl binding site [ion binding]; other site 484021007986 oligomer interface [polypeptide binding]; other site 484021007987 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 484021007988 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021007989 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021007990 homodimer interface [polypeptide binding]; other site 484021007991 catalytic residue [active] 484021007992 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 484021007993 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 484021007994 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021007995 active site turn [active] 484021007996 phosphorylation site [posttranslational modification] 484021007997 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 484021007998 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021007999 DNA binding site [nucleotide binding] 484021008000 domain linker motif; other site 484021008001 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 484021008002 putative dimerization interface [polypeptide binding]; other site 484021008003 putative ligand binding site [chemical binding]; other site 484021008004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 484021008005 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 484021008006 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 484021008007 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 484021008008 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 484021008009 fumarate hydratase; Provisional; Region: PRK15389 484021008010 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 484021008011 Fumarase C-terminus; Region: Fumerase_C; pfam05683 484021008012 fumarate hydratase; Reviewed; Region: fumC; PRK00485 484021008013 Class II fumarases; Region: Fumarase_classII; cd01362 484021008014 active site 484021008015 tetramer interface [polypeptide binding]; other site 484021008016 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 484021008017 sensor protein RstB; Provisional; Region: PRK10604 484021008018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021008019 dimerization interface [polypeptide binding]; other site 484021008020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021008021 dimer interface [polypeptide binding]; other site 484021008022 phosphorylation site [posttranslational modification] 484021008023 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021008024 ATP binding site [chemical binding]; other site 484021008025 Mg2+ binding site [ion binding]; other site 484021008026 G-X-G motif; other site 484021008027 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 484021008028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021008029 active site 484021008030 phosphorylation site [posttranslational modification] 484021008031 intermolecular recognition site; other site 484021008032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021008033 DNA binding site [nucleotide binding] 484021008034 GlpM protein; Region: GlpM; pfam06942 484021008035 dihydromonapterin reductase; Provisional; Region: PRK06483 484021008036 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 484021008037 NADP binding site [chemical binding]; other site 484021008038 substrate binding pocket [chemical binding]; other site 484021008039 active site 484021008040 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 484021008041 Spore germination protein; Region: Spore_permease; cl17796 484021008042 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021008043 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021008044 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021008045 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 484021008046 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 484021008047 ligand binding site [chemical binding]; other site 484021008048 homodimer interface [polypeptide binding]; other site 484021008049 NAD(P) binding site [chemical binding]; other site 484021008050 trimer interface B [polypeptide binding]; other site 484021008051 trimer interface A [polypeptide binding]; other site 484021008052 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 484021008053 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 484021008054 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 484021008055 universal stress protein UspE; Provisional; Region: PRK11175 484021008056 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021008057 Ligand Binding Site [chemical binding]; other site 484021008058 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021008059 Ligand Binding Site [chemical binding]; other site 484021008060 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 484021008061 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 484021008062 ligand binding site [chemical binding]; other site 484021008063 flexible hinge region; other site 484021008064 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 484021008065 putative switch regulator; other site 484021008066 non-specific DNA interactions [nucleotide binding]; other site 484021008067 DNA binding site [nucleotide binding] 484021008068 sequence specific DNA binding site [nucleotide binding]; other site 484021008069 putative cAMP binding site [chemical binding]; other site 484021008070 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 484021008071 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 484021008072 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484021008073 DNA binding site [nucleotide binding] 484021008074 active site 484021008075 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 484021008076 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 484021008077 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 484021008078 amidohydrolase; Region: amidohydrolases; TIGR01891 484021008079 putative metal binding site [ion binding]; other site 484021008080 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 484021008081 amidohydrolase; Region: amidohydrolases; TIGR01891 484021008082 putative metal binding site [ion binding]; other site 484021008083 dimer interface [polypeptide binding]; other site 484021008084 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 484021008085 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008086 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 484021008087 putative substrate binding pocket [chemical binding]; other site 484021008088 putative dimerization interface [polypeptide binding]; other site 484021008089 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 484021008090 Smr domain; Region: Smr; pfam01713 484021008091 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 484021008092 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021008093 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021008094 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 484021008095 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 484021008096 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 484021008097 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021008098 dimer interface [polypeptide binding]; other site 484021008099 active site 484021008100 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 484021008101 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 484021008102 tetramer interface [polypeptide binding]; other site 484021008103 active site 484021008104 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 484021008105 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 484021008106 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 484021008107 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484021008108 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021008109 fumarate hydratase; Provisional; Region: PRK15389 484021008110 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 484021008111 Fumarase C-terminus; Region: Fumerase_C; pfam05683 484021008112 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 484021008113 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 484021008114 transmembrane helices; other site 484021008115 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 484021008116 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 484021008117 putative active site [active] 484021008118 putative FMN binding site [chemical binding]; other site 484021008119 putative substrate binding site [chemical binding]; other site 484021008120 putative catalytic residue [active] 484021008121 FMN-binding domain; Region: FMN_bind; cl01081 484021008122 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 484021008123 L-aspartate oxidase; Provisional; Region: PRK06175 484021008124 Predicted oxidoreductase [General function prediction only]; Region: COG3573 484021008125 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 484021008126 ApbE family; Region: ApbE; pfam02424 484021008127 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 484021008128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021008129 active site 484021008130 phosphorylation site [posttranslational modification] 484021008131 intermolecular recognition site; other site 484021008132 dimerization interface [polypeptide binding]; other site 484021008133 sensory histidine kinase DcuS; Provisional; Region: PRK11086 484021008134 PAS domain; Region: PAS; smart00091 484021008135 putative active site [active] 484021008136 heme pocket [chemical binding]; other site 484021008137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021008138 ATP binding site [chemical binding]; other site 484021008139 Mg2+ binding site [ion binding]; other site 484021008140 G-X-G motif; other site 484021008141 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 484021008142 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 484021008143 putative active site [active] 484021008144 malate:quinone oxidoreductase; Validated; Region: PRK05257 484021008145 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 484021008146 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008147 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008148 The C-terminal substrate-binding domian of LysR-type transcriptional regulator MdcR, which involved in the malonate catabolism contains the type 2 periplasmic binding fold; Region: PBP2_MdcR; cd08416 484021008149 putative dimerization interface [polypeptide binding]; other site 484021008150 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484021008151 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 484021008152 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 484021008153 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 484021008154 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 484021008155 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 484021008156 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 484021008157 malonate decarboxylase subunit delta; Provisional; Region: PRK01220 484021008158 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 484021008159 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 484021008160 Coenzyme A transferase; Region: CoA_trans; cl17247 484021008161 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 484021008162 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484021008163 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 484021008164 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 484021008165 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 484021008166 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 484021008167 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 484021008168 active site 484021008169 Zn binding site [ion binding]; other site 484021008170 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021008171 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008172 putative substrate translocation pore; other site 484021008173 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 484021008174 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008175 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 484021008176 dimerization interface [polypeptide binding]; other site 484021008177 substrate binding pocket [chemical binding]; other site 484021008178 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 484021008179 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484021008180 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021008181 nucleotide binding site [chemical binding]; other site 484021008182 putative dithiobiotin synthetase; Provisional; Region: PRK12374 484021008183 AAA domain; Region: AAA_26; pfam13500 484021008184 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 484021008185 Cl- selectivity filter; other site 484021008186 Cl- binding residues [ion binding]; other site 484021008187 pore gating glutamate residue; other site 484021008188 dimer interface [polypeptide binding]; other site 484021008189 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 484021008190 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 484021008191 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 484021008192 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 484021008193 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 484021008194 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 484021008195 putative [Fe4-S4] binding site [ion binding]; other site 484021008196 putative molybdopterin cofactor binding site [chemical binding]; other site 484021008197 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 484021008198 putative molybdopterin cofactor binding site; other site 484021008199 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 484021008200 lipoprotein; Reviewed; Region: PRK02939 484021008201 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 484021008202 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021008203 Coenzyme A binding pocket [chemical binding]; other site 484021008204 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484021008205 hypothetical protein; Provisional; Region: PRK13659 484021008206 hypothetical protein; Provisional; Region: PRK02237 484021008207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008208 D-galactonate transporter; Region: 2A0114; TIGR00893 484021008209 putative substrate translocation pore; other site 484021008210 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 484021008211 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 484021008212 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 484021008213 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021008214 Ligand Binding Site [chemical binding]; other site 484021008215 Transcriptional regulators [Transcription]; Region: GntR; COG1802 484021008216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021008217 DNA-binding site [nucleotide binding]; DNA binding site 484021008218 FCD domain; Region: FCD; pfam07729 484021008219 malonic semialdehyde reductase; Provisional; Region: PRK10538 484021008220 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 484021008221 putative NAD(P) binding site [chemical binding]; other site 484021008222 homodimer interface [polypeptide binding]; other site 484021008223 homotetramer interface [polypeptide binding]; other site 484021008224 active site 484021008225 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 484021008226 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 484021008227 active site 484021008228 Zn binding site [ion binding]; other site 484021008229 SnoaL-like domain; Region: SnoaL_2; pfam12680 484021008230 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021008231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008232 Helix-turn-helix domain; Region: HTH_18; pfam12833 484021008233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008234 hypothetical protein; Provisional; Region: PRK09951 484021008235 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021008236 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021008237 DNA binding residues [nucleotide binding] 484021008238 dimerization interface [polypeptide binding]; other site 484021008239 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 484021008240 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 484021008241 putative dimer interface [polypeptide binding]; other site 484021008242 hypothetical protein; Validated; Region: PRK03657 484021008243 Sensors of blue-light using FAD; Region: BLUF; smart01034 484021008244 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021008245 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021008246 DNA binding residues [nucleotide binding] 484021008247 dimerization interface [polypeptide binding]; other site 484021008248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021008249 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 484021008250 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008251 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 484021008252 putative transporter; Provisional; Region: PRK09821 484021008253 GntP family permease; Region: GntP_permease; pfam02447 484021008254 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 484021008255 putative aldolase; Validated; Region: PRK08130 484021008256 active site 484021008257 intersubunit interface [polypeptide binding]; other site 484021008258 Zn2+ binding site [ion binding]; other site 484021008259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 484021008260 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 484021008261 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 484021008262 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021008263 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021008264 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021008265 beta-lactamase TEM; Provisional; Region: PRK15442 484021008266 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 484021008267 Predicted ATPase [General function prediction only]; Region: COG4637 484021008268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021008269 Walker A/P-loop; other site 484021008270 ATP binding site [chemical binding]; other site 484021008271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021008272 ABC transporter signature motif; other site 484021008273 Walker B; other site 484021008274 D-loop; other site 484021008275 H-loop/switch region; other site 484021008276 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 484021008277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008278 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 484021008279 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 484021008280 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 484021008281 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 484021008282 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 484021008283 lac repressor; Reviewed; Region: lacI; PRK09526 484021008284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021008285 DNA binding site [nucleotide binding] 484021008286 domain linker motif; other site 484021008287 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 484021008288 ligand binding site [chemical binding]; other site 484021008289 dimerization interface (open form) [polypeptide binding]; other site 484021008290 dimerization interface (closed form) [polypeptide binding]; other site 484021008291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021008292 Coenzyme A binding pocket [chemical binding]; other site 484021008293 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 484021008294 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 484021008295 conserved cys residue [active] 484021008296 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008298 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 484021008299 active site residue [active] 484021008300 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 484021008301 substrate binding site [chemical binding]; other site 484021008302 THF binding site; other site 484021008303 zinc-binding site [ion binding]; other site 484021008304 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 484021008305 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 484021008306 putative ligand binding site [chemical binding]; other site 484021008307 HEAT repeats; Region: HEAT_2; pfam13646 484021008308 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 484021008309 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021008310 TM-ABC transporter signature motif; other site 484021008311 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 484021008312 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 484021008313 TM-ABC transporter signature motif; other site 484021008314 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 484021008315 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 484021008316 Walker A/P-loop; other site 484021008317 ATP binding site [chemical binding]; other site 484021008318 Q-loop/lid; other site 484021008319 ABC transporter signature motif; other site 484021008320 Walker B; other site 484021008321 D-loop; other site 484021008322 H-loop/switch region; other site 484021008323 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 484021008324 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 484021008325 Walker A/P-loop; other site 484021008326 ATP binding site [chemical binding]; other site 484021008327 Q-loop/lid; other site 484021008328 ABC transporter signature motif; other site 484021008329 Walker B; other site 484021008330 D-loop; other site 484021008331 H-loop/switch region; other site 484021008332 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021008333 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021008334 non-specific DNA binding site [nucleotide binding]; other site 484021008335 salt bridge; other site 484021008336 sequence-specific DNA binding site [nucleotide binding]; other site 484021008337 2TM domain; Region: 2TM; pfam13239 484021008338 putative transporter; Provisional; Region: PRK10054 484021008339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008340 putative substrate translocation pore; other site 484021008341 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 484021008342 MarB protein; Region: MarB; pfam13999 484021008343 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 484021008344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008346 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 484021008347 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021008348 inner membrane protein; Provisional; Region: PRK10995 484021008349 putative arabinose transporter; Provisional; Region: PRK03545 484021008350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008351 putative substrate translocation pore; other site 484021008352 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 484021008353 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008354 D-galactonate transporter; Region: 2A0114; TIGR00893 484021008355 putative substrate translocation pore; other site 484021008356 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 484021008357 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 484021008358 putative ligand binding site [chemical binding]; other site 484021008359 putative NAD binding site [chemical binding]; other site 484021008360 catalytic site [active] 484021008361 dihydrodipicolinate synthase; Region: dapA; TIGR00674 484021008362 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 484021008363 inhibitor site; inhibition site 484021008364 active site 484021008365 dimer interface [polypeptide binding]; other site 484021008366 catalytic residue [active] 484021008367 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 484021008368 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 484021008369 active site 484021008370 NAD binding site [chemical binding]; other site 484021008371 metal binding site [ion binding]; metal-binding site 484021008372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 484021008373 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 484021008374 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 484021008375 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021008376 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021008377 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021008378 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 484021008379 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021008380 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 484021008381 NAD binding site [chemical binding]; other site 484021008382 dimer interface [polypeptide binding]; other site 484021008383 substrate binding site [chemical binding]; other site 484021008384 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021008385 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 484021008386 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008387 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 484021008388 putative dimerization interface [polypeptide binding]; other site 484021008389 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 484021008390 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 484021008391 NAD(P) binding site [chemical binding]; other site 484021008392 catalytic residues [active] 484021008393 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 484021008394 glutaminase; Provisional; Region: PRK00971 484021008395 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 484021008396 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021008397 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021008398 metal binding site [ion binding]; metal-binding site 484021008399 active site 484021008400 I-site; other site 484021008401 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 484021008402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021008403 Coenzyme A binding pocket [chemical binding]; other site 484021008404 altronate oxidoreductase; Provisional; Region: PRK03643 484021008405 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 484021008406 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 484021008407 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484021008408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021008409 Coenzyme A binding pocket [chemical binding]; other site 484021008410 Protein of unknown function (DUF796); Region: DUF796; cl01226 484021008411 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 484021008412 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 484021008413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021008414 S-adenosylmethionine binding site [chemical binding]; other site 484021008415 major facilitator superfamily transporter; Provisional; Region: PRK05122 484021008416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008417 putative substrate translocation pore; other site 484021008418 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 484021008419 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008421 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021008422 dimerization interface [polypeptide binding]; other site 484021008423 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 484021008424 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 484021008425 FMN binding site [chemical binding]; other site 484021008426 substrate binding site [chemical binding]; other site 484021008427 putative catalytic residue [active] 484021008428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021008429 dimer interface [polypeptide binding]; other site 484021008430 conserved gate region; other site 484021008431 ABC-ATPase subunit interface; other site 484021008432 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021008433 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 484021008434 Walker A/P-loop; other site 484021008435 ATP binding site [chemical binding]; other site 484021008436 Q-loop/lid; other site 484021008437 ABC transporter signature motif; other site 484021008438 Walker B; other site 484021008439 D-loop; other site 484021008440 H-loop/switch region; other site 484021008441 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 484021008442 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 484021008443 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 484021008444 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 484021008445 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 484021008446 Uncharacterized conserved protein (DUF2132); Region: DUF2132; cl01894 484021008447 Cupin domain; Region: Cupin_2; cl17218 484021008448 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 484021008449 Cupin; Region: Cupin_6; pfam12852 484021008450 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021008451 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008453 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 484021008454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008455 putative substrate translocation pore; other site 484021008456 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 484021008457 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 484021008458 FMN-binding pocket [chemical binding]; other site 484021008459 flavin binding motif; other site 484021008460 phosphate binding motif [ion binding]; other site 484021008461 beta-alpha-beta structure motif; other site 484021008462 NAD binding pocket [chemical binding]; other site 484021008463 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021008464 catalytic loop [active] 484021008465 iron binding site [ion binding]; other site 484021008466 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 484021008467 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 484021008468 [2Fe-2S] cluster binding site [ion binding]; other site 484021008469 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 484021008470 hydrophobic ligand binding site; other site 484021008471 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008473 LysR substrate binding domain; Region: LysR_substrate; pfam03466 484021008474 dimerization interface [polypeptide binding]; other site 484021008475 hypothetical protein; Provisional; Region: PRK07236 484021008476 FAD binding domain; Region: FAD_binding_3; pfam01494 484021008477 xanthine permease; Region: pbuX; TIGR03173 484021008478 OHCU decarboxylase; Region: UraD_2; TIGR03180 484021008479 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 484021008480 active site 484021008481 homotetramer interface [polypeptide binding]; other site 484021008482 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021008483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021008484 non-specific DNA binding site [nucleotide binding]; other site 484021008485 salt bridge; other site 484021008486 sequence-specific DNA binding site [nucleotide binding]; other site 484021008487 HipA N-terminal domain; Region: Couple_hipA; pfam13657 484021008488 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 484021008489 HipA-like N-terminal domain; Region: HipA_N; pfam07805 484021008490 HipA-like C-terminal domain; Region: HipA_C; pfam07804 484021008491 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 484021008492 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 484021008493 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021008494 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021008495 PapC N-terminal domain; Region: PapC_N; pfam13954 484021008496 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021008497 PapC C-terminal domain; Region: PapC_C; pfam13953 484021008498 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021008499 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021008500 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021008501 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021008502 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 484021008503 active site 484021008504 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 484021008505 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021008506 PAS domain; Region: PAS_9; pfam13426 484021008507 putative active site [active] 484021008508 heme pocket [chemical binding]; other site 484021008509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021008510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021008511 metal binding site [ion binding]; metal-binding site 484021008512 active site 484021008513 I-site; other site 484021008514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021008515 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 484021008516 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021008517 active site 484021008518 phosphorylation site [posttranslational modification] 484021008519 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484021008520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008521 putative substrate translocation pore; other site 484021008522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008523 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 484021008524 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 484021008525 NAD binding site [chemical binding]; other site 484021008526 sugar binding site [chemical binding]; other site 484021008527 divalent metal binding site [ion binding]; other site 484021008528 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021008529 dimer interface [polypeptide binding]; other site 484021008530 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 484021008531 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021008532 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021008533 active site turn [active] 484021008534 phosphorylation site [posttranslational modification] 484021008535 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 484021008536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021008537 DNA-binding site [nucleotide binding]; DNA binding site 484021008538 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 484021008539 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484021008540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008542 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 484021008543 putative dimerization interface [polypeptide binding]; other site 484021008544 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 484021008545 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 484021008546 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 484021008547 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 484021008548 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 484021008549 glycerate kinase; Region: TIGR00045 484021008550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008551 putative substrate translocation pore; other site 484021008552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021008553 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 484021008554 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 484021008555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008556 putative substrate translocation pore; other site 484021008557 putative acyltransferase; Provisional; Region: PRK05790 484021008558 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021008559 dimer interface [polypeptide binding]; other site 484021008560 active site 484021008561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484021008562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021008563 NAD(P) binding site [chemical binding]; other site 484021008564 active site 484021008565 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 484021008566 Coenzyme A transferase; Region: CoA_trans; smart00882 484021008567 Coenzyme A transferase; Region: CoA_trans; cl17247 484021008568 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 484021008569 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484021008570 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 484021008571 acyl-activating enzyme (AAE) consensus motif; other site 484021008572 acyl-activating enzyme (AAE) consensus motif; other site 484021008573 putative AMP binding site [chemical binding]; other site 484021008574 putative active site [active] 484021008575 putative CoA binding site [chemical binding]; other site 484021008576 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021008577 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 484021008578 active site 484021008579 metal binding site [ion binding]; metal-binding site 484021008580 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 484021008581 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008582 putative substrate translocation pore; other site 484021008583 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 484021008584 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021008585 substrate binding site [chemical binding]; other site 484021008586 dimer interface [polypeptide binding]; other site 484021008587 ATP binding site [chemical binding]; other site 484021008588 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 484021008589 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 484021008590 substrate binding site [chemical binding]; other site 484021008591 hexamer interface [polypeptide binding]; other site 484021008592 metal binding site [ion binding]; metal-binding site 484021008593 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021008594 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021008595 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021008596 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 484021008597 intersubunit interface [polypeptide binding]; other site 484021008598 active site 484021008599 catalytic residue [active] 484021008600 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 484021008601 D-xylulose kinases, subgroup 3; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_3; cd07811 484021008602 putative N- and C-terminal domain interface [polypeptide binding]; other site 484021008603 putative active site [active] 484021008604 putative MgATP binding site [chemical binding]; other site 484021008605 catalytic site [active] 484021008606 metal binding site [ion binding]; metal-binding site 484021008607 putative xylulose binding site [chemical binding]; other site 484021008608 putative homodimer interface [polypeptide binding]; other site 484021008609 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021008610 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021008611 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021008612 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 484021008613 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 484021008614 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 484021008615 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 484021008616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021008617 active site 484021008618 phosphorylation site [posttranslational modification] 484021008619 intermolecular recognition site; other site 484021008620 dimerization interface [polypeptide binding]; other site 484021008621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484021008622 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021008623 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 484021008624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 484021008625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021008626 dimer interface [polypeptide binding]; other site 484021008627 phosphorylation site [posttranslational modification] 484021008628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021008629 ATP binding site [chemical binding]; other site 484021008630 Mg2+ binding site [ion binding]; other site 484021008631 G-X-G motif; other site 484021008632 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 484021008633 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 484021008634 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 484021008635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008637 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 484021008638 BON domain; Region: BON; pfam04972 484021008639 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021008640 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 484021008641 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484021008642 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 484021008643 BtpA family; Region: BtpA; cl00440 484021008644 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021008645 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 484021008646 substrate binding site [chemical binding]; other site 484021008647 ATP binding site [chemical binding]; other site 484021008648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 484021008649 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 484021008650 ligand binding site [chemical binding]; other site 484021008651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021008652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021008653 DNA binding site [nucleotide binding] 484021008654 domain linker motif; other site 484021008655 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 484021008656 putative dimerization interface [polypeptide binding]; other site 484021008657 putative ligand binding site [chemical binding]; other site 484021008658 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021008659 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484021008660 Walker A/P-loop; other site 484021008661 ATP binding site [chemical binding]; other site 484021008662 Q-loop/lid; other site 484021008663 ABC transporter signature motif; other site 484021008664 Walker B; other site 484021008665 D-loop; other site 484021008666 H-loop/switch region; other site 484021008667 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021008668 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021008669 TM-ABC transporter signature motif; other site 484021008670 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 484021008671 active site 484021008672 substrate binding pocket [chemical binding]; other site 484021008673 homodimer interaction site [polypeptide binding]; other site 484021008674 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 484021008675 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 484021008676 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 484021008677 metal binding site [ion binding]; metal-binding site 484021008678 dimer interface [polypeptide binding]; other site 484021008679 TolA C-terminal; Region: TolA; pfam06519 484021008680 TolA protein; Region: tolA_full; TIGR02794 484021008681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484021008682 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008683 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008684 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021008685 putative effector binding pocket; other site 484021008686 dimerization interface [polypeptide binding]; other site 484021008687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008689 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021008690 putative effector binding pocket; other site 484021008691 dimerization interface [polypeptide binding]; other site 484021008692 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021008693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008694 putative substrate translocation pore; other site 484021008695 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 484021008696 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 484021008697 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 484021008698 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 484021008699 active site 484021008700 P-loop; other site 484021008701 phosphorylation site [posttranslational modification] 484021008702 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021008703 active site 484021008704 phosphorylation site [posttranslational modification] 484021008705 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 484021008706 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 484021008707 substrate binding site [chemical binding]; other site 484021008708 hexamer interface [polypeptide binding]; other site 484021008709 metal binding site [ion binding]; metal-binding site 484021008710 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 484021008711 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 484021008712 active site 484021008713 P-loop; other site 484021008714 phosphorylation site [posttranslational modification] 484021008715 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021008716 active site 484021008717 phosphorylation site [posttranslational modification] 484021008718 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021008719 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021008720 DNA binding site [nucleotide binding] 484021008721 domain linker motif; other site 484021008722 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 484021008723 putative dimerization interface [polypeptide binding]; other site 484021008724 putative ligand binding site [chemical binding]; other site 484021008725 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 484021008726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008727 putative substrate translocation pore; other site 484021008728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484021008729 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021008730 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021008731 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021008732 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021008733 EamA-like transporter family; Region: EamA; cl17759 484021008734 EamA-like transporter family; Region: EamA; pfam00892 484021008735 putative sialic acid transporter; Region: 2A0112; TIGR00891 484021008736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008737 putative substrate translocation pore; other site 484021008738 hypothetical protein; Provisional; Region: PRK09897 484021008739 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 484021008740 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 484021008741 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 484021008742 active site 484021008743 FMN binding site [chemical binding]; other site 484021008744 substrate binding site [chemical binding]; other site 484021008745 homotetramer interface [polypeptide binding]; other site 484021008746 catalytic residue [active] 484021008747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008749 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021008750 putative effector binding pocket; other site 484021008751 putative dimerization interface [polypeptide binding]; other site 484021008752 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 484021008753 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 484021008754 FMN binding site [chemical binding]; other site 484021008755 substrate binding site [chemical binding]; other site 484021008756 putative catalytic residue [active] 484021008757 allantoate amidohydrolase; Reviewed; Region: PRK09290 484021008758 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 484021008759 active site 484021008760 metal binding site [ion binding]; metal-binding site 484021008761 dimer interface [polypeptide binding]; other site 484021008762 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 484021008763 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021008764 catalytic residue [active] 484021008765 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021008766 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021008767 Walker A/P-loop; other site 484021008768 ATP binding site [chemical binding]; other site 484021008769 Q-loop/lid; other site 484021008770 ABC transporter signature motif; other site 484021008771 Walker B; other site 484021008772 D-loop; other site 484021008773 H-loop/switch region; other site 484021008774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021008775 dimer interface [polypeptide binding]; other site 484021008776 conserved gate region; other site 484021008777 putative PBP binding loops; other site 484021008778 ABC-ATPase subunit interface; other site 484021008779 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021008780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021008781 dimer interface [polypeptide binding]; other site 484021008782 conserved gate region; other site 484021008783 putative PBP binding loops; other site 484021008784 ABC-ATPase subunit interface; other site 484021008785 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021008786 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021008787 substrate binding pocket [chemical binding]; other site 484021008788 membrane-bound complex binding site; other site 484021008789 hinge residues; other site 484021008790 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021008791 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021008792 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 484021008793 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 484021008794 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 484021008795 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 484021008796 amidase; Provisional; Region: PRK09201 484021008797 Amidase; Region: Amidase; pfam01425 484021008798 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 484021008799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021008800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021008801 Coenzyme A binding pocket [chemical binding]; other site 484021008802 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 484021008803 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484021008804 Predicted transcriptional regulators [Transcription]; Region: COG1733 484021008805 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 484021008806 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 484021008807 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021008808 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021008809 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484021008810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008811 putative substrate translocation pore; other site 484021008812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008813 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 484021008814 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484021008815 dimer interface [polypeptide binding]; other site 484021008816 active site 484021008817 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 484021008818 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021008819 Helix-turn-helix domain; Region: HTH_18; pfam12833 484021008820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008821 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 484021008822 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 484021008823 catalytic triad [active] 484021008824 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 484021008825 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 484021008826 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021008827 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484021008828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008830 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484021008831 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 484021008832 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 484021008833 active site 484021008834 catalytic site [active] 484021008835 tetramer interface [polypeptide binding]; other site 484021008836 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 484021008837 Transcriptional regulators [Transcription]; Region: FadR; COG2186 484021008838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021008839 DNA-binding site [nucleotide binding]; DNA binding site 484021008840 FCD domain; Region: FCD; pfam07729 484021008841 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 484021008842 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 484021008843 Na binding site [ion binding]; other site 484021008844 putative substrate binding site [chemical binding]; other site 484021008845 guanine deaminase; Provisional; Region: PRK09228 484021008846 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 484021008847 active site 484021008848 PAS domain S-box; Region: sensory_box; TIGR00229 484021008849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021008850 putative active site [active] 484021008851 heme pocket [chemical binding]; other site 484021008852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021008853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021008854 metal binding site [ion binding]; metal-binding site 484021008855 active site 484021008856 I-site; other site 484021008857 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 484021008858 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021008859 DNA binding site [nucleotide binding] 484021008860 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484021008861 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 484021008862 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 484021008863 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021008864 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021008865 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021008866 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 484021008867 Putative transcription activator [Transcription]; Region: TenA; COG0819 484021008868 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484021008869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021008870 Walker A/P-loop; other site 484021008871 ATP binding site [chemical binding]; other site 484021008872 Q-loop/lid; other site 484021008873 ABC transporter signature motif; other site 484021008874 Walker B; other site 484021008875 D-loop; other site 484021008876 H-loop/switch region; other site 484021008877 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484021008878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021008879 dimer interface [polypeptide binding]; other site 484021008880 conserved gate region; other site 484021008881 ABC-ATPase subunit interface; other site 484021008882 NMT1/THI5 like; Region: NMT1; pfam09084 484021008883 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 484021008884 substrate binding pocket [chemical binding]; other site 484021008885 membrane-bound complex binding site; other site 484021008886 hinge residues; other site 484021008887 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 484021008888 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021008889 inhibitor-cofactor binding pocket; inhibition site 484021008890 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021008891 catalytic residue [active] 484021008892 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 484021008893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021008894 catalytic residue [active] 484021008895 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008896 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021008898 dimerization interface [polypeptide binding]; other site 484021008899 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 484021008900 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 484021008901 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 484021008902 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484021008903 catalytic residues [active] 484021008904 HAMP domain; Region: HAMP; pfam00672 484021008905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021008906 dimer interface [polypeptide binding]; other site 484021008907 phosphorylation site [posttranslational modification] 484021008908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021008909 ATP binding site [chemical binding]; other site 484021008910 Mg2+ binding site [ion binding]; other site 484021008911 G-X-G motif; other site 484021008912 osmolarity response regulator; Provisional; Region: ompR; PRK09468 484021008913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021008914 active site 484021008915 phosphorylation site [posttranslational modification] 484021008916 intermolecular recognition site; other site 484021008917 dimerization interface [polypeptide binding]; other site 484021008918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021008919 DNA binding site [nucleotide binding] 484021008920 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 484021008921 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 484021008922 active site 484021008923 dimer interface [polypeptide binding]; other site 484021008924 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 484021008925 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 484021008926 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 484021008927 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 484021008928 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 484021008929 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 484021008930 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 484021008931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021008932 FeS/SAM binding site; other site 484021008933 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 484021008934 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 484021008935 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 484021008936 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 484021008937 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 484021008938 catalytic triad [active] 484021008939 penicillin-binding protein 2; Provisional; Region: PRK10795 484021008940 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484021008941 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484021008942 Protein of unknown function, DUF606; Region: DUF606; pfam04657 484021008943 Protein of unknown function, DUF606; Region: DUF606; pfam04657 484021008944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008946 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021008947 putative effector binding pocket; other site 484021008948 dimerization interface [polypeptide binding]; other site 484021008949 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 484021008950 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 484021008951 heme binding site [chemical binding]; other site 484021008952 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 484021008953 heme binding site [chemical binding]; other site 484021008954 Predicted ATPase [General function prediction only]; Region: COG1485 484021008955 magnesium transport protein MgtC; Provisional; Region: PRK15385 484021008956 MgtC family; Region: MgtC; pfam02308 484021008957 benzoate transport; Region: 2A0115; TIGR00895 484021008958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008959 putative substrate translocation pore; other site 484021008960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021008961 putative substrate translocation pore; other site 484021008962 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 484021008963 methionine cluster; other site 484021008964 active site 484021008965 phosphorylation site [posttranslational modification] 484021008966 metal binding site [ion binding]; metal-binding site 484021008967 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484021008968 active site 484021008969 P-loop; other site 484021008970 phosphorylation site [posttranslational modification] 484021008971 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021008972 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021008973 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 484021008974 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484021008975 substrate binding pocket [chemical binding]; other site 484021008976 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484021008977 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 484021008978 Cupin domain; Region: Cupin_2; cl17218 484021008979 Helix-turn-helix domain; Region: HTH_18; pfam12833 484021008980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021008981 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 484021008982 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 484021008983 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484021008984 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021008985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021008986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021008987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021008988 dimerization interface [polypeptide binding]; other site 484021008989 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 484021008990 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 484021008991 putative molybdopterin cofactor binding site [chemical binding]; other site 484021008992 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 484021008993 putative molybdopterin cofactor binding site; other site 484021008994 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 484021008995 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 484021008996 Cation efflux family; Region: Cation_efflux; pfam01545 484021008997 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021008998 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021008999 substrate binding pocket [chemical binding]; other site 484021009000 membrane-bound complex binding site; other site 484021009001 hinge residues; other site 484021009002 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 484021009003 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 484021009004 hypothetical protein; Provisional; Region: PRK10053 484021009005 Predicted membrane protein [Function unknown]; Region: COG2323 484021009006 short chain dehydrogenase; Provisional; Region: PRK07109 484021009007 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 484021009008 putative NAD(P) binding site [chemical binding]; other site 484021009009 active site 484021009010 trehalose synthase; Region: treS_nterm; TIGR02456 484021009011 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 484021009012 active site 484021009013 catalytic site [active] 484021009014 Domain of unknown function (DUF892); Region: DUF892; pfam05974 484021009015 General stress protein [General function prediction only]; Region: GsiB; COG3729 484021009016 oxidoreductase; Provisional; Region: PRK06128 484021009017 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 484021009018 NAD binding site [chemical binding]; other site 484021009019 metal binding site [ion binding]; metal-binding site 484021009020 active site 484021009021 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 484021009022 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021009023 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009024 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021009025 putative effector binding pocket; other site 484021009026 dimerization interface [polypeptide binding]; other site 484021009027 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 484021009028 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 484021009029 malate dehydrogenase; Provisional; Region: PRK13529 484021009030 Malic enzyme, N-terminal domain; Region: malic; pfam00390 484021009031 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 484021009032 NAD(P) binding site [chemical binding]; other site 484021009033 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 484021009034 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021009035 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 484021009036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021009037 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021009038 MarR family; Region: MarR_2; pfam12802 484021009039 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021009040 Coenzyme A binding pocket [chemical binding]; other site 484021009041 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 484021009042 dimer interface [polypeptide binding]; other site 484021009043 substrate binding site [chemical binding]; other site 484021009044 metal binding sites [ion binding]; metal-binding site 484021009045 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 484021009046 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 484021009047 NAD binding site [chemical binding]; other site 484021009048 substrate binding site [chemical binding]; other site 484021009049 catalytic Zn binding site [ion binding]; other site 484021009050 tetramer interface [polypeptide binding]; other site 484021009051 structural Zn binding site [ion binding]; other site 484021009052 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021009053 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 484021009054 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021009055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009056 dimer interface [polypeptide binding]; other site 484021009057 conserved gate region; other site 484021009058 putative PBP binding loops; other site 484021009059 ABC-ATPase subunit interface; other site 484021009060 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484021009061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009062 ABC-ATPase subunit interface; other site 484021009063 putative PBP binding loops; other site 484021009064 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 484021009065 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021009066 Walker A/P-loop; other site 484021009067 ATP binding site [chemical binding]; other site 484021009068 Q-loop/lid; other site 484021009069 ABC transporter signature motif; other site 484021009070 Walker B; other site 484021009071 D-loop; other site 484021009072 H-loop/switch region; other site 484021009073 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021009074 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021009075 Walker A/P-loop; other site 484021009076 ATP binding site [chemical binding]; other site 484021009077 Q-loop/lid; other site 484021009078 ABC transporter signature motif; other site 484021009079 Walker B; other site 484021009080 D-loop; other site 484021009081 H-loop/switch region; other site 484021009082 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021009083 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 484021009084 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 484021009085 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 484021009086 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 484021009087 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 484021009088 MFS transport protein AraJ; Provisional; Region: PRK10091 484021009089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009090 putative substrate translocation pore; other site 484021009091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021009092 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 484021009093 active site 484021009094 metal binding site [ion binding]; metal-binding site 484021009095 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 484021009096 CcdB protein; Region: CcdB; cl03380 484021009097 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 484021009098 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 484021009099 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 484021009100 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 484021009101 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 484021009102 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 484021009103 [4Fe-4S] binding site [ion binding]; other site 484021009104 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021009105 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021009106 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 484021009107 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 484021009108 molybdopterin cofactor binding site; other site 484021009109 aromatic amino acid exporter; Provisional; Region: PRK11689 484021009110 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 484021009111 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 484021009112 putative NAD(P) binding site [chemical binding]; other site 484021009113 active site 484021009114 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 484021009115 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021009116 catalytic loop [active] 484021009117 iron binding site [ion binding]; other site 484021009118 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 484021009119 FAD binding pocket [chemical binding]; other site 484021009120 FAD binding motif [chemical binding]; other site 484021009121 phosphate binding motif [ion binding]; other site 484021009122 beta-alpha-beta structure motif; other site 484021009123 NAD binding pocket [chemical binding]; other site 484021009124 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 484021009125 inter-subunit interface; other site 484021009126 potential frameshift: common BLAST hit: gi|152970424|ref|YP_001335533.1| 3-phenylpropionate dioxygenase, alpha subunit 484021009127 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 484021009128 iron-sulfur cluster [ion binding]; other site 484021009129 [2Fe-2S] cluster binding site [ion binding]; other site 484021009130 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 484021009131 putative alpha subunit interface [polypeptide binding]; other site 484021009132 putative active site [active] 484021009133 putative substrate binding site [chemical binding]; other site 484021009134 Fe binding site [ion binding]; other site 484021009135 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 484021009136 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 484021009137 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 484021009138 dimer interface [polypeptide binding]; other site 484021009139 active site 484021009140 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 484021009141 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 484021009142 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 484021009143 octamer interface [polypeptide binding]; other site 484021009144 active site 484021009145 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 484021009146 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021009147 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021009148 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 484021009149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009150 putative substrate translocation pore; other site 484021009151 TetR family transcriptional regulator; Provisional; Region: PRK14996 484021009152 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021009153 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 484021009154 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 484021009155 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 484021009156 [4Fe-4S] binding site [ion binding]; other site 484021009157 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021009158 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021009159 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021009160 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 484021009161 molybdopterin cofactor binding site; other site 484021009162 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 484021009163 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 484021009164 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 484021009165 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 484021009166 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 484021009167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009168 dimer interface [polypeptide binding]; other site 484021009169 conserved gate region; other site 484021009170 putative PBP binding loops; other site 484021009171 ABC-ATPase subunit interface; other site 484021009172 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 484021009173 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 484021009174 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 484021009175 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484021009176 Walker A/P-loop; other site 484021009177 ATP binding site [chemical binding]; other site 484021009178 Q-loop/lid; other site 484021009179 ABC transporter signature motif; other site 484021009180 Walker B; other site 484021009181 D-loop; other site 484021009182 H-loop/switch region; other site 484021009183 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 484021009184 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 484021009185 active site 1 [active] 484021009186 dimer interface [polypeptide binding]; other site 484021009187 hexamer interface [polypeptide binding]; other site 484021009188 active site 2 [active] 484021009189 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 484021009190 C-terminal domain interface [polypeptide binding]; other site 484021009191 GSH binding site (G-site) [chemical binding]; other site 484021009192 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484021009193 dimer interface [polypeptide binding]; other site 484021009194 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 484021009195 dimer interface [polypeptide binding]; other site 484021009196 N-terminal domain interface [polypeptide binding]; other site 484021009197 substrate binding pocket (H-site) [chemical binding]; other site 484021009198 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021009199 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021009200 substrate binding pocket [chemical binding]; other site 484021009201 membrane-bound complex binding site; other site 484021009202 hinge residues; other site 484021009203 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021009204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021009205 Walker A/P-loop; other site 484021009206 ATP binding site [chemical binding]; other site 484021009207 Q-loop/lid; other site 484021009208 ABC transporter signature motif; other site 484021009209 Walker B; other site 484021009210 D-loop; other site 484021009211 H-loop/switch region; other site 484021009212 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021009213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009214 dimer interface [polypeptide binding]; other site 484021009215 conserved gate region; other site 484021009216 putative PBP binding loops; other site 484021009217 ABC-ATPase subunit interface; other site 484021009218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021009219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021009220 Coenzyme A binding pocket [chemical binding]; other site 484021009221 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021009222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021009223 substrate binding pocket [chemical binding]; other site 484021009224 membrane-bound complex binding site; other site 484021009225 hinge residues; other site 484021009226 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 484021009227 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 484021009228 active site 484021009229 non-prolyl cis peptide bond; other site 484021009230 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484021009231 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 484021009232 metal binding site [ion binding]; metal-binding site 484021009233 dimer interface [polypeptide binding]; other site 484021009234 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 484021009235 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 484021009236 AAA domain; Region: AAA_17; pfam13207 484021009237 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021009238 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009239 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 484021009240 putative effector binding pocket; other site 484021009241 putative dimerization interface [polypeptide binding]; other site 484021009242 L-asparagine permease; Provisional; Region: PRK15049 484021009243 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 484021009244 Uncharacterized conserved protein [Function unknown]; Region: COG3391 484021009245 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 484021009246 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 484021009247 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021009248 N-terminal plug; other site 484021009249 ligand-binding site [chemical binding]; other site 484021009250 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 484021009251 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 484021009252 active site 484021009253 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484021009254 hypothetical protein; Provisional; Region: PRK09981 484021009255 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 484021009256 active site 484021009257 tetramer interface [polypeptide binding]; other site 484021009258 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 484021009259 Prostaglandin dehydrogenases; Region: PGDH; cd05288 484021009260 NAD(P) binding site [chemical binding]; other site 484021009261 substrate binding site [chemical binding]; other site 484021009262 dimer interface [polypeptide binding]; other site 484021009263 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021009264 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021009265 sequence-specific DNA binding site [nucleotide binding]; other site 484021009266 salt bridge; other site 484021009267 Cupin domain; Region: Cupin_2; pfam07883 484021009268 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 484021009269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021009270 Coenzyme A binding pocket [chemical binding]; other site 484021009271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 484021009272 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 484021009273 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021009274 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 484021009275 peptide binding site [polypeptide binding]; other site 484021009276 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484021009277 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 484021009278 NAD(P) binding site [chemical binding]; other site 484021009279 catalytic residues [active] 484021009280 PGAP1-like protein; Region: PGAP1; pfam07819 484021009281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484021009282 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 484021009283 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 484021009284 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 484021009285 tetrameric interface [polypeptide binding]; other site 484021009286 NAD binding site [chemical binding]; other site 484021009287 catalytic residues [active] 484021009288 substrate binding site [chemical binding]; other site 484021009289 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484021009290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 484021009291 putative PBP binding loops; other site 484021009292 dimer interface [polypeptide binding]; other site 484021009293 ABC-ATPase subunit interface; other site 484021009294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009295 dimer interface [polypeptide binding]; other site 484021009296 conserved gate region; other site 484021009297 putative PBP binding loops; other site 484021009298 ABC-ATPase subunit interface; other site 484021009299 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 484021009300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021009301 Walker A/P-loop; other site 484021009302 ATP binding site [chemical binding]; other site 484021009303 Q-loop/lid; other site 484021009304 ABC transporter signature motif; other site 484021009305 Walker B; other site 484021009306 D-loop; other site 484021009307 H-loop/switch region; other site 484021009308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 484021009309 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 484021009310 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021009311 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021009312 DNA-binding site [nucleotide binding]; DNA binding site 484021009313 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021009314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021009315 homodimer interface [polypeptide binding]; other site 484021009316 catalytic residue [active] 484021009317 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 484021009318 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 484021009319 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 484021009320 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 484021009321 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 484021009322 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 484021009323 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 484021009324 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 484021009325 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484021009326 Peptidase family U32; Region: Peptidase_U32; pfam01136 484021009327 Collagenase; Region: DUF3656; pfam12392 484021009328 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021009329 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021009330 non-specific DNA binding site [nucleotide binding]; other site 484021009331 salt bridge; other site 484021009332 sequence-specific DNA binding site [nucleotide binding]; other site 484021009333 Cupin domain; Region: Cupin_2; pfam07883 484021009334 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 484021009335 benzoate transporter; Region: benE; TIGR00843 484021009336 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021009337 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021009338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021009339 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484021009340 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 484021009341 tellurite resistance protein TehB; Provisional; Region: PRK11207 484021009342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021009343 S-adenosylmethionine binding site [chemical binding]; other site 484021009344 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 484021009345 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 484021009346 gating phenylalanine in ion channel; other site 484021009347 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 484021009348 putative trimer interface [polypeptide binding]; other site 484021009349 putative CoA binding site [chemical binding]; other site 484021009350 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 484021009351 putative trimer interface [polypeptide binding]; other site 484021009352 putative CoA binding site [chemical binding]; other site 484021009353 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484021009354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021009355 Coenzyme A binding pocket [chemical binding]; other site 484021009356 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 484021009357 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 484021009358 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 484021009359 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 484021009360 catalytic Zn binding site [ion binding]; other site 484021009361 NAD binding site [chemical binding]; other site 484021009362 structural Zn binding site [ion binding]; other site 484021009363 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 484021009364 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 484021009365 substrate binding pocket [chemical binding]; other site 484021009366 catalytic triad [active] 484021009367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 484021009368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 484021009369 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 484021009370 heterodimer interface [polypeptide binding]; other site 484021009371 multimer interface [polypeptide binding]; other site 484021009372 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 484021009373 active site 484021009374 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 484021009375 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 484021009376 heterodimer interface [polypeptide binding]; other site 484021009377 active site 484021009378 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 484021009379 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009380 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 484021009381 putative dimerization interface [polypeptide binding]; other site 484021009382 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 484021009383 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 484021009384 Trp docking motif [polypeptide binding]; other site 484021009385 putative active site [active] 484021009386 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 484021009387 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 484021009388 substrate binding site [chemical binding]; other site 484021009389 catalytic Zn binding site [ion binding]; other site 484021009390 NAD binding site [chemical binding]; other site 484021009391 structural Zn binding site [ion binding]; other site 484021009392 dimer interface [polypeptide binding]; other site 484021009393 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 484021009394 putative metal binding site [ion binding]; other site 484021009395 putative homodimer interface [polypeptide binding]; other site 484021009396 putative homotetramer interface [polypeptide binding]; other site 484021009397 putative homodimer-homodimer interface [polypeptide binding]; other site 484021009398 putative allosteric switch controlling residues; other site 484021009399 cytochrome b561; Provisional; Region: PRK11513 484021009400 Predicted transcriptional regulators [Transcription]; Region: COG1733 484021009401 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 484021009402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009403 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021009404 putative substrate translocation pore; other site 484021009405 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 484021009406 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 484021009407 active site 484021009408 purine riboside binding site [chemical binding]; other site 484021009409 putative oxidoreductase; Provisional; Region: PRK11579 484021009410 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021009411 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021009412 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 484021009413 beta-galactosidase; Region: BGL; TIGR03356 484021009414 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 484021009415 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021009416 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021009417 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 484021009418 electron transport complex protein RsxA; Provisional; Region: PRK05151 484021009419 electron transport complex protein RnfB; Provisional; Region: PRK05113 484021009420 Putative Fe-S cluster; Region: FeS; cl17515 484021009421 4Fe-4S binding domain; Region: Fer4; cl02805 484021009422 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 484021009423 SLBB domain; Region: SLBB; pfam10531 484021009424 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 484021009425 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 484021009426 electron transport complex protein RnfG; Validated; Region: PRK01908 484021009427 electron transport complex RsxE subunit; Provisional; Region: PRK12405 484021009428 endonuclease III; Provisional; Region: PRK10702 484021009429 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484021009430 minor groove reading motif; other site 484021009431 helix-hairpin-helix signature motif; other site 484021009432 substrate binding pocket [chemical binding]; other site 484021009433 active site 484021009434 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 484021009435 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 484021009436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009437 putative substrate translocation pore; other site 484021009438 POT family; Region: PTR2; pfam00854 484021009439 glutathionine S-transferase; Provisional; Region: PRK10542 484021009440 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 484021009441 C-terminal domain interface [polypeptide binding]; other site 484021009442 GSH binding site (G-site) [chemical binding]; other site 484021009443 dimer interface [polypeptide binding]; other site 484021009444 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 484021009445 N-terminal domain interface [polypeptide binding]; other site 484021009446 dimer interface [polypeptide binding]; other site 484021009447 substrate binding pocket (H-site) [chemical binding]; other site 484021009448 pyridoxamine kinase; Validated; Region: PRK05756 484021009449 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 484021009450 dimer interface [polypeptide binding]; other site 484021009451 pyridoxal binding site [chemical binding]; other site 484021009452 ATP binding site [chemical binding]; other site 484021009453 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 484021009454 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 484021009455 active site 484021009456 HIGH motif; other site 484021009457 dimer interface [polypeptide binding]; other site 484021009458 KMSKS motif; other site 484021009459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021009460 RNA binding surface [nucleotide binding]; other site 484021009461 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 484021009462 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 484021009463 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 484021009464 lysozyme inhibitor; Provisional; Region: PRK11372 484021009465 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 484021009466 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 484021009467 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 484021009468 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021009469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021009470 metal binding site [ion binding]; metal-binding site 484021009471 active site 484021009472 I-site; other site 484021009473 transcriptional regulator SlyA; Provisional; Region: PRK03573 484021009474 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 484021009475 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 484021009476 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 484021009477 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021009478 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021009479 Fusaric acid resistance protein family; Region: FUSC; pfam04632 484021009480 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484021009481 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 484021009482 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 484021009483 E-class dimer interface [polypeptide binding]; other site 484021009484 P-class dimer interface [polypeptide binding]; other site 484021009485 active site 484021009486 Cu2+ binding site [ion binding]; other site 484021009487 Zn2+ binding site [ion binding]; other site 484021009488 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021009489 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021009490 active site 484021009491 catalytic tetrad [active] 484021009492 Predicted Fe-S protein [General function prediction only]; Region: COG3313 484021009493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021009494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021009495 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 484021009496 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 484021009497 FMN binding site [chemical binding]; other site 484021009498 active site 484021009499 substrate binding site [chemical binding]; other site 484021009500 catalytic residue [active] 484021009501 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021009502 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 484021009503 dimer interface [polypeptide binding]; other site 484021009504 active site 484021009505 metal binding site [ion binding]; metal-binding site 484021009506 glutathione binding site [chemical binding]; other site 484021009507 ribonuclease T; Provisional; Region: PRK05168 484021009508 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 484021009509 active site 484021009510 catalytic site [active] 484021009511 substrate binding site [chemical binding]; other site 484021009512 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 484021009513 putative GSH binding site [chemical binding]; other site 484021009514 catalytic residues [active] 484021009515 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 484021009516 NlpC/P60 family; Region: NLPC_P60; pfam00877 484021009517 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 484021009518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021009519 superoxide dismutase; Provisional; Region: PRK10543 484021009520 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 484021009521 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 484021009522 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484021009523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009524 putative substrate translocation pore; other site 484021009525 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 484021009526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021009527 DNA binding site [nucleotide binding] 484021009528 domain linker motif; other site 484021009529 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 484021009530 dimerization interface [polypeptide binding]; other site 484021009531 ligand binding site [chemical binding]; other site 484021009532 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 484021009533 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021009535 dimerization interface [polypeptide binding]; other site 484021009536 putative transporter; Provisional; Region: PRK11043 484021009537 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009538 putative substrate translocation pore; other site 484021009539 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 484021009540 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021009541 S-adenosylmethionine binding site [chemical binding]; other site 484021009542 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 484021009543 Lumazine binding domain; Region: Lum_binding; pfam00677 484021009544 Lumazine binding domain; Region: Lum_binding; pfam00677 484021009545 multidrug efflux protein; Reviewed; Region: PRK01766 484021009546 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 484021009547 cation binding site [ion binding]; other site 484021009548 potential protein location (hypothetical protein) that overlaps protein (acid shock protein) 484021009549 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 484021009550 short chain dehydrogenase; Provisional; Region: PRK06180 484021009551 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 484021009552 NADP binding site [chemical binding]; other site 484021009553 active site 484021009554 steroid binding site; other site 484021009555 Cupin; Region: Cupin_6; pfam12852 484021009556 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484021009557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021009558 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 484021009559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009560 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021009561 dimerization interface [polypeptide binding]; other site 484021009562 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484021009563 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 484021009564 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 484021009565 active site clefts [active] 484021009566 zinc binding site [ion binding]; other site 484021009567 dimer interface [polypeptide binding]; other site 484021009568 LysE type translocator; Region: LysE; cl00565 484021009569 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021009570 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021009571 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021009572 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 484021009573 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021009574 putative metal binding site [ion binding]; other site 484021009575 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 484021009576 Chloramphenicol acetyltransferase; Region: CAT; cl02008 484021009577 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021009578 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 484021009579 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021009580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009581 dimer interface [polypeptide binding]; other site 484021009582 conserved gate region; other site 484021009583 putative PBP binding loops; other site 484021009584 ABC-ATPase subunit interface; other site 484021009585 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484021009586 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021009587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009588 dimer interface [polypeptide binding]; other site 484021009589 conserved gate region; other site 484021009590 putative PBP binding loops; other site 484021009591 ABC-ATPase subunit interface; other site 484021009592 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 484021009593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021009594 Walker A/P-loop; other site 484021009595 ATP binding site [chemical binding]; other site 484021009596 Q-loop/lid; other site 484021009597 ABC transporter signature motif; other site 484021009598 Walker B; other site 484021009599 D-loop; other site 484021009600 H-loop/switch region; other site 484021009601 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021009602 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 484021009603 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021009604 Walker A/P-loop; other site 484021009605 ATP binding site [chemical binding]; other site 484021009606 Q-loop/lid; other site 484021009607 ABC transporter signature motif; other site 484021009608 Walker B; other site 484021009609 D-loop; other site 484021009610 H-loop/switch region; other site 484021009611 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 484021009612 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 484021009613 DinB family; Region: DinB; cl17821 484021009614 DinB superfamily; Region: DinB_2; pfam12867 484021009615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009616 putative substrate translocation pore; other site 484021009617 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484021009618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021009619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009620 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 484021009621 putative effector binding pocket; other site 484021009622 putative dimerization interface [polypeptide binding]; other site 484021009623 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 484021009624 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 484021009625 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 484021009626 amidohydrolase; Provisional; Region: PRK12393 484021009627 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 484021009628 active site 484021009629 putative substrate binding pocket [chemical binding]; other site 484021009630 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 484021009631 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009632 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021009633 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021009634 dimerization interface [polypeptide binding]; other site 484021009635 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 484021009636 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 484021009637 FMN-binding pocket [chemical binding]; other site 484021009638 flavin binding motif; other site 484021009639 phosphate binding motif [ion binding]; other site 484021009640 beta-alpha-beta structure motif; other site 484021009641 NAD binding pocket [chemical binding]; other site 484021009642 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021009643 catalytic loop [active] 484021009644 iron binding site [ion binding]; other site 484021009645 cytosine deaminase-like protein; Validated; Region: PRK07583 484021009646 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 484021009647 active site 484021009648 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484021009649 homotrimer interaction site [polypeptide binding]; other site 484021009650 putative active site [active] 484021009651 Creatinine amidohydrolase; Region: Creatininase; pfam02633 484021009652 potential frameshift: common BLAST hit: gi|152970588|ref|YP_001335697.1| ABC transporter periplasmic-binding protein 484021009653 NMT1/THI5 like; Region: NMT1; pfam09084 484021009654 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484021009655 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484021009656 Walker A/P-loop; other site 484021009657 ATP binding site [chemical binding]; other site 484021009658 Q-loop/lid; other site 484021009659 ABC transporter signature motif; other site 484021009660 Walker B; other site 484021009661 D-loop; other site 484021009662 H-loop/switch region; other site 484021009663 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484021009664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009665 dimer interface [polypeptide binding]; other site 484021009666 conserved gate region; other site 484021009667 putative PBP binding loops; other site 484021009668 ABC-ATPase subunit interface; other site 484021009669 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484021009670 FAD binding domain; Region: FAD_binding_4; pfam01565 484021009671 potential frameshift: common BLAST hit: gi|152970595|ref|YP_001335704.1| putative chromate transporter 484021009672 Chromate transporter; Region: Chromate_transp; pfam02417 484021009673 Protein of unknown function (DUF535); Region: DUF535; cl01128 484021009674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021009675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009676 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 484021009677 putative dimerization interface [polypeptide binding]; other site 484021009678 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 484021009679 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 484021009680 putative acyltransferase; Provisional; Region: PRK05790 484021009681 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021009682 dimer interface [polypeptide binding]; other site 484021009683 active site 484021009684 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 484021009685 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 484021009686 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021009687 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 484021009688 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 484021009689 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 484021009690 NAD binding site [chemical binding]; other site 484021009691 homotetramer interface [polypeptide binding]; other site 484021009692 homodimer interface [polypeptide binding]; other site 484021009693 substrate binding site [chemical binding]; other site 484021009694 active site 484021009695 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 484021009696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009697 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 484021009698 putative dimerization interface [polypeptide binding]; other site 484021009699 putative substrate binding pocket [chemical binding]; other site 484021009700 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 484021009701 acetolactate synthase; Reviewed; Region: PRK08617 484021009702 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021009703 PYR/PP interface [polypeptide binding]; other site 484021009704 dimer interface [polypeptide binding]; other site 484021009705 TPP binding site [chemical binding]; other site 484021009706 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021009707 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 484021009708 TPP-binding site [chemical binding]; other site 484021009709 dimer interface [polypeptide binding]; other site 484021009710 acetoin reductase; Validated; Region: PRK08643 484021009711 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 484021009712 NAD binding site [chemical binding]; other site 484021009713 homotetramer interface [polypeptide binding]; other site 484021009714 homodimer interface [polypeptide binding]; other site 484021009715 active site 484021009716 substrate binding site [chemical binding]; other site 484021009717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 484021009718 Integrase core domain; Region: rve; pfam00665 484021009719 Integrase core domain; Region: rve_3; pfam13683 484021009720 Transposase; Region: HTH_Tnp_1; pfam01527 484021009721 SIR2-like domain; Region: SIR2_2; pfam13289 484021009722 AAA domain; Region: AAA_31; pfam13614 484021009723 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021009724 P-loop; other site 484021009725 Magnesium ion binding site [ion binding]; other site 484021009726 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021009727 Magnesium ion binding site [ion binding]; other site 484021009728 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 484021009729 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 484021009730 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 484021009731 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 484021009732 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484021009733 catalytic residues [active] 484021009734 central insert; other site 484021009735 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 484021009736 CcmE; Region: CcmE; cl00994 484021009737 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 484021009738 heme exporter protein CcmC; Region: ccmC; TIGR01191 484021009739 heme exporter protein CcmB; Region: ccmB; TIGR01190 484021009740 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 484021009741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021009742 Walker A/P-loop; other site 484021009743 ATP binding site [chemical binding]; other site 484021009744 Q-loop/lid; other site 484021009745 ABC transporter signature motif; other site 484021009746 Walker B; other site 484021009747 D-loop; other site 484021009748 H-loop/switch region; other site 484021009749 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 484021009750 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 484021009751 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 484021009752 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 484021009753 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 484021009754 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 484021009755 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 484021009756 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 484021009757 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021009758 hypothetical protein; Region: PHA02053 484021009759 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cl08187 484021009760 CRISPR-associated endonuclease Cas1, subtype I-E/ECOLI; Region: cas1_ECOLI; TIGR03638 484021009761 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 484021009762 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 484021009763 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 484021009764 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 484021009765 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 484021009766 CRISPR-associated protein Cse1 (CRISPR_cse1); Region: CRISPR_Cse1; pfam09481 484021009767 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 484021009768 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 484021009769 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 484021009770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021009771 Walker A/P-loop; other site 484021009772 ATP binding site [chemical binding]; other site 484021009773 Q-loop/lid; other site 484021009774 ABC transporter signature motif; other site 484021009775 Walker B; other site 484021009776 D-loop; other site 484021009777 H-loop/switch region; other site 484021009778 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 484021009779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009780 dimer interface [polypeptide binding]; other site 484021009781 conserved gate region; other site 484021009782 ABC-ATPase subunit interface; other site 484021009783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009784 dimer interface [polypeptide binding]; other site 484021009785 conserved gate region; other site 484021009786 putative PBP binding loops; other site 484021009787 ABC-ATPase subunit interface; other site 484021009788 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 484021009789 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 484021009790 putative dehydrogenase; Provisional; Region: PRK10098 484021009791 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 484021009792 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 484021009793 [4Fe-4S] binding site [ion binding]; other site 484021009794 molybdopterin cofactor binding site; other site 484021009795 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 484021009796 molybdopterin cofactor binding site; other site 484021009797 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484021009798 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 484021009799 metal binding site [ion binding]; metal-binding site 484021009800 putative dimer interface [polypeptide binding]; other site 484021009801 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 484021009802 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021009803 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 484021009804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009805 putative substrate translocation pore; other site 484021009806 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 484021009807 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484021009808 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 484021009809 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021009810 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021009811 Walker A/P-loop; other site 484021009812 ATP binding site [chemical binding]; other site 484021009813 Q-loop/lid; other site 484021009814 ABC transporter signature motif; other site 484021009815 Walker B; other site 484021009816 D-loop; other site 484021009817 H-loop/switch region; other site 484021009818 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021009819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009820 dimer interface [polypeptide binding]; other site 484021009821 conserved gate region; other site 484021009822 putative PBP binding loops; other site 484021009823 ABC-ATPase subunit interface; other site 484021009824 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021009825 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021009826 substrate binding pocket [chemical binding]; other site 484021009827 membrane-bound complex binding site; other site 484021009828 hinge residues; other site 484021009829 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021009830 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021009831 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 484021009832 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 484021009833 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 484021009834 siderophore binding site; other site 484021009835 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021009836 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021009837 ABC-ATPase subunit interface; other site 484021009838 dimer interface [polypeptide binding]; other site 484021009839 putative PBP binding regions; other site 484021009840 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021009841 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021009842 ABC-ATPase subunit interface; other site 484021009843 dimer interface [polypeptide binding]; other site 484021009844 putative PBP binding regions; other site 484021009845 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 484021009846 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021009847 Walker A/P-loop; other site 484021009848 ATP binding site [chemical binding]; other site 484021009849 Q-loop/lid; other site 484021009850 ABC transporter signature motif; other site 484021009851 Walker B; other site 484021009852 D-loop; other site 484021009853 H-loop/switch region; other site 484021009854 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 484021009855 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021009856 N-terminal plug; other site 484021009857 ligand-binding site [chemical binding]; other site 484021009858 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484021009859 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484021009860 Walker A/P-loop; other site 484021009861 ATP binding site [chemical binding]; other site 484021009862 Q-loop/lid; other site 484021009863 ABC transporter signature motif; other site 484021009864 Walker B; other site 484021009865 D-loop; other site 484021009866 H-loop/switch region; other site 484021009867 potential frameshift: common BLAST hit: gi|152970656|ref|YP_001335765.1| ABC-type transport system, permease component 484021009868 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484021009869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021009870 dimer interface [polypeptide binding]; other site 484021009871 conserved gate region; other site 484021009872 putative PBP binding loops; other site 484021009873 ABC-ATPase subunit interface; other site 484021009874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 484021009875 NMT1/THI5 like; Region: NMT1; pfam09084 484021009876 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021009877 membrane-bound complex binding site; other site 484021009878 hinge residues; other site 484021009879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 484021009880 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 484021009881 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 484021009882 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 484021009883 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 484021009884 dimer interface [polypeptide binding]; other site 484021009885 active site 484021009886 non-prolyl cis peptide bond; other site 484021009887 insertion regions; other site 484021009888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021009889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021009890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021009891 dimerization interface [polypeptide binding]; other site 484021009892 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 484021009893 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 484021009894 active site residue [active] 484021009895 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 484021009896 active site residue [active] 484021009897 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 484021009898 active site residue [active] 484021009899 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 484021009900 active site residue [active] 484021009901 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 484021009902 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 484021009903 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 484021009904 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 484021009905 active site 484021009906 catalytic residues [active] 484021009907 metal binding site [ion binding]; metal-binding site 484021009908 DmpG-like communication domain; Region: DmpG_comm; pfam07836 484021009909 acetaldehyde dehydrogenase; Validated; Region: PRK08300 484021009910 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484021009911 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 484021009912 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 484021009913 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 484021009914 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 484021009915 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 484021009916 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 484021009917 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 484021009918 putative active site [active] 484021009919 Fe(II) binding site [ion binding]; other site 484021009920 putative dimer interface [polypeptide binding]; other site 484021009921 putative tetramer interface [polypeptide binding]; other site 484021009922 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 484021009923 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484021009924 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 484021009925 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021009926 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021009927 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 484021009928 putative ligand binding residues [chemical binding]; other site 484021009929 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 484021009930 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 484021009931 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021009932 ABC-ATPase subunit interface; other site 484021009933 dimer interface [polypeptide binding]; other site 484021009934 putative PBP binding regions; other site 484021009935 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 484021009936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021009937 Walker A/P-loop; other site 484021009938 ATP binding site [chemical binding]; other site 484021009939 Q-loop/lid; other site 484021009940 ABC transporter signature motif; other site 484021009941 Walker B; other site 484021009942 D-loop; other site 484021009943 H-loop/switch region; other site 484021009944 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 484021009945 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 484021009946 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 484021009947 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484021009948 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484021009949 shikimate binding site; other site 484021009950 NAD(P) binding site [chemical binding]; other site 484021009951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021009952 D-galactonate transporter; Region: 2A0114; TIGR00893 484021009953 putative substrate translocation pore; other site 484021009954 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 484021009955 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 484021009956 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 484021009957 active site 484021009958 Fe binding site [ion binding]; other site 484021009959 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 484021009960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021009961 Protein of unknown function (DUF2767); Region: DUF2767; pfam10965 484021009962 pyruvate kinase; Provisional; Region: PRK09206 484021009963 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 484021009964 domain interfaces; other site 484021009965 active site 484021009966 murein lipoprotein; Provisional; Region: PRK15396 484021009967 L,D-transpeptidase; Provisional; Region: PRK10260 484021009968 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021009969 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484021009970 cysteine desufuration protein SufE; Provisional; Region: PRK09296 484021009971 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 484021009972 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 484021009973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021009974 catalytic residue [active] 484021009975 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 484021009976 FeS assembly protein SufD; Region: sufD; TIGR01981 484021009977 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 484021009978 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 484021009979 Walker A/P-loop; other site 484021009980 ATP binding site [chemical binding]; other site 484021009981 Q-loop/lid; other site 484021009982 ABC transporter signature motif; other site 484021009983 Walker B; other site 484021009984 D-loop; other site 484021009985 H-loop/switch region; other site 484021009986 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 484021009987 putative ABC transporter; Region: ycf24; CHL00085 484021009988 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 484021009989 DoxX; Region: DoxX; pfam07681 484021009990 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021009991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021009992 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 484021009993 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 484021009994 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484021009995 phosphate binding site [ion binding]; other site 484021009996 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 484021009997 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484021009998 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021009999 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021010000 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021010001 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484021010002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021010003 NAD(P) binding site [chemical binding]; other site 484021010004 active site 484021010005 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021010006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010007 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021010008 dimerization interface [polypeptide binding]; other site 484021010009 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 484021010010 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 484021010011 intersubunit interface [polypeptide binding]; other site 484021010012 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021010013 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021010014 ABC-ATPase subunit interface; other site 484021010015 dimer interface [polypeptide binding]; other site 484021010016 putative PBP binding regions; other site 484021010017 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 484021010018 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021010019 Walker A/P-loop; other site 484021010020 ATP binding site [chemical binding]; other site 484021010021 Q-loop/lid; other site 484021010022 ABC transporter signature motif; other site 484021010023 Walker B; other site 484021010024 D-loop; other site 484021010025 H-loop/switch region; other site 484021010026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021010027 methionine synthase; Provisional; Region: PRK01207 484021010028 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 484021010029 substrate binding site [chemical binding]; other site 484021010030 THF binding site; other site 484021010031 zinc-binding site [ion binding]; other site 484021010032 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 484021010033 hypothetical protein; Provisional; Region: PRK10457 484021010034 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 484021010035 CoenzymeA binding site [chemical binding]; other site 484021010036 subunit interaction site [polypeptide binding]; other site 484021010037 PHB binding site; other site 484021010038 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 484021010039 FAD binding domain; Region: FAD_binding_4; pfam01565 484021010040 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 484021010041 putative inner membrane protein; Provisional; Region: PRK10983 484021010042 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484021010043 phosphoenolpyruvate synthase; Validated; Region: PRK06464 484021010044 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 484021010045 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484021010046 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 484021010047 PEP synthetase regulatory protein; Provisional; Region: PRK05339 484021010048 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 484021010049 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484021010050 hypothetical protein; Provisional; Region: PRK10183 484021010051 Uncharacterized conserved protein [Function unknown]; Region: COG0397 484021010052 hypothetical protein; Validated; Region: PRK00029 484021010053 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 484021010054 NlpC/P60 family; Region: NLPC_P60; pfam00877 484021010055 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 484021010056 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021010057 Walker A/P-loop; other site 484021010058 ATP binding site [chemical binding]; other site 484021010059 Q-loop/lid; other site 484021010060 ABC transporter signature motif; other site 484021010061 Walker B; other site 484021010062 D-loop; other site 484021010063 H-loop/switch region; other site 484021010064 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 484021010065 catalytic residues [active] 484021010066 dimer interface [polypeptide binding]; other site 484021010067 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 484021010068 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 484021010069 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021010070 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021010071 ABC-ATPase subunit interface; other site 484021010072 dimer interface [polypeptide binding]; other site 484021010073 putative PBP binding regions; other site 484021010074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021010075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021010077 dimerization interface [polypeptide binding]; other site 484021010078 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 484021010079 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021010080 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 484021010081 homotrimer interaction site [polypeptide binding]; other site 484021010082 putative active site [active] 484021010083 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 484021010084 IHF dimer interface [polypeptide binding]; other site 484021010085 IHF - DNA interface [nucleotide binding]; other site 484021010086 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 484021010087 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 484021010088 putative tRNA-binding site [nucleotide binding]; other site 484021010089 B3/4 domain; Region: B3_4; pfam03483 484021010090 tRNA synthetase B5 domain; Region: B5; smart00874 484021010091 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 484021010092 dimer interface [polypeptide binding]; other site 484021010093 motif 1; other site 484021010094 motif 3; other site 484021010095 motif 2; other site 484021010096 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 484021010097 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 484021010098 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 484021010099 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 484021010100 dimer interface [polypeptide binding]; other site 484021010101 motif 1; other site 484021010102 active site 484021010103 motif 2; other site 484021010104 motif 3; other site 484021010105 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 484021010106 23S rRNA binding site [nucleotide binding]; other site 484021010107 L21 binding site [polypeptide binding]; other site 484021010108 L13 binding site [polypeptide binding]; other site 484021010109 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 484021010110 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 484021010111 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 484021010112 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 484021010113 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 484021010114 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 484021010115 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 484021010116 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 484021010117 active site 484021010118 dimer interface [polypeptide binding]; other site 484021010119 motif 1; other site 484021010120 motif 2; other site 484021010121 motif 3; other site 484021010122 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 484021010123 anticodon binding site; other site 484021010124 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 484021010125 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 484021010126 6-phosphofructokinase 2; Provisional; Region: PRK10294 484021010127 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 484021010128 putative substrate binding site [chemical binding]; other site 484021010129 putative ATP binding site [chemical binding]; other site 484021010130 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 484021010131 Phosphotransferase enzyme family; Region: APH; pfam01636 484021010132 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 484021010133 active site 484021010134 ATP binding site [chemical binding]; other site 484021010135 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 484021010136 active site 484021010137 ATP binding site [chemical binding]; other site 484021010138 transport protein TonB; Provisional; Region: PRK10819 484021010139 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 484021010140 YciI-like protein; Reviewed; Region: PRK11370 484021010141 Uncharacterized conserved protein [Function unknown]; Region: COG2353 484021010142 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 484021010143 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 484021010144 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 484021010145 putative active site [active] 484021010146 catalytic site [active] 484021010147 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 484021010148 putative active site [active] 484021010149 catalytic site [active] 484021010150 dsDNA-mimic protein; Reviewed; Region: PRK05094 484021010151 Ion transport protein; Region: Ion_trans; pfam00520 484021010152 Ion channel; Region: Ion_trans_2; pfam07885 484021010153 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 484021010154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021010155 Walker A/P-loop; other site 484021010156 ATP binding site [chemical binding]; other site 484021010157 Q-loop/lid; other site 484021010158 ABC transporter signature motif; other site 484021010159 Walker B; other site 484021010160 D-loop; other site 484021010161 H-loop/switch region; other site 484021010162 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 484021010163 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 484021010164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021010165 Walker A/P-loop; other site 484021010166 ATP binding site [chemical binding]; other site 484021010167 Q-loop/lid; other site 484021010168 ABC transporter signature motif; other site 484021010169 Walker B; other site 484021010170 D-loop; other site 484021010171 H-loop/switch region; other site 484021010172 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 484021010173 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 484021010174 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021010175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021010176 dimer interface [polypeptide binding]; other site 484021010177 conserved gate region; other site 484021010178 ABC-ATPase subunit interface; other site 484021010179 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 484021010180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021010181 dimer interface [polypeptide binding]; other site 484021010182 conserved gate region; other site 484021010183 putative PBP binding loops; other site 484021010184 ABC-ATPase subunit interface; other site 484021010185 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 484021010186 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 484021010187 peptide binding site [polypeptide binding]; other site 484021010188 hypothetical protein; Provisional; Region: PRK11111 484021010189 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 484021010190 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 484021010191 putative catalytic cysteine [active] 484021010192 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 484021010193 putative active site [active] 484021010194 metal binding site [ion binding]; metal-binding site 484021010195 thymidine kinase; Provisional; Region: PRK04296 484021010196 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 484021010197 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 484021010198 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 484021010199 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 484021010200 active site 484021010201 tetramer interface; other site 484021010202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021010203 active site 484021010204 response regulator of RpoS; Provisional; Region: PRK10693 484021010205 phosphorylation site [posttranslational modification] 484021010206 intermolecular recognition site; other site 484021010207 dimerization interface [polypeptide binding]; other site 484021010208 hypothetical protein; Provisional; Region: PRK10279 484021010209 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 484021010210 nucleophile elbow; other site 484021010211 SEC-C motif; Region: SEC-C; pfam02810 484021010212 hypothetical protein; Provisional; Region: PRK04233 484021010213 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 484021010214 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 484021010215 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 484021010216 putative active site [active] 484021010217 putative substrate binding site [chemical binding]; other site 484021010218 putative cosubstrate binding site; other site 484021010219 catalytic site [active] 484021010220 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 484021010221 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 484021010222 AsnC family; Region: AsnC_trans_reg; pfam01037 484021010223 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021010224 EamA-like transporter family; Region: EamA; pfam00892 484021010225 EamA-like transporter family; Region: EamA; pfam00892 484021010226 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 484021010227 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 484021010228 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 484021010229 4Fe-4S binding domain; Region: Fer4; cl02805 484021010230 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 484021010231 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 484021010232 [4Fe-4S] binding site [ion binding]; other site 484021010233 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021010234 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021010235 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484021010236 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 484021010237 molybdopterin cofactor binding site; other site 484021010238 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 484021010239 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 484021010240 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 484021010241 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021010242 dimerization interface [polypeptide binding]; other site 484021010243 Histidine kinase; Region: HisKA_3; pfam07730 484021010244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021010245 ATP binding site [chemical binding]; other site 484021010246 Mg2+ binding site [ion binding]; other site 484021010247 G-X-G motif; other site 484021010248 transcriptional regulator NarL; Provisional; Region: PRK10651 484021010249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021010250 active site 484021010251 phosphorylation site [posttranslational modification] 484021010252 intermolecular recognition site; other site 484021010253 dimerization interface [polypeptide binding]; other site 484021010254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021010255 DNA binding residues [nucleotide binding] 484021010256 dimerization interface [polypeptide binding]; other site 484021010257 putative invasin; Provisional; Region: PRK10177 484021010258 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 484021010259 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 484021010260 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 484021010261 [4Fe-4S] binding site [ion binding]; other site 484021010262 molybdopterin cofactor binding site; other site 484021010263 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 484021010264 molybdopterin cofactor binding site; other site 484021010265 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 484021010266 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 484021010267 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021010268 nitrite reductase subunit NirD; Provisional; Region: PRK14989 484021010269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021010270 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 484021010271 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 484021010272 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 484021010273 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484021010274 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484021010275 Walker A/P-loop; other site 484021010276 ATP binding site [chemical binding]; other site 484021010277 Q-loop/lid; other site 484021010278 ABC transporter signature motif; other site 484021010279 Walker B; other site 484021010280 D-loop; other site 484021010281 H-loop/switch region; other site 484021010282 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484021010283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021010284 dimer interface [polypeptide binding]; other site 484021010285 conserved gate region; other site 484021010286 putative PBP binding loops; other site 484021010287 ABC-ATPase subunit interface; other site 484021010288 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 484021010289 NMT1-like family; Region: NMT1_2; pfam13379 484021010290 Nitrate and nitrite sensing; Region: NIT; pfam08376 484021010291 ANTAR domain; Region: ANTAR; pfam03861 484021010292 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 484021010293 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 484021010294 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 484021010295 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 484021010296 putative active site pocket [active] 484021010297 dimerization interface [polypeptide binding]; other site 484021010298 putative catalytic residue [active] 484021010299 cation transport regulator; Reviewed; Region: chaB; PRK09582 484021010300 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 484021010301 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 484021010302 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 484021010303 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484021010304 hypothetical protein; Provisional; Region: PRK10941 484021010305 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 484021010306 hypothetical protein; Provisional; Region: PRK10278 484021010307 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 484021010308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021010309 peptide chain release factor 1; Validated; Region: prfA; PRK00591 484021010310 This domain is found in peptide chain release factors; Region: PCRF; smart00937 484021010311 RF-1 domain; Region: RF-1; pfam00472 484021010312 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 484021010313 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 484021010314 tRNA; other site 484021010315 putative tRNA binding site [nucleotide binding]; other site 484021010316 putative NADP binding site [chemical binding]; other site 484021010317 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 484021010318 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 484021010319 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 484021010320 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 484021010321 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484021010322 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 484021010323 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 484021010324 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 484021010325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021010326 active site 484021010327 putative transporter; Provisional; Region: PRK11660 484021010328 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 484021010329 Sulfate transporter family; Region: Sulfate_transp; pfam00916 484021010330 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 484021010331 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 484021010332 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 484021010333 hypothetical protein; Provisional; Region: PRK10692 484021010334 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 484021010335 putative active site [active] 484021010336 catalytic residue [active] 484021010337 GTP-binding protein YchF; Reviewed; Region: PRK09601 484021010338 YchF GTPase; Region: YchF; cd01900 484021010339 G1 box; other site 484021010340 GTP/Mg2+ binding site [chemical binding]; other site 484021010341 Switch I region; other site 484021010342 G2 box; other site 484021010343 Switch II region; other site 484021010344 G3 box; other site 484021010345 G4 box; other site 484021010346 G5 box; other site 484021010347 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 484021010348 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 484021010349 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 484021010350 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 484021010351 putative ligand binding site [chemical binding]; other site 484021010352 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 484021010353 ImpA domain protein; Region: DUF3702; pfam12486 484021010354 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 484021010355 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 484021010356 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 484021010357 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 484021010358 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 484021010359 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 484021010360 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 484021010361 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 484021010362 PAAR motif; Region: PAAR_motif; pfam05488 484021010363 Uncharacterized conserved protein [Function unknown]; Region: COG1262 484021010364 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 484021010365 Uncharacterized conserved protein [Function unknown]; Region: COG1262 484021010366 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 484021010367 Uncharacterized conserved protein [Function unknown]; Region: COG1262 484021010368 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 484021010369 Uncharacterized conserved protein [Function unknown]; Region: COG1262 484021010370 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 484021010371 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 484021010372 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 484021010373 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 484021010374 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 484021010375 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 484021010376 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 484021010377 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484021010378 ligand binding site [chemical binding]; other site 484021010379 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 484021010380 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 484021010381 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 484021010382 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 484021010383 putative active site pocket [active] 484021010384 dimerization interface [polypeptide binding]; other site 484021010385 putative catalytic residue [active] 484021010386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 484021010387 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 484021010388 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484021010389 active site 484021010390 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484021010391 DNA-binding site [nucleotide binding]; DNA binding site 484021010392 RNA-binding motif; other site 484021010393 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021010394 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010395 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 484021010396 putative dimerization interface [polypeptide binding]; other site 484021010397 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 484021010398 citrate-proton symporter; Provisional; Region: PRK15075 484021010399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021010400 putative substrate translocation pore; other site 484021010401 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 484021010402 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010403 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021010404 dimerization interface [polypeptide binding]; other site 484021010405 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021010406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021010407 Coenzyme A binding pocket [chemical binding]; other site 484021010408 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 484021010409 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 484021010410 active site 484021010411 substrate-binding site [chemical binding]; other site 484021010412 metal-binding site [ion binding] 484021010413 ATP binding site [chemical binding]; other site 484021010414 cell density-dependent motility repressor; Provisional; Region: PRK10082 484021010415 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010416 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021010417 dimerization interface [polypeptide binding]; other site 484021010418 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 484021010419 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 484021010420 Walker A/P-loop; other site 484021010421 ATP binding site [chemical binding]; other site 484021010422 Q-loop/lid; other site 484021010423 ABC transporter signature motif; other site 484021010424 Walker B; other site 484021010425 D-loop; other site 484021010426 H-loop/switch region; other site 484021010427 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 484021010428 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 484021010429 Walker A/P-loop; other site 484021010430 ATP binding site [chemical binding]; other site 484021010431 Q-loop/lid; other site 484021010432 ABC transporter signature motif; other site 484021010433 Walker B; other site 484021010434 D-loop; other site 484021010435 H-loop/switch region; other site 484021010436 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 484021010437 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 484021010438 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 484021010439 TM-ABC transporter signature motif; other site 484021010440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021010441 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 484021010442 TM-ABC transporter signature motif; other site 484021010443 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 484021010444 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 484021010445 dimerization interface [polypeptide binding]; other site 484021010446 ligand binding site [chemical binding]; other site 484021010447 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 484021010448 Pyruvate formate lyase 1; Region: PFL1; cd01678 484021010449 coenzyme A binding site [chemical binding]; other site 484021010450 active site 484021010451 catalytic residues [active] 484021010452 glycine loop; other site 484021010453 propionate/acetate kinase; Provisional; Region: PRK12379 484021010454 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 484021010455 threonine/serine transporter TdcC; Provisional; Region: PRK13629 484021010456 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484021010457 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 484021010458 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 484021010459 tetramer interface [polypeptide binding]; other site 484021010460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021010461 catalytic residue [active] 484021010462 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 484021010463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021010465 dimerization interface [polypeptide binding]; other site 484021010466 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 484021010467 potential frameshift: common BLAST hit: gi|146311997|ref|YP_001177071.1| putative ABC phosphate/phosphonate transporter, periplasmic ligand 484021010468 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 484021010469 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 484021010470 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 484021010471 putative di-iron ligands [ion binding]; other site 484021010472 Meiotically up-regulated gene 113; Region: MUG113; pfam13455 484021010473 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 484021010474 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 484021010475 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484021010476 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 484021010477 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 484021010478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 484021010479 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 484021010480 Uncharacterized conserved protein [Function unknown]; Region: COG2308 484021010481 trehalase; Provisional; Region: treA; PRK13271 484021010482 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 484021010483 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 484021010484 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021010485 N-terminal plug; other site 484021010486 ligand-binding site [chemical binding]; other site 484021010487 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 484021010488 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021010489 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021010490 catalytic residue [active] 484021010491 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 484021010492 dimer interface [polypeptide binding]; other site 484021010493 catalytic triad [active] 484021010494 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 484021010495 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 484021010496 TrkA-C domain; Region: TrkA_C; pfam02080 484021010497 Transporter associated domain; Region: CorC_HlyC; smart01091 484021010498 alanine racemase; Reviewed; Region: dadX; PRK03646 484021010499 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 484021010500 active site 484021010501 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484021010502 substrate binding site [chemical binding]; other site 484021010503 catalytic residues [active] 484021010504 dimer interface [polypeptide binding]; other site 484021010505 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 484021010506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484021010507 hydroxyglutarate oxidase; Provisional; Region: PRK11728 484021010508 SpoVR family protein; Provisional; Region: PRK11767 484021010509 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 484021010510 fatty acid metabolism regulator; Provisional; Region: PRK04984 484021010511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021010512 DNA-binding site [nucleotide binding]; DNA binding site 484021010513 FadR C-terminal domain; Region: FadR_C; pfam07840 484021010514 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 484021010515 transmembrane helices; other site 484021010516 disulfide bond formation protein B; Provisional; Region: PRK01749 484021010517 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 484021010518 hypothetical protein; Provisional; Region: PRK05170 484021010519 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 484021010520 hypothetical protein; Provisional; Region: PRK10691 484021010521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 484021010522 septum formation inhibitor; Reviewed; Region: minC; PRK03511 484021010523 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 484021010524 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 484021010525 cell division inhibitor MinD; Provisional; Region: PRK10818 484021010526 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 484021010527 Switch I; other site 484021010528 Switch II; other site 484021010529 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 484021010530 ribonuclease D; Provisional; Region: PRK10829 484021010531 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 484021010532 catalytic site [active] 484021010533 putative active site [active] 484021010534 putative substrate binding site [chemical binding]; other site 484021010535 Helicase and RNase D C-terminal; Region: HRDC; smart00341 484021010536 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 484021010537 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484021010538 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 484021010539 acyl-activating enzyme (AAE) consensus motif; other site 484021010540 putative AMP binding site [chemical binding]; other site 484021010541 putative active site [active] 484021010542 putative CoA binding site [chemical binding]; other site 484021010543 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 484021010544 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 484021010545 Glycoprotease family; Region: Peptidase_M22; pfam00814 484021010546 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 484021010547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 484021010548 DEAD_2; Region: DEAD_2; pfam06733 484021010549 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 484021010550 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 484021010551 homotrimer interaction site [polypeptide binding]; other site 484021010552 putative active site [active] 484021010553 hypothetical protein; Provisional; Region: PRK05114 484021010554 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 484021010555 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 484021010556 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 484021010557 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 484021010558 putative active site [active] 484021010559 putative CoA binding site [chemical binding]; other site 484021010560 nudix motif; other site 484021010561 metal binding site [ion binding]; metal-binding site 484021010562 L-serine deaminase; Provisional; Region: PRK15023 484021010563 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 484021010564 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 484021010565 phage resistance protein; Provisional; Region: PRK10551 484021010566 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 484021010567 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021010568 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 484021010569 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484021010570 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484021010571 Transporter associated domain; Region: CorC_HlyC; smart01091 484021010572 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 484021010573 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 484021010574 active pocket/dimerization site; other site 484021010575 active site 484021010576 phosphorylation site [posttranslational modification] 484021010577 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 484021010578 active site 484021010579 phosphorylation site [posttranslational modification] 484021010580 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 484021010581 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 484021010582 hypothetical protein; Provisional; Region: PRK02913 484021010583 hypothetical protein; Provisional; Region: PRK11469 484021010584 Domain of unknown function DUF; Region: DUF204; pfam02659 484021010585 Domain of unknown function DUF; Region: DUF204; pfam02659 484021010586 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 484021010587 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021010588 S-adenosylmethionine binding site [chemical binding]; other site 484021010589 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 484021010590 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484021010591 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484021010592 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484021010593 DNA-binding site [nucleotide binding]; DNA binding site 484021010594 RNA-binding motif; other site 484021010595 YebO-like protein; Region: YebO; pfam13974 484021010596 PhoPQ regulatory protein; Provisional; Region: PRK10299 484021010597 YobH-like protein; Region: YobH; pfam13996 484021010598 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 484021010599 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021010600 dimerization interface [polypeptide binding]; other site 484021010601 putative Zn2+ binding site [ion binding]; other site 484021010602 putative DNA binding site [nucleotide binding]; other site 484021010603 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021010604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021010605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021010606 putative substrate translocation pore; other site 484021010607 heat shock protein HtpX; Provisional; Region: PRK05457 484021010608 carboxy-terminal protease; Provisional; Region: PRK11186 484021010609 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 484021010610 protein binding site [polypeptide binding]; other site 484021010611 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 484021010612 Catalytic dyad [active] 484021010613 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 484021010614 ProP expression regulator; Provisional; Region: PRK04950 484021010615 ProQ/FINO family; Region: ProQ; pfam04352 484021010616 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 484021010617 GAF domain; Region: GAF_2; pfam13185 484021010618 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 484021010619 Paraquat-inducible protein A; Region: PqiA; pfam04403 484021010620 Paraquat-inducible protein A; Region: PqiA; pfam04403 484021010621 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 484021010622 mce related protein; Region: MCE; pfam02470 484021010623 mce related protein; Region: MCE; pfam02470 484021010624 mce related protein; Region: MCE; pfam02470 484021010625 mce related protein; Region: MCE; pfam02470 484021010626 mce related protein; Region: MCE; pfam02470 484021010627 mce related protein; Region: MCE; pfam02470 484021010628 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 484021010629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021010630 S-adenosylmethionine binding site [chemical binding]; other site 484021010631 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 484021010632 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 484021010633 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 484021010634 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 484021010635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 484021010636 Protein of unknown function (DUF535); Region: DUF535; pfam04393 484021010637 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 484021010638 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 484021010639 CopC domain; Region: CopC; cl01012 484021010640 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 484021010641 exodeoxyribonuclease X; Provisional; Region: PRK07983 484021010642 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 484021010643 active site 484021010644 catalytic site [active] 484021010645 substrate binding site [chemical binding]; other site 484021010646 protease 2; Provisional; Region: PRK10115 484021010647 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484021010648 Protein of unknown function (DUF533); Region: DUF533; pfam04391 484021010649 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 484021010650 putative metal binding site [ion binding]; other site 484021010651 YebG protein; Region: YebG; pfam07130 484021010652 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 484021010653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484021010654 ATP-grasp domain; Region: ATP-grasp; pfam02222 484021010655 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 484021010656 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 484021010657 active site 484021010658 intersubunit interface [polypeptide binding]; other site 484021010659 catalytic residue [active] 484021010660 phosphogluconate dehydratase; Validated; Region: PRK09054 484021010661 6-phosphogluconate dehydratase; Region: edd; TIGR01196 484021010662 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 484021010663 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 484021010664 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 484021010665 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 484021010666 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021010667 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021010668 putative active site [active] 484021010669 pyruvate kinase; Provisional; Region: PRK05826 484021010670 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 484021010671 domain interfaces; other site 484021010672 active site 484021010673 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 484021010674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 484021010675 putative acyl-acceptor binding pocket; other site 484021010676 putative peptidase; Provisional; Region: PRK11649 484021010677 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 484021010678 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021010679 Peptidase family M23; Region: Peptidase_M23; pfam01551 484021010680 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 484021010681 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 484021010682 metal binding site [ion binding]; metal-binding site 484021010683 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 484021010684 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 484021010685 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 484021010686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021010687 ABC-ATPase subunit interface; other site 484021010688 dimer interface [polypeptide binding]; other site 484021010689 putative PBP binding regions; other site 484021010690 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 484021010691 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021010692 Walker A motif; other site 484021010693 ATP binding site [chemical binding]; other site 484021010694 Walker B motif; other site 484021010695 arginine finger; other site 484021010696 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 484021010697 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 484021010698 RuvA N terminal domain; Region: RuvA_N; pfam01330 484021010699 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 484021010700 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 484021010701 active site 484021010702 putative DNA-binding cleft [nucleotide binding]; other site 484021010703 dimer interface [polypeptide binding]; other site 484021010704 hypothetical protein; Validated; Region: PRK00110 484021010705 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 484021010706 nudix motif; other site 484021010707 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 484021010708 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 484021010709 dimer interface [polypeptide binding]; other site 484021010710 anticodon binding site; other site 484021010711 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 484021010712 homodimer interface [polypeptide binding]; other site 484021010713 motif 1; other site 484021010714 active site 484021010715 motif 2; other site 484021010716 GAD domain; Region: GAD; pfam02938 484021010717 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484021010718 active site 484021010719 motif 3; other site 484021010720 Isochorismatase family; Region: Isochorismatase; pfam00857 484021010721 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 484021010722 catalytic triad [active] 484021010723 conserved cis-peptide bond; other site 484021010724 hypothetical protein; Provisional; Region: PRK10302 484021010725 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 484021010726 Methyltransferase domain; Region: Methyltransf_31; pfam13847 484021010727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021010728 S-adenosylmethionine binding site [chemical binding]; other site 484021010729 Methyltransferase domain; Region: Methyltransf_23; pfam13489 484021010730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021010731 S-adenosylmethionine binding site [chemical binding]; other site 484021010732 copper homeostasis protein CutC; Provisional; Region: PRK11572 484021010733 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 484021010734 putative metal binding site [ion binding]; other site 484021010735 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 484021010736 arginyl-tRNA synthetase; Region: argS; TIGR00456 484021010737 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 484021010738 active site 484021010739 HIGH motif; other site 484021010740 KMSK motif region; other site 484021010741 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 484021010742 tRNA binding surface [nucleotide binding]; other site 484021010743 anticodon binding site; other site 484021010744 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 484021010745 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484021010746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021010747 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021010748 Ligand Binding Site [chemical binding]; other site 484021010749 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 484021010750 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 484021010751 active site 484021010752 homotetramer interface [polypeptide binding]; other site 484021010753 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 484021010754 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 484021010755 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021010756 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021010757 TM-ABC transporter signature motif; other site 484021010758 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 484021010759 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021010760 Walker A/P-loop; other site 484021010761 ATP binding site [chemical binding]; other site 484021010762 Q-loop/lid; other site 484021010763 ABC transporter signature motif; other site 484021010764 Walker B; other site 484021010765 D-loop; other site 484021010766 H-loop/switch region; other site 484021010767 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021010768 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 484021010769 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 484021010770 ligand binding site [chemical binding]; other site 484021010771 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 484021010772 Ferritin-like domain; Region: Ferritin; pfam00210 484021010773 ferroxidase diiron center [ion binding]; other site 484021010774 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484021010775 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 484021010776 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 484021010777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021010778 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021010779 putative substrate translocation pore; other site 484021010780 hypothetical protein; Provisional; Region: PRK09273 484021010781 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 484021010782 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 484021010783 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 484021010784 Ferritin-like domain; Region: Ferritin; pfam00210 484021010785 ferroxidase diiron center [ion binding]; other site 484021010786 probable metal-binding protein; Region: matur_matur; TIGR03853 484021010787 tyrosine transporter TyrP; Provisional; Region: PRK15132 484021010788 aromatic amino acid transport protein; Region: araaP; TIGR00837 484021010789 hypothetical protein; Provisional; Region: PRK10396 484021010790 yecA family protein; Region: ygfB_yecA; TIGR02292 484021010791 SEC-C motif; Region: SEC-C; pfam02810 484021010792 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 484021010793 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 484021010794 inhibitor site; inhibition site 484021010795 active site 484021010796 dimer interface [polypeptide binding]; other site 484021010797 catalytic residue [active] 484021010798 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 484021010799 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 484021010800 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 484021010801 GIY-YIG motif/motif A; other site 484021010802 active site 484021010803 catalytic site [active] 484021010804 putative DNA binding site [nucleotide binding]; other site 484021010805 metal binding site [ion binding]; metal-binding site 484021010806 UvrB/uvrC motif; Region: UVR; pfam02151 484021010807 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 484021010808 response regulator; Provisional; Region: PRK09483 484021010809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021010810 active site 484021010811 phosphorylation site [posttranslational modification] 484021010812 intermolecular recognition site; other site 484021010813 dimerization interface [polypeptide binding]; other site 484021010814 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021010815 DNA binding residues [nucleotide binding] 484021010816 dimerization interface [polypeptide binding]; other site 484021010817 hypothetical protein; Provisional; Region: PRK10613 484021010818 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 484021010819 Autoinducer binding domain; Region: Autoind_bind; pfam03472 484021010820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021010821 DNA binding residues [nucleotide binding] 484021010822 dimerization interface [polypeptide binding]; other site 484021010823 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 484021010824 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021010825 Walker A/P-loop; other site 484021010826 ATP binding site [chemical binding]; other site 484021010827 Q-loop/lid; other site 484021010828 ABC transporter signature motif; other site 484021010829 Walker B; other site 484021010830 D-loop; other site 484021010831 H-loop/switch region; other site 484021010832 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021010833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021010834 dimer interface [polypeptide binding]; other site 484021010835 conserved gate region; other site 484021010836 putative PBP binding loops; other site 484021010837 ABC-ATPase subunit interface; other site 484021010838 D-cysteine desulfhydrase; Validated; Region: PRK03910 484021010839 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 484021010840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021010841 catalytic residue [active] 484021010842 cystine transporter subunit; Provisional; Region: PRK11260 484021010843 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021010844 substrate binding pocket [chemical binding]; other site 484021010845 membrane-bound complex binding site; other site 484021010846 hinge residues; other site 484021010847 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 484021010848 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 484021010849 active site 484021010850 Na/Ca binding site [ion binding]; other site 484021010851 catalytic site [active] 484021010852 lipoprotein; Provisional; Region: PRK10397 484021010853 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 484021010854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021010855 DNA binding residues [nucleotide binding] 484021010856 dimerization interface [polypeptide binding]; other site 484021010857 hypothetical protein; Provisional; Region: PRK10708 484021010858 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 484021010859 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 484021010860 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021010861 metal binding site [ion binding]; metal-binding site 484021010862 active site 484021010863 I-site; other site 484021010864 hypothetical protein; Provisional; Region: PRK10062 484021010865 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 484021010866 EamA-like transporter family; Region: EamA; pfam00892 484021010867 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 484021010868 additional DNA contacts [nucleotide binding]; other site 484021010869 mismatch recognition site; other site 484021010870 active site 484021010871 zinc binding site [ion binding]; other site 484021010872 DNA intercalation site [nucleotide binding]; other site 484021010873 DNA cytosine methylase; Provisional; Region: PRK10458 484021010874 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 484021010875 cofactor binding site; other site 484021010876 DNA binding site [nucleotide binding] 484021010877 substrate interaction site [chemical binding]; other site 484021010878 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 484021010879 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021010880 Zn2+ binding site [ion binding]; other site 484021010881 Mg2+ binding site [ion binding]; other site 484021010882 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 484021010883 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 484021010884 trimer interface [polypeptide binding]; other site 484021010885 eyelet of channel; other site 484021010886 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 484021010887 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 484021010888 homotrimer interaction site [polypeptide binding]; other site 484021010889 putative active site [active] 484021010890 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021010891 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010892 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021010893 putative effector binding pocket; other site 484021010894 putative dimerization interface [polypeptide binding]; other site 484021010895 L,D-transpeptidase; Provisional; Region: PRK10190 484021010896 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484021010897 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 484021010898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021010899 dimerization interface [polypeptide binding]; other site 484021010900 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 484021010901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021010902 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 484021010903 putative dimerization interface [polypeptide binding]; other site 484021010904 AMP nucleosidase; Provisional; Region: PRK08292 484021010905 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 484021010906 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 484021010907 signal transduction protein PmrD; Provisional; Region: PRK15450 484021010908 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 484021010909 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 484021010910 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 484021010911 NADP binding site [chemical binding]; other site 484021010912 dimer interface [polypeptide binding]; other site 484021010913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021010914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021010915 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 484021010916 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 484021010917 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 484021010918 MATE family multidrug exporter; Provisional; Region: PRK10189 484021010919 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 484021010920 integrative and conjugative element 484021010921 integrase; Provisional; Region: PRK09692 484021010922 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 484021010923 active site 484021010924 Int/Topo IB signature motif; other site 484021010925 salicylate synthase Irp9; Reviewed; Region: PRK06772 484021010926 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 484021010927 muropeptide transporter; Validated; Region: ampG; cl17669 484021010928 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484021010929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021010930 Walker A/P-loop; other site 484021010931 ATP binding site [chemical binding]; other site 484021010932 Q-loop/lid; other site 484021010933 ABC transporter signature motif; other site 484021010934 Walker B; other site 484021010935 D-loop; other site 484021010936 H-loop/switch region; other site 484021010937 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021010938 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484021010939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021010940 Walker A/P-loop; other site 484021010941 ATP binding site [chemical binding]; other site 484021010942 Q-loop/lid; other site 484021010943 ABC transporter signature motif; other site 484021010944 Walker B; other site 484021010945 D-loop; other site 484021010946 H-loop/switch region; other site 484021010947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021010948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021010949 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 484021010950 Condensation domain; Region: Condensation; pfam00668 484021010951 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 484021010952 Nonribosomal peptide synthase; Region: NRPS; pfam08415 484021010953 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 484021010954 acyl-activating enzyme (AAE) consensus motif; other site 484021010955 AMP binding site [chemical binding]; other site 484021010956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021010957 S-adenosylmethionine binding site [chemical binding]; other site 484021010958 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 484021010959 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484021010960 Condensation domain; Region: Condensation; pfam00668 484021010961 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 484021010962 Nonribosomal peptide synthase; Region: NRPS; pfam08415 484021010963 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484021010964 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 484021010965 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 484021010966 active site 484021010967 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 484021010968 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 484021010969 Methyltransferase domain; Region: Methyltransf_12; pfam08242 484021010970 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 484021010971 KR domain; Region: KR; pfam08659 484021010972 NADP binding site [chemical binding]; other site 484021010973 active site 484021010974 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484021010975 Condensation domain; Region: Condensation; pfam00668 484021010976 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 484021010977 Nonribosomal peptide synthase; Region: NRPS; pfam08415 484021010978 Methyltransferase domain; Region: Methyltransf_12; pfam08242 484021010979 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 484021010980 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 484021010981 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 484021010982 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021010983 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 484021010984 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 484021010985 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 484021010986 acyl-activating enzyme (AAE) consensus motif; other site 484021010987 active site 484021010988 AMP binding site [chemical binding]; other site 484021010989 substrate binding site [chemical binding]; other site 484021010990 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 484021010991 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021010992 N-terminal plug; other site 484021010993 ligand-binding site [chemical binding]; other site 484021010994 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 484021010995 Protein of unknown function (DUF2857); Region: DUF2857; pfam11198 484021010996 Haemolysin expression modulating protein; Region: HHA; cl11501 484021010997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021010998 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 484021010999 Walker A motif; other site 484021011000 ATP binding site [chemical binding]; other site 484021011001 transposase/IS protein; Provisional; Region: PRK09183 484021011002 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 484021011003 Integrase core domain; Region: rve; pfam00665 484021011004 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 484021011005 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 484021011006 oligomeric interface; other site 484021011007 putative active site [active] 484021011008 homodimer interface [polypeptide binding]; other site 484021011009 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 484021011010 outer membrane receptor FepA; Provisional; Region: PRK13528 484021011011 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021011012 N-terminal plug; other site 484021011013 ligand-binding site [chemical binding]; other site 484021011014 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 484021011015 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 484021011016 homodimer interface [polypeptide binding]; other site 484021011017 active site 484021011018 TDP-binding site; other site 484021011019 acceptor substrate-binding pocket; other site 484021011020 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021011021 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484021011022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021011023 Walker A/P-loop; other site 484021011024 ATP binding site [chemical binding]; other site 484021011025 Q-loop/lid; other site 484021011026 ABC transporter signature motif; other site 484021011027 Walker B; other site 484021011028 D-loop; other site 484021011029 H-loop/switch region; other site 484021011030 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484021011031 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484021011032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021011033 Walker A/P-loop; other site 484021011034 ATP binding site [chemical binding]; other site 484021011035 Q-loop/lid; other site 484021011036 ABC transporter signature motif; other site 484021011037 Walker B; other site 484021011038 D-loop; other site 484021011039 H-loop/switch region; other site 484021011040 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 484021011041 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 484021011042 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 484021011043 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021011044 EamA-like transporter family; Region: EamA; pfam00892 484021011045 EamA-like transporter family; Region: EamA; pfam00892 484021011046 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315 484021011047 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021011048 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021011049 DNA binding residues [nucleotide binding] 484021011050 dimerization interface [polypeptide binding]; other site 484021011051 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021011052 DNA binding residues [nucleotide binding] 484021011053 Methyltransferase domain; Region: Methyltransf_23; pfam13489 484021011054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021011055 S-adenosylmethionine binding site [chemical binding]; other site 484021011056 Integrase core domain; Region: rve_3; cl15866 484021011057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484021011058 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021011059 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021011060 catalytic residue [active] 484021011061 TrbC/VIRB2 family; Region: TrbC; cl01583 484021011062 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 484021011063 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 484021011064 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 484021011065 P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791 484021011066 Type IV secretion system proteins; Region: T4SS; pfam07996 484021011067 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 484021011068 VirB8 protein; Region: VirB8; pfam04335 484021011069 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 484021011070 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 484021011071 VirB7 interaction site; other site 484021011072 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 484021011073 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 484021011074 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 484021011075 Walker A motif; other site 484021011076 hexamer interface [polypeptide binding]; other site 484021011077 ATP binding site [chemical binding]; other site 484021011078 Walker B motif; other site 484021011079 Cag pathogenicity island protein Cag12; Region: Cag12; pfam13117 484021011080 TrbM; Region: TrbM; pfam07424 484021011081 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 484021011082 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 484021011083 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 484021011084 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 484021011085 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 484021011086 ATP binding site [chemical binding]; other site 484021011087 substrate interface [chemical binding]; other site 484021011088 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 484021011089 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 484021011090 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 484021011091 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 484021011092 Helix-turn-helix domain; Region: HTH_20; pfam12840 484021011093 putative DNA binding site [nucleotide binding]; other site 484021011094 putative Zn2+ binding site [ion binding]; other site 484021011095 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 484021011096 active site 484021011097 substrate binding site [chemical binding]; other site 484021011098 ATP binding site [chemical binding]; other site 484021011099 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 484021011100 GAF domain; Region: GAF; pfam01590 484021011101 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021011102 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021011103 metal binding site [ion binding]; metal-binding site 484021011104 active site 484021011105 I-site; other site 484021011106 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 484021011107 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 484021011108 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484021011109 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011110 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021011111 dimerization interface [polypeptide binding]; other site 484021011112 substrate binding pocket [chemical binding]; other site 484021011113 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 484021011114 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 484021011115 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021011116 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021011117 metal binding site [ion binding]; metal-binding site 484021011118 active site 484021011119 I-site; other site 484021011120 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021011121 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 484021011122 shikimate transporter; Provisional; Region: PRK09952 484021011123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011124 putative substrate translocation pore; other site 484021011125 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 484021011126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021011127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011128 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021011129 putative effector binding pocket; other site 484021011130 dimerization interface [polypeptide binding]; other site 484021011131 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 484021011132 HPP family; Region: HPP; pfam04982 484021011133 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 484021011134 NAD binding site [chemical binding]; other site 484021011135 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 484021011136 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 484021011137 putative dimer interface [polypeptide binding]; other site 484021011138 active site pocket [active] 484021011139 putative cataytic base [active] 484021011140 cobalamin synthase; Reviewed; Region: cobS; PRK00235 484021011141 hypothetical protein; Provisional; Region: PRK05423 484021011142 Predicted membrane protein [Function unknown]; Region: COG1289 484021011143 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484021011144 DNA gyrase inhibitor; Provisional; Region: PRK10016 484021011145 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 484021011146 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 484021011147 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 484021011148 exonuclease I; Provisional; Region: sbcB; PRK11779 484021011149 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 484021011150 active site 484021011151 catalytic site [active] 484021011152 substrate binding site [chemical binding]; other site 484021011153 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 484021011154 elongation factor G; Reviewed; Region: PRK00007 484021011155 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 484021011156 G1 box; other site 484021011157 putative GEF interaction site [polypeptide binding]; other site 484021011158 GTP/Mg2+ binding site [chemical binding]; other site 484021011159 Switch I region; other site 484021011160 G2 box; other site 484021011161 G3 box; other site 484021011162 Switch II region; other site 484021011163 G4 box; other site 484021011164 G5 box; other site 484021011165 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 484021011166 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 484021011167 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 484021011168 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021011169 dimerization interface [polypeptide binding]; other site 484021011170 putative DNA binding site [nucleotide binding]; other site 484021011171 putative Zn2+ binding site [ion binding]; other site 484021011172 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484021011173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011174 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021011175 dimerization interface [polypeptide binding]; other site 484021011176 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484021011177 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 484021011178 putative NAD(P) binding site [chemical binding]; other site 484021011179 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 484021011180 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 484021011181 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 484021011182 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 484021011183 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 484021011184 NAD binding site [chemical binding]; other site 484021011185 dimerization interface [polypeptide binding]; other site 484021011186 product binding site; other site 484021011187 substrate binding site [chemical binding]; other site 484021011188 zinc binding site [ion binding]; other site 484021011189 catalytic residues [active] 484021011190 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 484021011191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021011192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021011193 homodimer interface [polypeptide binding]; other site 484021011194 catalytic residue [active] 484021011195 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 484021011196 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021011197 active site 484021011198 motif I; other site 484021011199 motif II; other site 484021011200 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 484021011201 putative active site pocket [active] 484021011202 4-fold oligomerization interface [polypeptide binding]; other site 484021011203 metal binding residues [ion binding]; metal-binding site 484021011204 3-fold/trimer interface [polypeptide binding]; other site 484021011205 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 484021011206 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 484021011207 putative active site [active] 484021011208 oxyanion strand; other site 484021011209 catalytic triad [active] 484021011210 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 484021011211 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 484021011212 catalytic residues [active] 484021011213 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 484021011214 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 484021011215 substrate binding site [chemical binding]; other site 484021011216 glutamase interaction surface [polypeptide binding]; other site 484021011217 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 484021011218 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 484021011219 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 484021011220 metal binding site [ion binding]; metal-binding site 484021011221 Predicted membrane protein [Function unknown]; Region: COG2246 484021011222 GtrA-like protein; Region: GtrA; pfam04138 484021011223 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 484021011224 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 484021011225 Ligand binding site; other site 484021011226 Putative Catalytic site; other site 484021011227 DXD motif; other site 484021011228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484021011229 active site 484021011230 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 484021011231 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484021011232 putative ADP-binding pocket [chemical binding]; other site 484021011233 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 484021011234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484021011235 active site 484021011236 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 484021011237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484021011238 UDP-galactopyranose mutase; Region: GLF; pfam03275 484021011239 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 484021011240 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 484021011241 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 484021011242 Ligand binding site; other site 484021011243 metal-binding site 484021011244 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 484021011245 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 484021011246 Walker A/P-loop; other site 484021011247 ATP binding site [chemical binding]; other site 484021011248 Q-loop/lid; other site 484021011249 ABC transporter signature motif; other site 484021011250 Walker B; other site 484021011251 D-loop; other site 484021011252 H-loop/switch region; other site 484021011253 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 484021011254 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484021011255 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484021011256 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 484021011257 putative NAD(P) binding site [chemical binding]; other site 484021011258 active site 484021011259 putative substrate binding site [chemical binding]; other site 484021011260 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 484021011261 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 484021011262 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 484021011263 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 484021011264 phosphomannomutase CpsG; Provisional; Region: PRK15414 484021011265 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 484021011266 active site 484021011267 substrate binding site [chemical binding]; other site 484021011268 metal binding site [ion binding]; metal-binding site 484021011269 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 484021011270 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 484021011271 Substrate binding site; other site 484021011272 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 484021011273 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 484021011274 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 484021011275 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 484021011276 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 484021011277 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 484021011278 putative glycosyl transferase; Provisional; Region: PRK10307 484021011279 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 484021011280 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 484021011281 active site 484021011282 GDP-Mannose binding site [chemical binding]; other site 484021011283 dimer interface [polypeptide binding]; other site 484021011284 modified nudix motif 484021011285 metal binding site [ion binding]; metal-binding site 484021011286 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 484021011287 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 484021011288 NADP binding site [chemical binding]; other site 484021011289 active site 484021011290 putative substrate binding site [chemical binding]; other site 484021011291 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 484021011292 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 484021011293 NADP-binding site; other site 484021011294 homotetramer interface [polypeptide binding]; other site 484021011295 substrate binding site [chemical binding]; other site 484021011296 homodimer interface [polypeptide binding]; other site 484021011297 active site 484021011298 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 484021011299 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 484021011300 trimer interface [polypeptide binding]; other site 484021011301 active site 484021011302 substrate binding site [chemical binding]; other site 484021011303 CoA binding site [chemical binding]; other site 484021011304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484021011305 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484021011306 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 484021011307 O-Antigen ligase; Region: Wzy_C; pfam04932 484021011308 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 484021011309 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 484021011310 tyrosine kinase; Provisional; Region: PRK11519 484021011311 Chain length determinant protein; Region: Wzz; pfam02706 484021011312 Chain length determinant protein; Region: Wzz; cl15801 484021011313 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 484021011314 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 484021011315 Nucleotide binding site [chemical binding]; other site 484021011316 DTAP/Switch II; other site 484021011317 Switch I; other site 484021011318 Low molecular weight phosphatase family; Region: LMWPc; cd00115 484021011319 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 484021011320 active site 484021011321 polysaccharide export protein Wza; Provisional; Region: PRK15078 484021011322 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 484021011323 SLBB domain; Region: SLBB; pfam10531 484021011324 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 484021011325 Acid phosphatase homologues; Region: acidPPc; smart00014 484021011326 active site 484021011327 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 484021011328 active site 484021011329 tetramer interface; other site 484021011330 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 484021011331 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484021011332 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484021011333 Transporter associated domain; Region: CorC_HlyC; smart01091 484021011334 putative assembly protein; Provisional; Region: PRK10833 484021011335 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 484021011336 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484021011337 trimer interface [polypeptide binding]; other site 484021011338 active site 484021011339 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 484021011340 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 484021011341 ATP-binding site [chemical binding]; other site 484021011342 Sugar specificity; other site 484021011343 Pyrimidine base specificity; other site 484021011344 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 484021011345 AlkA N-terminal domain; Region: AlkA_N; pfam06029 484021011346 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484021011347 minor groove reading motif; other site 484021011348 helix-hairpin-helix signature motif; other site 484021011349 substrate binding pocket [chemical binding]; other site 484021011350 active site 484021011351 putative chaperone; Provisional; Region: PRK11678 484021011352 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 484021011353 nucleotide binding site [chemical binding]; other site 484021011354 putative NEF/HSP70 interaction site [polypeptide binding]; other site 484021011355 SBD interface [polypeptide binding]; other site 484021011356 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 484021011357 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 484021011358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 484021011359 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021011360 dimer interface [polypeptide binding]; other site 484021011361 phosphorylation site [posttranslational modification] 484021011362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021011363 ATP binding site [chemical binding]; other site 484021011364 Mg2+ binding site [ion binding]; other site 484021011365 G-X-G motif; other site 484021011366 transcriptional regulator PhoB; Provisional; Region: PRK10161 484021011367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021011368 active site 484021011369 phosphorylation site [posttranslational modification] 484021011370 intermolecular recognition site; other site 484021011371 dimerization interface [polypeptide binding]; other site 484021011372 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 484021011373 DNA binding site [nucleotide binding] 484021011374 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 484021011375 DNA binding residues [nucleotide binding] 484021011376 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484021011377 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 484021011378 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 484021011379 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021011380 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021011381 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 484021011382 Protein export membrane protein; Region: SecD_SecF; cl14618 484021011383 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 484021011384 putative transporter; Provisional; Region: PRK10504 484021011385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011386 putative substrate translocation pore; other site 484021011387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011388 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 484021011389 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021011390 dimerization interface [polypeptide binding]; other site 484021011391 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021011392 dimer interface [polypeptide binding]; other site 484021011393 phosphorylation site [posttranslational modification] 484021011394 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021011395 ATP binding site [chemical binding]; other site 484021011396 Mg2+ binding site [ion binding]; other site 484021011397 G-X-G motif; other site 484021011398 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 484021011399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021011400 active site 484021011401 phosphorylation site [posttranslational modification] 484021011402 intermolecular recognition site; other site 484021011403 dimerization interface [polypeptide binding]; other site 484021011404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021011405 DNA binding site [nucleotide binding] 484021011406 putative protease; Provisional; Region: PRK15452 484021011407 Peptidase family U32; Region: Peptidase_U32; pfam01136 484021011408 lipid kinase; Reviewed; Region: PRK13054 484021011409 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 484021011410 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484021011411 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021011412 Walker A/P-loop; other site 484021011413 ATP binding site [chemical binding]; other site 484021011414 Q-loop/lid; other site 484021011415 ABC transporter signature motif; other site 484021011416 Walker B; other site 484021011417 D-loop; other site 484021011418 H-loop/switch region; other site 484021011419 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484021011420 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021011421 Walker A/P-loop; other site 484021011422 ATP binding site [chemical binding]; other site 484021011423 Q-loop/lid; other site 484021011424 ABC transporter signature motif; other site 484021011425 Walker B; other site 484021011426 D-loop; other site 484021011427 H-loop/switch region; other site 484021011428 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021011429 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484021011430 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021011431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021011432 dimer interface [polypeptide binding]; other site 484021011433 conserved gate region; other site 484021011434 ABC-ATPase subunit interface; other site 484021011435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021011436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021011437 dimer interface [polypeptide binding]; other site 484021011438 conserved gate region; other site 484021011439 putative PBP binding loops; other site 484021011440 ABC-ATPase subunit interface; other site 484021011441 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021011442 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 484021011443 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 484021011444 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 484021011445 putative active site pocket [active] 484021011446 metal binding site [ion binding]; metal-binding site 484021011447 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484021011448 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 484021011449 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021011450 motif II; other site 484021011451 polyol permease family; Region: 2A0118; TIGR00897 484021011452 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011453 putative substrate translocation pore; other site 484021011454 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 484021011455 N- and C-terminal domain interface [polypeptide binding]; other site 484021011456 D-xylulose kinase; Region: XylB; TIGR01312 484021011457 active site 484021011458 MgATP binding site [chemical binding]; other site 484021011459 catalytic site [active] 484021011460 metal binding site [ion binding]; metal-binding site 484021011461 xylulose binding site [chemical binding]; other site 484021011462 homodimer interface [polypeptide binding]; other site 484021011463 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 484021011464 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 484021011465 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 484021011466 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 484021011467 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 484021011468 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 484021011469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021011470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021011471 DNA binding site [nucleotide binding] 484021011472 domain linker motif; other site 484021011473 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 484021011474 dimerization interface [polypeptide binding]; other site 484021011475 ligand binding site [chemical binding]; other site 484021011476 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 484021011477 classical (c) SDRs; Region: SDR_c; cd05233 484021011478 NAD(P) binding site [chemical binding]; other site 484021011479 active site 484021011480 Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782 484021011481 FGGY-family pentulose kinase; Region: 5C_CHO_kinase; TIGR01315 484021011482 N- and C-terminal domain interface [polypeptide binding]; other site 484021011483 active site 484021011484 MgATP binding site [chemical binding]; other site 484021011485 catalytic site [active] 484021011486 metal binding site [ion binding]; metal-binding site 484021011487 carbohydrate binding site [chemical binding]; other site 484021011488 putative homodimer interface [polypeptide binding]; other site 484021011489 polyol permease family; Region: 2A0118; TIGR00897 484021011490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011491 putative substrate translocation pore; other site 484021011492 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 484021011493 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 484021011494 putative active site; other site 484021011495 catalytic residue [active] 484021011496 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 484021011497 dimer interface [polypeptide binding]; other site 484021011498 substrate binding site [chemical binding]; other site 484021011499 ATP binding site [chemical binding]; other site 484021011500 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 484021011501 substrate binding site [chemical binding]; other site 484021011502 multimerization interface [polypeptide binding]; other site 484021011503 ATP binding site [chemical binding]; other site 484021011504 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 484021011505 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 484021011506 Alginate lyase; Region: Alginate_lyase; pfam05426 484021011507 Integrase core domain; Region: rve; pfam00665 484021011508 SCP-2 sterol transfer family; Region: SCP2; pfam02036 484021011509 Transcriptional regulator; Region: Rrf2; cl17282 484021011510 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 484021011511 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484021011512 SCP-2 sterol transfer family; Region: SCP2; pfam02036 484021011513 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 484021011514 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011515 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021011516 dimerization interface [polypeptide binding]; other site 484021011517 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 484021011518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484021011519 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 484021011520 active site 484021011521 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 484021011522 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 484021011523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021011524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011525 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021011526 putative effector binding pocket; other site 484021011527 dimerization interface [polypeptide binding]; other site 484021011528 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 484021011529 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021011530 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021011531 Coenzyme A binding pocket [chemical binding]; other site 484021011532 antiporter inner membrane protein; Provisional; Region: PRK11670 484021011533 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 484021011534 Walker A motif; other site 484021011535 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 484021011536 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 484021011537 active site 484021011538 HIGH motif; other site 484021011539 KMSKS motif; other site 484021011540 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 484021011541 tRNA binding surface [nucleotide binding]; other site 484021011542 anticodon binding site; other site 484021011543 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 484021011544 dimer interface [polypeptide binding]; other site 484021011545 putative tRNA-binding site [nucleotide binding]; other site 484021011546 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 484021011547 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 484021011548 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 484021011549 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 484021011550 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021011551 active site 484021011552 phosphorylation site [posttranslational modification] 484021011553 intermolecular recognition site; other site 484021011554 dimerization interface [polypeptide binding]; other site 484021011555 LytTr DNA-binding domain; Region: LytTR; pfam04397 484021011556 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 484021011557 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 484021011558 GAF domain; Region: GAF; pfam01590 484021011559 Histidine kinase; Region: His_kinase; pfam06580 484021011560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021011561 ATP binding site [chemical binding]; other site 484021011562 Mg2+ binding site [ion binding]; other site 484021011563 G-X-G motif; other site 484021011564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021011565 dimer interface [polypeptide binding]; other site 484021011566 conserved gate region; other site 484021011567 putative PBP binding loops; other site 484021011568 ABC-ATPase subunit interface; other site 484021011569 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 484021011570 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 484021011571 Walker A/P-loop; other site 484021011572 ATP binding site [chemical binding]; other site 484021011573 Q-loop/lid; other site 484021011574 ABC transporter signature motif; other site 484021011575 Walker B; other site 484021011576 D-loop; other site 484021011577 H-loop/switch region; other site 484021011578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 484021011579 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021011580 conserved gate region; other site 484021011581 ABC-ATPase subunit interface; other site 484021011582 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 484021011583 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 484021011584 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 484021011585 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 484021011586 D-lactate dehydrogenase; Provisional; Region: PRK11183 484021011587 FAD binding domain; Region: FAD_binding_4; pfam01565 484021011588 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 484021011589 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 484021011590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021011591 Coenzyme A binding pocket [chemical binding]; other site 484021011592 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 484021011593 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 484021011594 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 484021011595 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484021011596 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484021011597 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 484021011598 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 484021011599 beta-galactosidase; Region: BGL; TIGR03356 484021011600 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 484021011601 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021011602 active site turn [active] 484021011603 phosphorylation site [posttranslational modification] 484021011604 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021011605 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 484021011606 HPr interaction site; other site 484021011607 glycerol kinase (GK) interaction site [polypeptide binding]; other site 484021011608 active site 484021011609 phosphorylation site [posttranslational modification] 484021011610 transcriptional antiterminator BglG; Provisional; Region: PRK09772 484021011611 CAT RNA binding domain; Region: CAT_RBD; smart01061 484021011612 PRD domain; Region: PRD; pfam00874 484021011613 PRD domain; Region: PRD; pfam00874 484021011614 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 484021011615 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 484021011616 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 484021011617 FMN binding site [chemical binding]; other site 484021011618 active site 484021011619 catalytic residues [active] 484021011620 substrate binding site [chemical binding]; other site 484021011621 hypothetical protein; Provisional; Region: PRK01821 484021011622 hypothetical protein; Provisional; Region: PRK10711 484021011623 cytidine deaminase; Provisional; Region: PRK09027 484021011624 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 484021011625 active site 484021011626 catalytic motif [active] 484021011627 Zn binding site [ion binding]; other site 484021011628 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 484021011629 active site 484021011630 catalytic motif [active] 484021011631 Zn binding site [ion binding]; other site 484021011632 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484021011633 putative active site [active] 484021011634 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021011635 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021011636 TM-ABC transporter signature motif; other site 484021011637 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021011638 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 484021011639 Walker A/P-loop; other site 484021011640 ATP binding site [chemical binding]; other site 484021011641 Q-loop/lid; other site 484021011642 ABC transporter signature motif; other site 484021011643 Walker B; other site 484021011644 D-loop; other site 484021011645 H-loop/switch region; other site 484021011646 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021011647 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 484021011648 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 484021011649 ligand binding site [chemical binding]; other site 484021011650 calcium binding site [ion binding]; other site 484021011651 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 484021011652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021011653 DNA binding site [nucleotide binding] 484021011654 domain linker motif; other site 484021011655 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 484021011656 dimerization interface (closed form) [polypeptide binding]; other site 484021011657 ligand binding site [chemical binding]; other site 484021011658 Predicted membrane protein [Function unknown]; Region: COG2311 484021011659 hypothetical protein; Provisional; Region: PRK10835 484021011660 GTP cyclohydrolase I; Provisional; Region: PLN03044 484021011661 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 484021011662 active site 484021011663 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 484021011664 S-formylglutathione hydrolase; Region: PLN02442 484021011665 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 484021011666 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021011667 N-terminal plug; other site 484021011668 ligand-binding site [chemical binding]; other site 484021011669 lysine transporter; Provisional; Region: PRK10836 484021011670 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 484021011671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011672 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 484021011673 putative dimerization interface [polypeptide binding]; other site 484021011674 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 484021011675 endonuclease IV; Provisional; Region: PRK01060 484021011676 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 484021011677 DNA interaction; other site 484021011678 Metal-binding active site; metal-binding site 484021011679 AP (apurinic/apyrimidinic) site pocket; other site 484021011680 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 484021011681 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 484021011682 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 484021011683 active site 484021011684 P-loop; other site 484021011685 phosphorylation site [posttranslational modification] 484021011686 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 484021011687 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 484021011688 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 484021011689 putative substrate binding site [chemical binding]; other site 484021011690 putative ATP binding site [chemical binding]; other site 484021011691 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 484021011692 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021011693 active site 484021011694 phosphorylation site [posttranslational modification] 484021011695 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484021011696 dimerization domain swap beta strand [polypeptide binding]; other site 484021011697 regulatory protein interface [polypeptide binding]; other site 484021011698 active site 484021011699 regulatory phosphorylation site [posttranslational modification]; other site 484021011700 sugar efflux transporter B; Provisional; Region: PRK15011 484021011701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011702 putative substrate translocation pore; other site 484021011703 Flagellin N-methylase; Region: FliB; cl00497 484021011704 elongation factor P; Provisional; Region: PRK04542 484021011705 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 484021011706 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 484021011707 RNA binding site [nucleotide binding]; other site 484021011708 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 484021011709 RNA binding site [nucleotide binding]; other site 484021011710 mannonate dehydratase; Provisional; Region: PRK03906 484021011711 mannonate dehydratase; Region: uxuA; TIGR00695 484021011712 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 484021011713 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 484021011714 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 484021011715 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 484021011716 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 484021011717 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 484021011718 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484021011719 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 484021011720 active site 484021011721 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 484021011722 NlpC/P60 family; Region: NLPC_P60; pfam00877 484021011723 phage resistance protein; Provisional; Region: PRK10551 484021011724 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 484021011725 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021011726 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 484021011727 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 484021011728 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 484021011729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021011730 dimer interface [polypeptide binding]; other site 484021011731 conserved gate region; other site 484021011732 putative PBP binding loops; other site 484021011733 ABC-ATPase subunit interface; other site 484021011734 microcin C ABC transporter permease; Provisional; Region: PRK15021 484021011735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021011736 dimer interface [polypeptide binding]; other site 484021011737 conserved gate region; other site 484021011738 ABC-ATPase subunit interface; other site 484021011739 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 484021011740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021011741 Walker A/P-loop; other site 484021011742 ATP binding site [chemical binding]; other site 484021011743 Q-loop/lid; other site 484021011744 ABC transporter signature motif; other site 484021011745 Walker B; other site 484021011746 D-loop; other site 484021011747 H-loop/switch region; other site 484021011748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021011749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021011750 Walker A/P-loop; other site 484021011751 ATP binding site [chemical binding]; other site 484021011752 Q-loop/lid; other site 484021011753 ABC transporter signature motif; other site 484021011754 Walker B; other site 484021011755 D-loop; other site 484021011756 H-loop/switch region; other site 484021011757 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484021011758 hypothetical protein; Provisional; Region: PRK11835 484021011759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011760 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 484021011761 putative substrate translocation pore; other site 484021011762 potential protein location (conserved hypothetical protein) that overlaps protein (16S pseudouridylate 516 synthase) 484021011763 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 484021011764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021011765 RNA binding surface [nucleotide binding]; other site 484021011766 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 484021011767 active site 484021011768 uracil binding [chemical binding]; other site 484021011769 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 484021011770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021011771 ATP binding site [chemical binding]; other site 484021011772 putative Mg++ binding site [ion binding]; other site 484021011773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021011774 nucleotide binding region [chemical binding]; other site 484021011775 ATP-binding site [chemical binding]; other site 484021011776 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 484021011777 5S rRNA interface [nucleotide binding]; other site 484021011778 CTC domain interface [polypeptide binding]; other site 484021011779 L16 interface [polypeptide binding]; other site 484021011780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021011781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021011782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021011783 dimerization interface [polypeptide binding]; other site 484021011784 Beta-lactamase; Region: Beta-lactamase; pfam00144 484021011785 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 484021011786 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 484021011787 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484021011788 dimer interface [polypeptide binding]; other site 484021011789 ADP-ribose binding site [chemical binding]; other site 484021011790 active site 484021011791 nudix motif; other site 484021011792 metal binding site [ion binding]; metal-binding site 484021011793 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021011794 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021011795 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021011796 Nucleoid-associated protein [General function prediction only]; Region: COG3081 484021011797 nucleoid-associated protein NdpA; Validated; Region: PRK00378 484021011798 hypothetical protein; Provisional; Region: PRK13689 484021011799 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 484021011800 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 484021011801 Sulfatase; Region: Sulfatase; cl17466 484021011802 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484021011803 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 484021011804 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 484021011805 secondary substrate binding site; other site 484021011806 primary substrate binding site; other site 484021011807 inhibition loop; other site 484021011808 dimerization interface [polypeptide binding]; other site 484021011809 malate:quinone oxidoreductase; Validated; Region: PRK05257 484021011810 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 484021011811 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 484021011812 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 484021011813 Sulfate transporter family; Region: Sulfate_transp; pfam00916 484021011814 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 484021011815 MgtE intracellular N domain; Region: MgtE_N; smart00924 484021011816 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 484021011817 Divalent cation transporter; Region: MgtE; cl00786 484021011818 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 484021011819 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 484021011820 Walker A/P-loop; other site 484021011821 ATP binding site [chemical binding]; other site 484021011822 Q-loop/lid; other site 484021011823 ABC transporter signature motif; other site 484021011824 Walker B; other site 484021011825 D-loop; other site 484021011826 H-loop/switch region; other site 484021011827 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 484021011828 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 484021011829 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 484021011830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021011831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021011832 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 484021011833 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484021011834 DNA binding site [nucleotide binding] 484021011835 active site 484021011836 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 484021011837 ApbE family; Region: ApbE; pfam02424 484021011838 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 484021011839 outer membrane porin protein C; Provisional; Region: PRK10554 484021011840 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 484021011841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021011842 ATP binding site [chemical binding]; other site 484021011843 Mg2+ binding site [ion binding]; other site 484021011844 G-X-G motif; other site 484021011845 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 484021011846 putative binding surface; other site 484021011847 active site 484021011848 transcriptional regulator RcsB; Provisional; Region: PRK10840 484021011849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021011850 active site 484021011851 phosphorylation site [posttranslational modification] 484021011852 intermolecular recognition site; other site 484021011853 dimerization interface [polypeptide binding]; other site 484021011854 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021011855 DNA binding residues [nucleotide binding] 484021011856 dimerization interface [polypeptide binding]; other site 484021011857 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 484021011858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021011859 dimer interface [polypeptide binding]; other site 484021011860 phosphorylation site [posttranslational modification] 484021011861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021011862 ATP binding site [chemical binding]; other site 484021011863 Mg2+ binding site [ion binding]; other site 484021011864 G-X-G motif; other site 484021011865 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 484021011866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021011867 active site 484021011868 phosphorylation site [posttranslational modification] 484021011869 intermolecular recognition site; other site 484021011870 dimerization interface [polypeptide binding]; other site 484021011871 DNA gyrase subunit A; Validated; Region: PRK05560 484021011872 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 484021011873 CAP-like domain; other site 484021011874 active site 484021011875 primary dimer interface [polypeptide binding]; other site 484021011876 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484021011877 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484021011878 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484021011879 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484021011880 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484021011881 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484021011882 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 484021011883 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021011884 S-adenosylmethionine binding site [chemical binding]; other site 484021011885 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 484021011886 ATP cone domain; Region: ATP-cone; pfam03477 484021011887 Class I ribonucleotide reductase; Region: RNR_I; cd01679 484021011888 active site 484021011889 dimer interface [polypeptide binding]; other site 484021011890 catalytic residues [active] 484021011891 effector binding site; other site 484021011892 R2 peptide binding site; other site 484021011893 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 484021011894 dimer interface [polypeptide binding]; other site 484021011895 putative radical transfer pathway; other site 484021011896 diiron center [ion binding]; other site 484021011897 tyrosyl radical; other site 484021011898 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 484021011899 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021011900 catalytic loop [active] 484021011901 iron binding site [ion binding]; other site 484021011902 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 484021011903 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 484021011904 active site 484021011905 catalytic site [active] 484021011906 metal binding site [ion binding]; metal-binding site 484021011907 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 484021011908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011909 putative substrate translocation pore; other site 484021011910 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 484021011911 hydroxyglutarate oxidase; Provisional; Region: PRK11728 484021011912 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 484021011913 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 484021011914 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 484021011915 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 484021011916 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 484021011917 Cysteine-rich domain; Region: CCG; pfam02754 484021011918 Cysteine-rich domain; Region: CCG; pfam02754 484021011919 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 484021011920 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 484021011921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021011922 putative substrate translocation pore; other site 484021011923 L-rhamnonate dehydratase; Provisional; Region: PRK15440 484021011924 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 484021011925 putative active site pocket [active] 484021011926 putative metal binding site [ion binding]; other site 484021011927 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 484021011928 Transcriptional regulator [Transcription]; Region: IclR; COG1414 484021011929 Bacterial transcriptional regulator; Region: IclR; pfam01614 484021011930 hypothetical protein; Provisional; Region: PRK03673 484021011931 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 484021011932 putative MPT binding site; other site 484021011933 Competence-damaged protein; Region: CinA; cl00666 484021011934 YfaZ precursor; Region: YfaZ; pfam07437 484021011935 Organic solvent tolerance protein; Region: OstA_C; pfam04453 484021011936 putative transposase; Provisional; Region: PRK09857 484021011937 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021011938 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 484021011939 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 484021011940 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 484021011941 acyl-activating enzyme (AAE) consensus motif; other site 484021011942 putative AMP binding site [chemical binding]; other site 484021011943 putative active site [active] 484021011944 putative CoA binding site [chemical binding]; other site 484021011945 O-succinylbenzoate synthase; Provisional; Region: PRK05105 484021011946 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 484021011947 active site 484021011948 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 484021011949 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 484021011950 substrate binding site [chemical binding]; other site 484021011951 oxyanion hole (OAH) forming residues; other site 484021011952 trimer interface [polypeptide binding]; other site 484021011953 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 484021011954 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 484021011955 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 484021011956 dimer interface [polypeptide binding]; other site 484021011957 tetramer interface [polypeptide binding]; other site 484021011958 PYR/PP interface [polypeptide binding]; other site 484021011959 TPP binding site [chemical binding]; other site 484021011960 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 484021011961 TPP-binding site; other site 484021011962 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 484021011963 chorismate binding enzyme; Region: Chorismate_bind; cl10555 484021011964 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484021011965 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021011966 Coenzyme A binding pocket [chemical binding]; other site 484021011967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 484021011968 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 484021011969 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484021011970 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 484021011971 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484021011972 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 484021011973 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 484021011974 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484021011975 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 484021011976 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 484021011977 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 484021011978 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 484021011979 4Fe-4S binding domain; Region: Fer4; pfam00037 484021011980 4Fe-4S binding domain; Region: Fer4; pfam00037 484021011981 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 484021011982 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 484021011983 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021011984 catalytic loop [active] 484021011985 iron binding site [ion binding]; other site 484021011986 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 484021011987 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 484021011988 [4Fe-4S] binding site [ion binding]; other site 484021011989 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 484021011990 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 484021011991 SLBB domain; Region: SLBB; pfam10531 484021011992 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 484021011993 NADH dehydrogenase subunit E; Validated; Region: PRK07539 484021011994 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 484021011995 putative dimer interface [polypeptide binding]; other site 484021011996 [2Fe-2S] cluster binding site [ion binding]; other site 484021011997 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 484021011998 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 484021011999 NADH dehydrogenase subunit D; Validated; Region: PRK06075 484021012000 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 484021012001 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 484021012002 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 484021012003 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012004 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 484021012005 putative dimerization interface [polypeptide binding]; other site 484021012006 aminotransferase AlaT; Validated; Region: PRK09265 484021012007 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021012008 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021012009 homodimer interface [polypeptide binding]; other site 484021012010 catalytic residue [active] 484021012011 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021012012 Zn2+ binding site [ion binding]; other site 484021012013 Mg2+ binding site [ion binding]; other site 484021012014 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 484021012015 transmembrane helices; other site 484021012016 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 484021012017 TrkA-C domain; Region: TrkA_C; pfam02080 484021012018 TrkA-C domain; Region: TrkA_C; pfam02080 484021012019 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 484021012020 putative phosphatase; Provisional; Region: PRK11587 484021012021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021012022 motif II; other site 484021012023 hypothetical protein; Validated; Region: PRK05445 484021012024 hypothetical protein; Provisional; Region: PRK01816 484021012025 propionate/acetate kinase; Provisional; Region: PRK12379 484021012026 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 484021012027 phosphate acetyltransferase; Reviewed; Region: PRK05632 484021012028 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021012029 DRTGG domain; Region: DRTGG; pfam07085 484021012030 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 484021012031 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 484021012032 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 484021012033 nudix motif; other site 484021012034 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 484021012035 active site 484021012036 metal binding site [ion binding]; metal-binding site 484021012037 homotetramer interface [polypeptide binding]; other site 484021012038 glutathione S-transferase; Provisional; Region: PRK15113 484021012039 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 484021012040 C-terminal domain interface [polypeptide binding]; other site 484021012041 GSH binding site (G-site) [chemical binding]; other site 484021012042 dimer interface [polypeptide binding]; other site 484021012043 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 484021012044 N-terminal domain interface [polypeptide binding]; other site 484021012045 putative dimer interface [polypeptide binding]; other site 484021012046 putative substrate binding pocket (H-site) [chemical binding]; other site 484021012047 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 484021012048 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 484021012049 C-terminal domain interface [polypeptide binding]; other site 484021012050 GSH binding site (G-site) [chemical binding]; other site 484021012051 dimer interface [polypeptide binding]; other site 484021012052 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 484021012053 N-terminal domain interface [polypeptide binding]; other site 484021012054 putative dimer interface [polypeptide binding]; other site 484021012055 active site 484021012056 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 484021012057 homooctamer interface [polypeptide binding]; other site 484021012058 active site 484021012059 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 484021012060 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 484021012061 putative NAD(P) binding site [chemical binding]; other site 484021012062 putative active site [active] 484021012063 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484021012064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021012065 Coenzyme A binding pocket [chemical binding]; other site 484021012066 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 484021012067 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021012068 Walker A/P-loop; other site 484021012069 ATP binding site [chemical binding]; other site 484021012070 Q-loop/lid; other site 484021012071 ABC transporter signature motif; other site 484021012072 Walker B; other site 484021012073 D-loop; other site 484021012074 H-loop/switch region; other site 484021012075 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021012076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021012077 dimer interface [polypeptide binding]; other site 484021012078 conserved gate region; other site 484021012079 putative PBP binding loops; other site 484021012080 ABC-ATPase subunit interface; other site 484021012081 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484021012082 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021012083 dimer interface [polypeptide binding]; other site 484021012084 conserved gate region; other site 484021012085 putative PBP binding loops; other site 484021012086 ABC-ATPase subunit interface; other site 484021012087 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 484021012088 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021012089 substrate binding pocket [chemical binding]; other site 484021012090 membrane-bound complex binding site; other site 484021012091 hinge residues; other site 484021012092 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 484021012093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021012094 substrate binding pocket [chemical binding]; other site 484021012095 membrane-bound complex binding site; other site 484021012096 hinge residues; other site 484021012097 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 484021012098 Flavoprotein; Region: Flavoprotein; pfam02441 484021012099 amidophosphoribosyltransferase; Provisional; Region: PRK09246 484021012100 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 484021012101 active site 484021012102 tetramer interface [polypeptide binding]; other site 484021012103 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021012104 active site 484021012105 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 484021012106 colicin V production protein; Provisional; Region: PRK10845 484021012107 cell division protein DedD; Provisional; Region: PRK11633 484021012108 Sporulation related domain; Region: SPOR; pfam05036 484021012109 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 484021012110 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484021012111 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484021012112 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 484021012113 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 484021012114 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484021012115 hypothetical protein; Provisional; Region: PRK10847 484021012116 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 484021012117 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 484021012118 dimerization interface 3.5A [polypeptide binding]; other site 484021012119 active site 484021012120 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 484021012121 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484021012122 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 484021012123 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 484021012124 ligand binding site [chemical binding]; other site 484021012125 NAD binding site [chemical binding]; other site 484021012126 catalytic site [active] 484021012127 homodimer interface [polypeptide binding]; other site 484021012128 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 484021012129 putative transporter; Provisional; Region: PRK12382 484021012130 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 484021012131 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 484021012132 dimer interface [polypeptide binding]; other site 484021012133 active site 484021012134 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 484021012135 Uncharacterized conserved protein [Function unknown]; Region: COG4121 484021012136 YfcL protein; Region: YfcL; pfam08891 484021012137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 484021012138 hypothetical protein; Provisional; Region: PRK10621 484021012139 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484021012140 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 484021012141 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 484021012142 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 484021012143 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 484021012144 Tetramer interface [polypeptide binding]; other site 484021012145 active site 484021012146 FMN-binding site [chemical binding]; other site 484021012147 HemK family putative methylases; Region: hemK_fam; TIGR00536 484021012148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021012149 S-adenosylmethionine binding site [chemical binding]; other site 484021012150 hypothetical protein; Provisional; Region: PRK04946 484021012151 Smr domain; Region: Smr; pfam01713 484021012152 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484021012153 catalytic core [active] 484021012154 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 484021012155 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 484021012156 substrate binding site [chemical binding]; other site 484021012157 oxyanion hole (OAH) forming residues; other site 484021012158 trimer interface [polypeptide binding]; other site 484021012159 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 484021012160 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021012161 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 484021012162 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 484021012163 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021012164 dimer interface [polypeptide binding]; other site 484021012165 active site 484021012166 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 484021012167 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 484021012168 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 484021012169 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 484021012170 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 484021012171 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 484021012172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012173 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021012174 dimerization interface [polypeptide binding]; other site 484021012175 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 484021012176 nucleoside/Zn binding site; other site 484021012177 dimer interface [polypeptide binding]; other site 484021012178 catalytic motif [active] 484021012179 putative cyanate transporter; Provisional; Region: cynX; PRK09705 484021012180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012181 aminotransferase; Validated; Region: PRK08175 484021012182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021012183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021012184 homodimer interface [polypeptide binding]; other site 484021012185 catalytic residue [active] 484021012186 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 484021012187 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 484021012188 Histidine kinase; Region: His_kinase; pfam06580 484021012189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021012190 ATP binding site [chemical binding]; other site 484021012191 Mg2+ binding site [ion binding]; other site 484021012192 G-X-G motif; other site 484021012193 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 484021012194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021012195 active site 484021012196 phosphorylation site [posttranslational modification] 484021012197 intermolecular recognition site; other site 484021012198 dimerization interface [polypeptide binding]; other site 484021012199 LytTr DNA-binding domain; Region: LytTR; pfam04397 484021012200 glucokinase; Provisional; Region: glk; PRK00292 484021012201 glucokinase, proteobacterial type; Region: glk; TIGR00749 484021012202 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 484021012203 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 484021012204 Cl- selectivity filter; other site 484021012205 Cl- binding residues [ion binding]; other site 484021012206 pore gating glutamate residue; other site 484021012207 dimer interface [polypeptide binding]; other site 484021012208 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 484021012209 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 484021012210 dimer interface [polypeptide binding]; other site 484021012211 PYR/PP interface [polypeptide binding]; other site 484021012212 TPP binding site [chemical binding]; other site 484021012213 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021012214 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 484021012215 TPP-binding site [chemical binding]; other site 484021012216 dimer interface [polypeptide binding]; other site 484021012217 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021012218 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021012219 active site 484021012220 catalytic tetrad [active] 484021012221 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 484021012222 manganese transport protein MntH; Reviewed; Region: PRK00701 484021012223 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 484021012224 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 484021012225 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 484021012226 Nucleoside recognition; Region: Gate; pfam07670 484021012227 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 484021012228 MASE1; Region: MASE1; pfam05231 484021012229 diguanylate cyclase; Region: GGDEF; smart00267 484021012230 metal binding site [ion binding]; metal-binding site 484021012231 nucleotidyl binding site; other site 484021012232 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021012233 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 484021012234 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 484021012235 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 484021012236 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484021012237 active site 484021012238 HIGH motif; other site 484021012239 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484021012240 active site 484021012241 KMSKS motif; other site 484021012242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021012243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012244 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 484021012245 putative dimerization interface [polypeptide binding]; other site 484021012246 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 484021012247 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 484021012248 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 484021012249 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 484021012250 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 484021012251 nucleotide binding pocket [chemical binding]; other site 484021012252 K-X-D-G motif; other site 484021012253 catalytic site [active] 484021012254 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 484021012255 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 484021012256 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 484021012257 Dimer interface [polypeptide binding]; other site 484021012258 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 484021012259 cell division protein ZipA; Provisional; Region: PRK03427 484021012260 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 484021012261 FtsZ protein binding site [polypeptide binding]; other site 484021012262 putative sulfate transport protein CysZ; Validated; Region: PRK04949 484021012263 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484021012264 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 484021012265 dimer interface [polypeptide binding]; other site 484021012266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021012267 catalytic residue [active] 484021012268 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484021012269 dimerization domain swap beta strand [polypeptide binding]; other site 484021012270 regulatory protein interface [polypeptide binding]; other site 484021012271 active site 484021012272 regulatory phosphorylation site [posttranslational modification]; other site 484021012273 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 484021012274 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 484021012275 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484021012276 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 484021012277 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 484021012278 HPr interaction site; other site 484021012279 glycerol kinase (GK) interaction site [polypeptide binding]; other site 484021012280 active site 484021012281 phosphorylation site [posttranslational modification] 484021012282 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 484021012283 dimer interface [polypeptide binding]; other site 484021012284 pyridoxamine kinase; Validated; Region: PRK05756 484021012285 pyridoxal binding site [chemical binding]; other site 484021012286 ATP binding site [chemical binding]; other site 484021012287 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 484021012288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021012289 DNA-binding site [nucleotide binding]; DNA binding site 484021012290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021012291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021012292 homodimer interface [polypeptide binding]; other site 484021012293 catalytic residue [active] 484021012294 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 484021012295 cysteine synthase B; Region: cysM; TIGR01138 484021012296 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 484021012297 dimer interface [polypeptide binding]; other site 484021012298 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021012299 catalytic residue [active] 484021012300 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 484021012301 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 484021012302 Walker A/P-loop; other site 484021012303 ATP binding site [chemical binding]; other site 484021012304 Q-loop/lid; other site 484021012305 ABC transporter signature motif; other site 484021012306 Walker B; other site 484021012307 D-loop; other site 484021012308 H-loop/switch region; other site 484021012309 TOBE-like domain; Region: TOBE_3; pfam12857 484021012310 sulfate transport protein; Provisional; Region: cysT; CHL00187 484021012311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021012312 dimer interface [polypeptide binding]; other site 484021012313 conserved gate region; other site 484021012314 putative PBP binding loops; other site 484021012315 ABC-ATPase subunit interface; other site 484021012316 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 484021012317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021012318 dimer interface [polypeptide binding]; other site 484021012319 conserved gate region; other site 484021012320 putative PBP binding loops; other site 484021012321 ABC-ATPase subunit interface; other site 484021012322 thiosulfate transporter subunit; Provisional; Region: PRK10852 484021012323 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 484021012324 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 484021012325 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 484021012326 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 484021012327 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 484021012328 putative acetyltransferase; Provisional; Region: PRK03624 484021012329 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021012330 Coenzyme A binding pocket [chemical binding]; other site 484021012331 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 484021012332 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 484021012333 active site 484021012334 metal binding site [ion binding]; metal-binding site 484021012335 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 484021012336 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 484021012337 transcriptional regulator EutR; Provisional; Region: PRK10130 484021012338 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021012339 carboxysome structural protein EutK; Provisional; Region: PRK15466 484021012340 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 484021012341 Hexamer interface [polypeptide binding]; other site 484021012342 Hexagonal pore residue; other site 484021012343 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 484021012344 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 484021012345 putative hexamer interface [polypeptide binding]; other site 484021012346 putative hexagonal pore; other site 484021012347 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 484021012348 putative hexamer interface [polypeptide binding]; other site 484021012349 putative hexagonal pore; other site 484021012350 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 484021012351 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 484021012352 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 484021012353 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 484021012354 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 484021012355 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 484021012356 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 484021012357 active site 484021012358 metal binding site [ion binding]; metal-binding site 484021012359 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 484021012360 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021012361 nucleotide binding site [chemical binding]; other site 484021012362 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 484021012363 NAD(P) binding site [chemical binding]; other site 484021012364 catalytic residues [active] 484021012365 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 484021012366 Hexamer/Pentamer interface [polypeptide binding]; other site 484021012367 central pore; other site 484021012368 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 484021012369 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 484021012370 Hexamer interface [polypeptide binding]; other site 484021012371 Hexagonal pore residue; other site 484021012372 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 484021012373 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 484021012374 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 484021012375 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 484021012376 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 484021012377 G1 box; other site 484021012378 GTP/Mg2+ binding site [chemical binding]; other site 484021012379 G2 box; other site 484021012380 Switch I region; other site 484021012381 G3 box; other site 484021012382 Switch II region; other site 484021012383 G4 box; other site 484021012384 G5 box; other site 484021012385 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 484021012386 putative hexamer interface [polypeptide binding]; other site 484021012387 putative hexagonal pore; other site 484021012388 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 484021012389 Malic enzyme, N-terminal domain; Region: malic; pfam00390 484021012390 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 484021012391 putative NAD(P) binding site [chemical binding]; other site 484021012392 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 484021012393 transaldolase-like protein; Provisional; Region: PTZ00411 484021012394 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 484021012395 active site 484021012396 dimer interface [polypeptide binding]; other site 484021012397 catalytic residue [active] 484021012398 transketolase; Reviewed; Region: PRK12753 484021012399 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484021012400 TPP-binding site [chemical binding]; other site 484021012401 dimer interface [polypeptide binding]; other site 484021012402 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484021012403 PYR/PP interface [polypeptide binding]; other site 484021012404 dimer interface [polypeptide binding]; other site 484021012405 TPP binding site [chemical binding]; other site 484021012406 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021012407 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 484021012408 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 484021012409 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484021012410 dimer interface [polypeptide binding]; other site 484021012411 ADP-ribose binding site [chemical binding]; other site 484021012412 active site 484021012413 nudix motif; other site 484021012414 metal binding site [ion binding]; metal-binding site 484021012415 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 484021012416 4Fe-4S binding domain; Region: Fer4; pfam00037 484021012417 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021012418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021012419 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 484021012420 Protein export membrane protein; Region: SecD_SecF; cl14618 484021012421 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 484021012422 ArsC family; Region: ArsC; pfam03960 484021012423 putative catalytic residues [active] 484021012424 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 484021012425 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 484021012426 metal binding site [ion binding]; metal-binding site 484021012427 dimer interface [polypeptide binding]; other site 484021012428 hypothetical protein; Provisional; Region: PRK13664 484021012429 putative hydrolase; Provisional; Region: PRK11460 484021012430 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 484021012431 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 484021012432 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 484021012433 Helicase; Region: Helicase_RecD; pfam05127 484021012434 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 484021012435 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 484021012436 Predicted metalloprotease [General function prediction only]; Region: COG2321 484021012437 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 484021012438 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 484021012439 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 484021012440 ATP binding site [chemical binding]; other site 484021012441 active site 484021012442 substrate binding site [chemical binding]; other site 484021012443 lipoprotein; Provisional; Region: PRK11679 484021012444 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 484021012445 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 484021012446 dihydrodipicolinate synthase; Region: dapA; TIGR00674 484021012447 dimer interface [polypeptide binding]; other site 484021012448 active site 484021012449 catalytic residue [active] 484021012450 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 484021012451 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 484021012452 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 484021012453 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 484021012454 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 484021012455 catalytic triad [active] 484021012456 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 484021012457 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484021012458 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 484021012459 Peptidase family M48; Region: Peptidase_M48; cl12018 484021012460 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 484021012461 ArsC family; Region: ArsC; pfam03960 484021012462 catalytic residues [active] 484021012463 hypothetical protein; Provisional; Region: PRK09956 484021012464 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 484021012465 DNA replication initiation factor; Provisional; Region: PRK08084 484021012466 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 484021012467 uracil transporter; Provisional; Region: PRK10720 484021012468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021012469 active site 484021012470 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 484021012471 beta-galactosidase; Region: BGL; TIGR03356 484021012472 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484021012473 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021012474 nucleotide binding site [chemical binding]; other site 484021012475 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 484021012476 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 484021012477 dimerization interface [polypeptide binding]; other site 484021012478 putative ATP binding site [chemical binding]; other site 484021012479 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 484021012480 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 484021012481 active site 484021012482 substrate binding site [chemical binding]; other site 484021012483 cosubstrate binding site; other site 484021012484 catalytic site [active] 484021012485 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 484021012486 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 484021012487 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 484021012488 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 484021012489 domain interface [polypeptide binding]; other site 484021012490 active site 484021012491 catalytic site [active] 484021012492 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 484021012493 domain interface [polypeptide binding]; other site 484021012494 active site 484021012495 catalytic site [active] 484021012496 exopolyphosphatase; Provisional; Region: PRK10854 484021012497 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 484021012498 MASE1; Region: MASE1; pfam05231 484021012499 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 484021012500 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 484021012501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021012502 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 484021012503 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021012504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021012506 dimerization interface [polypeptide binding]; other site 484021012507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021012508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012509 putative substrate translocation pore; other site 484021012510 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 484021012511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021012512 FeS/SAM binding site; other site 484021012513 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 484021012514 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 484021012515 Sulfatase; Region: Sulfatase; cl17466 484021012516 GMP synthase; Reviewed; Region: guaA; PRK00074 484021012517 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 484021012518 AMP/PPi binding site [chemical binding]; other site 484021012519 candidate oxyanion hole; other site 484021012520 catalytic triad [active] 484021012521 potential glutamine specificity residues [chemical binding]; other site 484021012522 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 484021012523 ATP Binding subdomain [chemical binding]; other site 484021012524 Ligand Binding sites [chemical binding]; other site 484021012525 Dimerization subdomain; other site 484021012526 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 484021012527 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484021012528 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 484021012529 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 484021012530 active site 484021012531 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 484021012532 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 484021012533 generic binding surface II; other site 484021012534 generic binding surface I; other site 484021012535 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 484021012536 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 484021012537 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021012538 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021012539 GTP-binding protein Der; Reviewed; Region: PRK00093 484021012540 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 484021012541 G1 box; other site 484021012542 GTP/Mg2+ binding site [chemical binding]; other site 484021012543 Switch I region; other site 484021012544 G2 box; other site 484021012545 Switch II region; other site 484021012546 G3 box; other site 484021012547 G4 box; other site 484021012548 G5 box; other site 484021012549 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 484021012550 G1 box; other site 484021012551 GTP/Mg2+ binding site [chemical binding]; other site 484021012552 Switch I region; other site 484021012553 G2 box; other site 484021012554 G3 box; other site 484021012555 Switch II region; other site 484021012556 G4 box; other site 484021012557 G5 box; other site 484021012558 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 484021012559 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 484021012560 Trp docking motif [polypeptide binding]; other site 484021012561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 484021012562 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 484021012563 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 484021012564 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 484021012565 dimer interface [polypeptide binding]; other site 484021012566 motif 1; other site 484021012567 active site 484021012568 motif 2; other site 484021012569 motif 3; other site 484021012570 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 484021012571 anticodon binding site; other site 484021012572 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 484021012573 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 484021012574 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 484021012575 cytoskeletal protein RodZ; Provisional; Region: PRK10856 484021012576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021012577 non-specific DNA binding site [nucleotide binding]; other site 484021012578 salt bridge; other site 484021012579 sequence-specific DNA binding site [nucleotide binding]; other site 484021012580 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 484021012581 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 484021012582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021012583 FeS/SAM binding site; other site 484021012584 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 484021012585 active site 484021012586 multimer interface [polypeptide binding]; other site 484021012587 penicillin-binding protein 1C; Provisional; Region: PRK11240 484021012588 Transglycosylase; Region: Transgly; pfam00912 484021012589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 484021012590 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 484021012591 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 484021012592 MG2 domain; Region: A2M_N; pfam01835 484021012593 Alpha-2-macroglobulin family; Region: A2M; pfam00207 484021012594 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 484021012595 surface patch; other site 484021012596 thioester region; other site 484021012597 specificity defining residues; other site 484021012598 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 484021012599 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 484021012600 active site residue [active] 484021012601 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 484021012602 active site residue [active] 484021012603 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 484021012604 aminopeptidase B; Provisional; Region: PRK05015 484021012605 Peptidase; Region: DUF3663; pfam12404 484021012606 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 484021012607 interface (dimer of trimers) [polypeptide binding]; other site 484021012608 Substrate-binding/catalytic site; other site 484021012609 Zn-binding sites [ion binding]; other site 484021012610 hypothetical protein; Provisional; Region: PRK10721 484021012611 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 484021012612 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 484021012613 catalytic loop [active] 484021012614 iron binding site [ion binding]; other site 484021012615 chaperone protein HscA; Provisional; Region: hscA; PRK05183 484021012616 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 484021012617 nucleotide binding site [chemical binding]; other site 484021012618 putative NEF/HSP70 interaction site [polypeptide binding]; other site 484021012619 SBD interface [polypeptide binding]; other site 484021012620 co-chaperone HscB; Provisional; Region: hscB; PRK05014 484021012621 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484021012622 HSP70 interaction site [polypeptide binding]; other site 484021012623 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 484021012624 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 484021012625 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 484021012626 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 484021012627 trimerization site [polypeptide binding]; other site 484021012628 active site 484021012629 cysteine desulfurase; Provisional; Region: PRK14012 484021012630 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 484021012631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021012632 catalytic residue [active] 484021012633 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 484021012634 Rrf2 family protein; Region: rrf2_super; TIGR00738 484021012635 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 484021012636 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 484021012637 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 484021012638 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 484021012639 active site 484021012640 dimerization interface [polypeptide binding]; other site 484021012641 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 484021012642 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 484021012643 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 484021012644 PRD domain; Region: PRD; pfam00874 484021012645 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 484021012646 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012647 putative substrate translocation pore; other site 484021012648 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 484021012649 active site 484021012650 catalytic residues [active] 484021012651 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 484021012652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012653 putative substrate translocation pore; other site 484021012654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012655 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 484021012656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021012657 binding surface 484021012658 TPR motif; other site 484021012659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021012660 binding surface 484021012661 TPR motif; other site 484021012662 TPR repeat; Region: TPR_11; pfam13414 484021012663 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021012664 binding surface 484021012665 TPR motif; other site 484021012666 potential frameshift: common BLAST hit: gi|152971405|ref|YP_001336514.1| putative NAGC-like transcriptional regulator 484021012667 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 484021012668 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484021012669 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484021012670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484021012671 Predicted membrane protein [Function unknown]; Region: COG2259 484021012672 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 484021012673 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 484021012674 dimer interface [polypeptide binding]; other site 484021012675 active site 484021012676 glycine-pyridoxal phosphate binding site [chemical binding]; other site 484021012677 folate binding site [chemical binding]; other site 484021012678 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 484021012679 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 484021012680 heme-binding site [chemical binding]; other site 484021012681 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 484021012682 FAD binding pocket [chemical binding]; other site 484021012683 FAD binding motif [chemical binding]; other site 484021012684 phosphate binding motif [ion binding]; other site 484021012685 beta-alpha-beta structure motif; other site 484021012686 NAD binding pocket [chemical binding]; other site 484021012687 Heme binding pocket [chemical binding]; other site 484021012688 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 484021012689 Nitrogen regulatory protein P-II; Region: P-II; smart00938 484021012690 response regulator GlrR; Provisional; Region: PRK15115 484021012691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021012692 active site 484021012693 phosphorylation site [posttranslational modification] 484021012694 intermolecular recognition site; other site 484021012695 dimerization interface [polypeptide binding]; other site 484021012696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021012697 Walker A motif; other site 484021012698 ATP binding site [chemical binding]; other site 484021012699 Walker B motif; other site 484021012700 arginine finger; other site 484021012701 hypothetical protein; Provisional; Region: PRK10722 484021012702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484021012703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021012704 dimer interface [polypeptide binding]; other site 484021012705 phosphorylation site [posttranslational modification] 484021012706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021012707 ATP binding site [chemical binding]; other site 484021012708 Mg2+ binding site [ion binding]; other site 484021012709 G-X-G motif; other site 484021012710 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 484021012711 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 484021012712 dimerization interface [polypeptide binding]; other site 484021012713 ATP binding site [chemical binding]; other site 484021012714 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 484021012715 dimerization interface [polypeptide binding]; other site 484021012716 ATP binding site [chemical binding]; other site 484021012717 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 484021012718 putative active site [active] 484021012719 catalytic triad [active] 484021012720 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 484021012721 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021012722 substrate binding pocket [chemical binding]; other site 484021012723 membrane-bound complex binding site; other site 484021012724 hinge residues; other site 484021012725 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021012726 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021012727 catalytic residue [active] 484021012728 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 484021012729 nucleoside/Zn binding site; other site 484021012730 dimer interface [polypeptide binding]; other site 484021012731 catalytic motif [active] 484021012732 hypothetical protein; Provisional; Region: PRK11590 484021012733 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 484021012734 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021012735 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 484021012736 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021012737 putative active site [active] 484021012738 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 484021012739 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 484021012740 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 484021012741 active site 484021012742 hydrophilic channel; other site 484021012743 dimerization interface [polypeptide binding]; other site 484021012744 catalytic residues [active] 484021012745 active site lid [active] 484021012746 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 484021012747 Recombination protein O N terminal; Region: RecO_N; pfam11967 484021012748 Recombination protein O C terminal; Region: RecO_C; pfam02565 484021012749 GTPase Era; Reviewed; Region: era; PRK00089 484021012750 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 484021012751 G1 box; other site 484021012752 GTP/Mg2+ binding site [chemical binding]; other site 484021012753 Switch I region; other site 484021012754 G2 box; other site 484021012755 Switch II region; other site 484021012756 G3 box; other site 484021012757 G4 box; other site 484021012758 G5 box; other site 484021012759 KH domain; Region: KH_2; pfam07650 484021012760 ribonuclease III; Reviewed; Region: rnc; PRK00102 484021012761 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 484021012762 dimerization interface [polypeptide binding]; other site 484021012763 active site 484021012764 metal binding site [ion binding]; metal-binding site 484021012765 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 484021012766 dsRNA binding site [nucleotide binding]; other site 484021012767 signal peptidase I; Provisional; Region: PRK10861 484021012768 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484021012769 Catalytic site [active] 484021012770 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484021012771 GTP-binding protein LepA; Provisional; Region: PRK05433 484021012772 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 484021012773 G1 box; other site 484021012774 putative GEF interaction site [polypeptide binding]; other site 484021012775 GTP/Mg2+ binding site [chemical binding]; other site 484021012776 Switch I region; other site 484021012777 G2 box; other site 484021012778 G3 box; other site 484021012779 Switch II region; other site 484021012780 G4 box; other site 484021012781 G5 box; other site 484021012782 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 484021012783 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 484021012784 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 484021012785 SoxR reducing system protein RseC; Provisional; Region: PRK10862 484021012786 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 484021012787 anti-sigma E factor; Provisional; Region: rseB; PRK09455 484021012788 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 484021012789 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 484021012790 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 484021012791 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 484021012792 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484021012793 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484021012794 DNA binding residues [nucleotide binding] 484021012795 L-aspartate oxidase; Provisional; Region: PRK09077 484021012796 L-aspartate oxidase; Provisional; Region: PRK06175 484021012797 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484021012798 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 484021012799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484021012800 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 484021012801 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484021012802 ATP binding site [chemical binding]; other site 484021012803 Mg++ binding site [ion binding]; other site 484021012804 motif III; other site 484021012805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021012806 nucleotide binding region [chemical binding]; other site 484021012807 ATP-binding site [chemical binding]; other site 484021012808 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 484021012809 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 484021012810 ligand binding site [chemical binding]; other site 484021012811 active site 484021012812 UGI interface [polypeptide binding]; other site 484021012813 catalytic site [active] 484021012814 putative methyltransferase; Provisional; Region: PRK10864 484021012815 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 484021012816 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 484021012817 thioredoxin 2; Provisional; Region: PRK10996 484021012818 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484021012819 catalytic residues [active] 484021012820 Uncharacterized conserved protein [Function unknown]; Region: COG3148 484021012821 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 484021012822 CoA binding domain; Region: CoA_binding_2; pfam13380 484021012823 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 484021012824 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 484021012825 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484021012826 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484021012827 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 484021012828 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 484021012829 domain interface [polypeptide binding]; other site 484021012830 putative active site [active] 484021012831 catalytic site [active] 484021012832 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 484021012833 domain interface [polypeptide binding]; other site 484021012834 putative active site [active] 484021012835 catalytic site [active] 484021012836 lipoprotein; Provisional; Region: PRK10759 484021012837 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 484021012838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012839 putative substrate translocation pore; other site 484021012840 protein disaggregation chaperone; Provisional; Region: PRK10865 484021012841 Clp amino terminal domain; Region: Clp_N; pfam02861 484021012842 Clp amino terminal domain; Region: Clp_N; pfam02861 484021012843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021012844 Walker A motif; other site 484021012845 ATP binding site [chemical binding]; other site 484021012846 Walker B motif; other site 484021012847 arginine finger; other site 484021012848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021012849 Walker A motif; other site 484021012850 ATP binding site [chemical binding]; other site 484021012851 Walker B motif; other site 484021012852 arginine finger; other site 484021012853 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484021012854 hypothetical protein; Provisional; Region: PRK10723 484021012855 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 484021012856 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 484021012857 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021012858 RNA binding surface [nucleotide binding]; other site 484021012859 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484021012860 active site 484021012861 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 484021012862 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 484021012863 30S subunit binding site; other site 484021012864 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 484021012865 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 484021012866 Prephenate dehydratase; Region: PDT; pfam00800 484021012867 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 484021012868 putative L-Phe binding site [chemical binding]; other site 484021012869 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 484021012870 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 484021012871 Chorismate mutase type II; Region: CM_2; cl00693 484021012872 prephenate dehydrogenase; Validated; Region: PRK08507 484021012873 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 484021012874 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484021012875 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 484021012876 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 484021012877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021012878 metal binding site [ion binding]; metal-binding site 484021012879 active site 484021012880 I-site; other site 484021012881 putative outer membrane lipoprotein; Provisional; Region: PRK09967 484021012882 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484021012883 ligand binding site [chemical binding]; other site 484021012884 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 484021012885 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 484021012886 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 484021012887 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 484021012888 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 484021012889 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 484021012890 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 484021012891 RimM N-terminal domain; Region: RimM; pfam01782 484021012892 PRC-barrel domain; Region: PRC; pfam05239 484021012893 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 484021012894 signal recognition particle protein; Provisional; Region: PRK10867 484021012895 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 484021012896 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484021012897 P loop; other site 484021012898 GTP binding site [chemical binding]; other site 484021012899 Signal peptide binding domain; Region: SRP_SPB; pfam02978 484021012900 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 484021012901 Domain of unknown function DUF21; Region: DUF21; pfam01595 484021012902 hypothetical protein; Provisional; Region: PRK11573 484021012903 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484021012904 Transporter associated domain; Region: CorC_HlyC; smart01091 484021012905 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 484021012906 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 484021012907 dimer interface [polypeptide binding]; other site 484021012908 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 484021012909 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 484021012910 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 484021012911 recombination and repair protein; Provisional; Region: PRK10869 484021012912 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 484021012913 Walker A/P-loop; other site 484021012914 ATP binding site [chemical binding]; other site 484021012915 Q-loop/lid; other site 484021012916 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 484021012917 ABC transporter signature motif; other site 484021012918 Walker B; other site 484021012919 D-loop; other site 484021012920 H-loop/switch region; other site 484021012921 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 484021012922 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 484021012923 hypothetical protein; Validated; Region: PRK01777 484021012924 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 484021012925 putative coenzyme Q binding site [chemical binding]; other site 484021012926 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 484021012927 SmpB-tmRNA interface; other site 484021012928 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021012929 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012930 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021012931 putative effector binding pocket; other site 484021012932 putative dimerization interface [polypeptide binding]; other site 484021012933 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 484021012934 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 484021012935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021012936 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 484021012937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021012938 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021012939 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 484021012940 Predicted transcriptional regulator [Transcription]; Region: COG1959 484021012941 Transcriptional regulator; Region: Rrf2; pfam02082 484021012942 Transcriptional regulator; Region: Rrf2; cl17282 484021012943 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 484021012944 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 484021012945 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484021012946 pyranose oxidase; Region: pyranose_ox; TIGR02462 484021012947 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 484021012948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012949 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021012950 putative substrate translocation pore; other site 484021012951 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 484021012952 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 484021012953 Predicted flavoprotein [General function prediction only]; Region: COG0431 484021012954 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484021012955 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 484021012956 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 484021012957 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 484021012958 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 484021012959 active site 484021012960 oxyanion hole [active] 484021012961 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 484021012962 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 484021012963 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 484021012964 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021012965 putative substrate translocation pore; other site 484021012966 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021012967 Putative cyclase; Region: Cyclase; pfam04199 484021012968 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 484021012969 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 484021012970 iron-sulfur cluster [ion binding]; other site 484021012971 [2Fe-2S] cluster binding site [ion binding]; other site 484021012972 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 484021012973 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 484021012974 putative active site [active] 484021012975 putative metal binding site [ion binding]; other site 484021012976 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484021012977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021012978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012979 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 484021012980 putative substrate binding pocket [chemical binding]; other site 484021012981 putative dimerization interface [polypeptide binding]; other site 484021012982 hypothetical protein; Provisional; Region: PRK06847 484021012983 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 484021012984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021012985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021012986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021012987 dimerization interface [polypeptide binding]; other site 484021012988 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 484021012989 agmatinase; Region: agmatinase; TIGR01230 484021012990 oligomer interface [polypeptide binding]; other site 484021012991 putative active site [active] 484021012992 Mn binding site [ion binding]; other site 484021012993 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 484021012994 oxidase reductase; Provisional; Region: PTZ00273 484021012995 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 484021012996 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 484021012997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021012998 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021012999 substrate binding pocket [chemical binding]; other site 484021013000 membrane-bound complex binding site; other site 484021013001 hinge residues; other site 484021013002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021013003 dimer interface [polypeptide binding]; other site 484021013004 conserved gate region; other site 484021013005 ABC-ATPase subunit interface; other site 484021013006 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021013007 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484021013008 Walker A/P-loop; other site 484021013009 ATP binding site [chemical binding]; other site 484021013010 Q-loop/lid; other site 484021013011 ABC transporter signature motif; other site 484021013012 Walker B; other site 484021013013 D-loop; other site 484021013014 H-loop/switch region; other site 484021013015 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 484021013016 intersubunit interface [polypeptide binding]; other site 484021013017 active site 484021013018 Zn2+ binding site [ion binding]; other site 484021013019 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 484021013020 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 484021013021 putative ligand binding site [chemical binding]; other site 484021013022 NAD binding site [chemical binding]; other site 484021013023 dimerization interface [polypeptide binding]; other site 484021013024 catalytic site [active] 484021013025 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 484021013026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021013027 NAD(P) binding site [chemical binding]; other site 484021013028 active site 484021013029 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021013030 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021013031 substrate binding pocket [chemical binding]; other site 484021013032 membrane-bound complex binding site; other site 484021013033 hinge residues; other site 484021013034 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484021013035 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021013036 DNA binding residues [nucleotide binding] 484021013037 dimerization interface [polypeptide binding]; other site 484021013038 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021013039 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021013040 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021013041 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021013042 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021013043 PapC N-terminal domain; Region: PapC_N; pfam13954 484021013044 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021013045 PapC C-terminal domain; Region: PapC_C; pfam13953 484021013046 Fimbrial protein; Region: Fimbrial; pfam00419 484021013047 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021013048 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021013049 PapC N-terminal domain; Region: PapC_N; pfam13954 484021013050 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021013051 PapC C-terminal domain; Region: PapC_C; pfam13953 484021013052 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021013053 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021013054 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021013055 Fimbrial protein; Region: Fimbrial; cl01416 484021013056 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 484021013057 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 484021013058 NAD(P) binding site [chemical binding]; other site 484021013059 catalytic residues [active] 484021013060 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 484021013061 GAF domain; Region: GAF; pfam01590 484021013062 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021013063 Walker A motif; other site 484021013064 ATP binding site [chemical binding]; other site 484021013065 Walker B motif; other site 484021013066 arginine finger; other site 484021013067 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021013068 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021013069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021013070 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 484021013071 putative effector binding pocket; other site 484021013072 putative dimerization interface [polypeptide binding]; other site 484021013073 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 484021013074 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021013075 dimerization interface [polypeptide binding]; other site 484021013076 putative DNA binding site [nucleotide binding]; other site 484021013077 putative Zn2+ binding site [ion binding]; other site 484021013078 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 484021013079 active site residue [active] 484021013080 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 484021013081 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 484021013082 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 484021013083 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 484021013084 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 484021013085 hypothetical protein; Provisional; Region: PRK10556 484021013086 hypothetical protein; Provisional; Region: PRK10132 484021013087 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021013088 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021013089 DNA-binding site [nucleotide binding]; DNA binding site 484021013090 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021013091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021013092 homodimer interface [polypeptide binding]; other site 484021013093 catalytic residue [active] 484021013094 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 484021013095 Uncharacterized conserved protein [Function unknown]; Region: COG2128 484021013096 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 484021013097 catalytic residues [active] 484021013098 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 484021013099 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 484021013100 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 484021013101 Class I ribonucleotide reductase; Region: RNR_I; cd01679 484021013102 active site 484021013103 dimer interface [polypeptide binding]; other site 484021013104 catalytic residues [active] 484021013105 effector binding site; other site 484021013106 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 484021013107 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 484021013108 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 484021013109 dimer interface [polypeptide binding]; other site 484021013110 putative radical transfer pathway; other site 484021013111 diiron center [ion binding]; other site 484021013112 tyrosyl radical; other site 484021013113 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 484021013114 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 484021013115 Walker A/P-loop; other site 484021013116 ATP binding site [chemical binding]; other site 484021013117 Q-loop/lid; other site 484021013118 ABC transporter signature motif; other site 484021013119 Walker B; other site 484021013120 D-loop; other site 484021013121 H-loop/switch region; other site 484021013122 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 484021013123 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 484021013124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021013125 dimer interface [polypeptide binding]; other site 484021013126 conserved gate region; other site 484021013127 putative PBP binding loops; other site 484021013128 ABC-ATPase subunit interface; other site 484021013129 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 484021013130 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 484021013131 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 484021013132 putative L-valine exporter; Provisional; Region: PRK10408 484021013133 transcriptional repressor MprA; Provisional; Region: PRK10870 484021013134 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021013135 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 484021013136 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021013137 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021013138 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484021013139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013140 putative substrate translocation pore; other site 484021013141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013142 2-isopropylmalate synthase; Validated; Region: PRK03739 484021013143 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 484021013144 active site 484021013145 catalytic residues [active] 484021013146 metal binding site [ion binding]; metal-binding site 484021013147 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 484021013148 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484021013149 Helix-turn-helix domain; Region: HTH_18; pfam12833 484021013150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021013151 S-ribosylhomocysteinase; Provisional; Region: PRK02260 484021013152 glutamate--cysteine ligase; Provisional; Region: PRK02107 484021013153 Predicted membrane protein [Function unknown]; Region: COG1238 484021013154 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 484021013155 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021013156 motif II; other site 484021013157 BON domain; Region: BON; pfam04972 484021013158 carbon storage regulator; Provisional; Region: PRK01712 484021013159 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 484021013160 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 484021013161 motif 1; other site 484021013162 active site 484021013163 motif 2; other site 484021013164 motif 3; other site 484021013165 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 484021013166 DHHA1 domain; Region: DHHA1; pfam02272 484021013167 recombination regulator RecX; Reviewed; Region: recX; PRK00117 484021013168 recombinase A; Provisional; Region: recA; PRK09354 484021013169 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 484021013170 hexamer interface [polypeptide binding]; other site 484021013171 Walker A motif; other site 484021013172 ATP binding site [chemical binding]; other site 484021013173 Walker B motif; other site 484021013174 hypothetical protein; Validated; Region: PRK03661 484021013175 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 484021013176 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 484021013177 metal binding site [ion binding]; metal-binding site 484021013178 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 484021013179 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021013180 ABC-ATPase subunit interface; other site 484021013181 dimer interface [polypeptide binding]; other site 484021013182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484021013183 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 484021013184 Transglycosylase SLT domain; Region: SLT_2; pfam13406 484021013185 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021013186 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021013187 catalytic residue [active] 484021013188 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 484021013189 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 484021013190 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 484021013191 Nucleoside recognition; Region: Gate; pfam07670 484021013192 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 484021013193 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 484021013194 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 484021013195 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 484021013196 putative NAD(P) binding site [chemical binding]; other site 484021013197 active site 484021013198 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 484021013199 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 484021013200 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 484021013201 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021013202 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 484021013203 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 484021013204 putative active site [active] 484021013205 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 484021013206 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 484021013207 GAF domain; Region: GAF; pfam01590 484021013208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021013209 Walker A motif; other site 484021013210 ATP binding site [chemical binding]; other site 484021013211 Walker B motif; other site 484021013212 arginine finger; other site 484021013213 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 484021013214 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484021013215 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 484021013216 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 484021013217 iron binding site [ion binding]; other site 484021013218 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 484021013219 UAF complex subunit Rrn10; Region: UAF_Rrn10; pfam05234 484021013220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021013221 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021013222 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 484021013223 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 484021013224 Acylphosphatase; Region: Acylphosphatase; pfam00708 484021013225 HypF finger; Region: zf-HYPF; pfam07503 484021013226 HypF finger; Region: zf-HYPF; pfam07503 484021013227 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 484021013228 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 484021013229 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 484021013230 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021013231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021013232 DNA binding site [nucleotide binding] 484021013233 domain linker motif; other site 484021013234 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 484021013235 dimerization interface (closed form) [polypeptide binding]; other site 484021013236 ligand binding site [chemical binding]; other site 484021013237 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 484021013238 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021013239 active site turn [active] 484021013240 phosphorylation site [posttranslational modification] 484021013241 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 484021013242 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 484021013243 beta-galactosidase; Region: BGL; TIGR03356 484021013244 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 484021013245 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 484021013246 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 484021013247 nickel binding site [ion binding]; other site 484021013248 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 484021013249 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 484021013250 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 484021013251 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 484021013252 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 484021013253 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 484021013254 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 484021013255 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 484021013256 NADH dehydrogenase; Region: NADHdh; cl00469 484021013257 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 484021013258 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 484021013259 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 484021013260 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 484021013261 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 484021013262 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 484021013263 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 484021013264 hydrogenase assembly chaperone; Provisional; Region: PRK10409 484021013265 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 484021013266 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 484021013267 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 484021013268 dimerization interface [polypeptide binding]; other site 484021013269 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 484021013270 ATP binding site [chemical binding]; other site 484021013271 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 484021013272 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 484021013273 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 484021013274 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021013275 Walker A motif; other site 484021013276 ATP binding site [chemical binding]; other site 484021013277 Walker B motif; other site 484021013278 arginine finger; other site 484021013279 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 484021013280 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 484021013281 beta-galactosidase; Region: BGL; TIGR03356 484021013282 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 484021013283 Interdomain contacts; other site 484021013284 Cytokine receptor motif; other site 484021013285 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 484021013286 putative metal binding site [ion binding]; other site 484021013287 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 484021013288 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484021013289 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021013290 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484021013291 active site 484021013292 P-loop; other site 484021013293 phosphorylation site [posttranslational modification] 484021013294 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484021013295 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021013296 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 484021013297 methionine cluster; other site 484021013298 active site 484021013299 phosphorylation site [posttranslational modification] 484021013300 metal binding site [ion binding]; metal-binding site 484021013301 fructokinase; Reviewed; Region: PRK09557 484021013302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484021013303 nucleotide binding site [chemical binding]; other site 484021013304 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021013305 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021013306 DNA binding site [nucleotide binding] 484021013307 domain linker motif; other site 484021013308 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484021013309 ligand binding site [chemical binding]; other site 484021013310 dimerization interface [polypeptide binding]; other site 484021013311 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 484021013312 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 484021013313 metal binding site [ion binding]; metal-binding site 484021013314 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 484021013315 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 484021013316 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 484021013317 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021013318 ABC-ATPase subunit interface; other site 484021013319 dimer interface [polypeptide binding]; other site 484021013320 putative PBP binding regions; other site 484021013321 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 484021013322 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021013323 ABC-ATPase subunit interface; other site 484021013324 dimer interface [polypeptide binding]; other site 484021013325 putative PBP binding regions; other site 484021013326 Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119 484021013327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021013328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021013329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021013330 dimerization interface [polypeptide binding]; other site 484021013331 Membrane transport protein; Region: Mem_trans; cl09117 484021013332 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 484021013333 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021013334 PYR/PP interface [polypeptide binding]; other site 484021013335 dimer interface [polypeptide binding]; other site 484021013336 TPP binding site [chemical binding]; other site 484021013337 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 484021013338 TPP-binding site [chemical binding]; other site 484021013339 Rdx family; Region: Rdx; cl01407 484021013340 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 484021013341 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 484021013342 N-terminal plug; other site 484021013343 ligand-binding site [chemical binding]; other site 484021013344 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 484021013345 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 484021013346 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 484021013347 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 484021013348 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 484021013349 putative hemin binding site; other site 484021013350 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 484021013351 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484021013352 ABC-ATPase subunit interface; other site 484021013353 dimer interface [polypeptide binding]; other site 484021013354 putative PBP binding regions; other site 484021013355 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 484021013356 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 484021013357 Walker A/P-loop; other site 484021013358 ATP binding site [chemical binding]; other site 484021013359 Q-loop/lid; other site 484021013360 ABC transporter signature motif; other site 484021013361 Walker B; other site 484021013362 D-loop; other site 484021013363 H-loop/switch region; other site 484021013364 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 484021013365 MutS domain I; Region: MutS_I; pfam01624 484021013366 MutS domain II; Region: MutS_II; pfam05188 484021013367 MutS domain III; Region: MutS_III; pfam05192 484021013368 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 484021013369 Walker A/P-loop; other site 484021013370 ATP binding site [chemical binding]; other site 484021013371 Q-loop/lid; other site 484021013372 ABC transporter signature motif; other site 484021013373 Walker B; other site 484021013374 D-loop; other site 484021013375 H-loop/switch region; other site 484021013376 Hok/gef family; Region: HOK_GEF; pfam01848 484021013377 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 484021013378 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 484021013379 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 484021013380 Flavoprotein; Region: Flavoprotein; pfam02441 484021013381 MarR family; Region: MarR_2; cl17246 484021013382 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021013383 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021013384 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021013385 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021013386 putative effector binding pocket; other site 484021013387 dimerization interface [polypeptide binding]; other site 484021013388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021013389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013390 putative substrate translocation pore; other site 484021013391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 484021013392 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 484021013393 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 484021013394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484021013395 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 484021013396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484021013397 DNA binding residues [nucleotide binding] 484021013398 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 484021013399 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021013400 Peptidase family M23; Region: Peptidase_M23; pfam01551 484021013401 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 484021013402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021013403 S-adenosylmethionine binding site [chemical binding]; other site 484021013404 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 484021013405 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 484021013406 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 484021013407 Permutation of conserved domain; other site 484021013408 active site 484021013409 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 484021013410 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 484021013411 homotrimer interaction site [polypeptide binding]; other site 484021013412 zinc binding site [ion binding]; other site 484021013413 CDP-binding sites; other site 484021013414 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 484021013415 substrate binding site; other site 484021013416 dimer interface; other site 484021013417 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 484021013418 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 484021013419 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 484021013420 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 484021013421 ligand-binding site [chemical binding]; other site 484021013422 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 484021013423 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 484021013424 CysD dimerization site [polypeptide binding]; other site 484021013425 G1 box; other site 484021013426 putative GEF interaction site [polypeptide binding]; other site 484021013427 GTP/Mg2+ binding site [chemical binding]; other site 484021013428 Switch I region; other site 484021013429 G2 box; other site 484021013430 G3 box; other site 484021013431 Switch II region; other site 484021013432 G4 box; other site 484021013433 G5 box; other site 484021013434 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 484021013435 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 484021013436 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 484021013437 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 484021013438 Active Sites [active] 484021013439 siroheme synthase; Provisional; Region: cysG; PRK10637 484021013440 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 484021013441 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 484021013442 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 484021013443 active site 484021013444 SAM binding site [chemical binding]; other site 484021013445 homodimer interface [polypeptide binding]; other site 484021013446 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 484021013447 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 484021013448 metal binding site [ion binding]; metal-binding site 484021013449 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 484021013450 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 484021013451 Active Sites [active] 484021013452 sulfite reductase subunit beta; Provisional; Region: PRK13504 484021013453 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 484021013454 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 484021013455 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 484021013456 Flavodoxin; Region: Flavodoxin_1; pfam00258 484021013457 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 484021013458 FAD binding pocket [chemical binding]; other site 484021013459 FAD binding motif [chemical binding]; other site 484021013460 catalytic residues [active] 484021013461 NAD binding pocket [chemical binding]; other site 484021013462 phosphate binding motif [ion binding]; other site 484021013463 beta-alpha-beta structure motif; other site 484021013464 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 484021013465 active site 484021013466 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 484021013467 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 484021013468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021013469 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 484021013470 NAD(P) binding site [chemical binding]; other site 484021013471 active site 484021013472 enolase; Provisional; Region: eno; PRK00077 484021013473 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 484021013474 dimer interface [polypeptide binding]; other site 484021013475 metal binding site [ion binding]; metal-binding site 484021013476 substrate binding pocket [chemical binding]; other site 484021013477 CTP synthetase; Validated; Region: pyrG; PRK05380 484021013478 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 484021013479 Catalytic site [active] 484021013480 active site 484021013481 UTP binding site [chemical binding]; other site 484021013482 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 484021013483 active site 484021013484 putative oxyanion hole; other site 484021013485 catalytic triad [active] 484021013486 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 484021013487 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 484021013488 homodimer interface [polypeptide binding]; other site 484021013489 metal binding site [ion binding]; metal-binding site 484021013490 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 484021013491 homodimer interface [polypeptide binding]; other site 484021013492 active site 484021013493 putative chemical substrate binding site [chemical binding]; other site 484021013494 metal binding site [ion binding]; metal-binding site 484021013495 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 484021013496 HD domain; Region: HD_4; pfam13328 484021013497 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484021013498 synthetase active site [active] 484021013499 NTP binding site [chemical binding]; other site 484021013500 metal binding site [ion binding]; metal-binding site 484021013501 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 484021013502 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 484021013503 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 484021013504 TRAM domain; Region: TRAM; pfam01938 484021013505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021013506 S-adenosylmethionine binding site [chemical binding]; other site 484021013507 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 484021013508 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 484021013509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021013510 dimerization interface [polypeptide binding]; other site 484021013511 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021013512 dimer interface [polypeptide binding]; other site 484021013513 phosphorylation site [posttranslational modification] 484021013514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021013515 ATP binding site [chemical binding]; other site 484021013516 Mg2+ binding site [ion binding]; other site 484021013517 G-X-G motif; other site 484021013518 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 484021013519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021013520 active site 484021013521 phosphorylation site [posttranslational modification] 484021013522 intermolecular recognition site; other site 484021013523 dimerization interface [polypeptide binding]; other site 484021013524 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 484021013525 putative binding surface; other site 484021013526 active site 484021013527 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 484021013528 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 484021013529 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 484021013530 active site 484021013531 tetramer interface [polypeptide binding]; other site 484021013532 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 484021013533 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 484021013534 active site 484021013535 tetramer interface [polypeptide binding]; other site 484021013536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013537 D-galactonate transporter; Region: 2A0114; TIGR00893 484021013538 putative substrate translocation pore; other site 484021013539 flavodoxin; Provisional; Region: PRK08105 484021013540 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 484021013541 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 484021013542 probable active site [active] 484021013543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 484021013544 SecY interacting protein Syd; Provisional; Region: PRK04968 484021013545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 484021013546 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 484021013547 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 484021013548 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 484021013549 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 484021013550 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484021013551 serine transporter; Region: stp; TIGR00814 484021013552 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 484021013553 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 484021013554 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 484021013555 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 484021013556 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021013557 substrate binding pocket [chemical binding]; other site 484021013558 membrane-bound complex binding site; other site 484021013559 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 484021013560 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 484021013561 Flavin binding site [chemical binding]; other site 484021013562 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013563 putative substrate translocation pore; other site 484021013564 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 484021013565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013566 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 484021013567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021013568 dimer interface [polypeptide binding]; other site 484021013569 conserved gate region; other site 484021013570 ABC-ATPase subunit interface; other site 484021013571 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 484021013572 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 484021013573 Walker A/P-loop; other site 484021013574 ATP binding site [chemical binding]; other site 484021013575 Q-loop/lid; other site 484021013576 ABC transporter signature motif; other site 484021013577 Walker B; other site 484021013578 D-loop; other site 484021013579 H-loop/switch region; other site 484021013580 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 484021013581 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 484021013582 active site 484021013583 non-prolyl cis peptide bond; other site 484021013584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 484021013585 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 484021013586 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 484021013587 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 484021013588 active site 484021013589 dimer interface [polypeptide binding]; other site 484021013590 non-prolyl cis peptide bond; other site 484021013591 insertion regions; other site 484021013592 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 484021013593 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021013594 Walker A motif; other site 484021013595 ATP binding site [chemical binding]; other site 484021013596 Walker B motif; other site 484021013597 arginine finger; other site 484021013598 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021013599 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 484021013600 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021013601 substrate binding pocket [chemical binding]; other site 484021013602 membrane-bound complex binding site; other site 484021013603 hinge residues; other site 484021013604 flap endonuclease-like protein; Provisional; Region: PRK09482 484021013605 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 484021013606 active site 484021013607 metal binding site 1 [ion binding]; metal-binding site 484021013608 putative 5' ssDNA interaction site; other site 484021013609 metal binding site 3; metal-binding site 484021013610 metal binding site 2 [ion binding]; metal-binding site 484021013611 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 484021013612 putative DNA binding site [nucleotide binding]; other site 484021013613 putative metal binding site [ion binding]; other site 484021013614 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 484021013615 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 484021013616 dimer interface [polypeptide binding]; other site 484021013617 active site 484021013618 metal binding site [ion binding]; metal-binding site 484021013619 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 484021013620 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 484021013621 intersubunit interface [polypeptide binding]; other site 484021013622 active site 484021013623 Zn2+ binding site [ion binding]; other site 484021013624 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 484021013625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013626 putative substrate translocation pore; other site 484021013627 L-fucose isomerase; Provisional; Region: fucI; PRK10991 484021013628 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 484021013629 hexamer (dimer of trimers) interface [polypeptide binding]; other site 484021013630 trimer interface [polypeptide binding]; other site 484021013631 substrate binding site [chemical binding]; other site 484021013632 Mn binding site [ion binding]; other site 484021013633 L-fuculokinase; Provisional; Region: PRK10331 484021013634 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484021013635 nucleotide binding site [chemical binding]; other site 484021013636 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 484021013637 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 484021013638 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021013639 DNA-binding site [nucleotide binding]; DNA binding site 484021013640 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021013641 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 484021013642 FtsJ-like methyltransferase; Region: FtsJ; cl17430 484021013643 hypothetical protein; Provisional; Region: PRK10873 484021013644 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 484021013645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021013646 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021013647 dimerization interface [polypeptide binding]; other site 484021013648 substrate binding pocket [chemical binding]; other site 484021013649 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 484021013650 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 484021013651 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 484021013652 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021013653 catalytic residue [active] 484021013654 Fe-S metabolism associated domain; Region: SufE; cl00951 484021013655 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 484021013656 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 484021013657 putative ATP binding site [chemical binding]; other site 484021013658 putative substrate interface [chemical binding]; other site 484021013659 murein transglycosylase A; Provisional; Region: mltA; PRK11162 484021013660 MltA specific insert domain; Region: MltA; pfam03562 484021013661 3D domain; Region: 3D; pfam06725 484021013662 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 484021013663 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 484021013664 putative dimer interface [polypeptide binding]; other site 484021013665 active site pocket [active] 484021013666 putative cataytic base [active] 484021013667 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 484021013668 homotrimer interface [polypeptide binding]; other site 484021013669 Walker A motif; other site 484021013670 GTP binding site [chemical binding]; other site 484021013671 Walker B motif; other site 484021013672 cobyric acid synthase; Provisional; Region: PRK00784 484021013673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021013674 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021013675 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 484021013676 catalytic triad [active] 484021013677 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 484021013678 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 484021013679 Walker A/P-loop; other site 484021013680 ATP binding site [chemical binding]; other site 484021013681 Q-loop/lid; other site 484021013682 ABC transporter signature motif; other site 484021013683 Walker B; other site 484021013684 D-loop; other site 484021013685 H-loop/switch region; other site 484021013686 cobalt transport protein CbiQ; Provisional; Region: PRK15485 484021013687 cobalt transport protein CbiN; Provisional; Region: PRK02898 484021013688 cobalt transport protein CbiM; Validated; Region: PRK08319 484021013689 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 484021013690 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 484021013691 active site 484021013692 SAM binding site [chemical binding]; other site 484021013693 homodimer interface [polypeptide binding]; other site 484021013694 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 484021013695 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 484021013696 active site 484021013697 C-terminal domain interface [polypeptide binding]; other site 484021013698 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 484021013699 active site 484021013700 N-terminal domain interface [polypeptide binding]; other site 484021013701 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 484021013702 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 484021013703 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 484021013704 active site 484021013705 SAM binding site [chemical binding]; other site 484021013706 homodimer interface [polypeptide binding]; other site 484021013707 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 484021013708 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 484021013709 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 484021013710 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 484021013711 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 484021013712 active site 484021013713 SAM binding site [chemical binding]; other site 484021013714 homodimer interface [polypeptide binding]; other site 484021013715 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 484021013716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021013717 S-adenosylmethionine binding site [chemical binding]; other site 484021013718 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 484021013719 active site 484021013720 putative homodimer interface [polypeptide binding]; other site 484021013721 SAM binding site [chemical binding]; other site 484021013722 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 484021013723 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 484021013724 Precorrin-8X methylmutase; Region: CbiC; pfam02570 484021013725 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 484021013726 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 484021013727 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 484021013728 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 484021013729 catalytic triad [active] 484021013730 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 484021013731 Sensory domain found in PocR; Region: PocR; pfam10114 484021013732 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484021013733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021013734 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021013735 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 484021013736 amphipathic channel; other site 484021013737 Asn-Pro-Ala signature motifs; other site 484021013738 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 484021013739 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 484021013740 Hexamer interface [polypeptide binding]; other site 484021013741 Putative hexagonal pore residue; other site 484021013742 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816 484021013743 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 484021013744 putative hexamer interface [polypeptide binding]; other site 484021013745 putative hexagonal pore; other site 484021013746 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 484021013747 putative hexamer interface [polypeptide binding]; other site 484021013748 putative hexagonal pore; other site 484021013749 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 484021013750 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 484021013751 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 484021013752 alpha-beta subunit interface [polypeptide binding]; other site 484021013753 alpha-gamma subunit interface [polypeptide binding]; other site 484021013754 active site 484021013755 substrate and K+ binding site; other site 484021013756 K+ binding site [ion binding]; other site 484021013757 cobalamin binding site [chemical binding]; other site 484021013758 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 484021013759 Propanediol dehydratase, small subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduE; COG4910 484021013760 Cell division protein FtsA; Region: FtsA; cl17206 484021013761 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 484021013762 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 484021013763 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 484021013764 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 484021013765 Hexamer interface [polypeptide binding]; other site 484021013766 Putative hexagonal pore residue; other site 484021013767 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 484021013768 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 484021013769 Hexamer interface [polypeptide binding]; other site 484021013770 Hexagonal pore residue; other site 484021013771 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 484021013772 Propanediol utilisation protein PduL; Region: PduL; pfam06130 484021013773 Propanediol utilisation protein PduL; Region: PduL; pfam06130 484021013774 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 484021013775 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 484021013776 Hexamer/Pentamer interface [polypeptide binding]; other site 484021013777 central pore; other site 484021013778 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 484021013779 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 484021013780 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 484021013781 putative catalytic cysteine [active] 484021013782 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 484021013783 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 484021013784 active site 484021013785 NAD binding site [chemical binding]; other site 484021013786 metal binding site [ion binding]; metal-binding site 484021013787 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 484021013788 SLBB domain; Region: SLBB; pfam10531 484021013789 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 484021013790 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 484021013791 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 484021013792 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 484021013793 putative hexamer interface [polypeptide binding]; other site 484021013794 putative hexagonal pore; other site 484021013795 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 484021013796 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 484021013797 putative hexamer interface [polypeptide binding]; other site 484021013798 putative hexagonal pore; other site 484021013799 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 484021013800 putative hexamer interface [polypeptide binding]; other site 484021013801 putative hexagonal pore; other site 484021013802 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 484021013803 G1 box; other site 484021013804 GTP/Mg2+ binding site [chemical binding]; other site 484021013805 G2 box; other site 484021013806 G3 box; other site 484021013807 Switch II region; other site 484021013808 G4 box; other site 484021013809 G5 box; other site 484021013810 propionate kinase; Reviewed; Region: PRK12397 484021013811 propionate/acetate kinase; Provisional; Region: PRK12379 484021013812 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 484021013813 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 484021013814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021013815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021013816 homodimer interface [polypeptide binding]; other site 484021013817 catalytic residue [active] 484021013818 AMIN domain; Region: AMIN; pfam11741 484021013819 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 484021013820 active site 484021013821 metal binding site [ion binding]; metal-binding site 484021013822 N-acetylglutamate synthase; Validated; Region: PRK05279 484021013823 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 484021013824 putative feedback inhibition sensing region; other site 484021013825 putative nucleotide binding site [chemical binding]; other site 484021013826 putative substrate binding site [chemical binding]; other site 484021013827 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021013828 Coenzyme A binding pocket [chemical binding]; other site 484021013829 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 484021013830 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 484021013831 Family description; Region: UvrD_C_2; pfam13538 484021013832 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 484021013833 protease3; Provisional; Region: PRK15101 484021013834 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 484021013835 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484021013836 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484021013837 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 484021013838 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 484021013839 hypothetical protein; Provisional; Region: PRK10332 484021013840 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 484021013841 hypothetical protein; Provisional; Region: PRK11521 484021013842 hypothetical protein; Provisional; Region: PRK10557 484021013843 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 484021013844 hypothetical protein; Provisional; Region: PRK10506 484021013845 thymidylate synthase; Reviewed; Region: thyA; PRK01827 484021013846 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 484021013847 dimerization interface [polypeptide binding]; other site 484021013848 active site 484021013849 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 484021013850 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 484021013851 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 484021013852 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 484021013853 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484021013854 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 484021013855 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 484021013856 putative active site [active] 484021013857 Ap4A binding site [chemical binding]; other site 484021013858 nudix motif; other site 484021013859 putative metal binding site [ion binding]; other site 484021013860 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 484021013861 putative DNA-binding cleft [nucleotide binding]; other site 484021013862 putative DNA clevage site; other site 484021013863 molecular lever; other site 484021013864 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 484021013865 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 484021013866 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021013867 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021013868 active site 484021013869 catalytic tetrad [active] 484021013870 lysophospholipid transporter LplT; Provisional; Region: PRK11195 484021013871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013872 putative substrate translocation pore; other site 484021013873 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 484021013874 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484021013875 putative acyl-acceptor binding pocket; other site 484021013876 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 484021013877 acyl-activating enzyme (AAE) consensus motif; other site 484021013878 putative AMP binding site [chemical binding]; other site 484021013879 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 484021013880 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021013881 DNA binding site [nucleotide binding] 484021013882 domain linker motif; other site 484021013883 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 484021013884 dimerization interface (closed form) [polypeptide binding]; other site 484021013885 ligand binding site [chemical binding]; other site 484021013886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021013887 Coenzyme A binding pocket [chemical binding]; other site 484021013888 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 484021013889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021013890 DNA-binding site [nucleotide binding]; DNA binding site 484021013891 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 484021013892 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 484021013893 beta-galactosidase; Region: BGL; TIGR03356 484021013894 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484021013895 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021013896 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021013897 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021013898 DNA binding site [nucleotide binding] 484021013899 domain linker motif; other site 484021013900 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 484021013901 dimerization interface (closed form) [polypeptide binding]; other site 484021013902 ligand binding site [chemical binding]; other site 484021013903 diaminopimelate decarboxylase; Provisional; Region: PRK11165 484021013904 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 484021013905 active site 484021013906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484021013907 substrate binding site [chemical binding]; other site 484021013908 catalytic residues [active] 484021013909 dimer interface [polypeptide binding]; other site 484021013910 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 484021013911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021013912 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021013913 dimerization interface [polypeptide binding]; other site 484021013914 putative racemase; Provisional; Region: PRK10200 484021013915 aspartate racemase; Region: asp_race; TIGR00035 484021013916 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021013917 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021013918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021013919 dimer interface [polypeptide binding]; other site 484021013920 conserved gate region; other site 484021013921 putative PBP binding loops; other site 484021013922 ABC-ATPase subunit interface; other site 484021013923 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484021013924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021013925 dimer interface [polypeptide binding]; other site 484021013926 conserved gate region; other site 484021013927 putative PBP binding loops; other site 484021013928 ABC-ATPase subunit interface; other site 484021013929 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 484021013930 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 484021013931 Walker A/P-loop; other site 484021013932 ATP binding site [chemical binding]; other site 484021013933 Q-loop/lid; other site 484021013934 ABC transporter signature motif; other site 484021013935 Walker B; other site 484021013936 D-loop; other site 484021013937 H-loop/switch region; other site 484021013938 TOBE domain; Region: TOBE; pfam03459 484021013939 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 484021013940 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 484021013941 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 484021013942 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 484021013943 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 484021013944 substrate binding [chemical binding]; other site 484021013945 active site 484021013946 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 484021013947 galactoside permease; Reviewed; Region: lacY; PRK09528 484021013948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013949 putative substrate translocation pore; other site 484021013950 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021013951 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021013952 DNA binding site [nucleotide binding] 484021013953 domain linker motif; other site 484021013954 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 484021013955 putative dimerization interface [polypeptide binding]; other site 484021013956 putative ligand binding site [chemical binding]; other site 484021013957 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 484021013958 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013959 putative substrate translocation pore; other site 484021013960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021013961 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 484021013962 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 484021013963 NADP binding site [chemical binding]; other site 484021013964 homodimer interface [polypeptide binding]; other site 484021013965 active site 484021013966 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 484021013967 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 484021013968 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 484021013969 putative acyltransferase; Provisional; Region: PRK05790 484021013970 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 484021013971 dimer interface [polypeptide binding]; other site 484021013972 active site 484021013973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021013974 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021013975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484021013976 dimerization interface [polypeptide binding]; other site 484021013977 Predicted membrane protein [Function unknown]; Region: COG4125 484021013978 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 484021013979 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 484021013980 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484021013981 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 484021013982 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021013983 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021013984 active site 484021013985 catalytic tetrad [active] 484021013986 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 484021013987 PilZ domain; Region: PilZ; pfam07238 484021013988 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021013989 DNA binding residues [nucleotide binding] 484021013990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021013991 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021013992 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021013993 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 484021013994 PapC N-terminal domain; Region: PapC_N; pfam13954 484021013995 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021013996 PapC C-terminal domain; Region: PapC_C; pfam13953 484021013997 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 484021013998 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021013999 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021014000 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021014001 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021014002 EamA-like transporter family; Region: EamA; pfam00892 484021014003 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484021014004 EamA-like transporter family; Region: EamA; pfam00892 484021014005 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 484021014006 MarR family; Region: MarR; pfam01047 484021014007 MarR family; Region: MarR_2; cl17246 484021014008 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 484021014009 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 484021014010 Int/Topo IB signature motif; other site 484021014011 tyrosine recombinase; Provisional; Region: PRK09871 484021014012 active site 484021014013 DNA binding site [nucleotide binding] 484021014014 Int/Topo IB signature motif; other site 484021014015 Fimbrial protein; Region: Fimbrial; cl01416 484021014016 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021014017 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 484021014018 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 484021014019 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 484021014020 outer membrane usher protein; Provisional; Region: PRK15193 484021014021 PapC N-terminal domain; Region: PapC_N; pfam13954 484021014022 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 484021014023 PapC C-terminal domain; Region: PapC_C; pfam13953 484021014024 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021014025 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 484021014026 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 484021014027 mannosyl binding site [chemical binding]; other site 484021014028 Fimbrial protein; Region: Fimbrial; cl01416 484021014029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 484021014030 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021014031 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021014032 Coenzyme A binding pocket [chemical binding]; other site 484021014033 Uncharacterized conserved protein [Function unknown]; Region: COG3592 484021014034 multidrug resistance protein MdtN; Provisional; Region: PRK10476 484021014035 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021014036 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021014037 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 484021014038 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 484021014039 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 484021014040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021014041 putative substrate translocation pore; other site 484021014042 POT family; Region: PTR2; cl17359 484021014043 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 484021014044 ArsC family; Region: ArsC; pfam03960 484021014045 catalytic residues [active] 484021014046 arsenical pump membrane protein; Provisional; Region: PRK15445 484021014047 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 484021014048 transmembrane helices; other site 484021014049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021014050 dimerization interface [polypeptide binding]; other site 484021014051 putative DNA binding site [nucleotide binding]; other site 484021014052 putative Zn2+ binding site [ion binding]; other site 484021014053 YCII-related domain; Region: YCII; cl00999 484021014054 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 484021014055 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021014056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021014057 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021014058 dimerization interface [polypeptide binding]; other site 484021014059 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 484021014060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021014061 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021014062 active site 484021014063 catalytic tetrad [active] 484021014064 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 484021014065 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 484021014066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021014067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021014068 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 484021014069 putative substrate binding pocket [chemical binding]; other site 484021014070 putative dimerization interface [polypeptide binding]; other site 484021014071 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021014072 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484021014073 putative substrate translocation pore; other site 484021014074 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484021014075 Peptidase family M23; Region: Peptidase_M23; pfam01551 484021014076 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 484021014077 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 484021014078 active site 484021014079 metal binding site [ion binding]; metal-binding site 484021014080 nudix motif; other site 484021014081 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 484021014082 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 484021014083 dimer interface [polypeptide binding]; other site 484021014084 putative anticodon binding site; other site 484021014085 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 484021014086 motif 1; other site 484021014087 active site 484021014088 motif 2; other site 484021014089 motif 3; other site 484021014090 peptide chain release factor 2; Provisional; Region: PRK08787 484021014091 This domain is found in peptide chain release factors; Region: PCRF; smart00937 484021014092 RF-1 domain; Region: RF-1; pfam00472 484021014093 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 484021014094 DHH family; Region: DHH; pfam01368 484021014095 DHHA1 domain; Region: DHHA1; pfam02272 484021014096 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 484021014097 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 484021014098 dimerization domain [polypeptide binding]; other site 484021014099 dimer interface [polypeptide binding]; other site 484021014100 catalytic residues [active] 484021014101 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 484021014102 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 484021014103 active site 484021014104 Int/Topo IB signature motif; other site 484021014105 flavodoxin FldB; Provisional; Region: PRK12359 484021014106 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 484021014107 hypothetical protein; Provisional; Region: PRK10878 484021014108 putative global regulator; Reviewed; Region: PRK09559 484021014109 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 484021014110 hemolysin; Provisional; Region: PRK15087 484021014111 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 484021014112 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 484021014113 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021014114 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021014115 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021014116 putative active site [active] 484021014117 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 484021014118 beta-galactosidase; Region: BGL; TIGR03356 484021014119 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 484021014120 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 484021014121 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 484021014122 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 484021014123 DsbD alpha interface [polypeptide binding]; other site 484021014124 catalytic residues [active] 484021014125 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 484021014126 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 484021014127 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 484021014128 catalytic residues [active] 484021014129 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 484021014130 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484021014131 catalytic residues [active] 484021014132 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 484021014133 classical (c) SDRs; Region: SDR_c; cd05233 484021014134 NAD(P) binding site [chemical binding]; other site 484021014135 active site 484021014136 glycine dehydrogenase; Provisional; Region: PRK05367 484021014137 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 484021014138 tetramer interface [polypeptide binding]; other site 484021014139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014140 catalytic residue [active] 484021014141 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 484021014142 tetramer interface [polypeptide binding]; other site 484021014143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014144 catalytic residue [active] 484021014145 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 484021014146 lipoyl attachment site [posttranslational modification]; other site 484021014147 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 484021014148 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 484021014149 oxidoreductase; Provisional; Region: PRK08013 484021014150 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 484021014151 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 484021014152 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 484021014153 proline aminopeptidase P II; Provisional; Region: PRK10879 484021014154 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 484021014155 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 484021014156 active site 484021014157 hypothetical protein; Reviewed; Region: PRK01736 484021014158 Z-ring-associated protein; Provisional; Region: PRK10972 484021014159 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 484021014160 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 484021014161 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 484021014162 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 484021014163 ligand binding site [chemical binding]; other site 484021014164 NAD binding site [chemical binding]; other site 484021014165 tetramer interface [polypeptide binding]; other site 484021014166 catalytic site [active] 484021014167 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 484021014168 L-serine binding site [chemical binding]; other site 484021014169 ACT domain interface; other site 484021014170 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 484021014171 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021014172 active site 484021014173 dimer interface [polypeptide binding]; other site 484021014174 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 484021014175 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021014176 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 484021014177 putative dimerization interface [polypeptide binding]; other site 484021014178 oxidative stress defense protein; Provisional; Region: PRK11087 484021014179 Uncharacterized conserved protein [Function unknown]; Region: COG2968 484021014180 arginine exporter protein; Provisional; Region: PRK09304 484021014181 mechanosensitive channel MscS; Provisional; Region: PRK10334 484021014182 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484021014183 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 484021014184 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 484021014185 active site 484021014186 intersubunit interface [polypeptide binding]; other site 484021014187 zinc binding site [ion binding]; other site 484021014188 Na+ binding site [ion binding]; other site 484021014189 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 484021014190 Phosphoglycerate kinase; Region: PGK; pfam00162 484021014191 substrate binding site [chemical binding]; other site 484021014192 hinge regions; other site 484021014193 ADP binding site [chemical binding]; other site 484021014194 catalytic site [active] 484021014195 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 484021014196 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 484021014197 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 484021014198 transketolase; Reviewed; Region: PRK12753 484021014199 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484021014200 TPP-binding site [chemical binding]; other site 484021014201 dimer interface [polypeptide binding]; other site 484021014202 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484021014203 PYR/PP interface [polypeptide binding]; other site 484021014204 dimer interface [polypeptide binding]; other site 484021014205 TPP binding site [chemical binding]; other site 484021014206 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484021014207 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 484021014208 outer membrane porin, OprD family; Region: OprD; pfam03573 484021014209 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 484021014210 agmatinase; Region: agmatinase; TIGR01230 484021014211 oligomer interface [polypeptide binding]; other site 484021014212 putative active site [active] 484021014213 Mn binding site [ion binding]; other site 484021014214 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 484021014215 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 484021014216 dimer interface [polypeptide binding]; other site 484021014217 active site 484021014218 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484021014219 catalytic residues [active] 484021014220 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 484021014221 S-adenosylmethionine synthetase; Validated; Region: PRK05250 484021014222 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 484021014223 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 484021014224 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 484021014225 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 484021014226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021014227 putative substrate translocation pore; other site 484021014228 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 484021014229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021014230 hypothetical protein; Provisional; Region: PRK04860 484021014231 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 484021014232 DNA-specific endonuclease I; Provisional; Region: PRK15137 484021014233 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 484021014234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 484021014235 RNA methyltransferase, RsmE family; Region: TIGR00046 484021014236 glutathione synthetase; Provisional; Region: PRK05246 484021014237 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 484021014238 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 484021014239 hypothetical protein; Validated; Region: PRK00228 484021014240 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 484021014241 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 484021014242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021014243 DNA binding residues [nucleotide binding] 484021014244 dimerization interface [polypeptide binding]; other site 484021014245 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 484021014246 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 484021014247 Walker A motif; other site 484021014248 ATP binding site [chemical binding]; other site 484021014249 Walker B motif; other site 484021014250 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 484021014251 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484021014252 catalytic residue [active] 484021014253 YGGT family; Region: YGGT; pfam02325 484021014254 YGGT family; Region: YGGT; pfam02325 484021014255 hypothetical protein; Validated; Region: PRK05090 484021014256 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 484021014257 active site 484021014258 dimerization interface [polypeptide binding]; other site 484021014259 HemN family oxidoreductase; Provisional; Region: PRK05660 484021014260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021014261 FeS/SAM binding site; other site 484021014262 HemN C-terminal domain; Region: HemN_C; pfam06969 484021014263 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 484021014264 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 484021014265 putative ligand binding site [chemical binding]; other site 484021014266 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484021014267 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021014268 Walker A/P-loop; other site 484021014269 ATP binding site [chemical binding]; other site 484021014270 Q-loop/lid; other site 484021014271 ABC transporter signature motif; other site 484021014272 Walker B; other site 484021014273 D-loop; other site 484021014274 H-loop/switch region; other site 484021014275 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 484021014276 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021014277 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021014278 TM-ABC transporter signature motif; other site 484021014279 hypothetical protein; Provisional; Region: PRK10626 484021014280 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 484021014281 hypothetical protein; Provisional; Region: PRK11702 484021014282 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 484021014283 adenine DNA glycosylase; Provisional; Region: PRK10880 484021014284 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484021014285 minor groove reading motif; other site 484021014286 helix-hairpin-helix signature motif; other site 484021014287 substrate binding pocket [chemical binding]; other site 484021014288 active site 484021014289 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 484021014290 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 484021014291 DNA binding and oxoG recognition site [nucleotide binding] 484021014292 oxidative damage protection protein; Provisional; Region: PRK05408 484021014293 murein transglycosylase C; Provisional; Region: mltC; PRK11671 484021014294 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 484021014295 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484021014296 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484021014297 catalytic residue [active] 484021014298 nucleoside transporter; Region: 2A0110; TIGR00889 484021014299 ornithine decarboxylase; Provisional; Region: PRK13578 484021014300 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 484021014301 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 484021014302 homodimer interface [polypeptide binding]; other site 484021014303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014304 catalytic residue [active] 484021014305 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 484021014306 Protein of unknown function (DUF554); Region: DUF554; pfam04474 484021014307 Transposase; Region: HTH_Tnp_1; cl17663 484021014308 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021014309 Coenzyme A binding pocket [chemical binding]; other site 484021014310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 484021014311 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484021014312 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 484021014313 dimer interface [polypeptide binding]; other site 484021014314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014315 catalytic residue [active] 484021014316 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 484021014317 FOG: CBS domain [General function prediction only]; Region: COG0517 484021014318 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 484021014319 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484021014320 homodimer interface [polypeptide binding]; other site 484021014321 substrate-cofactor binding pocket; other site 484021014322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014323 catalytic residue [active] 484021014324 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021014325 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021014326 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 484021014327 putative effector binding pocket; other site 484021014328 putative dimerization interface [polypeptide binding]; other site 484021014329 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 484021014330 putative NAD(P) binding site [chemical binding]; other site 484021014331 homodimer interface [polypeptide binding]; other site 484021014332 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 484021014333 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021014334 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014335 homodimer interface [polypeptide binding]; other site 484021014336 catalytic residue [active] 484021014337 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 484021014338 CHAP domain; Region: CHAP; pfam05257 484021014339 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 484021014340 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021014341 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021014342 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484021014343 Thioredoxin; Region: Thioredoxin_4; cl17273 484021014344 putative S-transferase; Provisional; Region: PRK11752 484021014345 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 484021014346 C-terminal domain interface [polypeptide binding]; other site 484021014347 GSH binding site (G-site) [chemical binding]; other site 484021014348 dimer interface [polypeptide binding]; other site 484021014349 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 484021014350 dimer interface [polypeptide binding]; other site 484021014351 N-terminal domain interface [polypeptide binding]; other site 484021014352 active site 484021014353 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 484021014354 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 484021014355 hypothetical protein; Provisional; Region: PRK05208 484021014356 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 484021014357 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 484021014358 active site 484021014359 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 484021014360 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484021014361 biopolymer transport protein ExbD; Provisional; Region: PRK11267 484021014362 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 484021014363 biopolymer transport protein ExbB; Provisional; Region: PRK10414 484021014364 cystathionine beta-lyase; Provisional; Region: PRK08114 484021014365 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484021014366 homodimer interface [polypeptide binding]; other site 484021014367 substrate-cofactor binding pocket; other site 484021014368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014369 catalytic residue [active] 484021014370 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484021014371 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 484021014372 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 484021014373 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484021014374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021014375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021014376 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 484021014377 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 484021014378 dimer interface [polypeptide binding]; other site 484021014379 active site 484021014380 metal binding site [ion binding]; metal-binding site 484021014381 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484021014382 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484021014383 active site 484021014384 catalytic tetrad [active] 484021014385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021014386 Coenzyme A binding pocket [chemical binding]; other site 484021014387 hypothetical protein; Provisional; Region: PRK01254 484021014388 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 484021014389 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 484021014390 FtsI repressor; Provisional; Region: PRK10883 484021014391 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 484021014392 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 484021014393 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484021014394 putative acyl-acceptor binding pocket; other site 484021014395 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 484021014396 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 484021014397 CAP-like domain; other site 484021014398 active site 484021014399 primary dimer interface [polypeptide binding]; other site 484021014400 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021014401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021014402 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 484021014403 Periplasmic protein with OB-fold [Function unknown]; Region: COG3111 484021014404 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 484021014405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021014406 active site 484021014407 phosphorylation site [posttranslational modification] 484021014408 intermolecular recognition site; other site 484021014409 dimerization interface [polypeptide binding]; other site 484021014410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021014411 DNA binding site [nucleotide binding] 484021014412 sensor protein QseC; Provisional; Region: PRK10337 484021014413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021014414 dimer interface [polypeptide binding]; other site 484021014415 phosphorylation site [posttranslational modification] 484021014416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021014417 ATP binding site [chemical binding]; other site 484021014418 Mg2+ binding site [ion binding]; other site 484021014419 G-X-G motif; other site 484021014420 potential frameshift: common BLAST hit: gi|152971959|ref|YP_001337068.1| modulator of drug activity B 484021014421 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 484021014422 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 484021014423 Uncharacterized conserved protein [Function unknown]; Region: COG1359 484021014424 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 484021014425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021014426 ATP binding site [chemical binding]; other site 484021014427 Mg2+ binding site [ion binding]; other site 484021014428 G-X-G motif; other site 484021014429 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 484021014430 anchoring element; other site 484021014431 dimer interface [polypeptide binding]; other site 484021014432 ATP binding site [chemical binding]; other site 484021014433 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 484021014434 active site 484021014435 metal binding site [ion binding]; metal-binding site 484021014436 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484021014437 esterase YqiA; Provisional; Region: PRK11071 484021014438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484021014439 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 484021014440 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 484021014441 active site 484021014442 metal binding site [ion binding]; metal-binding site 484021014443 hexamer interface [polypeptide binding]; other site 484021014444 putative dehydrogenase; Provisional; Region: PRK11039 484021014445 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 484021014446 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484021014447 dimer interface [polypeptide binding]; other site 484021014448 ADP-ribose binding site [chemical binding]; other site 484021014449 active site 484021014450 nudix motif; other site 484021014451 metal binding site [ion binding]; metal-binding site 484021014452 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 484021014453 hypothetical protein; Provisional; Region: PRK11653 484021014454 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 484021014455 potential protein location (hypothetical protein) that overlaps protein (putative enzyme with dioxygenase domain) 484021014456 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 484021014457 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 484021014458 putative active site [active] 484021014459 metal binding site [ion binding]; metal-binding site 484021014460 zinc transporter ZupT; Provisional; Region: PRK04201 484021014461 ZIP Zinc transporter; Region: Zip; pfam02535 484021014462 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 484021014463 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 484021014464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 484021014465 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 484021014466 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 484021014467 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 484021014468 putative ribose interaction site [chemical binding]; other site 484021014469 putative ADP binding site [chemical binding]; other site 484021014470 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 484021014471 active site 484021014472 nucleotide binding site [chemical binding]; other site 484021014473 HIGH motif; other site 484021014474 KMSKS motif; other site 484021014475 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 484021014476 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 484021014477 metal binding triad; other site 484021014478 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 484021014479 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 484021014480 metal binding triad; other site 484021014481 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 484021014482 Uncharacterized conserved protein [Function unknown]; Region: COG3025 484021014483 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 484021014484 putative active site [active] 484021014485 putative metal binding residues [ion binding]; other site 484021014486 signature motif; other site 484021014487 putative triphosphate binding site [ion binding]; other site 484021014488 SH3 domain-containing protein; Provisional; Region: PRK10884 484021014489 Bacterial SH3 domain homologues; Region: SH3b; smart00287 484021014490 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 484021014491 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 484021014492 active site 484021014493 NTP binding site [chemical binding]; other site 484021014494 metal binding triad [ion binding]; metal-binding site 484021014495 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 484021014496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021014497 Zn2+ binding site [ion binding]; other site 484021014498 Mg2+ binding site [ion binding]; other site 484021014499 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 484021014500 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 484021014501 homooctamer interface [polypeptide binding]; other site 484021014502 active site 484021014503 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 484021014504 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021014505 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021014506 UreD urease accessory protein; Region: UreD; cl00530 484021014507 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 484021014508 alpha-gamma subunit interface [polypeptide binding]; other site 484021014509 beta-gamma subunit interface [polypeptide binding]; other site 484021014510 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 484021014511 gamma-beta subunit interface [polypeptide binding]; other site 484021014512 alpha-beta subunit interface [polypeptide binding]; other site 484021014513 urease subunit alpha; Reviewed; Region: ureC; PRK13207 484021014514 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 484021014515 subunit interactions [polypeptide binding]; other site 484021014516 active site 484021014517 flap region; other site 484021014518 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 484021014519 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 484021014520 dimer interface [polypeptide binding]; other site 484021014521 catalytic residues [active] 484021014522 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 484021014523 UreF; Region: UreF; pfam01730 484021014524 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021014525 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 484021014526 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 484021014527 UGMP family protein; Validated; Region: PRK09604 484021014528 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 484021014529 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 484021014530 DNA primase; Validated; Region: dnaG; PRK05667 484021014531 CHC2 zinc finger; Region: zf-CHC2; pfam01807 484021014532 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 484021014533 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 484021014534 active site 484021014535 metal binding site [ion binding]; metal-binding site 484021014536 interdomain interaction site; other site 484021014537 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 484021014538 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 484021014539 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 484021014540 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 484021014541 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 484021014542 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 484021014543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484021014544 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 484021014545 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484021014546 DNA binding residues [nucleotide binding] 484021014547 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 484021014548 active site 484021014549 SUMO-1 interface [polypeptide binding]; other site 484021014550 HdeA/HdeB family; Region: HdeA; pfam06411 484021014551 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 484021014552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021014553 active site 484021014554 phosphorylation site [posttranslational modification] 484021014555 intermolecular recognition site; other site 484021014556 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021014557 DNA binding residues [nucleotide binding] 484021014558 dimerization interface [polypeptide binding]; other site 484021014559 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 484021014560 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021014561 substrate binding pocket [chemical binding]; other site 484021014562 membrane-bound complex binding site; other site 484021014563 hinge residues; other site 484021014564 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021014565 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484021014566 substrate binding pocket [chemical binding]; other site 484021014567 membrane-bound complex binding site; other site 484021014568 hinge residues; other site 484021014569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484021014570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021014571 dimer interface [polypeptide binding]; other site 484021014572 phosphorylation site [posttranslational modification] 484021014573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021014574 ATP binding site [chemical binding]; other site 484021014575 Mg2+ binding site [ion binding]; other site 484021014576 G-X-G motif; other site 484021014577 Response regulator receiver domain; Region: Response_reg; pfam00072 484021014578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021014579 active site 484021014580 phosphorylation site [posttranslational modification] 484021014581 intermolecular recognition site; other site 484021014582 dimerization interface [polypeptide binding]; other site 484021014583 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 484021014584 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 484021014585 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021014586 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021014587 acid-resistance membrane protein; Provisional; Region: PRK10209 484021014588 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 484021014589 acid-resistance protein; Provisional; Region: hdeB; PRK11566 484021014590 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 484021014591 amphipathic channel; other site 484021014592 Asn-Pro-Ala signature motifs; other site 484021014593 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 484021014594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484021014595 Dehydratase small subunit; Region: Dehydratase_SU; pfam02287 484021014596 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 484021014597 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 484021014598 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 484021014599 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 484021014600 alpha-beta subunit interface [polypeptide binding]; other site 484021014601 alpha-gamma subunit interface [polypeptide binding]; other site 484021014602 active site 484021014603 substrate and K+ binding site; other site 484021014604 K+ binding site [ion binding]; other site 484021014605 cobalamin binding site [chemical binding]; other site 484021014606 Domain of unknown function (DUF336); Region: DUF336; pfam03928 484021014607 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 484021014608 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 484021014609 dimer interface [polypeptide binding]; other site 484021014610 active site 484021014611 metal binding site [ion binding]; metal-binding site 484021014612 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 484021014613 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 484021014614 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 484021014615 PAS domain; Region: PAS; smart00091 484021014616 putative active site [active] 484021014617 heme pocket [chemical binding]; other site 484021014618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021014619 Walker A motif; other site 484021014620 ATP binding site [chemical binding]; other site 484021014621 Walker B motif; other site 484021014622 arginine finger; other site 484021014623 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 484021014624 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 484021014625 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 484021014626 dimer interface [polypeptide binding]; other site 484021014627 active site 484021014628 metal binding site [ion binding]; metal-binding site 484021014629 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 484021014630 Dak1 domain; Region: Dak1; pfam02733 484021014631 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 484021014632 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 484021014633 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 484021014634 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484021014635 dimerization domain swap beta strand [polypeptide binding]; other site 484021014636 regulatory protein interface [polypeptide binding]; other site 484021014637 active site 484021014638 regulatory phosphorylation site [posttranslational modification]; other site 484021014639 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 484021014640 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484021014641 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 484021014642 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 484021014643 DAK2 domain; Region: Dak2; pfam02734 484021014644 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 484021014645 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 484021014646 FAD binding pocket [chemical binding]; other site 484021014647 FAD binding motif [chemical binding]; other site 484021014648 phosphate binding motif [ion binding]; other site 484021014649 NAD binding pocket [chemical binding]; other site 484021014650 Predicted transcriptional regulators [Transcription]; Region: COG1695 484021014651 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 484021014652 GLE1-like protein; Region: GLE1; pfam07817 484021014653 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 484021014654 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021014655 inhibitor-cofactor binding pocket; inhibition site 484021014656 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021014657 catalytic residue [active] 484021014658 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 484021014659 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 484021014660 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 484021014661 putative active site; other site 484021014662 catalytic residue [active] 484021014663 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 484021014664 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 484021014665 ligand binding site [chemical binding]; other site 484021014666 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021014667 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021014668 TM-ABC transporter signature motif; other site 484021014669 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021014670 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021014671 TM-ABC transporter signature motif; other site 484021014672 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 484021014673 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021014674 Walker A/P-loop; other site 484021014675 ATP binding site [chemical binding]; other site 484021014676 Q-loop/lid; other site 484021014677 ABC transporter signature motif; other site 484021014678 Walker B; other site 484021014679 D-loop; other site 484021014680 H-loop/switch region; other site 484021014681 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021014682 transcriptional regulator LsrR; Provisional; Region: PRK15418 484021014683 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 484021014684 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 484021014685 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 484021014686 putative N- and C-terminal domain interface [polypeptide binding]; other site 484021014687 putative active site [active] 484021014688 putative MgATP binding site [chemical binding]; other site 484021014689 catalytic site [active] 484021014690 metal binding site [ion binding]; metal-binding site 484021014691 putative carbohydrate binding site [chemical binding]; other site 484021014692 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 484021014693 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 484021014694 active site 484021014695 FMN binding site [chemical binding]; other site 484021014696 2,4-decadienoyl-CoA binding site; other site 484021014697 catalytic residue [active] 484021014698 4Fe-4S cluster binding site [ion binding]; other site 484021014699 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 484021014700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021014701 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 484021014702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021014703 S-adenosylmethionine binding site [chemical binding]; other site 484021014704 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 484021014705 B3/4 domain; Region: B3_4; pfam03483 484021014706 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484021014707 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021014708 non-specific DNA binding site [nucleotide binding]; other site 484021014709 salt bridge; other site 484021014710 sequence-specific DNA binding site [nucleotide binding]; other site 484021014711 Cupin domain; Region: Cupin_2; pfam07883 484021014712 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 484021014713 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484021014714 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021014715 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 484021014716 serine/threonine transporter SstT; Provisional; Region: PRK13628 484021014717 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484021014718 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 484021014719 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 484021014720 galactarate dehydratase; Region: galactar-dH20; TIGR03248 484021014721 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 484021014722 Glucuronate isomerase; Region: UxaC; pfam02614 484021014723 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 484021014724 D-galactonate transporter; Region: 2A0114; TIGR00893 484021014725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021014726 putative substrate translocation pore; other site 484021014727 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 484021014728 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021014729 DNA-binding site [nucleotide binding]; DNA binding site 484021014730 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 484021014731 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484021014732 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484021014733 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 484021014734 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 484021014735 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 484021014736 Predicted membrane protein [Function unknown]; Region: COG5393 484021014737 YqjK-like protein; Region: YqjK; pfam13997 484021014738 Predicted membrane protein [Function unknown]; Region: COG2259 484021014739 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 484021014740 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 484021014741 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 484021014742 putative dimer interface [polypeptide binding]; other site 484021014743 N-terminal domain interface [polypeptide binding]; other site 484021014744 putative substrate binding pocket (H-site) [chemical binding]; other site 484021014745 Predicted membrane protein [Function unknown]; Region: COG3152 484021014746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021014747 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 484021014748 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021014749 dimerization interface [polypeptide binding]; other site 484021014750 Pirin-related protein [General function prediction only]; Region: COG1741 484021014751 Pirin; Region: Pirin; pfam02678 484021014752 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 484021014753 dimer interface [polypeptide binding]; other site 484021014754 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 484021014755 glycerate kinase I; Provisional; Region: PRK10342 484021014756 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 484021014757 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 484021014758 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 484021014759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021014760 D-galactonate transporter; Region: 2A0114; TIGR00893 484021014761 putative substrate translocation pore; other site 484021014762 galactarate dehydratase; Region: galactar-dH20; TIGR03248 484021014763 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 484021014764 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 484021014765 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021014766 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484021014767 substrate binding site [chemical binding]; other site 484021014768 ATP binding site [chemical binding]; other site 484021014769 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021014770 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021014771 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021014772 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 484021014773 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 484021014774 intersubunit interface [polypeptide binding]; other site 484021014775 active site 484021014776 zinc binding site [ion binding]; other site 484021014777 Na+ binding site [ion binding]; other site 484021014778 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 484021014779 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 484021014780 putative substrate binding site [chemical binding]; other site 484021014781 putative ATP binding site [chemical binding]; other site 484021014782 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 484021014783 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 484021014784 active site 484021014785 P-loop; other site 484021014786 phosphorylation site [posttranslational modification] 484021014787 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 484021014788 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021014789 active site 484021014790 phosphorylation site [posttranslational modification] 484021014791 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484021014792 dimerization domain swap beta strand [polypeptide binding]; other site 484021014793 regulatory protein interface [polypeptide binding]; other site 484021014794 active site 484021014795 regulatory phosphorylation site [posttranslational modification]; other site 484021014796 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 484021014797 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021014798 active site 484021014799 phosphorylation site [posttranslational modification] 484021014800 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 484021014801 active site 484021014802 P-loop; other site 484021014803 phosphorylation site [posttranslational modification] 484021014804 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 484021014805 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 484021014806 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 484021014807 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 484021014808 putative NAD(P) binding site [chemical binding]; other site 484021014809 catalytic Zn binding site [ion binding]; other site 484021014810 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484021014811 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484021014812 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021014813 Fic family protein [Function unknown]; Region: COG3177 484021014814 Fic/DOC family; Region: Fic; pfam02661 484021014815 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484021014816 putative DNA binding site [nucleotide binding]; other site 484021014817 putative Zn2+ binding site [ion binding]; other site 484021014818 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 484021014819 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 484021014820 putative SAM binding site [chemical binding]; other site 484021014821 putative homodimer interface [polypeptide binding]; other site 484021014822 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484021014823 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 484021014824 putative ligand binding site [chemical binding]; other site 484021014825 hypothetical protein; Reviewed; Region: PRK12497 484021014826 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 484021014827 dimer interface [polypeptide binding]; other site 484021014828 active site 484021014829 outer membrane lipoprotein; Provisional; Region: PRK11023 484021014830 BON domain; Region: BON; pfam04972 484021014831 BON domain; Region: BON; pfam04972 484021014832 Predicted permease; Region: DUF318; pfam03773 484021014833 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 484021014834 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 484021014835 NAD binding site [chemical binding]; other site 484021014836 active site 484021014837 intracellular protease, PfpI family; Region: PfpI; TIGR01382 484021014838 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 484021014839 proposed catalytic triad [active] 484021014840 conserved cys residue [active] 484021014841 hypothetical protein; Provisional; Region: PRK03467 484021014842 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 484021014843 GIY-YIG motif/motif A; other site 484021014844 putative active site [active] 484021014845 putative metal binding site [ion binding]; other site 484021014846 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484021014847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021014848 Coenzyme A binding pocket [chemical binding]; other site 484021014849 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 484021014850 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 484021014851 Peptidase family U32; Region: Peptidase_U32; pfam01136 484021014852 putative protease; Provisional; Region: PRK15447 484021014853 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 484021014854 hypothetical protein; Provisional; Region: PRK10508 484021014855 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 484021014856 tryptophan permease; Provisional; Region: PRK10483 484021014857 aromatic amino acid transport protein; Region: araaP; TIGR00837 484021014858 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 484021014859 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 484021014860 ATP binding site [chemical binding]; other site 484021014861 Mg++ binding site [ion binding]; other site 484021014862 motif III; other site 484021014863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021014864 nucleotide binding region [chemical binding]; other site 484021014865 ATP-binding site [chemical binding]; other site 484021014866 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 484021014867 putative RNA binding site [nucleotide binding]; other site 484021014868 lipoprotein NlpI; Provisional; Region: PRK11189 484021014869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021014870 binding surface 484021014871 TPR motif; other site 484021014872 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 484021014873 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 484021014874 RNase E interface [polypeptide binding]; other site 484021014875 trimer interface [polypeptide binding]; other site 484021014876 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 484021014877 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 484021014878 RNase E interface [polypeptide binding]; other site 484021014879 trimer interface [polypeptide binding]; other site 484021014880 active site 484021014881 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 484021014882 putative nucleic acid binding region [nucleotide binding]; other site 484021014883 G-X-X-G motif; other site 484021014884 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 484021014885 RNA binding site [nucleotide binding]; other site 484021014886 domain interface; other site 484021014887 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 484021014888 16S/18S rRNA binding site [nucleotide binding]; other site 484021014889 S13e-L30e interaction site [polypeptide binding]; other site 484021014890 25S rRNA binding site [nucleotide binding]; other site 484021014891 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 484021014892 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 484021014893 RNA binding site [nucleotide binding]; other site 484021014894 active site 484021014895 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 484021014896 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 484021014897 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484021014898 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 484021014899 translation initiation factor IF-2; Region: IF-2; TIGR00487 484021014900 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484021014901 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 484021014902 G1 box; other site 484021014903 putative GEF interaction site [polypeptide binding]; other site 484021014904 GTP/Mg2+ binding site [chemical binding]; other site 484021014905 Switch I region; other site 484021014906 G2 box; other site 484021014907 G3 box; other site 484021014908 Switch II region; other site 484021014909 G4 box; other site 484021014910 G5 box; other site 484021014911 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 484021014912 Translation-initiation factor 2; Region: IF-2; pfam11987 484021014913 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 484021014914 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 484021014915 NusA N-terminal domain; Region: NusA_N; pfam08529 484021014916 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 484021014917 RNA binding site [nucleotide binding]; other site 484021014918 homodimer interface [polypeptide binding]; other site 484021014919 NusA-like KH domain; Region: KH_5; pfam13184 484021014920 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 484021014921 G-X-X-G motif; other site 484021014922 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 484021014923 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 484021014924 ribosome maturation protein RimP; Reviewed; Region: PRK00092 484021014925 Sm and related proteins; Region: Sm_like; cl00259 484021014926 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 484021014927 putative oligomer interface [polypeptide binding]; other site 484021014928 putative RNA binding site [nucleotide binding]; other site 484021014929 argininosuccinate synthase; Validated; Region: PRK05370 484021014930 argininosuccinate synthase; Provisional; Region: PRK13820 484021014931 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 484021014932 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 484021014933 YfaZ precursor; Region: YfaZ; pfam07437 484021014934 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 484021014935 Preprotein translocase SecG subunit; Region: SecG; pfam03840 484021014936 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 484021014937 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 484021014938 active site 484021014939 substrate binding site [chemical binding]; other site 484021014940 metal binding site [ion binding]; metal-binding site 484021014941 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 484021014942 dihydropteroate synthase; Region: DHPS; TIGR01496 484021014943 substrate binding pocket [chemical binding]; other site 484021014944 dimer interface [polypeptide binding]; other site 484021014945 inhibitor binding site; inhibition site 484021014946 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 484021014947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021014948 Walker A motif; other site 484021014949 ATP binding site [chemical binding]; other site 484021014950 Walker B motif; other site 484021014951 arginine finger; other site 484021014952 Peptidase family M41; Region: Peptidase_M41; pfam01434 484021014953 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 484021014954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021014955 S-adenosylmethionine binding site [chemical binding]; other site 484021014956 RNA-binding protein YhbY; Provisional; Region: PRK10343 484021014957 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 484021014958 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 484021014959 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 484021014960 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 484021014961 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 484021014962 GTPase CgtA; Reviewed; Region: obgE; PRK12298 484021014963 GTP1/OBG; Region: GTP1_OBG; pfam01018 484021014964 Obg GTPase; Region: Obg; cd01898 484021014965 G1 box; other site 484021014966 GTP/Mg2+ binding site [chemical binding]; other site 484021014967 Switch I region; other site 484021014968 G2 box; other site 484021014969 G3 box; other site 484021014970 Switch II region; other site 484021014971 G4 box; other site 484021014972 G5 box; other site 484021014973 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484021014974 EamA-like transporter family; Region: EamA; pfam00892 484021014975 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 484021014976 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 484021014977 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 484021014978 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 484021014979 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484021014980 substrate binding pocket [chemical binding]; other site 484021014981 chain length determination region; other site 484021014982 substrate-Mg2+ binding site; other site 484021014983 catalytic residues [active] 484021014984 aspartate-rich region 1; other site 484021014985 active site lid residues [active] 484021014986 aspartate-rich region 2; other site 484021014987 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 484021014988 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 484021014989 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 484021014990 hinge; other site 484021014991 active site 484021014992 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 484021014993 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 484021014994 anti sigma factor interaction site; other site 484021014995 regulatory phosphorylation site [posttranslational modification]; other site 484021014996 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 484021014997 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 484021014998 mce related protein; Region: MCE; pfam02470 484021014999 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 484021015000 conserved hypothetical integral membrane protein; Region: TIGR00056 484021015001 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 484021015002 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 484021015003 Walker A/P-loop; other site 484021015004 ATP binding site [chemical binding]; other site 484021015005 Q-loop/lid; other site 484021015006 ABC transporter signature motif; other site 484021015007 Walker B; other site 484021015008 D-loop; other site 484021015009 H-loop/switch region; other site 484021015010 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 484021015011 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 484021015012 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 484021015013 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 484021015014 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 484021015015 putative active site [active] 484021015016 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 484021015017 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 484021015018 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 484021015019 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 484021015020 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 484021015021 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 484021015022 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 484021015023 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 484021015024 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 484021015025 Walker A/P-loop; other site 484021015026 ATP binding site [chemical binding]; other site 484021015027 Q-loop/lid; other site 484021015028 ABC transporter signature motif; other site 484021015029 Walker B; other site 484021015030 D-loop; other site 484021015031 H-loop/switch region; other site 484021015032 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 484021015033 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 484021015034 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 484021015035 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 484021015036 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 484021015037 30S subunit binding site; other site 484021015038 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021015039 active site 484021015040 phosphorylation site [posttranslational modification] 484021015041 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 484021015042 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484021015043 dimerization domain swap beta strand [polypeptide binding]; other site 484021015044 regulatory protein interface [polypeptide binding]; other site 484021015045 active site 484021015046 regulatory phosphorylation site [posttranslational modification]; other site 484021015047 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 484021015048 Transglycosylase; Region: Transgly; cl17702 484021015049 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 484021015050 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 484021015051 conserved cys residue [active] 484021015052 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 484021015053 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 484021015054 putative active site [active] 484021015055 heme pocket [chemical binding]; other site 484021015056 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021015057 dimer interface [polypeptide binding]; other site 484021015058 phosphorylation site [posttranslational modification] 484021015059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021015060 ATP binding site [chemical binding]; other site 484021015061 Mg2+ binding site [ion binding]; other site 484021015062 G-X-G motif; other site 484021015063 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021015064 active site 484021015065 phosphorylation site [posttranslational modification] 484021015066 intermolecular recognition site; other site 484021015067 dimerization interface [polypeptide binding]; other site 484021015068 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 484021015069 putative binding surface; other site 484021015070 active site 484021015071 mannonate dehydratase; Provisional; Region: PRK03906 484021015072 mannonate dehydratase; Region: uxuA; TIGR00695 484021015073 putative oxidoreductase; Provisional; Region: PRK10083 484021015074 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 484021015075 putative NAD(P) binding site [chemical binding]; other site 484021015076 catalytic Zn binding site [ion binding]; other site 484021015077 structural Zn binding site [ion binding]; other site 484021015078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021015079 D-galactonate transporter; Region: 2A0114; TIGR00893 484021015080 putative substrate translocation pore; other site 484021015081 radical SAM protein, TIGR01212 family; Region: TIGR01212 484021015082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484021015083 FeS/SAM binding site; other site 484021015084 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 484021015085 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 484021015086 active site 484021015087 dimer interface [polypeptide binding]; other site 484021015088 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 484021015089 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 484021015090 active site 484021015091 FMN binding site [chemical binding]; other site 484021015092 substrate binding site [chemical binding]; other site 484021015093 3Fe-4S cluster binding site [ion binding]; other site 484021015094 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 484021015095 domain interface; other site 484021015096 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 484021015097 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 484021015098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021015099 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021015100 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 484021015101 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 484021015102 putative active site cavity [active] 484021015103 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 484021015104 stringent starvation protein A; Provisional; Region: sspA; PRK09481 484021015105 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 484021015106 C-terminal domain interface [polypeptide binding]; other site 484021015107 putative GSH binding site (G-site) [chemical binding]; other site 484021015108 dimer interface [polypeptide binding]; other site 484021015109 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 484021015110 dimer interface [polypeptide binding]; other site 484021015111 N-terminal domain interface [polypeptide binding]; other site 484021015112 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 484021015113 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 484021015114 23S rRNA interface [nucleotide binding]; other site 484021015115 L3 interface [polypeptide binding]; other site 484021015116 Predicted ATPase [General function prediction only]; Region: COG1485 484021015117 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 484021015118 hypothetical protein; Provisional; Region: PRK11677 484021015119 serine endoprotease; Provisional; Region: PRK10139 484021015120 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 484021015121 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 484021015122 protein binding site [polypeptide binding]; other site 484021015123 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 484021015124 serine endoprotease; Provisional; Region: PRK10898 484021015125 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 484021015126 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 484021015127 protein binding site [polypeptide binding]; other site 484021015128 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 484021015129 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 484021015130 oxaloacetate decarboxylase; Provisional; Region: PRK14040 484021015131 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 484021015132 active site 484021015133 catalytic residues [active] 484021015134 metal binding site [ion binding]; metal-binding site 484021015135 homodimer binding site [polypeptide binding]; other site 484021015136 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 484021015137 carboxyltransferase (CT) interaction site; other site 484021015138 biotinylation site [posttranslational modification]; other site 484021015139 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 484021015140 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 484021015141 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 484021015142 Citrate transporter; Region: CitMHS; pfam03600 484021015143 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 484021015144 transmembrane helices; other site 484021015145 Transcriptional regulators [Transcription]; Region: GntR; COG1802 484021015146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021015147 DNA-binding site [nucleotide binding]; DNA binding site 484021015148 FCD domain; Region: FCD; pfam07729 484021015149 Transcriptional regulators [Transcription]; Region: GntR; COG1802 484021015150 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021015151 DNA-binding site [nucleotide binding]; DNA binding site 484021015152 malate dehydrogenase; Provisional; Region: PRK05086 484021015153 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 484021015154 NAD binding site [chemical binding]; other site 484021015155 dimerization interface [polypeptide binding]; other site 484021015156 Substrate binding site [chemical binding]; other site 484021015157 arginine repressor; Provisional; Region: PRK05066 484021015158 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 484021015159 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 484021015160 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021015161 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021015162 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 484021015163 RNAase interaction site [polypeptide binding]; other site 484021015164 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 484021015165 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484021015166 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 484021015167 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 484021015168 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021015169 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021015170 efflux system membrane protein; Provisional; Region: PRK11594 484021015171 transcriptional regulator; Provisional; Region: PRK10632 484021015172 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021015173 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 484021015174 putative effector binding pocket; other site 484021015175 dimerization interface [polypeptide binding]; other site 484021015176 protease TldD; Provisional; Region: tldD; PRK10735 484021015177 hypothetical protein; Provisional; Region: PRK10899 484021015178 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 484021015179 ribonuclease G; Provisional; Region: PRK11712 484021015180 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484021015181 homodimer interface [polypeptide binding]; other site 484021015182 oligonucleotide binding site [chemical binding]; other site 484021015183 Maf-like protein; Region: Maf; pfam02545 484021015184 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 484021015185 active site 484021015186 dimer interface [polypeptide binding]; other site 484021015187 rod shape-determining protein MreD; Provisional; Region: PRK11060 484021015188 rod shape-determining protein MreC; Region: mreC; TIGR00219 484021015189 rod shape-determining protein MreC; Region: MreC; pfam04085 484021015190 rod shape-determining protein MreB; Provisional; Region: PRK13927 484021015191 MreB and similar proteins; Region: MreB_like; cd10225 484021015192 nucleotide binding site [chemical binding]; other site 484021015193 Mg binding site [ion binding]; other site 484021015194 putative protofilament interaction site [polypeptide binding]; other site 484021015195 RodZ interaction site [polypeptide binding]; other site 484021015196 regulatory protein CsrD; Provisional; Region: PRK11059 484021015197 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021015198 metal binding site [ion binding]; metal-binding site 484021015199 active site 484021015200 I-site; other site 484021015201 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021015202 sensor protein PhoQ; Provisional; Region: PRK10815 484021015203 TMAO/DMSO reductase; Reviewed; Region: PRK05363 484021015204 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 484021015205 Moco binding site; other site 484021015206 metal coordination site [ion binding]; other site 484021015207 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 484021015208 Dehydroquinase class II; Region: DHquinase_II; pfam01220 484021015209 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 484021015210 trimer interface [polypeptide binding]; other site 484021015211 active site 484021015212 dimer interface [polypeptide binding]; other site 484021015213 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 484021015214 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 484021015215 carboxyltransferase (CT) interaction site; other site 484021015216 biotinylation site [posttranslational modification]; other site 484021015217 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 484021015218 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484021015219 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 484021015220 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 484021015221 hypothetical protein; Provisional; Region: PRK10633 484021015222 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 484021015223 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 484021015224 Na binding site [ion binding]; other site 484021015225 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 484021015226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484021015227 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 484021015228 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 484021015229 FMN binding site [chemical binding]; other site 484021015230 active site 484021015231 catalytic residues [active] 484021015232 substrate binding site [chemical binding]; other site 484021015233 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 484021015234 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 484021015235 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 484021015236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021015237 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 484021015238 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 484021015239 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021015240 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021015241 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 484021015242 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 484021015243 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 484021015244 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 484021015245 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 484021015246 trimer interface [polypeptide binding]; other site 484021015247 putative metal binding site [ion binding]; other site 484021015248 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 484021015249 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 484021015250 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484021015251 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484021015252 shikimate binding site; other site 484021015253 NAD(P) binding site [chemical binding]; other site 484021015254 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 484021015255 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484021015256 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 484021015257 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484021015258 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 484021015259 hypothetical protein; Validated; Region: PRK03430 484021015260 hypothetical protein; Provisional; Region: PRK10736 484021015261 DNA protecting protein DprA; Region: dprA; TIGR00732 484021015262 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484021015263 active site 484021015264 catalytic residues [active] 484021015265 metal binding site [ion binding]; metal-binding site 484021015266 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 484021015267 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 484021015268 putative active site [active] 484021015269 substrate binding site [chemical binding]; other site 484021015270 putative cosubstrate binding site; other site 484021015271 catalytic site [active] 484021015272 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 484021015273 substrate binding site [chemical binding]; other site 484021015274 16S rRNA methyltransferase B; Provisional; Region: PRK10901 484021015275 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 484021015276 putative RNA binding site [nucleotide binding]; other site 484021015277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021015278 S-adenosylmethionine binding site [chemical binding]; other site 484021015279 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 484021015280 TrkA-N domain; Region: TrkA_N; pfam02254 484021015281 TrkA-C domain; Region: TrkA_C; pfam02080 484021015282 TrkA-N domain; Region: TrkA_N; pfam02254 484021015283 TrkA-C domain; Region: TrkA_C; pfam02080 484021015284 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 484021015285 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 484021015286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 484021015287 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 484021015288 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 484021015289 DNA binding residues [nucleotide binding] 484021015290 dimer interface [polypeptide binding]; other site 484021015291 metal binding site [ion binding]; metal-binding site 484021015292 hypothetical protein; Provisional; Region: PRK10203 484021015293 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 484021015294 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 484021015295 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 484021015296 alphaNTD homodimer interface [polypeptide binding]; other site 484021015297 alphaNTD - beta interaction site [polypeptide binding]; other site 484021015298 alphaNTD - beta' interaction site [polypeptide binding]; other site 484021015299 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 484021015300 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 484021015301 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 484021015302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021015303 RNA binding surface [nucleotide binding]; other site 484021015304 30S ribosomal protein S11; Validated; Region: PRK05309 484021015305 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 484021015306 30S ribosomal protein S13; Region: bact_S13; TIGR03631 484021015307 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 484021015308 SecY translocase; Region: SecY; pfam00344 484021015309 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 484021015310 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 484021015311 23S rRNA binding site [nucleotide binding]; other site 484021015312 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 484021015313 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 484021015314 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 484021015315 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 484021015316 23S rRNA interface [nucleotide binding]; other site 484021015317 5S rRNA interface [nucleotide binding]; other site 484021015318 L27 interface [polypeptide binding]; other site 484021015319 L5 interface [polypeptide binding]; other site 484021015320 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 484021015321 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484021015322 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484021015323 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 484021015324 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 484021015325 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 484021015326 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 484021015327 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 484021015328 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 484021015329 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 484021015330 RNA binding site [nucleotide binding]; other site 484021015331 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 484021015332 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 484021015333 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 484021015334 23S rRNA interface [nucleotide binding]; other site 484021015335 putative translocon interaction site; other site 484021015336 signal recognition particle (SRP54) interaction site; other site 484021015337 L23 interface [polypeptide binding]; other site 484021015338 trigger factor interaction site; other site 484021015339 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 484021015340 23S rRNA interface [nucleotide binding]; other site 484021015341 5S rRNA interface [nucleotide binding]; other site 484021015342 putative antibiotic binding site [chemical binding]; other site 484021015343 L25 interface [polypeptide binding]; other site 484021015344 L27 interface [polypeptide binding]; other site 484021015345 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 484021015346 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 484021015347 G-X-X-G motif; other site 484021015348 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 484021015349 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 484021015350 protein-rRNA interface [nucleotide binding]; other site 484021015351 putative translocon binding site; other site 484021015352 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 484021015353 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 484021015354 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 484021015355 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 484021015356 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 484021015357 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 484021015358 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 484021015359 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 484021015360 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 484021015361 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 484021015362 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 484021015363 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 484021015364 heme binding site [chemical binding]; other site 484021015365 ferroxidase pore; other site 484021015366 ferroxidase diiron center [ion binding]; other site 484021015367 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 484021015368 elongation factor Tu; Reviewed; Region: PRK00049 484021015369 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 484021015370 G1 box; other site 484021015371 GEF interaction site [polypeptide binding]; other site 484021015372 GTP/Mg2+ binding site [chemical binding]; other site 484021015373 Switch I region; other site 484021015374 G2 box; other site 484021015375 G3 box; other site 484021015376 Switch II region; other site 484021015377 G4 box; other site 484021015378 G5 box; other site 484021015379 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 484021015380 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 484021015381 Antibiotic Binding Site [chemical binding]; other site 484021015382 elongation factor G; Reviewed; Region: PRK00007 484021015383 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 484021015384 G1 box; other site 484021015385 putative GEF interaction site [polypeptide binding]; other site 484021015386 GTP/Mg2+ binding site [chemical binding]; other site 484021015387 Switch I region; other site 484021015388 G2 box; other site 484021015389 G3 box; other site 484021015390 Switch II region; other site 484021015391 G4 box; other site 484021015392 G5 box; other site 484021015393 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 484021015394 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 484021015395 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 484021015396 30S ribosomal protein S7; Validated; Region: PRK05302 484021015397 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 484021015398 S17 interaction site [polypeptide binding]; other site 484021015399 S8 interaction site; other site 484021015400 16S rRNA interaction site [nucleotide binding]; other site 484021015401 streptomycin interaction site [chemical binding]; other site 484021015402 23S rRNA interaction site [nucleotide binding]; other site 484021015403 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 484021015404 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 484021015405 sulfur relay protein TusC; Validated; Region: PRK00211 484021015406 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 484021015407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 484021015408 YheO-like PAS domain; Region: PAS_6; pfam08348 484021015409 HTH domain; Region: HTH_22; pfam13309 484021015410 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 484021015411 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 484021015412 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484021015413 phi X174 lysis protein; Provisional; Region: PRK02793 484021015414 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 484021015415 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484021015416 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 484021015417 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 484021015418 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 484021015419 TrkA-N domain; Region: TrkA_N; pfam02254 484021015420 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 484021015421 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 484021015422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021015423 Walker A/P-loop; other site 484021015424 ATP binding site [chemical binding]; other site 484021015425 Q-loop/lid; other site 484021015426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021015427 ABC transporter signature motif; other site 484021015428 Walker B; other site 484021015429 D-loop; other site 484021015430 ABC transporter; Region: ABC_tran_2; pfam12848 484021015431 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021015432 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 484021015433 putative hydrolase; Provisional; Region: PRK10985 484021015434 hypothetical protein; Provisional; Region: PRK04966 484021015435 phosphoribulokinase; Provisional; Region: PRK15453 484021015436 active site 484021015437 hypothetical protein; Provisional; Region: PRK10738 484021015438 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 484021015439 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 484021015440 ligand binding site [chemical binding]; other site 484021015441 flexible hinge region; other site 484021015442 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 484021015443 putative switch regulator; other site 484021015444 non-specific DNA interactions [nucleotide binding]; other site 484021015445 DNA binding site [nucleotide binding] 484021015446 sequence specific DNA binding site [nucleotide binding]; other site 484021015447 putative cAMP binding site [chemical binding]; other site 484021015448 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 484021015449 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 484021015450 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 484021015451 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 484021015452 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021015453 inhibitor-cofactor binding pocket; inhibition site 484021015454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021015455 catalytic residue [active] 484021015456 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 484021015457 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484021015458 glutamine binding [chemical binding]; other site 484021015459 catalytic triad [active] 484021015460 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 484021015461 cell filamentation protein Fic; Provisional; Region: PRK10347 484021015462 hypothetical protein; Provisional; Region: PRK10204 484021015463 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 484021015464 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 484021015465 substrate binding site [chemical binding]; other site 484021015466 putative transporter; Provisional; Region: PRK03699 484021015467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021015468 putative substrate translocation pore; other site 484021015469 cytosine deaminase; Provisional; Region: PRK09230 484021015470 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 484021015471 active site 484021015472 nitrite reductase subunit NirD; Provisional; Region: PRK14989 484021015473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021015474 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 484021015475 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 484021015476 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 484021015477 siroheme synthase; Provisional; Region: cysG; PRK10637 484021015478 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 484021015479 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 484021015480 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 484021015481 active site 484021015482 SAM binding site [chemical binding]; other site 484021015483 homodimer interface [polypeptide binding]; other site 484021015484 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 484021015485 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 484021015486 active site 484021015487 HIGH motif; other site 484021015488 dimer interface [polypeptide binding]; other site 484021015489 KMSKS motif; other site 484021015490 phosphoglycolate phosphatase; Provisional; Region: PRK13222 484021015491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021015492 motif II; other site 484021015493 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 484021015494 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 484021015495 substrate binding site [chemical binding]; other site 484021015496 hexamer interface [polypeptide binding]; other site 484021015497 metal binding site [ion binding]; metal-binding site 484021015498 DNA adenine methylase; Provisional; Region: PRK10904 484021015499 cell division protein DamX; Validated; Region: PRK10905 484021015500 hypothetical protein; Reviewed; Region: PRK11901 484021015501 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 484021015502 active site 484021015503 dimer interface [polypeptide binding]; other site 484021015504 metal binding site [ion binding]; metal-binding site 484021015505 shikimate kinase; Reviewed; Region: aroK; PRK00131 484021015506 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 484021015507 ADP binding site [chemical binding]; other site 484021015508 magnesium binding site [ion binding]; other site 484021015509 putative shikimate binding site; other site 484021015510 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 484021015511 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 484021015512 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 484021015513 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 484021015514 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 484021015515 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 484021015516 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 484021015517 Transglycosylase; Region: Transgly; pfam00912 484021015518 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 484021015519 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 484021015520 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484021015521 ADP-ribose binding site [chemical binding]; other site 484021015522 dimer interface [polypeptide binding]; other site 484021015523 active site 484021015524 nudix motif; other site 484021015525 metal binding site [ion binding]; metal-binding site 484021015526 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 484021015527 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 484021015528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021015529 motif II; other site 484021015530 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484021015531 RNA binding surface [nucleotide binding]; other site 484021015532 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 484021015533 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 484021015534 dimerization interface [polypeptide binding]; other site 484021015535 domain crossover interface; other site 484021015536 redox-dependent activation switch; other site 484021015537 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 484021015538 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 484021015539 active site 484021015540 substrate-binding site [chemical binding]; other site 484021015541 metal-binding site [ion binding] 484021015542 ATP binding site [chemical binding]; other site 484021015543 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 484021015544 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484021015545 dimerization interface [polypeptide binding]; other site 484021015546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484021015547 dimer interface [polypeptide binding]; other site 484021015548 phosphorylation site [posttranslational modification] 484021015549 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021015550 ATP binding site [chemical binding]; other site 484021015551 Mg2+ binding site [ion binding]; other site 484021015552 G-X-G motif; other site 484021015553 osmolarity response regulator; Provisional; Region: ompR; PRK09468 484021015554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021015555 active site 484021015556 phosphorylation site [posttranslational modification] 484021015557 intermolecular recognition site; other site 484021015558 dimerization interface [polypeptide binding]; other site 484021015559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484021015560 DNA binding site [nucleotide binding] 484021015561 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 484021015562 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 484021015563 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 484021015564 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 484021015565 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 484021015566 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 484021015567 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 484021015568 RNA binding site [nucleotide binding]; other site 484021015569 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 484021015570 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 484021015571 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 484021015572 G1 box; other site 484021015573 GTP/Mg2+ binding site [chemical binding]; other site 484021015574 Switch I region; other site 484021015575 G2 box; other site 484021015576 G3 box; other site 484021015577 Switch II region; other site 484021015578 G4 box; other site 484021015579 G5 box; other site 484021015580 Nucleoside recognition; Region: Gate; pfam07670 484021015581 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 484021015582 Nucleoside recognition; Region: Gate; pfam07670 484021015583 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 484021015584 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 484021015585 carboxylesterase BioH; Provisional; Region: PRK10349 484021015586 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 484021015587 catalytic site [active] 484021015588 DNA utilization protein GntX; Provisional; Region: PRK11595 484021015589 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021015590 active site 484021015591 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 484021015592 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 484021015593 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 484021015594 high-affinity gluconate transporter; Provisional; Region: PRK14984 484021015595 gluconate transporter; Region: gntP; TIGR00791 484021015596 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 484021015597 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 484021015598 maltodextrin phosphorylase; Provisional; Region: PRK14985 484021015599 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 484021015600 homodimer interface [polypeptide binding]; other site 484021015601 active site pocket [active] 484021015602 transcriptional regulator MalT; Provisional; Region: PRK04841 484021015603 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021015604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021015605 DNA binding residues [nucleotide binding] 484021015606 dimerization interface [polypeptide binding]; other site 484021015607 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 484021015608 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 484021015609 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484021015610 intramembrane serine protease GlpG; Provisional; Region: PRK10907 484021015611 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 484021015612 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 484021015613 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 484021015614 active site residue [active] 484021015615 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 484021015616 glycogen phosphorylase; Provisional; Region: PRK14986 484021015617 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 484021015618 homodimer interface [polypeptide binding]; other site 484021015619 active site pocket [active] 484021015620 glycogen synthase; Provisional; Region: glgA; PRK00654 484021015621 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 484021015622 ADP-binding pocket [chemical binding]; other site 484021015623 homodimer interface [polypeptide binding]; other site 484021015624 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 484021015625 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 484021015626 ligand binding site; other site 484021015627 oligomer interface; other site 484021015628 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 484021015629 dimer interface [polypeptide binding]; other site 484021015630 N-terminal domain interface [polypeptide binding]; other site 484021015631 sulfate 1 binding site; other site 484021015632 glycogen debranching enzyme; Provisional; Region: PRK03705 484021015633 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 484021015634 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 484021015635 active site 484021015636 catalytic site [active] 484021015637 glycogen branching enzyme; Provisional; Region: PRK05402 484021015638 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 484021015639 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 484021015640 active site 484021015641 catalytic site [active] 484021015642 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 484021015643 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 484021015644 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484021015645 low affinity gluconate transporter; Provisional; Region: PRK10472 484021015646 gluconate transporter; Region: gntP; TIGR00791 484021015647 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 484021015648 ATP-binding site [chemical binding]; other site 484021015649 Gluconate-6-phosphate binding site [chemical binding]; other site 484021015650 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 484021015651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021015652 DNA binding site [nucleotide binding] 484021015653 domain linker motif; other site 484021015654 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 484021015655 putative ligand binding site [chemical binding]; other site 484021015656 putative dimerization interface [polypeptide binding]; other site 484021015657 Pirin-related protein [General function prediction only]; Region: COG1741 484021015658 Pirin; Region: Pirin; pfam02678 484021015659 putative oxidoreductase; Provisional; Region: PRK10206 484021015660 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484021015661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484021015662 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 484021015663 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 484021015664 putative acetyltransferase YhhY; Provisional; Region: PRK10140 484021015665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021015666 Coenzyme A binding pocket [chemical binding]; other site 484021015667 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 484021015668 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 484021015669 Protein of unknown function (DUF2756); Region: DUF2756; pfam10956 484021015670 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 484021015671 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 484021015672 putative active site [active] 484021015673 catalytic site [active] 484021015674 putative metal binding site [ion binding]; other site 484021015675 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 484021015676 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 484021015677 Walker A/P-loop; other site 484021015678 ATP binding site [chemical binding]; other site 484021015679 Q-loop/lid; other site 484021015680 ABC transporter signature motif; other site 484021015681 Walker B; other site 484021015682 D-loop; other site 484021015683 H-loop/switch region; other site 484021015684 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484021015685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021015686 dimer interface [polypeptide binding]; other site 484021015687 conserved gate region; other site 484021015688 putative PBP binding loops; other site 484021015689 ABC-ATPase subunit interface; other site 484021015690 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 484021015691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021015692 dimer interface [polypeptide binding]; other site 484021015693 conserved gate region; other site 484021015694 putative PBP binding loops; other site 484021015695 ABC-ATPase subunit interface; other site 484021015696 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 484021015697 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 484021015698 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 484021015699 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 484021015700 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 484021015701 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 484021015702 Walker A/P-loop; other site 484021015703 ATP binding site [chemical binding]; other site 484021015704 Q-loop/lid; other site 484021015705 ABC transporter signature motif; other site 484021015706 Walker B; other site 484021015707 D-loop; other site 484021015708 H-loop/switch region; other site 484021015709 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 484021015710 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 484021015711 Walker A/P-loop; other site 484021015712 ATP binding site [chemical binding]; other site 484021015713 Q-loop/lid; other site 484021015714 ABC transporter signature motif; other site 484021015715 Walker B; other site 484021015716 D-loop; other site 484021015717 H-loop/switch region; other site 484021015718 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 484021015719 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 484021015720 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 484021015721 TM-ABC transporter signature motif; other site 484021015722 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021015723 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 484021015724 TM-ABC transporter signature motif; other site 484021015725 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 484021015726 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 484021015727 dimerization interface [polypeptide binding]; other site 484021015728 ligand binding site [chemical binding]; other site 484021015729 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 484021015730 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 484021015731 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 484021015732 dimerization interface [polypeptide binding]; other site 484021015733 ligand binding site [chemical binding]; other site 484021015734 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 484021015735 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484021015736 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 484021015737 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484021015738 inhibitor-cofactor binding pocket; inhibition site 484021015739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021015740 catalytic residue [active] 484021015741 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484021015742 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021015743 DNA-binding site [nucleotide binding]; DNA binding site 484021015744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021015745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021015746 homodimer interface [polypeptide binding]; other site 484021015747 catalytic residue [active] 484021015748 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 484021015749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484021015750 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484021015751 DNA binding residues [nucleotide binding] 484021015752 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 484021015753 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 484021015754 cell division protein FtsE; Provisional; Region: PRK10908 484021015755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021015756 Walker A/P-loop; other site 484021015757 ATP binding site [chemical binding]; other site 484021015758 Q-loop/lid; other site 484021015759 ABC transporter signature motif; other site 484021015760 Walker B; other site 484021015761 D-loop; other site 484021015762 H-loop/switch region; other site 484021015763 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 484021015764 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 484021015765 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484021015766 P loop; other site 484021015767 GTP binding site [chemical binding]; other site 484021015768 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 484021015769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021015770 S-adenosylmethionine binding site [chemical binding]; other site 484021015771 hypothetical protein; Provisional; Region: PRK10910 484021015772 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 484021015773 Predicted membrane protein [Function unknown]; Region: COG3714 484021015774 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 484021015775 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 484021015776 metal-binding site [ion binding] 484021015777 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484021015778 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 484021015779 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 484021015780 CPxP motif; other site 484021015781 hypothetical protein; Provisional; Region: PRK11212 484021015782 hypothetical protein; Provisional; Region: PRK11615 484021015783 major facilitator superfamily transporter; Provisional; Region: PRK05122 484021015784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021015785 putative substrate translocation pore; other site 484021015786 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 484021015787 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484021015788 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 484021015789 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 484021015790 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 484021015791 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 484021015792 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 484021015793 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 484021015794 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 484021015795 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 484021015796 substrate binding site [chemical binding]; other site 484021015797 cosubstrate binding site; other site 484021015798 catalytic site [active] 484021015799 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 484021015800 active site 484021015801 hexamer interface [polypeptide binding]; other site 484021015802 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 484021015803 NAD binding site [chemical binding]; other site 484021015804 substrate binding site [chemical binding]; other site 484021015805 active site 484021015806 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 484021015807 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 484021015808 Ligand binding site; other site 484021015809 Putative Catalytic site; other site 484021015810 DXD motif; other site 484021015811 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 484021015812 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 484021015813 inhibitor-cofactor binding pocket; inhibition site 484021015814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021015815 catalytic residue [active] 484021015816 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 484021015817 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021015818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021015819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484021015820 dimerization interface [polypeptide binding]; other site 484021015821 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 484021015822 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021015823 substrate binding site [chemical binding]; other site 484021015824 nickel transporter permease NikB; Provisional; Region: PRK10352 484021015825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021015826 dimer interface [polypeptide binding]; other site 484021015827 conserved gate region; other site 484021015828 putative PBP binding loops; other site 484021015829 ABC-ATPase subunit interface; other site 484021015830 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 484021015831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021015832 dimer interface [polypeptide binding]; other site 484021015833 conserved gate region; other site 484021015834 putative PBP binding loops; other site 484021015835 ABC-ATPase subunit interface; other site 484021015836 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 484021015837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021015838 Walker A/P-loop; other site 484021015839 ATP binding site [chemical binding]; other site 484021015840 Q-loop/lid; other site 484021015841 ABC transporter signature motif; other site 484021015842 Walker B; other site 484021015843 D-loop; other site 484021015844 H-loop/switch region; other site 484021015845 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 484021015846 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021015847 Walker A/P-loop; other site 484021015848 ATP binding site [chemical binding]; other site 484021015849 Q-loop/lid; other site 484021015850 ABC transporter signature motif; other site 484021015851 Walker B; other site 484021015852 D-loop; other site 484021015853 H-loop/switch region; other site 484021015854 nickel responsive regulator; Provisional; Region: PRK02967 484021015855 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 484021015856 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 484021015857 HicB family; Region: HicB; pfam05534 484021015858 FOG: CBS domain [General function prediction only]; Region: COG0517 484021015859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 484021015860 Divalent cation transporter; Region: MgtE; pfam01769 484021015861 Predicted flavoproteins [General function prediction only]; Region: COG2081 484021015862 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021015863 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 484021015864 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 484021015865 universal stress protein UspB; Provisional; Region: PRK04960 484021015866 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484021015867 Ligand Binding Site [chemical binding]; other site 484021015868 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 484021015869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021015870 putative substrate translocation pore; other site 484021015871 POT family; Region: PTR2; pfam00854 484021015872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021015873 S-adenosylmethionine binding site [chemical binding]; other site 484021015874 oligopeptidase A; Provisional; Region: PRK10911 484021015875 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 484021015876 active site 484021015877 Zn binding site [ion binding]; other site 484021015878 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 484021015879 active site 484021015880 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484021015881 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 484021015882 glutathione reductase; Validated; Region: PRK06116 484021015883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484021015884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484021015885 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484021015886 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 484021015887 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484021015888 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 484021015889 putative N-terminal domain interface [polypeptide binding]; other site 484021015890 putative dimer interface [polypeptide binding]; other site 484021015891 putative substrate binding pocket (H-site) [chemical binding]; other site 484021015892 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 484021015893 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 484021015894 putative active site [active] 484021015895 metal binding site [ion binding]; metal-binding site 484021015896 trehalase; Provisional; Region: treF; PRK13270 484021015897 Trehalase; Region: Trehalase; pfam01204 484021015898 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484021015899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484021015900 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 484021015901 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484021015902 NAD(P) binding site [chemical binding]; other site 484021015903 active site 484021015904 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021015905 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021015906 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 484021015907 putative effector binding pocket; other site 484021015908 putative dimerization interface [polypeptide binding]; other site 484021015909 inner membrane protein YhjD; Region: TIGR00766 484021015910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021015911 metabolite-proton symporter; Region: 2A0106; TIGR00883 484021015912 putative substrate translocation pore; other site 484021015913 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 484021015914 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 484021015915 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021015916 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484021015917 substrate binding site [chemical binding]; other site 484021015918 ATP binding site [chemical binding]; other site 484021015919 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 484021015920 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 484021015921 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 484021015922 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484021015923 putative diguanylate cyclase; Provisional; Region: PRK13561 484021015924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 484021015925 dimerization interface [polypeptide binding]; other site 484021015926 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 484021015927 metal binding site [ion binding]; metal-binding site 484021015928 active site 484021015929 I-site; other site 484021015930 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 484021015931 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 484021015932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021015933 TPR motif; other site 484021015934 binding surface 484021015935 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021015936 binding surface 484021015937 TPR motif; other site 484021015938 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 484021015939 binding surface 484021015940 TPR motif; other site 484021015941 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 484021015942 endo-1,4-D-glucanase; Provisional; Region: PRK11097 484021015943 cellulose synthase regulator protein; Provisional; Region: PRK11114 484021015944 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 484021015945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484021015946 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 484021015947 DXD motif; other site 484021015948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484021015949 PilZ domain; Region: PilZ; pfam07238 484021015950 cell division protein; Provisional; Region: PRK10037 484021015951 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484021015952 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 484021015953 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 484021015954 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 484021015955 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 484021015956 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 484021015957 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 484021015958 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 484021015959 potential frameshift: common BLAST hit: gi|152972399|ref|YP_001337545.1| putative cellulose synthase 484021015960 Tetratricopeptide repeat; Region: TPR_14; pfam13428 484021015961 TPR repeat; Region: TPR_11; pfam13414 484021015962 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 484021015963 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 484021015964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484021015965 TPR motif; other site 484021015966 cellulose synthase regulator protein; Provisional; Region: PRK11114 484021015967 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 484021015968 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484021015969 DXD motif; other site 484021015970 PilZ domain; Region: PilZ; pfam07238 484021015971 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 484021015972 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484021015973 P-loop; other site 484021015974 Magnesium ion binding site [ion binding]; other site 484021015975 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 484021015976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021015977 Walker A/P-loop; other site 484021015978 ATP binding site [chemical binding]; other site 484021015979 Q-loop/lid; other site 484021015980 ABC transporter signature motif; other site 484021015981 Walker B; other site 484021015982 D-loop; other site 484021015983 H-loop/switch region; other site 484021015984 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 484021015985 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 484021015986 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484021015987 Walker A/P-loop; other site 484021015988 ATP binding site [chemical binding]; other site 484021015989 Q-loop/lid; other site 484021015990 ABC transporter signature motif; other site 484021015991 Walker B; other site 484021015992 D-loop; other site 484021015993 H-loop/switch region; other site 484021015994 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 484021015995 dipeptide transporter; Provisional; Region: PRK10913 484021015996 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484021015997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021015998 dimer interface [polypeptide binding]; other site 484021015999 conserved gate region; other site 484021016000 putative PBP binding loops; other site 484021016001 ABC-ATPase subunit interface; other site 484021016002 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484021016003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021016004 dimer interface [polypeptide binding]; other site 484021016005 conserved gate region; other site 484021016006 putative PBP binding loops; other site 484021016007 ABC-ATPase subunit interface; other site 484021016008 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484021016009 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 484021016010 peptide binding site [polypeptide binding]; other site 484021016011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484021016012 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021016013 Helix-turn-helix domain; Region: HTH_28; pfam13518 484021016014 putative transposase OrfB; Reviewed; Region: PHA02517 484021016015 HTH-like domain; Region: HTH_21; pfam13276 484021016016 Integrase core domain; Region: rve; pfam00665 484021016017 Integrase core domain; Region: rve_2; pfam13333 484021016018 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 484021016019 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 484021016020 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 484021016021 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 484021016022 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 484021016023 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 484021016024 phosphoethanolamine transferase; Provisional; Region: PRK11560 484021016025 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 484021016026 Sulfatase; Region: Sulfatase; pfam00884 484021016027 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 484021016028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016029 putative substrate translocation pore; other site 484021016030 Autotransporter beta-domain; Region: Autotransporter; cl17461 484021016031 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 484021016032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021016033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021016034 Coenzyme A binding pocket [chemical binding]; other site 484021016035 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 484021016036 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 484021016037 molybdopterin cofactor binding site [chemical binding]; other site 484021016038 substrate binding site [chemical binding]; other site 484021016039 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 484021016040 molybdopterin cofactor binding site; other site 484021016041 putative outer membrane lipoprotein; Provisional; Region: PRK10510 484021016042 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 484021016043 ligand binding site [chemical binding]; other site 484021016044 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021016045 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021016046 DNA binding site [nucleotide binding] 484021016047 domain linker motif; other site 484021016048 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 484021016049 putative dimerization interface [polypeptide binding]; other site 484021016050 putative ligand binding site [chemical binding]; other site 484021016051 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 484021016052 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484021016053 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 484021016054 substrate binding site [chemical binding]; other site 484021016055 ATP binding site [chemical binding]; other site 484021016056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016057 D-galactonate transporter; Region: 2A0114; TIGR00893 484021016058 putative substrate translocation pore; other site 484021016059 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 484021016060 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 484021016061 dimerization interface [polypeptide binding]; other site 484021016062 ligand binding site [chemical binding]; other site 484021016063 NADP binding site [chemical binding]; other site 484021016064 catalytic site [active] 484021016065 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 484021016066 benzoate transport; Region: 2A0115; TIGR00895 484021016067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016068 putative substrate translocation pore; other site 484021016069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016070 Predicted transcriptional regulator [Transcription]; Region: COG2944 484021016071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021016072 salt bridge; other site 484021016073 non-specific DNA binding site [nucleotide binding]; other site 484021016074 sequence-specific DNA binding site [nucleotide binding]; other site 484021016075 potential protein location (conserved hypothetical protein) that overlaps protein (cold shock protein) 484021016076 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484021016077 DNA-binding site [nucleotide binding]; DNA binding site 484021016078 RNA-binding motif; other site 484021016079 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 484021016080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021016081 Walker A/P-loop; other site 484021016082 ATP binding site [chemical binding]; other site 484021016083 Q-loop/lid; other site 484021016084 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021016085 ABC transporter signature motif; other site 484021016086 Walker B; other site 484021016087 D-loop; other site 484021016088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484021016089 small toxic polypeptide; Provisional; Region: PRK09759 484021016090 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 484021016091 DALR anticodon binding domain; Region: DALR_1; pfam05746 484021016092 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 484021016093 dimer interface [polypeptide binding]; other site 484021016094 motif 1; other site 484021016095 active site 484021016096 motif 2; other site 484021016097 motif 3; other site 484021016098 YsaB-like lipoprotein; Region: YsaB; pfam13983 484021016099 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 484021016100 Acyltransferase family; Region: Acyl_transf_3; pfam01757 484021016101 hypothetical protein; Provisional; Region: PRK11383 484021016102 yiaA/B two helix domain; Region: YiaAB; pfam05360 484021016103 yiaA/B two helix domain; Region: YiaAB; pfam05360 484021016104 hypothetical protein; Provisional; Region: PRK11403 484021016105 yiaA/B two helix domain; Region: YiaAB; cl01759 484021016106 xylulokinase; Provisional; Region: PRK15027 484021016107 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 484021016108 N- and C-terminal domain interface [polypeptide binding]; other site 484021016109 active site 484021016110 MgATP binding site [chemical binding]; other site 484021016111 catalytic site [active] 484021016112 metal binding site [ion binding]; metal-binding site 484021016113 xylulose binding site [chemical binding]; other site 484021016114 homodimer interface [polypeptide binding]; other site 484021016115 xylose isomerase; Provisional; Region: PRK05474 484021016116 xylose isomerase; Region: xylose_isom_A; TIGR02630 484021016117 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 484021016118 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 484021016119 putative ligand binding site [chemical binding]; other site 484021016120 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 484021016121 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 484021016122 Walker A/P-loop; other site 484021016123 ATP binding site [chemical binding]; other site 484021016124 Q-loop/lid; other site 484021016125 ABC transporter signature motif; other site 484021016126 Walker B; other site 484021016127 D-loop; other site 484021016128 H-loop/switch region; other site 484021016129 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 484021016130 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 484021016131 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 484021016132 TM-ABC transporter signature motif; other site 484021016133 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 484021016134 putative dimerization interface [polypeptide binding]; other site 484021016135 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021016136 putative ligand binding site [chemical binding]; other site 484021016137 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021016138 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021016139 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021016140 hypothetical protein; Provisional; Region: PRK10356 484021016141 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 484021016142 alpha-amylase; Reviewed; Region: malS; PRK09505 484021016143 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 484021016144 active site 484021016145 catalytic site [active] 484021016146 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 484021016147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484021016148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021016149 homodimer interface [polypeptide binding]; other site 484021016150 catalytic residue [active] 484021016151 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 484021016152 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 484021016153 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 484021016154 G1 box; other site 484021016155 putative GEF interaction site [polypeptide binding]; other site 484021016156 GTP/Mg2+ binding site [chemical binding]; other site 484021016157 Switch I region; other site 484021016158 G2 box; other site 484021016159 G3 box; other site 484021016160 Switch II region; other site 484021016161 G4 box; other site 484021016162 G5 box; other site 484021016163 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 484021016164 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 484021016165 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 484021016166 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 484021016167 selenocysteine synthase; Provisional; Region: PRK04311 484021016168 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 484021016169 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 484021016170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021016171 catalytic residue [active] 484021016172 putative glutathione S-transferase; Provisional; Region: PRK10357 484021016173 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 484021016174 putative C-terminal domain interface [polypeptide binding]; other site 484021016175 putative GSH binding site (G-site) [chemical binding]; other site 484021016176 putative dimer interface [polypeptide binding]; other site 484021016177 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 484021016178 dimer interface [polypeptide binding]; other site 484021016179 N-terminal domain interface [polypeptide binding]; other site 484021016180 putative substrate binding pocket (H-site) [chemical binding]; other site 484021016181 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 484021016182 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 484021016183 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 484021016184 active site 484021016185 P-loop; other site 484021016186 phosphorylation site [posttranslational modification] 484021016187 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484021016188 active site 484021016189 phosphorylation site [posttranslational modification] 484021016190 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 484021016191 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 484021016192 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 484021016193 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 484021016194 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 484021016195 Glycogen synthesis protein; Region: GlgS; cl11663 484021016196 hypothetical protein; Provisional; Region: PRK11020 484021016197 L-lactate permease; Provisional; Region: PRK10420 484021016198 glycolate transporter; Provisional; Region: PRK09695 484021016199 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 484021016200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021016201 DNA-binding site [nucleotide binding]; DNA binding site 484021016202 FCD domain; Region: FCD; pfam07729 484021016203 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 484021016204 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 484021016205 active site 484021016206 substrate binding site [chemical binding]; other site 484021016207 FMN binding site [chemical binding]; other site 484021016208 putative catalytic residues [active] 484021016209 putative rRNA methylase; Provisional; Region: PRK10358 484021016210 serine acetyltransferase; Provisional; Region: cysE; PRK11132 484021016211 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 484021016212 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 484021016213 trimer interface [polypeptide binding]; other site 484021016214 active site 484021016215 substrate binding site [chemical binding]; other site 484021016216 CoA binding site [chemical binding]; other site 484021016217 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 484021016218 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 484021016219 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 484021016220 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 484021016221 SecA binding site; other site 484021016222 Preprotein binding site; other site 484021016223 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 484021016224 GSH binding site [chemical binding]; other site 484021016225 catalytic residues [active] 484021016226 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484021016227 active site residue [active] 484021016228 phosphoglyceromutase; Provisional; Region: PRK05434 484021016229 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 484021016230 AmiB activator; Provisional; Region: PRK11637 484021016231 Vps51/Vps67; Region: Vps51; pfam08700 484021016232 Peptidase family M23; Region: Peptidase_M23; pfam01551 484021016233 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 484021016234 NodB motif; other site 484021016235 putative active site [active] 484021016236 putative catalytic site [active] 484021016237 Zn binding site [ion binding]; other site 484021016238 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484021016239 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 484021016240 putative metal binding site; other site 484021016241 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 484021016242 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 484021016243 NAD(P) binding site [chemical binding]; other site 484021016244 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 484021016245 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 484021016246 substrate-cofactor binding pocket; other site 484021016247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484021016248 catalytic residue [active] 484021016249 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 484021016250 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 484021016251 NADP binding site [chemical binding]; other site 484021016252 homopentamer interface [polypeptide binding]; other site 484021016253 substrate binding site [chemical binding]; other site 484021016254 active site 484021016255 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 484021016256 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 484021016257 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 484021016258 putative active site [active] 484021016259 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 484021016260 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 484021016261 putative active site [active] 484021016262 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 484021016263 O-Antigen ligase; Region: Wzy_C; pfam04932 484021016264 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 484021016265 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484021016266 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 484021016267 putative active site [active] 484021016268 putative catalytic site [active] 484021016269 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 484021016270 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 484021016271 putative active site [active] 484021016272 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484021016273 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484021016274 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484021016275 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 484021016276 putative ADP-binding pocket [chemical binding]; other site 484021016277 putative glycosyl transferase; Provisional; Region: PRK10073 484021016278 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484021016279 active site 484021016280 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 484021016281 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 484021016282 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484021016283 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484021016284 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 484021016285 putative metal binding site; other site 484021016286 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 484021016287 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 484021016288 active site 484021016289 (T/H)XGH motif; other site 484021016290 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 484021016291 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 484021016292 DNA binding site [nucleotide binding] 484021016293 catalytic residue [active] 484021016294 H2TH interface [polypeptide binding]; other site 484021016295 putative catalytic residues [active] 484021016296 turnover-facilitating residue; other site 484021016297 intercalation triad [nucleotide binding]; other site 484021016298 8OG recognition residue [nucleotide binding]; other site 484021016299 putative reading head residues; other site 484021016300 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 484021016301 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 484021016302 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 484021016303 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 484021016304 hypothetical protein; Reviewed; Region: PRK00024 484021016305 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 484021016306 MPN+ (JAMM) motif; other site 484021016307 Zinc-binding site [ion binding]; other site 484021016308 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 484021016309 Flavoprotein; Region: Flavoprotein; pfam02441 484021016310 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 484021016311 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484021016312 trimer interface [polypeptide binding]; other site 484021016313 active site 484021016314 division inhibitor protein; Provisional; Region: slmA; PRK09480 484021016315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021016316 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 484021016317 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484021016318 active site 484021016319 ribonuclease PH; Reviewed; Region: rph; PRK00173 484021016320 Ribonuclease PH; Region: RNase_PH_bact; cd11362 484021016321 hexamer interface [polypeptide binding]; other site 484021016322 active site 484021016323 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 484021016324 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484021016325 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484021016326 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484021016327 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484021016328 Walker A/P-loop; other site 484021016329 ATP binding site [chemical binding]; other site 484021016330 Q-loop/lid; other site 484021016331 ABC transporter signature motif; other site 484021016332 Walker B; other site 484021016333 D-loop; other site 484021016334 H-loop/switch region; other site 484021016335 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 484021016336 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021016337 potential frameshift: common BLAST hit: gi|152972495|ref|YP_001337641.1| putative acetyltransferase 484021016338 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 484021016339 putative acyl-acceptor binding pocket; other site 484021016340 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 484021016341 hypothetical protein; Provisional; Region: PRK11820 484021016342 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 484021016343 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 484021016344 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 484021016345 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 484021016346 tetramer interface [polypeptide binding]; other site 484021016347 active site 484021016348 Mg2+/Mn2+ binding site [ion binding]; other site 484021016349 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 484021016350 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 484021016351 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 484021016352 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484021016353 DNA binding site [nucleotide binding] 484021016354 active site 484021016355 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 484021016356 putative ion selectivity filter; other site 484021016357 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 484021016358 putative pore gating glutamate residue; other site 484021016359 Predicted membrane protein [Function unknown]; Region: COG2860 484021016360 UPF0126 domain; Region: UPF0126; pfam03458 484021016361 UPF0126 domain; Region: UPF0126; pfam03458 484021016362 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 484021016363 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 484021016364 nucleotide binding pocket [chemical binding]; other site 484021016365 K-X-D-G motif; other site 484021016366 catalytic site [active] 484021016367 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 484021016368 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 484021016369 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 484021016370 catalytic site [active] 484021016371 G-X2-G-X-G-K; other site 484021016372 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 484021016373 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 484021016374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484021016375 Zn2+ binding site [ion binding]; other site 484021016376 Mg2+ binding site [ion binding]; other site 484021016377 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484021016378 synthetase active site [active] 484021016379 NTP binding site [chemical binding]; other site 484021016380 metal binding site [ion binding]; metal-binding site 484021016381 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 484021016382 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 484021016383 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 484021016384 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 484021016385 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 484021016386 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 484021016387 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 484021016388 generic binding surface II; other site 484021016389 ssDNA binding site; other site 484021016390 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484021016391 ATP binding site [chemical binding]; other site 484021016392 putative Mg++ binding site [ion binding]; other site 484021016393 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484021016394 nucleotide binding region [chemical binding]; other site 484021016395 ATP-binding site [chemical binding]; other site 484021016396 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 484021016397 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 484021016398 putative active site [active] 484021016399 ferredoxin-NADP reductase; Provisional; Region: PRK10926 484021016400 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 484021016401 FAD binding pocket [chemical binding]; other site 484021016402 FAD binding motif [chemical binding]; other site 484021016403 phosphate binding motif [ion binding]; other site 484021016404 beta-alpha-beta structure motif; other site 484021016405 NAD binding pocket [chemical binding]; other site 484021016406 Predicted membrane protein [Function unknown]; Region: COG3152 484021016407 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 484021016408 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 484021016409 triosephosphate isomerase; Provisional; Region: PRK14567 484021016410 substrate binding site [chemical binding]; other site 484021016411 dimer interface [polypeptide binding]; other site 484021016412 catalytic triad [active] 484021016413 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 484021016414 transmembrane helices; other site 484021016415 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 484021016416 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 484021016417 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 484021016418 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021016419 substrate binding pocket [chemical binding]; other site 484021016420 membrane-bound complex binding site; other site 484021016421 septal ring assembly protein ZapB; Provisional; Region: PRK15422 484021016422 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 484021016423 amphipathic channel; other site 484021016424 Asn-Pro-Ala signature motifs; other site 484021016425 glycerol kinase; Provisional; Region: glpK; PRK00047 484021016426 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 484021016427 N- and C-terminal domain interface [polypeptide binding]; other site 484021016428 active site 484021016429 MgATP binding site [chemical binding]; other site 484021016430 catalytic site [active] 484021016431 metal binding site [ion binding]; metal-binding site 484021016432 glycerol binding site [chemical binding]; other site 484021016433 homotetramer interface [polypeptide binding]; other site 484021016434 homodimer interface [polypeptide binding]; other site 484021016435 FBP binding site [chemical binding]; other site 484021016436 protein IIAGlc interface [polypeptide binding]; other site 484021016437 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 484021016438 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 484021016439 AsmA family; Region: AsmA; pfam05170 484021016440 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 484021016441 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021016442 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 484021016443 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021016444 active site turn [active] 484021016445 phosphorylation site [posttranslational modification] 484021016446 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 484021016447 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 484021016448 NAD(P) binding site [chemical binding]; other site 484021016449 LDH/MDH dimer interface [polypeptide binding]; other site 484021016450 substrate binding site [chemical binding]; other site 484021016451 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484021016452 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484021016453 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484021016454 putative active site [active] 484021016455 putative alpha-glucosidase; Provisional; Region: PRK10658 484021016456 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 484021016457 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 484021016458 active site 484021016459 homotrimer interface [polypeptide binding]; other site 484021016460 catalytic site [active] 484021016461 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 484021016462 putative transporter; Provisional; Region: PRK11462 484021016463 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 484021016464 integrase; Provisional; Region: PRK09692 484021016465 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 484021016466 active site 484021016467 Int/Topo IB signature motif; other site 484021016468 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 484021016469 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 484021016470 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 484021016471 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 484021016472 putative NAD(P) binding site [chemical binding]; other site 484021016473 dimer interface [polypeptide binding]; other site 484021016474 Uncharacterized conserved protein [Function unknown]; Region: COG1359 484021016475 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 484021016476 Transcriptional regulator; Region: Rrf2; cl17282 484021016477 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 484021016478 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 484021016479 putative NAD(P) binding site [chemical binding]; other site 484021016480 putative substrate binding site [chemical binding]; other site 484021016481 catalytic Zn binding site [ion binding]; other site 484021016482 structural Zn binding site [ion binding]; other site 484021016483 dimer interface [polypeptide binding]; other site 484021016484 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 484021016485 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 484021016486 conserved cys residue [active] 484021016487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021016488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021016489 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 484021016490 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 484021016491 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 484021016492 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484021016493 dimer interface [polypeptide binding]; other site 484021016494 ADP-ribose binding site [chemical binding]; other site 484021016495 active site 484021016496 nudix motif; other site 484021016497 metal binding site [ion binding]; metal-binding site 484021016498 EamA-like transporter family; Region: EamA; pfam00892 484021016499 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 484021016500 lipoprotein, YaeC family; Region: TIGR00363 484021016501 Cupin; Region: Cupin_6; pfam12852 484021016502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021016503 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 484021016504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484021016505 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 484021016506 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 484021016507 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 484021016508 SnoaL-like domain; Region: SnoaL_2; pfam12680 484021016509 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 484021016510 transcriptional regulator; Provisional; Region: PRK10632 484021016511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021016512 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 484021016513 putative effector binding pocket; other site 484021016514 putative dimerization interface [polypeptide binding]; other site 484021016515 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 484021016516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016517 putative substrate translocation pore; other site 484021016518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484021016519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484021016520 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484021016521 Coenzyme A binding pocket [chemical binding]; other site 484021016522 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021016523 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 484021016524 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 484021016525 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 484021016526 HlyD family secretion protein; Region: HlyD_3; pfam13437 484021016527 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 484021016528 Protein export membrane protein; Region: SecD_SecF; cl14618 484021016529 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 484021016530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016531 putative substrate translocation pore; other site 484021016532 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 484021016533 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 484021016534 putative active site [active] 484021016535 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 484021016536 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021016537 active site turn [active] 484021016538 phosphorylation site [posttranslational modification] 484021016539 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484021016540 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 484021016541 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 484021016542 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 484021016543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 484021016544 hypothetical protein; Provisional; Region: PRK09262 484021016545 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 484021016546 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484021016547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021016548 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 484021016549 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021016550 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 484021016551 putative dimerization interface [polypeptide binding]; other site 484021016552 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 484021016553 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 484021016554 putative active site [active] 484021016555 Fe(II) binding site [ion binding]; other site 484021016556 putative dimer interface [polypeptide binding]; other site 484021016557 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 484021016558 putative dimer interface [polypeptide binding]; other site 484021016559 putative N- and C-terminal domain interface [polypeptide binding]; other site 484021016560 benzoate transport; Region: 2A0115; TIGR00895 484021016561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016562 putative substrate translocation pore; other site 484021016563 potential frameshift: common BLAST hit: gi|206580584|ref|YP_002235925.1| transcriptional regulator, LacI family 484021016564 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484021016565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484021016566 DNA binding site [nucleotide binding] 484021016567 domain linker motif; other site 484021016568 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484021016569 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484021016570 active site 484021016571 P-loop; other site 484021016572 phosphorylation site [posttranslational modification] 484021016573 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484021016574 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484021016575 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 484021016576 methionine cluster; other site 484021016577 active site 484021016578 phosphorylation site [posttranslational modification] 484021016579 metal binding site [ion binding]; metal-binding site 484021016580 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 484021016581 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 484021016582 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021016583 dimer interface [polypeptide binding]; other site 484021016584 conserved gate region; other site 484021016585 putative PBP binding loops; other site 484021016586 ABC-ATPase subunit interface; other site 484021016587 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 484021016588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021016589 dimer interface [polypeptide binding]; other site 484021016590 conserved gate region; other site 484021016591 putative PBP binding loops; other site 484021016592 ABC-ATPase subunit interface; other site 484021016593 2-aminoethylphosphonate ABC transport system, ATP-binding component PhnT; Region: PhnT; TIGR03258 484021016594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021016595 Walker A/P-loop; other site 484021016596 ATP binding site [chemical binding]; other site 484021016597 Q-loop/lid; other site 484021016598 ABC transporter signature motif; other site 484021016599 Walker B; other site 484021016600 D-loop; other site 484021016601 H-loop/switch region; other site 484021016602 TOBE domain; Region: TOBE_2; pfam08402 484021016603 2-aminoethylphosphonate ABC transporter substrate-binding protein; Provisional; Region: PRK15046 484021016604 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 484021016605 transcriptional regulator protein; Region: phnR; TIGR03337 484021016606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021016607 DNA-binding site [nucleotide binding]; DNA binding site 484021016608 UTRA domain; Region: UTRA; pfam07702 484021016609 2-aminoethylphosphonate--pyruvate transaminase; Provisional; Region: PRK13479 484021016610 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021016611 catalytic residue [active] 484021016612 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 484021016613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021016614 motif II; other site 484021016615 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 484021016616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016617 putative substrate translocation pore; other site 484021016618 Protein of unknown function (DUF1044); Region: DUF1044; pfam06296 484021016619 Predicted transcriptional regulator [Transcription]; Region: COG2944 484021016620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484021016621 non-specific DNA binding site [nucleotide binding]; other site 484021016622 salt bridge; other site 484021016623 sequence-specific DNA binding site [nucleotide binding]; other site 484021016624 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 484021016625 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 484021016626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016627 putative substrate translocation pore; other site 484021016628 regulatory protein UhpC; Provisional; Region: PRK11663 484021016629 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016630 putative substrate translocation pore; other site 484021016631 sensory histidine kinase UhpB; Provisional; Region: PRK11644 484021016632 MASE1; Region: MASE1; pfam05231 484021016633 Histidine kinase; Region: HisKA_3; pfam07730 484021016634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021016635 ATP binding site [chemical binding]; other site 484021016636 Mg2+ binding site [ion binding]; other site 484021016637 G-X-G motif; other site 484021016638 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 484021016639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484021016640 active site 484021016641 phosphorylation site [posttranslational modification] 484021016642 intermolecular recognition site; other site 484021016643 dimerization interface [polypeptide binding]; other site 484021016644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484021016645 DNA binding residues [nucleotide binding] 484021016646 dimerization interface [polypeptide binding]; other site 484021016647 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 484021016648 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 484021016649 putative valine binding site [chemical binding]; other site 484021016650 dimer interface [polypeptide binding]; other site 484021016651 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 484021016652 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484021016653 PYR/PP interface [polypeptide binding]; other site 484021016654 dimer interface [polypeptide binding]; other site 484021016655 TPP binding site [chemical binding]; other site 484021016656 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484021016657 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 484021016658 TPP-binding site [chemical binding]; other site 484021016659 dimer interface [polypeptide binding]; other site 484021016660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484021016661 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021016662 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484021016663 Coenzyme A binding pocket [chemical binding]; other site 484021016664 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 484021016665 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 484021016666 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 484021016667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016668 putative substrate translocation pore; other site 484021016669 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 484021016670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021016671 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 484021016672 dimerization interface [polypeptide binding]; other site 484021016673 substrate binding pocket [chemical binding]; other site 484021016674 permease DsdX; Provisional; Region: PRK09921 484021016675 GntP family permease; Region: GntP_permease; pfam02447 484021016676 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 484021016677 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 484021016678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484021016679 catalytic residue [active] 484021016680 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 484021016681 Domain of unknown function (DUF202); Region: DUF202; pfam02656 484021016682 Predicted membrane protein [Function unknown]; Region: COG2149 484021016683 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 484021016684 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 484021016685 NAD binding site [chemical binding]; other site 484021016686 sugar binding site [chemical binding]; other site 484021016687 divalent metal binding site [ion binding]; other site 484021016688 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 484021016689 dimer interface [polypeptide binding]; other site 484021016690 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 484021016691 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 484021016692 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484021016693 active site turn [active] 484021016694 phosphorylation site [posttranslational modification] 484021016695 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 484021016696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021016697 DNA-binding site [nucleotide binding]; DNA binding site 484021016698 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 484021016699 putative transporter; Validated; Region: PRK03818 484021016700 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 484021016701 TrkA-C domain; Region: TrkA_C; pfam02080 484021016702 TrkA-C domain; Region: TrkA_C; pfam02080 484021016703 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 484021016704 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 484021016705 BRO family, N-terminal domain; Region: Bro-N; cl10591 484021016706 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 484021016707 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 484021016708 putative dimer interface [polypeptide binding]; other site 484021016709 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 484021016710 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 484021016711 putative dimer interface [polypeptide binding]; other site 484021016712 hypothetical protein; Provisional; Region: PRK11616 484021016713 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 484021016714 FOG: WD40 repeat [General function prediction only]; Region: COG2319 484021016715 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016716 D-galactonate transporter; Region: 2A0114; TIGR00893 484021016717 putative substrate translocation pore; other site 484021016718 galactonate dehydratase; Provisional; Region: PRK14017 484021016719 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 484021016720 putative active site pocket [active] 484021016721 putative metal binding site [ion binding]; other site 484021016722 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 484021016723 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 484021016724 active site 484021016725 intersubunit interface [polypeptide binding]; other site 484021016726 catalytic residue [active] 484021016727 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 484021016728 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 484021016729 Transcriptional regulators [Transcription]; Region: FadR; COG2186 484021016730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484021016731 DNA-binding site [nucleotide binding]; DNA binding site 484021016732 FCD domain; Region: FCD; pfam07729 484021016733 Surface antigen; Region: Bac_surface_Ag; pfam01103 484021016734 sugar phosphate phosphatase; Provisional; Region: PRK10513 484021016735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021016736 active site 484021016737 motif I; other site 484021016738 motif II; other site 484021016739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021016740 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 484021016741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484021016742 Mg2+ binding site [ion binding]; other site 484021016743 G-X-G motif; other site 484021016744 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 484021016745 anchoring element; other site 484021016746 dimer interface [polypeptide binding]; other site 484021016747 ATP binding site [chemical binding]; other site 484021016748 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 484021016749 active site 484021016750 putative metal-binding site [ion binding]; other site 484021016751 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484021016752 recF protein; Region: recf; TIGR00611 484021016753 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021016754 Walker A/P-loop; other site 484021016755 ATP binding site [chemical binding]; other site 484021016756 Q-loop/lid; other site 484021016757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484021016758 ABC transporter signature motif; other site 484021016759 Walker B; other site 484021016760 D-loop; other site 484021016761 H-loop/switch region; other site 484021016762 DNA polymerase III subunit beta; Validated; Region: PRK05643 484021016763 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 484021016764 putative DNA binding surface [nucleotide binding]; other site 484021016765 dimer interface [polypeptide binding]; other site 484021016766 beta-clamp/clamp loader binding surface; other site 484021016767 beta-clamp/translesion DNA polymerase binding surface; other site 484021016768 DnaA N-terminal domain; Region: DnaA_N; pfam11638 484021016769 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 484021016770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484021016771 Walker A motif; other site 484021016772 ATP binding site [chemical binding]; other site 484021016773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484021016774 Walker B motif; other site 484021016775 arginine finger; other site 484021016776 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 484021016777 DnaA box-binding interface [nucleotide binding]; other site 484021016778 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 484021016779 ribonuclease P; Reviewed; Region: rnpA; PRK01732 484021016780 membrane protein insertase; Provisional; Region: PRK01318 484021016781 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 484021016782 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 484021016783 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 484021016784 trmE is a tRNA modification GTPase; Region: trmE; cd04164 484021016785 G1 box; other site 484021016786 GTP/Mg2+ binding site [chemical binding]; other site 484021016787 Switch I region; other site 484021016788 G2 box; other site 484021016789 Switch II region; other site 484021016790 G3 box; other site 484021016791 G4 box; other site 484021016792 G5 box; other site 484021016793 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 484021016794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484021016795 Coenzyme A binding pocket [chemical binding]; other site 484021016796 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 484021016797 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484021016798 putative substrate translocation pore; other site 484021016799 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 484021016800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484021016801 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 484021016802 substrate binding pocket [chemical binding]; other site 484021016803 dimerization interface [polypeptide binding]; other site 484021016804 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 484021016805 Predicted flavoprotein [General function prediction only]; Region: COG0431 484021016806 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484021016807 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 484021016808 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 484021016809 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484021016810 motif II; other site 484021016811 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 484021016812 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 484021016813 active site 484021016814 trimer interface [polypeptide binding]; other site 484021016815 allosteric site; other site 484021016816 active site lid [active] 484021016817 hexamer (dimer of trimers) interface [polypeptide binding]; other site 484021016818 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 484021016819 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 484021016820 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 484021016821 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 484021016822 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 484021016823 trimer interface; other site 484021016824 sugar binding site [chemical binding]; other site 484021016825 transcriptional regulator PhoU; Provisional; Region: PRK11115 484021016826 PhoU domain; Region: PhoU; pfam01895 484021016827 PhoU domain; Region: PhoU; pfam01895 484021016828 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 484021016829 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 484021016830 Walker A/P-loop; other site 484021016831 ATP binding site [chemical binding]; other site 484021016832 Q-loop/lid; other site 484021016833 ABC transporter signature motif; other site 484021016834 Walker B; other site 484021016835 D-loop; other site 484021016836 H-loop/switch region; other site 484021016837 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 484021016838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021016839 dimer interface [polypeptide binding]; other site 484021016840 conserved gate region; other site 484021016841 putative PBP binding loops; other site 484021016842 ABC-ATPase subunit interface; other site 484021016843 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 484021016844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484021016845 dimer interface [polypeptide binding]; other site 484021016846 conserved gate region; other site 484021016847 putative PBP binding loops; other site 484021016848 ABC-ATPase subunit interface; other site 484021016849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484021016850 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 484021016851 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 484021016852 glutaminase active site [active] 484021016853 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 484021016854 dimer interface [polypeptide binding]; other site 484021016855 active site 484021016856 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 484021016857 dimer interface [polypeptide binding]; other site 484021016858 active site 484021016859 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 484021016860 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 484021016861 Substrate binding site; other site 484021016862 Mg++ binding site; other site 484021016863 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 484021016864 active site 484021016865 substrate binding site [chemical binding]; other site 484021016866 CoA binding site [chemical binding]; other site 484021016867 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 484021016868 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 484021016869 gamma subunit interface [polypeptide binding]; other site 484021016870 epsilon subunit interface [polypeptide binding]; other site 484021016871 LBP interface [polypeptide binding]; other site 484021016872 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 484021016873 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484021016874 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 484021016875 alpha subunit interaction interface [polypeptide binding]; other site 484021016876 Walker A motif; other site 484021016877 ATP binding site [chemical binding]; other site 484021016878 Walker B motif; other site 484021016879 inhibitor binding site; inhibition site 484021016880 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484021016881 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 484021016882 core domain interface [polypeptide binding]; other site 484021016883 delta subunit interface [polypeptide binding]; other site 484021016884 epsilon subunit interface [polypeptide binding]; other site 484021016885 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 484021016886 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484021016887 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 484021016888 beta subunit interaction interface [polypeptide binding]; other site 484021016889 Walker A motif; other site 484021016890 ATP binding site [chemical binding]; other site 484021016891 Walker B motif; other site 484021016892 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484021016893 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 484021016894 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 484021016895 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 484021016896 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 484021016897 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 484021016898 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 484021016899 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 484021016900 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 484021016901 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 484021016902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484021016903 S-adenosylmethionine binding site [chemical binding]; other site 484021016904 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 484021016905 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 484021016906 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932