-- dump date 20140619_121747 -- class Genbank::misc_feature -- table misc_feature_note -- id note 640131000001 membrane protein insertase; Provisional; Region: PRK01318 640131000002 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 640131000003 hypothetical protein; Validated; Region: PRK00041 640131000004 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 640131000005 DnaA N-terminal domain; Region: DnaA_N; pfam11638 640131000006 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 640131000007 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131000008 Walker A motif; other site 640131000009 ATP binding site [chemical binding]; other site 640131000010 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 640131000011 Walker B motif; other site 640131000012 arginine finger; other site 640131000013 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 640131000014 DnaA box-binding interface [nucleotide binding]; other site 640131000015 DNA polymerase III subunit beta; Validated; Region: PRK05643 640131000016 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 640131000017 putative DNA binding surface [nucleotide binding]; other site 640131000018 dimer interface [polypeptide binding]; other site 640131000019 beta-clamp/clamp loader binding surface; other site 640131000020 beta-clamp/translesion DNA polymerase binding surface; other site 640131000021 recF protein; Region: recf; TIGR00611 640131000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131000023 Walker A/P-loop; other site 640131000024 ATP binding site [chemical binding]; other site 640131000025 Q-loop/lid; other site 640131000026 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131000027 ABC transporter signature motif; other site 640131000028 Walker B; other site 640131000029 D-loop; other site 640131000030 H-loop/switch region; other site 640131000031 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 640131000032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131000033 Mg2+ binding site [ion binding]; other site 640131000034 G-X-G motif; other site 640131000035 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 640131000036 anchoring element; other site 640131000037 dimer interface [polypeptide binding]; other site 640131000038 ATP binding site [chemical binding]; other site 640131000039 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 640131000040 active site 640131000041 putative metal-binding site [ion binding]; other site 640131000042 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 640131000043 sugar phosphate phosphatase; Provisional; Region: PRK10513 640131000044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131000045 active site 640131000046 motif I; other site 640131000047 motif II; other site 640131000048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131000049 Surface antigen; Region: Bac_surface_Ag; pfam01103 640131000050 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 640131000051 FOG: WD40 repeat [General function prediction only]; Region: COG2319 640131000052 hypothetical protein; Provisional; Region: PRK11616 640131000053 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 640131000054 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 640131000055 putative dimer interface [polypeptide binding]; other site 640131000056 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 640131000057 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 640131000058 putative dimer interface [polypeptide binding]; other site 640131000059 putative transporter; Validated; Region: PRK03818 640131000060 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 640131000061 TrkA-C domain; Region: TrkA_C; pfam02080 640131000062 TrkA-C domain; Region: TrkA_C; pfam02080 640131000063 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 640131000064 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 640131000065 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131000066 DNA-binding site [nucleotide binding]; DNA binding site 640131000067 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 640131000068 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 640131000069 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 640131000070 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131000071 active site turn [active] 640131000072 phosphorylation site [posttranslational modification] 640131000073 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 640131000074 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 640131000075 NAD binding site [chemical binding]; other site 640131000076 sugar binding site [chemical binding]; other site 640131000077 divalent metal binding site [ion binding]; other site 640131000078 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131000079 dimer interface [polypeptide binding]; other site 640131000080 Predicted membrane protein [Function unknown]; Region: COG2149 640131000081 Domain of unknown function (DUF202); Region: DUF202; pfam02656 640131000082 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 640131000083 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 640131000084 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 640131000085 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131000086 catalytic residue [active] 640131000087 permease DsdX; Provisional; Region: PRK09921 640131000088 GntP family permease; Region: GntP_permease; pfam02447 640131000089 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 640131000090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131000091 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 640131000092 dimerization interface [polypeptide binding]; other site 640131000093 substrate binding pocket [chemical binding]; other site 640131000094 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 640131000095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000096 putative substrate translocation pore; other site 640131000097 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 640131000098 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 640131000099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131000100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131000101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131000102 Coenzyme A binding pocket [chemical binding]; other site 640131000103 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 640131000104 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131000105 PYR/PP interface [polypeptide binding]; other site 640131000106 dimer interface [polypeptide binding]; other site 640131000107 TPP binding site [chemical binding]; other site 640131000108 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131000109 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 640131000110 TPP-binding site [chemical binding]; other site 640131000111 dimer interface [polypeptide binding]; other site 640131000112 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 640131000113 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 640131000114 putative valine binding site [chemical binding]; other site 640131000115 dimer interface [polypeptide binding]; other site 640131000116 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 640131000117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131000118 active site 640131000119 phosphorylation site [posttranslational modification] 640131000120 intermolecular recognition site; other site 640131000121 dimerization interface [polypeptide binding]; other site 640131000122 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131000123 DNA binding residues [nucleotide binding] 640131000124 dimerization interface [polypeptide binding]; other site 640131000125 sensory histidine kinase UhpB; Provisional; Region: PRK11644 640131000126 MASE1; Region: MASE1; pfam05231 640131000127 Histidine kinase; Region: HisKA_3; pfam07730 640131000128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131000129 ATP binding site [chemical binding]; other site 640131000130 Mg2+ binding site [ion binding]; other site 640131000131 G-X-G motif; other site 640131000132 regulatory protein UhpC; Provisional; Region: PRK11663 640131000133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000134 putative substrate translocation pore; other site 640131000135 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 640131000136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000137 putative substrate translocation pore; other site 640131000138 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 640131000139 Predicted transcriptional regulator [Transcription]; Region: COG2944 640131000140 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131000141 non-specific DNA binding site [nucleotide binding]; other site 640131000142 salt bridge; other site 640131000143 sequence-specific DNA binding site [nucleotide binding]; other site 640131000144 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 640131000145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000146 putative substrate translocation pore; other site 640131000147 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 640131000148 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 640131000149 methionine cluster; other site 640131000150 active site 640131000151 phosphorylation site [posttranslational modification] 640131000152 metal binding site [ion binding]; metal-binding site 640131000153 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 640131000154 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 640131000155 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 640131000156 active site 640131000157 P-loop; other site 640131000158 phosphorylation site [posttranslational modification] 640131000159 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131000160 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131000161 DNA binding site [nucleotide binding] 640131000162 domain linker motif; other site 640131000163 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 640131000164 ligand binding site [chemical binding]; other site 640131000165 benzoate transport; Region: 2A0115; TIGR00895 640131000166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000167 putative substrate translocation pore; other site 640131000168 protocatechuate 4,5-dioxygenase; Provisional; Region: PRK13367 640131000169 The N-terminal domain of the Class III extradiol dioxygenase, Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_Doxase_N; cd07950 640131000170 putative active site [active] 640131000171 Fe(II) binding site [ion binding]; other site 640131000172 putative dimer interface [polypeptide binding]; other site 640131000173 The C-terminal domain of Gallate Dioxygenase, which catalyzes the oxidization and subsequent ring-opening of gallate; Region: Gallate_dioxygenase_C; cd07923 640131000174 putative dimer interface [polypeptide binding]; other site 640131000175 putative N- and C-terminal domain interface [polypeptide binding]; other site 640131000176 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131000177 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131000178 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 640131000179 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131000180 The C-terminal substrate binding domain of galactose-binding protein regulator contains the type 2 periplasmic binding fold; Region: PBP2_GbpR; cd08435 640131000181 putative dimerization interface [polypeptide binding]; other site 640131000182 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 640131000183 hypothetical protein; Provisional; Region: PRK09262 640131000184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 640131000185 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 640131000186 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 640131000187 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 640131000188 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 640131000189 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131000190 active site turn [active] 640131000191 phosphorylation site [posttranslational modification] 640131000192 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131000193 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 640131000194 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 640131000195 putative active site [active] 640131000196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000197 putative substrate translocation pore; other site 640131000198 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 640131000199 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 640131000200 Protein export membrane protein; Region: SecD_SecF; cl14618 640131000201 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 640131000202 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131000203 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131000204 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 640131000205 Coenzyme A binding pocket [chemical binding]; other site 640131000206 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131000207 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131000208 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 640131000209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000210 putative substrate translocation pore; other site 640131000211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131000212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131000213 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_2; cd08471 640131000214 putative effector binding pocket; other site 640131000215 putative dimerization interface [polypeptide binding]; other site 640131000216 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 640131000217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558 640131000218 SnoaL-like domain; Region: SnoaL_2; pfam12680 640131000219 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 640131000220 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 640131000221 Cupin; Region: Cupin_6; pfam12852 640131000222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131000223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131000224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131000225 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 640131000226 lipoprotein, YaeC family; Region: TIGR00363 640131000227 EamA-like transporter family; Region: EamA; pfam00892 640131000228 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 640131000229 dimer interface [polypeptide binding]; other site 640131000230 ADP-ribose binding site [chemical binding]; other site 640131000231 active site 640131000232 nudix motif; other site 640131000233 metal binding site [ion binding]; metal-binding site 640131000234 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 640131000235 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 640131000236 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 640131000237 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 640131000238 conserved cys residue [active] 640131000239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131000240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131000241 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 640131000242 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 640131000243 putative NAD(P) binding site [chemical binding]; other site 640131000244 putative substrate binding site [chemical binding]; other site 640131000245 catalytic Zn binding site [ion binding]; other site 640131000246 structural Zn binding site [ion binding]; other site 640131000247 dimer interface [polypeptide binding]; other site 640131000248 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 640131000249 Uncharacterized conserved protein [Function unknown]; Region: COG1359 640131000250 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 640131000251 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 640131000252 putative NAD(P) binding site [chemical binding]; other site 640131000253 dimer interface [polypeptide binding]; other site 640131000254 Protein of unknown function (DUF3237); Region: DUF3237; pfam11578 640131000255 putative transporter; Provisional; Region: PRK11462 640131000256 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 640131000257 putative alpha-glucosidase; Provisional; Region: PRK10658 640131000258 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 640131000259 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 640131000260 active site 640131000261 homotrimer interface [polypeptide binding]; other site 640131000262 catalytic site [active] 640131000263 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 640131000264 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 640131000265 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131000266 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 640131000267 putative active site [active] 640131000268 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 640131000269 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 640131000270 NAD(P) binding site [chemical binding]; other site 640131000271 LDH/MDH dimer interface [polypeptide binding]; other site 640131000272 substrate binding site [chemical binding]; other site 640131000273 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131000274 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 640131000275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131000276 active site turn [active] 640131000277 phosphorylation site [posttranslational modification] 640131000278 AsmA family; Region: AsmA; pfam05170 640131000279 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 640131000280 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 640131000281 glycerol kinase; Provisional; Region: glpK; PRK00047 640131000282 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 640131000283 N- and C-terminal domain interface [polypeptide binding]; other site 640131000284 active site 640131000285 MgATP binding site [chemical binding]; other site 640131000286 catalytic site [active] 640131000287 metal binding site [ion binding]; metal-binding site 640131000288 glycerol binding site [chemical binding]; other site 640131000289 homotetramer interface [polypeptide binding]; other site 640131000290 homodimer interface [polypeptide binding]; other site 640131000291 FBP binding site [chemical binding]; other site 640131000292 protein IIAGlc interface [polypeptide binding]; other site 640131000293 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 640131000294 amphipathic channel; other site 640131000295 Asn-Pro-Ala signature motifs; other site 640131000296 septal ring assembly protein ZapB; Provisional; Region: PRK15422 640131000297 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 640131000298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131000299 substrate binding pocket [chemical binding]; other site 640131000300 membrane-bound complex binding site; other site 640131000301 CDP-diacylglycerol pyrophosphatase; Provisional; Region: PRK05471 640131000302 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 640131000303 transmembrane helices; other site 640131000304 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 640131000305 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 640131000306 triosephosphate isomerase; Provisional; Region: PRK14567 640131000307 substrate binding site [chemical binding]; other site 640131000308 dimer interface [polypeptide binding]; other site 640131000309 catalytic triad [active] 640131000310 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 640131000311 Predicted membrane protein [Function unknown]; Region: COG3152 640131000312 ferredoxin-NADP reductase; Provisional; Region: PRK10926 640131000313 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 640131000314 FAD binding pocket [chemical binding]; other site 640131000315 FAD binding motif [chemical binding]; other site 640131000316 phosphate binding motif [ion binding]; other site 640131000317 beta-alpha-beta structure motif; other site 640131000318 NAD binding pocket [chemical binding]; other site 640131000319 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 640131000320 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 640131000321 putative active site [active] 640131000322 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 640131000323 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 640131000324 generic binding surface II; other site 640131000325 ssDNA binding site; other site 640131000326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131000327 ATP binding site [chemical binding]; other site 640131000328 putative Mg++ binding site [ion binding]; other site 640131000329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131000330 nucleotide binding region [chemical binding]; other site 640131000331 ATP-binding site [chemical binding]; other site 640131000332 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 640131000333 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 640131000334 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 640131000335 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 640131000336 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131000337 Zn2+ binding site [ion binding]; other site 640131000338 Mg2+ binding site [ion binding]; other site 640131000339 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 640131000340 synthetase active site [active] 640131000341 NTP binding site [chemical binding]; other site 640131000342 metal binding site [ion binding]; metal-binding site 640131000343 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 640131000344 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 640131000345 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 640131000346 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 640131000347 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 640131000348 catalytic site [active] 640131000349 G-X2-G-X-G-K; other site 640131000350 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 640131000351 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 640131000352 nucleotide binding pocket [chemical binding]; other site 640131000353 K-X-D-G motif; other site 640131000354 catalytic site [active] 640131000355 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 640131000356 Phage integrase protein; Region: DUF3701; pfam12482 640131000357 Predicted membrane protein [Function unknown]; Region: COG2860 640131000358 UPF0126 domain; Region: UPF0126; pfam03458 640131000359 UPF0126 domain; Region: UPF0126; pfam03458 640131000360 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 640131000361 putative ion selectivity filter; other site 640131000362 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 640131000363 putative pore gating glutamate residue; other site 640131000364 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 640131000365 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 640131000366 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 640131000367 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 640131000368 DNA binding site [nucleotide binding] 640131000369 active site 640131000370 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 640131000371 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 640131000372 tetramer interface [polypeptide binding]; other site 640131000373 active site 640131000374 Mg2+/Mn2+ binding site [ion binding]; other site 640131000375 hypothetical protein; Provisional; Region: PRK11820 640131000376 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 640131000377 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 640131000378 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 640131000379 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 640131000380 putative acyl-acceptor binding pocket; other site 640131000381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 640131000382 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 640131000383 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131000384 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 640131000385 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 640131000386 Walker A/P-loop; other site 640131000387 ATP binding site [chemical binding]; other site 640131000388 Q-loop/lid; other site 640131000389 ABC transporter signature motif; other site 640131000390 Walker B; other site 640131000391 D-loop; other site 640131000392 H-loop/switch region; other site 640131000393 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 640131000394 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 640131000395 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 640131000396 ribonuclease PH; Reviewed; Region: rph; PRK00173 640131000397 Ribonuclease PH; Region: RNase_PH_bact; cd11362 640131000398 hexamer interface [polypeptide binding]; other site 640131000399 active site 640131000400 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131000401 active site 640131000402 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 640131000403 division inhibitor protein; Provisional; Region: slmA; PRK09480 640131000404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131000405 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 640131000406 trimer interface [polypeptide binding]; other site 640131000407 active site 640131000408 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 640131000409 Flavoprotein; Region: Flavoprotein; pfam02441 640131000410 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 640131000411 hypothetical protein; Reviewed; Region: PRK00024 640131000412 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 640131000413 MPN+ (JAMM) motif; other site 640131000414 Zinc-binding site [ion binding]; other site 640131000415 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 640131000416 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 640131000417 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 640131000418 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 640131000419 DNA binding site [nucleotide binding] 640131000420 catalytic residue [active] 640131000421 H2TH interface [polypeptide binding]; other site 640131000422 putative catalytic residues [active] 640131000423 turnover-facilitating residue; other site 640131000424 intercalation triad [nucleotide binding]; other site 640131000425 8OG recognition residue [nucleotide binding]; other site 640131000426 putative reading head residues; other site 640131000427 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 640131000428 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 640131000429 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 640131000430 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 640131000431 active site 640131000432 (T/H)XGH motif; other site 640131000433 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 640131000434 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 640131000435 putative metal binding site; other site 640131000436 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 640131000437 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 640131000438 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 640131000439 putative glycosyl transferase; Provisional; Region: PRK10073 640131000440 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 640131000441 active site 640131000442 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131000443 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 640131000444 putative ADP-binding pocket [chemical binding]; other site 640131000445 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 640131000446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131000447 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 640131000448 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 640131000449 putative active site [active] 640131000450 Putative catalytic domain of lipopolysaccharide biosynthesis protein WalW and its bacterial homologs; Region: CE4_WalW; cd10935 640131000451 putative active site [active] 640131000452 putative catalytic site [active] 640131000453 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 640131000454 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 640131000455 O-Antigen ligase; Region: Wzy_C; pfam04932 640131000456 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK09822 640131000457 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 640131000458 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 640131000459 putative active site [active] 640131000460 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 640131000461 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 640131000462 putative active site [active] 640131000463 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 640131000464 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 640131000465 NADP binding site [chemical binding]; other site 640131000466 homopentamer interface [polypeptide binding]; other site 640131000467 substrate binding site [chemical binding]; other site 640131000468 active site 640131000469 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 640131000470 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 640131000471 substrate-cofactor binding pocket; other site 640131000472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131000473 catalytic residue [active] 640131000474 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 640131000475 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 640131000476 NAD(P) binding site [chemical binding]; other site 640131000477 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 640131000478 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 640131000479 putative metal binding site; other site 640131000480 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 640131000481 NodB motif; other site 640131000482 putative active site [active] 640131000483 putative catalytic site [active] 640131000484 Zn binding site [ion binding]; other site 640131000485 AmiB activator; Provisional; Region: PRK11637 640131000486 Vps51/Vps67; Region: Vps51; pfam08700 640131000487 Peptidase family M23; Region: Peptidase_M23; pfam01551 640131000488 phosphoglyceromutase; Provisional; Region: PRK05434 640131000489 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 640131000490 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 640131000491 active site residue [active] 640131000492 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 640131000493 GSH binding site [chemical binding]; other site 640131000494 catalytic residues [active] 640131000495 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 640131000496 SecA binding site; other site 640131000497 Preprotein binding site; other site 640131000498 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 640131000499 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 640131000500 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 640131000501 serine acetyltransferase; Provisional; Region: cysE; PRK11132 640131000502 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 640131000503 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 640131000504 trimer interface [polypeptide binding]; other site 640131000505 active site 640131000506 substrate binding site [chemical binding]; other site 640131000507 CoA binding site [chemical binding]; other site 640131000508 putative rRNA methylase; Provisional; Region: PRK10358 640131000509 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 640131000510 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 640131000511 active site 640131000512 substrate binding site [chemical binding]; other site 640131000513 FMN binding site [chemical binding]; other site 640131000514 putative catalytic residues [active] 640131000515 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 640131000516 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131000517 DNA-binding site [nucleotide binding]; DNA binding site 640131000518 FCD domain; Region: FCD; pfam07729 640131000519 L-lactate permease; Provisional; Region: PRK10420 640131000520 glycolate transporter; Provisional; Region: PRK09695 640131000521 hypothetical protein; Provisional; Region: PRK11020 640131000522 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 640131000523 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 640131000524 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 640131000525 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 640131000526 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 640131000527 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 640131000528 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 640131000529 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 640131000530 active site 640131000531 P-loop; other site 640131000532 phosphorylation site [posttranslational modification] 640131000533 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131000534 active site 640131000535 phosphorylation site [posttranslational modification] 640131000536 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 640131000537 Chorismate mutase type II; Region: CM_2; cl00693 640131000538 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 640131000539 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131000540 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131000541 putative glutathione S-transferase; Provisional; Region: PRK10357 640131000542 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 640131000543 putative C-terminal domain interface [polypeptide binding]; other site 640131000544 putative GSH binding site (G-site) [chemical binding]; other site 640131000545 putative dimer interface [polypeptide binding]; other site 640131000546 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 640131000547 dimer interface [polypeptide binding]; other site 640131000548 N-terminal domain interface [polypeptide binding]; other site 640131000549 putative substrate binding pocket (H-site) [chemical binding]; other site 640131000550 selenocysteine synthase; Provisional; Region: PRK04311 640131000551 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 640131000552 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 640131000553 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131000554 catalytic residue [active] 640131000555 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 640131000556 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 640131000557 G1 box; other site 640131000558 putative GEF interaction site [polypeptide binding]; other site 640131000559 GTP/Mg2+ binding site [chemical binding]; other site 640131000560 Switch I region; other site 640131000561 G2 box; other site 640131000562 G3 box; other site 640131000563 Switch II region; other site 640131000564 G4 box; other site 640131000565 G5 box; other site 640131000566 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 640131000567 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 640131000568 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 640131000569 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 640131000570 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 640131000571 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 640131000572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131000573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131000574 homodimer interface [polypeptide binding]; other site 640131000575 catalytic residue [active] 640131000576 alpha-amylase; Reviewed; Region: malS; PRK09505 640131000577 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 640131000578 active site 640131000579 catalytic site [active] 640131000580 hypothetical protein; Provisional; Region: PRK10356 640131000581 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 640131000582 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 640131000583 putative dimerization interface [polypeptide binding]; other site 640131000584 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131000585 putative ligand binding site [chemical binding]; other site 640131000586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131000587 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131000588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131000589 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131000590 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131000591 TM-ABC transporter signature motif; other site 640131000592 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 640131000593 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131000594 Walker A/P-loop; other site 640131000595 ATP binding site [chemical binding]; other site 640131000596 Q-loop/lid; other site 640131000597 ABC transporter signature motif; other site 640131000598 Walker B; other site 640131000599 D-loop; other site 640131000600 H-loop/switch region; other site 640131000601 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131000602 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 640131000603 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 640131000604 putative ligand binding site [chemical binding]; other site 640131000605 xylose isomerase; Provisional; Region: PRK05474 640131000606 xylose isomerase; Region: xylose_isom_A; TIGR02630 640131000607 xylulokinase; Provisional; Region: PRK15027 640131000608 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 640131000609 N- and C-terminal domain interface [polypeptide binding]; other site 640131000610 active site 640131000611 MgATP binding site [chemical binding]; other site 640131000612 catalytic site [active] 640131000613 metal binding site [ion binding]; metal-binding site 640131000614 xylulose binding site [chemical binding]; other site 640131000615 homodimer interface [polypeptide binding]; other site 640131000616 hypothetical protein; Provisional; Region: PRK11403 640131000617 yiaA/B two helix domain; Region: YiaAB; cl01759 640131000618 hypothetical protein; Provisional; Region: PRK11383 640131000619 yiaA/B two helix domain; Region: YiaAB; pfam05360 640131000620 yiaA/B two helix domain; Region: YiaAB; pfam05360 640131000621 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 640131000622 Acyltransferase family; Region: Acyl_transf_3; pfam01757 640131000623 YsaB-like lipoprotein; Region: YsaB; pfam13983 640131000624 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 640131000625 dimer interface [polypeptide binding]; other site 640131000626 motif 1; other site 640131000627 active site 640131000628 motif 2; other site 640131000629 motif 3; other site 640131000630 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 640131000631 DALR anticodon binding domain; Region: DALR_1; pfam05746 640131000632 Hok/gef family; Region: HOK_GEF; cl11494 640131000633 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 640131000634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131000635 Walker A/P-loop; other site 640131000636 ATP binding site [chemical binding]; other site 640131000637 Q-loop/lid; other site 640131000638 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131000639 ABC transporter signature motif; other site 640131000640 Walker B; other site 640131000641 D-loop; other site 640131000642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131000643 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 640131000644 DNA-binding site [nucleotide binding]; DNA binding site 640131000645 RNA-binding motif; other site 640131000646 Predicted transcriptional regulator [Transcription]; Region: COG2944 640131000647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131000648 salt bridge; other site 640131000649 non-specific DNA binding site [nucleotide binding]; other site 640131000650 sequence-specific DNA binding site [nucleotide binding]; other site 640131000651 benzoate transport; Region: 2A0115; TIGR00895 640131000652 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000653 putative substrate translocation pore; other site 640131000654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000655 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 640131000656 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 640131000657 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 640131000658 dimerization interface [polypeptide binding]; other site 640131000659 ligand binding site [chemical binding]; other site 640131000660 NADP binding site [chemical binding]; other site 640131000661 catalytic site [active] 640131000662 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000663 D-galactonate transporter; Region: 2A0114; TIGR00893 640131000664 putative substrate translocation pore; other site 640131000665 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131000666 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 640131000667 substrate binding site [chemical binding]; other site 640131000668 ATP binding site [chemical binding]; other site 640131000669 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 640131000670 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131000671 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131000672 DNA binding site [nucleotide binding] 640131000673 domain linker motif; other site 640131000674 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 640131000675 putative dimerization interface [polypeptide binding]; other site 640131000676 putative ligand binding site [chemical binding]; other site 640131000677 putative outer membrane lipoprotein; Provisional; Region: PRK10510 640131000678 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 640131000679 ligand binding site [chemical binding]; other site 640131000680 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 640131000681 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 640131000682 molybdopterin cofactor binding site [chemical binding]; other site 640131000683 substrate binding site [chemical binding]; other site 640131000684 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 640131000685 molybdopterin cofactor binding site; other site 640131000686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131000687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131000688 Coenzyme A binding pocket [chemical binding]; other site 640131000689 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 640131000690 Autotransporter beta-domain; Region: Autotransporter; cl17461 640131000691 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 640131000692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000693 putative substrate translocation pore; other site 640131000694 phosphoethanolamine transferase; Provisional; Region: PRK11560 640131000695 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 640131000696 Sulfatase; Region: Sulfatase; pfam00884 640131000697 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 640131000698 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 640131000699 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 640131000700 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 640131000701 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 640131000702 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131000703 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 640131000704 peptide binding site [polypeptide binding]; other site 640131000705 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131000706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131000707 dimer interface [polypeptide binding]; other site 640131000708 conserved gate region; other site 640131000709 putative PBP binding loops; other site 640131000710 ABC-ATPase subunit interface; other site 640131000711 dipeptide transporter; Provisional; Region: PRK10913 640131000712 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131000713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131000714 putative PBP binding loops; other site 640131000715 dimer interface [polypeptide binding]; other site 640131000716 ABC-ATPase subunit interface; other site 640131000717 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 640131000718 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131000719 Walker A/P-loop; other site 640131000720 ATP binding site [chemical binding]; other site 640131000721 Q-loop/lid; other site 640131000722 ABC transporter signature motif; other site 640131000723 Walker B; other site 640131000724 D-loop; other site 640131000725 H-loop/switch region; other site 640131000726 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 640131000727 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 640131000728 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131000729 Walker A/P-loop; other site 640131000730 ATP binding site [chemical binding]; other site 640131000731 Q-loop/lid; other site 640131000732 ABC transporter signature motif; other site 640131000733 Walker B; other site 640131000734 D-loop; other site 640131000735 H-loop/switch region; other site 640131000736 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 640131000737 cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371 640131000738 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 640131000739 P-loop; other site 640131000740 Magnesium ion binding site [ion binding]; other site 640131000741 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 640131000742 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 640131000743 DXD motif; other site 640131000744 PilZ domain; Region: PilZ; pfam07238 640131000745 cellulose synthase regulator protein; Provisional; Region: PRK11114 640131000746 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 640131000747 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 640131000748 TPR motif; other site 640131000749 binding surface 640131000750 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 640131000751 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 640131000752 Cellulose synthase subunit D; Region: Cellsynth_D; pfam03500 640131000753 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; pfam01270 640131000754 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 640131000755 Protein of unknown function (DUF2636); Region: DUF2636; pfam11120 640131000756 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 640131000757 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 640131000758 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 640131000759 cell division protein; Provisional; Region: PRK10037 640131000760 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131000761 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 640131000762 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 640131000763 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 640131000764 DXD motif; other site 640131000765 PilZ domain; Region: PilZ; pfam07238 640131000766 cellulose synthase regulator protein; Provisional; Region: PRK11114 640131000767 endo-1,4-D-glucanase; Provisional; Region: PRK11097 640131000768 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 640131000769 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 640131000770 TPR motif; other site 640131000771 binding surface 640131000772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 640131000773 binding surface 640131000774 TPR motif; other site 640131000775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 640131000776 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 640131000777 putative diguanylate cyclase; Provisional; Region: PRK13561 640131000778 HAMP domain; Region: HAMP; pfam00672 640131000779 dimerization interface [polypeptide binding]; other site 640131000780 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131000781 metal binding site [ion binding]; metal-binding site 640131000782 active site 640131000783 I-site; other site 640131000784 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131000785 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 640131000786 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 640131000787 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 640131000788 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 640131000789 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131000790 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 640131000791 substrate binding site [chemical binding]; other site 640131000792 ATP binding site [chemical binding]; other site 640131000793 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 640131000794 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 640131000795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000796 metabolite-proton symporter; Region: 2A0106; TIGR00883 640131000797 putative substrate translocation pore; other site 640131000798 inner membrane protein YhjD; Region: TIGR00766 640131000799 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131000800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131000801 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131000802 putative effector binding pocket; other site 640131000803 putative dimerization interface [polypeptide binding]; other site 640131000804 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 640131000805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131000806 NAD(P) binding site [chemical binding]; other site 640131000807 active site 640131000808 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 640131000809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131000810 trehalase; Provisional; Region: treF; PRK13270 640131000811 Trehalase; Region: Trehalase; pfam01204 640131000812 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 640131000813 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 640131000814 putative active site [active] 640131000815 metal binding site [ion binding]; metal-binding site 640131000816 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 640131000817 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 640131000818 putative C-terminal domain interface [polypeptide binding]; other site 640131000819 putative GSH binding site (G-site) [chemical binding]; other site 640131000820 putative dimer interface [polypeptide binding]; other site 640131000821 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 640131000822 putative N-terminal domain interface [polypeptide binding]; other site 640131000823 putative dimer interface [polypeptide binding]; other site 640131000824 putative substrate binding pocket (H-site) [chemical binding]; other site 640131000825 glutathione reductase; Validated; Region: PRK06116 640131000826 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131000827 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131000828 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 640131000829 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 640131000830 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 640131000831 active site 640131000832 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 640131000833 oligopeptidase A; Provisional; Region: PRK10911 640131000834 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 640131000835 active site 640131000836 Zn binding site [ion binding]; other site 640131000837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131000838 S-adenosylmethionine binding site [chemical binding]; other site 640131000839 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 640131000840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000841 putative substrate translocation pore; other site 640131000842 POT family; Region: PTR2; pfam00854 640131000843 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131000844 Ligand Binding Site [chemical binding]; other site 640131000845 universal stress protein UspB; Provisional; Region: PRK04960 640131000846 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 640131000847 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 640131000848 Predicted flavoproteins [General function prediction only]; Region: COG2081 640131000849 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131000850 FOG: CBS domain [General function prediction only]; Region: COG0517 640131000851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 640131000852 Divalent cation transporter; Region: MgtE; pfam01769 640131000853 nickel responsive regulator; Provisional; Region: PRK02967 640131000854 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 640131000855 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 640131000856 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131000857 Walker A/P-loop; other site 640131000858 ATP binding site [chemical binding]; other site 640131000859 Q-loop/lid; other site 640131000860 ABC transporter signature motif; other site 640131000861 Walker B; other site 640131000862 D-loop; other site 640131000863 H-loop/switch region; other site 640131000864 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 640131000865 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131000866 Walker A/P-loop; other site 640131000867 ATP binding site [chemical binding]; other site 640131000868 Q-loop/lid; other site 640131000869 ABC transporter signature motif; other site 640131000870 Walker B; other site 640131000871 D-loop; other site 640131000872 H-loop/switch region; other site 640131000873 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 640131000874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131000875 dimer interface [polypeptide binding]; other site 640131000876 conserved gate region; other site 640131000877 putative PBP binding loops; other site 640131000878 ABC-ATPase subunit interface; other site 640131000879 nickel transporter permease NikB; Provisional; Region: PRK10352 640131000880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131000881 dimer interface [polypeptide binding]; other site 640131000882 conserved gate region; other site 640131000883 putative PBP binding loops; other site 640131000884 ABC-ATPase subunit interface; other site 640131000885 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 640131000886 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131000887 substrate binding site [chemical binding]; other site 640131000888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131000889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131000890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131000891 dimerization interface [polypeptide binding]; other site 640131000892 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 640131000893 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 640131000894 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 640131000895 inhibitor-cofactor binding pocket; inhibition site 640131000896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131000897 catalytic residue [active] 640131000898 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 640131000899 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 640131000900 Ligand binding site; other site 640131000901 Putative Catalytic site; other site 640131000902 DXD motif; other site 640131000903 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 640131000904 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 640131000905 substrate binding site [chemical binding]; other site 640131000906 cosubstrate binding site; other site 640131000907 catalytic site [active] 640131000908 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 640131000909 active site 640131000910 hexamer interface [polypeptide binding]; other site 640131000911 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 640131000912 NAD binding site [chemical binding]; other site 640131000913 substrate binding site [chemical binding]; other site 640131000914 active site 640131000915 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 640131000916 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 640131000917 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 640131000918 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 640131000919 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 640131000920 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 640131000921 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 640131000922 Domain of unknown function DUF20; Region: UPF0118; pfam01594 640131000923 major facilitator superfamily transporter; Provisional; Region: PRK05122 640131000924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131000925 putative substrate translocation pore; other site 640131000926 hypothetical protein; Provisional; Region: PRK11615 640131000927 hypothetical protein; Provisional; Region: PRK11212 640131000928 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 640131000929 CPxP motif; other site 640131000930 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 640131000931 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 640131000932 metal-binding site [ion binding] 640131000933 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131000934 Soluble P-type ATPase [General function prediction only]; Region: COG4087 640131000935 Predicted membrane protein [Function unknown]; Region: COG3714 640131000936 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 640131000937 hypothetical protein; Provisional; Region: PRK10910 640131000938 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 640131000939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131000940 S-adenosylmethionine binding site [chemical binding]; other site 640131000941 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 640131000942 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 640131000943 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 640131000944 P loop; other site 640131000945 GTP binding site [chemical binding]; other site 640131000946 cell division protein FtsE; Provisional; Region: PRK10908 640131000947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131000948 Walker A/P-loop; other site 640131000949 ATP binding site [chemical binding]; other site 640131000950 Q-loop/lid; other site 640131000951 ABC transporter signature motif; other site 640131000952 Walker B; other site 640131000953 D-loop; other site 640131000954 H-loop/switch region; other site 640131000955 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 640131000956 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 640131000957 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 640131000958 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 640131000959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 640131000960 DNA binding residues [nucleotide binding] 640131000961 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131000962 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131000963 DNA-binding site [nucleotide binding]; DNA binding site 640131000964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131000965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131000966 homodimer interface [polypeptide binding]; other site 640131000967 catalytic residue [active] 640131000968 4-aminobutyrate aminotransferase; Provisional; Region: PRK06777 640131000969 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131000970 inhibitor-cofactor binding pocket; inhibition site 640131000971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131000972 catalytic residue [active] 640131000973 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 640131000974 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 640131000975 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 640131000976 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 640131000977 dimerization interface [polypeptide binding]; other site 640131000978 ligand binding site [chemical binding]; other site 640131000979 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 640131000980 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 640131000981 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 640131000982 dimerization interface [polypeptide binding]; other site 640131000983 ligand binding site [chemical binding]; other site 640131000984 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131000985 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 640131000986 TM-ABC transporter signature motif; other site 640131000987 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 640131000988 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 640131000989 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 640131000990 TM-ABC transporter signature motif; other site 640131000991 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 640131000992 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 640131000993 Walker A/P-loop; other site 640131000994 ATP binding site [chemical binding]; other site 640131000995 Q-loop/lid; other site 640131000996 ABC transporter signature motif; other site 640131000997 Walker B; other site 640131000998 D-loop; other site 640131000999 H-loop/switch region; other site 640131001000 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 640131001001 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 640131001002 Walker A/P-loop; other site 640131001003 ATP binding site [chemical binding]; other site 640131001004 Q-loop/lid; other site 640131001005 ABC transporter signature motif; other site 640131001006 Walker B; other site 640131001007 D-loop; other site 640131001008 H-loop/switch region; other site 640131001009 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 640131001010 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 640131001011 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 640131001012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 640131001013 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 640131001014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131001015 putative PBP binding loops; other site 640131001016 dimer interface [polypeptide binding]; other site 640131001017 ABC-ATPase subunit interface; other site 640131001018 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131001020 dimer interface [polypeptide binding]; other site 640131001021 conserved gate region; other site 640131001022 putative PBP binding loops; other site 640131001023 ABC-ATPase subunit interface; other site 640131001024 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 640131001025 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131001026 Walker A/P-loop; other site 640131001027 ATP binding site [chemical binding]; other site 640131001028 Q-loop/lid; other site 640131001029 ABC transporter signature motif; other site 640131001030 Walker B; other site 640131001031 D-loop; other site 640131001032 H-loop/switch region; other site 640131001033 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 640131001034 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 640131001035 putative active site [active] 640131001036 catalytic site [active] 640131001037 putative metal binding site [ion binding]; other site 640131001038 Protein of unknown function (DUF2756); Region: DUF2756; cl08110 640131001039 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 640131001040 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 640131001041 putative acetyltransferase YhhY; Provisional; Region: PRK10140 640131001042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131001043 Coenzyme A binding pocket [chemical binding]; other site 640131001044 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 640131001045 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 640131001046 putative oxidoreductase; Provisional; Region: PRK10206 640131001047 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131001048 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131001049 Pirin-related protein [General function prediction only]; Region: COG1741 640131001050 Pirin; Region: Pirin; pfam02678 640131001051 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 640131001052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131001053 DNA binding site [nucleotide binding] 640131001054 domain linker motif; other site 640131001055 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 640131001056 putative ligand binding site [chemical binding]; other site 640131001057 putative dimerization interface [polypeptide binding]; other site 640131001058 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 640131001059 ATP-binding site [chemical binding]; other site 640131001060 Gluconate-6-phosphate binding site [chemical binding]; other site 640131001061 low affinity gluconate transporter; Provisional; Region: PRK10472 640131001062 gluconate transporter; Region: gntP; TIGR00791 640131001063 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 640131001064 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 640131001065 glycogen branching enzyme; Provisional; Region: PRK05402 640131001066 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 640131001067 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 640131001068 active site 640131001069 catalytic site [active] 640131001070 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 640131001071 glycogen debranching enzyme; Provisional; Region: PRK03705 640131001072 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 640131001073 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 640131001074 active site 640131001075 catalytic site [active] 640131001076 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 640131001077 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 640131001078 ligand binding site; other site 640131001079 oligomer interface; other site 640131001080 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 640131001081 dimer interface [polypeptide binding]; other site 640131001082 N-terminal domain interface [polypeptide binding]; other site 640131001083 sulfate 1 binding site; other site 640131001084 glycogen synthase; Provisional; Region: glgA; PRK00654 640131001085 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 640131001086 ADP-binding pocket [chemical binding]; other site 640131001087 homodimer interface [polypeptide binding]; other site 640131001088 glycogen phosphorylase; Provisional; Region: PRK14986 640131001089 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 640131001090 homodimer interface [polypeptide binding]; other site 640131001091 active site pocket [active] 640131001092 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 640131001093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131001094 non-specific DNA binding site [nucleotide binding]; other site 640131001095 salt bridge; other site 640131001096 sequence-specific DNA binding site [nucleotide binding]; other site 640131001097 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 640131001098 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 640131001099 active site residue [active] 640131001100 intramembrane serine protease GlpG; Provisional; Region: PRK10907 640131001101 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 640131001102 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 640131001103 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 640131001104 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 640131001105 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131001106 transcriptional regulator MalT; Provisional; Region: PRK04841 640131001107 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131001108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131001109 DNA binding residues [nucleotide binding] 640131001110 dimerization interface [polypeptide binding]; other site 640131001111 maltodextrin phosphorylase; Provisional; Region: PRK14985 640131001112 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 640131001113 homodimer interface [polypeptide binding]; other site 640131001114 active site pocket [active] 640131001115 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 640131001116 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 640131001117 high-affinity gluconate transporter; Provisional; Region: PRK14984 640131001118 gluconate transporter; Region: gntP; TIGR00791 640131001119 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 640131001120 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 640131001121 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 640131001122 DNA utilization protein GntX; Provisional; Region: PRK11595 640131001123 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131001124 active site 640131001125 carboxylesterase BioH; Provisional; Region: PRK10349 640131001126 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 640131001127 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131001128 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 640131001129 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 640131001130 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 640131001131 G1 box; other site 640131001132 GTP/Mg2+ binding site [chemical binding]; other site 640131001133 Switch I region; other site 640131001134 G2 box; other site 640131001135 G3 box; other site 640131001136 Switch II region; other site 640131001137 G4 box; other site 640131001138 G5 box; other site 640131001139 Nucleoside recognition; Region: Gate; pfam07670 640131001140 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 640131001141 Nucleoside recognition; Region: Gate; pfam07670 640131001142 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 640131001143 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 640131001144 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 640131001145 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 640131001146 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 640131001147 RNA binding site [nucleotide binding]; other site 640131001148 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 640131001149 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 640131001150 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 640131001151 osmolarity response regulator; Provisional; Region: ompR; PRK09468 640131001152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131001153 active site 640131001154 phosphorylation site [posttranslational modification] 640131001155 intermolecular recognition site; other site 640131001156 dimerization interface [polypeptide binding]; other site 640131001157 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131001158 DNA binding site [nucleotide binding] 640131001159 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 640131001160 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131001161 dimerization interface [polypeptide binding]; other site 640131001162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131001163 dimer interface [polypeptide binding]; other site 640131001164 phosphorylation site [posttranslational modification] 640131001165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131001166 ATP binding site [chemical binding]; other site 640131001167 Mg2+ binding site [ion binding]; other site 640131001168 G-X-G motif; other site 640131001169 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 640131001170 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 640131001171 active site 640131001172 substrate-binding site [chemical binding]; other site 640131001173 metal-binding site [ion binding] 640131001174 ATP binding site [chemical binding]; other site 640131001175 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 640131001176 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 640131001177 dimerization interface [polypeptide binding]; other site 640131001178 domain crossover interface; other site 640131001179 redox-dependent activation switch; other site 640131001180 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131001181 RNA binding surface [nucleotide binding]; other site 640131001182 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 640131001183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131001184 motif II; other site 640131001185 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 640131001186 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 640131001187 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 640131001188 ADP-ribose binding site [chemical binding]; other site 640131001189 dimer interface [polypeptide binding]; other site 640131001190 active site 640131001191 nudix motif; other site 640131001192 metal binding site [ion binding]; metal-binding site 640131001193 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 640131001194 Transglycosylase; Region: Transgly; pfam00912 640131001195 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 640131001196 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 640131001197 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 640131001198 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 640131001199 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 640131001200 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 640131001201 shikimate kinase; Reviewed; Region: aroK; PRK00131 640131001202 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 640131001203 ADP binding site [chemical binding]; other site 640131001204 magnesium binding site [ion binding]; other site 640131001205 putative shikimate binding site; other site 640131001206 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 640131001207 active site 640131001208 dimer interface [polypeptide binding]; other site 640131001209 metal binding site [ion binding]; metal-binding site 640131001210 cell division protein DamX; Validated; Region: PRK10905 640131001211 hypothetical protein; Reviewed; Region: PRK11901 640131001212 DNA adenine methylase; Provisional; Region: PRK10904 640131001213 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 640131001214 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 640131001215 substrate binding site [chemical binding]; other site 640131001216 hexamer interface [polypeptide binding]; other site 640131001217 metal binding site [ion binding]; metal-binding site 640131001218 phosphoglycolate phosphatase; Provisional; Region: PRK13222 640131001219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131001220 motif II; other site 640131001221 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 640131001222 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 640131001223 active site 640131001224 HIGH motif; other site 640131001225 dimer interface [polypeptide binding]; other site 640131001226 KMSKS motif; other site 640131001227 siroheme synthase; Provisional; Region: cysG; PRK10637 640131001228 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 640131001229 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 640131001230 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 640131001231 active site 640131001232 SAM binding site [chemical binding]; other site 640131001233 homodimer interface [polypeptide binding]; other site 640131001234 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 640131001235 nitrite reductase subunit NirD; Provisional; Region: PRK14989 640131001236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131001237 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 640131001238 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 640131001239 cytosine deaminase; Provisional; Region: PRK09230 640131001240 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 640131001241 active site 640131001242 putative transporter; Provisional; Region: PRK03699 640131001243 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131001244 putative substrate translocation pore; other site 640131001245 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 640131001246 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 640131001247 substrate binding site [chemical binding]; other site 640131001248 hypothetical protein; Provisional; Region: PRK10204 640131001249 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 640131001250 cell filamentation protein Fic; Provisional; Region: PRK10347 640131001251 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 640131001252 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 640131001253 glutamine binding [chemical binding]; other site 640131001254 catalytic triad [active] 640131001255 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 640131001256 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131001257 inhibitor-cofactor binding pocket; inhibition site 640131001258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131001259 catalytic residue [active] 640131001260 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 640131001261 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 640131001262 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 640131001263 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 640131001264 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 640131001265 ligand binding site [chemical binding]; other site 640131001266 flexible hinge region; other site 640131001267 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 640131001268 putative switch regulator; other site 640131001269 non-specific DNA interactions [nucleotide binding]; other site 640131001270 DNA binding site [nucleotide binding] 640131001271 sequence specific DNA binding site [nucleotide binding]; other site 640131001272 putative cAMP binding site [chemical binding]; other site 640131001273 hypothetical protein; Provisional; Region: PRK10738 640131001274 phosphoribulokinase; Provisional; Region: PRK15453 640131001275 active site 640131001276 hypothetical protein; Provisional; Region: PRK04966 640131001277 putative hydrolase; Provisional; Region: PRK10985 640131001278 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 640131001279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131001280 Walker A/P-loop; other site 640131001281 ATP binding site [chemical binding]; other site 640131001282 Q-loop/lid; other site 640131001283 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131001284 ABC transporter signature motif; other site 640131001285 Walker B; other site 640131001286 D-loop; other site 640131001287 ABC transporter; Region: ABC_tran_2; pfam12848 640131001288 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131001289 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 640131001290 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 640131001291 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 640131001292 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 640131001293 TrkA-N domain; Region: TrkA_N; pfam02254 640131001294 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 640131001295 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737 640131001296 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 640131001297 phi X174 lysis protein; Provisional; Region: PRK02793 640131001298 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 640131001299 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 640131001300 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 640131001301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 640131001302 YheO-like PAS domain; Region: PAS_6; pfam08348 640131001303 HTH domain; Region: HTH_22; pfam13309 640131001304 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 640131001305 sulfur relay protein TusC; Validated; Region: PRK00211 640131001306 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 640131001307 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 640131001308 S17 interaction site [polypeptide binding]; other site 640131001309 S8 interaction site; other site 640131001310 16S rRNA interaction site [nucleotide binding]; other site 640131001311 streptomycin interaction site [chemical binding]; other site 640131001312 23S rRNA interaction site [nucleotide binding]; other site 640131001313 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 640131001314 30S ribosomal protein S7; Validated; Region: PRK05302 640131001315 elongation factor G; Reviewed; Region: PRK00007 640131001316 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 640131001317 G1 box; other site 640131001318 putative GEF interaction site [polypeptide binding]; other site 640131001319 GTP/Mg2+ binding site [chemical binding]; other site 640131001320 Switch I region; other site 640131001321 G2 box; other site 640131001322 G3 box; other site 640131001323 Switch II region; other site 640131001324 G4 box; other site 640131001325 G5 box; other site 640131001326 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 640131001327 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 640131001328 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 640131001329 elongation factor Tu; Reviewed; Region: PRK00049 640131001330 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 640131001331 G1 box; other site 640131001332 GEF interaction site [polypeptide binding]; other site 640131001333 GTP/Mg2+ binding site [chemical binding]; other site 640131001334 Switch I region; other site 640131001335 G2 box; other site 640131001336 G3 box; other site 640131001337 Switch II region; other site 640131001338 G4 box; other site 640131001339 G5 box; other site 640131001340 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 640131001341 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 640131001342 Antibiotic Binding Site [chemical binding]; other site 640131001343 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 640131001344 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 640131001345 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 640131001346 heme binding site [chemical binding]; other site 640131001347 ferroxidase pore; other site 640131001348 ferroxidase diiron center [ion binding]; other site 640131001349 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 640131001350 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 640131001351 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 640131001352 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 640131001353 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 640131001354 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 640131001355 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 640131001356 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 640131001357 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 640131001358 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 640131001359 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 640131001360 protein-rRNA interface [nucleotide binding]; other site 640131001361 putative translocon binding site; other site 640131001362 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 640131001363 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 640131001364 G-X-X-G motif; other site 640131001365 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 640131001366 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 640131001367 23S rRNA interface [nucleotide binding]; other site 640131001368 5S rRNA interface [nucleotide binding]; other site 640131001369 putative antibiotic binding site [chemical binding]; other site 640131001370 L25 interface [polypeptide binding]; other site 640131001371 L27 interface [polypeptide binding]; other site 640131001372 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 640131001373 23S rRNA interface [nucleotide binding]; other site 640131001374 putative translocon interaction site; other site 640131001375 signal recognition particle (SRP54) interaction site; other site 640131001376 L23 interface [polypeptide binding]; other site 640131001377 trigger factor interaction site; other site 640131001378 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 640131001379 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 640131001380 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 640131001381 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 640131001382 RNA binding site [nucleotide binding]; other site 640131001383 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 640131001384 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 640131001385 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 640131001386 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 640131001387 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 640131001388 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 640131001389 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 640131001390 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 640131001391 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 640131001392 23S rRNA interface [nucleotide binding]; other site 640131001393 5S rRNA interface [nucleotide binding]; other site 640131001394 L27 interface [polypeptide binding]; other site 640131001395 L5 interface [polypeptide binding]; other site 640131001396 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 640131001397 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 640131001398 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 640131001399 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 640131001400 23S rRNA binding site [nucleotide binding]; other site 640131001401 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 640131001402 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 640131001403 SecY translocase; Region: SecY; pfam00344 640131001404 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 640131001405 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 640131001406 30S ribosomal protein S13; Region: bact_S13; TIGR03631 640131001407 30S ribosomal protein S11; Validated; Region: PRK05309 640131001408 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 640131001409 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 640131001410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131001411 RNA binding surface [nucleotide binding]; other site 640131001412 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 640131001413 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 640131001414 alphaNTD homodimer interface [polypeptide binding]; other site 640131001415 alphaNTD - beta interaction site [polypeptide binding]; other site 640131001416 alphaNTD - beta' interaction site [polypeptide binding]; other site 640131001417 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 640131001418 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 640131001419 hypothetical protein; Provisional; Region: PRK10203 640131001420 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 640131001421 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 640131001422 DNA binding residues [nucleotide binding] 640131001423 dimer interface [polypeptide binding]; other site 640131001424 metal binding site [ion binding]; metal-binding site 640131001425 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 640131001426 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 640131001427 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 640131001428 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 640131001429 TrkA-N domain; Region: TrkA_N; pfam02254 640131001430 TrkA-C domain; Region: TrkA_C; pfam02080 640131001431 TrkA-N domain; Region: TrkA_N; pfam02254 640131001432 TrkA-C domain; Region: TrkA_C; pfam02080 640131001433 16S rRNA methyltransferase B; Provisional; Region: PRK10901 640131001434 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 640131001435 putative RNA binding site [nucleotide binding]; other site 640131001436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131001437 S-adenosylmethionine binding site [chemical binding]; other site 640131001438 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 640131001439 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 640131001440 putative active site [active] 640131001441 substrate binding site [chemical binding]; other site 640131001442 putative cosubstrate binding site; other site 640131001443 catalytic site [active] 640131001444 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 640131001445 substrate binding site [chemical binding]; other site 640131001446 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 640131001447 active site 640131001448 catalytic residues [active] 640131001449 metal binding site [ion binding]; metal-binding site 640131001450 hypothetical protein; Provisional; Region: PRK10736 640131001451 DNA protecting protein DprA; Region: dprA; TIGR00732 640131001452 hypothetical protein; Validated; Region: PRK03430 640131001453 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 640131001454 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 640131001455 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 640131001456 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 640131001457 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 640131001458 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 640131001459 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 640131001460 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 640131001461 shikimate binding site; other site 640131001462 NAD(P) binding site [chemical binding]; other site 640131001463 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 640131001464 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 640131001465 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 640131001466 trimer interface [polypeptide binding]; other site 640131001467 putative metal binding site [ion binding]; other site 640131001468 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 640131001469 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 640131001470 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 640131001471 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 640131001472 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131001473 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131001474 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 640131001475 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131001476 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 640131001477 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 640131001478 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 640131001479 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 640131001480 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 640131001481 FMN binding site [chemical binding]; other site 640131001482 active site 640131001483 catalytic residues [active] 640131001484 substrate binding site [chemical binding]; other site 640131001485 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 640131001486 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 640131001487 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 640131001488 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 640131001489 Na binding site [ion binding]; other site 640131001490 hypothetical protein; Provisional; Region: PRK10633 640131001491 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 640131001492 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 640131001493 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 640131001494 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 640131001495 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 640131001496 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 640131001497 carboxyltransferase (CT) interaction site; other site 640131001498 biotinylation site [posttranslational modification]; other site 640131001499 Dehydroquinase class II; Region: DHquinase_II; pfam01220 640131001500 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 640131001501 trimer interface [polypeptide binding]; other site 640131001502 active site 640131001503 dimer interface [polypeptide binding]; other site 640131001504 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 640131001505 TMAO/DMSO reductase; Reviewed; Region: PRK05363 640131001506 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 640131001507 Moco binding site; other site 640131001508 metal coordination site [ion binding]; other site 640131001509 regulatory protein CsrD; Provisional; Region: PRK11059 640131001510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131001511 metal binding site [ion binding]; metal-binding site 640131001512 active site 640131001513 I-site; other site 640131001514 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131001515 rod shape-determining protein MreB; Provisional; Region: PRK13927 640131001516 MreB and similar proteins; Region: MreB_like; cd10225 640131001517 nucleotide binding site [chemical binding]; other site 640131001518 Mg binding site [ion binding]; other site 640131001519 putative protofilament interaction site [polypeptide binding]; other site 640131001520 RodZ interaction site [polypeptide binding]; other site 640131001521 rod shape-determining protein MreC; Region: mreC; TIGR00219 640131001522 rod shape-determining protein MreC; Region: MreC; pfam04085 640131001523 rod shape-determining protein MreD; Provisional; Region: PRK11060 640131001524 Maf-like protein; Region: Maf; pfam02545 640131001525 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 640131001526 active site 640131001527 dimer interface [polypeptide binding]; other site 640131001528 ribonuclease G; Provisional; Region: PRK11712 640131001529 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 640131001530 homodimer interface [polypeptide binding]; other site 640131001531 oligonucleotide binding site [chemical binding]; other site 640131001532 hypothetical protein; Provisional; Region: PRK10899 640131001533 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 640131001534 protease TldD; Provisional; Region: tldD; PRK10735 640131001535 transcriptional regulator; Provisional; Region: PRK10632 640131001536 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131001537 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131001538 putative effector binding pocket; other site 640131001539 dimerization interface [polypeptide binding]; other site 640131001540 efflux system membrane protein; Provisional; Region: PRK11594 640131001541 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 640131001542 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131001543 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131001544 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 640131001545 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 640131001546 Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027 640131001547 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 640131001548 RNAase interaction site [polypeptide binding]; other site 640131001549 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131001550 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131001551 arginine repressor; Provisional; Region: PRK05066 640131001552 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 640131001553 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 640131001554 malate dehydrogenase; Provisional; Region: PRK05086 640131001555 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 640131001556 NAD binding site [chemical binding]; other site 640131001557 dimerization interface [polypeptide binding]; other site 640131001558 Substrate binding site [chemical binding]; other site 640131001559 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131001560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131001561 DNA-binding site [nucleotide binding]; DNA binding site 640131001562 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131001563 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131001564 DNA-binding site [nucleotide binding]; DNA binding site 640131001565 FCD domain; Region: FCD; pfam07729 640131001566 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 640131001567 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 640131001568 transmembrane helices; other site 640131001569 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 640131001570 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 640131001571 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 640131001572 oxaloacetate decarboxylase; Provisional; Region: PRK14040 640131001573 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 640131001574 active site 640131001575 catalytic residues [active] 640131001576 metal binding site [ion binding]; metal-binding site 640131001577 homodimer binding site [polypeptide binding]; other site 640131001578 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 640131001579 carboxyltransferase (CT) interaction site; other site 640131001580 biotinylation site [posttranslational modification]; other site 640131001581 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 640131001582 Triphosphoribosyl-dephospho-CoA synthetase [Coenzyme metabolism]; Region: CitG; COG1767 640131001583 serine endoprotease; Provisional; Region: PRK10898 640131001584 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 640131001585 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 640131001586 protein binding site [polypeptide binding]; other site 640131001587 serine endoprotease; Provisional; Region: PRK10139 640131001588 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 640131001589 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 640131001590 protein binding site [polypeptide binding]; other site 640131001591 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 640131001592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 640131001593 hypothetical protein; Provisional; Region: PRK11677 640131001594 Predicted ATPase [General function prediction only]; Region: COG1485 640131001595 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 640131001596 23S rRNA interface [nucleotide binding]; other site 640131001597 L3 interface [polypeptide binding]; other site 640131001598 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 640131001599 stringent starvation protein A; Provisional; Region: sspA; PRK09481 640131001600 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 640131001601 C-terminal domain interface [polypeptide binding]; other site 640131001602 putative GSH binding site (G-site) [chemical binding]; other site 640131001603 dimer interface [polypeptide binding]; other site 640131001604 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 640131001605 dimer interface [polypeptide binding]; other site 640131001606 N-terminal domain interface [polypeptide binding]; other site 640131001607 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 640131001608 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 640131001609 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 640131001610 putative active site cavity [active] 640131001611 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 640131001612 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 640131001613 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131001614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131001615 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 640131001616 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 640131001617 active site 640131001618 dimer interface [polypeptide binding]; other site 640131001619 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 640131001620 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 640131001621 active site 640131001622 FMN binding site [chemical binding]; other site 640131001623 substrate binding site [chemical binding]; other site 640131001624 3Fe-4S cluster binding site [ion binding]; other site 640131001625 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 640131001626 domain interface; other site 640131001627 radical SAM protein, TIGR01212 family; Region: TIGR01212 640131001628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131001629 FeS/SAM binding site; other site 640131001630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131001631 D-galactonate transporter; Region: 2A0114; TIGR00893 640131001632 putative substrate translocation pore; other site 640131001633 putative oxidoreductase; Provisional; Region: PRK10083 640131001634 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 640131001635 putative NAD(P) binding site [chemical binding]; other site 640131001636 catalytic Zn binding site [ion binding]; other site 640131001637 structural Zn binding site [ion binding]; other site 640131001638 mannonate dehydratase; Provisional; Region: PRK03906 640131001639 mannonate dehydratase; Region: uxuA; TIGR00695 640131001640 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 640131001641 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131001642 putative active site [active] 640131001643 heme pocket [chemical binding]; other site 640131001644 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131001645 dimer interface [polypeptide binding]; other site 640131001646 phosphorylation site [posttranslational modification] 640131001647 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131001648 ATP binding site [chemical binding]; other site 640131001649 Mg2+ binding site [ion binding]; other site 640131001650 G-X-G motif; other site 640131001651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131001652 active site 640131001653 phosphorylation site [posttranslational modification] 640131001654 intermolecular recognition site; other site 640131001655 dimerization interface [polypeptide binding]; other site 640131001656 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 640131001657 putative binding surface; other site 640131001658 active site 640131001659 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 640131001660 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 640131001661 conserved cys residue [active] 640131001662 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 640131001663 Transglycosylase; Region: Transgly; cl17702 640131001664 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 640131001665 dimerization domain swap beta strand [polypeptide binding]; other site 640131001666 regulatory protein interface [polypeptide binding]; other site 640131001667 active site 640131001668 regulatory phosphorylation site [posttranslational modification]; other site 640131001669 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 640131001670 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131001671 active site 640131001672 phosphorylation site [posttranslational modification] 640131001673 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 640131001674 30S subunit binding site; other site 640131001675 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 640131001676 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 640131001677 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 640131001678 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 640131001679 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 640131001680 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 640131001681 Walker A/P-loop; other site 640131001682 ATP binding site [chemical binding]; other site 640131001683 Q-loop/lid; other site 640131001684 ABC transporter signature motif; other site 640131001685 Walker B; other site 640131001686 D-loop; other site 640131001687 H-loop/switch region; other site 640131001688 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 640131001689 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 640131001690 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 640131001691 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 640131001692 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 640131001693 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 640131001694 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 640131001695 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 640131001696 putative active site [active] 640131001697 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 640131001698 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 640131001699 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 640131001700 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 640131001701 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 640131001702 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 640131001703 Walker A/P-loop; other site 640131001704 ATP binding site [chemical binding]; other site 640131001705 Q-loop/lid; other site 640131001706 ABC transporter signature motif; other site 640131001707 Walker B; other site 640131001708 D-loop; other site 640131001709 H-loop/switch region; other site 640131001710 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 640131001711 conserved hypothetical integral membrane protein; Region: TIGR00056 640131001712 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 640131001713 mce related protein; Region: MCE; pfam02470 640131001714 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 640131001715 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 640131001716 anti sigma factor interaction site; other site 640131001717 regulatory phosphorylation site [posttranslational modification]; other site 640131001718 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 640131001719 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 640131001720 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 640131001721 hinge; other site 640131001722 active site 640131001723 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 640131001724 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 640131001725 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 640131001726 substrate binding pocket [chemical binding]; other site 640131001727 chain length determination region; other site 640131001728 substrate-Mg2+ binding site; other site 640131001729 catalytic residues [active] 640131001730 aspartate-rich region 1; other site 640131001731 active site lid residues [active] 640131001732 aspartate-rich region 2; other site 640131001733 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 640131001734 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 640131001735 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 640131001736 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 640131001737 EamA-like transporter family; Region: EamA; pfam00892 640131001738 GTPase CgtA; Reviewed; Region: obgE; PRK12298 640131001739 GTP1/OBG; Region: GTP1_OBG; pfam01018 640131001740 Obg GTPase; Region: Obg; cd01898 640131001741 G1 box; other site 640131001742 GTP/Mg2+ binding site [chemical binding]; other site 640131001743 Switch I region; other site 640131001744 G2 box; other site 640131001745 G3 box; other site 640131001746 Switch II region; other site 640131001747 G4 box; other site 640131001748 G5 box; other site 640131001749 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 640131001750 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 640131001751 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 640131001752 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 640131001753 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 640131001754 RNA-binding protein YhbY; Provisional; Region: PRK10343 640131001755 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 640131001756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131001757 S-adenosylmethionine binding site [chemical binding]; other site 640131001758 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 640131001759 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131001760 Walker A motif; other site 640131001761 ATP binding site [chemical binding]; other site 640131001762 Walker B motif; other site 640131001763 arginine finger; other site 640131001764 Peptidase family M41; Region: Peptidase_M41; pfam01434 640131001765 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 640131001766 dihydropteroate synthase; Region: DHPS; TIGR01496 640131001767 substrate binding pocket [chemical binding]; other site 640131001768 dimer interface [polypeptide binding]; other site 640131001769 inhibitor binding site; inhibition site 640131001770 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 640131001771 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 640131001772 active site 640131001773 substrate binding site [chemical binding]; other site 640131001774 metal binding site [ion binding]; metal-binding site 640131001775 Preprotein translocase SecG subunit; Region: SecG; pfam03840 640131001776 YfaZ precursor; Region: YfaZ; pfam07437 640131001777 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 640131001778 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 640131001779 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 640131001780 argininosuccinate synthase; Validated; Region: PRK05370 640131001781 argininosuccinate synthase; Provisional; Region: PRK13820 640131001782 ribosome maturation protein RimP; Reviewed; Region: PRK00092 640131001783 Sm and related proteins; Region: Sm_like; cl00259 640131001784 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 640131001785 putative oligomer interface [polypeptide binding]; other site 640131001786 putative RNA binding site [nucleotide binding]; other site 640131001787 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 640131001788 NusA N-terminal domain; Region: NusA_N; pfam08529 640131001789 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 640131001790 RNA binding site [nucleotide binding]; other site 640131001791 homodimer interface [polypeptide binding]; other site 640131001792 NusA-like KH domain; Region: KH_5; pfam13184 640131001793 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 640131001794 G-X-X-G motif; other site 640131001795 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 640131001796 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 640131001797 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 640131001798 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 640131001799 translation initiation factor IF-2; Region: IF-2; TIGR00487 640131001800 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 640131001801 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 640131001802 G1 box; other site 640131001803 putative GEF interaction site [polypeptide binding]; other site 640131001804 GTP/Mg2+ binding site [chemical binding]; other site 640131001805 Switch I region; other site 640131001806 G2 box; other site 640131001807 G3 box; other site 640131001808 Switch II region; other site 640131001809 G4 box; other site 640131001810 G5 box; other site 640131001811 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 640131001812 Translation-initiation factor 2; Region: IF-2; pfam11987 640131001813 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 640131001814 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 640131001815 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 640131001816 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 640131001817 RNA binding site [nucleotide binding]; other site 640131001818 active site 640131001819 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 640131001820 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 640131001821 16S/18S rRNA binding site [nucleotide binding]; other site 640131001822 S13e-L30e interaction site [polypeptide binding]; other site 640131001823 25S rRNA binding site [nucleotide binding]; other site 640131001824 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 640131001825 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 640131001826 RNase E interface [polypeptide binding]; other site 640131001827 trimer interface [polypeptide binding]; other site 640131001828 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 640131001829 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 640131001830 RNase E interface [polypeptide binding]; other site 640131001831 trimer interface [polypeptide binding]; other site 640131001832 active site 640131001833 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 640131001834 putative nucleic acid binding region [nucleotide binding]; other site 640131001835 G-X-X-G motif; other site 640131001836 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 640131001837 RNA binding site [nucleotide binding]; other site 640131001838 domain interface; other site 640131001839 lipoprotein NlpI; Provisional; Region: PRK11189 640131001840 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 640131001841 binding surface 640131001842 TPR motif; other site 640131001843 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 640131001844 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 640131001845 ATP binding site [chemical binding]; other site 640131001846 Mg++ binding site [ion binding]; other site 640131001847 motif III; other site 640131001848 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131001849 nucleotide binding region [chemical binding]; other site 640131001850 ATP-binding site [chemical binding]; other site 640131001851 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 640131001852 putative RNA binding site [nucleotide binding]; other site 640131001853 tryptophan permease; Provisional; Region: PRK10483 640131001854 aromatic amino acid transport protein; Region: araaP; TIGR00837 640131001855 hypothetical protein; Provisional; Region: PRK10508 640131001856 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 640131001857 putative protease; Provisional; Region: PRK15447 640131001858 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 640131001859 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 640131001860 Peptidase family U32; Region: Peptidase_U32; pfam01136 640131001861 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 640131001862 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 640131001863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131001864 Coenzyme A binding pocket [chemical binding]; other site 640131001865 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 640131001866 GIY-YIG motif/motif A; other site 640131001867 putative active site [active] 640131001868 putative metal binding site [ion binding]; other site 640131001869 hypothetical protein; Provisional; Region: PRK03467 640131001870 intracellular protease, PfpI family; Region: PfpI; TIGR01382 640131001871 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 640131001872 proposed catalytic triad [active] 640131001873 conserved cys residue [active] 640131001874 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 640131001875 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 640131001876 NAD binding site [chemical binding]; other site 640131001877 active site 640131001878 Predicted permease; Region: DUF318; pfam03773 640131001879 outer membrane lipoprotein; Provisional; Region: PRK11023 640131001880 BON domain; Region: BON; pfam04972 640131001881 BON domain; Region: BON; pfam04972 640131001882 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 640131001883 dimer interface [polypeptide binding]; other site 640131001884 active site 640131001885 hypothetical protein; Reviewed; Region: PRK12497 640131001886 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 640131001887 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 640131001888 putative ligand binding site [chemical binding]; other site 640131001889 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 640131001890 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 640131001891 putative SAM binding site [chemical binding]; other site 640131001892 putative homodimer interface [polypeptide binding]; other site 640131001893 Fic family protein [Function unknown]; Region: COG3177 640131001894 Fic/DOC family; Region: Fic; pfam02661 640131001895 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 640131001896 non-specific DNA interactions [nucleotide binding]; other site 640131001897 DNA binding site [nucleotide binding] 640131001898 sequence specific DNA binding site [nucleotide binding]; other site 640131001899 putative cAMP binding site [chemical binding]; other site 640131001900 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131001901 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131001902 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131001903 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 640131001904 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 640131001905 putative NAD(P) binding site [chemical binding]; other site 640131001906 catalytic Zn binding site [ion binding]; other site 640131001907 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 640131001908 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 640131001909 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 640131001910 active site 640131001911 P-loop; other site 640131001912 phosphorylation site [posttranslational modification] 640131001913 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131001914 active site 640131001915 phosphorylation site [posttranslational modification] 640131001916 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 640131001917 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131001918 active site 640131001919 phosphorylation site [posttranslational modification] 640131001920 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 640131001921 dimerization domain swap beta strand [polypeptide binding]; other site 640131001922 regulatory protein interface [polypeptide binding]; other site 640131001923 active site 640131001924 regulatory phosphorylation site [posttranslational modification]; other site 640131001925 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 640131001926 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 640131001927 active site 640131001928 P-loop; other site 640131001929 phosphorylation site [posttranslational modification] 640131001930 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 640131001931 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 640131001932 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 640131001933 putative substrate binding site [chemical binding]; other site 640131001934 putative ATP binding site [chemical binding]; other site 640131001935 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 640131001936 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 640131001937 intersubunit interface [polypeptide binding]; other site 640131001938 active site 640131001939 zinc binding site [ion binding]; other site 640131001940 Na+ binding site [ion binding]; other site 640131001941 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131001942 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131001943 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131001944 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131001945 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 640131001946 substrate binding site [chemical binding]; other site 640131001947 ATP binding site [chemical binding]; other site 640131001948 galactarate dehydratase; Region: galactar-dH20; TIGR03248 640131001949 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 640131001950 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 640131001951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131001952 D-galactonate transporter; Region: 2A0114; TIGR00893 640131001953 putative substrate translocation pore; other site 640131001954 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 640131001955 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 640131001956 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 640131001957 glycerate kinase I; Provisional; Region: PRK10342 640131001958 tRNA_anti-like; Region: tRNA_anti-like; pfam12869 640131001959 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 640131001960 dimer interface [polypeptide binding]; other site 640131001961 Pirin-related protein [General function prediction only]; Region: COG1741 640131001962 Pirin; Region: Pirin; pfam02678 640131001963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131001964 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 640131001965 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131001966 dimerization interface [polypeptide binding]; other site 640131001967 Predicted membrane protein [Function unknown]; Region: COG3152 640131001968 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 640131001969 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 640131001970 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 640131001971 putative dimer interface [polypeptide binding]; other site 640131001972 N-terminal domain interface [polypeptide binding]; other site 640131001973 putative substrate binding pocket (H-site) [chemical binding]; other site 640131001974 Predicted membrane protein [Function unknown]; Region: COG2259 640131001975 YqjK-like protein; Region: YqjK; pfam13997 640131001976 Predicted membrane protein [Function unknown]; Region: COG5393 640131001977 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 640131001978 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 640131001979 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 640131001980 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 640131001981 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 640131001982 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 640131001983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131001984 DNA-binding site [nucleotide binding]; DNA binding site 640131001985 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 640131001986 D-galactonate transporter; Region: 2A0114; TIGR00893 640131001987 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131001988 putative substrate translocation pore; other site 640131001989 Glucuronate isomerase; Region: UxaC; pfam02614 640131001990 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 640131001991 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 640131001992 galactarate dehydratase; Region: galactar-dH20; TIGR03248 640131001993 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 640131001994 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 640131001995 serine/threonine transporter SstT; Provisional; Region: PRK13628 640131001996 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 640131001997 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 640131001998 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131001999 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131002000 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 640131002001 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 640131002002 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 640131002003 inhibitor binding site; inhibition site 640131002004 active site 640131002005 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131002006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131002007 putative symporter YagG; Provisional; Region: PRK09669 640131002008 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 640131002009 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 640131002010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131002011 S-adenosylmethionine binding site [chemical binding]; other site 640131002012 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 640131002013 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 640131002014 active site 640131002015 FMN binding site [chemical binding]; other site 640131002016 2,4-decadienoyl-CoA binding site; other site 640131002017 catalytic residue [active] 640131002018 4Fe-4S cluster binding site [ion binding]; other site 640131002019 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 640131002020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131002021 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 640131002022 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 640131002023 putative N- and C-terminal domain interface [polypeptide binding]; other site 640131002024 putative active site [active] 640131002025 putative MgATP binding site [chemical binding]; other site 640131002026 catalytic site [active] 640131002027 metal binding site [ion binding]; metal-binding site 640131002028 putative carbohydrate binding site [chemical binding]; other site 640131002029 transcriptional regulator LsrR; Provisional; Region: PRK15418 640131002030 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 640131002031 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 640131002032 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131002033 Walker A/P-loop; other site 640131002034 ATP binding site [chemical binding]; other site 640131002035 Q-loop/lid; other site 640131002036 ABC transporter signature motif; other site 640131002037 Walker B; other site 640131002038 D-loop; other site 640131002039 H-loop/switch region; other site 640131002040 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131002041 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131002042 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131002043 TM-ABC transporter signature motif; other site 640131002044 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131002045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131002046 TM-ABC transporter signature motif; other site 640131002047 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 640131002048 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 640131002049 ligand binding site [chemical binding]; other site 640131002050 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 640131002051 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 640131002052 putative active site; other site 640131002053 catalytic residue [active] 640131002054 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 640131002055 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 640131002056 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131002057 inhibitor-cofactor binding pocket; inhibition site 640131002058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002059 catalytic residue [active] 640131002060 Predicted transcriptional regulators [Transcription]; Region: COG1695 640131002061 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 640131002062 GLE1-like protein; Region: GLE1; pfam07817 640131002063 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 640131002064 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 640131002065 FAD binding pocket [chemical binding]; other site 640131002066 FAD binding motif [chemical binding]; other site 640131002067 phosphate binding motif [ion binding]; other site 640131002068 NAD binding pocket [chemical binding]; other site 640131002069 dihydroxyacetone kinase, ATP-dependent; Region: dak_ATP; TIGR02361 640131002070 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 640131002071 DAK2 domain; Region: Dak2; pfam02734 640131002072 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 640131002073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 640131002074 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 640131002075 dimerization domain swap beta strand [polypeptide binding]; other site 640131002076 regulatory protein interface [polypeptide binding]; other site 640131002077 active site 640131002078 regulatory phosphorylation site [posttranslational modification]; other site 640131002079 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 640131002080 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 640131002081 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 640131002082 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 640131002083 Dak1 domain; Region: Dak1; pfam02733 640131002084 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 640131002085 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 640131002086 dimer interface [polypeptide binding]; other site 640131002087 active site 640131002088 metal binding site [ion binding]; metal-binding site 640131002089 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 640131002090 PAS domain; Region: PAS; smart00091 640131002091 putative active site [active] 640131002092 heme pocket [chemical binding]; other site 640131002093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131002094 Walker A motif; other site 640131002095 ATP binding site [chemical binding]; other site 640131002096 Walker B motif; other site 640131002097 arginine finger; other site 640131002098 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131002099 acid-resistance protein; Provisional; Region: hdeB; PRK11566 640131002100 acid-resistance membrane protein; Provisional; Region: PRK10209 640131002101 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 640131002102 hypothetical protein; Provisional; Region: PRK10316 640131002103 YfdX protein; Region: YfdX; pfam10938 640131002104 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 640131002105 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131002106 substrate binding pocket [chemical binding]; other site 640131002107 membrane-bound complex binding site; other site 640131002108 hinge residues; other site 640131002109 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131002110 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131002111 substrate binding pocket [chemical binding]; other site 640131002112 membrane-bound complex binding site; other site 640131002113 hinge residues; other site 640131002114 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 640131002115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131002116 dimer interface [polypeptide binding]; other site 640131002117 phosphorylation site [posttranslational modification] 640131002118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131002119 ATP binding site [chemical binding]; other site 640131002120 Mg2+ binding site [ion binding]; other site 640131002121 G-X-G motif; other site 640131002122 Response regulator receiver domain; Region: Response_reg; pfam00072 640131002123 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131002124 active site 640131002125 phosphorylation site [posttranslational modification] 640131002126 intermolecular recognition site; other site 640131002127 dimerization interface [polypeptide binding]; other site 640131002128 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 640131002129 putative binding surface; other site 640131002130 active site 640131002131 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 640131002132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131002133 active site 640131002134 phosphorylation site [posttranslational modification] 640131002135 intermolecular recognition site; other site 640131002136 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131002137 DNA binding residues [nucleotide binding] 640131002138 dimerization interface [polypeptide binding]; other site 640131002139 HdeA/HdeB family; Region: HdeA; pfam06411 640131002140 Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237 640131002141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 640131002142 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 640131002143 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 640131002144 active site 640131002145 SUMO-1 interface [polypeptide binding]; other site 640131002146 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 640131002147 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 640131002148 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 640131002149 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 640131002150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 640131002151 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 640131002152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 640131002153 DNA binding residues [nucleotide binding] 640131002154 DNA primase; Validated; Region: dnaG; PRK05667 640131002155 CHC2 zinc finger; Region: zf-CHC2; pfam01807 640131002156 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 640131002157 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 640131002158 active site 640131002159 metal binding site [ion binding]; metal-binding site 640131002160 interdomain interaction site; other site 640131002161 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 640131002162 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 640131002163 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 640131002164 UGMP family protein; Validated; Region: PRK09604 640131002165 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 640131002166 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 640131002167 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 640131002168 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131002169 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 640131002170 UreF; Region: UreF; pfam01730 640131002171 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 640131002172 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 640131002173 dimer interface [polypeptide binding]; other site 640131002174 catalytic residues [active] 640131002175 urease subunit alpha; Reviewed; Region: ureC; PRK13207 640131002176 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 640131002177 subunit interactions [polypeptide binding]; other site 640131002178 active site 640131002179 flap region; other site 640131002180 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 640131002181 gamma-beta subunit interface [polypeptide binding]; other site 640131002182 alpha-beta subunit interface [polypeptide binding]; other site 640131002183 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 640131002184 alpha-gamma subunit interface [polypeptide binding]; other site 640131002185 beta-gamma subunit interface [polypeptide binding]; other site 640131002186 UreD urease accessory protein; Region: UreD; cl00530 640131002187 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 640131002188 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 640131002189 homooctamer interface [polypeptide binding]; other site 640131002190 active site 640131002191 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 640131002192 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 640131002193 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 640131002194 active site 640131002195 NTP binding site [chemical binding]; other site 640131002196 metal binding triad [ion binding]; metal-binding site 640131002197 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 640131002198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131002199 Zn2+ binding site [ion binding]; other site 640131002200 Mg2+ binding site [ion binding]; other site 640131002201 SH3 domain-containing protein; Provisional; Region: PRK10884 640131002202 Bacterial SH3 domain homologues; Region: SH3b; smart00287 640131002203 Uncharacterized conserved protein [Function unknown]; Region: COG3025 640131002204 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 640131002205 putative active site [active] 640131002206 putative metal binding residues [ion binding]; other site 640131002207 signature motif; other site 640131002208 putative triphosphate binding site [ion binding]; other site 640131002209 CHAD domain; Region: CHAD; pfam05235 640131002210 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 640131002211 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 640131002212 metal binding triad; other site 640131002213 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 640131002214 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 640131002215 metal binding triad; other site 640131002216 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 640131002217 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 640131002218 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 640131002219 putative ribose interaction site [chemical binding]; other site 640131002220 putative ADP binding site [chemical binding]; other site 640131002221 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 640131002222 active site 640131002223 nucleotide binding site [chemical binding]; other site 640131002224 HIGH motif; other site 640131002225 KMSKS motif; other site 640131002226 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 640131002227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 640131002228 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 640131002229 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 640131002230 zinc transporter ZupT; Provisional; Region: PRK04201 640131002231 ZIP Zinc transporter; Region: Zip; pfam02535 640131002232 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 640131002233 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 640131002234 putative active site [active] 640131002235 metal binding site [ion binding]; metal-binding site 640131002236 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 640131002237 hypothetical protein; Provisional; Region: PRK11653 640131002238 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 640131002239 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 640131002240 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 640131002241 dimer interface [polypeptide binding]; other site 640131002242 ADP-ribose binding site [chemical binding]; other site 640131002243 active site 640131002244 nudix motif; other site 640131002245 metal binding site [ion binding]; metal-binding site 640131002246 putative dehydrogenase; Provisional; Region: PRK11039 640131002247 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 640131002248 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 640131002249 active site 640131002250 metal binding site [ion binding]; metal-binding site 640131002251 hexamer interface [polypeptide binding]; other site 640131002252 esterase YqiA; Provisional; Region: PRK11071 640131002253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 640131002254 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 640131002255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131002256 ATP binding site [chemical binding]; other site 640131002257 Mg2+ binding site [ion binding]; other site 640131002258 G-X-G motif; other site 640131002259 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 640131002260 anchoring element; other site 640131002261 dimer interface [polypeptide binding]; other site 640131002262 ATP binding site [chemical binding]; other site 640131002263 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 640131002264 active site 640131002265 metal binding site [ion binding]; metal-binding site 640131002266 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 640131002267 Uncharacterized conserved protein [Function unknown]; Region: COG1359 640131002268 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 640131002269 sensor protein QseC; Provisional; Region: PRK10337 640131002270 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131002271 dimer interface [polypeptide binding]; other site 640131002272 phosphorylation site [posttranslational modification] 640131002273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131002274 ATP binding site [chemical binding]; other site 640131002275 Mg2+ binding site [ion binding]; other site 640131002276 G-X-G motif; other site 640131002277 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 640131002278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131002279 active site 640131002280 phosphorylation site [posttranslational modification] 640131002281 intermolecular recognition site; other site 640131002282 dimerization interface [polypeptide binding]; other site 640131002283 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131002284 DNA binding site [nucleotide binding] 640131002285 TIGR00156 family protein; Region: TIGR00156 640131002286 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131002287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131002288 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 640131002289 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 640131002290 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 640131002291 CAP-like domain; other site 640131002292 active site 640131002293 primary dimer interface [polypeptide binding]; other site 640131002294 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 640131002295 putative acyl-acceptor binding pocket; other site 640131002296 FtsI repressor; Provisional; Region: PRK10883 640131002297 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 640131002298 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 640131002299 hypothetical protein; Provisional; Region: PRK01254 640131002300 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 640131002301 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 640131002302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131002303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131002304 active site 640131002305 catalytic tetrad [active] 640131002306 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 640131002307 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 640131002308 dimer interface [polypeptide binding]; other site 640131002309 active site 640131002310 metal binding site [ion binding]; metal-binding site 640131002311 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 640131002312 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131002313 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131002314 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131002315 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 640131002316 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 640131002317 cystathionine beta-lyase; Provisional; Region: PRK08114 640131002318 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 640131002319 homodimer interface [polypeptide binding]; other site 640131002320 substrate-cofactor binding pocket; other site 640131002321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002322 catalytic residue [active] 640131002323 biopolymer transport protein ExbB; Provisional; Region: PRK10414 640131002324 biopolymer transport protein ExbD; Provisional; Region: PRK11267 640131002325 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 640131002326 hypothetical protein; Provisional; Region: PRK05208 640131002327 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 640131002328 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 640131002329 putative S-transferase; Provisional; Region: PRK11752 640131002330 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 640131002331 C-terminal domain interface [polypeptide binding]; other site 640131002332 GSH binding site (G-site) [chemical binding]; other site 640131002333 dimer interface [polypeptide binding]; other site 640131002334 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 640131002335 dimer interface [polypeptide binding]; other site 640131002336 N-terminal domain interface [polypeptide binding]; other site 640131002337 active site 640131002338 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 640131002339 Thioredoxin; Region: Thioredoxin_4; cl17273 640131002340 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 640131002341 CHAP domain; Region: CHAP; pfam05257 640131002342 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 640131002343 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 640131002344 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131002345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002346 homodimer interface [polypeptide binding]; other site 640131002347 catalytic residue [active] 640131002348 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 640131002349 putative NAD(P) binding site [chemical binding]; other site 640131002350 homodimer interface [polypeptide binding]; other site 640131002351 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131002352 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131002353 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 640131002354 putative effector binding pocket; other site 640131002355 putative dimerization interface [polypeptide binding]; other site 640131002356 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 640131002357 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 640131002358 homodimer interface [polypeptide binding]; other site 640131002359 substrate-cofactor binding pocket; other site 640131002360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002361 catalytic residue [active] 640131002362 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 640131002363 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 640131002364 dimer interface [polypeptide binding]; other site 640131002365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002366 catalytic residue [active] 640131002367 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 640131002368 FOG: CBS domain [General function prediction only]; Region: COG0517 640131002369 Protein of unknown function (DUF554); Region: DUF554; pfam04474 640131002370 ornithine decarboxylase; Provisional; Region: PRK13578 640131002371 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 640131002372 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 640131002373 homodimer interface [polypeptide binding]; other site 640131002374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002375 catalytic residue [active] 640131002376 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 640131002377 nucleoside transporter; Region: 2A0110; TIGR00889 640131002378 murein transglycosylase C; Provisional; Region: mltC; PRK11671 640131002379 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 640131002380 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131002381 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131002382 catalytic residue [active] 640131002383 oxidative damage protection protein; Provisional; Region: PRK05408 640131002384 adenine DNA glycosylase; Provisional; Region: PRK10880 640131002385 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 640131002386 minor groove reading motif; other site 640131002387 helix-hairpin-helix signature motif; other site 640131002388 substrate binding pocket [chemical binding]; other site 640131002389 active site 640131002390 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 640131002391 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 640131002392 DNA binding and oxoG recognition site [nucleotide binding] 640131002393 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 640131002394 hypothetical protein; Provisional; Region: PRK11702 640131002395 hypothetical protein; Provisional; Region: PRK10626 640131002396 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 640131002397 HemN family oxidoreductase; Provisional; Region: PRK05660 640131002398 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131002399 FeS/SAM binding site; other site 640131002400 HemN C-terminal domain; Region: HemN_C; pfam06969 640131002401 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 640131002402 active site 640131002403 dimerization interface [polypeptide binding]; other site 640131002404 hypothetical protein; Validated; Region: PRK05090 640131002405 YGGT family; Region: YGGT; pfam02325 640131002406 YGGT family; Region: YGGT; pfam02325 640131002407 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 640131002408 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 640131002409 catalytic residue [active] 640131002410 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 640131002411 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 640131002412 Walker A motif; other site 640131002413 ATP binding site [chemical binding]; other site 640131002414 Walker B motif; other site 640131002415 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 640131002416 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131002417 DNA binding residues [nucleotide binding] 640131002418 dimerization interface [polypeptide binding]; other site 640131002419 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 640131002420 hypothetical protein; Validated; Region: PRK00228 640131002421 glutathione synthetase; Provisional; Region: PRK05246 640131002422 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 640131002423 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 640131002424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 640131002425 RNA methyltransferase, RsmE family; Region: TIGR00046 640131002426 DNA-specific endonuclease I; Provisional; Region: PRK15137 640131002427 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 640131002428 hypothetical protein; Provisional; Region: PRK04860 640131002429 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 640131002430 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 640131002431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002432 putative substrate translocation pore; other site 640131002433 Bacterial protein of unknown function (DUF899); Region: DUF899; cl17828 640131002434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002435 S-adenosylmethionine synthetase; Validated; Region: PRK05250 640131002436 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 640131002437 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 640131002438 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 640131002439 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 640131002440 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 640131002441 dimer interface [polypeptide binding]; other site 640131002442 active site 640131002443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 640131002444 catalytic residues [active] 640131002445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 640131002446 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 640131002447 agmatinase; Region: agmatinase; TIGR01230 640131002448 oligomer interface [polypeptide binding]; other site 640131002449 putative active site [active] 640131002450 Mn binding site [ion binding]; other site 640131002451 outer membrane porin, OprD family; Region: OprD; pfam03573 640131002452 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 640131002453 transketolase; Reviewed; Region: PRK12753 640131002454 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 640131002455 TPP-binding site [chemical binding]; other site 640131002456 dimer interface [polypeptide binding]; other site 640131002457 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 640131002458 PYR/PP interface [polypeptide binding]; other site 640131002459 dimer interface [polypeptide binding]; other site 640131002460 TPP binding site [chemical binding]; other site 640131002461 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131002462 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 640131002463 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 640131002464 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 640131002465 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 640131002466 Phosphoglycerate kinase; Region: PGK; pfam00162 640131002467 substrate binding site [chemical binding]; other site 640131002468 hinge regions; other site 640131002469 ADP binding site [chemical binding]; other site 640131002470 catalytic site [active] 640131002471 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 640131002472 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 640131002473 active site 640131002474 intersubunit interface [polypeptide binding]; other site 640131002475 zinc binding site [ion binding]; other site 640131002476 Na+ binding site [ion binding]; other site 640131002477 mechanosensitive channel MscS; Provisional; Region: PRK10334 640131002478 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131002479 arginine exporter protein; Provisional; Region: PRK09304 640131002480 oxidative stress defense protein; Provisional; Region: PRK11087 640131002481 Uncharacterized conserved protein [Function unknown]; Region: COG2968 640131002482 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 640131002483 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131002484 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 640131002485 putative dimerization interface [polypeptide binding]; other site 640131002486 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 640131002487 tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131002488 active site 640131002489 dimer interface [polypeptide binding]; other site 640131002490 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 640131002491 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 640131002492 ligand binding site [chemical binding]; other site 640131002493 NAD binding site [chemical binding]; other site 640131002494 tetramer interface [polypeptide binding]; other site 640131002495 catalytic site [active] 640131002496 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 640131002497 L-serine binding site [chemical binding]; other site 640131002498 ACT domain interface; other site 640131002499 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 640131002500 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 640131002501 Z-ring-associated protein; Provisional; Region: PRK10972 640131002502 hypothetical protein; Reviewed; Region: PRK01736 640131002503 proline aminopeptidase P II; Provisional; Region: PRK10879 640131002504 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 640131002505 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 640131002506 active site 640131002507 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 640131002508 2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984 640131002509 oxidoreductase; Provisional; Region: PRK08013 640131002510 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 640131002511 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 640131002512 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 640131002513 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 640131002514 lipoyl attachment site [posttranslational modification]; other site 640131002515 glycine dehydrogenase; Provisional; Region: PRK05367 640131002516 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 640131002517 tetramer interface [polypeptide binding]; other site 640131002518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002519 catalytic residue [active] 640131002520 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 640131002521 tetramer interface [polypeptide binding]; other site 640131002522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002523 catalytic residue [active] 640131002524 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 640131002525 classical (c) SDRs; Region: SDR_c; cd05233 640131002526 NAD(P) binding site [chemical binding]; other site 640131002527 active site 640131002528 TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011 640131002529 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 640131002530 catalytic residues [active] 640131002531 conjugal transfer protein TrbB; Provisional; Region: PRK13728; cl17283 640131002532 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 640131002533 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 640131002534 catalytic residues [active] 640131002535 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 640131002536 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 640131002537 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 640131002538 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 640131002539 DsbD alpha interface [polypeptide binding]; other site 640131002540 catalytic residues [active] 640131002541 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 640131002542 beta-galactosidase; Region: BGL; TIGR03356 640131002543 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 640131002544 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131002545 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 640131002546 putative active site [active] 640131002547 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 640131002548 hemolysin; Provisional; Region: PRK15087 640131002549 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 640131002550 putative global regulator; Reviewed; Region: PRK09559 640131002551 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 640131002552 hypothetical protein; Provisional; Region: PRK10878 640131002553 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 640131002554 flavodoxin FldB; Provisional; Region: PRK12359 640131002555 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 640131002556 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 640131002557 active site 640131002558 Int/Topo IB signature motif; other site 640131002559 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 640131002560 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 640131002561 dimerization domain [polypeptide binding]; other site 640131002562 dimer interface [polypeptide binding]; other site 640131002563 catalytic residues [active] 640131002564 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 640131002565 DHH family; Region: DHH; pfam01368 640131002566 DHHA1 domain; Region: DHHA1; pfam02272 640131002567 peptide chain release factor 2; Validated; Region: prfB; PRK00578 640131002568 This domain is found in peptide chain release factors; Region: PCRF; smart00937 640131002569 RF-1 domain; Region: RF-1; pfam00472 640131002570 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 640131002571 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 640131002572 dimer interface [polypeptide binding]; other site 640131002573 putative anticodon binding site; other site 640131002574 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 640131002575 motif 1; other site 640131002576 active site 640131002577 motif 2; other site 640131002578 motif 3; other site 640131002579 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 640131002580 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 640131002581 active site 640131002582 metal binding site [ion binding]; metal-binding site 640131002583 nudix motif; other site 640131002584 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 640131002585 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131002586 Peptidase family M23; Region: Peptidase_M23; pfam01551 640131002587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002588 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131002589 putative substrate translocation pore; other site 640131002590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131002591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131002592 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 640131002593 putative substrate binding pocket [chemical binding]; other site 640131002594 putative dimerization interface [polypeptide binding]; other site 640131002595 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 640131002596 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 640131002597 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131002598 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131002599 active site 640131002600 catalytic tetrad [active] 640131002601 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 640131002602 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131002603 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131002604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131002605 dimerization interface [polypeptide binding]; other site 640131002606 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 640131002607 YCII-related domain; Region: YCII; cl00999 640131002608 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131002609 dimerization interface [polypeptide binding]; other site 640131002610 putative DNA binding site [nucleotide binding]; other site 640131002611 putative Zn2+ binding site [ion binding]; other site 640131002612 arsenical pump membrane protein; Provisional; Region: PRK15445 640131002613 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 640131002614 transmembrane helices; other site 640131002615 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 640131002616 ArsC family; Region: ArsC; pfam03960 640131002617 catalytic residues [active] 640131002618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002619 putative substrate translocation pore; other site 640131002620 POT family; Region: PTR2; cl17359 640131002621 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 640131002622 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 640131002623 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 640131002624 multidrug resistance protein MdtN; Provisional; Region: PRK10476 640131002625 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131002626 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131002627 Uncharacterized conserved protein [Function unknown]; Region: COG3592 640131002628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131002629 Coenzyme A binding pocket [chemical binding]; other site 640131002630 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131002631 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 640131002632 mannosyl binding site [chemical binding]; other site 640131002633 Fimbrial protein; Region: Fimbrial; cl01416 640131002634 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131002635 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131002636 outer membrane usher protein; Provisional; Region: PRK15193 640131002637 PapC N-terminal domain; Region: PapC_N; pfam13954 640131002638 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131002639 PapC C-terminal domain; Region: PapC_C; pfam13953 640131002640 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 640131002641 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131002642 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131002643 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131002644 Fimbrial protein; Region: Fimbrial; cl01416 640131002645 tyrosine recombinase; Provisional; Region: PRK09871 640131002646 active site 640131002647 DNA binding site [nucleotide binding] 640131002648 Int/Topo IB signature motif; other site 640131002649 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 640131002650 Int/Topo IB signature motif; other site 640131002651 fimbrial chaperone protein; Provisional; Region: PRK15220 640131002652 fimbrial chaperone protein PegB; Provisional; Region: PRK15218 640131002653 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131002654 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131002655 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 640131002656 PapC N-terminal domain; Region: PapC_N; pfam13954 640131002657 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131002658 PapC C-terminal domain; Region: PapC_C; pfam13953 640131002659 Fimbrial protein; Region: Fimbrial; pfam00419 640131002660 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215 640131002661 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131002662 MarR family; Region: MarR; pfam01047 640131002663 MarR family; Region: MarR_2; cl17246 640131002664 EamA-like transporter family; Region: EamA; pfam00892 640131002665 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 640131002666 EamA-like transporter family; Region: EamA; pfam00892 640131002667 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131002668 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131002669 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131002670 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131002671 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131002672 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131002673 PapC N-terminal domain; Region: PapC_N; pfam13954 640131002674 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131002675 PapC C-terminal domain; Region: PapC_C; pfam13953 640131002676 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131002677 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131002678 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131002679 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131002680 DNA binding residues [nucleotide binding] 640131002681 PilZ domain; Region: PilZ; pfam07238 640131002682 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131002683 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131002684 active site 640131002685 catalytic tetrad [active] 640131002686 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 640131002687 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 640131002688 Predicted membrane protein [Function unknown]; Region: COG4125 640131002689 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 640131002690 Bacterial Transmembrane Pair family; Region: BTP; pfam05232 640131002691 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131002692 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131002693 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131002694 dimerization interface [polypeptide binding]; other site 640131002695 putative acyltransferase; Provisional; Region: PRK05790 640131002696 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131002697 dimer interface [polypeptide binding]; other site 640131002698 active site 640131002699 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 640131002700 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 640131002701 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 640131002702 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 640131002703 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 640131002704 NADP binding site [chemical binding]; other site 640131002705 homodimer interface [polypeptide binding]; other site 640131002706 active site 640131002707 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 640131002708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002709 putative substrate translocation pore; other site 640131002710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131002712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131002713 DNA binding site [nucleotide binding] 640131002714 domain linker motif; other site 640131002715 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 640131002716 putative dimerization interface [polypeptide binding]; other site 640131002717 putative ligand binding site [chemical binding]; other site 640131002718 galactoside permease; Reviewed; Region: lacY; PRK09528 640131002719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002720 putative substrate translocation pore; other site 640131002721 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 640131002722 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 640131002723 substrate binding [chemical binding]; other site 640131002724 active site 640131002725 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 640131002726 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 640131002727 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 640131002728 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 640131002729 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 640131002730 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131002731 Walker A/P-loop; other site 640131002732 ATP binding site [chemical binding]; other site 640131002733 Q-loop/lid; other site 640131002734 ABC transporter signature motif; other site 640131002735 Walker B; other site 640131002736 D-loop; other site 640131002737 H-loop/switch region; other site 640131002738 TOBE domain; Region: TOBE; pfam03459 640131002739 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131002740 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131002741 dimer interface [polypeptide binding]; other site 640131002742 conserved gate region; other site 640131002743 putative PBP binding loops; other site 640131002744 ABC-ATPase subunit interface; other site 640131002745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131002746 dimer interface [polypeptide binding]; other site 640131002747 conserved gate region; other site 640131002748 putative PBP binding loops; other site 640131002749 ABC-ATPase subunit interface; other site 640131002750 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 640131002751 putative racemase; Provisional; Region: PRK10200 640131002752 aspartate racemase; Region: asp_race; TIGR00035 640131002753 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 640131002754 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131002755 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131002756 dimerization interface [polypeptide binding]; other site 640131002757 diaminopimelate decarboxylase; Provisional; Region: PRK11165 640131002758 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 640131002759 active site 640131002760 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 640131002761 substrate binding site [chemical binding]; other site 640131002762 catalytic residues [active] 640131002763 dimer interface [polypeptide binding]; other site 640131002764 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131002765 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131002766 DNA binding site [nucleotide binding] 640131002767 domain linker motif; other site 640131002768 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 640131002769 dimerization interface (closed form) [polypeptide binding]; other site 640131002770 ligand binding site [chemical binding]; other site 640131002771 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 640131002772 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 640131002773 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 640131002774 beta-galactosidase; Region: BGL; TIGR03356 640131002775 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 640131002776 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131002777 DNA-binding site [nucleotide binding]; DNA binding site 640131002778 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 640131002779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131002780 Coenzyme A binding pocket [chemical binding]; other site 640131002781 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 640131002782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131002783 DNA binding site [nucleotide binding] 640131002784 domain linker motif; other site 640131002785 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 640131002786 dimerization interface (closed form) [polypeptide binding]; other site 640131002787 ligand binding site [chemical binding]; other site 640131002788 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 640131002789 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 640131002790 putative acyl-acceptor binding pocket; other site 640131002791 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 640131002792 acyl-activating enzyme (AAE) consensus motif; other site 640131002793 putative AMP binding site [chemical binding]; other site 640131002794 lysophospholipid transporter LplT; Provisional; Region: PRK11195 640131002795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131002796 putative substrate translocation pore; other site 640131002797 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131002798 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131002799 active site 640131002800 catalytic tetrad [active] 640131002801 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 640131002802 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 640131002803 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 640131002804 putative DNA-binding cleft [nucleotide binding]; other site 640131002805 putative DNA clevage site; other site 640131002806 molecular lever; other site 640131002807 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 640131002808 putative active site [active] 640131002809 Ap4A binding site [chemical binding]; other site 640131002810 nudix motif; other site 640131002811 putative metal binding site [ion binding]; other site 640131002812 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 640131002813 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 640131002814 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 640131002815 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 640131002816 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 640131002817 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 640131002818 thymidylate synthase; Reviewed; Region: thyA; PRK01827 640131002819 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 640131002820 dimerization interface [polypeptide binding]; other site 640131002821 active site 640131002822 hypothetical protein; Provisional; Region: PRK10506 640131002823 hypothetical protein; Provisional; Region: PRK10557 640131002824 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 640131002825 hypothetical protein; Provisional; Region: PRK11521 640131002826 hypothetical protein; Provisional; Region: PRK10332 640131002827 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 640131002828 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 640131002829 Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330 640131002830 protease3; Provisional; Region: PRK15101 640131002831 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 640131002832 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 640131002833 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 640131002834 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 640131002835 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 640131002836 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 640131002837 Family description; Region: UvrD_C_2; pfam13538 640131002838 N-acetylglutamate synthase; Validated; Region: PRK05279 640131002839 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 640131002840 putative feedback inhibition sensing region; other site 640131002841 putative nucleotide binding site [chemical binding]; other site 640131002842 putative substrate binding site [chemical binding]; other site 640131002843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131002844 Coenzyme A binding pocket [chemical binding]; other site 640131002845 AMIN domain; Region: AMIN; pfam11741 640131002846 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 640131002847 active site 640131002848 metal binding site [ion binding]; metal-binding site 640131002849 threonine-phosphate decarboxylase; Provisional; Region: PRK08056 640131002850 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131002851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131002852 homodimer interface [polypeptide binding]; other site 640131002853 catalytic residue [active] 640131002854 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 640131002855 propionate kinase; Reviewed; Region: PRK12397 640131002856 propionate/acetate kinase; Provisional; Region: PRK12379 640131002857 Ethanolamine utilisation - propanediol utilisation; Region: PduV-EutP; pfam10662 640131002858 G3 box; other site 640131002859 Switch II region; other site 640131002860 GTP/Mg2+ binding site [chemical binding]; other site 640131002861 G4 box; other site 640131002862 G5 box; other site 640131002863 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 640131002864 putative hexamer interface [polypeptide binding]; other site 640131002865 putative hexagonal pore; other site 640131002866 PduT-like ethanolamine utilization protein; Region: eut_PduT; TIGR02526 640131002867 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053 640131002868 putative hexamer interface [polypeptide binding]; other site 640131002869 putative hexagonal pore; other site 640131002870 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 640131002871 catalytic site [active] 640131002872 1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054 640131002873 putative hexamer interface [polypeptide binding]; other site 640131002874 putative hexagonal pore; other site 640131002875 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 640131002876 SLBB domain; Region: SLBB; pfam10531 640131002877 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 640131002878 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 640131002879 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 640131002880 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 640131002881 active site 640131002882 NAD binding site [chemical binding]; other site 640131002883 metal binding site [ion binding]; metal-binding site 640131002884 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 640131002885 putative catalytic cysteine [active] 640131002886 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 640131002887 Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193 640131002888 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 640131002889 Hexamer/Pentamer interface [polypeptide binding]; other site 640131002890 central pore; other site 640131002891 putative propanediol utilization protein PduM; Provisional; Region: PRK15428 640131002892 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 640131002893 Propanediol utilisation protein PduL; Region: PduL; pfam06130 640131002894 Propanediol utilisation protein PduL; Region: PduL; pfam06130 640131002895 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131002896 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 640131002897 Hexamer interface [polypeptide binding]; other site 640131002898 Hexagonal pore residue; other site 640131002899 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131002900 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 640131002901 Hexamer interface [polypeptide binding]; other site 640131002902 Putative hexagonal pore residue; other site 640131002903 Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288 640131002904 Cell division protein FtsA; Region: FtsA; cl17206 640131002905 Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841 640131002906 propanediol dehydratase small subunit; Provisional; Region: pduE; PRK15443 640131002907 propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042 640131002908 Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909 640131002909 Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687 640131002910 alpha-alpha subunit/dimer interface [polypeptide binding]; other site 640131002911 alpha-beta subunit interface [polypeptide binding]; other site 640131002912 alpha-gamma subunit interface [polypeptide binding]; other site 640131002913 active site 640131002914 substrate and K+ binding site; other site 640131002915 K+ binding site [ion binding]; other site 640131002916 cobalamin binding site [chemical binding]; other site 640131002917 propanediol utilization protein PduB; Provisional; Region: PRK15415 640131002918 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 640131002919 putative hexamer interface [polypeptide binding]; other site 640131002920 putative hexagonal pore; other site 640131002921 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 640131002922 putative hexamer interface [polypeptide binding]; other site 640131002923 putative hexagonal pore; other site 640131002924 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131002925 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 640131002926 Hexamer interface [polypeptide binding]; other site 640131002927 Putative hexagonal pore residue; other site 640131002928 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 640131002929 amphipathic channel; other site 640131002930 Asn-Pro-Ala signature motifs; other site 640131002931 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 640131002932 Sensory domain found in PocR; Region: PocR; pfam10114 640131002933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131002934 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131002935 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131002936 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 640131002937 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 640131002938 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 640131002939 catalytic triad [active] 640131002940 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 640131002941 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; PRK08286 640131002942 Precorrin-8X methylmutase; Region: CbiC; pfam02570 640131002943 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 640131002944 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 640131002945 active site 640131002946 putative homodimer interface [polypeptide binding]; other site 640131002947 SAM binding site [chemical binding]; other site 640131002948 cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287 640131002949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131002950 S-adenosylmethionine binding site [chemical binding]; other site 640131002951 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 640131002952 active site 640131002953 SAM binding site [chemical binding]; other site 640131002954 homodimer interface [polypeptide binding]; other site 640131002955 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 640131002956 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 640131002957 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 640131002958 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 640131002959 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 640131002960 active site 640131002961 SAM binding site [chemical binding]; other site 640131002962 homodimer interface [polypeptide binding]; other site 640131002963 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 640131002964 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 640131002965 Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822 640131002966 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_N; cd03412 640131002967 active site 640131002968 C-terminal domain interface [polypeptide binding]; other site 640131002969 Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413 640131002970 active site 640131002971 N-terminal domain interface [polypeptide binding]; other site 640131002972 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 640131002973 active site 640131002974 SAM binding site [chemical binding]; other site 640131002975 homodimer interface [polypeptide binding]; other site 640131002976 cobalt transport protein CbiM; Validated; Region: PRK08319 640131002977 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 640131002978 cobalt transport protein CbiN; Provisional; Region: PRK02898 640131002979 cobalt transport protein CbiQ; Provisional; Region: PRK15485 640131002980 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13638 640131002981 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 640131002982 Walker A/P-loop; other site 640131002983 ATP binding site [chemical binding]; other site 640131002984 Q-loop/lid; other site 640131002985 ABC transporter signature motif; other site 640131002986 Walker B; other site 640131002987 D-loop; other site 640131002988 H-loop/switch region; other site 640131002989 cobyric acid synthase; Provisional; Region: PRK00784 640131002990 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131002991 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131002992 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 640131002993 catalytic triad [active] 640131002994 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 640131002995 homotrimer interface [polypeptide binding]; other site 640131002996 Walker A motif; other site 640131002997 GTP binding site [chemical binding]; other site 640131002998 Walker B motif; other site 640131002999 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 640131003000 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 640131003001 putative dimer interface [polypeptide binding]; other site 640131003002 active site pocket [active] 640131003003 putative cataytic base [active] 640131003004 murein transglycosylase A; Provisional; Region: mltA; PRK11162 640131003005 MltA specific insert domain; Region: MltA; pfam03562 640131003006 3D domain; Region: 3D; pfam06725 640131003007 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 640131003008 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 640131003009 putative ATP binding site [chemical binding]; other site 640131003010 putative substrate interface [chemical binding]; other site 640131003011 Fe-S metabolism associated domain; Region: SufE; cl00951 640131003012 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 640131003013 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 640131003014 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131003015 catalytic residue [active] 640131003016 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 640131003017 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 640131003018 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003019 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 640131003020 dimerization interface [polypeptide binding]; other site 640131003021 substrate binding pocket [chemical binding]; other site 640131003022 hypothetical protein; Provisional; Region: PRK10873 640131003023 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 640131003024 FtsJ-like methyltransferase; Region: FtsJ; cl17430 640131003025 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 640131003026 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131003027 DNA-binding site [nucleotide binding]; DNA binding site 640131003028 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131003029 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 640131003030 L-fuculokinase; Provisional; Region: PRK10331 640131003031 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 640131003032 nucleotide binding site [chemical binding]; other site 640131003033 L-fucose isomerase; Provisional; Region: fucI; PRK10991 640131003034 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 640131003035 hexamer (dimer of trimers) interface [polypeptide binding]; other site 640131003036 trimer interface [polypeptide binding]; other site 640131003037 substrate binding site [chemical binding]; other site 640131003038 Mn binding site [ion binding]; other site 640131003039 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 640131003040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003041 putative substrate translocation pore; other site 640131003042 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 640131003043 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 640131003044 intersubunit interface [polypeptide binding]; other site 640131003045 active site 640131003046 Zn2+ binding site [ion binding]; other site 640131003047 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 640131003048 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 640131003049 dimer interface [polypeptide binding]; other site 640131003050 active site 640131003051 metal binding site [ion binding]; metal-binding site 640131003052 flap endonuclease-like protein; Provisional; Region: PRK09482 640131003053 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 640131003054 active site 640131003055 metal binding site 1 [ion binding]; metal-binding site 640131003056 putative 5' ssDNA interaction site; other site 640131003057 metal binding site 3; metal-binding site 640131003058 metal binding site 2 [ion binding]; metal-binding site 640131003059 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 640131003060 putative DNA binding site [nucleotide binding]; other site 640131003061 putative metal binding site [ion binding]; other site 640131003062 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 640131003063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003064 Walker A motif; other site 640131003065 ATP binding site [chemical binding]; other site 640131003066 Walker B motif; other site 640131003067 arginine finger; other site 640131003068 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131003069 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 640131003070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131003071 substrate binding pocket [chemical binding]; other site 640131003072 membrane-bound complex binding site; other site 640131003073 hinge residues; other site 640131003074 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 640131003075 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 640131003076 active site 640131003077 dimer interface [polypeptide binding]; other site 640131003078 non-prolyl cis peptide bond; other site 640131003079 insertion regions; other site 640131003080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 640131003081 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 640131003082 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 640131003083 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 640131003084 active site 640131003085 non-prolyl cis peptide bond; other site 640131003086 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 640131003087 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 640131003088 Walker A/P-loop; other site 640131003089 ATP binding site [chemical binding]; other site 640131003090 Q-loop/lid; other site 640131003091 ABC transporter signature motif; other site 640131003092 Walker B; other site 640131003093 D-loop; other site 640131003094 H-loop/switch region; other site 640131003095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131003096 dimer interface [polypeptide binding]; other site 640131003097 conserved gate region; other site 640131003098 ABC-ATPase subunit interface; other site 640131003099 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 640131003100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003101 putative substrate translocation pore; other site 640131003102 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 640131003103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003104 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 640131003105 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 640131003106 Flavin binding site [chemical binding]; other site 640131003107 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 640131003108 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131003109 substrate binding pocket [chemical binding]; other site 640131003110 membrane-bound complex binding site; other site 640131003111 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 640131003112 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 640131003113 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 640131003114 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 640131003115 serine transporter; Region: stp; TIGR00814 640131003116 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 640131003117 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 640131003118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 640131003119 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 640131003120 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 640131003121 SecY interacting protein Syd; Provisional; Region: PRK04968 640131003122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 640131003123 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 640131003124 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 640131003125 probable active site [active] 640131003126 flavodoxin; Provisional; Region: PRK08105 640131003127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003128 D-galactonate transporter; Region: 2A0114; TIGR00893 640131003129 putative substrate translocation pore; other site 640131003130 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 640131003131 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 640131003132 active site 640131003133 tetramer interface [polypeptide binding]; other site 640131003134 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 640131003135 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 640131003136 active site 640131003137 tetramer interface [polypeptide binding]; other site 640131003138 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 640131003139 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 640131003140 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 640131003141 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131003142 dimerization interface [polypeptide binding]; other site 640131003143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131003144 dimer interface [polypeptide binding]; other site 640131003145 phosphorylation site [posttranslational modification] 640131003146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131003147 ATP binding site [chemical binding]; other site 640131003148 Mg2+ binding site [ion binding]; other site 640131003149 G-X-G motif; other site 640131003150 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 640131003151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131003152 active site 640131003153 phosphorylation site [posttranslational modification] 640131003154 intermolecular recognition site; other site 640131003155 dimerization interface [polypeptide binding]; other site 640131003156 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 640131003157 putative binding surface; other site 640131003158 active site 640131003159 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 640131003160 TRAM domain; Region: TRAM; pfam01938 640131003161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131003162 S-adenosylmethionine binding site [chemical binding]; other site 640131003163 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 640131003164 HD domain; Region: HD_4; pfam13328 640131003165 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 640131003166 synthetase active site [active] 640131003167 NTP binding site [chemical binding]; other site 640131003168 metal binding site [ion binding]; metal-binding site 640131003169 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 640131003170 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 640131003171 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 640131003172 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 640131003173 homodimer interface [polypeptide binding]; other site 640131003174 metal binding site [ion binding]; metal-binding site 640131003175 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 640131003176 homodimer interface [polypeptide binding]; other site 640131003177 active site 640131003178 putative chemical substrate binding site [chemical binding]; other site 640131003179 metal binding site [ion binding]; metal-binding site 640131003180 CTP synthetase; Validated; Region: pyrG; PRK05380 640131003181 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 640131003182 Catalytic site [active] 640131003183 active site 640131003184 UTP binding site [chemical binding]; other site 640131003185 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 640131003186 active site 640131003187 putative oxyanion hole; other site 640131003188 catalytic triad [active] 640131003189 enolase; Provisional; Region: eno; PRK00077 640131003190 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 640131003191 dimer interface [polypeptide binding]; other site 640131003192 metal binding site [ion binding]; metal-binding site 640131003193 substrate binding pocket [chemical binding]; other site 640131003194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131003195 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 640131003196 NAD(P) binding site [chemical binding]; other site 640131003197 active site 640131003198 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 640131003199 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 640131003200 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 640131003201 active site 640131003202 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 640131003203 Flavodoxin; Region: Flavodoxin_1; pfam00258 640131003204 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 640131003205 FAD binding pocket [chemical binding]; other site 640131003206 FAD binding motif [chemical binding]; other site 640131003207 catalytic residues [active] 640131003208 NAD binding pocket [chemical binding]; other site 640131003209 phosphate binding motif [ion binding]; other site 640131003210 beta-alpha-beta structure motif; other site 640131003211 sulfite reductase subunit beta; Provisional; Region: PRK13504 640131003212 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 640131003213 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 640131003214 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 640131003215 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 640131003216 Active Sites [active] 640131003217 helicase Cas3; Provisional; Region: PRK09694 640131003218 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 640131003219 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 640131003220 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 640131003221 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 640131003222 CT1975-like protein; Region: Cas_CT1975; pfam09344 640131003223 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 640131003224 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 640131003225 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 640131003226 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 640131003227 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 640131003228 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 640131003229 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 640131003230 metal binding site [ion binding]; metal-binding site 640131003231 siroheme synthase; Provisional; Region: cysG; PRK10637 640131003232 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 640131003233 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 640131003234 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 640131003235 active site 640131003236 SAM binding site [chemical binding]; other site 640131003237 homodimer interface [polypeptide binding]; other site 640131003238 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 640131003239 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 640131003240 Active Sites [active] 640131003241 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 640131003242 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 640131003243 CysD dimerization site [polypeptide binding]; other site 640131003244 G1 box; other site 640131003245 putative GEF interaction site [polypeptide binding]; other site 640131003246 GTP/Mg2+ binding site [chemical binding]; other site 640131003247 Switch I region; other site 640131003248 G2 box; other site 640131003249 G3 box; other site 640131003250 Switch II region; other site 640131003251 G4 box; other site 640131003252 G5 box; other site 640131003253 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 640131003254 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 640131003255 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 640131003256 ligand-binding site [chemical binding]; other site 640131003257 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 640131003258 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 640131003259 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 640131003260 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 640131003261 substrate binding site; other site 640131003262 dimer interface; other site 640131003263 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 640131003264 homotrimer interaction site [polypeptide binding]; other site 640131003265 zinc binding site [ion binding]; other site 640131003266 CDP-binding sites; other site 640131003267 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 640131003268 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 640131003269 Permutation of conserved domain; other site 640131003270 active site 640131003271 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 640131003272 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 640131003273 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 640131003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131003275 S-adenosylmethionine binding site [chemical binding]; other site 640131003276 lipoprotein NlpD; Provisional; Region: nlpD; PRK10871 640131003277 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131003278 Peptidase family M23; Region: Peptidase_M23; pfam01551 640131003279 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 640131003280 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 640131003281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 640131003282 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 640131003283 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 640131003284 DNA binding residues [nucleotide binding] 640131003285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 640131003286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131003287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003288 putative substrate translocation pore; other site 640131003289 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131003290 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003291 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131003292 putative effector binding pocket; other site 640131003293 dimerization interface [polypeptide binding]; other site 640131003294 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131003295 MarR family; Region: MarR_2; cl17246 640131003296 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 640131003297 Flavoprotein; Region: Flavoprotein; pfam02441 640131003298 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 640131003299 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 640131003300 Hok/gef family; Region: HOK_GEF; pfam01848 640131003301 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 640131003302 MutS domain I; Region: MutS_I; pfam01624 640131003303 MutS domain II; Region: MutS_II; pfam05188 640131003304 MutS domain III; Region: MutS_III; pfam05192 640131003305 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 640131003306 Walker A/P-loop; other site 640131003307 ATP binding site [chemical binding]; other site 640131003308 Q-loop/lid; other site 640131003309 ABC transporter signature motif; other site 640131003310 Walker B; other site 640131003311 D-loop; other site 640131003312 H-loop/switch region; other site 640131003313 Protein of unknown function (DUF1493); Region: DUF1493; pfam07377 640131003314 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 640131003315 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 640131003316 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131003317 Walker A/P-loop; other site 640131003318 ATP binding site [chemical binding]; other site 640131003319 Q-loop/lid; other site 640131003320 ABC transporter signature motif; other site 640131003321 Walker B; other site 640131003322 D-loop; other site 640131003323 H-loop/switch region; other site 640131003324 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131003325 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131003326 ABC-ATPase subunit interface; other site 640131003327 dimer interface [polypeptide binding]; other site 640131003328 putative PBP binding regions; other site 640131003329 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 640131003330 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 640131003331 putative hemin binding site; other site 640131003332 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 640131003333 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 640131003334 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 640131003335 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 640131003336 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131003337 N-terminal plug; other site 640131003338 ligand-binding site [chemical binding]; other site 640131003339 Rdx family; Region: Rdx; cl01407 640131003340 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 640131003341 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131003342 PYR/PP interface [polypeptide binding]; other site 640131003343 dimer interface [polypeptide binding]; other site 640131003344 TPP binding site [chemical binding]; other site 640131003345 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131003346 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 640131003347 TPP-binding site [chemical binding]; other site 640131003348 Membrane transport protein; Region: Mem_trans; cl09117 640131003349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131003350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131003352 dimerization interface [polypeptide binding]; other site 640131003353 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 640131003354 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 640131003355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131003356 ABC-ATPase subunit interface; other site 640131003357 dimer interface [polypeptide binding]; other site 640131003358 putative PBP binding regions; other site 640131003359 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 640131003360 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131003361 ABC-ATPase subunit interface; other site 640131003362 dimer interface [polypeptide binding]; other site 640131003363 putative PBP binding regions; other site 640131003364 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 640131003365 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 640131003366 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 640131003367 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 640131003368 metal binding site [ion binding]; metal-binding site 640131003369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131003370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131003371 DNA binding site [nucleotide binding] 640131003372 domain linker motif; other site 640131003373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 640131003374 ligand binding site [chemical binding]; other site 640131003375 dimerization interface [polypeptide binding]; other site 640131003376 fructokinase; Reviewed; Region: PRK09557 640131003377 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131003378 nucleotide binding site [chemical binding]; other site 640131003379 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 640131003380 methionine cluster; other site 640131003381 active site 640131003382 phosphorylation site [posttranslational modification] 640131003383 metal binding site [ion binding]; metal-binding site 640131003384 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 640131003385 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 640131003386 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 640131003387 active site 640131003388 P-loop; other site 640131003389 phosphorylation site [posttranslational modification] 640131003390 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 640131003391 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 640131003392 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 640131003393 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 640131003394 Interdomain contacts; other site 640131003395 Cytokine receptor motif; other site 640131003396 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 640131003397 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 640131003398 beta-galactosidase; Region: BGL; TIGR03356 640131003399 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 640131003400 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 640131003401 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 640131003402 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003403 Walker A motif; other site 640131003404 ATP binding site [chemical binding]; other site 640131003405 Walker B motif; other site 640131003406 arginine finger; other site 640131003407 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 640131003408 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 640131003409 dimerization interface [polypeptide binding]; other site 640131003410 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 640131003411 ATP binding site [chemical binding]; other site 640131003412 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 640131003413 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 640131003414 hydrogenase assembly chaperone; Provisional; Region: PRK10409 640131003415 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 640131003416 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 640131003417 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 640131003418 Transcriptional repressor of hyc and hyp operons; Region: HycA_repressor; pfam11046 640131003419 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 640131003420 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 640131003421 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 640131003422 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 640131003423 NADH dehydrogenase; Region: NADHdh; cl00469 640131003424 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 640131003425 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 640131003426 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 640131003427 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 640131003428 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131003429 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 640131003430 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 640131003431 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 640131003432 nickel binding site [ion binding]; other site 640131003433 Toxin SymE, type I toxin-antitoxin system; Region: SymE_toxin; pfam08845 640131003434 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 640131003435 beta-galactosidase; Region: BGL; TIGR03356 640131003436 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 640131003437 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131003438 active site turn [active] 640131003439 phosphorylation site [posttranslational modification] 640131003440 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 640131003441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131003442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131003443 DNA binding site [nucleotide binding] 640131003444 domain linker motif; other site 640131003445 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 640131003446 dimerization interface (closed form) [polypeptide binding]; other site 640131003447 ligand binding site [chemical binding]; other site 640131003448 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 640131003449 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 640131003450 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 640131003451 Acylphosphatase; Region: Acylphosphatase; pfam00708 640131003452 HypF finger; Region: zf-HYPF; pfam07503 640131003453 HypF finger; Region: zf-HYPF; pfam07503 640131003454 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 640131003455 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 640131003456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003457 putative substrate translocation pore; other site 640131003458 Transcriptional regulator [Transcription]; Region: IclR; COG1414 640131003459 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131003460 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131003461 hypothetical protein; Validated; Region: PRK06201 640131003462 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 640131003463 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 640131003464 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 640131003465 ligand binding site [chemical binding]; other site 640131003466 NAD binding site [chemical binding]; other site 640131003467 dimerization interface [polypeptide binding]; other site 640131003468 catalytic site [active] 640131003469 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 640131003470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131003471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131003472 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 640131003473 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 640131003474 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 640131003475 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 640131003476 iron binding site [ion binding]; other site 640131003477 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 640131003478 GAF domain; Region: GAF; pfam01590 640131003479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003480 Walker A motif; other site 640131003481 ATP binding site [chemical binding]; other site 640131003482 Walker B motif; other site 640131003483 arginine finger; other site 640131003484 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 640131003485 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 640131003486 putative active site [active] 640131003487 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 640131003488 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 640131003489 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 640131003490 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131003491 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 640131003492 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 640131003493 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 640131003494 putative NAD(P) binding site [chemical binding]; other site 640131003495 active site 640131003496 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 640131003497 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 640131003498 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 640131003499 Nucleoside recognition; Region: Gate; pfam07670 640131003500 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 640131003501 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 640131003502 Transglycosylase SLT domain; Region: SLT_2; pfam13406 640131003503 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131003504 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131003505 catalytic residue [active] 640131003506 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 640131003507 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 640131003508 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 640131003509 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131003510 ABC-ATPase subunit interface; other site 640131003511 dimer interface [polypeptide binding]; other site 640131003512 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 640131003513 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 640131003514 metal binding site [ion binding]; metal-binding site 640131003515 hypothetical protein; Validated; Region: PRK03661 640131003516 recombinase A; Provisional; Region: recA; PRK09354 640131003517 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 640131003518 hexamer interface [polypeptide binding]; other site 640131003519 Walker A motif; other site 640131003520 ATP binding site [chemical binding]; other site 640131003521 Walker B motif; other site 640131003522 recombination regulator RecX; Reviewed; Region: recX; PRK00117 640131003523 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 640131003524 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 640131003525 motif 1; other site 640131003526 active site 640131003527 motif 2; other site 640131003528 motif 3; other site 640131003529 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 640131003530 DHHA1 domain; Region: DHHA1; pfam02272 640131003531 carbon storage regulator; Provisional; Region: PRK01712 640131003532 BON domain; Region: BON; pfam04972 640131003533 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 640131003534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131003535 motif II; other site 640131003536 Predicted membrane protein [Function unknown]; Region: COG1238 640131003537 glutamate--cysteine ligase; Provisional; Region: PRK02107 640131003538 S-ribosylhomocysteinase; Provisional; Region: PRK02260 640131003539 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131003540 Helix-turn-helix domain; Region: HTH_18; pfam12833 640131003541 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131003542 2-isopropylmalate synthase; Validated; Region: PRK03739 640131003543 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 640131003544 active site 640131003545 catalytic residues [active] 640131003546 metal binding site [ion binding]; metal-binding site 640131003547 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 640131003548 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 640131003549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003550 putative substrate translocation pore; other site 640131003551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003552 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 640131003553 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131003554 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131003555 transcriptional repressor MprA; Provisional; Region: PRK10870 640131003556 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131003557 putative L-valine exporter; Provisional; Region: PRK10408 640131003558 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 640131003559 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 640131003560 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 640131003561 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 640131003562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131003563 dimer interface [polypeptide binding]; other site 640131003564 conserved gate region; other site 640131003565 putative PBP binding loops; other site 640131003566 ABC-ATPase subunit interface; other site 640131003567 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 640131003568 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 640131003569 Walker A/P-loop; other site 640131003570 ATP binding site [chemical binding]; other site 640131003571 Q-loop/lid; other site 640131003572 ABC transporter signature motif; other site 640131003573 Walker B; other site 640131003574 D-loop; other site 640131003575 H-loop/switch region; other site 640131003576 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 640131003577 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 640131003578 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 640131003579 dimer interface [polypeptide binding]; other site 640131003580 putative radical transfer pathway; other site 640131003581 diiron center [ion binding]; other site 640131003582 tyrosyl radical; other site 640131003583 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 640131003584 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 640131003585 Class I ribonucleotide reductase; Region: RNR_I; cd01679 640131003586 active site 640131003587 dimer interface [polypeptide binding]; other site 640131003588 catalytic residues [active] 640131003589 effector binding site; other site 640131003590 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 640131003591 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 640131003592 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 640131003593 catalytic residues [active] 640131003594 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 640131003595 Uncharacterized conserved protein [Function unknown]; Region: COG2128 640131003596 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131003597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131003598 DNA-binding site [nucleotide binding]; DNA binding site 640131003599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131003600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131003601 homodimer interface [polypeptide binding]; other site 640131003602 catalytic residue [active] 640131003603 hypothetical protein; Provisional; Region: PRK10132 640131003604 hypothetical protein; Provisional; Region: PRK10556 640131003605 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 640131003606 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 640131003607 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 640131003608 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases [Posttranslational modification, protein turnover, chaperones]; Region: COG3555 640131003609 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 640131003610 active site residue [active] 640131003611 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 640131003612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131003613 dimerization interface [polypeptide binding]; other site 640131003614 putative DNA binding site [nucleotide binding]; other site 640131003615 Transcriptional regulators [Transcription]; Region: MarR; COG1846 640131003616 putative Zn2+ binding site [ion binding]; other site 640131003617 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 640131003618 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131003619 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003620 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 640131003621 putative effector binding pocket; other site 640131003622 putative dimerization interface [polypeptide binding]; other site 640131003623 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 640131003624 active site 640131003625 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 640131003626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003627 Walker A motif; other site 640131003628 ATP binding site [chemical binding]; other site 640131003629 Walker B motif; other site 640131003630 arginine finger; other site 640131003631 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131003632 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 640131003633 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 640131003634 NAD(P) binding site [chemical binding]; other site 640131003635 catalytic residues [active] 640131003636 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131003637 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131003638 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131003639 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131003640 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131003641 PapC N-terminal domain; Region: PapC_N; pfam13954 640131003642 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131003643 PapC C-terminal domain; Region: PapC_C; pfam13953 640131003644 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131003645 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131003646 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131003647 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131003648 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131003649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131003650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131003651 substrate binding pocket [chemical binding]; other site 640131003652 membrane-bound complex binding site; other site 640131003653 hinge residues; other site 640131003654 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 640131003655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131003656 NAD(P) binding site [chemical binding]; other site 640131003657 active site 640131003658 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 640131003659 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 640131003660 putative ligand binding site [chemical binding]; other site 640131003661 NAD binding site [chemical binding]; other site 640131003662 dimerization interface [polypeptide binding]; other site 640131003663 catalytic site [active] 640131003664 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 640131003665 intersubunit interface [polypeptide binding]; other site 640131003666 active site 640131003667 Zn2+ binding site [ion binding]; other site 640131003668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131003669 dimer interface [polypeptide binding]; other site 640131003670 conserved gate region; other site 640131003671 ABC-ATPase subunit interface; other site 640131003672 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131003673 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131003674 Walker A/P-loop; other site 640131003675 ATP binding site [chemical binding]; other site 640131003676 Q-loop/lid; other site 640131003677 ABC transporter signature motif; other site 640131003678 Walker B; other site 640131003679 D-loop; other site 640131003680 H-loop/switch region; other site 640131003681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131003682 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131003683 substrate binding pocket [chemical binding]; other site 640131003684 membrane-bound complex binding site; other site 640131003685 hinge residues; other site 640131003686 oxidase reductase; Provisional; Region: PTZ00273 640131003687 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 640131003688 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 640131003689 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 640131003690 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 640131003691 agmatinase; Region: agmatinase; TIGR01230 640131003692 oligomer interface [polypeptide binding]; other site 640131003693 putative active site [active] 640131003694 Mn binding site [ion binding]; other site 640131003695 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131003696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131003698 dimerization interface [polypeptide binding]; other site 640131003699 hypothetical protein; Provisional; Region: PRK06847 640131003700 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 640131003701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131003702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003703 The C-terminal substsrate binding domain of NodD family of LysR-type transcriptional regulators that regulates the expression of nodulation (nod) genes; contains the type 2 periplasmic binding fold; Region: PBP2_NodD; cd08462 640131003704 putative substrate binding pocket [chemical binding]; other site 640131003705 putative dimerization interface [polypeptide binding]; other site 640131003706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 640131003707 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 640131003708 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 640131003709 putative active site [active] 640131003710 putative metal binding site [ion binding]; other site 640131003711 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 640131003712 iron-sulfur cluster [ion binding]; other site 640131003713 [2Fe-2S] cluster binding site [ion binding]; other site 640131003714 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 640131003715 Putative cyclase; Region: Cyclase; pfam04199 640131003716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003717 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131003718 putative substrate translocation pore; other site 640131003719 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 640131003720 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 640131003721 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 640131003722 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 640131003723 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 640131003724 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 640131003725 Predicted flavoprotein [General function prediction only]; Region: COG0431 640131003726 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 640131003727 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 640131003728 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 640131003729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131003730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131003731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003732 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131003733 putative substrate translocation pore; other site 640131003734 pyranose oxidase; Region: pyranose_ox; TIGR02462 640131003735 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 640131003736 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 640131003737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003738 putative substrate translocation pore; other site 640131003739 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 640131003740 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 640131003741 Predicted transcriptional regulator [Transcription]; Region: COG1959 640131003742 Transcriptional regulator; Region: Rrf2; pfam02082 640131003743 Transcriptional regulator; Region: Rrf2; cl17282 640131003744 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 640131003745 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 640131003746 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131003747 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131003748 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 640131003749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131003750 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 640131003751 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131003752 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131003753 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131003754 putative effector binding pocket; other site 640131003755 putative dimerization interface [polypeptide binding]; other site 640131003756 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 640131003757 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 640131003758 SmpB-tmRNA interface; other site 640131003759 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 640131003760 putative coenzyme Q binding site [chemical binding]; other site 640131003761 hypothetical protein; Validated; Region: PRK01777 640131003762 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 640131003763 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 640131003764 recombination and repair protein; Provisional; Region: PRK10869 640131003765 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 640131003766 Walker A/P-loop; other site 640131003767 ATP binding site [chemical binding]; other site 640131003768 Q-loop/lid; other site 640131003769 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 640131003770 ABC transporter signature motif; other site 640131003771 Walker B; other site 640131003772 D-loop; other site 640131003773 H-loop/switch region; other site 640131003774 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 640131003775 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 640131003776 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 640131003777 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 640131003778 dimer interface [polypeptide binding]; other site 640131003779 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 640131003780 hypothetical protein; Provisional; Region: PRK11573 640131003781 Domain of unknown function DUF21; Region: DUF21; pfam01595 640131003782 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 640131003783 Transporter associated domain; Region: CorC_HlyC; smart01091 640131003784 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 640131003785 signal recognition particle protein; Provisional; Region: PRK10867 640131003786 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 640131003787 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 640131003788 P loop; other site 640131003789 GTP binding site [chemical binding]; other site 640131003790 Signal peptide binding domain; Region: SRP_SPB; pfam02978 640131003791 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 640131003792 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 640131003793 RimM N-terminal domain; Region: RimM; pfam01782 640131003794 PRC-barrel domain; Region: PRC; pfam05239 640131003795 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 640131003796 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 640131003797 Protein of unknown function (DUF2946); Region: DUF2946; pfam11162 640131003798 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 640131003799 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 640131003800 putative outer membrane lipoprotein; Provisional; Region: PRK09967 640131003801 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 640131003802 ligand binding site [chemical binding]; other site 640131003803 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 640131003804 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131003805 metal binding site [ion binding]; metal-binding site 640131003806 active site 640131003807 I-site; other site 640131003808 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 640131003809 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 640131003810 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 640131003811 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 640131003812 Chorismate mutase type II; Region: CM_2; cl00693 640131003813 prephenate dehydrogenase; Validated; Region: PRK08507 640131003814 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 640131003815 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 640131003816 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 640131003817 Prephenate dehydratase; Region: PDT; pfam00800 640131003818 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 640131003819 putative L-Phe binding site [chemical binding]; other site 640131003820 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 640131003821 30S subunit binding site; other site 640131003822 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 640131003823 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 640131003824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131003825 RNA binding surface [nucleotide binding]; other site 640131003826 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 640131003827 active site 640131003828 hypothetical protein; Provisional; Region: PRK10723 640131003829 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 640131003830 protein disaggregation chaperone; Provisional; Region: PRK10865 640131003831 Clp amino terminal domain; Region: Clp_N; pfam02861 640131003832 Clp amino terminal domain; Region: Clp_N; pfam02861 640131003833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003834 Walker A motif; other site 640131003835 ATP binding site [chemical binding]; other site 640131003836 Walker B motif; other site 640131003837 arginine finger; other site 640131003838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003839 Walker A motif; other site 640131003840 ATP binding site [chemical binding]; other site 640131003841 Walker B motif; other site 640131003842 arginine finger; other site 640131003843 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 640131003844 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 640131003845 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131003846 putative substrate translocation pore; other site 640131003847 lipoprotein; Provisional; Region: PRK10759 640131003848 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 640131003849 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 640131003850 domain interface [polypeptide binding]; other site 640131003851 putative active site [active] 640131003852 catalytic site [active] 640131003853 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 640131003854 domain interface [polypeptide binding]; other site 640131003855 putative active site [active] 640131003856 catalytic site [active] 640131003857 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 640131003858 CoA binding domain; Region: CoA_binding_2; pfam13380 640131003859 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 640131003860 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 640131003861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 640131003862 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131003863 Uncharacterized conserved protein [Function unknown]; Region: COG3148 640131003864 thioredoxin 2; Provisional; Region: PRK10996 640131003865 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 640131003866 catalytic residues [active] 640131003867 putative methyltransferase; Provisional; Region: PRK10864 640131003868 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 640131003869 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 640131003870 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 640131003871 ligand binding site [chemical binding]; other site 640131003872 active site 640131003873 UGI interface [polypeptide binding]; other site 640131003874 catalytic site [active] 640131003875 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 640131003876 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 640131003877 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 640131003878 ATP binding site [chemical binding]; other site 640131003879 Mg++ binding site [ion binding]; other site 640131003880 motif III; other site 640131003881 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131003882 nucleotide binding region [chemical binding]; other site 640131003883 ATP-binding site [chemical binding]; other site 640131003884 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 640131003885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 640131003886 L-aspartate oxidase; Provisional; Region: PRK09077 640131003887 L-aspartate oxidase; Provisional; Region: PRK06175 640131003888 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 640131003889 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 640131003890 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 640131003891 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 640131003892 DNA binding residues [nucleotide binding] 640131003893 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 640131003894 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 640131003895 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 640131003896 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 640131003897 anti-sigma E factor; Provisional; Region: rseB; PRK09455 640131003898 SoxR reducing system protein RseC; Provisional; Region: PRK10862 640131003899 GTP-binding protein LepA; Provisional; Region: PRK05433 640131003900 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 640131003901 G1 box; other site 640131003902 putative GEF interaction site [polypeptide binding]; other site 640131003903 GTP/Mg2+ binding site [chemical binding]; other site 640131003904 Switch I region; other site 640131003905 G2 box; other site 640131003906 G3 box; other site 640131003907 Switch II region; other site 640131003908 G4 box; other site 640131003909 G5 box; other site 640131003910 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 640131003911 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 640131003912 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 640131003913 signal peptidase I; Provisional; Region: PRK10861 640131003914 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 640131003915 Catalytic site [active] 640131003916 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 640131003917 ribonuclease III; Reviewed; Region: rnc; PRK00102 640131003918 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 640131003919 dimerization interface [polypeptide binding]; other site 640131003920 active site 640131003921 metal binding site [ion binding]; metal-binding site 640131003922 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 640131003923 dsRNA binding site [nucleotide binding]; other site 640131003924 GTPase Era; Reviewed; Region: era; PRK00089 640131003925 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 640131003926 G1 box; other site 640131003927 GTP/Mg2+ binding site [chemical binding]; other site 640131003928 Switch I region; other site 640131003929 G2 box; other site 640131003930 Switch II region; other site 640131003931 G3 box; other site 640131003932 G4 box; other site 640131003933 G5 box; other site 640131003934 KH domain; Region: KH_2; pfam07650 640131003935 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 640131003936 Recombination protein O N terminal; Region: RecO_N; pfam11967 640131003937 Recombination protein O C terminal; Region: RecO_C; pfam02565 640131003938 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 640131003939 active site 640131003940 hydrophilic channel; other site 640131003941 dimerization interface [polypeptide binding]; other site 640131003942 catalytic residues [active] 640131003943 active site lid [active] 640131003944 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 640131003945 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 640131003946 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131003947 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 640131003948 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 640131003949 putative active site [active] 640131003950 hypothetical protein; Provisional; Region: PRK11590 640131003951 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 640131003952 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 640131003953 nucleoside/Zn binding site; other site 640131003954 dimer interface [polypeptide binding]; other site 640131003955 catalytic motif [active] 640131003956 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 640131003957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131003958 substrate binding pocket [chemical binding]; other site 640131003959 membrane-bound complex binding site; other site 640131003960 hinge residues; other site 640131003961 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131003962 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131003963 catalytic residue [active] 640131003964 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 640131003965 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 640131003966 dimerization interface [polypeptide binding]; other site 640131003967 ATP binding site [chemical binding]; other site 640131003968 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 640131003969 dimerization interface [polypeptide binding]; other site 640131003970 ATP binding site [chemical binding]; other site 640131003971 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 640131003972 putative active site [active] 640131003973 catalytic triad [active] 640131003974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 640131003975 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131003976 dimer interface [polypeptide binding]; other site 640131003977 phosphorylation site [posttranslational modification] 640131003978 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131003979 ATP binding site [chemical binding]; other site 640131003980 Mg2+ binding site [ion binding]; other site 640131003981 G-X-G motif; other site 640131003982 hypothetical protein; Provisional; Region: PRK10722 640131003983 response regulator GlrR; Provisional; Region: PRK15115 640131003984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131003985 active site 640131003986 phosphorylation site [posttranslational modification] 640131003987 intermolecular recognition site; other site 640131003988 dimerization interface [polypeptide binding]; other site 640131003989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131003990 Walker A motif; other site 640131003991 ATP binding site [chemical binding]; other site 640131003992 Walker B motif; other site 640131003993 arginine finger; other site 640131003994 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 640131003995 Nitrogen regulatory protein P-II; Region: P-II; smart00938 640131003996 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 640131003997 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 640131003998 heme-binding site [chemical binding]; other site 640131003999 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 640131004000 FAD binding pocket [chemical binding]; other site 640131004001 FAD binding motif [chemical binding]; other site 640131004002 phosphate binding motif [ion binding]; other site 640131004003 beta-alpha-beta structure motif; other site 640131004004 NAD binding pocket [chemical binding]; other site 640131004005 Heme binding pocket [chemical binding]; other site 640131004006 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 640131004007 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 640131004008 dimer interface [polypeptide binding]; other site 640131004009 active site 640131004010 glycine-pyridoxal phosphate binding site [chemical binding]; other site 640131004011 folate binding site [chemical binding]; other site 640131004012 Predicted membrane protein [Function unknown]; Region: COG2259 640131004013 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 640131004014 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131004015 putative substrate translocation pore; other site 640131004016 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 640131004017 PRD domain; Region: PRD; pfam00874 640131004018 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG3683 640131004019 High-affinity nickel-transport protein; Region: NicO; cl00964 640131004020 High-affinity nickel-transport protein; Region: NicO; cl00964 640131004021 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 640131004022 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 640131004023 active site 640131004024 dimerization interface [polypeptide binding]; other site 640131004025 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 640131004026 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 640131004027 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 640131004028 Rrf2 family protein; Region: rrf2_super; TIGR00738 640131004029 cysteine desulfurase; Provisional; Region: PRK14012 640131004030 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 640131004031 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131004032 catalytic residue [active] 640131004033 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 640131004034 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 640131004035 trimerization site [polypeptide binding]; other site 640131004036 active site 640131004037 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 640131004038 co-chaperone HscB; Provisional; Region: hscB; PRK05014 640131004039 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 640131004040 HSP70 interaction site [polypeptide binding]; other site 640131004041 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 640131004042 chaperone protein HscA; Provisional; Region: hscA; PRK05183 640131004043 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 640131004044 nucleotide binding site [chemical binding]; other site 640131004045 putative NEF/HSP70 interaction site [polypeptide binding]; other site 640131004046 SBD interface [polypeptide binding]; other site 640131004047 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 640131004048 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131004049 catalytic loop [active] 640131004050 iron binding site [ion binding]; other site 640131004051 hypothetical protein; Provisional; Region: PRK10721 640131004052 aminopeptidase B; Provisional; Region: PRK05015 640131004053 Peptidase; Region: DUF3663; pfam12404 640131004054 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 640131004055 interface (dimer of trimers) [polypeptide binding]; other site 640131004056 Substrate-binding/catalytic site; other site 640131004057 Zn-binding sites [ion binding]; other site 640131004058 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 640131004059 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 640131004060 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 640131004061 active site residue [active] 640131004062 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 640131004063 active site residue [active] 640131004064 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 640131004065 MG2 domain; Region: A2M_N; pfam01835 640131004066 Alpha-2-macroglobulin family; Region: A2M; pfam00207 640131004067 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 640131004068 surface patch; other site 640131004069 thioester region; other site 640131004070 specificity defining residues; other site 640131004071 penicillin-binding protein 1C; Provisional; Region: PRK11240 640131004072 Transglycosylase; Region: Transgly; pfam00912 640131004073 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 640131004074 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 640131004075 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 640131004076 active site 640131004077 multimer interface [polypeptide binding]; other site 640131004078 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 640131004079 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131004080 FeS/SAM binding site; other site 640131004081 cytoskeletal protein RodZ; Provisional; Region: PRK10856 640131004082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131004083 non-specific DNA binding site [nucleotide binding]; other site 640131004084 salt bridge; other site 640131004085 sequence-specific DNA binding site [nucleotide binding]; other site 640131004086 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 640131004087 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 640131004088 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 640131004089 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 640131004090 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 640131004091 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 640131004092 dimer interface [polypeptide binding]; other site 640131004093 motif 1; other site 640131004094 active site 640131004095 motif 2; other site 640131004096 motif 3; other site 640131004097 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 640131004098 anticodon binding site; other site 640131004099 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 640131004100 Uncharacterized protein conserved in bacteria (DUF2133); Region: DUF2133; pfam09976 640131004101 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 640131004102 Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276 640131004103 Trp docking motif [polypeptide binding]; other site 640131004104 GTP-binding protein Der; Reviewed; Region: PRK00093 640131004105 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 640131004106 G1 box; other site 640131004107 GTP/Mg2+ binding site [chemical binding]; other site 640131004108 Switch I region; other site 640131004109 G2 box; other site 640131004110 Switch II region; other site 640131004111 G3 box; other site 640131004112 G4 box; other site 640131004113 G5 box; other site 640131004114 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 640131004115 G1 box; other site 640131004116 GTP/Mg2+ binding site [chemical binding]; other site 640131004117 Switch I region; other site 640131004118 G2 box; other site 640131004119 G3 box; other site 640131004120 Switch II region; other site 640131004121 G4 box; other site 640131004122 G5 box; other site 640131004123 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131004124 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131004125 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 640131004126 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 640131004127 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 640131004128 generic binding surface II; other site 640131004129 generic binding surface I; other site 640131004130 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 640131004131 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 640131004132 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 640131004133 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 640131004134 active site 640131004135 GMP synthase; Reviewed; Region: guaA; PRK00074 640131004136 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 640131004137 AMP/PPi binding site [chemical binding]; other site 640131004138 candidate oxyanion hole; other site 640131004139 catalytic triad [active] 640131004140 potential glutamine specificity residues [chemical binding]; other site 640131004141 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 640131004142 ATP Binding subdomain [chemical binding]; other site 640131004143 Ligand Binding sites [chemical binding]; other site 640131004144 Dimerization subdomain; other site 640131004145 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131004146 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131004147 putative substrate translocation pore; other site 640131004148 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131004149 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131004150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131004151 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 640131004152 MASE1; Region: MASE1; cl17823 640131004153 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131004154 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 640131004155 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131004156 exopolyphosphatase; Provisional; Region: PRK10854 640131004157 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 640131004158 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 640131004159 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 640131004160 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 640131004161 Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164 640131004162 domain interface [polypeptide binding]; other site 640131004163 active site 640131004164 catalytic site [active] 640131004165 Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167 640131004166 domain interface [polypeptide binding]; other site 640131004167 active site 640131004168 catalytic site [active] 640131004169 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 640131004170 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 640131004171 active site 640131004172 substrate binding site [chemical binding]; other site 640131004173 cosubstrate binding site; other site 640131004174 catalytic site [active] 640131004175 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 640131004176 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 640131004177 dimerization interface [polypeptide binding]; other site 640131004178 putative ATP binding site [chemical binding]; other site 640131004179 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 640131004180 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131004181 nucleotide binding site [chemical binding]; other site 640131004182 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 640131004183 beta-galactosidase; Region: BGL; TIGR03356 640131004184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131004185 active site 640131004186 uracil transporter; Provisional; Region: PRK10720 640131004187 DNA replication initiation factor; Provisional; Region: PRK08084 640131004188 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 640131004189 hypothetical protein; Provisional; Region: PRK09956 640131004190 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 640131004191 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 640131004192 ArsC family; Region: ArsC; pfam03960 640131004193 catalytic residues [active] 640131004194 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 640131004195 Peptidase family M48; Region: Peptidase_M48; cl12018 640131004196 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 640131004197 Domain of unknown function DUF20; Region: UPF0118; pfam01594 640131004198 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 640131004199 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 640131004200 catalytic triad [active] 640131004201 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 640131004202 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 640131004203 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 640131004204 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 640131004205 dihydrodipicolinate synthase; Region: dapA; TIGR00674 640131004206 dimer interface [polypeptide binding]; other site 640131004207 active site 640131004208 catalytic residue [active] 640131004209 lipoprotein; Provisional; Region: PRK11679 640131004210 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 640131004211 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 640131004212 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 640131004213 ATP binding site [chemical binding]; other site 640131004214 active site 640131004215 substrate binding site [chemical binding]; other site 640131004216 Predicted metalloprotease [General function prediction only]; Region: COG2321 640131004217 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 640131004218 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 640131004219 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 640131004220 Helicase; Region: Helicase_RecD; pfam05127 640131004221 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 640131004222 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 640131004223 putative hydrolase; Provisional; Region: PRK11460 640131004224 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 640131004225 hypothetical protein; Provisional; Region: PRK13664 640131004226 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 640131004227 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 640131004228 metal binding site [ion binding]; metal-binding site 640131004229 dimer interface [polypeptide binding]; other site 640131004230 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 640131004231 ArsC family; Region: ArsC; pfam03960 640131004232 putative catalytic residues [active] 640131004233 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 640131004234 Protein export membrane protein; Region: SecD_SecF; cl14618 640131004235 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 640131004236 4Fe-4S binding domain; Region: Fer4; pfam00037 640131004237 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131004238 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131004239 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 640131004240 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 640131004241 dimer interface [polypeptide binding]; other site 640131004242 ADP-ribose binding site [chemical binding]; other site 640131004243 active site 640131004244 nudix motif; other site 640131004245 metal binding site [ion binding]; metal-binding site 640131004246 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 640131004247 transketolase; Reviewed; Region: PRK12753 640131004248 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 640131004249 TPP-binding site [chemical binding]; other site 640131004250 dimer interface [polypeptide binding]; other site 640131004251 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 640131004252 PYR/PP interface [polypeptide binding]; other site 640131004253 dimer interface [polypeptide binding]; other site 640131004254 TPP binding site [chemical binding]; other site 640131004255 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131004256 transaldolase-like protein; Provisional; Region: PTZ00411 640131004257 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 640131004258 active site 640131004259 dimer interface [polypeptide binding]; other site 640131004260 catalytic residue [active] 640131004261 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 640131004262 Malic enzyme, N-terminal domain; Region: malic; pfam00390 640131004263 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 640131004264 putative NAD(P) binding site [chemical binding]; other site 640131004265 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 640131004266 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 640131004267 putative hexamer interface [polypeptide binding]; other site 640131004268 putative hexagonal pore; other site 640131004269 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 640131004270 G1 box; other site 640131004271 GTP/Mg2+ binding site [chemical binding]; other site 640131004272 G2 box; other site 640131004273 Switch I region; other site 640131004274 G3 box; other site 640131004275 Switch II region; other site 640131004276 G4 box; other site 640131004277 G5 box; other site 640131004278 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 640131004279 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 640131004280 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 640131004281 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 640131004282 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131004283 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 640131004284 Hexamer interface [polypeptide binding]; other site 640131004285 Hexagonal pore residue; other site 640131004286 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 640131004287 Hexamer/Pentamer interface [polypeptide binding]; other site 640131004288 central pore; other site 640131004289 aldehyde dehydrogenase EutE; Provisional; Region: PRK15398 640131004290 NAD(P) binding site [chemical binding]; other site 640131004291 catalytic residues [active] 640131004292 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 640131004293 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131004294 nucleotide binding site [chemical binding]; other site 640131004295 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 640131004296 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 640131004297 active site 640131004298 metal binding site [ion binding]; metal-binding site 640131004299 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 640131004300 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 640131004301 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 640131004302 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 640131004303 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 640131004304 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 640131004305 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 640131004306 putative hexamer interface [polypeptide binding]; other site 640131004307 putative hexagonal pore; other site 640131004308 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 640131004309 putative hexamer interface [polypeptide binding]; other site 640131004310 putative hexagonal pore; other site 640131004311 carboxysome structural protein EutK; Provisional; Region: PRK15466 640131004312 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 640131004313 Hexamer interface [polypeptide binding]; other site 640131004314 Hexagonal pore residue; other site 640131004315 transcriptional regulator EutR; Provisional; Region: PRK10130 640131004316 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131004317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131004318 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 640131004319 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 640131004320 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 640131004321 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 640131004322 active site 640131004323 metal binding site [ion binding]; metal-binding site 640131004324 putative acetyltransferase; Provisional; Region: PRK03624 640131004325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131004326 Coenzyme A binding pocket [chemical binding]; other site 640131004327 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 640131004328 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 640131004329 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 640131004330 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 640131004331 thiosulfate transporter subunit; Provisional; Region: PRK10852 640131004332 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 640131004333 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 640131004334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004335 dimer interface [polypeptide binding]; other site 640131004336 conserved gate region; other site 640131004337 putative PBP binding loops; other site 640131004338 ABC-ATPase subunit interface; other site 640131004339 sulfate transport protein; Provisional; Region: cysT; CHL00187 640131004340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004341 dimer interface [polypeptide binding]; other site 640131004342 conserved gate region; other site 640131004343 putative PBP binding loops; other site 640131004344 ABC-ATPase subunit interface; other site 640131004345 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 640131004346 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 640131004347 Walker A/P-loop; other site 640131004348 ATP binding site [chemical binding]; other site 640131004349 Q-loop/lid; other site 640131004350 ABC transporter signature motif; other site 640131004351 Walker B; other site 640131004352 D-loop; other site 640131004353 H-loop/switch region; other site 640131004354 TOBE-like domain; Region: TOBE_3; pfam12857 640131004355 cysteine synthase B; Region: cysM; TIGR01138 640131004356 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 640131004357 dimer interface [polypeptide binding]; other site 640131004358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131004359 catalytic residue [active] 640131004360 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 640131004361 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 640131004362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131004363 DNA-binding site [nucleotide binding]; DNA binding site 640131004364 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131004365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131004366 homodimer interface [polypeptide binding]; other site 640131004367 catalytic residue [active] 640131004368 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 640131004369 dimer interface [polypeptide binding]; other site 640131004370 pyridoxamine kinase; Validated; Region: PRK05756 640131004371 pyridoxal binding site [chemical binding]; other site 640131004372 ATP binding site [chemical binding]; other site 640131004373 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 640131004374 HPr interaction site; other site 640131004375 glycerol kinase (GK) interaction site [polypeptide binding]; other site 640131004376 active site 640131004377 phosphorylation site [posttranslational modification] 640131004378 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 640131004379 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 640131004380 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 640131004381 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 640131004382 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 640131004383 dimerization domain swap beta strand [polypeptide binding]; other site 640131004384 regulatory protein interface [polypeptide binding]; other site 640131004385 active site 640131004386 regulatory phosphorylation site [posttranslational modification]; other site 640131004387 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 640131004388 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 640131004389 dimer interface [polypeptide binding]; other site 640131004390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131004391 catalytic residue [active] 640131004392 putative sulfate transport protein CysZ; Validated; Region: PRK04949 640131004393 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 640131004394 cell division protein ZipA; Provisional; Region: PRK03427 640131004395 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 640131004396 FtsZ protein binding site [polypeptide binding]; other site 640131004397 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 640131004398 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 640131004399 nucleotide binding pocket [chemical binding]; other site 640131004400 K-X-D-G motif; other site 640131004401 catalytic site [active] 640131004402 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 640131004403 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 640131004404 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 640131004405 Dimer interface [polypeptide binding]; other site 640131004406 Protein of unknown function (DUF3820); Region: DUF3820; pfam12843 640131004407 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 640131004408 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 640131004409 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131004410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131004411 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 640131004412 putative dimerization interface [polypeptide binding]; other site 640131004413 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 640131004414 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 640131004415 active site 640131004416 HIGH motif; other site 640131004417 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 640131004418 active site 640131004419 KMSKS motif; other site 640131004420 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 640131004421 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 640131004422 MASE1; Region: MASE1; pfam05231 640131004423 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131004424 metal binding site [ion binding]; metal-binding site 640131004425 active site 640131004426 I-site; other site 640131004427 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131004428 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 640131004429 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 640131004430 Nucleoside recognition; Region: Gate; pfam07670 640131004431 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 640131004432 manganese transport protein MntH; Reviewed; Region: PRK00701 640131004433 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 640131004434 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 640131004435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131004436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131004437 active site 640131004438 catalytic tetrad [active] 640131004439 indolepyruvate decarboxylase, Erwinia family; Region: indolpyr_decarb; TIGR03393 640131004440 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 640131004441 dimer interface [polypeptide binding]; other site 640131004442 PYR/PP interface [polypeptide binding]; other site 640131004443 TPP binding site [chemical binding]; other site 640131004444 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131004445 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 640131004446 TPP-binding site [chemical binding]; other site 640131004447 dimer interface [polypeptide binding]; other site 640131004448 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 640131004449 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 640131004450 Cl- selectivity filter; other site 640131004451 Cl- binding residues [ion binding]; other site 640131004452 pore gating glutamate residue; other site 640131004453 dimer interface [polypeptide binding]; other site 640131004454 glucokinase; Provisional; Region: glk; PRK00292 640131004455 glucokinase, proteobacterial type; Region: glk; TIGR00749 640131004456 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 640131004457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131004458 active site 640131004459 phosphorylation site [posttranslational modification] 640131004460 intermolecular recognition site; other site 640131004461 dimerization interface [polypeptide binding]; other site 640131004462 LytTr DNA-binding domain; Region: LytTR; pfam04397 640131004463 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 640131004464 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 640131004465 Histidine kinase; Region: His_kinase; pfam06580 640131004466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131004467 ATP binding site [chemical binding]; other site 640131004468 Mg2+ binding site [ion binding]; other site 640131004469 G-X-G motif; other site 640131004470 aminotransferase; Validated; Region: PRK08175 640131004471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131004472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131004473 homodimer interface [polypeptide binding]; other site 640131004474 catalytic residue [active] 640131004475 putative cyanate transporter; Provisional; Region: cynX; PRK09705 640131004476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131004477 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 640131004478 nucleoside/Zn binding site; other site 640131004479 dimer interface [polypeptide binding]; other site 640131004480 catalytic motif [active] 640131004481 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 640131004482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131004483 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 640131004484 dimerization interface [polypeptide binding]; other site 640131004485 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 640131004486 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 640131004487 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 640131004488 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 640131004489 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 640131004490 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 640131004491 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131004492 dimer interface [polypeptide binding]; other site 640131004493 active site 640131004494 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 640131004495 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 640131004496 substrate binding site [chemical binding]; other site 640131004497 oxyanion hole (OAH) forming residues; other site 640131004498 trimer interface [polypeptide binding]; other site 640131004499 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 640131004500 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131004501 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131004502 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 640131004503 catalytic core [active] 640131004504 hypothetical protein; Provisional; Region: PRK04946 640131004505 Smr domain; Region: Smr; pfam01713 640131004506 HemK family putative methylases; Region: hemK_fam; TIGR00536 640131004507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131004508 S-adenosylmethionine binding site [chemical binding]; other site 640131004509 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 640131004510 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 640131004511 Tetramer interface [polypeptide binding]; other site 640131004512 active site 640131004513 FMN-binding site [chemical binding]; other site 640131004514 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 640131004515 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 640131004516 hypothetical protein; Provisional; Region: PRK10621 640131004517 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 640131004518 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 640131004519 YfcL protein; Region: YfcL; pfam08891 640131004520 Uncharacterized conserved protein [Function unknown]; Region: COG4121 640131004521 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 640131004522 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 640131004523 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 640131004524 dimer interface [polypeptide binding]; other site 640131004525 active site 640131004526 putative transporter; Provisional; Region: PRK12382 640131004527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 640131004528 putative substrate translocation pore; other site 640131004529 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 640131004530 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131004531 DNA-binding site [nucleotide binding]; DNA binding site 640131004532 UTRA domain; Region: UTRA; pfam07702 640131004533 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 640131004534 active site 640131004535 P-loop; other site 640131004536 phosphorylation site [posttranslational modification] 640131004537 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 640131004538 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 640131004539 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 640131004540 active site 640131004541 methionine cluster; other site 640131004542 phosphorylation site [posttranslational modification] 640131004543 metal binding site [ion binding]; metal-binding site 640131004544 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 640131004545 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131004546 trimer interface; other site 640131004547 sugar binding site [chemical binding]; other site 640131004548 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 640131004549 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 640131004550 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 640131004551 ligand binding site [chemical binding]; other site 640131004552 NAD binding site [chemical binding]; other site 640131004553 catalytic site [active] 640131004554 homodimer interface [polypeptide binding]; other site 640131004555 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 640131004556 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 640131004557 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 640131004558 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 640131004559 dimerization interface 3.5A [polypeptide binding]; other site 640131004560 active site 640131004561 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 640131004562 hypothetical protein; Provisional; Region: PRK10847 640131004563 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 640131004564 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 640131004565 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 640131004566 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 640131004567 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 640131004568 cell division protein DedD; Provisional; Region: PRK11633 640131004569 Sporulation related domain; Region: SPOR; pfam05036 640131004570 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 640131004571 colicin V production protein; Provisional; Region: PRK10845 640131004572 amidophosphoribosyltransferase; Provisional; Region: PRK09246 640131004573 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 640131004574 active site 640131004575 tetramer interface [polypeptide binding]; other site 640131004576 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131004577 active site 640131004578 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 640131004579 Flavoprotein; Region: Flavoprotein; pfam02441 640131004580 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 640131004581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131004582 substrate binding pocket [chemical binding]; other site 640131004583 membrane-bound complex binding site; other site 640131004584 hinge residues; other site 640131004585 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 640131004586 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131004587 substrate binding pocket [chemical binding]; other site 640131004588 membrane-bound complex binding site; other site 640131004589 hinge residues; other site 640131004590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004592 dimer interface [polypeptide binding]; other site 640131004593 conserved gate region; other site 640131004594 putative PBP binding loops; other site 640131004595 ABC-ATPase subunit interface; other site 640131004596 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131004597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004598 dimer interface [polypeptide binding]; other site 640131004599 conserved gate region; other site 640131004600 putative PBP binding loops; other site 640131004601 ABC-ATPase subunit interface; other site 640131004602 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 640131004603 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131004604 Walker A/P-loop; other site 640131004605 ATP binding site [chemical binding]; other site 640131004606 Q-loop/lid; other site 640131004607 ABC transporter signature motif; other site 640131004608 Walker B; other site 640131004609 D-loop; other site 640131004610 H-loop/switch region; other site 640131004611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 640131004612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131004613 Coenzyme A binding pocket [chemical binding]; other site 640131004614 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 640131004615 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 640131004616 putative NAD(P) binding site [chemical binding]; other site 640131004617 putative active site [active] 640131004618 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 640131004619 homooctamer interface [polypeptide binding]; other site 640131004620 active site 640131004621 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 640131004622 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 640131004623 C-terminal domain interface [polypeptide binding]; other site 640131004624 GSH binding site (G-site) [chemical binding]; other site 640131004625 dimer interface [polypeptide binding]; other site 640131004626 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 640131004627 N-terminal domain interface [polypeptide binding]; other site 640131004628 putative dimer interface [polypeptide binding]; other site 640131004629 active site 640131004630 glutathione S-transferase; Provisional; Region: PRK15113 640131004631 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 640131004632 C-terminal domain interface [polypeptide binding]; other site 640131004633 GSH binding site (G-site) [chemical binding]; other site 640131004634 dimer interface [polypeptide binding]; other site 640131004635 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 640131004636 N-terminal domain interface [polypeptide binding]; other site 640131004637 putative dimer interface [polypeptide binding]; other site 640131004638 putative substrate binding pocket (H-site) [chemical binding]; other site 640131004639 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 640131004640 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 640131004641 active site 640131004642 metal binding site [ion binding]; metal-binding site 640131004643 homotetramer interface [polypeptide binding]; other site 640131004644 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 640131004645 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 640131004646 nudix motif; other site 640131004647 phosphate acetyltransferase; Reviewed; Region: PRK05632 640131004648 DRTGG domain; Region: DRTGG; pfam07085 640131004649 phosphate acetyltransferase; Region: pta; TIGR00651 640131004650 propionate/acetate kinase; Provisional; Region: PRK12379 640131004651 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 640131004652 hypothetical protein; Provisional; Region: PRK01816 640131004653 hypothetical protein; Validated; Region: PRK05445 640131004654 putative phosphatase; Provisional; Region: PRK11587 640131004655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131004656 motif II; other site 640131004657 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 640131004658 transmembrane helices; other site 640131004659 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 640131004660 TrkA-C domain; Region: TrkA_C; pfam02080 640131004661 TrkA-C domain; Region: TrkA_C; pfam02080 640131004662 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 640131004663 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131004664 Zn2+ binding site [ion binding]; other site 640131004665 Mg2+ binding site [ion binding]; other site 640131004666 aminotransferase AlaT; Validated; Region: PRK09265 640131004667 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131004668 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131004669 homodimer interface [polypeptide binding]; other site 640131004670 catalytic residue [active] 640131004671 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 640131004672 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131004673 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 640131004674 putative dimerization interface [polypeptide binding]; other site 640131004675 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 640131004676 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 640131004677 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 640131004678 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 640131004679 NADH dehydrogenase subunit D; Validated; Region: PRK06075 640131004680 NADH dehydrogenase subunit E; Validated; Region: PRK07539 640131004681 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 640131004682 putative dimer interface [polypeptide binding]; other site 640131004683 [2Fe-2S] cluster binding site [ion binding]; other site 640131004684 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 640131004685 SLBB domain; Region: SLBB; pfam10531 640131004686 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 640131004687 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 640131004688 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131004689 catalytic loop [active] 640131004690 iron binding site [ion binding]; other site 640131004691 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 640131004692 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 640131004693 [4Fe-4S] binding site [ion binding]; other site 640131004694 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 640131004695 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 640131004696 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 640131004697 4Fe-4S binding domain; Region: Fer4; pfam00037 640131004698 4Fe-4S binding domain; Region: Fer4; pfam00037 640131004699 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 640131004700 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 640131004701 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 640131004702 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 640131004703 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 640131004704 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 640131004705 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 640131004706 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 640131004707 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 640131004708 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 640131004709 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 640131004710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131004711 Coenzyme A binding pocket [chemical binding]; other site 640131004712 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 640131004713 chorismate binding enzyme; Region: Chorismate_bind; cl10555 640131004714 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 640131004715 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 640131004716 dimer interface [polypeptide binding]; other site 640131004717 tetramer interface [polypeptide binding]; other site 640131004718 PYR/PP interface [polypeptide binding]; other site 640131004719 TPP binding site [chemical binding]; other site 640131004720 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 640131004721 TPP-binding site; other site 640131004722 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 640131004723 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 640131004724 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 640131004725 substrate binding site [chemical binding]; other site 640131004726 oxyanion hole (OAH) forming residues; other site 640131004727 trimer interface [polypeptide binding]; other site 640131004728 O-succinylbenzoate synthase; Provisional; Region: PRK05105 640131004729 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 640131004730 active site 640131004731 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 640131004732 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 640131004733 acyl-activating enzyme (AAE) consensus motif; other site 640131004734 putative AMP binding site [chemical binding]; other site 640131004735 putative active site [active] 640131004736 putative CoA binding site [chemical binding]; other site 640131004737 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 640131004738 putative transposase; Provisional; Region: PRK09857 640131004739 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 640131004740 YfaZ precursor; Region: YfaZ; pfam07437 640131004741 Organic solvent tolerance protein; Region: OstA_C; pfam04453 640131004742 hypothetical protein; Provisional; Region: PRK03673 640131004743 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 640131004744 putative MPT binding site; other site 640131004745 Competence-damaged protein; Region: CinA; cl00666 640131004746 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131004747 Transcriptional regulator [Transcription]; Region: IclR; COG1414 640131004748 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131004749 L-rhamnonate dehydratase; Provisional; Region: PRK15440 640131004750 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 640131004751 putative active site pocket [active] 640131004752 putative metal binding site [ion binding]; other site 640131004753 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 640131004754 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131004755 putative substrate translocation pore; other site 640131004756 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 640131004757 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 640131004758 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131004759 Cysteine-rich domain; Region: CCG; pfam02754 640131004760 Cysteine-rich domain; Region: CCG; pfam02754 640131004761 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 640131004762 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 640131004763 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 640131004764 hydroxyglutarate oxidase; Provisional; Region: PRK11728 640131004765 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 640131004766 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 640131004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131004768 putative substrate translocation pore; other site 640131004769 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 640131004770 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 640131004771 active site 640131004772 catalytic site [active] 640131004773 metal binding site [ion binding]; metal-binding site 640131004774 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 640131004775 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131004776 catalytic loop [active] 640131004777 iron binding site [ion binding]; other site 640131004778 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 640131004779 dimer interface [polypeptide binding]; other site 640131004780 putative radical transfer pathway; other site 640131004781 diiron center [ion binding]; other site 640131004782 tyrosyl radical; other site 640131004783 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 640131004784 ATP cone domain; Region: ATP-cone; pfam03477 640131004785 Class I ribonucleotide reductase; Region: RNR_I; cd01679 640131004786 active site 640131004787 dimer interface [polypeptide binding]; other site 640131004788 catalytic residues [active] 640131004789 effector binding site; other site 640131004790 R2 peptide binding site; other site 640131004791 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 640131004792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131004793 S-adenosylmethionine binding site [chemical binding]; other site 640131004794 DNA gyrase subunit A; Validated; Region: PRK05560 640131004795 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 640131004796 CAP-like domain; other site 640131004797 active site 640131004798 primary dimer interface [polypeptide binding]; other site 640131004799 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 640131004800 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 640131004801 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 640131004802 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 640131004803 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 640131004804 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 640131004805 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 640131004806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131004807 dimer interface [polypeptide binding]; other site 640131004808 phosphorylation site [posttranslational modification] 640131004809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131004810 ATP binding site [chemical binding]; other site 640131004811 Mg2+ binding site [ion binding]; other site 640131004812 G-X-G motif; other site 640131004813 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 640131004814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131004815 active site 640131004816 phosphorylation site [posttranslational modification] 640131004817 intermolecular recognition site; other site 640131004818 dimerization interface [polypeptide binding]; other site 640131004819 transcriptional regulator RcsB; Provisional; Region: PRK10840 640131004820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131004821 active site 640131004822 phosphorylation site [posttranslational modification] 640131004823 intermolecular recognition site; other site 640131004824 dimerization interface [polypeptide binding]; other site 640131004825 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131004826 DNA binding residues [nucleotide binding] 640131004827 dimerization interface [polypeptide binding]; other site 640131004828 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 640131004829 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131004830 ATP binding site [chemical binding]; other site 640131004831 Mg2+ binding site [ion binding]; other site 640131004832 G-X-G motif; other site 640131004833 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 640131004834 putative binding surface; other site 640131004835 active site 640131004836 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 640131004837 outer membrane porin protein C; Provisional; Region: PRK10554 640131004838 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 640131004839 ApbE family; Region: ApbE; pfam02424 640131004840 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 640131004841 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 640131004842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131004843 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 640131004844 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 640131004845 DNA binding site [nucleotide binding] 640131004846 active site 640131004847 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 640131004848 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 640131004849 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 640131004850 Walker A/P-loop; other site 640131004851 ATP binding site [chemical binding]; other site 640131004852 Q-loop/lid; other site 640131004853 ABC transporter signature motif; other site 640131004854 Walker B; other site 640131004855 D-loop; other site 640131004856 H-loop/switch region; other site 640131004857 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 640131004858 MgtE intracellular N domain; Region: MgtE_N; smart00924 640131004859 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 640131004860 Divalent cation transporter; Region: MgtE; cl00786 640131004861 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 640131004862 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 640131004863 Sulfate transporter family; Region: Sulfate_transp; pfam00916 640131004864 malate:quinone oxidoreductase; Validated; Region: PRK05257 640131004865 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 640131004866 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 640131004867 secondary substrate binding site; other site 640131004868 primary substrate binding site; other site 640131004869 inhibition loop; other site 640131004870 dimerization interface [polypeptide binding]; other site 640131004871 Domain of unknown function DUF20; Region: UPF0118; pfam01594 640131004872 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 640131004873 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131004874 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131004875 Walker A/P-loop; other site 640131004876 ATP binding site [chemical binding]; other site 640131004877 Q-loop/lid; other site 640131004878 ABC transporter signature motif; other site 640131004879 Walker B; other site 640131004880 D-loop; other site 640131004881 H-loop/switch region; other site 640131004882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004883 putative PBP binding loops; other site 640131004884 dimer interface [polypeptide binding]; other site 640131004885 ABC-ATPase subunit interface; other site 640131004886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004887 dimer interface [polypeptide binding]; other site 640131004888 conserved gate region; other site 640131004889 putative PBP binding loops; other site 640131004890 ABC-ATPase subunit interface; other site 640131004891 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131004892 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131004893 substrate binding pocket [chemical binding]; other site 640131004894 membrane-bound complex binding site; other site 640131004895 hinge residues; other site 640131004896 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 640131004897 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 640131004898 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 640131004899 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 640131004900 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 640131004901 Sulfatase; Region: Sulfatase; cl17466 640131004902 hypothetical protein; Provisional; Region: PRK13689 640131004903 Nucleoid-associated protein [General function prediction only]; Region: COG3081 640131004904 nucleoid-associated protein NdpA; Validated; Region: PRK00378 640131004905 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131004906 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131004907 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131004908 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 640131004909 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 640131004910 dimer interface [polypeptide binding]; other site 640131004911 ADP-ribose binding site [chemical binding]; other site 640131004912 active site 640131004913 nudix motif; other site 640131004914 metal binding site [ion binding]; metal-binding site 640131004915 Beta-lactamase; Region: Beta-lactamase; pfam00144 640131004916 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 640131004917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131004918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131004919 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131004920 dimerization interface [polypeptide binding]; other site 640131004921 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 640131004922 5S rRNA interface [nucleotide binding]; other site 640131004923 CTC domain interface [polypeptide binding]; other site 640131004924 L16 interface [polypeptide binding]; other site 640131004925 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 640131004926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131004927 ATP binding site [chemical binding]; other site 640131004928 putative Mg++ binding site [ion binding]; other site 640131004929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131004930 nucleotide binding region [chemical binding]; other site 640131004931 ATP-binding site [chemical binding]; other site 640131004932 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 640131004933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131004934 RNA binding surface [nucleotide binding]; other site 640131004935 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 640131004936 active site 640131004937 uracil binding [chemical binding]; other site 640131004938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131004939 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 640131004940 putative substrate translocation pore; other site 640131004941 hypothetical protein; Provisional; Region: PRK11835 640131004942 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 640131004943 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131004944 Walker A/P-loop; other site 640131004945 ATP binding site [chemical binding]; other site 640131004946 Q-loop/lid; other site 640131004947 ABC transporter signature motif; other site 640131004948 Walker B; other site 640131004949 D-loop; other site 640131004950 H-loop/switch region; other site 640131004951 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131004952 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131004953 Walker A/P-loop; other site 640131004954 ATP binding site [chemical binding]; other site 640131004955 Q-loop/lid; other site 640131004956 ABC transporter signature motif; other site 640131004957 Walker B; other site 640131004958 D-loop; other site 640131004959 H-loop/switch region; other site 640131004960 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131004961 microcin C ABC transporter permease; Provisional; Region: PRK15021 640131004962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004963 dimer interface [polypeptide binding]; other site 640131004964 conserved gate region; other site 640131004965 ABC-ATPase subunit interface; other site 640131004966 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 640131004967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131004968 dimer interface [polypeptide binding]; other site 640131004969 conserved gate region; other site 640131004970 putative PBP binding loops; other site 640131004971 ABC-ATPase subunit interface; other site 640131004972 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 640131004973 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 640131004974 phage resistance protein; Provisional; Region: PRK10551 640131004975 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 640131004976 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131004977 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 640131004978 NlpC/P60 family; Region: NLPC_P60; pfam00877 640131004979 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 640131004980 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 640131004981 active site 640131004982 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 640131004983 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 640131004984 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 640131004985 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 640131004986 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 640131004987 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 640131004988 mannonate dehydratase; Provisional; Region: PRK03906 640131004989 mannonate dehydratase; Region: uxuA; TIGR00695 640131004990 elongation factor P; Provisional; Region: PRK04542 640131004991 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 640131004992 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 640131004993 RNA binding site [nucleotide binding]; other site 640131004994 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 640131004995 RNA binding site [nucleotide binding]; other site 640131004996 Flagellin N-methylase; Region: FliB; cl00497 640131004997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131004998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131004999 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131005000 putative effector binding pocket; other site 640131005001 dimerization interface [polypeptide binding]; other site 640131005002 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 640131005003 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 640131005004 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131005005 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 640131005006 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131005007 sugar efflux transporter B; Provisional; Region: PRK15011 640131005008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005009 putative substrate translocation pore; other site 640131005010 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 640131005011 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131005012 active site 640131005013 phosphorylation site [posttranslational modification] 640131005014 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 640131005015 dimerization domain swap beta strand [polypeptide binding]; other site 640131005016 regulatory protein interface [polypeptide binding]; other site 640131005017 active site 640131005018 regulatory phosphorylation site [posttranslational modification]; other site 640131005019 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 640131005020 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 640131005021 putative substrate binding site [chemical binding]; other site 640131005022 putative ATP binding site [chemical binding]; other site 640131005023 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 640131005024 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 640131005025 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 640131005026 active site 640131005027 P-loop; other site 640131005028 phosphorylation site [posttranslational modification] 640131005029 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 640131005030 endonuclease IV; Provisional; Region: PRK01060 640131005031 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 640131005032 DNA interaction; other site 640131005033 Metal-binding active site; metal-binding site 640131005034 AP (apurinic/apyrimidinic) site pocket; other site 640131005035 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 640131005036 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 640131005037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005038 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 640131005039 putative dimerization interface [polypeptide binding]; other site 640131005040 lysine transporter; Provisional; Region: PRK10836 640131005041 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 640131005042 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131005043 N-terminal plug; other site 640131005044 ligand-binding site [chemical binding]; other site 640131005045 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 640131005046 S-formylglutathione hydrolase; Region: PLN02442 640131005047 GTP cyclohydrolase I; Provisional; Region: PLN03044 640131005048 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 640131005049 active site 640131005050 Predicted membrane protein [Function unknown]; Region: COG2311 640131005051 hypothetical protein; Provisional; Region: PRK10835 640131005052 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 640131005053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131005054 DNA binding site [nucleotide binding] 640131005055 domain linker motif; other site 640131005056 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 640131005057 dimerization interface (closed form) [polypeptide binding]; other site 640131005058 ligand binding site [chemical binding]; other site 640131005059 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 640131005060 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 640131005061 ligand binding site [chemical binding]; other site 640131005062 calcium binding site [ion binding]; other site 640131005063 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131005064 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 640131005065 Walker A/P-loop; other site 640131005066 ATP binding site [chemical binding]; other site 640131005067 Q-loop/lid; other site 640131005068 ABC transporter signature motif; other site 640131005069 Walker B; other site 640131005070 D-loop; other site 640131005071 H-loop/switch region; other site 640131005072 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131005073 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131005074 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131005075 TM-ABC transporter signature motif; other site 640131005076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131005077 non-specific DNA binding site [nucleotide binding]; other site 640131005078 salt bridge; other site 640131005079 sequence-specific DNA binding site [nucleotide binding]; other site 640131005080 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 640131005081 putative active site [active] 640131005082 cytidine deaminase; Provisional; Region: PRK09027 640131005083 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 640131005084 active site 640131005085 catalytic motif [active] 640131005086 Zn binding site [ion binding]; other site 640131005087 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 640131005088 active site 640131005089 catalytic motif [active] 640131005090 Zn binding site [ion binding]; other site 640131005091 hypothetical protein; Provisional; Region: PRK10711 640131005092 hypothetical protein; Provisional; Region: PRK01821 640131005093 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 640131005094 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 640131005095 FMN binding site [chemical binding]; other site 640131005096 active site 640131005097 catalytic residues [active] 640131005098 substrate binding site [chemical binding]; other site 640131005099 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 640131005100 transcriptional antiterminator BglG; Provisional; Region: PRK09772 640131005101 CAT RNA binding domain; Region: CAT_RBD; smart01061 640131005102 PRD domain; Region: PRD; pfam00874 640131005103 PRD domain; Region: PRD; pfam00874 640131005104 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 640131005105 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131005106 active site turn [active] 640131005107 phosphorylation site [posttranslational modification] 640131005108 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131005109 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 640131005110 HPr interaction site; other site 640131005111 glycerol kinase (GK) interaction site [polypeptide binding]; other site 640131005112 active site 640131005113 phosphorylation site [posttranslational modification] 640131005114 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 640131005115 beta-galactosidase; Region: BGL; TIGR03356 640131005116 Methyltransferase domain; Region: Methyltransf_31; pfam13847 640131005117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131005118 S-adenosylmethionine binding site [chemical binding]; other site 640131005119 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 640131005120 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 640131005121 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 640131005122 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 640131005123 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 640131005124 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 640131005125 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 640131005126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131005127 Coenzyme A binding pocket [chemical binding]; other site 640131005128 D-lactate dehydrogenase; Provisional; Region: PRK11183 640131005129 FAD binding domain; Region: FAD_binding_4; pfam01565 640131005130 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 640131005131 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 640131005132 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 640131005133 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 640131005134 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 640131005135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131005136 dimer interface [polypeptide binding]; other site 640131005137 conserved gate region; other site 640131005138 ABC-ATPase subunit interface; other site 640131005139 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 640131005140 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 640131005141 Walker A/P-loop; other site 640131005142 ATP binding site [chemical binding]; other site 640131005143 Q-loop/lid; other site 640131005144 ABC transporter signature motif; other site 640131005145 Walker B; other site 640131005146 D-loop; other site 640131005147 H-loop/switch region; other site 640131005148 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 640131005149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131005150 putative PBP binding loops; other site 640131005151 ABC-ATPase subunit interface; other site 640131005152 hypothetical protein; Provisional; Region: PRK13681 640131005153 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 640131005154 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 640131005155 GAF domain; Region: GAF; pfam01590 640131005156 Histidine kinase; Region: His_kinase; pfam06580 640131005157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131005158 ATP binding site [chemical binding]; other site 640131005159 Mg2+ binding site [ion binding]; other site 640131005160 G-X-G motif; other site 640131005161 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 640131005162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131005163 active site 640131005164 phosphorylation site [posttranslational modification] 640131005165 intermolecular recognition site; other site 640131005166 dimerization interface [polypeptide binding]; other site 640131005167 LytTr DNA-binding domain; Region: LytTR; pfam04397 640131005168 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 640131005169 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 640131005170 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 640131005171 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 640131005172 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 640131005173 active site 640131005174 HIGH motif; other site 640131005175 KMSKS motif; other site 640131005176 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 640131005177 tRNA binding surface [nucleotide binding]; other site 640131005178 anticodon binding site; other site 640131005179 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 640131005180 dimer interface [polypeptide binding]; other site 640131005181 putative tRNA-binding site [nucleotide binding]; other site 640131005182 antiporter inner membrane protein; Provisional; Region: PRK11670 640131005183 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 640131005184 Walker A motif; other site 640131005185 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131005186 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131005187 Coenzyme A binding pocket [chemical binding]; other site 640131005188 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 640131005189 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131005190 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005191 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131005192 putative effector binding pocket; other site 640131005193 dimerization interface [polypeptide binding]; other site 640131005194 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 640131005195 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 640131005196 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 640131005197 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 640131005198 active site 640131005199 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 640131005200 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 640131005201 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005202 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131005203 dimerization interface [polypeptide binding]; other site 640131005204 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 640131005205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 640131005206 SCP-2 sterol transfer family; Region: SCP2; pfam02036 640131005207 Transcriptional regulator; Region: Rrf2; cl17282 640131005208 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 640131005209 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 640131005210 SCP-2 sterol transfer family; Region: SCP2; pfam02036 640131005211 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 640131005212 substrate binding site [chemical binding]; other site 640131005213 multimerization interface [polypeptide binding]; other site 640131005214 ATP binding site [chemical binding]; other site 640131005215 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 640131005216 dimer interface [polypeptide binding]; other site 640131005217 substrate binding site [chemical binding]; other site 640131005218 ATP binding site [chemical binding]; other site 640131005219 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 640131005220 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 640131005221 putative active site; other site 640131005222 catalytic residue [active] 640131005223 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 640131005224 Homeodomain-like domain; Region: HTH_23; pfam13384 640131005225 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 640131005226 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 640131005227 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 640131005228 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 640131005229 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 640131005230 N- and C-terminal domain interface [polypeptide binding]; other site 640131005231 D-xylulose kinase; Region: XylB; TIGR01312 640131005232 active site 640131005233 MgATP binding site [chemical binding]; other site 640131005234 catalytic site [active] 640131005235 metal binding site [ion binding]; metal-binding site 640131005236 xylulose binding site [chemical binding]; other site 640131005237 homodimer interface [polypeptide binding]; other site 640131005238 polyol permease family; Region: 2A0118; TIGR00897 640131005239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005240 putative substrate translocation pore; other site 640131005241 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 640131005242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131005243 motif II; other site 640131005244 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 640131005245 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_4; cd03329 640131005246 putative active site pocket [active] 640131005247 metal binding site [ion binding]; metal-binding site 640131005248 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131005249 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 640131005250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131005251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131005252 dimer interface [polypeptide binding]; other site 640131005253 conserved gate region; other site 640131005254 putative PBP binding loops; other site 640131005255 ABC-ATPase subunit interface; other site 640131005256 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 640131005257 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131005258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131005259 dimer interface [polypeptide binding]; other site 640131005260 conserved gate region; other site 640131005261 ABC-ATPase subunit interface; other site 640131005262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 640131005263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131005264 Walker A/P-loop; other site 640131005265 ATP binding site [chemical binding]; other site 640131005266 Q-loop/lid; other site 640131005267 ABC transporter signature motif; other site 640131005268 Walker B; other site 640131005269 D-loop; other site 640131005270 H-loop/switch region; other site 640131005271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131005272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 640131005273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131005274 Walker A/P-loop; other site 640131005275 ATP binding site [chemical binding]; other site 640131005276 Q-loop/lid; other site 640131005277 ABC transporter signature motif; other site 640131005278 Walker B; other site 640131005279 D-loop; other site 640131005280 H-loop/switch region; other site 640131005281 lipid kinase; Reviewed; Region: PRK13054 640131005282 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 640131005283 putative protease; Provisional; Region: PRK15452 640131005284 Peptidase family U32; Region: Peptidase_U32; pfam01136 640131005285 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 640131005286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131005287 active site 640131005288 phosphorylation site [posttranslational modification] 640131005289 intermolecular recognition site; other site 640131005290 dimerization interface [polypeptide binding]; other site 640131005291 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131005292 DNA binding site [nucleotide binding] 640131005293 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 640131005294 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131005295 dimerization interface [polypeptide binding]; other site 640131005296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131005297 dimer interface [polypeptide binding]; other site 640131005298 phosphorylation site [posttranslational modification] 640131005299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131005300 ATP binding site [chemical binding]; other site 640131005301 Mg2+ binding site [ion binding]; other site 640131005302 G-X-G motif; other site 640131005303 putative transporter; Provisional; Region: PRK10504 640131005304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005305 putative substrate translocation pore; other site 640131005306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005307 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 640131005308 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 640131005309 Protein export membrane protein; Region: SecD_SecF; cl14618 640131005310 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 640131005311 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131005312 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131005313 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 640131005314 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 640131005315 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131005316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 640131005317 DNA binding residues [nucleotide binding] 640131005318 transcriptional regulator PhoB; Provisional; Region: PRK10161 640131005319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131005320 active site 640131005321 phosphorylation site [posttranslational modification] 640131005322 intermolecular recognition site; other site 640131005323 dimerization interface [polypeptide binding]; other site 640131005324 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 640131005325 DNA binding site [nucleotide binding] 640131005326 7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696 640131005327 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 640131005328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 640131005329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131005330 dimer interface [polypeptide binding]; other site 640131005331 phosphorylation site [posttranslational modification] 640131005332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131005333 ATP binding site [chemical binding]; other site 640131005334 Mg2+ binding site [ion binding]; other site 640131005335 G-X-G motif; other site 640131005336 putative chaperone; Provisional; Region: PRK11678 640131005337 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 640131005338 nucleotide binding site [chemical binding]; other site 640131005339 putative NEF/HSP70 interaction site [polypeptide binding]; other site 640131005340 SBD interface [polypeptide binding]; other site 640131005341 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 640131005342 AlkA N-terminal domain; Region: AlkA_N; pfam06029 640131005343 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 640131005344 minor groove reading motif; other site 640131005345 helix-hairpin-helix signature motif; other site 640131005346 substrate binding pocket [chemical binding]; other site 640131005347 active site 640131005348 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 640131005349 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 640131005350 ATP-binding site [chemical binding]; other site 640131005351 Sugar specificity; other site 640131005352 Pyrimidine base specificity; other site 640131005353 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 640131005354 trimer interface [polypeptide binding]; other site 640131005355 active site 640131005356 putative assembly protein; Provisional; Region: PRK10833 640131005357 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 640131005358 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 640131005359 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 640131005360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 640131005361 Transporter associated domain; Region: CorC_HlyC; smart01091 640131005362 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 640131005363 active site 640131005364 tetramer interface; other site 640131005365 Acid phosphatase homologues; Region: acidPPc; smart00014 640131005366 active site 640131005367 Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052 640131005368 polysaccharide export protein Wza; Provisional; Region: PRK15078 640131005369 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 640131005370 SLBB domain; Region: SLBB; pfam10531 640131005371 Low molecular weight phosphatase family; Region: LMWPc; cd00115 640131005372 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 640131005373 active site 640131005374 tyrosine kinase; Provisional; Region: PRK11519 640131005375 Chain length determinant protein; Region: Wzz; pfam02706 640131005376 Chain length determinant protein; Region: Wzz; cl15801 640131005377 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 640131005378 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131005379 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 640131005380 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131005381 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 640131005382 putative ADP-binding pocket [chemical binding]; other site 640131005383 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 640131005384 putative ADP-binding pocket [chemical binding]; other site 640131005385 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131005386 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 640131005387 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 640131005388 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 640131005389 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 640131005390 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 640131005391 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 640131005392 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 640131005393 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 640131005394 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 640131005395 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 640131005396 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 640131005397 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 640131005398 putative NAD(P) binding site [chemical binding]; other site 640131005399 active site 640131005400 putative substrate binding site [chemical binding]; other site 640131005401 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 640131005402 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 640131005403 Substrate binding site; other site 640131005404 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 640131005405 phosphomannomutase CpsG; Provisional; Region: PRK15414 640131005406 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 640131005407 active site 640131005408 substrate binding site [chemical binding]; other site 640131005409 metal binding site [ion binding]; metal-binding site 640131005410 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 640131005411 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 640131005412 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 640131005413 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 640131005414 Walker A/P-loop; other site 640131005415 ATP binding site [chemical binding]; other site 640131005416 Q-loop/lid; other site 640131005417 ABC transporter signature motif; other site 640131005418 Walker B; other site 640131005419 D-loop; other site 640131005420 H-loop/switch region; other site 640131005421 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 640131005422 putative carbohydrate binding site [chemical binding]; other site 640131005423 Methyltransferase domain; Region: Methyltransf_31; pfam13847 640131005424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131005425 S-adenosylmethionine binding site [chemical binding]; other site 640131005426 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 640131005427 ATP binding site [chemical binding]; other site 640131005428 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 640131005429 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131005430 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 640131005431 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131005432 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131005433 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 640131005434 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 640131005435 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 640131005436 putative ADP-binding pocket [chemical binding]; other site 640131005437 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 640131005438 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 640131005439 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 640131005440 metal binding site [ion binding]; metal-binding site 640131005441 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 640131005442 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 640131005443 substrate binding site [chemical binding]; other site 640131005444 glutamase interaction surface [polypeptide binding]; other site 640131005445 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 640131005446 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 640131005447 catalytic residues [active] 640131005448 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 640131005449 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 640131005450 putative active site [active] 640131005451 oxyanion strand; other site 640131005452 catalytic triad [active] 640131005453 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 640131005454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131005455 active site 640131005456 motif I; other site 640131005457 motif II; other site 640131005458 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 640131005459 putative active site pocket [active] 640131005460 4-fold oligomerization interface [polypeptide binding]; other site 640131005461 metal binding residues [ion binding]; metal-binding site 640131005462 3-fold/trimer interface [polypeptide binding]; other site 640131005463 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 640131005464 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131005465 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131005466 homodimer interface [polypeptide binding]; other site 640131005467 catalytic residue [active] 640131005468 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 640131005469 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 640131005470 NAD binding site [chemical binding]; other site 640131005471 dimerization interface [polypeptide binding]; other site 640131005472 product binding site; other site 640131005473 substrate binding site [chemical binding]; other site 640131005474 zinc binding site [ion binding]; other site 640131005475 catalytic residues [active] 640131005476 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 640131005477 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 640131005478 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 640131005479 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 640131005480 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 640131005481 putative NAD(P) binding site [chemical binding]; other site 640131005482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005483 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 640131005484 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131005485 dimerization interface [polypeptide binding]; other site 640131005486 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 640131005487 NifQ; Region: NifQ; pfam04891 640131005488 nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290 640131005489 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131005490 FeS/SAM binding site; other site 640131005491 NifB belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme as part of...; Region: NifB; cd00852 640131005492 Nif-specific regulatory protein; Region: nifA; TIGR01817 640131005493 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 640131005494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131005495 Walker A motif; other site 640131005496 ATP binding site [chemical binding]; other site 640131005497 Walker B motif; other site 640131005498 arginine finger; other site 640131005499 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131005500 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 640131005501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131005502 putative active site [active] 640131005503 heme pocket [chemical binding]; other site 640131005504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131005505 ATP binding site [chemical binding]; other site 640131005506 G-X-G motif; other site 640131005507 flavodoxin FldA; Validated; Region: PRK09267 640131005508 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 640131005509 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 640131005510 NifZ domain; Region: NifZ; pfam04319 640131005511 Nitrogen fixation protein NifW; Region: NifW; cl03935 640131005512 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 640131005513 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 640131005514 active site 640131005515 catalytic residues [active] 640131005516 metal binding site [ion binding]; metal-binding site 640131005517 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 640131005518 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 640131005519 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131005520 catalytic residue [active] 640131005521 Fe-S cluster assembly protein NifU; Region: NifU_proper; TIGR02000 640131005522 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 640131005523 trimerization site [polypeptide binding]; other site 640131005524 active site 640131005525 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 640131005526 NifU-like domain; Region: NifU; pfam01106 640131005527 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 640131005528 Nitrogenase_nifN1: A subgroup of the NifN subunit of the NifEN complex: NifN forms an alpha2beta2 tetramer with NifE. NifN and nifE are structurally homologous to nitrogenase MoFe protein beta and alpha subunits respectively. NifEN participates in the...; Region: Nitrogenase_NifN_1; cd01966 640131005529 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 640131005530 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 640131005531 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 640131005532 NifX belongs to a family of iron-molybdenum cluster-binding proteins that includes NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. The protein...; Region: NifX; cd00853 640131005533 NifT/FixU protein; Region: NifT; pfam06988 640131005534 nitrogenase molybdenum-iron protein beta chain; Region: nifK; TIGR01286 640131005535 Domain of unknown function (DUF3364); Region: DUF3364; pfam11844 640131005536 Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974 640131005537 MoFe protein beta/alpha subunit interactions; other site 640131005538 Beta subunit P cluster binding residues; other site 640131005539 MoFe protein beta subunit/Fe protein contacts; other site 640131005540 MoFe protein dimer/ dimer interactions; other site 640131005541 nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283 640131005542 Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976 640131005543 MoFe protein alpha/beta subunit interactions; other site 640131005544 Alpha subunit P cluster binding residues; other site 640131005545 FeMoco binding residues [chemical binding]; other site 640131005546 MoFe protein alpha subunit/Fe protein contacts; other site 640131005547 MoFe protein dimer/ dimer interactions; other site 640131005548 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 640131005549 nitrogenase iron protein; Region: nifH; TIGR01287 640131005550 Nucleotide-binding sites [chemical binding]; other site 640131005551 Walker A motif; other site 640131005552 Switch I region of nucleotide binding site; other site 640131005553 Fe4S4 binding sites [ion binding]; other site 640131005554 Switch II region of nucleotide binding site; other site 640131005555 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 640131005556 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 640131005557 dimer interface [polypeptide binding]; other site 640131005558 PYR/PP interface [polypeptide binding]; other site 640131005559 TPP binding site [chemical binding]; other site 640131005560 substrate binding site [chemical binding]; other site 640131005561 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 640131005562 Domain of unknown function; Region: EKR; pfam10371 640131005563 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131005564 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 640131005565 TPP-binding site [chemical binding]; other site 640131005566 dimer interface [polypeptide binding]; other site 640131005567 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131005568 dimerization interface [polypeptide binding]; other site 640131005569 putative DNA binding site [nucleotide binding]; other site 640131005570 putative Zn2+ binding site [ion binding]; other site 640131005571 elongation factor G; Reviewed; Region: PRK00007 640131005572 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 640131005573 G1 box; other site 640131005574 putative GEF interaction site [polypeptide binding]; other site 640131005575 GTP/Mg2+ binding site [chemical binding]; other site 640131005576 Switch I region; other site 640131005577 G2 box; other site 640131005578 G3 box; other site 640131005579 Switch II region; other site 640131005580 G4 box; other site 640131005581 G5 box; other site 640131005582 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 640131005583 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 640131005584 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 640131005585 exonuclease I; Provisional; Region: sbcB; PRK11779 640131005586 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 640131005587 active site 640131005588 catalytic site [active] 640131005589 substrate binding site [chemical binding]; other site 640131005590 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 640131005591 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 640131005592 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 640131005593 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 640131005594 DNA gyrase inhibitor; Provisional; Region: PRK10016 640131005595 Predicted membrane protein [Function unknown]; Region: COG1289 640131005596 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 640131005597 hypothetical protein; Provisional; Region: PRK05423 640131005598 cobalamin synthase; Reviewed; Region: cobS; PRK00235 640131005599 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 640131005600 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 640131005601 putative dimer interface [polypeptide binding]; other site 640131005602 active site pocket [active] 640131005603 putative cataytic base [active] 640131005604 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 640131005605 NAD binding site [chemical binding]; other site 640131005606 HPP family; Region: HPP; pfam04982 640131005607 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 640131005608 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131005609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005610 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131005611 putative effector binding pocket; other site 640131005612 dimerization interface [polypeptide binding]; other site 640131005613 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 640131005614 shikimate transporter; Provisional; Region: PRK09952 640131005615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005616 putative substrate translocation pore; other site 640131005617 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 640131005618 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131005619 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131005620 metal binding site [ion binding]; metal-binding site 640131005621 active site 640131005622 I-site; other site 640131005623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131005624 Domain of unknown function (DUF1971); Region: DUF1971; cl17717 640131005625 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 640131005626 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 640131005627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005628 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 640131005629 dimerization interface [polypeptide binding]; other site 640131005630 substrate binding pocket [chemical binding]; other site 640131005631 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 640131005632 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 640131005633 TAP-like protein; Region: Abhydrolase_4; pfam08386 640131005634 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 640131005635 GAF domain; Region: GAF; pfam01590 640131005636 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131005637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131005638 metal binding site [ion binding]; metal-binding site 640131005639 active site 640131005640 I-site; other site 640131005641 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 640131005642 active site 640131005643 substrate binding site [chemical binding]; other site 640131005644 ATP binding site [chemical binding]; other site 640131005645 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 640131005646 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131005647 Walker A/P-loop; other site 640131005648 ATP binding site [chemical binding]; other site 640131005649 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 640131005650 putative active site [active] 640131005651 putative metal-binding site [ion binding]; other site 640131005652 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 640131005653 Part of AAA domain; Region: AAA_19; pfam13245 640131005654 Family description; Region: UvrD_C_2; pfam13538 640131005655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131005656 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 640131005657 Walker A motif; other site 640131005658 ATP binding site [chemical binding]; other site 640131005659 Walker B motif; other site 640131005660 arginine finger; other site 640131005661 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 640131005662 PemK-like protein; Region: PemK; cl00995 640131005663 MATE family multidrug exporter; Provisional; Region: PRK10189 640131005664 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 640131005665 AMP nucleosidase; Provisional; Region: PRK08292 640131005666 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 640131005667 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 640131005668 signal transduction protein PmrD; Provisional; Region: PRK15450 640131005669 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 640131005670 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 640131005671 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 640131005672 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 640131005673 NADP binding site [chemical binding]; other site 640131005674 dimer interface [polypeptide binding]; other site 640131005675 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131005676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131005677 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 640131005678 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 640131005679 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 640131005680 serine O-acetyltransferase; Region: cysE; TIGR01172 640131005681 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 640131005682 trimer interface [polypeptide binding]; other site 640131005683 active site 640131005684 substrate binding site [chemical binding]; other site 640131005685 CoA binding site [chemical binding]; other site 640131005686 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 640131005687 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 640131005688 dimer interface [polypeptide binding]; other site 640131005689 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131005690 catalytic residue [active] 640131005691 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 640131005692 MPN+ (JAMM) motif; other site 640131005693 Zinc-binding site [ion binding]; other site 640131005694 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 640131005695 MoaE interaction surface [polypeptide binding]; other site 640131005696 MoeB interaction surface [polypeptide binding]; other site 640131005697 thiocarboxylated glycine; other site 640131005698 hypothetical protein; Validated; Region: PRK07411 640131005699 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 640131005700 ATP binding site [chemical binding]; other site 640131005701 substrate interface [chemical binding]; other site 640131005702 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 640131005703 active site residue [active] 640131005704 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 640131005705 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 640131005706 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 640131005707 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131005708 catalytic residue [active] 640131005709 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 640131005710 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005711 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 640131005712 putative dimerization interface [polypeptide binding]; other site 640131005713 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 640131005714 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131005715 dimerization interface [polypeptide binding]; other site 640131005716 L,D-transpeptidase; Provisional; Region: PRK10190 640131005717 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 640131005718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131005719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131005720 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131005721 putative effector binding pocket; other site 640131005722 putative dimerization interface [polypeptide binding]; other site 640131005723 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 640131005724 homotrimer interaction site [polypeptide binding]; other site 640131005725 putative active site [active] 640131005726 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 640131005727 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 640131005728 NAD(P) binding site [chemical binding]; other site 640131005729 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131005730 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131005731 substrate binding pocket [chemical binding]; other site 640131005732 membrane-bound complex binding site; other site 640131005733 hinge residues; other site 640131005734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131005735 dimer interface [polypeptide binding]; other site 640131005736 conserved gate region; other site 640131005737 putative PBP binding loops; other site 640131005738 ABC-ATPase subunit interface; other site 640131005739 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131005740 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131005741 Walker A/P-loop; other site 640131005742 ATP binding site [chemical binding]; other site 640131005743 Q-loop/lid; other site 640131005744 ABC transporter signature motif; other site 640131005745 Walker B; other site 640131005746 D-loop; other site 640131005747 H-loop/switch region; other site 640131005748 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 640131005749 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 640131005750 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131005751 metal binding site [ion binding]; metal-binding site 640131005752 dimer interface [polypeptide binding]; other site 640131005753 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 640131005754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131005755 Coenzyme A binding pocket [chemical binding]; other site 640131005756 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 640131005757 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 640131005758 tetramer interface [polypeptide binding]; other site 640131005759 active site 640131005760 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 640131005761 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 640131005762 putative active site [active] 640131005763 metal binding site [ion binding]; metal-binding site 640131005764 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 640131005765 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 640131005766 active site 640131005767 non-prolyl cis peptide bond; other site 640131005768 aspartate aminotransferase; Provisional; Region: PRK06107 640131005769 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131005770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131005771 homodimer interface [polypeptide binding]; other site 640131005772 catalytic residue [active] 640131005773 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 640131005774 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 640131005775 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 640131005776 trimer interface [polypeptide binding]; other site 640131005777 eyelet of channel; other site 640131005778 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 640131005779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131005780 Zn2+ binding site [ion binding]; other site 640131005781 Mg2+ binding site [ion binding]; other site 640131005782 DNA cytosine methylase; Provisional; Region: PRK10458 640131005783 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 640131005784 cofactor binding site; other site 640131005785 DNA binding site [nucleotide binding] 640131005786 substrate interaction site [chemical binding]; other site 640131005787 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 640131005788 additional DNA contacts [nucleotide binding]; other site 640131005789 mismatch recognition site; other site 640131005790 active site 640131005791 zinc binding site [ion binding]; other site 640131005792 DNA intercalation site [nucleotide binding]; other site 640131005793 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 640131005794 EamA-like transporter family; Region: EamA; pfam00892 640131005795 hypothetical protein; Provisional; Region: PRK10062 640131005796 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 640131005797 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131005798 metal binding site [ion binding]; metal-binding site 640131005799 active site 640131005800 I-site; other site 640131005801 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 640131005802 hypothetical protein; Provisional; Region: PRK10708 640131005803 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 640131005804 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131005805 DNA binding residues [nucleotide binding] 640131005806 dimerization interface [polypeptide binding]; other site 640131005807 lipoprotein; Provisional; Region: PRK10397 640131005808 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 640131005809 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 640131005810 active site 640131005811 Na/Ca binding site [ion binding]; other site 640131005812 catalytic site [active] 640131005813 cystine transporter subunit; Provisional; Region: PRK11260 640131005814 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131005815 substrate binding pocket [chemical binding]; other site 640131005816 membrane-bound complex binding site; other site 640131005817 hinge residues; other site 640131005818 D-cysteine desulfhydrase; Validated; Region: PRK03910 640131005819 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 640131005820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131005821 catalytic residue [active] 640131005822 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131005823 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131005824 dimer interface [polypeptide binding]; other site 640131005825 conserved gate region; other site 640131005826 putative PBP binding loops; other site 640131005827 ABC-ATPase subunit interface; other site 640131005828 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 640131005829 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131005830 Walker A/P-loop; other site 640131005831 ATP binding site [chemical binding]; other site 640131005832 Q-loop/lid; other site 640131005833 ABC transporter signature motif; other site 640131005834 Walker B; other site 640131005835 D-loop; other site 640131005836 H-loop/switch region; other site 640131005837 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 640131005838 Autoinducer binding domain; Region: Autoind_bind; pfam03472 640131005839 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131005840 DNA binding residues [nucleotide binding] 640131005841 dimerization interface [polypeptide binding]; other site 640131005842 hypothetical protein; Provisional; Region: PRK10613 640131005843 response regulator; Provisional; Region: PRK09483 640131005844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131005845 active site 640131005846 phosphorylation site [posttranslational modification] 640131005847 intermolecular recognition site; other site 640131005848 dimerization interface [polypeptide binding]; other site 640131005849 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131005850 DNA binding residues [nucleotide binding] 640131005851 dimerization interface [polypeptide binding]; other site 640131005852 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 640131005853 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 640131005854 GIY-YIG motif/motif A; other site 640131005855 active site 640131005856 catalytic site [active] 640131005857 putative DNA binding site [nucleotide binding]; other site 640131005858 metal binding site [ion binding]; metal-binding site 640131005859 UvrB/uvrC motif; Region: UVR; pfam02151 640131005860 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 640131005861 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 640131005862 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 640131005863 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 640131005864 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 640131005865 inhibitor site; inhibition site 640131005866 active site 640131005867 dimer interface [polypeptide binding]; other site 640131005868 catalytic residue [active] 640131005869 hypothetical protein; Provisional; Region: PRK10396 640131005870 yecA family protein; Region: ygfB_yecA; TIGR02292 640131005871 SEC-C motif; Region: SEC-C; pfam02810 640131005872 tyrosine transporter TyrP; Provisional; Region: PRK15132 640131005873 aromatic amino acid transport protein; Region: araaP; TIGR00837 640131005874 probable metal-binding protein; Region: matur_matur; TIGR03853 640131005875 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 640131005876 Ferritin-like domain; Region: Ferritin; pfam00210 640131005877 ferroxidase diiron center [ion binding]; other site 640131005878 hypothetical protein; Provisional; Region: PRK09273 640131005879 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 640131005880 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 640131005881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131005883 putative substrate translocation pore; other site 640131005884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005885 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 640131005886 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 640131005887 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 640131005888 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 640131005889 Ferritin-like domain; Region: Ferritin; pfam00210 640131005890 ferroxidase diiron center [ion binding]; other site 640131005891 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 640131005892 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 640131005893 ligand binding site [chemical binding]; other site 640131005894 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 640131005895 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131005896 Walker A/P-loop; other site 640131005897 ATP binding site [chemical binding]; other site 640131005898 Q-loop/lid; other site 640131005899 ABC transporter signature motif; other site 640131005900 Walker B; other site 640131005901 D-loop; other site 640131005902 H-loop/switch region; other site 640131005903 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131005904 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131005905 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131005906 TM-ABC transporter signature motif; other site 640131005907 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 640131005908 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 640131005909 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 640131005910 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 640131005911 active site 640131005912 homotetramer interface [polypeptide binding]; other site 640131005913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131005914 Ligand Binding Site [chemical binding]; other site 640131005915 MFS/sugar transport protein; Region: MFS_2; pfam13347 640131005916 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131005917 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 640131005918 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 640131005919 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 640131005920 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 640131005921 active site 640131005922 HIGH motif; other site 640131005923 KMSK motif region; other site 640131005924 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 640131005925 tRNA binding surface [nucleotide binding]; other site 640131005926 anticodon binding site; other site 640131005927 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 640131005928 putative metal binding site [ion binding]; other site 640131005929 copper homeostasis protein CutC; Provisional; Region: PRK11572 640131005930 Methyltransferase domain; Region: Methyltransf_23; pfam13489 640131005931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131005932 S-adenosylmethionine binding site [chemical binding]; other site 640131005933 Methyltransferase domain; Region: Methyltransf_31; pfam13847 640131005934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131005935 S-adenosylmethionine binding site [chemical binding]; other site 640131005936 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 640131005937 hypothetical protein; Provisional; Region: PRK10302 640131005938 Isochorismatase family; Region: Isochorismatase; pfam00857 640131005939 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 640131005940 catalytic triad [active] 640131005941 conserved cis-peptide bond; other site 640131005942 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 640131005943 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 640131005944 dimer interface [polypeptide binding]; other site 640131005945 anticodon binding site; other site 640131005946 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 640131005947 homodimer interface [polypeptide binding]; other site 640131005948 motif 1; other site 640131005949 active site 640131005950 motif 2; other site 640131005951 GAD domain; Region: GAD; pfam02938 640131005952 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 640131005953 active site 640131005954 motif 3; other site 640131005955 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 640131005956 nudix motif; other site 640131005957 hypothetical protein; Validated; Region: PRK00110 640131005958 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 640131005959 active site 640131005960 putative DNA-binding cleft [nucleotide binding]; other site 640131005961 dimer interface [polypeptide binding]; other site 640131005962 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 640131005963 RuvA N terminal domain; Region: RuvA_N; pfam01330 640131005964 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 640131005965 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 640131005966 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131005967 Walker A motif; other site 640131005968 ATP binding site [chemical binding]; other site 640131005969 Walker B motif; other site 640131005970 arginine finger; other site 640131005971 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 640131005972 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 640131005973 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131005974 ABC-ATPase subunit interface; other site 640131005975 dimer interface [polypeptide binding]; other site 640131005976 putative PBP binding regions; other site 640131005977 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 640131005978 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 640131005979 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 640131005980 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 640131005981 metal binding site [ion binding]; metal-binding site 640131005982 putative peptidase; Provisional; Region: PRK11649 640131005983 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 640131005984 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131005985 Peptidase family M23; Region: Peptidase_M23; pfam01551 640131005986 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 640131005987 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 640131005988 putative acyl-acceptor binding pocket; other site 640131005989 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 640131005990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131005991 active site 640131005992 phosphorylation site [posttranslational modification] 640131005993 intermolecular recognition site; other site 640131005994 dimerization interface [polypeptide binding]; other site 640131005995 malate dehydrogenase; Provisional; Region: PRK13529 640131005996 Malic enzyme, N-terminal domain; Region: malic; pfam00390 640131005997 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 640131005998 NAD(P) binding site [chemical binding]; other site 640131005999 Predicted permeases [General function prediction only]; Region: COG0679 640131006000 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 640131006001 pyruvate kinase; Provisional; Region: PRK05826 640131006002 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 640131006003 domain interfaces; other site 640131006004 active site 640131006005 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 640131006006 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131006007 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 640131006008 putative active site [active] 640131006009 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 640131006010 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 640131006011 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 640131006012 phosphogluconate dehydratase; Validated; Region: PRK09054 640131006013 6-phosphogluconate dehydratase; Region: edd; TIGR01196 640131006014 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 640131006015 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 640131006016 active site 640131006017 intersubunit interface [polypeptide binding]; other site 640131006018 catalytic residue [active] 640131006019 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 640131006020 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 640131006021 ATP-grasp domain; Region: ATP-grasp; pfam02222 640131006022 YebG protein; Region: YebG; pfam07130 640131006023 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 640131006024 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 640131006025 putative metal binding site [ion binding]; other site 640131006026 protease 2; Provisional; Region: PRK10115 640131006027 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 640131006028 exodeoxyribonuclease X; Provisional; Region: PRK07983 640131006029 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 640131006030 active site 640131006031 catalytic site [active] 640131006032 substrate binding site [chemical binding]; other site 640131006033 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 640131006034 CopC domain; Region: CopC; cl01012 640131006035 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 640131006036 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 640131006037 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 640131006038 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 640131006039 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 640131006040 active site 640131006041 DNA binding site [nucleotide binding] 640131006042 Int/Topo IB signature motif; other site 640131006043 Excisionase-like protein; Region: Exc; pfam07825 640131006044 DNA polymerase III, theta subunit; Region: DNA_pol3_theta; pfam06440 640131006045 Siphovirus Gp157; Region: Sipho_Gp157; pfam05565 640131006046 RecT family; Region: RecT; pfam03837 640131006047 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 640131006048 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 640131006049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131006050 non-specific DNA binding site [nucleotide binding]; other site 640131006051 salt bridge; other site 640131006052 sequence-specific DNA binding site [nucleotide binding]; other site 640131006053 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 640131006054 Catalytic site [active] 640131006055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131006056 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131006057 non-specific DNA binding site [nucleotide binding]; other site 640131006058 salt bridge; other site 640131006059 sequence-specific DNA binding site [nucleotide binding]; other site 640131006060 Bacteriophage CII protein; Region: Phage_CII; pfam05269 640131006061 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 640131006062 phage replicative helicase, DnaB family, HK022 subfamily; Region: phage_DnaB; TIGR03600 640131006063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 640131006064 Walker A motif; other site 640131006065 ATP binding site [chemical binding]; other site 640131006066 Walker B motif; other site 640131006067 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 640131006068 putative DNA binding helix; other site 640131006069 hypothetical protein; Provisional; Region: PRK09741 640131006070 NINE Protein; Region: NinE; pfam05322 640131006071 NinF protein; Region: NinF; pfam05810 640131006072 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 640131006073 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 640131006074 Phage NinH protein; Region: Phage_NinH; pfam06322 640131006075 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 640131006076 catalytic residues [active] 640131006077 Terminase-like family; Region: Terminase_6; pfam03237 640131006078 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 640131006079 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 640131006080 KilA-N domain; Region: KilA-N; pfam04383 640131006081 Phage-related minor tail protein [Function unknown]; Region: COG5281 640131006082 tape measure domain; Region: tape_meas_nterm; TIGR02675 640131006083 ThiS family; Region: ThiS; pfam02597 640131006084 charged pocket; other site 640131006085 hydrophobic patch; other site 640131006086 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 640131006087 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 640131006088 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 640131006089 active site 640131006090 DNA binding site [nucleotide binding] 640131006091 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 640131006092 hypothetical protein; Provisional; Region: PRK09951 640131006093 Protein of unknown function (DUF535); Region: DUF535; pfam04393 640131006094 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 640131006095 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 640131006096 active site 640131006097 metal binding site [ion binding]; metal-binding site 640131006098 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 640131006099 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 640131006100 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 640131006101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131006102 S-adenosylmethionine binding site [chemical binding]; other site 640131006103 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 640131006104 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 640131006105 mce related protein; Region: MCE; pfam02470 640131006106 mce related protein; Region: MCE; pfam02470 640131006107 mce related protein; Region: MCE; pfam02470 640131006108 mce related protein; Region: MCE; pfam02470 640131006109 mce related protein; Region: MCE; pfam02470 640131006110 mce related protein; Region: MCE; pfam02470 640131006111 Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995 640131006112 Paraquat-inducible protein A; Region: PqiA; pfam04403 640131006113 Paraquat-inducible protein A; Region: PqiA; pfam04403 640131006114 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 640131006115 GAF domain; Region: GAF_2; pfam13185 640131006116 ProP expression regulator; Provisional; Region: PRK04950 640131006117 ProQ/FINO family; Region: ProQ; pfam04352 640131006118 carboxy-terminal protease; Provisional; Region: PRK11186 640131006119 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 640131006120 protein binding site [polypeptide binding]; other site 640131006121 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 640131006122 Catalytic dyad [active] 640131006123 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 640131006124 heat shock protein HtpX; Provisional; Region: PRK05457 640131006125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131006126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131006127 putative substrate translocation pore; other site 640131006128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131006129 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 640131006130 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131006131 dimerization interface [polypeptide binding]; other site 640131006132 putative Zn2+ binding site [ion binding]; other site 640131006133 putative DNA binding site [nucleotide binding]; other site 640131006134 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131006135 YobH-like protein; Region: YobH; pfam13996 640131006136 PhoPQ regulatory protein; Provisional; Region: PRK10299 640131006137 YebO-like protein; Region: YebO; pfam13974 640131006138 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 640131006139 DNA-binding site [nucleotide binding]; DNA binding site 640131006140 RNA-binding motif; other site 640131006141 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 640131006142 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 640131006143 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 640131006144 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 640131006145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131006146 S-adenosylmethionine binding site [chemical binding]; other site 640131006147 hypothetical protein; Provisional; Region: PRK11469 640131006148 Domain of unknown function DUF; Region: DUF204; pfam02659 640131006149 Domain of unknown function DUF; Region: DUF204; pfam02659 640131006150 hypothetical protein; Provisional; Region: PRK02913 640131006151 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 640131006152 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 640131006153 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 640131006154 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 640131006155 active pocket/dimerization site; other site 640131006156 active site 640131006157 phosphorylation site [posttranslational modification] 640131006158 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 640131006159 active site 640131006160 phosphorylation site [posttranslational modification] 640131006161 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 640131006162 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 640131006163 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 640131006164 Transporter associated domain; Region: CorC_HlyC; smart01091 640131006165 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 640131006166 phage resistance protein; Provisional; Region: PRK10551 640131006167 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131006168 L-serine deaminase; Provisional; Region: PRK15023 640131006169 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 640131006170 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 640131006171 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 640131006172 putative active site [active] 640131006173 putative CoA binding site [chemical binding]; other site 640131006174 nudix motif; other site 640131006175 metal binding site [ion binding]; metal-binding site 640131006176 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 640131006177 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 640131006178 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 640131006179 hypothetical protein; Provisional; Region: PRK05114 640131006180 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 640131006181 Alginate lyase; Region: Alginate_lyase; pfam05426 640131006182 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 640131006183 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 640131006184 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131006185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006186 dimer interface [polypeptide binding]; other site 640131006187 putative PBP binding loops; other site 640131006188 ABC-ATPase subunit interface; other site 640131006189 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131006190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006191 dimer interface [polypeptide binding]; other site 640131006192 conserved gate region; other site 640131006193 putative PBP binding loops; other site 640131006194 ABC-ATPase subunit interface; other site 640131006195 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 640131006196 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131006197 Walker A/P-loop; other site 640131006198 ATP binding site [chemical binding]; other site 640131006199 Q-loop/lid; other site 640131006200 ABC transporter signature motif; other site 640131006201 Walker B; other site 640131006202 D-loop; other site 640131006203 H-loop/switch region; other site 640131006204 TOBE domain; Region: TOBE_2; pfam08402 640131006205 Alginate lyase; Region: Alginate_lyase; pfam05426 640131006206 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 640131006207 homotrimer interaction site [polypeptide binding]; other site 640131006208 putative active site [active] 640131006209 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 640131006210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 640131006211 DEAD_2; Region: DEAD_2; pfam06733 640131006212 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 640131006213 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 640131006214 Glycoprotease family; Region: Peptidase_M22; pfam00814 640131006215 Starvation-inducible outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: Slp; COG3065 640131006216 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 640131006217 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 640131006218 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 640131006219 acyl-activating enzyme (AAE) consensus motif; other site 640131006220 putative AMP binding site [chemical binding]; other site 640131006221 putative active site [active] 640131006222 putative CoA binding site [chemical binding]; other site 640131006223 ribonuclease D; Provisional; Region: PRK10829 640131006224 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 640131006225 catalytic site [active] 640131006226 putative active site [active] 640131006227 putative substrate binding site [chemical binding]; other site 640131006228 Helicase and RNase D C-terminal; Region: HRDC; smart00341 640131006229 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 640131006230 cell division inhibitor MinD; Provisional; Region: PRK10818 640131006231 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 640131006232 Switch I; other site 640131006233 Switch II; other site 640131006234 septum formation inhibitor; Reviewed; Region: minC; PRK03511 640131006235 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 640131006236 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 640131006237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 640131006238 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 640131006239 hypothetical protein; Provisional; Region: PRK10691 640131006240 hypothetical protein; Provisional; Region: PRK05170 640131006241 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 640131006242 disulfide bond formation protein B; Provisional; Region: PRK01749 640131006243 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 640131006244 transmembrane helices; other site 640131006245 fatty acid metabolism regulator; Provisional; Region: PRK04984 640131006246 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131006247 DNA-binding site [nucleotide binding]; DNA binding site 640131006248 FadR C-terminal domain; Region: FadR_C; pfam07840 640131006249 SpoVR family protein; Provisional; Region: PRK11767 640131006250 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 640131006251 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 640131006252 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 640131006253 hydroxyglutarate oxidase; Provisional; Region: PRK11728 640131006254 alanine racemase; Reviewed; Region: dadX; PRK03646 640131006255 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 640131006256 active site 640131006257 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 640131006258 substrate binding site [chemical binding]; other site 640131006259 catalytic residues [active] 640131006260 dimer interface [polypeptide binding]; other site 640131006261 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 640131006262 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 640131006263 TrkA-C domain; Region: TrkA_C; pfam02080 640131006264 Transporter associated domain; Region: CorC_HlyC; smart01091 640131006265 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 640131006266 dimer interface [polypeptide binding]; other site 640131006267 catalytic triad [active] 640131006268 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 640131006269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131006270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131006271 catalytic residue [active] 640131006272 TIGR04222 domain; Region: near_uncomplex 640131006273 TIGR04222 domain; Region: near_uncomplex 640131006274 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 640131006275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131006276 N-terminal plug; other site 640131006277 ligand-binding site [chemical binding]; other site 640131006278 trehalase; Provisional; Region: treA; PRK13271 640131006279 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 640131006280 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 640131006281 Uncharacterized conserved protein [Function unknown]; Region: COG2308 640131006282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 640131006283 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 640131006284 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 640131006285 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 640131006286 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 640131006287 Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484 640131006288 Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765 640131006289 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 640131006290 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131006291 Walker A/P-loop; other site 640131006292 ATP binding site [chemical binding]; other site 640131006293 Q-loop/lid; other site 640131006294 ABC transporter signature motif; other site 640131006295 Walker B; other site 640131006296 D-loop; other site 640131006297 H-loop/switch region; other site 640131006298 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131006299 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 640131006300 ATP binding site [chemical binding]; other site 640131006301 substrate binding site [chemical binding]; other site 640131006302 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131006303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006304 dimer interface [polypeptide binding]; other site 640131006305 conserved gate region; other site 640131006306 putative PBP binding loops; other site 640131006307 ABC-ATPase subunit interface; other site 640131006308 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131006309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006310 dimer interface [polypeptide binding]; other site 640131006311 conserved gate region; other site 640131006312 putative PBP binding loops; other site 640131006313 ABC-ATPase subunit interface; other site 640131006314 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 640131006315 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 640131006316 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 640131006317 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131006318 nucleotide binding site [chemical binding]; other site 640131006319 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 640131006320 Fatty acid desaturase protein family subgroup, a delta-12 acyl-lipid desaturase-like, DesA-like, yet uncharacterized subgroup of membrane fatty acid desaturase proteins found in alpha-, beta-, and gamma-proteobacteria. Sequences of this domain family...; Region: DesA_FADS-like; cd03509 640131006321 putative di-iron ligands [ion binding]; other site 640131006322 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 640131006323 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 640131006324 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 640131006325 active site 640131006326 non-prolyl cis peptide bond; other site 640131006327 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 640131006328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006329 dimer interface [polypeptide binding]; other site 640131006330 conserved gate region; other site 640131006331 ABC-ATPase subunit interface; other site 640131006332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 640131006333 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 640131006334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131006335 Walker A/P-loop; other site 640131006336 ATP binding site [chemical binding]; other site 640131006337 Q-loop/lid; other site 640131006338 ABC transporter signature motif; other site 640131006339 Walker B; other site 640131006340 D-loop; other site 640131006341 H-loop/switch region; other site 640131006342 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 640131006343 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131006344 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131006345 dimerization interface [polypeptide binding]; other site 640131006346 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 640131006347 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 640131006348 tetramer interface [polypeptide binding]; other site 640131006349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131006350 catalytic residue [active] 640131006351 threonine/serine transporter TdcC; Provisional; Region: PRK13629 640131006352 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 640131006353 propionate/acetate kinase; Provisional; Region: PRK12379 640131006354 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 640131006355 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 640131006356 Pyruvate formate lyase 1; Region: PFL1; cd01678 640131006357 coenzyme A binding site [chemical binding]; other site 640131006358 active site 640131006359 catalytic residues [active] 640131006360 glycine loop; other site 640131006361 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 640131006362 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 640131006363 dimerization interface [polypeptide binding]; other site 640131006364 ligand binding site [chemical binding]; other site 640131006365 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131006366 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 640131006367 TM-ABC transporter signature motif; other site 640131006368 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 640131006369 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 640131006370 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 640131006371 TM-ABC transporter signature motif; other site 640131006372 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 640131006373 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 640131006374 Walker A/P-loop; other site 640131006375 ATP binding site [chemical binding]; other site 640131006376 Q-loop/lid; other site 640131006377 ABC transporter signature motif; other site 640131006378 Walker B; other site 640131006379 D-loop; other site 640131006380 H-loop/switch region; other site 640131006381 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 640131006382 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 640131006383 Walker A/P-loop; other site 640131006384 ATP binding site [chemical binding]; other site 640131006385 Q-loop/lid; other site 640131006386 ABC transporter signature motif; other site 640131006387 Walker B; other site 640131006388 D-loop; other site 640131006389 H-loop/switch region; other site 640131006390 cell density-dependent motility repressor; Provisional; Region: PRK10082 640131006391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131006392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131006393 dimerization interface [polypeptide binding]; other site 640131006394 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 640131006395 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 640131006396 active site 640131006397 substrate-binding site [chemical binding]; other site 640131006398 metal-binding site [ion binding] 640131006399 ATP binding site [chemical binding]; other site 640131006400 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131006401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131006402 Coenzyme A binding pocket [chemical binding]; other site 640131006403 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131006404 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131006405 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131006406 dimerization interface [polypeptide binding]; other site 640131006407 citrate-proton symporter; Provisional; Region: PRK15075 640131006408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131006409 putative substrate translocation pore; other site 640131006410 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 640131006411 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 640131006412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131006413 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131006414 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 640131006415 putative dimerization interface [polypeptide binding]; other site 640131006416 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 640131006417 DNA-binding site [nucleotide binding]; DNA binding site 640131006418 RNA-binding motif; other site 640131006419 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 640131006420 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 640131006421 active site 640131006422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 640131006423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131006424 DNA-binding site [nucleotide binding]; DNA binding site 640131006425 Transcriptional regulators [Transcription]; Region: FadR; COG2186 640131006426 FCD domain; Region: FCD; pfam07729 640131006427 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 640131006428 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 640131006429 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 640131006430 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 640131006431 active site 640131006432 intersubunit interface [polypeptide binding]; other site 640131006433 catalytic residue [active] 640131006434 galactonate dehydratase; Provisional; Region: PRK14017 640131006435 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 640131006436 putative active site pocket [active] 640131006437 putative metal binding site [ion binding]; other site 640131006438 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 640131006439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131006440 putative substrate translocation pore; other site 640131006441 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 640131006442 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 640131006443 putative ligand binding site [chemical binding]; other site 640131006444 NAD binding site [chemical binding]; other site 640131006445 catalytic site [active] 640131006446 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 640131006447 putative active site pocket [active] 640131006448 dimerization interface [polypeptide binding]; other site 640131006449 putative catalytic residue [active] 640131006450 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 640131006451 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 640131006452 ImpA domain protein; Region: DUF3702; pfam12486 640131006453 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 640131006454 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 640131006455 putative ligand binding site [chemical binding]; other site 640131006456 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 640131006457 GTP-binding protein YchF; Reviewed; Region: PRK09601 640131006458 YchF GTPase; Region: YchF; cd01900 640131006459 G1 box; other site 640131006460 GTP/Mg2+ binding site [chemical binding]; other site 640131006461 Switch I region; other site 640131006462 G2 box; other site 640131006463 Switch II region; other site 640131006464 G3 box; other site 640131006465 G4 box; other site 640131006466 G5 box; other site 640131006467 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 640131006468 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 640131006469 putative active site [active] 640131006470 catalytic residue [active] 640131006471 hypothetical protein; Provisional; Region: PRK10692 640131006472 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 640131006473 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 640131006474 DNA binding residues [nucleotide binding] 640131006475 putative dimer interface [polypeptide binding]; other site 640131006476 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 640131006477 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 640131006478 putative transporter; Provisional; Region: PRK11660 640131006479 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 640131006480 Sulfate transporter family; Region: Sulfate_transp; pfam00916 640131006481 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 640131006482 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 640131006483 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 640131006484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131006485 active site 640131006486 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 640131006487 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 640131006488 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 640131006489 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 640131006490 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 640131006491 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 640131006492 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 640131006493 tRNA; other site 640131006494 putative tRNA binding site [nucleotide binding]; other site 640131006495 putative NADP binding site [chemical binding]; other site 640131006496 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 640131006497 peptide chain release factor 1; Validated; Region: prfA; PRK00591 640131006498 This domain is found in peptide chain release factors; Region: PCRF; smart00937 640131006499 RF-1 domain; Region: RF-1; pfam00472 640131006500 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 640131006501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131006502 hypothetical protein; Provisional; Region: PRK10278 640131006503 hypothetical protein; Provisional; Region: PRK10941 640131006504 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 640131006505 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 640131006506 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 640131006507 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 640131006508 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 640131006509 cation transport regulator; Reviewed; Region: chaB; PRK09582 640131006510 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 640131006511 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 640131006512 putative active site pocket [active] 640131006513 dimerization interface [polypeptide binding]; other site 640131006514 putative catalytic residue [active] 640131006515 Domain of unknown function (DUF1883); Region: DUF1883; pfam08980 640131006516 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 640131006517 Nitrate and nitrite sensing; Region: NIT; pfam08376 640131006518 ANTAR domain; Region: ANTAR; pfam03861 640131006519 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 640131006520 NMT1-like family; Region: NMT1_2; pfam13379 640131006521 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006523 dimer interface [polypeptide binding]; other site 640131006524 conserved gate region; other site 640131006525 putative PBP binding loops; other site 640131006526 ABC-ATPase subunit interface; other site 640131006527 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 640131006528 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131006529 Walker A/P-loop; other site 640131006530 ATP binding site [chemical binding]; other site 640131006531 Q-loop/lid; other site 640131006532 ABC transporter signature motif; other site 640131006533 Walker B; other site 640131006534 D-loop; other site 640131006535 H-loop/switch region; other site 640131006536 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 640131006537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131006538 nitrite reductase subunit NirD; Provisional; Region: PRK14989 640131006539 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131006540 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 640131006541 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 640131006542 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 640131006543 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 640131006544 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 640131006545 [4Fe-4S] binding site [ion binding]; other site 640131006546 molybdopterin cofactor binding site; other site 640131006547 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 640131006548 molybdopterin cofactor binding site; other site 640131006549 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 640131006550 putative invasin; Provisional; Region: PRK10177 640131006551 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 640131006552 transcriptional regulator NarL; Provisional; Region: PRK10651 640131006553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131006554 active site 640131006555 phosphorylation site [posttranslational modification] 640131006556 intermolecular recognition site; other site 640131006557 dimerization interface [polypeptide binding]; other site 640131006558 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131006559 DNA binding residues [nucleotide binding] 640131006560 dimerization interface [polypeptide binding]; other site 640131006561 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 640131006562 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 640131006563 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131006564 dimerization interface [polypeptide binding]; other site 640131006565 Histidine kinase; Region: HisKA_3; pfam07730 640131006566 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131006567 ATP binding site [chemical binding]; other site 640131006568 Mg2+ binding site [ion binding]; other site 640131006569 G-X-G motif; other site 640131006570 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 640131006571 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 640131006572 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 640131006573 [4Fe-4S] binding site [ion binding]; other site 640131006574 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131006575 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131006576 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131006577 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 640131006578 molybdopterin cofactor binding site; other site 640131006579 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 640131006580 4Fe-4S binding domain; Region: Fer4; cl02805 640131006581 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 640131006582 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 640131006583 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 640131006584 EamA-like transporter family; Region: EamA; pfam00892 640131006585 EamA-like transporter family; Region: EamA; pfam00892 640131006586 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 640131006587 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 640131006588 AsnC family; Region: AsnC_trans_reg; pfam01037 640131006589 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 640131006590 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 640131006591 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 640131006592 putative active site [active] 640131006593 putative substrate binding site [chemical binding]; other site 640131006594 putative cosubstrate binding site; other site 640131006595 catalytic site [active] 640131006596 SEC-C motif; Region: SEC-C; pfam02810 640131006597 hypothetical protein; Provisional; Region: PRK04233 640131006598 hypothetical protein; Provisional; Region: PRK10279 640131006599 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 640131006600 nucleophile elbow; other site 640131006601 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131006602 active site 640131006603 response regulator of RpoS; Provisional; Region: PRK10693 640131006604 phosphorylation site [posttranslational modification] 640131006605 intermolecular recognition site; other site 640131006606 dimerization interface [polypeptide binding]; other site 640131006607 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 640131006608 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 640131006609 active site 640131006610 tetramer interface; other site 640131006611 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 640131006612 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 640131006613 thymidine kinase; Provisional; Region: PRK04296 640131006614 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 640131006615 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 640131006616 putative catalytic cysteine [active] 640131006617 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 640131006618 putative active site [active] 640131006619 metal binding site [ion binding]; metal-binding site 640131006620 hypothetical protein; Provisional; Region: PRK11111 640131006621 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 640131006622 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 640131006623 peptide binding site [polypeptide binding]; other site 640131006624 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 640131006625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006626 dimer interface [polypeptide binding]; other site 640131006627 conserved gate region; other site 640131006628 putative PBP binding loops; other site 640131006629 ABC-ATPase subunit interface; other site 640131006630 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 640131006631 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131006632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131006633 dimer interface [polypeptide binding]; other site 640131006634 conserved gate region; other site 640131006635 ABC-ATPase subunit interface; other site 640131006636 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 640131006637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131006638 Walker A/P-loop; other site 640131006639 ATP binding site [chemical binding]; other site 640131006640 Q-loop/lid; other site 640131006641 ABC transporter signature motif; other site 640131006642 Walker B; other site 640131006643 D-loop; other site 640131006644 H-loop/switch region; other site 640131006645 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 640131006646 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 640131006647 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131006648 Walker A/P-loop; other site 640131006649 ATP binding site [chemical binding]; other site 640131006650 Q-loop/lid; other site 640131006651 ABC transporter signature motif; other site 640131006652 Walker B; other site 640131006653 D-loop; other site 640131006654 H-loop/switch region; other site 640131006655 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 640131006656 Ion transport protein; Region: Ion_trans; pfam00520 640131006657 Ion channel; Region: Ion_trans_2; pfam07885 640131006658 dsDNA-mimic protein; Reviewed; Region: PRK05094 640131006659 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 640131006660 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 640131006661 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 640131006662 putative active site [active] 640131006663 catalytic site [active] 640131006664 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 640131006665 putative active site [active] 640131006666 catalytic site [active] 640131006667 Uncharacterized conserved protein [Function unknown]; Region: COG2353 640131006668 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 640131006669 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 640131006670 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 640131006671 Trp docking motif [polypeptide binding]; other site 640131006672 putative active site [active] 640131006673 YciI-like protein; Reviewed; Region: PRK11370 640131006674 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 640131006675 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 640131006676 Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767 640131006677 catalytic residues [active] 640131006678 catalytic nucleophile [active] 640131006679 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 640131006680 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 640131006681 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 640131006682 catalytic residues [active] 640131006683 catalytic nucleophile [active] 640131006684 Recombinase; Region: Recombinase; pfam07508 640131006685 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 640131006686 transport protein TonB; Provisional; Region: PRK10819 640131006687 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 640131006688 Phosphotransferase enzyme family; Region: APH; pfam01636 640131006689 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 640131006690 active site 640131006691 ATP binding site [chemical binding]; other site 640131006692 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 640131006693 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 640131006694 6-phosphofructokinase 2; Provisional; Region: PRK10294 640131006695 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 640131006696 putative substrate binding site [chemical binding]; other site 640131006697 putative ATP binding site [chemical binding]; other site 640131006698 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 640131006699 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 640131006700 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 640131006701 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 640131006702 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 640131006703 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 640131006704 active site 640131006705 dimer interface [polypeptide binding]; other site 640131006706 motif 1; other site 640131006707 motif 2; other site 640131006708 motif 3; other site 640131006709 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 640131006710 anticodon binding site; other site 640131006711 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 640131006712 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 640131006713 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 640131006714 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 640131006715 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 640131006716 23S rRNA binding site [nucleotide binding]; other site 640131006717 L21 binding site [polypeptide binding]; other site 640131006718 L13 binding site [polypeptide binding]; other site 640131006719 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 640131006720 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 640131006721 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 640131006722 dimer interface [polypeptide binding]; other site 640131006723 motif 1; other site 640131006724 active site 640131006725 motif 2; other site 640131006726 motif 3; other site 640131006727 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 640131006728 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 640131006729 putative tRNA-binding site [nucleotide binding]; other site 640131006730 B3/4 domain; Region: B3_4; pfam03483 640131006731 tRNA synthetase B5 domain; Region: B5; smart00874 640131006732 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 640131006733 dimer interface [polypeptide binding]; other site 640131006734 motif 1; other site 640131006735 motif 3; other site 640131006736 motif 2; other site 640131006737 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 640131006738 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 640131006739 IHF dimer interface [polypeptide binding]; other site 640131006740 IHF - DNA interface [nucleotide binding]; other site 640131006741 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 640131006742 homotrimer interaction site [polypeptide binding]; other site 640131006743 putative active site [active] 640131006744 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 640131006745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131006746 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131006747 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131006748 LysR substrate binding domain; Region: LysR_substrate; pfam03466 640131006749 dimerization interface [polypeptide binding]; other site 640131006750 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131006751 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131006752 ABC-ATPase subunit interface; other site 640131006753 dimer interface [polypeptide binding]; other site 640131006754 putative PBP binding regions; other site 640131006755 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 640131006756 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 640131006757 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 640131006758 catalytic residues [active] 640131006759 dimer interface [polypeptide binding]; other site 640131006760 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 640131006761 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131006762 Walker A/P-loop; other site 640131006763 ATP binding site [chemical binding]; other site 640131006764 Q-loop/lid; other site 640131006765 ABC transporter signature motif; other site 640131006766 Walker B; other site 640131006767 D-loop; other site 640131006768 H-loop/switch region; other site 640131006769 Type VI secretion lipoprotein; Region: T6SS-SciN; cl01405 640131006770 NlpC/P60 family; Region: NLPC_P60; pfam00877 640131006771 Uncharacterized conserved protein [Function unknown]; Region: COG0397 640131006772 hypothetical protein; Validated; Region: PRK00029 640131006773 hypothetical protein; Provisional; Region: PRK10183 640131006774 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 640131006775 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 640131006776 PEP synthetase regulatory protein; Provisional; Region: PRK05339 640131006777 phosphoenolpyruvate synthase; Validated; Region: PRK06464 640131006778 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 640131006779 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 640131006780 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 640131006781 putative inner membrane protein; Provisional; Region: PRK10983 640131006782 Domain of unknown function DUF20; Region: UPF0118; pfam01594 640131006783 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 640131006784 FAD binding domain; Region: FAD_binding_4; pfam01565 640131006785 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 640131006786 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 640131006787 CoenzymeA binding site [chemical binding]; other site 640131006788 subunit interaction site [polypeptide binding]; other site 640131006789 PHB binding site; other site 640131006790 hypothetical protein; Provisional; Region: PRK10457 640131006791 Domain of unknown function (DUF1852); Region: DUF1852; pfam08908 640131006792 methionine synthase; Provisional; Region: PRK01207 640131006793 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 640131006794 substrate binding site [chemical binding]; other site 640131006795 THF binding site; other site 640131006796 zinc-binding site [ion binding]; other site 640131006797 multidrug resistance protein MdtH; Provisional; Region: PRK11646 640131006798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131006799 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 640131006800 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131006801 Walker A/P-loop; other site 640131006802 ATP binding site [chemical binding]; other site 640131006803 Q-loop/lid; other site 640131006804 ABC transporter signature motif; other site 640131006805 Walker B; other site 640131006806 D-loop; other site 640131006807 H-loop/switch region; other site 640131006808 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131006809 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131006810 ABC-ATPase subunit interface; other site 640131006811 dimer interface [polypeptide binding]; other site 640131006812 putative PBP binding regions; other site 640131006813 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 640131006814 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 640131006815 intersubunit interface [polypeptide binding]; other site 640131006816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131006817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131006818 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131006819 dimerization interface [polypeptide binding]; other site 640131006820 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 640131006821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131006822 NAD(P) binding site [chemical binding]; other site 640131006823 active site 640131006824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131006825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131006826 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 640131006827 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131006828 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 640131006829 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 640131006830 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 640131006831 phosphate binding site [ion binding]; other site 640131006832 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 640131006833 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 640131006834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 640131006835 active site 640131006836 DNA binding site [nucleotide binding] 640131006837 Int/Topo IB signature motif; other site 640131006838 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 640131006839 Protein of unknown function (DUF4060); Region: DUF4060; pfam13269 640131006840 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 640131006841 RecT family; Region: RecT; pfam03837 640131006842 exonuclease VIII; Reviewed; Region: PRK09709 640131006843 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 640131006844 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 640131006845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131006846 non-specific DNA binding site [nucleotide binding]; other site 640131006847 salt bridge; other site 640131006848 sequence-specific DNA binding site [nucleotide binding]; other site 640131006849 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 640131006850 transcriptional repressor DicA; Reviewed; Region: PRK09706 640131006851 Helix-turn-helix; Region: HTH_3; pfam01381 640131006852 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 640131006853 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 640131006854 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 640131006855 primosomal protein DnaI; Provisional; Region: PRK02854 640131006856 putative replication protein; Provisional; Region: PRK12377 640131006857 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131006858 ATP binding site [chemical binding]; other site 640131006859 Walker A motif; other site 640131006860 Walker B motif; other site 640131006861 arginine finger; other site 640131006862 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 640131006863 Methyltransferase domain; Region: Methyltransf_25; pfam13649 640131006864 Protein of unknown function (DUF551); Region: DUF551; pfam04448 640131006865 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 640131006866 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 640131006867 Antitermination protein; Region: Antiterm; pfam03589 640131006868 Antitermination protein; Region: Antiterm; pfam03589 640131006869 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 640131006870 Protein of unknown function (DUF754); Region: DUF754; pfam05449 640131006871 Predicted chitinase [General function prediction only]; Region: COG3179 640131006872 catalytic residue [active] 640131006873 Protein of unknown function (DUF2560); Region: DUF2560; cl10280 640131006874 Terminase small subunit; Region: Terminase_2; pfam03592 640131006875 Phage terminase large subunit; Region: Terminase_3; cl12054 640131006876 Terminase-like family; Region: Terminase_6; pfam03237 640131006877 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 640131006878 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 640131006879 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 640131006880 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 640131006881 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 640131006882 Bacterial Ig-like domain 2; Region: BID_2; smart00635 640131006883 conjugal transfer protein TrbH; Provisional; Region: PRK13883 640131006884 Phage-related minor tail protein [Function unknown]; Region: COG5281 640131006885 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 640131006886 Domain of unknown function (DUF1833); Region: DUF1833; pfam08875 640131006887 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 640131006888 multiple promoter invertase; Provisional; Region: mpi; PRK13413 640131006889 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 640131006890 catalytic residues [active] 640131006891 catalytic nucleophile [active] 640131006892 Presynaptic Site I dimer interface [polypeptide binding]; other site 640131006893 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 640131006894 Synaptic Flat tetramer interface [polypeptide binding]; other site 640131006895 Synaptic Site I dimer interface [polypeptide binding]; other site 640131006896 DNA binding site [nucleotide binding] 640131006897 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 640131006898 DNA-binding interface [nucleotide binding]; DNA binding site 640131006899 LysE type translocator; Region: LysE; cl00565 640131006900 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 640131006901 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131006902 putative metal binding site [ion binding]; other site 640131006903 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 640131006904 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 640131006905 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131006906 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131006907 metal binding site [ion binding]; metal-binding site 640131006908 active site 640131006909 I-site; other site 640131006910 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 640131006911 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 640131006912 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 640131006913 putative ABC transporter; Region: ycf24; CHL00085 640131006914 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 640131006915 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 640131006916 Walker A/P-loop; other site 640131006917 ATP binding site [chemical binding]; other site 640131006918 Q-loop/lid; other site 640131006919 ABC transporter signature motif; other site 640131006920 Walker B; other site 640131006921 D-loop; other site 640131006922 H-loop/switch region; other site 640131006923 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 640131006924 FeS assembly protein SufD; Region: sufD; TIGR01981 640131006925 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 640131006926 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 640131006927 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131006928 catalytic residue [active] 640131006929 cysteine desufuration protein SufE; Provisional; Region: PRK09296 640131006930 L,D-transpeptidase; Provisional; Region: PRK10190 640131006931 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131006932 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 640131006933 murein lipoprotein; Provisional; Region: PRK15396 640131006934 pyruvate kinase; Provisional; Region: PRK09206 640131006935 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 640131006936 domain interfaces; other site 640131006937 active site 640131006938 hypothetical protein; Provisional; Region: PRK10292 640131006939 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 640131006940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131006941 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 640131006942 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 640131006943 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 640131006944 active site 640131006945 Fe binding site [ion binding]; other site 640131006946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131006947 D-galactonate transporter; Region: 2A0114; TIGR00893 640131006948 putative substrate translocation pore; other site 640131006949 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 640131006950 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 640131006951 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 640131006952 shikimate binding site; other site 640131006953 NAD(P) binding site [chemical binding]; other site 640131006954 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 640131006955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 640131006956 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 640131006957 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131006958 Walker A/P-loop; other site 640131006959 ATP binding site [chemical binding]; other site 640131006960 Q-loop/lid; other site 640131006961 ABC transporter signature motif; other site 640131006962 Walker B; other site 640131006963 D-loop; other site 640131006964 H-loop/switch region; other site 640131006965 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 640131006966 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131006967 ABC-ATPase subunit interface; other site 640131006968 dimer interface [polypeptide binding]; other site 640131006969 putative PBP binding regions; other site 640131006970 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 640131006971 putative ligand binding residues [chemical binding]; other site 640131006972 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 640131006973 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 640131006974 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131006975 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131006976 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 640131006977 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 640131006978 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 640131006979 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 640131006980 putative active site [active] 640131006981 Fe(II) binding site [ion binding]; other site 640131006982 putative dimer interface [polypeptide binding]; other site 640131006983 putative tetramer interface [polypeptide binding]; other site 640131006984 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 640131006985 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 640131006986 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 640131006987 acetaldehyde dehydrogenase; Validated; Region: PRK08300 640131006988 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 640131006989 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 640131006990 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 640131006991 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 640131006992 active site 640131006993 catalytic residues [active] 640131006994 metal binding site [ion binding]; metal-binding site 640131006995 DmpG-like communication domain; Region: DmpG_comm; pfam07836 640131006996 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 640131006997 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 640131006998 Member of the Rhodanese Homology Domain superfamily, repeat 1. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 1st repeat which does not contain the putative...; Region: 4RHOD_Repeat_1; cd01532 640131006999 active site residue [active] 640131007000 Member of the Rhodanese Homology Domain superfamily, repeat 2. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 2nd repeat which does contain the putative catalytic...; Region: 4RHOD_Repeat_2; cd01533 640131007001 active site residue [active] 640131007002 Member of the Rhodanese Homology Domain superfamily, repeat 3. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 3rd repeat which does not contain the putative...; Region: 4RHOD_Repeat_3; cd01534 640131007003 active site residue [active] 640131007004 Member of the Rhodanese Homology Domain superfamily, repeat 4. This CD includes putative rhodanese-related sulfurtransferases which contain 4 copies of the Rhodanese Homology Domain. This CD aligns the 4th repeat which, in general, contains the putative...; Region: 4RHOD_Repeat_4; cd01535 640131007005 active site residue [active] 640131007006 Predicted metal-dependent enzyme of the double-stranded beta helix superfamily [General function prediction only]; Region: COG5553 640131007007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007009 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131007010 dimerization interface [polypeptide binding]; other site 640131007011 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 640131007012 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 640131007013 dimer interface [polypeptide binding]; other site 640131007014 active site 640131007015 non-prolyl cis peptide bond; other site 640131007016 insertion regions; other site 640131007017 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 640131007018 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 640131007019 active site 640131007020 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 640131007021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131007022 membrane-bound complex binding site; other site 640131007023 hinge residues; other site 640131007024 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 640131007025 NMT1/THI5 like; Region: NMT1; pfam09084 640131007026 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131007027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007028 dimer interface [polypeptide binding]; other site 640131007029 conserved gate region; other site 640131007030 putative PBP binding loops; other site 640131007031 ABC-ATPase subunit interface; other site 640131007032 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 640131007033 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131007034 Walker A/P-loop; other site 640131007035 ATP binding site [chemical binding]; other site 640131007036 Q-loop/lid; other site 640131007037 ABC transporter signature motif; other site 640131007038 Walker B; other site 640131007039 D-loop; other site 640131007040 H-loop/switch region; other site 640131007041 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 640131007042 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131007043 N-terminal plug; other site 640131007044 ligand-binding site [chemical binding]; other site 640131007045 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 640131007046 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131007047 Walker A/P-loop; other site 640131007048 ATP binding site [chemical binding]; other site 640131007049 Q-loop/lid; other site 640131007050 ABC transporter signature motif; other site 640131007051 Walker B; other site 640131007052 D-loop; other site 640131007053 H-loop/switch region; other site 640131007054 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131007055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131007056 ABC-ATPase subunit interface; other site 640131007057 dimer interface [polypeptide binding]; other site 640131007058 putative PBP binding regions; other site 640131007059 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131007060 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131007061 ABC-ATPase subunit interface; other site 640131007062 dimer interface [polypeptide binding]; other site 640131007063 putative PBP binding regions; other site 640131007064 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 640131007065 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 640131007066 siderophore binding site; other site 640131007067 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 640131007068 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131007069 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 640131007070 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131007071 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131007072 substrate binding pocket [chemical binding]; other site 640131007073 membrane-bound complex binding site; other site 640131007074 hinge residues; other site 640131007075 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131007076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007077 dimer interface [polypeptide binding]; other site 640131007078 conserved gate region; other site 640131007079 putative PBP binding loops; other site 640131007080 ABC-ATPase subunit interface; other site 640131007081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131007082 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131007083 Walker A/P-loop; other site 640131007084 ATP binding site [chemical binding]; other site 640131007085 Q-loop/lid; other site 640131007086 ABC transporter signature motif; other site 640131007087 Walker B; other site 640131007088 D-loop; other site 640131007089 H-loop/switch region; other site 640131007090 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 640131007091 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 640131007092 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131007093 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 640131007094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131007095 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131007096 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131007097 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 640131007098 metal binding site [ion binding]; metal-binding site 640131007099 putative dimer interface [polypeptide binding]; other site 640131007100 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 640131007101 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 640131007102 [4Fe-4S] binding site [ion binding]; other site 640131007103 molybdopterin cofactor binding site; other site 640131007104 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 640131007105 molybdopterin cofactor binding site; other site 640131007106 putative dehydrogenase; Provisional; Region: PRK10098 640131007107 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 640131007108 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 640131007109 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 640131007110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007111 dimer interface [polypeptide binding]; other site 640131007112 conserved gate region; other site 640131007113 ABC-ATPase subunit interface; other site 640131007114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007115 dimer interface [polypeptide binding]; other site 640131007116 conserved gate region; other site 640131007117 putative PBP binding loops; other site 640131007118 ABC-ATPase subunit interface; other site 640131007119 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 640131007120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131007121 Walker A/P-loop; other site 640131007122 ATP binding site [chemical binding]; other site 640131007123 Q-loop/lid; other site 640131007124 ABC transporter signature motif; other site 640131007125 Walker B; other site 640131007126 D-loop; other site 640131007127 H-loop/switch region; other site 640131007128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 640131007129 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131007130 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 640131007131 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 640131007132 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 640131007133 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 640131007134 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 640131007135 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 640131007136 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 640131007137 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 640131007138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131007139 Walker A/P-loop; other site 640131007140 ATP binding site [chemical binding]; other site 640131007141 Q-loop/lid; other site 640131007142 ABC transporter signature motif; other site 640131007143 Walker B; other site 640131007144 D-loop; other site 640131007145 H-loop/switch region; other site 640131007146 heme exporter protein CcmB; Region: ccmB; TIGR01190 640131007147 heme exporter protein CcmC; Region: ccmC; TIGR01191 640131007148 Heme exporter protein D (CcmD); Region: CcmD; cl11475 640131007149 CcmE; Region: CcmE; cl00994 640131007150 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 640131007151 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 640131007152 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 640131007153 catalytic residues [active] 640131007154 central insert; other site 640131007155 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 640131007156 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 640131007157 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 640131007158 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 640131007159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131007160 Coenzyme A binding pocket [chemical binding]; other site 640131007161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131007162 Coenzyme A binding pocket [chemical binding]; other site 640131007163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131007164 sequence-specific DNA binding site [nucleotide binding]; other site 640131007165 salt bridge; other site 640131007166 Cupin domain; Region: Cupin_2; pfam07883 640131007167 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 640131007168 B3/4 domain; Region: B3_4; pfam03483 640131007169 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 640131007170 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 640131007171 putative dimer interface [polypeptide binding]; other site 640131007172 catalytic triad [active] 640131007173 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 640131007174 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 640131007175 active site 640131007176 dimer interface [polypeptide binding]; other site 640131007177 non-prolyl cis peptide bond; other site 640131007178 insertion regions; other site 640131007179 acetoin reductase; Validated; Region: PRK08643 640131007180 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 640131007181 NAD binding site [chemical binding]; other site 640131007182 homotetramer interface [polypeptide binding]; other site 640131007183 homodimer interface [polypeptide binding]; other site 640131007184 active site 640131007185 substrate binding site [chemical binding]; other site 640131007186 acetolactate synthase; Reviewed; Region: PRK08617 640131007187 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131007188 PYR/PP interface [polypeptide binding]; other site 640131007189 dimer interface [polypeptide binding]; other site 640131007190 TPP binding site [chemical binding]; other site 640131007191 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131007192 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 640131007193 TPP-binding site [chemical binding]; other site 640131007194 dimer interface [polypeptide binding]; other site 640131007195 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 640131007196 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 640131007197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007198 The C-terminal substrate binding domain of LysR-type transcrptional regulator BudR, which is responsible for activation of the expression of the butanediol operon genes; contains the type 2 periplasmic binding fold; Region: PBP2_BudR; cd08451 640131007199 putative dimerization interface [polypeptide binding]; other site 640131007200 putative substrate binding pocket [chemical binding]; other site 640131007201 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 640131007202 d-3-hydroxybutyrate dehydrogenase (HBDH), classical (c) SDRs; Region: HBDH_SDR_c; cd08940 640131007203 NAD binding site [chemical binding]; other site 640131007204 homotetramer interface [polypeptide binding]; other site 640131007205 homodimer interface [polypeptide binding]; other site 640131007206 substrate binding site [chemical binding]; other site 640131007207 active site 640131007208 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 640131007209 3-hydroxybutyryl-CoA dehydrogenase; Region: PLN02545 640131007210 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 640131007211 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131007212 putative acyltransferase; Provisional; Region: PRK05790 640131007213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131007214 dimer interface [polypeptide binding]; other site 640131007215 active site 640131007216 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 640131007217 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 640131007218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007220 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 640131007221 putative dimerization interface [polypeptide binding]; other site 640131007222 Protein of unknown function (DUF535); Region: DUF535; cl01128 640131007223 Predicted transcriptional regulators [Transcription]; Region: COG1733 640131007224 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 640131007225 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 640131007226 active site 1 [active] 640131007227 dimer interface [polypeptide binding]; other site 640131007228 hexamer interface [polypeptide binding]; other site 640131007229 active site 2 [active] 640131007230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007231 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131007232 putative substrate translocation pore; other site 640131007233 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 640131007234 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 640131007235 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 640131007236 Chromate transporter; Region: Chromate_transp; pfam02417 640131007237 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 640131007238 FAD binding domain; Region: FAD_binding_4; pfam01565 640131007239 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131007240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007241 dimer interface [polypeptide binding]; other site 640131007242 conserved gate region; other site 640131007243 putative PBP binding loops; other site 640131007244 ABC-ATPase subunit interface; other site 640131007245 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 640131007246 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131007247 Walker A/P-loop; other site 640131007248 ATP binding site [chemical binding]; other site 640131007249 Q-loop/lid; other site 640131007250 ABC transporter signature motif; other site 640131007251 Walker B; other site 640131007252 D-loop; other site 640131007253 H-loop/switch region; other site 640131007254 NMT1/THI5 like; Region: NMT1; pfam09084 640131007255 Creatinine amidohydrolase; Region: Creatininase; pfam02633 640131007256 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 640131007257 homotrimer interaction site [polypeptide binding]; other site 640131007258 putative active site [active] 640131007259 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 640131007260 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 640131007261 active site 640131007262 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 640131007263 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 640131007264 FMN-binding pocket [chemical binding]; other site 640131007265 flavin binding motif; other site 640131007266 phosphate binding motif [ion binding]; other site 640131007267 beta-alpha-beta structure motif; other site 640131007268 NAD binding pocket [chemical binding]; other site 640131007269 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131007270 catalytic loop [active] 640131007271 iron binding site [ion binding]; other site 640131007272 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007273 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007274 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131007275 dimerization interface [polypeptide binding]; other site 640131007276 NMT1/THI5 like; Region: NMT1; pfam09084 640131007277 amidohydrolase; Provisional; Region: PRK12393 640131007278 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 640131007279 active site 640131007280 putative substrate binding pocket [chemical binding]; other site 640131007281 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 640131007282 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 640131007283 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 640131007284 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 640131007285 Predicted dehydrogenase [General function prediction only]; Region: COG0579 640131007286 hydroxyglutarate oxidase; Provisional; Region: PRK11728 640131007287 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 640131007288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 640131007289 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131007290 Domain of unknown function (DUF1937); Region: DUF1937; pfam09152 640131007291 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 640131007292 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 640131007293 Proteobacterial glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK_like_proteobact; cd07794 640131007294 N- and C-terminal domain interface [polypeptide binding]; other site 640131007295 active site 640131007296 MgATP binding site [chemical binding]; other site 640131007297 catalytic site [active] 640131007298 metal binding site [ion binding]; metal-binding site 640131007299 putative homotetramer interface [polypeptide binding]; other site 640131007300 putative homodimer interface [polypeptide binding]; other site 640131007301 putative glycerol binding site [chemical binding]; other site 640131007302 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131007303 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131007304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131007305 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 640131007306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007308 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 640131007309 putative effector binding pocket; other site 640131007310 putative dimerization interface [polypeptide binding]; other site 640131007311 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 640131007312 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 640131007313 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 640131007314 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 640131007315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131007316 NAD(P) binding site [chemical binding]; other site 640131007317 active site 640131007318 putative transporter; Provisional; Region: PRK12382 640131007319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007320 putative substrate translocation pore; other site 640131007321 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 640131007322 Uncharacterized conserved protein [Function unknown]; Region: COG4925 640131007323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007324 transcriptional regulator; Provisional; Region: PRK10632 640131007325 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131007326 putative effector binding pocket; other site 640131007327 putative dimerization interface [polypeptide binding]; other site 640131007328 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 640131007329 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 640131007330 putative NAD(P) binding site [chemical binding]; other site 640131007331 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007332 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007333 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 640131007334 putative effector binding pocket; other site 640131007335 putative dimerization interface [polypeptide binding]; other site 640131007336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007337 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131007338 putative substrate translocation pore; other site 640131007339 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 640131007340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131007341 dimerization interface [polypeptide binding]; other site 640131007342 DNA binding residues [nucleotide binding] 640131007343 DinB family; Region: DinB; cl17821 640131007344 DinB superfamily; Region: DinB_2; pfam12867 640131007345 Domain of unknown function (DUF3315); Region: DUF3315; cl02275 640131007346 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 640131007347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131007348 Walker A/P-loop; other site 640131007349 ATP binding site [chemical binding]; other site 640131007350 Q-loop/lid; other site 640131007351 ABC transporter signature motif; other site 640131007352 Walker B; other site 640131007353 D-loop; other site 640131007354 H-loop/switch region; other site 640131007355 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 640131007356 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 640131007357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131007358 Walker A/P-loop; other site 640131007359 ATP binding site [chemical binding]; other site 640131007360 Q-loop/lid; other site 640131007361 ABC transporter signature motif; other site 640131007362 Walker B; other site 640131007363 D-loop; other site 640131007364 H-loop/switch region; other site 640131007365 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131007366 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 640131007367 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131007368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007369 dimer interface [polypeptide binding]; other site 640131007370 conserved gate region; other site 640131007371 putative PBP binding loops; other site 640131007372 ABC-ATPase subunit interface; other site 640131007373 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131007374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007375 dimer interface [polypeptide binding]; other site 640131007376 conserved gate region; other site 640131007377 putative PBP binding loops; other site 640131007378 ABC-ATPase subunit interface; other site 640131007379 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131007380 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 640131007381 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 640131007382 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 640131007383 Walker A/P-loop; other site 640131007384 ATP binding site [chemical binding]; other site 640131007385 Q-loop/lid; other site 640131007386 ABC transporter signature motif; other site 640131007387 Walker B; other site 640131007388 D-loop; other site 640131007389 H-loop/switch region; other site 640131007390 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131007391 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 640131007392 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 640131007393 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 640131007394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007395 dimer interface [polypeptide binding]; other site 640131007396 conserved gate region; other site 640131007397 putative PBP binding loops; other site 640131007398 ABC-ATPase subunit interface; other site 640131007399 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 640131007400 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 640131007401 active site 640131007402 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 640131007403 Chloramphenicol acetyltransferase; Region: CAT; cl02008 640131007404 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241 640131007405 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131007406 putative metal binding site [ion binding]; other site 640131007407 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131007408 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131007409 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131007410 LysE type translocator; Region: LysE; cl00565 640131007411 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 640131007412 active site clefts [active] 640131007413 zinc binding site [ion binding]; other site 640131007414 dimer interface [polypeptide binding]; other site 640131007415 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 640131007416 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 640131007417 putative NAD(P) binding site [chemical binding]; other site 640131007418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 640131007419 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 640131007420 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 640131007421 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131007423 dimerization interface [polypeptide binding]; other site 640131007424 Cupin; Region: Cupin_6; pfam12852 640131007425 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131007426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131007427 short chain dehydrogenase; Provisional; Region: PRK06180 640131007428 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 640131007429 NADP binding site [chemical binding]; other site 640131007430 active site 640131007431 steroid binding site; other site 640131007432 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 640131007433 multidrug efflux protein; Reviewed; Region: PRK01766 640131007434 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 640131007435 cation binding site [ion binding]; other site 640131007436 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 640131007437 Lumazine binding domain; Region: Lum_binding; pfam00677 640131007438 Lumazine binding domain; Region: Lum_binding; pfam00677 640131007439 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 640131007440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131007441 S-adenosylmethionine binding site [chemical binding]; other site 640131007442 putative transporter; Provisional; Region: PRK11043 640131007443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007444 putative substrate translocation pore; other site 640131007445 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 640131007446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131007448 dimerization interface [polypeptide binding]; other site 640131007449 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 640131007450 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131007451 DNA binding site [nucleotide binding] 640131007452 domain linker motif; other site 640131007453 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 640131007454 dimerization interface [polypeptide binding]; other site 640131007455 ligand binding site [chemical binding]; other site 640131007456 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131007457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007458 putative substrate translocation pore; other site 640131007459 superoxide dismutase; Provisional; Region: PRK10543 640131007460 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 640131007461 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 640131007462 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 640131007463 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131007464 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 640131007465 NlpC/P60 family; Region: NLPC_P60; pfam00877 640131007466 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 640131007467 putative GSH binding site [chemical binding]; other site 640131007468 catalytic residues [active] 640131007469 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 640131007470 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 640131007471 dimer interface [polypeptide binding]; other site 640131007472 catalytic site [active] 640131007473 putative active site [active] 640131007474 putative substrate binding site [chemical binding]; other site 640131007475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131007476 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 640131007477 dimer interface [polypeptide binding]; other site 640131007478 active site 640131007479 metal binding site [ion binding]; metal-binding site 640131007480 glutathione binding site [chemical binding]; other site 640131007481 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 640131007482 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 640131007483 FMN binding site [chemical binding]; other site 640131007484 active site 640131007485 substrate binding site [chemical binding]; other site 640131007486 catalytic residue [active] 640131007487 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131007488 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131007489 Predicted Fe-S protein [General function prediction only]; Region: COG3313 640131007490 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131007491 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131007492 active site 640131007493 catalytic tetrad [active] 640131007494 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 640131007495 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 640131007496 E-class dimer interface [polypeptide binding]; other site 640131007497 P-class dimer interface [polypeptide binding]; other site 640131007498 active site 640131007499 Cu2+ binding site [ion binding]; other site 640131007500 Zn2+ binding site [ion binding]; other site 640131007501 Fusaric acid resistance protein family; Region: FUSC; pfam04632 640131007502 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 640131007503 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 640131007504 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131007505 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131007506 Protein of unknown function (DUF1656); Region: DUF1656; pfam07869 640131007507 transcriptional regulator SlyA; Provisional; Region: PRK03573 640131007508 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 640131007509 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131007510 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131007511 metal binding site [ion binding]; metal-binding site 640131007512 active site 640131007513 I-site; other site 640131007514 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 640131007515 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 640131007516 lysozyme inhibitor; Provisional; Region: PRK11372 640131007517 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 640131007518 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 640131007519 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 640131007520 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 640131007521 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 640131007522 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 640131007523 active site 640131007524 HIGH motif; other site 640131007525 dimer interface [polypeptide binding]; other site 640131007526 KMSKS motif; other site 640131007527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131007528 RNA binding surface [nucleotide binding]; other site 640131007529 pyridoxamine kinase; Validated; Region: PRK05756 640131007530 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 640131007531 dimer interface [polypeptide binding]; other site 640131007532 pyridoxal binding site [chemical binding]; other site 640131007533 ATP binding site [chemical binding]; other site 640131007534 glutathionine S-transferase; Provisional; Region: PRK10542 640131007535 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 640131007536 C-terminal domain interface [polypeptide binding]; other site 640131007537 GSH binding site (G-site) [chemical binding]; other site 640131007538 dimer interface [polypeptide binding]; other site 640131007539 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 640131007540 N-terminal domain interface [polypeptide binding]; other site 640131007541 dimer interface [polypeptide binding]; other site 640131007542 substrate binding pocket (H-site) [chemical binding]; other site 640131007543 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 640131007544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007545 putative substrate translocation pore; other site 640131007546 POT family; Region: PTR2; pfam00854 640131007547 endonuclease III; Provisional; Region: PRK10702 640131007548 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 640131007549 minor groove reading motif; other site 640131007550 helix-hairpin-helix signature motif; other site 640131007551 substrate binding pocket [chemical binding]; other site 640131007552 active site 640131007553 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 640131007554 electron transport complex RsxE subunit; Provisional; Region: PRK12405 640131007555 electron transport complex protein RnfG; Validated; Region: PRK01908 640131007556 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 640131007557 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 640131007558 SLBB domain; Region: SLBB; pfam10531 640131007559 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131007560 electron transport complex protein RnfB; Provisional; Region: PRK05113 640131007561 Putative Fe-S cluster; Region: FeS; pfam04060 640131007562 4Fe-4S binding domain; Region: Fer4; cl02805 640131007563 electron transport complex protein RsxA; Provisional; Region: PRK05151 640131007564 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 640131007565 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 640131007566 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 640131007567 beta-galactosidase; Region: BGL; TIGR03356 640131007568 putative oxidoreductase; Provisional; Region: PRK11579 640131007569 LabA_like proteins; Region: LabA_like; cd06167 640131007570 putative metal binding site [ion binding]; other site 640131007571 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131007572 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 640131007573 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 640131007574 active site 640131007575 purine riboside binding site [chemical binding]; other site 640131007576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007577 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131007578 putative substrate translocation pore; other site 640131007579 Predicted transcriptional regulators [Transcription]; Region: COG1733 640131007580 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 640131007581 cytochrome b561; Provisional; Region: PRK11513 640131007582 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 640131007583 putative metal binding site [ion binding]; other site 640131007584 putative homodimer interface [polypeptide binding]; other site 640131007585 putative homotetramer interface [polypeptide binding]; other site 640131007586 putative homodimer-homodimer interface [polypeptide binding]; other site 640131007587 putative allosteric switch controlling residues; other site 640131007588 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 640131007589 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 640131007590 substrate binding site [chemical binding]; other site 640131007591 catalytic Zn binding site [ion binding]; other site 640131007592 NAD binding site [chemical binding]; other site 640131007593 structural Zn binding site [ion binding]; other site 640131007594 dimer interface [polypeptide binding]; other site 640131007595 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 640131007596 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 640131007597 Trp docking motif [polypeptide binding]; other site 640131007598 putative active site [active] 640131007599 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 640131007600 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007601 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131007602 dimerization interface [polypeptide binding]; other site 640131007603 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 640131007604 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 640131007605 heterodimer interface [polypeptide binding]; other site 640131007606 active site 640131007607 Protocatechuate 3,4-dioxygenase (3,4-PCD) , beta subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_beta; cd03464 640131007608 heterodimer interface [polypeptide binding]; other site 640131007609 multimer interface [polypeptide binding]; other site 640131007610 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 640131007611 active site 640131007612 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 640131007613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 640131007614 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 640131007615 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 640131007616 substrate binding pocket [chemical binding]; other site 640131007617 catalytic triad [active] 640131007618 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 640131007619 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 640131007620 catalytic Zn binding site [ion binding]; other site 640131007621 NAD binding site [chemical binding]; other site 640131007622 structural Zn binding site [ion binding]; other site 640131007623 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 640131007624 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 640131007625 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 640131007626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131007627 Coenzyme A binding pocket [chemical binding]; other site 640131007628 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 640131007629 putative trimer interface [polypeptide binding]; other site 640131007630 putative CoA binding site [chemical binding]; other site 640131007631 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 640131007632 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 640131007633 gating phenylalanine in ion channel; other site 640131007634 tellurite resistance protein TehB; Provisional; Region: PRK11207 640131007635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131007636 S-adenosylmethionine binding site [chemical binding]; other site 640131007637 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 640131007638 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 640131007639 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 640131007640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131007641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131007642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131007643 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 640131007644 benzoate transporter; Region: benE; TIGR00843 640131007645 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131007646 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131007647 non-specific DNA binding site [nucleotide binding]; other site 640131007648 salt bridge; other site 640131007649 sequence-specific DNA binding site [nucleotide binding]; other site 640131007650 Cupin domain; Region: Cupin_2; pfam07883 640131007651 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 640131007652 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 640131007653 Peptidase family U32; Region: Peptidase_U32; pfam01136 640131007654 Collagenase; Region: DUF3656; pfam12392 640131007655 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 640131007656 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 640131007657 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 640131007658 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 640131007659 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 640131007660 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 640131007661 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131007662 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131007663 DNA-binding site [nucleotide binding]; DNA binding site 640131007664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131007665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131007666 homodimer interface [polypeptide binding]; other site 640131007667 catalytic residue [active] 640131007668 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 640131007669 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 640131007670 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 640131007671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131007672 Walker A/P-loop; other site 640131007673 ATP binding site [chemical binding]; other site 640131007674 Q-loop/lid; other site 640131007675 ABC transporter signature motif; other site 640131007676 Walker B; other site 640131007677 D-loop; other site 640131007678 H-loop/switch region; other site 640131007679 TOBE domain; Region: TOBE_2; pfam08402 640131007680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007681 dimer interface [polypeptide binding]; other site 640131007682 conserved gate region; other site 640131007683 putative PBP binding loops; other site 640131007684 ABC-ATPase subunit interface; other site 640131007685 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131007686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 640131007687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007688 putative PBP binding loops; other site 640131007689 dimer interface [polypeptide binding]; other site 640131007690 ABC-ATPase subunit interface; other site 640131007691 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 640131007692 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 640131007693 tetrameric interface [polypeptide binding]; other site 640131007694 NAD binding site [chemical binding]; other site 640131007695 catalytic residues [active] 640131007696 substrate binding site [chemical binding]; other site 640131007697 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 640131007698 PGAP1-like protein; Region: PGAP1; pfam07819 640131007699 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 640131007700 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 640131007701 Salicylaldehyde dehydrogenase, DoxF-like; Region: ALDH_SaliADH; cd07105 640131007702 NAD(P) binding site [chemical binding]; other site 640131007703 catalytic residues [active] 640131007704 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131007705 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 640131007706 peptide binding site [polypeptide binding]; other site 640131007707 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 640131007708 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 640131007709 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 640131007710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131007711 Coenzyme A binding pocket [chemical binding]; other site 640131007712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131007713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131007714 sequence-specific DNA binding site [nucleotide binding]; other site 640131007715 salt bridge; other site 640131007716 Cupin domain; Region: Cupin_2; pfam07883 640131007717 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 640131007718 Prostaglandin dehydrogenases; Region: PGDH; cd05288 640131007719 NAD(P) binding site [chemical binding]; other site 640131007720 substrate binding site [chemical binding]; other site 640131007721 dimer interface [polypeptide binding]; other site 640131007722 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 640131007723 active site 640131007724 tetramer interface [polypeptide binding]; other site 640131007725 hypothetical protein; Provisional; Region: PRK09981 640131007726 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 640131007727 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131007728 N-terminal plug; other site 640131007729 ligand-binding site [chemical binding]; other site 640131007730 Uncharacterized conserved protein [Function unknown]; Region: COG3391 640131007731 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 640131007732 L-asparagine permease; Provisional; Region: PRK15049 640131007733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007735 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 640131007736 putative effector binding pocket; other site 640131007737 putative dimerization interface [polypeptide binding]; other site 640131007738 diaminopimelate epimerase; Provisional; Region: PRK13577 640131007739 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 640131007740 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 640131007741 Methyltransferase domain; Region: Methyltransf_31; pfam13847 640131007742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131007743 S-adenosylmethionine binding site [chemical binding]; other site 640131007744 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 640131007745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 640131007746 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131007747 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 640131007748 metal binding site [ion binding]; metal-binding site 640131007749 dimer interface [polypeptide binding]; other site 640131007750 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 640131007751 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 640131007752 active site 640131007753 non-prolyl cis peptide bond; other site 640131007754 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131007755 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131007756 substrate binding pocket [chemical binding]; other site 640131007757 membrane-bound complex binding site; other site 640131007758 hinge residues; other site 640131007759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131007760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131007761 Coenzyme A binding pocket [chemical binding]; other site 640131007762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007763 dimer interface [polypeptide binding]; other site 640131007764 conserved gate region; other site 640131007765 putative PBP binding loops; other site 640131007766 ABC-ATPase subunit interface; other site 640131007767 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131007768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131007769 Walker A/P-loop; other site 640131007770 ATP binding site [chemical binding]; other site 640131007771 Q-loop/lid; other site 640131007772 ABC transporter signature motif; other site 640131007773 Walker B; other site 640131007774 D-loop; other site 640131007775 H-loop/switch region; other site 640131007776 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131007777 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131007778 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131007779 substrate binding pocket [chemical binding]; other site 640131007780 membrane-bound complex binding site; other site 640131007781 hinge residues; other site 640131007782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007783 D-galactonate transporter; Region: 2A0114; TIGR00893 640131007784 putative substrate translocation pore; other site 640131007785 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 640131007786 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 640131007787 active site pocket [active] 640131007788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131007789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131007790 DNA binding site [nucleotide binding] 640131007791 domain linker motif; other site 640131007792 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 640131007793 putative dimerization interface [polypeptide binding]; other site 640131007794 putative ligand binding site [chemical binding]; other site 640131007795 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 640131007796 C-terminal domain interface [polypeptide binding]; other site 640131007797 GSH binding site (G-site) [chemical binding]; other site 640131007798 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 640131007799 dimer interface [polypeptide binding]; other site 640131007800 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 640131007801 dimer interface [polypeptide binding]; other site 640131007802 N-terminal domain interface [polypeptide binding]; other site 640131007803 substrate binding pocket (H-site) [chemical binding]; other site 640131007804 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 640131007805 active site 1 [active] 640131007806 dimer interface [polypeptide binding]; other site 640131007807 hexamer interface [polypeptide binding]; other site 640131007808 active site 2 [active] 640131007809 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 640131007810 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131007811 trimer interface; other site 640131007812 sugar binding site [chemical binding]; other site 640131007813 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 640131007814 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 640131007815 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 640131007816 transcriptional activator RhaR; Provisional; Region: PRK13501 640131007817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131007818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131007819 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 640131007820 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 640131007821 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 640131007822 Walker A/P-loop; other site 640131007823 ATP binding site [chemical binding]; other site 640131007824 Q-loop/lid; other site 640131007825 ABC transporter signature motif; other site 640131007826 Walker B; other site 640131007827 D-loop; other site 640131007828 H-loop/switch region; other site 640131007829 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 640131007830 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 640131007831 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 640131007832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007833 dimer interface [polypeptide binding]; other site 640131007834 conserved gate region; other site 640131007835 putative PBP binding loops; other site 640131007836 ABC-ATPase subunit interface; other site 640131007837 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 640131007838 TetR family transcriptional regulator; Provisional; Region: PRK14996 640131007839 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131007840 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 640131007841 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007842 putative substrate translocation pore; other site 640131007843 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 640131007844 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131007845 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131007846 Muconate Lactonizing Enzyme (MLE), an homooctameric enzyme, catalyses the conversion of cis,cis-muconate (CCM) to muconolactone (ML) in the catechol branch of the beta-ketoadipate pathway. This pathway is used in soil microbes to breakdown lignin-derived...; Region: MLE; cd03318 640131007847 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 640131007848 octamer interface [polypeptide binding]; other site 640131007849 active site 640131007850 muconolactone delta-isomerase; Region: muco_delta; TIGR03221 640131007851 catechol 1,2-dioxygenase, proteobacterial; Region: catechol_proteo; TIGR02439 640131007852 Catechol 1,2 dioxygenase (1,2-CTD) catalyzes an intradiol cleavage reaction of catechol to form cis,cis-muconate. 1,2-CTDs is homodimers with one catalytic non-heme ferric ion per monomer. They belong to the aromatic dioxygenase family, a family of...; Region: 1,2-CTD; cd03460 640131007853 dimer interface [polypeptide binding]; other site 640131007854 active site 640131007855 benzoate 1,2-dioxygenase, large subunit; Region: benzo_1_2_benA; TIGR03229 640131007856 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 640131007857 iron-sulfur cluster [ion binding]; other site 640131007858 [2Fe-2S] cluster binding site [ion binding]; other site 640131007859 C-terminal catalytic domain of the oxygenase alpha subunit of Pseudomonas resinovorans strain CA10 anthranilate 1,2-dioxygenase and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_AntDO-like; cd08879 640131007860 putative alpha subunit interface [polypeptide binding]; other site 640131007861 putative active site [active] 640131007862 putative substrate binding site [chemical binding]; other site 640131007863 Fe binding site [ion binding]; other site 640131007864 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 640131007865 inter-subunit interface; other site 640131007866 anthranilate dioxygenase reductase; Provisional; Region: antC; PRK11872 640131007867 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131007868 catalytic loop [active] 640131007869 iron binding site [ion binding]; other site 640131007870 Benzoate dioxygenase reductase (BenDO) FAD/NAD binding domain. Oxygenases oxidize hydrocarbons using dioxygen as the oxidant. As a Class I bacterial dioxygenases, benzoate dioxygenase like proteins combine an [2Fe-2S] cluster containing N-terminal...; Region: BenDO_FAD_NAD; cd06209 640131007871 FAD binding pocket [chemical binding]; other site 640131007872 FAD binding motif [chemical binding]; other site 640131007873 phosphate binding motif [ion binding]; other site 640131007874 beta-alpha-beta structure motif; other site 640131007875 NAD binding pocket [chemical binding]; other site 640131007876 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 640131007877 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase (DHB DH)-like, classical (c) SDR; Region: DHB_DH-like_SDR_c; cd08937 640131007878 putative NAD(P) binding site [chemical binding]; other site 640131007879 active site 640131007880 aromatic amino acid exporter; Provisional; Region: PRK11689 640131007881 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131007882 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131007883 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131007884 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131007885 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 640131007886 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 640131007887 molybdopterin cofactor binding site; other site 640131007888 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 640131007889 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 640131007890 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 640131007891 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 640131007892 CcdB protein; Region: CcdB; cl03380 640131007893 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 640131007894 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131007895 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 640131007896 active site 640131007897 metal binding site [ion binding]; metal-binding site 640131007898 MFS transport protein AraJ; Provisional; Region: PRK10091 640131007899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131007900 putative substrate translocation pore; other site 640131007901 CMD domain protein, Avi_7170 family; Region: CMD_Avi_7170; TIGR04029 640131007902 alkylhydroperoxidase domain protein, Avi_7169 family; Region: perox_Avi_7169; TIGR04030 640131007903 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 640131007904 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 640131007905 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 640131007906 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 640131007907 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131007908 Walker A/P-loop; other site 640131007909 ATP binding site [chemical binding]; other site 640131007910 Q-loop/lid; other site 640131007911 ABC transporter signature motif; other site 640131007912 Walker B; other site 640131007913 D-loop; other site 640131007914 H-loop/switch region; other site 640131007915 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131007916 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131007917 Walker A/P-loop; other site 640131007918 ATP binding site [chemical binding]; other site 640131007919 Q-loop/lid; other site 640131007920 ABC transporter signature motif; other site 640131007921 Walker B; other site 640131007922 D-loop; other site 640131007923 H-loop/switch region; other site 640131007924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131007925 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 640131007926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007927 ABC-ATPase subunit interface; other site 640131007928 putative PBP binding loops; other site 640131007929 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131007930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131007931 dimer interface [polypeptide binding]; other site 640131007932 conserved gate region; other site 640131007933 ABC-ATPase subunit interface; other site 640131007934 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131007935 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 640131007936 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 640131007937 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 640131007938 NAD binding site [chemical binding]; other site 640131007939 substrate binding site [chemical binding]; other site 640131007940 catalytic Zn binding site [ion binding]; other site 640131007941 tetramer interface [polypeptide binding]; other site 640131007942 structural Zn binding site [ion binding]; other site 640131007943 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 640131007944 dimer interface [polypeptide binding]; other site 640131007945 substrate binding site [chemical binding]; other site 640131007946 metal binding sites [ion binding]; metal-binding site 640131007947 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131007948 MarR family; Region: MarR_2; pfam12802 640131007949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131007950 Coenzyme A binding pocket [chemical binding]; other site 640131007951 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131007952 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 640131007953 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131007954 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 640131007955 malate dehydrogenase; Provisional; Region: PRK13529 640131007956 Malic enzyme, N-terminal domain; Region: malic; pfam00390 640131007957 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 640131007958 NAD(P) binding site [chemical binding]; other site 640131007959 30S ribosomal protein subunit S22 family; Region: Ribosomal_S22; cl11579 640131007960 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 640131007961 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131007962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131007963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131007964 putative effector binding pocket; other site 640131007965 dimerization interface [polypeptide binding]; other site 640131007966 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 640131007967 oxidoreductase; Provisional; Region: PRK06128 640131007968 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 640131007969 NAD binding site [chemical binding]; other site 640131007970 metal binding site [ion binding]; metal-binding site 640131007971 active site 640131007972 General stress protein [General function prediction only]; Region: GsiB; COG3729 640131007973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 640131007974 trehalose synthase; Region: treS_nterm; TIGR02456 640131007975 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 640131007976 active site 640131007977 catalytic site [active] 640131007978 short chain dehydrogenase; Provisional; Region: PRK07109 640131007979 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 640131007980 putative NAD(P) binding site [chemical binding]; other site 640131007981 active site 640131007982 Predicted membrane protein [Function unknown]; Region: COG2323 640131007983 hypothetical protein; Provisional; Region: PRK10053 640131007984 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 640131007985 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 640131007986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131007987 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131007988 substrate binding pocket [chemical binding]; other site 640131007989 membrane-bound complex binding site; other site 640131007990 hinge residues; other site 640131007991 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 640131007992 Cation efflux family; Region: Cation_efflux; pfam01545 640131007993 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 640131007994 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 640131007995 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 640131007996 putative molybdopterin cofactor binding site [chemical binding]; other site 640131007997 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 640131007998 putative molybdopterin cofactor binding site; other site 640131007999 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008001 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131008002 dimerization interface [polypeptide binding]; other site 640131008003 benzoate transport; Region: 2A0115; TIGR00895 640131008004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008005 putative substrate translocation pore; other site 640131008006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008007 putative substrate translocation pore; other site 640131008008 Predicted ATPase [General function prediction only]; Region: COG1485 640131008009 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 640131008010 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 640131008011 heme binding site [chemical binding]; other site 640131008012 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 640131008013 heme binding site [chemical binding]; other site 640131008014 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 640131008015 penicillin-binding protein 2; Provisional; Region: PRK10795 640131008016 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 640131008017 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 640131008018 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 640131008019 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 640131008020 catalytic triad [active] 640131008021 coenzyme PQQ biosynthesis probable peptidase PqqF; Region: PQQ_syn_pqqF; TIGR02110 640131008022 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 640131008023 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 640131008024 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 640131008025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131008026 FeS/SAM binding site; other site 640131008027 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 640131008028 pyrroloquinoline quinone biosynthesis protein PqqD; Provisional; Region: PRK02079 640131008029 pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157 640131008030 pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184 640131008031 coenzyme PQQ biosynthesis protein B; Region: PQQ_syn_pqqB; TIGR02108 640131008032 coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284 640131008033 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 640131008034 active site 640131008035 dimer interface [polypeptide binding]; other site 640131008036 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 640131008037 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 640131008038 osmolarity response regulator; Provisional; Region: ompR; PRK09468 640131008039 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131008040 active site 640131008041 phosphorylation site [posttranslational modification] 640131008042 intermolecular recognition site; other site 640131008043 dimerization interface [polypeptide binding]; other site 640131008044 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131008045 DNA binding site [nucleotide binding] 640131008046 HAMP domain; Region: HAMP; pfam00672 640131008047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131008048 dimer interface [polypeptide binding]; other site 640131008049 phosphorylation site [posttranslational modification] 640131008050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131008051 ATP binding site [chemical binding]; other site 640131008052 Mg2+ binding site [ion binding]; other site 640131008053 G-X-G motif; other site 640131008054 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 640131008055 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 640131008056 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 640131008057 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 640131008058 catalytic residues [active] 640131008059 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008060 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008061 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131008062 dimerization interface [polypeptide binding]; other site 640131008063 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 640131008064 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131008065 catalytic residue [active] 640131008066 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06931 640131008067 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131008068 inhibitor-cofactor binding pocket; inhibition site 640131008069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131008070 catalytic residue [active] 640131008071 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 640131008072 NMT1/THI5 like; Region: NMT1; pfam09084 640131008073 membrane-bound complex binding site; other site 640131008074 hinge residues; other site 640131008075 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131008076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131008077 dimer interface [polypeptide binding]; other site 640131008078 conserved gate region; other site 640131008079 ABC-ATPase subunit interface; other site 640131008080 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 640131008081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131008082 Walker A/P-loop; other site 640131008083 ATP binding site [chemical binding]; other site 640131008084 Q-loop/lid; other site 640131008085 ABC transporter signature motif; other site 640131008086 Walker B; other site 640131008087 D-loop; other site 640131008088 H-loop/switch region; other site 640131008089 Putative transcription activator [Transcription]; Region: TenA; COG0819 640131008090 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 640131008091 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 640131008092 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131008093 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131008094 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131008095 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 640131008096 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 640131008097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131008098 DNA binding site [nucleotide binding] 640131008099 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 640131008100 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131008101 PAS domain; Region: PAS_9; pfam13426 640131008102 putative active site [active] 640131008103 heme pocket [chemical binding]; other site 640131008104 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131008105 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131008106 metal binding site [ion binding]; metal-binding site 640131008107 active site 640131008108 I-site; other site 640131008109 guanine deaminase; Provisional; Region: PRK09228 640131008110 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 640131008111 active site 640131008112 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily; solute-binding domain; Region: SLC-NCS1sbd_u1; cd11555 640131008113 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 640131008114 Na binding site [ion binding]; other site 640131008115 putative substrate binding site [chemical binding]; other site 640131008116 Transcriptional regulators [Transcription]; Region: FadR; COG2186 640131008117 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131008118 DNA-binding site [nucleotide binding]; DNA binding site 640131008119 FCD domain; Region: FCD; pfam07729 640131008120 Hydantoin racemase [Amino acid transport and metabolism]; Region: COG4126 640131008121 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 640131008122 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 640131008123 active site 640131008124 catalytic site [active] 640131008125 tetramer interface [polypeptide binding]; other site 640131008126 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 640131008127 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131008128 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131008129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008130 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 640131008131 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 640131008132 catalytic triad [active] 640131008133 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131008134 Helix-turn-helix domain; Region: HTH_18; pfam12833 640131008135 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 640131008136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008138 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131008139 putative effector binding pocket; other site 640131008140 dimerization interface [polypeptide binding]; other site 640131008141 Protein of unknown function, DUF606; Region: DUF606; pfam04657 640131008142 Protein of unknown function, DUF606; Region: DUF606; pfam04657 640131008143 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 640131008144 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131008145 trimer interface; other site 640131008146 sugar binding site [chemical binding]; other site 640131008147 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131008148 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 640131008149 active site turn [active] 640131008150 phosphorylation site [posttranslational modification] 640131008151 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131008152 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 640131008153 HPr interaction site; other site 640131008154 glycerol kinase (GK) interaction site [polypeptide binding]; other site 640131008155 active site 640131008156 phosphorylation site [posttranslational modification] 640131008157 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 640131008158 beta-galactosidase; Region: BGL; TIGR03356 640131008159 transcriptional antiterminator BglG; Provisional; Region: PRK09772 640131008160 CAT RNA binding domain; Region: CAT_RBD; smart01061 640131008161 PRD domain; Region: PRD; pfam00874 640131008162 PRD domain; Region: PRD; pfam00874 640131008163 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008164 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008165 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131008166 dimerization interface [polypeptide binding]; other site 640131008167 glutathionine S-transferase; Provisional; Region: PRK10542 640131008168 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 640131008169 C-terminal domain interface [polypeptide binding]; other site 640131008170 GSH binding site (G-site) [chemical binding]; other site 640131008171 dimer interface [polypeptide binding]; other site 640131008172 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 640131008173 dimer interface [polypeptide binding]; other site 640131008174 N-terminal domain interface [polypeptide binding]; other site 640131008175 substrate binding pocket (H-site) [chemical binding]; other site 640131008176 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 640131008177 active site 640131008178 P-loop; other site 640131008179 phosphorylation site [posttranslational modification] 640131008180 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06333 640131008181 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 640131008182 dimer interface [polypeptide binding]; other site 640131008183 active site 640131008184 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 640131008185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008186 putative substrate translocation pore; other site 640131008187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008188 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 640131008189 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131008190 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131008191 Predicted transcriptional regulators [Transcription]; Region: COG1733 640131008192 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 640131008193 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 640131008194 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 640131008195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131008196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131008197 Coenzyme A binding pocket [chemical binding]; other site 640131008198 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 640131008199 amidase; Provisional; Region: PRK09201 640131008200 Amidase; Region: Amidase; pfam01425 640131008201 Protein of unknown function (DUF4089); Region: DUF4089; pfam13318 640131008202 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 640131008203 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 640131008204 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 640131008205 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131008206 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 640131008207 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131008208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131008209 substrate binding pocket [chemical binding]; other site 640131008210 membrane-bound complex binding site; other site 640131008211 hinge residues; other site 640131008212 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131008213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131008214 dimer interface [polypeptide binding]; other site 640131008215 conserved gate region; other site 640131008216 putative PBP binding loops; other site 640131008217 ABC-ATPase subunit interface; other site 640131008218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131008219 dimer interface [polypeptide binding]; other site 640131008220 conserved gate region; other site 640131008221 putative PBP binding loops; other site 640131008222 ABC-ATPase subunit interface; other site 640131008223 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131008224 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131008225 Walker A/P-loop; other site 640131008226 ATP binding site [chemical binding]; other site 640131008227 Q-loop/lid; other site 640131008228 ABC transporter signature motif; other site 640131008229 Walker B; other site 640131008230 D-loop; other site 640131008231 H-loop/switch region; other site 640131008232 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 640131008233 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131008234 catalytic residue [active] 640131008235 allantoate amidohydrolase; Reviewed; Region: PRK09290 640131008236 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 640131008237 active site 640131008238 metal binding site [ion binding]; metal-binding site 640131008239 dimer interface [polypeptide binding]; other site 640131008240 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 640131008241 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 640131008242 FMN binding site [chemical binding]; other site 640131008243 substrate binding site [chemical binding]; other site 640131008244 putative catalytic residue [active] 640131008245 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008246 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008247 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131008248 putative effector binding pocket; other site 640131008249 putative dimerization interface [polypeptide binding]; other site 640131008250 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 640131008251 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 640131008252 active site 640131008253 FMN binding site [chemical binding]; other site 640131008254 substrate binding site [chemical binding]; other site 640131008255 homotetramer interface [polypeptide binding]; other site 640131008256 catalytic residue [active] 640131008257 hypothetical protein; Provisional; Region: PRK09897 640131008258 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 640131008259 putative sialic acid transporter; Region: 2A0112; TIGR00891 640131008260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008261 putative substrate translocation pore; other site 640131008262 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 640131008263 EamA-like transporter family; Region: EamA; pfam00892 640131008264 EamA-like transporter family; Region: EamA; pfam00892 640131008265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131008266 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131008267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 640131008268 Protein of unknown function (DUF796); Region: DUF796; cl01226 640131008269 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 640131008270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 640131008271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131008272 oxalate/formate antiporter; Region: oxa_formateAnti; TIGR04259 640131008273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008274 putative substrate translocation pore; other site 640131008275 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 640131008276 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 640131008277 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131008278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 640131008279 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131008280 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 640131008281 Walker A/P-loop; other site 640131008282 ATP binding site [chemical binding]; other site 640131008283 Q-loop/lid; other site 640131008284 ABC transporter signature motif; other site 640131008285 Walker B; other site 640131008286 D-loop; other site 640131008287 H-loop/switch region; other site 640131008288 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 640131008289 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 640131008290 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 640131008291 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 640131008292 urea carboxylase; Region: urea_carbox; TIGR02712 640131008293 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 640131008294 ATP-grasp domain; Region: ATP-grasp_4; cl17255 640131008295 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 640131008296 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 640131008297 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 640131008298 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 640131008299 carboxyltransferase (CT) interaction site; other site 640131008300 biotinylation site [posttranslational modification]; other site 640131008301 allophanate hydrolase; Provisional; Region: PRK08186 640131008302 Amidase; Region: Amidase; cl11426 640131008303 classical (c) SDRs; Region: SDR_c; cd05233 640131008304 NAD(P) binding site [chemical binding]; other site 640131008305 active site 640131008306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008308 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131008309 putative effector binding pocket; other site 640131008310 dimerization interface [polypeptide binding]; other site 640131008311 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131008312 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131008313 DNA binding site [nucleotide binding] 640131008314 domain linker motif; other site 640131008315 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 640131008316 putative dimerization interface [polypeptide binding]; other site 640131008317 putative ligand binding site [chemical binding]; other site 640131008318 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131008319 active site 640131008320 phosphorylation site [posttranslational modification] 640131008321 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 640131008322 active site 640131008323 P-loop; other site 640131008324 phosphorylation site [posttranslational modification] 640131008325 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 640131008326 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 640131008327 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 640131008328 substrate binding site [chemical binding]; other site 640131008329 hexamer interface [polypeptide binding]; other site 640131008330 metal binding site [ion binding]; metal-binding site 640131008331 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131008332 active site 640131008333 phosphorylation site [posttranslational modification] 640131008334 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 640131008335 active site 640131008336 P-loop; other site 640131008337 phosphorylation site [posttranslational modification] 640131008338 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 640131008339 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 640131008340 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 640131008341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131008342 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131008343 DNA binding residues [nucleotide binding] 640131008344 dimerization interface [polypeptide binding]; other site 640131008345 Fimbrial protein; Region: Fimbrial; cl01416 640131008346 Fimbrial protein; Region: Fimbrial; pfam00419 640131008347 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131008348 PapC N-terminal domain; Region: PapC_N; pfam13954 640131008349 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131008350 PapC C-terminal domain; Region: PapC_C; pfam13953 640131008351 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 640131008352 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131008353 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131008354 Fimbrial protein; Region: Fimbrial; cl01416 640131008355 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 640131008356 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 640131008357 ligand binding site [chemical binding]; other site 640131008358 flexible hinge region; other site 640131008359 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 640131008360 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 640131008361 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131008362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008363 putative substrate translocation pore; other site 640131008364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008366 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131008367 putative effector binding pocket; other site 640131008368 dimerization interface [polypeptide binding]; other site 640131008369 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008370 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008371 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131008372 putative effector binding pocket; other site 640131008373 dimerization interface [polypeptide binding]; other site 640131008374 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 640131008375 TolA C-terminal; Region: TolA; pfam06519 640131008376 TolA protein; Region: tolA_full; TIGR02794 640131008377 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 640131008378 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 640131008379 metal binding site [ion binding]; metal-binding site 640131008380 dimer interface [polypeptide binding]; other site 640131008381 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 640131008382 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 640131008383 active site 640131008384 substrate binding pocket [chemical binding]; other site 640131008385 homodimer interaction site [polypeptide binding]; other site 640131008386 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131008387 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131008388 TM-ABC transporter signature motif; other site 640131008389 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 640131008390 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131008391 Walker A/P-loop; other site 640131008392 ATP binding site [chemical binding]; other site 640131008393 Q-loop/lid; other site 640131008394 ABC transporter signature motif; other site 640131008395 Walker B; other site 640131008396 D-loop; other site 640131008397 H-loop/switch region; other site 640131008398 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131008399 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131008400 DNA binding site [nucleotide binding] 640131008401 domain linker motif; other site 640131008402 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_11; cd06293 640131008403 putative dimerization interface [polypeptide binding]; other site 640131008404 putative ligand binding site [chemical binding]; other site 640131008405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 640131008406 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 640131008407 ligand binding site [chemical binding]; other site 640131008408 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131008409 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 640131008410 substrate binding site [chemical binding]; other site 640131008411 dimer interface [polypeptide binding]; other site 640131008412 ATP binding site [chemical binding]; other site 640131008413 BtpA family; Region: BtpA; cl00440 640131008414 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 640131008415 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131008416 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 640131008417 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131008418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 640131008419 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 640131008420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131008421 dimer interface [polypeptide binding]; other site 640131008422 conserved gate region; other site 640131008423 ABC-ATPase subunit interface; other site 640131008424 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 640131008425 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131008426 Walker A/P-loop; other site 640131008427 ATP binding site [chemical binding]; other site 640131008428 Q-loop/lid; other site 640131008429 ABC transporter signature motif; other site 640131008430 Walker B; other site 640131008431 D-loop; other site 640131008432 H-loop/switch region; other site 640131008433 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 640131008434 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131008435 Walker A/P-loop; other site 640131008436 ATP binding site [chemical binding]; other site 640131008437 Q-loop/lid; other site 640131008438 ABC transporter signature motif; other site 640131008439 Walker B; other site 640131008440 D-loop; other site 640131008441 H-loop/switch region; other site 640131008442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131008443 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 640131008444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008445 putative substrate translocation pore; other site 640131008446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008447 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 640131008448 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131008449 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131008450 MarR family; Region: MarR_2; cl17246 640131008451 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131008452 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 640131008453 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 640131008454 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 640131008455 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 640131008456 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 640131008457 conserved cys residue [active] 640131008458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008460 MltA-interacting protein MipA; Region: MipA; cl01504 640131008461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 640131008462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131008463 active site 640131008464 phosphorylation site [posttranslational modification] 640131008465 intermolecular recognition site; other site 640131008466 dimerization interface [polypeptide binding]; other site 640131008467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131008468 DNA binding site [nucleotide binding] 640131008469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 640131008470 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 640131008471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131008472 dimer interface [polypeptide binding]; other site 640131008473 phosphorylation site [posttranslational modification] 640131008474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131008475 ATP binding site [chemical binding]; other site 640131008476 Mg2+ binding site [ion binding]; other site 640131008477 G-X-G motif; other site 640131008478 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 640131008479 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131008480 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131008481 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 640131008482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131008483 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 640131008484 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 640131008485 heme-binding site [chemical binding]; other site 640131008486 amidase; Provisional; Region: PRK07235 640131008487 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 640131008488 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 640131008489 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 640131008490 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 640131008491 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 640131008492 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 640131008493 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 640131008494 Probable cobalt transporter subunit (CbtA); Region: CbtA; pfam09490 640131008495 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 640131008496 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 640131008497 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 640131008498 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 640131008499 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 640131008500 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008501 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008502 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 640131008503 putative dimerization interface [polypeptide binding]; other site 640131008504 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 640131008505 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 640131008506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131008507 DNA-binding site [nucleotide binding]; DNA binding site 640131008508 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 640131008509 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 640131008510 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131008511 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131008512 active site turn [active] 640131008513 phosphorylation site [posttranslational modification] 640131008514 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 640131008515 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 640131008516 NAD binding site [chemical binding]; other site 640131008517 sugar binding site [chemical binding]; other site 640131008518 divalent metal binding site [ion binding]; other site 640131008519 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131008520 dimer interface [polypeptide binding]; other site 640131008521 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 640131008522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008523 putative substrate translocation pore; other site 640131008524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131008526 active site 640131008527 phosphorylation site [posttranslational modification] 640131008528 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 640131008529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131008530 PAS domain; Region: PAS_9; pfam13426 640131008531 putative active site [active] 640131008532 heme pocket [chemical binding]; other site 640131008533 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131008534 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131008535 metal binding site [ion binding]; metal-binding site 640131008536 active site 640131008537 I-site; other site 640131008538 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131008539 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 640131008540 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 640131008541 active site 640131008542 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 640131008543 Beta-lactamase; Region: Beta-lactamase; pfam00144 640131008544 Protein of unknown function (DUF2975); Region: DUF2975; pfam11188 640131008545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131008546 non-specific DNA binding site [nucleotide binding]; other site 640131008547 salt bridge; other site 640131008548 sequence-specific DNA binding site [nucleotide binding]; other site 640131008549 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131008550 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131008551 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131008552 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131008553 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131008554 PapC N-terminal domain; Region: PapC_N; pfam13954 640131008555 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131008556 PapC C-terminal domain; Region: PapC_C; pfam13953 640131008557 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131008558 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 640131008559 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 640131008560 HipA N-terminal domain; Region: Couple_hipA; pfam13657 640131008561 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 640131008562 HipA-like N-terminal domain; Region: HipA_N; pfam07805 640131008563 HipA-like C-terminal domain; Region: HipA_C; pfam07804 640131008564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131008565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131008566 non-specific DNA binding site [nucleotide binding]; other site 640131008567 salt bridge; other site 640131008568 sequence-specific DNA binding site [nucleotide binding]; other site 640131008569 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 640131008570 active site 640131008571 homotetramer interface [polypeptide binding]; other site 640131008572 OHCU decarboxylase; Region: UraD_2; TIGR03180 640131008573 xanthine permease; Region: pbuX; TIGR03173 640131008574 hypothetical protein; Provisional; Region: PRK07236 640131008575 FAD binding domain; Region: FAD_binding_3; pfam01494 640131008576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008577 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 640131008578 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131008579 dimerization interface [polypeptide binding]; other site 640131008580 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 640131008581 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 640131008582 [2Fe-2S] cluster binding site [ion binding]; other site 640131008583 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 640131008584 hydrophobic ligand binding site; other site 640131008585 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 640131008586 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 640131008587 FMN-binding pocket [chemical binding]; other site 640131008588 flavin binding motif; other site 640131008589 phosphate binding motif [ion binding]; other site 640131008590 beta-alpha-beta structure motif; other site 640131008591 NAD binding pocket [chemical binding]; other site 640131008592 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131008593 catalytic loop [active] 640131008594 iron binding site [ion binding]; other site 640131008595 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 640131008596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008597 putative substrate translocation pore; other site 640131008598 Cupin; Region: Cupin_6; pfam12852 640131008599 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131008600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008602 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 640131008603 Cupin domain; Region: Cupin_2; cl17218 640131008604 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 640131008605 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 640131008606 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 640131008607 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 640131008608 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 640131008609 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 640131008610 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131008611 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 640131008612 Walker A/P-loop; other site 640131008613 ATP binding site [chemical binding]; other site 640131008614 Q-loop/lid; other site 640131008615 ABC transporter signature motif; other site 640131008616 Walker B; other site 640131008617 D-loop; other site 640131008618 H-loop/switch region; other site 640131008619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131008620 dimer interface [polypeptide binding]; other site 640131008621 conserved gate region; other site 640131008622 ABC-ATPase subunit interface; other site 640131008623 Nitronate monooxygenase; Region: NMO; pfam03060 640131008624 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 640131008625 FMN binding site [chemical binding]; other site 640131008626 substrate binding site [chemical binding]; other site 640131008627 putative catalytic residue [active] 640131008628 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008629 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008630 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131008631 dimerization interface [polypeptide binding]; other site 640131008632 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 640131008633 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131008634 active site 640131008635 major facilitator superfamily transporter; Provisional; Region: PRK05122 640131008636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008637 putative substrate translocation pore; other site 640131008638 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 640131008639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131008640 S-adenosylmethionine binding site [chemical binding]; other site 640131008641 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 640131008642 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 640131008643 Protein of unknown function (DUF796); Region: DUF796; cl01226 640131008644 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 640131008645 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131008646 Coenzyme A binding pocket [chemical binding]; other site 640131008647 altronate oxidoreductase; Provisional; Region: PRK03643 640131008648 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 640131008649 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 640131008650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131008651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131008652 Coenzyme A binding pocket [chemical binding]; other site 640131008653 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131008654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131008655 metal binding site [ion binding]; metal-binding site 640131008656 active site 640131008657 I-site; other site 640131008658 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 640131008659 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 640131008660 glutaminase; Provisional; Region: PRK00971 640131008661 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 640131008662 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 640131008663 NAD(P) binding site [chemical binding]; other site 640131008664 catalytic residues [active] 640131008665 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 640131008666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008667 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 640131008668 putative dimerization interface [polypeptide binding]; other site 640131008669 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 640131008670 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 640131008671 tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131008672 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 640131008673 NAD binding site [chemical binding]; other site 640131008674 dimer interface [polypeptide binding]; other site 640131008675 substrate binding site [chemical binding]; other site 640131008676 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131008677 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131008678 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131008679 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 640131008680 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 640131008681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 640131008682 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 640131008683 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 640131008684 active site 640131008685 NAD binding site [chemical binding]; other site 640131008686 metal binding site [ion binding]; metal-binding site 640131008687 dihydrodipicolinate synthase; Region: dapA; TIGR00674 640131008688 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 640131008689 inhibitor site; inhibition site 640131008690 active site 640131008691 dimer interface [polypeptide binding]; other site 640131008692 catalytic residue [active] 640131008693 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 640131008694 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 640131008695 Na binding site [ion binding]; other site 640131008696 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 640131008697 BNR repeat-like domain; Region: BNR_2; pfam13088 640131008698 Domain of unknown function (DUF386); Region: DUF386; cl01047 640131008699 short chain dehydrogenase; Provisional; Region: PRK07577 640131008700 classical (c) SDRs; Region: SDR_c; cd05233 640131008701 NAD(P) binding site [chemical binding]; other site 640131008702 active site 640131008703 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 640131008704 putative arabinose transporter; Provisional; Region: PRK03545 640131008705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008706 putative substrate translocation pore; other site 640131008707 inner membrane protein; Provisional; Region: PRK10995 640131008708 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 640131008709 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131008710 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 640131008711 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008713 MarB protein; Region: MarB; pfam13999 640131008714 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 640131008715 putative transporter; Provisional; Region: PRK10054 640131008716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008717 putative substrate translocation pore; other site 640131008718 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131008719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131008720 non-specific DNA binding site [nucleotide binding]; other site 640131008721 salt bridge; other site 640131008722 sequence-specific DNA binding site [nucleotide binding]; other site 640131008723 2TM domain; Region: 2TM; pfam13239 640131008724 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 640131008725 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 640131008726 Walker A/P-loop; other site 640131008727 ATP binding site [chemical binding]; other site 640131008728 Q-loop/lid; other site 640131008729 ABC transporter signature motif; other site 640131008730 Walker B; other site 640131008731 D-loop; other site 640131008732 H-loop/switch region; other site 640131008733 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 640131008734 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 640131008735 Walker A/P-loop; other site 640131008736 ATP binding site [chemical binding]; other site 640131008737 Q-loop/lid; other site 640131008738 ABC transporter signature motif; other site 640131008739 Walker B; other site 640131008740 D-loop; other site 640131008741 H-loop/switch region; other site 640131008742 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 640131008743 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 640131008744 TM-ABC transporter signature motif; other site 640131008745 HEAT repeats; Region: HEAT_2; pfam13646 640131008746 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 640131008747 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131008748 TM-ABC transporter signature motif; other site 640131008749 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 640131008750 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 640131008751 putative ligand binding site [chemical binding]; other site 640131008752 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 640131008753 substrate binding site [chemical binding]; other site 640131008754 THF binding site; other site 640131008755 zinc-binding site [ion binding]; other site 640131008756 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 640131008757 active site residue [active] 640131008758 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 640131008759 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 640131008760 conserved cys residue [active] 640131008761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008762 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008763 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131008764 Coenzyme A binding pocket [chemical binding]; other site 640131008765 lac repressor; Reviewed; Region: lacI; PRK09526 640131008766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131008767 DNA binding site [nucleotide binding] 640131008768 domain linker motif; other site 640131008769 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 640131008770 ligand binding site [chemical binding]; other site 640131008771 dimerization interface (open form) [polypeptide binding]; other site 640131008772 dimerization interface (closed form) [polypeptide binding]; other site 640131008773 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 640131008774 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 640131008775 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 640131008776 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 640131008777 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 640131008778 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 640131008779 Predicted ATPase [General function prediction only]; Region: COG4637 640131008780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131008781 Walker A/P-loop; other site 640131008782 ATP binding site [chemical binding]; other site 640131008783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131008784 ABC transporter signature motif; other site 640131008785 Walker B; other site 640131008786 D-loop; other site 640131008787 H-loop/switch region; other site 640131008788 beta-lactamase TEM; Provisional; Region: PRK15442 640131008789 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 640131008790 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131008791 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131008792 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131008793 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 640131008794 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 640131008795 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 640131008796 putative aldolase; Validated; Region: PRK08130 640131008797 active site 640131008798 intersubunit interface [polypeptide binding]; other site 640131008799 Zn2+ binding site [ion binding]; other site 640131008800 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 640131008801 putative transporter; Provisional; Region: PRK09821 640131008802 GntP family permease; Region: GntP_permease; pfam02447 640131008803 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 640131008804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131008805 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 640131008806 Sensors of blue-light using FAD; Region: BLUF; smart01034 640131008807 Ubiquinol-cytochrome C reductase complex 14kD subunit; Region: UCR_14kD; pfam02271 640131008808 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131008809 hypothetical protein; Validated; Region: PRK03657 640131008810 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 640131008811 alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins; Region: alpha-crystallin-Hsps_p23-like; cl00175 640131008812 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131008813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131008814 DNA binding residues [nucleotide binding] 640131008815 dimerization interface [polypeptide binding]; other site 640131008816 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 640131008817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131008818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008819 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131008820 putative effector binding pocket; other site 640131008821 dimerization interface [polypeptide binding]; other site 640131008822 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 640131008823 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 640131008824 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131008825 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131008826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008828 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_8; cd08477 640131008829 putative effector binding pocket; other site 640131008830 putative dimerization interface [polypeptide binding]; other site 640131008831 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 640131008832 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 640131008833 catalytic core [active] 640131008834 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008835 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 640131008836 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 640131008837 dimerization interface [polypeptide binding]; other site 640131008838 substrate binding pocket [chemical binding]; other site 640131008839 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 640131008840 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131008841 PYR/PP interface [polypeptide binding]; other site 640131008842 dimer interface [polypeptide binding]; other site 640131008843 TPP binding site [chemical binding]; other site 640131008844 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131008845 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 640131008846 TPP-binding site [chemical binding]; other site 640131008847 dimer interface [polypeptide binding]; other site 640131008848 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 640131008849 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 640131008850 putative active site [active] 640131008851 putative metal binding site [ion binding]; other site 640131008852 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 640131008853 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 640131008854 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 640131008855 active site 640131008856 Zn binding site [ion binding]; other site 640131008857 malonic semialdehyde reductase; Provisional; Region: PRK10538 640131008858 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 640131008859 putative NAD(P) binding site [chemical binding]; other site 640131008860 homodimer interface [polypeptide binding]; other site 640131008861 homotetramer interface [polypeptide binding]; other site 640131008862 active site 640131008863 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131008864 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131008865 DNA-binding site [nucleotide binding]; DNA binding site 640131008866 FCD domain; Region: FCD; pfam07729 640131008867 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131008868 Ligand Binding Site [chemical binding]; other site 640131008869 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 640131008870 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 640131008871 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 640131008872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008873 D-galactonate transporter; Region: 2A0114; TIGR00893 640131008874 putative substrate translocation pore; other site 640131008875 hypothetical protein; Provisional; Region: PRK02237 640131008876 hypothetical protein; Provisional; Region: PRK13659 640131008877 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 640131008878 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131008879 Coenzyme A binding pocket [chemical binding]; other site 640131008880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131008881 lipoprotein; Reviewed; Region: PRK02939 640131008882 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 640131008883 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 640131008884 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 640131008885 putative [Fe4-S4] binding site [ion binding]; other site 640131008886 putative molybdopterin cofactor binding site [chemical binding]; other site 640131008887 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 640131008888 putative molybdopterin cofactor binding site; other site 640131008889 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 640131008890 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 640131008891 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 640131008892 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 640131008893 Cl- selectivity filter; other site 640131008894 Cl- binding residues [ion binding]; other site 640131008895 pore gating glutamate residue; other site 640131008896 dimer interface [polypeptide binding]; other site 640131008897 putative dithiobiotin synthetase; Provisional; Region: PRK12374 640131008898 AAA domain; Region: AAA_26; pfam13500 640131008899 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 640131008900 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 640131008901 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131008902 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 640131008903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008904 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 640131008905 dimerization interface [polypeptide binding]; other site 640131008906 substrate binding pocket [chemical binding]; other site 640131008907 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131008908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008909 putative substrate translocation pore; other site 640131008910 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 640131008911 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 640131008912 active site 640131008913 Zn binding site [ion binding]; other site 640131008914 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 640131008915 CHASE4 domain; Region: CHASE4; pfam05228 640131008916 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131008917 metal binding site [ion binding]; metal-binding site 640131008918 active site 640131008919 I-site; other site 640131008920 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131008921 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 640131008922 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 640131008923 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 640131008924 Domain of unknown function DUF20; Region: UPF0118; pfam01594 640131008925 malonate decarboxylase, alpha subunit; Region: mdcA; TIGR01110 640131008926 Coenzyme A transferase; Region: CoA_trans; cl17247 640131008927 triphosphoribosyl-dephospho-CoA synthase; Validated; Region: PRK01237 640131008928 malonate decarboxylase acyl carrier protein; Region: malonate_delta; TIGR03130 640131008929 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189 640131008930 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; pfam06833 640131008931 he Auxin Efflux Carrier (AEC) Family; Region: 2a69; TIGR00946 640131008932 phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293 640131008933 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 640131008934 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 640131008935 malonate decarboxylase, epsilon subunit; Region: malonate_mdcH; TIGR03131 640131008936 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131008937 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008938 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131008939 dimerization interface [polypeptide binding]; other site 640131008940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131008941 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 640131008942 putative substrate translocation pore; other site 640131008943 malate:quinone oxidoreductase; Validated; Region: PRK05257 640131008944 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 640131008945 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 640131008946 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 640131008947 putative active site [active] 640131008948 sensory histidine kinase DcuS; Provisional; Region: PRK11086 640131008949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131008950 ATP binding site [chemical binding]; other site 640131008951 Mg2+ binding site [ion binding]; other site 640131008952 G-X-G motif; other site 640131008953 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 640131008954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131008955 active site 640131008956 phosphorylation site [posttranslational modification] 640131008957 intermolecular recognition site; other site 640131008958 dimerization interface [polypeptide binding]; other site 640131008959 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 640131008960 ApbE family; Region: ApbE; pfam02424 640131008961 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 640131008962 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 640131008963 putative active site [active] 640131008964 putative FMN binding site [chemical binding]; other site 640131008965 putative substrate binding site [chemical binding]; other site 640131008966 putative catalytic residue [active] 640131008967 FMN-binding domain; Region: FMN_bind; cl01081 640131008968 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 640131008969 L-aspartate oxidase; Provisional; Region: PRK06175 640131008970 Predicted oxidoreductase [General function prediction only]; Region: COG3573 640131008971 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 640131008972 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 640131008973 transmembrane helices; other site 640131008974 fumarate hydratase; Provisional; Region: PRK15389 640131008975 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 640131008976 Fumarase C-terminus; Region: Fumerase_C; pfam05683 640131008977 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 640131008978 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131008979 4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425 640131008980 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 640131008981 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 640131008982 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 640131008983 tetramer interface [polypeptide binding]; other site 640131008984 active site 640131008985 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 640131008986 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131008987 dimer interface [polypeptide binding]; other site 640131008988 active site 640131008989 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 640131008990 3-oxoacid CoA-transferase, A subunit; Region: pcaI_scoA_fam; TIGR02429 640131008991 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 640131008992 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131008993 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131008994 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 640131008995 Smr domain; Region: Smr; pfam01713 640131008996 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 640131008997 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131008998 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131008999 dimerization interface [polypeptide binding]; other site 640131009000 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 640131009001 amidohydrolase; Region: amidohydrolases; TIGR01891 640131009002 putative metal binding site [ion binding]; other site 640131009003 dimer interface [polypeptide binding]; other site 640131009004 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 640131009005 amidohydrolase; Region: amidohydrolases; TIGR01891 640131009006 putative metal binding site [ion binding]; other site 640131009007 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 640131009008 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 640131009009 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 640131009010 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 640131009011 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 640131009012 DNA binding site [nucleotide binding] 640131009013 active site 640131009014 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 640131009015 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 640131009016 ligand binding site [chemical binding]; other site 640131009017 flexible hinge region; other site 640131009018 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 640131009019 putative switch regulator; other site 640131009020 non-specific DNA interactions [nucleotide binding]; other site 640131009021 DNA binding site [nucleotide binding] 640131009022 sequence specific DNA binding site [nucleotide binding]; other site 640131009023 putative cAMP binding site [chemical binding]; other site 640131009024 universal stress protein UspE; Provisional; Region: PRK11175 640131009025 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131009026 Ligand Binding Site [chemical binding]; other site 640131009027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131009028 Ligand Binding Site [chemical binding]; other site 640131009029 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 640131009030 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 640131009031 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 640131009032 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 640131009033 ligand binding site [chemical binding]; other site 640131009034 homodimer interface [polypeptide binding]; other site 640131009035 NAD(P) binding site [chemical binding]; other site 640131009036 trimer interface B [polypeptide binding]; other site 640131009037 trimer interface A [polypeptide binding]; other site 640131009038 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 640131009039 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131009040 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131009041 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131009042 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 640131009043 Spore germination protein; Region: Spore_permease; cl17796 640131009044 dihydromonapterin reductase; Provisional; Region: PRK06483 640131009045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131009046 NAD(P) binding site [chemical binding]; other site 640131009047 active site 640131009048 GlpM protein; Region: GlpM; pfam06942 640131009049 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 640131009050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131009051 active site 640131009052 phosphorylation site [posttranslational modification] 640131009053 intermolecular recognition site; other site 640131009054 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131009055 DNA binding site [nucleotide binding] 640131009056 classical (c) SDRs; Region: SDR_c; cd05233 640131009057 NAD(P) binding site [chemical binding]; other site 640131009058 sensor protein RstB; Provisional; Region: PRK10604 640131009059 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131009060 dimerization interface [polypeptide binding]; other site 640131009061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131009062 dimer interface [polypeptide binding]; other site 640131009063 phosphorylation site [posttranslational modification] 640131009064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131009065 ATP binding site [chemical binding]; other site 640131009066 Mg2+ binding site [ion binding]; other site 640131009067 G-X-G motif; other site 640131009068 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 640131009069 fumarate hydratase; Reviewed; Region: fumC; PRK00485 640131009070 Class II fumarases; Region: Fumarase_classII; cd01362 640131009071 active site 640131009072 tetramer interface [polypeptide binding]; other site 640131009073 fumarate hydratase; Provisional; Region: PRK15389 640131009074 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 640131009075 Fumarase C-terminus; Region: Fumerase_C; pfam05683 640131009076 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 640131009077 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 640131009078 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 640131009079 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 640131009080 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 640131009081 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 640131009082 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131009083 DNA binding site [nucleotide binding] 640131009084 domain linker motif; other site 640131009085 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 640131009086 putative dimerization interface [polypeptide binding]; other site 640131009087 putative ligand binding site [chemical binding]; other site 640131009088 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 640131009089 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 640131009090 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131009091 active site turn [active] 640131009092 phosphorylation site [posttranslational modification] 640131009093 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 640131009094 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131009095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131009096 homodimer interface [polypeptide binding]; other site 640131009097 catalytic residue [active] 640131009098 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 640131009099 Uncharacterized bacterial subgroup of the Salmonella typhimurium Zn2+ transporter ZntB-like subfamily; Region: ZntB_u1; cd12834 640131009100 Cl binding site [ion binding]; other site 640131009101 oligomer interface [polypeptide binding]; other site 640131009102 YdfZ protein; Region: YdfZ; pfam14001 640131009103 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 640131009104 putative inner membrane protein; Provisional; Region: PRK11099 640131009105 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 640131009106 CPxP motif; other site 640131009107 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 640131009108 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 640131009109 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 640131009110 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 640131009111 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 640131009112 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 640131009113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 640131009114 NAD binding site [chemical binding]; other site 640131009115 catalytic residues [active] 640131009116 substrate binding site [chemical binding]; other site 640131009117 Uncharacterized conserved protein [Function unknown]; Region: COG1434 640131009118 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 640131009119 putative active site [active] 640131009120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131009121 metabolite-proton symporter; Region: 2A0106; TIGR00883 640131009122 putative substrate translocation pore; other site 640131009123 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 640131009124 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 640131009125 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 640131009126 putative active site [active] 640131009127 Zn binding site [ion binding]; other site 640131009128 succinylarginine dihydrolase; Provisional; Region: PRK13281 640131009129 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 640131009130 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 640131009131 NAD(P) binding site [chemical binding]; other site 640131009132 catalytic residues [active] 640131009133 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 640131009134 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 640131009135 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 640131009136 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131009137 inhibitor-cofactor binding pocket; inhibition site 640131009138 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131009139 catalytic residue [active] 640131009140 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 640131009141 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 640131009142 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 640131009143 NAD(P) binding site [chemical binding]; other site 640131009144 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 640131009145 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 640131009146 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 640131009147 putative acyltransferase; Provisional; Region: PRK05790 640131009148 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131009149 dimer interface [polypeptide binding]; other site 640131009150 active site 640131009151 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 640131009152 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 640131009153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 640131009154 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131009155 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131009156 active site 640131009157 catalytic tetrad [active] 640131009158 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131009159 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131009160 putative substrate translocation pore; other site 640131009161 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131009162 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131009163 active site 640131009164 catalytic tetrad [active] 640131009165 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009166 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009167 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 640131009168 putative effector binding pocket; other site 640131009169 putative dimerization interface [polypeptide binding]; other site 640131009170 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131009171 MarR family; Region: MarR_2; pfam12802 640131009172 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131009173 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131009174 putative substrate translocation pore; other site 640131009175 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 640131009176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131009177 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131009178 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 640131009179 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 640131009180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 640131009181 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 640131009182 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131009183 ATP binding site [chemical binding]; other site 640131009184 putative Mg++ binding site [ion binding]; other site 640131009185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131009186 nucleotide binding region [chemical binding]; other site 640131009187 ATP-binding site [chemical binding]; other site 640131009188 Helicase associated domain (HA2); Region: HA2; pfam04408 640131009189 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 640131009190 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 640131009191 azoreductase; Reviewed; Region: PRK00170 640131009192 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 640131009193 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 640131009194 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131009195 non-specific DNA binding site [nucleotide binding]; other site 640131009196 salt bridge; other site 640131009197 sequence-specific DNA binding site [nucleotide binding]; other site 640131009198 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 640131009199 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 640131009200 putative trimer interface [polypeptide binding]; other site 640131009201 putative metal binding site [ion binding]; other site 640131009202 PaaX-like protein; Region: PaaX; pfam07848 640131009203 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 640131009204 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 640131009205 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 640131009206 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 640131009207 active site 640131009208 AMP binding site [chemical binding]; other site 640131009209 homodimer interface [polypeptide binding]; other site 640131009210 acyl-activating enzyme (AAE) consensus motif; other site 640131009211 CoA binding site [chemical binding]; other site 640131009212 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 640131009213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131009214 dimer interface [polypeptide binding]; other site 640131009215 active site 640131009216 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 640131009217 CoenzymeA binding site [chemical binding]; other site 640131009218 subunit interaction site [polypeptide binding]; other site 640131009219 PHB binding site; other site 640131009220 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 640131009221 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 640131009222 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131009223 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131009224 enoyl-CoA hydratase; Provisional; Region: PRK08140 640131009225 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 640131009226 substrate binding site [chemical binding]; other site 640131009227 oxyanion hole (OAH) forming residues; other site 640131009228 trimer interface [polypeptide binding]; other site 640131009229 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 640131009230 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 640131009231 substrate binding site [chemical binding]; other site 640131009232 oxyanion hole (OAH) forming residues; other site 640131009233 trimer interface [polypeptide binding]; other site 640131009234 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 640131009235 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 640131009236 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 640131009237 FAD binding pocket [chemical binding]; other site 640131009238 FAD binding motif [chemical binding]; other site 640131009239 phosphate binding motif [ion binding]; other site 640131009240 beta-alpha-beta structure motif; other site 640131009241 NAD(p) ribose binding residues [chemical binding]; other site 640131009242 NAD binding pocket [chemical binding]; other site 640131009243 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 640131009244 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131009245 catalytic loop [active] 640131009246 iron binding site [ion binding]; other site 640131009247 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 640131009248 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 640131009249 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 640131009250 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 640131009251 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 640131009252 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 640131009253 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 640131009254 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 640131009255 substrate binding site [chemical binding]; other site 640131009256 dimer interface [polypeptide binding]; other site 640131009257 NADP binding site [chemical binding]; other site 640131009258 catalytic residues [active] 640131009259 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 640131009260 substrate binding site [chemical binding]; other site 640131009261 tyramine oxidase; Provisional; Region: tynA; PRK14696 640131009262 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 640131009263 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 640131009264 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 640131009265 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 640131009266 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 640131009267 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 640131009268 NADP binding site [chemical binding]; other site 640131009269 dimer interface [polypeptide binding]; other site 640131009270 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 640131009271 acetylornithine deacetylase; Provisional; Region: PRK07522 640131009272 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 640131009273 metal binding site [ion binding]; metal-binding site 640131009274 putative dimer interface [polypeptide binding]; other site 640131009275 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 640131009276 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 640131009277 homotrimer interaction site [polypeptide binding]; other site 640131009278 putative active site [active] 640131009279 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 640131009280 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131009281 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009283 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 640131009284 putative substrate binding pocket [chemical binding]; other site 640131009285 dimerization interface [polypeptide binding]; other site 640131009286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009287 dimer interface [polypeptide binding]; other site 640131009288 conserved gate region; other site 640131009289 putative PBP binding loops; other site 640131009290 ABC-ATPase subunit interface; other site 640131009291 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131009292 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131009293 Walker A/P-loop; other site 640131009294 ATP binding site [chemical binding]; other site 640131009295 Q-loop/lid; other site 640131009296 ABC transporter signature motif; other site 640131009297 Walker B; other site 640131009298 D-loop; other site 640131009299 H-loop/switch region; other site 640131009300 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 640131009301 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131009302 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131009303 substrate binding pocket [chemical binding]; other site 640131009304 membrane-bound complex binding site; other site 640131009305 hinge residues; other site 640131009306 hypothetical protein; Provisional; Region: PRK07490 640131009307 intersubunit interface [polypeptide binding]; other site 640131009308 active site 640131009309 Zn2+ binding site [ion binding]; other site 640131009310 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 640131009311 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 640131009312 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 640131009313 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 640131009314 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 640131009315 NAD(P) binding site [chemical binding]; other site 640131009316 catalytic residues [active] 640131009317 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 640131009318 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131009319 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 640131009320 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 640131009321 hypothetical protein; Provisional; Region: PRK10695 640131009322 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 640131009323 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 640131009324 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 640131009325 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 640131009326 putative ligand binding site [chemical binding]; other site 640131009327 putative NAD binding site [chemical binding]; other site 640131009328 catalytic site [active] 640131009329 META domain; Region: META; cl01245 640131009330 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 640131009331 Domain of unknown function (DUF333); Region: DUF333; pfam03891 640131009332 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 640131009333 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 640131009334 dimer interface [polypeptide binding]; other site 640131009335 PYR/PP interface [polypeptide binding]; other site 640131009336 TPP binding site [chemical binding]; other site 640131009337 substrate binding site [chemical binding]; other site 640131009338 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 640131009339 Domain of unknown function; Region: EKR; pfam10371 640131009340 4Fe-4S binding domain; Region: Fer4_6; pfam12837 640131009341 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131009342 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 640131009343 TPP-binding site [chemical binding]; other site 640131009344 dimer interface [polypeptide binding]; other site 640131009345 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 640131009346 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 640131009347 trimer interface [polypeptide binding]; other site 640131009348 eyelet of channel; other site 640131009349 KTSC domain; Region: KTSC; pfam13619 640131009350 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131009351 Ligand Binding Site [chemical binding]; other site 640131009352 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 640131009353 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 640131009354 Ligand Binding Site [chemical binding]; other site 640131009355 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 640131009356 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 640131009357 ATP binding site [chemical binding]; other site 640131009358 Mg++ binding site [ion binding]; other site 640131009359 motif III; other site 640131009360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131009361 nucleotide binding region [chemical binding]; other site 640131009362 ATP-binding site [chemical binding]; other site 640131009363 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 640131009364 putative RNA binding site [nucleotide binding]; other site 640131009365 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 640131009366 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 640131009367 Cl binding site [ion binding]; other site 640131009368 oligomer interface [polypeptide binding]; other site 640131009369 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131009370 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131009371 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131009372 putative oxidoreductase; Provisional; Region: PRK11579 640131009373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131009374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131009375 aromatic amino acid transporter; Provisional; Region: PRK10238 640131009376 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 640131009377 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 640131009378 putative DNA binding site [nucleotide binding]; other site 640131009379 putative Zn2+ binding site [ion binding]; other site 640131009380 AsnC family; Region: AsnC_trans_reg; pfam01037 640131009381 Uncharacterized conserved protein [Function unknown]; Region: COG1284 640131009382 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 640131009383 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 640131009384 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 640131009385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131009386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131009387 homodimer interface [polypeptide binding]; other site 640131009388 catalytic residue [active] 640131009389 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 640131009390 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 640131009391 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 640131009392 Walker A/P-loop; other site 640131009393 ATP binding site [chemical binding]; other site 640131009394 Q-loop/lid; other site 640131009395 ABC transporter signature motif; other site 640131009396 Walker B; other site 640131009397 D-loop; other site 640131009398 H-loop/switch region; other site 640131009399 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131009400 NIL domain; Region: NIL; pfam09383 640131009401 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 640131009402 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 640131009403 transaminase; Reviewed; Region: PRK08068 640131009404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131009405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131009406 homodimer interface [polypeptide binding]; other site 640131009407 catalytic residue [active] 640131009408 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 640131009409 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 640131009410 putative NAD(P) binding site [chemical binding]; other site 640131009411 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131009412 NmrA-like family; Region: NmrA; pfam05368 640131009413 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 640131009414 NADP binding site [chemical binding]; other site 640131009415 active site 640131009416 regulatory binding site [polypeptide binding]; other site 640131009417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 640131009418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009420 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 640131009421 putative substrate binding pocket [chemical binding]; other site 640131009422 putative dimerization interface [polypeptide binding]; other site 640131009423 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009424 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009425 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131009426 putative effector binding pocket; other site 640131009427 putative dimerization interface [polypeptide binding]; other site 640131009428 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 640131009429 NmrA-like family; Region: NmrA; pfam05368 640131009430 NAD(P) binding site [chemical binding]; other site 640131009431 active site lysine 640131009432 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131009433 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 640131009434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131009435 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131009436 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 640131009437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131009438 NAD(P) binding site [chemical binding]; other site 640131009439 active site 640131009440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131009441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131009442 oxidoreductase; Provisional; Region: PRK12742 640131009443 classical (c) SDRs; Region: SDR_c; cd05233 640131009444 NAD(P) binding site [chemical binding]; other site 640131009445 active site 640131009446 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 640131009447 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 640131009448 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 640131009449 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 640131009450 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 640131009451 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 640131009452 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 640131009453 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 640131009454 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 640131009455 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 640131009456 PAAR motif; Region: PAAR_motif; pfam05488 640131009457 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 640131009458 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 640131009459 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 640131009460 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 640131009461 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 640131009462 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 640131009463 Protein of unknown function (DUF3304); Region: DUF3304; pfam11745 640131009464 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 640131009465 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 640131009466 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 640131009467 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 640131009468 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 640131009469 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 640131009470 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 640131009471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131009472 Walker A motif; other site 640131009473 ATP binding site [chemical binding]; other site 640131009474 Walker B motif; other site 640131009475 arginine finger; other site 640131009476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131009477 Walker A motif; other site 640131009478 ATP binding site [chemical binding]; other site 640131009479 Walker B motif; other site 640131009480 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 640131009481 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 640131009482 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 640131009483 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 640131009484 ligand binding site [chemical binding]; other site 640131009485 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 640131009486 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 640131009487 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 640131009488 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 640131009489 Protein of unknown function (DUF877); Region: DUF877; pfam05943 640131009490 Protein of unknown function (DUF770); Region: DUF770; pfam05591 640131009491 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 640131009492 intracellular protease, PfpI family; Region: PfpI; TIGR01382 640131009493 conserved cys residue [active] 640131009494 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 640131009495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131009496 NAD(P) binding site [chemical binding]; other site 640131009497 active site 640131009498 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009499 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009500 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131009501 putative effector binding pocket; other site 640131009502 putative dimerization interface [polypeptide binding]; other site 640131009503 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 640131009504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 640131009505 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 640131009506 anti sigma factor interaction site; other site 640131009507 regulatory phosphorylation site [posttranslational modification]; other site 640131009508 Response regulator receiver domain; Region: Response_reg; pfam00072 640131009509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131009510 active site 640131009511 phosphorylation site [posttranslational modification] 640131009512 intermolecular recognition site; other site 640131009513 dimerization interface [polypeptide binding]; other site 640131009514 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 640131009515 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 640131009516 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 640131009517 heme-binding site [chemical binding]; other site 640131009518 PAS fold; Region: PAS_7; pfam12860 640131009519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131009520 putative active site [active] 640131009521 heme pocket [chemical binding]; other site 640131009522 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 640131009523 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131009524 dimer interface [polypeptide binding]; other site 640131009525 phosphorylation site [posttranslational modification] 640131009526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131009527 ATP binding site [chemical binding]; other site 640131009528 Mg2+ binding site [ion binding]; other site 640131009529 G-X-G motif; other site 640131009530 Response regulator receiver domain; Region: Response_reg; pfam00072 640131009531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131009532 active site 640131009533 phosphorylation site [posttranslational modification] 640131009534 intermolecular recognition site; other site 640131009535 dimerization interface [polypeptide binding]; other site 640131009536 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 640131009537 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131009538 active site 640131009539 phosphorylation site [posttranslational modification] 640131009540 intermolecular recognition site; other site 640131009541 dimerization interface [polypeptide binding]; other site 640131009542 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 640131009543 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131009544 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131009545 active site 640131009546 catalytic tetrad [active] 640131009547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131009548 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131009549 putative substrate translocation pore; other site 640131009550 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 640131009551 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009552 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009553 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 640131009554 putative effector binding pocket; other site 640131009555 putative dimerization interface [polypeptide binding]; other site 640131009556 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 640131009557 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 640131009558 catalytic residues [active] 640131009559 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 640131009560 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131009561 Walker A/P-loop; other site 640131009562 ATP binding site [chemical binding]; other site 640131009563 Q-loop/lid; other site 640131009564 ABC transporter signature motif; other site 640131009565 Walker B; other site 640131009566 D-loop; other site 640131009567 H-loop/switch region; other site 640131009568 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131009569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009570 dimer interface [polypeptide binding]; other site 640131009571 conserved gate region; other site 640131009572 putative PBP binding loops; other site 640131009573 ABC-ATPase subunit interface; other site 640131009574 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131009575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009576 dimer interface [polypeptide binding]; other site 640131009577 conserved gate region; other site 640131009578 putative PBP binding loops; other site 640131009579 ABC-ATPase subunit interface; other site 640131009580 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 640131009581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131009582 membrane-bound complex binding site; other site 640131009583 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009584 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009585 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131009586 dimerization interface [polypeptide binding]; other site 640131009587 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131009588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009589 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131009590 dimerization interface [polypeptide binding]; other site 640131009591 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131009592 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131009593 substrate binding pocket [chemical binding]; other site 640131009594 membrane-bound complex binding site; other site 640131009595 hinge residues; other site 640131009596 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131009597 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131009598 Walker A/P-loop; other site 640131009599 ATP binding site [chemical binding]; other site 640131009600 Q-loop/lid; other site 640131009601 ABC transporter signature motif; other site 640131009602 Walker B; other site 640131009603 D-loop; other site 640131009604 H-loop/switch region; other site 640131009605 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131009606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009607 dimer interface [polypeptide binding]; other site 640131009608 conserved gate region; other site 640131009609 putative PBP binding loops; other site 640131009610 ABC-ATPase subunit interface; other site 640131009611 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 640131009612 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 640131009613 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 640131009614 peptide binding site [polypeptide binding]; other site 640131009615 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 640131009616 putative active site [active] 640131009617 Zn binding site [ion binding]; other site 640131009618 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 640131009619 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 640131009620 active site 640131009621 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 640131009622 dimer interface [polypeptide binding]; other site 640131009623 catalytic triad [active] 640131009624 peroxidatic and resolving cysteines [active] 640131009625 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 640131009626 Putative ammonia monooxygenase; Region: AmoA; pfam05145 640131009627 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 640131009628 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 640131009629 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 640131009630 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131009631 putative active site [active] 640131009632 heme pocket [chemical binding]; other site 640131009633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131009634 Walker A motif; other site 640131009635 ATP binding site [chemical binding]; other site 640131009636 Walker B motif; other site 640131009637 arginine finger; other site 640131009638 hypothetical protein; Provisional; Region: PRK05415 640131009639 Domain of unknown function (DUF697); Region: DUF697; cl12064 640131009640 Predicted ATPase [General function prediction only]; Region: COG3106 640131009641 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 640131009642 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 640131009643 phage shock protein C; Region: phageshock_pspC; TIGR02978 640131009644 phage shock protein B; Provisional; Region: pspB; PRK09458 640131009645 phage shock protein PspA; Provisional; Region: PRK10698 640131009646 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 640131009647 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131009648 Walker A motif; other site 640131009649 ATP binding site [chemical binding]; other site 640131009650 Walker B motif; other site 640131009651 arginine finger; other site 640131009652 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131009653 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131009654 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131009655 putative substrate translocation pore; other site 640131009656 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131009657 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 640131009658 metal binding site [ion binding]; metal-binding site 640131009659 putative dimer interface [polypeptide binding]; other site 640131009660 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131009661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131009662 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 640131009663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131009664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131009665 salt bridge; other site 640131009666 non-specific DNA binding site [nucleotide binding]; other site 640131009667 sequence-specific DNA binding site [nucleotide binding]; other site 640131009668 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 640131009669 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 640131009670 putative NAD(P) binding site [chemical binding]; other site 640131009671 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 640131009672 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 640131009673 peptide binding site [polypeptide binding]; other site 640131009674 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 640131009675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009676 dimer interface [polypeptide binding]; other site 640131009677 conserved gate region; other site 640131009678 putative PBP binding loops; other site 640131009679 ABC-ATPase subunit interface; other site 640131009680 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 640131009681 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131009682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009683 dimer interface [polypeptide binding]; other site 640131009684 conserved gate region; other site 640131009685 putative PBP binding loops; other site 640131009686 ABC-ATPase subunit interface; other site 640131009687 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 640131009688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131009689 Walker A/P-loop; other site 640131009690 ATP binding site [chemical binding]; other site 640131009691 Q-loop/lid; other site 640131009692 ABC transporter signature motif; other site 640131009693 Walker B; other site 640131009694 D-loop; other site 640131009695 H-loop/switch region; other site 640131009696 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131009697 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 640131009698 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131009699 Walker A/P-loop; other site 640131009700 ATP binding site [chemical binding]; other site 640131009701 Q-loop/lid; other site 640131009702 ABC transporter signature motif; other site 640131009703 Walker B; other site 640131009704 D-loop; other site 640131009705 H-loop/switch region; other site 640131009706 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 640131009707 active sites [active] 640131009708 tetramer interface [polypeptide binding]; other site 640131009709 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 640131009710 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131009711 Walker A/P-loop; other site 640131009712 ATP binding site [chemical binding]; other site 640131009713 Q-loop/lid; other site 640131009714 ABC transporter signature motif; other site 640131009715 Walker B; other site 640131009716 D-loop; other site 640131009717 H-loop/switch region; other site 640131009718 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009719 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131009720 dimer interface [polypeptide binding]; other site 640131009721 conserved gate region; other site 640131009722 putative PBP binding loops; other site 640131009723 ABC-ATPase subunit interface; other site 640131009724 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131009725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009726 dimer interface [polypeptide binding]; other site 640131009727 conserved gate region; other site 640131009728 putative PBP binding loops; other site 640131009729 ABC-ATPase subunit interface; other site 640131009730 lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096 640131009731 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131009732 substrate binding pocket [chemical binding]; other site 640131009733 membrane-bound complex binding site; other site 640131009734 hinge residues; other site 640131009735 HutD; Region: HutD; pfam05962 640131009736 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 640131009737 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 640131009738 NAD binding site [chemical binding]; other site 640131009739 homotetramer interface [polypeptide binding]; other site 640131009740 homodimer interface [polypeptide binding]; other site 640131009741 substrate binding site [chemical binding]; other site 640131009742 active site 640131009743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 640131009744 Uncharacterized conserved protein [Function unknown]; Region: COG2128 640131009745 exoribonuclease II; Provisional; Region: PRK05054 640131009746 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 640131009747 RNB domain; Region: RNB; pfam00773 640131009748 S1 RNA binding domain; Region: S1; pfam00575 640131009749 hypothetical protein; Provisional; Region: PRK13658 640131009750 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 640131009751 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 640131009752 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131009753 lipoprotein; Provisional; Region: PRK10540 640131009754 translation initiation factor Sui1; Validated; Region: PRK06824 640131009755 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 640131009756 putative rRNA binding site [nucleotide binding]; other site 640131009757 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 640131009758 active site 640131009759 dimer interface [polypeptide binding]; other site 640131009760 tetratricopeptide repeat protein; Provisional; Region: PRK11788 640131009761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 640131009762 TPR motif; other site 640131009763 binding surface 640131009764 Predicted membrane protein [Function unknown]; Region: COG3771 640131009765 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 640131009766 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 640131009767 active site 640131009768 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 640131009769 dimerization interface [polypeptide binding]; other site 640131009770 active site 640131009771 aconitate hydratase; Validated; Region: PRK09277 640131009772 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 640131009773 substrate binding site [chemical binding]; other site 640131009774 ligand binding site [chemical binding]; other site 640131009775 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 640131009776 substrate binding site [chemical binding]; other site 640131009777 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 640131009778 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009779 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 640131009780 substrate binding site [chemical binding]; other site 640131009781 putative dimerization interface [polypeptide binding]; other site 640131009782 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 640131009783 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 640131009784 active site 640131009785 interdomain interaction site; other site 640131009786 putative metal-binding site [ion binding]; other site 640131009787 nucleotide binding site [chemical binding]; other site 640131009788 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 640131009789 domain I; other site 640131009790 DNA binding groove [nucleotide binding] 640131009791 phosphate binding site [ion binding]; other site 640131009792 domain II; other site 640131009793 domain III; other site 640131009794 nucleotide binding site [chemical binding]; other site 640131009795 catalytic site [active] 640131009796 domain IV; other site 640131009797 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 640131009798 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 640131009799 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 640131009800 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 640131009801 hypothetical protein; Provisional; Region: PRK11037 640131009802 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 640131009803 putative inner membrane peptidase; Provisional; Region: PRK11778 640131009804 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 640131009805 tandem repeat interface [polypeptide binding]; other site 640131009806 oligomer interface [polypeptide binding]; other site 640131009807 active site residues [active] 640131009808 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 640131009809 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 640131009810 NADP binding site [chemical binding]; other site 640131009811 homodimer interface [polypeptide binding]; other site 640131009812 active site 640131009813 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 640131009814 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 640131009815 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 640131009816 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131009817 RNA binding surface [nucleotide binding]; other site 640131009818 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 640131009819 probable active site [active] 640131009820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131009821 active site 640131009822 phosphorylation site [posttranslational modification] 640131009823 intermolecular recognition site; other site 640131009824 hypothetical protein; Provisional; Region: PRK11630 640131009825 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 640131009826 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 640131009827 active site 640131009828 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 640131009829 anthranilate synthase component I; Provisional; Region: PRK13564 640131009830 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 640131009831 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 640131009832 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 640131009833 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 640131009834 glutamine binding [chemical binding]; other site 640131009835 catalytic triad [active] 640131009836 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 640131009837 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 640131009838 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 640131009839 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 640131009840 active site 640131009841 ribulose/triose binding site [chemical binding]; other site 640131009842 phosphate binding site [ion binding]; other site 640131009843 substrate (anthranilate) binding pocket [chemical binding]; other site 640131009844 product (indole) binding pocket [chemical binding]; other site 640131009845 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 640131009846 active site 640131009847 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 640131009848 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 640131009849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131009850 catalytic residue [active] 640131009851 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 640131009852 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 640131009853 substrate binding site [chemical binding]; other site 640131009854 active site 640131009855 catalytic residues [active] 640131009856 heterodimer interface [polypeptide binding]; other site 640131009857 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 640131009858 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 640131009859 MOFRL family; Region: MOFRL; pfam05161 640131009860 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 640131009861 tartrate dehydrogenase; Region: TTC; TIGR02089 640131009862 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 640131009863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131009864 putative substrate translocation pore; other site 640131009865 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 640131009866 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131009867 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 640131009868 dimerization interface [polypeptide binding]; other site 640131009869 substrate binding pocket [chemical binding]; other site 640131009870 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131009871 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131009872 putative DNA binding site [nucleotide binding]; other site 640131009873 putative Zn2+ binding site [ion binding]; other site 640131009874 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 640131009875 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 640131009876 putative NAD(P) binding site [chemical binding]; other site 640131009877 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 640131009878 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131009879 N-terminal plug; other site 640131009880 ligand-binding site [chemical binding]; other site 640131009881 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 640131009882 outer membrane protein W; Provisional; Region: PRK10959 640131009883 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 640131009884 hypothetical protein; Provisional; Region: PRK02868 640131009885 intracellular septation protein A; Reviewed; Region: PRK00259 640131009886 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 640131009887 YniB-like protein; Region: YniB; pfam14002 640131009888 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 640131009889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131009890 motif II; other site 640131009891 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 640131009892 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 640131009893 NADP binding site [chemical binding]; other site 640131009894 homodimer interface [polypeptide binding]; other site 640131009895 active site 640131009896 inner membrane protein; Provisional; Region: PRK11648 640131009897 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 640131009898 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 640131009899 cell division modulator; Provisional; Region: PRK10113 640131009900 hydroperoxidase II; Provisional; Region: katE; PRK11249 640131009901 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 640131009902 tetramer interface [polypeptide binding]; other site 640131009903 heme binding pocket [chemical binding]; other site 640131009904 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 640131009905 domain interactions; other site 640131009906 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 640131009907 putative active site [active] 640131009908 YdjC motif; other site 640131009909 Mg binding site [ion binding]; other site 640131009910 putative homodimer interface [polypeptide binding]; other site 640131009911 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 640131009912 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 640131009913 NAD binding site [chemical binding]; other site 640131009914 sugar binding site [chemical binding]; other site 640131009915 divalent metal binding site [ion binding]; other site 640131009916 tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131009917 dimer interface [polypeptide binding]; other site 640131009918 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 640131009919 Cupin domain; Region: Cupin_2; pfam07883 640131009920 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131009921 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 640131009922 methionine cluster; other site 640131009923 active site 640131009924 phosphorylation site [posttranslational modification] 640131009925 metal binding site [ion binding]; metal-binding site 640131009926 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 640131009927 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 640131009928 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 640131009929 active site 640131009930 P-loop; other site 640131009931 phosphorylation site [posttranslational modification] 640131009932 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 640131009933 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 640131009934 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 640131009935 homodimer interface [polypeptide binding]; other site 640131009936 NAD binding pocket [chemical binding]; other site 640131009937 ATP binding pocket [chemical binding]; other site 640131009938 Mg binding site [ion binding]; other site 640131009939 active-site loop [active] 640131009940 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 640131009941 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 640131009942 GIY-YIG motif/motif A; other site 640131009943 active site 640131009944 catalytic site [active] 640131009945 putative DNA binding site [nucleotide binding]; other site 640131009946 metal binding site [ion binding]; metal-binding site 640131009947 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 640131009948 dimer interface [polypeptide binding]; other site 640131009949 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 640131009950 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 640131009951 putative active site [active] 640131009952 Zn binding site [ion binding]; other site 640131009953 succinylarginine dihydrolase; Provisional; Region: PRK13281 640131009954 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 640131009955 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 640131009956 NAD(P) binding site [chemical binding]; other site 640131009957 catalytic residues [active] 640131009958 arginine succinyltransferase; Provisional; Region: PRK10456 640131009959 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 640131009960 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 640131009961 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131009962 inhibitor-cofactor binding pocket; inhibition site 640131009963 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131009964 catalytic residue [active] 640131009965 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 640131009966 putative catalytic site [active] 640131009967 putative phosphate binding site [ion binding]; other site 640131009968 active site 640131009969 metal binding site A [ion binding]; metal-binding site 640131009970 DNA binding site [nucleotide binding] 640131009971 putative AP binding site [nucleotide binding]; other site 640131009972 putative metal binding site B [ion binding]; other site 640131009973 Uncharacterized conserved protein [Function unknown]; Region: COG0398 640131009974 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 640131009975 Uncharacterized conserved protein [Function unknown]; Region: COG0398 640131009976 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 640131009977 Uncharacterized conserved protein [Function unknown]; Region: COG2128 640131009978 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 640131009979 hypothetical protein; Provisional; Region: PRK11622 640131009980 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 640131009981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131009982 ABC-ATPase subunit interface; other site 640131009983 putative PBP binding loops; other site 640131009984 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 640131009985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131009986 Walker A/P-loop; other site 640131009987 ATP binding site [chemical binding]; other site 640131009988 Q-loop/lid; other site 640131009989 ABC transporter signature motif; other site 640131009990 Walker B; other site 640131009991 D-loop; other site 640131009992 H-loop/switch region; other site 640131009993 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 640131009994 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 640131009995 active site residue [active] 640131009996 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 640131009997 active site residue [active] 640131009998 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 640131009999 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 640131010000 active site 640131010001 8-oxo-dGMP binding site [chemical binding]; other site 640131010002 nudix motif; other site 640131010003 metal binding site [ion binding]; metal-binding site 640131010004 glutamate dehydrogenase; Provisional; Region: PRK09414 640131010005 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 640131010006 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 640131010007 NAD(P) binding site [chemical binding]; other site 640131010008 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 640131010009 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 640131010010 NAD(P) binding site [chemical binding]; other site 640131010011 DNA topoisomerase III; Provisional; Region: PRK07726 640131010012 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 640131010013 active site 640131010014 putative interdomain interaction site [polypeptide binding]; other site 640131010015 putative metal-binding site [ion binding]; other site 640131010016 putative nucleotide binding site [chemical binding]; other site 640131010017 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 640131010018 domain I; other site 640131010019 DNA binding groove [nucleotide binding] 640131010020 phosphate binding site [ion binding]; other site 640131010021 domain II; other site 640131010022 domain III; other site 640131010023 nucleotide binding site [chemical binding]; other site 640131010024 catalytic site [active] 640131010025 domain IV; other site 640131010026 selenophosphate synthetase; Provisional; Region: PRK00943 640131010027 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 640131010028 dimerization interface [polypeptide binding]; other site 640131010029 putative ATP binding site [chemical binding]; other site 640131010030 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 640131010031 active site 640131010032 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 640131010033 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 640131010034 putative FMN binding site [chemical binding]; other site 640131010035 protease 4; Provisional; Region: PRK10949 640131010036 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 640131010037 tandem repeat interface [polypeptide binding]; other site 640131010038 oligomer interface [polypeptide binding]; other site 640131010039 active site residues [active] 640131010040 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 640131010041 tandem repeat interface [polypeptide binding]; other site 640131010042 oligomer interface [polypeptide binding]; other site 640131010043 active site residues [active] 640131010044 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 640131010045 active site 640131010046 homodimer interface [polypeptide binding]; other site 640131010047 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 640131010048 Isochorismatase family; Region: Isochorismatase; pfam00857 640131010049 catalytic triad [active] 640131010050 metal binding site [ion binding]; metal-binding site 640131010051 conserved cis-peptide bond; other site 640131010052 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 640131010053 Glyco_18 domain; Region: Glyco_18; smart00636 640131010054 active site 640131010055 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 640131010056 active site 640131010057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 640131010058 methionine sulfoxide reductase B; Provisional; Region: PRK00222 640131010059 SelR domain; Region: SelR; pfam01641 640131010060 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 640131010061 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 640131010062 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 640131010063 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 640131010064 active site 640131010065 phosphate binding residues; other site 640131010066 catalytic residues [active] 640131010067 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131010068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131010069 active site 640131010070 catalytic tetrad [active] 640131010071 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 640131010072 PrkA family serine protein kinase; Provisional; Region: PRK15455 640131010073 AAA ATPase domain; Region: AAA_16; pfam13191 640131010074 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 640131010075 Walker A motif; other site 640131010076 ATP binding site [chemical binding]; other site 640131010077 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 640131010078 hypothetical protein; Provisional; Region: PRK05325 640131010079 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 640131010080 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 640131010081 catalytic residues [active] 640131010082 dimer interface [polypeptide binding]; other site 640131010083 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131010084 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010085 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131010086 dimerization interface [polypeptide binding]; other site 640131010087 putative effector binding pocket; other site 640131010088 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 640131010089 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 640131010090 NAD(P) binding site [chemical binding]; other site 640131010091 active site 640131010092 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131010093 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131010095 dimerization interface [polypeptide binding]; other site 640131010096 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131010097 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 640131010098 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 640131010099 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 640131010100 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131010101 Walker A/P-loop; other site 640131010102 ATP binding site [chemical binding]; other site 640131010103 Q-loop/lid; other site 640131010104 ABC transporter signature motif; other site 640131010105 Walker B; other site 640131010106 D-loop; other site 640131010107 H-loop/switch region; other site 640131010108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010109 dimer interface [polypeptide binding]; other site 640131010110 conserved gate region; other site 640131010111 putative PBP binding loops; other site 640131010112 ABC-ATPase subunit interface; other site 640131010113 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 640131010114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131010115 substrate binding pocket [chemical binding]; other site 640131010116 membrane-bound complex binding site; other site 640131010117 hinge residues; other site 640131010118 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 640131010119 hypothetical protein; Provisional; Region: PRK07483 640131010120 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131010121 inhibitor-cofactor binding pocket; inhibition site 640131010122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131010123 catalytic residue [active] 640131010124 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 640131010125 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131010126 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 640131010127 putative active site [active] 640131010128 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 640131010129 Helix-turn-helix domain; Region: HTH_18; pfam12833 640131010130 short chain dehydrogenase; Validated; Region: PRK06182 640131010131 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 640131010132 NADP binding site [chemical binding]; other site 640131010133 active site 640131010134 steroid binding site; other site 640131010135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131010136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010137 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131010138 putative effector binding pocket; other site 640131010139 dimerization interface [polypeptide binding]; other site 640131010140 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 640131010141 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 640131010142 FMN binding site [chemical binding]; other site 640131010143 active site 640131010144 substrate binding site [chemical binding]; other site 640131010145 catalytic residue [active] 640131010146 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 640131010147 short chain dehydrogenase; Provisional; Region: PRK06500 640131010148 classical (c) SDRs; Region: SDR_c; cd05233 640131010149 NAD(P) binding site [chemical binding]; other site 640131010150 active site 640131010151 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131010152 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010153 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 640131010154 putative effector binding pocket; other site 640131010155 putative dimerization interface [polypeptide binding]; other site 640131010156 magnesium-transporting ATPase; Provisional; Region: PRK15122 640131010157 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 640131010158 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131010159 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 640131010160 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 640131010161 Soluble P-type ATPase [General function prediction only]; Region: COG4087 640131010162 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 640131010163 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 640131010164 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 640131010165 PhoU domain; Region: PhoU; pfam01895 640131010166 PhoU domain; Region: PhoU; pfam01895 640131010167 Protein of unknown function (DUF2493); Region: DUF2493; pfam10686 640131010168 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 640131010169 hypothetical protein; Provisional; Region: PRK07236 640131010170 tetracycline repressor protein TetR; Provisional; Region: PRK13756 640131010171 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010172 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 640131010173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010174 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131010175 putative substrate translocation pore; other site 640131010176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 640131010178 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 640131010179 putative NAD(P) binding site [chemical binding]; other site 640131010180 putative active site [active] 640131010181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131010182 DNA-binding site [nucleotide binding]; DNA binding site 640131010183 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131010184 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131010185 FCD domain; Region: FCD; pfam07729 640131010186 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131010187 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131010188 substrate binding pocket [chemical binding]; other site 640131010189 membrane-bound complex binding site; other site 640131010190 hinge residues; other site 640131010191 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131010192 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010193 dimer interface [polypeptide binding]; other site 640131010194 conserved gate region; other site 640131010195 putative PBP binding loops; other site 640131010196 ABC-ATPase subunit interface; other site 640131010197 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131010198 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131010199 Walker A/P-loop; other site 640131010200 ATP binding site [chemical binding]; other site 640131010201 Q-loop/lid; other site 640131010202 ABC transporter signature motif; other site 640131010203 Walker B; other site 640131010204 D-loop; other site 640131010205 H-loop/switch region; other site 640131010206 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 640131010207 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 640131010208 metal binding site [ion binding]; metal-binding site 640131010209 dimer interface [polypeptide binding]; other site 640131010210 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 640131010211 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 640131010212 metal binding site [ion binding]; metal-binding site 640131010213 substrate binding pocket [chemical binding]; other site 640131010214 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 640131010215 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 640131010216 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 640131010217 active site 640131010218 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 640131010219 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 640131010220 inhibitor site; inhibition site 640131010221 active site 640131010222 dimer interface [polypeptide binding]; other site 640131010223 catalytic residue [active] 640131010224 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 640131010225 Glutamine amidotransferase class-I; Region: GATase; pfam00117 640131010226 conserved cys residue [active] 640131010227 aspartate aminotransferase; Provisional; Region: PRK05764 640131010228 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131010229 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131010230 homodimer interface [polypeptide binding]; other site 640131010231 catalytic residue [active] 640131010232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131010233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010234 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 640131010235 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Saccharomyces cerevisiae biotin-apoprotein ligase (ScBLP); Region: GATase1_ScBLP_like; cd03144 640131010236 conserved cys residue [active] 640131010237 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 640131010238 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 640131010239 Catalytic site [active] 640131010240 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 640131010241 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 640131010242 active site 640131010243 DNA binding site [nucleotide binding] 640131010244 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 640131010245 DinI-like family; Region: DinI; cl11630 640131010246 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 640131010247 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 640131010248 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 640131010249 putative deacylase active site [active] 640131010250 Predicted membrane protein [Function unknown]; Region: COG2707 640131010251 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131010252 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 640131010253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010254 hypothetical protein; Validated; Region: PRK06186 640131010255 conserved cys residue [active] 640131010256 Uncharacterized conserved protein [Function unknown]; Region: COG1683 640131010257 Uncharacterized conserved protein [Function unknown]; Region: COG3189 640131010258 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 640131010259 Domain of unknown function (DUF333); Region: DUF333; pfam03891 640131010260 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 640131010261 Phage-related protein [Function unknown]; Region: COG4695; cl01923 640131010262 Phage portal protein; Region: Phage_portal; pfam04860 640131010263 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 640131010264 voltage-gated potassium channel; Provisional; Region: PRK10537 640131010265 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 640131010266 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 640131010267 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 640131010268 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131010269 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131010270 metal binding site [ion binding]; metal-binding site 640131010271 active site 640131010272 I-site; other site 640131010273 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 640131010274 leucine export protein LeuE; Provisional; Region: PRK10958 640131010275 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 640131010276 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 640131010277 putative acyl-acceptor binding pocket; other site 640131010278 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 640131010279 active site 640131010280 homotetramer interface [polypeptide binding]; other site 640131010281 homodimer interface [polypeptide binding]; other site 640131010282 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131010283 Zn2+ binding site [ion binding]; other site 640131010284 Mg2+ binding site [ion binding]; other site 640131010285 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131010286 Zn2+ binding site [ion binding]; other site 640131010287 Mg2+ binding site [ion binding]; other site 640131010288 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131010289 dimerization interface [polypeptide binding]; other site 640131010290 GAF domain; Region: GAF; cl17456 640131010291 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131010292 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131010293 metal binding site [ion binding]; metal-binding site 640131010294 active site 640131010295 I-site; other site 640131010296 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 640131010297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010298 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 640131010299 dimerization interface [polypeptide binding]; other site 640131010300 substrate binding pocket [chemical binding]; other site 640131010301 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 640131010302 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 640131010303 dimer interface [polypeptide binding]; other site 640131010304 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131010305 Helix-turn-helix domain; Region: HTH_39; pfam14090 640131010306 Cupin domain; Region: Cupin_2; cl17218 640131010307 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131010308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131010309 Fusaric acid resistance protein family; Region: FUSC; pfam04632 640131010310 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 640131010311 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 640131010312 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131010313 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131010314 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 640131010315 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 640131010316 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 640131010317 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 640131010318 dimanganese center [ion binding]; other site 640131010319 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 640131010320 dinuclear metal binding motif [ion binding]; other site 640131010321 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 640131010322 dimerization interface [polypeptide binding]; other site 640131010323 metal binding site [ion binding]; metal-binding site 640131010324 General stress protein [General function prediction only]; Region: GsiB; COG3729 640131010325 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 640131010326 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 640131010327 NAD binding site [chemical binding]; other site 640131010328 catalytic Zn binding site [ion binding]; other site 640131010329 structural Zn binding site [ion binding]; other site 640131010330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 640131010331 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 640131010332 Isochorismatase family; Region: Isochorismatase; pfam00857 640131010333 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 640131010334 catalytic triad [active] 640131010335 conserved cis-peptide bond; other site 640131010336 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 640131010337 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131010338 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010339 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131010340 active site 640131010341 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 640131010342 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 640131010343 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 640131010344 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 640131010345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131010346 dimerization interface [polypeptide binding]; other site 640131010347 putative DNA binding site [nucleotide binding]; other site 640131010348 putative Zn2+ binding site [ion binding]; other site 640131010349 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 640131010350 Amidase; Region: Amidase; pfam01425 640131010351 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 640131010352 Isochorismatase family; Region: Isochorismatase; pfam00857 640131010353 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 640131010354 catalytic triad [active] 640131010355 conserved cis-peptide bond; other site 640131010356 drug efflux system protein MdtG; Provisional; Region: PRK09874 640131010357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010358 putative substrate translocation pore; other site 640131010359 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131010360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131010361 DNA-binding site [nucleotide binding]; DNA binding site 640131010362 FCD domain; Region: FCD; pfam07729 640131010363 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 640131010364 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 640131010365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131010366 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131010367 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131010368 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 640131010369 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010370 putative substrate translocation pore; other site 640131010371 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010372 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 640131010373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131010374 Walker A motif; other site 640131010375 ATP binding site [chemical binding]; other site 640131010376 Walker B motif; other site 640131010377 arginine finger; other site 640131010378 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131010379 isocitrate dehydrogenase; Validated; Region: PRK07362 640131010380 isocitrate dehydrogenase; Reviewed; Region: PRK07006 640131010381 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 640131010382 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 640131010383 probable active site [active] 640131010384 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 640131010385 nudix motif; other site 640131010386 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 640131010387 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 640131010388 putative lysogenization regulator; Reviewed; Region: PRK00218 640131010389 adenylosuccinate lyase; Provisional; Region: PRK09285 640131010390 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 640131010391 tetramer interface [polypeptide binding]; other site 640131010392 active site 640131010393 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 640131010394 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131010395 Helix-turn-helix domain; Region: HTH_18; pfam12833 640131010396 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131010397 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 640131010398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131010399 active site 640131010400 phosphorylation site [posttranslational modification] 640131010401 intermolecular recognition site; other site 640131010402 dimerization interface [polypeptide binding]; other site 640131010403 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131010404 DNA binding site [nucleotide binding] 640131010405 sensor protein PhoQ; Provisional; Region: PRK10815 640131010406 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 640131010407 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 640131010408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131010409 ATP binding site [chemical binding]; other site 640131010410 Mg2+ binding site [ion binding]; other site 640131010411 G-X-G motif; other site 640131010412 Uncharacterized conserved protein [Function unknown]; Region: COG2850 640131010413 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 640131010414 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 640131010415 metal binding site [ion binding]; metal-binding site 640131010416 dimer interface [polypeptide binding]; other site 640131010417 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 640131010418 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 640131010419 Walker A/P-loop; other site 640131010420 ATP binding site [chemical binding]; other site 640131010421 Q-loop/lid; other site 640131010422 ABC transporter signature motif; other site 640131010423 Walker B; other site 640131010424 D-loop; other site 640131010425 H-loop/switch region; other site 640131010426 TOBE domain; Region: TOBE_2; pfam08402 640131010427 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131010428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010429 dimer interface [polypeptide binding]; other site 640131010430 conserved gate region; other site 640131010431 putative PBP binding loops; other site 640131010432 ABC-ATPase subunit interface; other site 640131010433 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131010434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010435 dimer interface [polypeptide binding]; other site 640131010436 conserved gate region; other site 640131010437 putative PBP binding loops; other site 640131010438 ABC-ATPase subunit interface; other site 640131010439 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 640131010440 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 640131010441 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 640131010442 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 640131010443 NAD(P) binding site [chemical binding]; other site 640131010444 catalytic residues [active] 640131010445 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 640131010446 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 640131010447 acyl-activating enzyme (AAE) consensus motif; other site 640131010448 AMP binding site [chemical binding]; other site 640131010449 active site 640131010450 CoA binding site [chemical binding]; other site 640131010451 transketolase; Reviewed; Region: PRK12753 640131010452 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 640131010453 TPP-binding site [chemical binding]; other site 640131010454 dimer interface [polypeptide binding]; other site 640131010455 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 640131010456 PYR/PP interface [polypeptide binding]; other site 640131010457 dimer interface [polypeptide binding]; other site 640131010458 TPP binding site [chemical binding]; other site 640131010459 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131010460 transaldolase-like protein; Provisional; Region: PTZ00411 640131010461 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 640131010462 active site 640131010463 dimer interface [polypeptide binding]; other site 640131010464 catalytic residue [active] 640131010465 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 640131010466 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 640131010467 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 640131010468 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 640131010469 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 640131010470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 640131010471 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 640131010472 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 640131010473 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 640131010474 substrate binding site [chemical binding]; other site 640131010475 dimer interface [polypeptide binding]; other site 640131010476 triosephosphate isomerase; Provisional; Region: PRK14565 640131010477 catalytic triad [active] 640131010478 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 640131010479 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 640131010480 DNA binding residues [nucleotide binding] 640131010481 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 640131010482 NAD-dependent deacetylase; Provisional; Region: PRK00481 640131010483 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 640131010484 NAD+ binding site [chemical binding]; other site 640131010485 substrate binding site [chemical binding]; other site 640131010486 Zn binding site [ion binding]; other site 640131010487 fructokinase; Reviewed; Region: PRK09557 640131010488 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131010489 nucleotide binding site [chemical binding]; other site 640131010490 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 640131010491 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 640131010492 FtsX-like permease family; Region: FtsX; pfam02687 640131010493 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 640131010494 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 640131010495 Walker A/P-loop; other site 640131010496 ATP binding site [chemical binding]; other site 640131010497 Q-loop/lid; other site 640131010498 ABC transporter signature motif; other site 640131010499 Walker B; other site 640131010500 D-loop; other site 640131010501 H-loop/switch region; other site 640131010502 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 640131010503 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 640131010504 FtsX-like permease family; Region: FtsX; pfam02687 640131010505 transcription-repair coupling factor; Provisional; Region: PRK10689 640131010506 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 640131010507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131010508 ATP binding site [chemical binding]; other site 640131010509 putative Mg++ binding site [ion binding]; other site 640131010510 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131010511 nucleotide binding region [chemical binding]; other site 640131010512 ATP-binding site [chemical binding]; other site 640131010513 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 640131010514 L,D-transpeptidase; Provisional; Region: PRK10190 640131010515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131010516 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 640131010517 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131010518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131010519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010520 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 640131010521 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131010522 N-terminal plug; other site 640131010523 ligand-binding site [chemical binding]; other site 640131010524 hypothetical protein; Provisional; Region: PRK11280 640131010525 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 640131010526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131010527 hypothetical protein; Provisional; Region: PRK04940 640131010528 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 640131010529 beta-hexosaminidase; Provisional; Region: PRK05337 640131010530 thiamine kinase; Region: ycfN_thiK; TIGR02721 640131010531 thiamine kinase; Provisional; Region: thiK; PRK10271 640131010532 substrate binding site [chemical binding]; other site 640131010533 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 640131010534 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 640131010535 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 640131010536 putative dimer interface [polypeptide binding]; other site 640131010537 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 640131010538 nucleotide binding site/active site [active] 640131010539 HIT family signature motif; other site 640131010540 catalytic residue [active] 640131010541 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 640131010542 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131010543 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131010544 active site turn [active] 640131010545 phosphorylation site [posttranslational modification] 640131010546 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 640131010547 active site 640131010548 DNA polymerase III subunit delta'; Validated; Region: PRK07993 640131010549 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 640131010550 thymidylate kinase; Validated; Region: tmk; PRK00698 640131010551 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 640131010552 TMP-binding site; other site 640131010553 ATP-binding site [chemical binding]; other site 640131010554 conserved hypothetical protein, YceG family; Region: TIGR00247 640131010555 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 640131010556 dimerization interface [polypeptide binding]; other site 640131010557 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 640131010558 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 640131010559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131010560 catalytic residue [active] 640131010561 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 640131010562 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 640131010563 dimer interface [polypeptide binding]; other site 640131010564 active site 640131010565 acyl carrier protein; Provisional; Region: acpP; PRK00982 640131010566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 640131010567 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 640131010568 NAD(P) binding site [chemical binding]; other site 640131010569 homotetramer interface [polypeptide binding]; other site 640131010570 homodimer interface [polypeptide binding]; other site 640131010571 active site 640131010572 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 640131010573 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 640131010574 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 640131010575 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 640131010576 dimer interface [polypeptide binding]; other site 640131010577 active site 640131010578 CoA binding pocket [chemical binding]; other site 640131010579 putative phosphate acyltransferase; Provisional; Region: PRK05331 640131010580 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 640131010581 hypothetical protein; Provisional; Region: PRK11193 640131010582 Maf-like protein; Region: Maf; pfam02545 640131010583 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 640131010584 active site 640131010585 dimer interface [polypeptide binding]; other site 640131010586 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 640131010587 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131010588 RNA binding surface [nucleotide binding]; other site 640131010589 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 640131010590 active site 640131010591 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 640131010592 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 640131010593 homodimer interface [polypeptide binding]; other site 640131010594 oligonucleotide binding site [chemical binding]; other site 640131010595 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 640131010596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131010597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010598 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131010599 putative effector binding pocket; other site 640131010600 dimerization interface [polypeptide binding]; other site 640131010601 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131010602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010603 putative substrate translocation pore; other site 640131010604 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 640131010605 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 640131010606 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131010607 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131010608 hypothetical protein; Provisional; Region: PRK11239 640131010609 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 640131010610 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 640131010611 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 640131010612 multidrug resistance protein MdtH; Provisional; Region: PRK11646 640131010613 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010614 putative substrate translocation pore; other site 640131010615 lipoprotein; Provisional; Region: PRK10598 640131010616 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 640131010617 active site 640131010618 substrate binding pocket [chemical binding]; other site 640131010619 dimer interface [polypeptide binding]; other site 640131010620 DNA damage-inducible protein I; Provisional; Region: PRK10597 640131010621 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 640131010622 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 640131010623 hydroxyglutarate oxidase; Provisional; Region: PRK11728 640131010624 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 640131010625 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 640131010626 active site residue [active] 640131010627 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 640131010628 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 640131010629 putative acyl-acceptor binding pocket; other site 640131010630 drug efflux system protein MdtG; Provisional; Region: PRK09874 640131010631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131010632 putative substrate translocation pore; other site 640131010633 secY/secA suppressor protein; Provisional; Region: PRK11467 640131010634 lipoprotein; Provisional; Region: PRK10175 640131010635 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 640131010636 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 640131010637 Ligand binding site; other site 640131010638 DXD motif; other site 640131010639 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 640131010640 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; cl15433 640131010641 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 640131010642 Acyltransferase family; Region: Acyl_transf_3; pfam01757 640131010643 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 640131010644 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010645 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 640131010646 putative ADP-ribose binding site [chemical binding]; other site 640131010647 putative active site [active] 640131010648 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 640131010649 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 640131010650 putative hydrolase; Validated; Region: PRK09248 640131010651 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 640131010652 active site 640131010653 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 640131010654 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 640131010655 putative ligand binding site [chemical binding]; other site 640131010656 NAD binding site [chemical binding]; other site 640131010657 dimerization interface [polypeptide binding]; other site 640131010658 catalytic site [active] 640131010659 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 640131010660 active site 640131010661 Mn binding site [ion binding]; other site 640131010662 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131010663 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010664 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 640131010665 LysR family transcriptional regulator; Provisional; Region: PRK14997 640131010666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010667 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_4; cd08473 640131010668 putative effector binding pocket; other site 640131010669 putative dimerization interface [polypeptide binding]; other site 640131010670 Pirin-related protein [General function prediction only]; Region: COG1741 640131010671 Pirin; Region: Pirin; pfam02678 640131010672 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 640131010673 Isochorismatase family; Region: Isochorismatase; pfam00857 640131010674 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 640131010675 catalytic triad [active] 640131010676 dimer interface [polypeptide binding]; other site 640131010677 conserved cis-peptide bond; other site 640131010678 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 640131010679 hypothetical protein; Provisional; Region: PRK10536 640131010680 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 640131010681 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 640131010682 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 640131010683 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 640131010684 Imelysin; Region: Peptidase_M75; pfam09375 640131010685 FTR1 family protein; Region: TIGR00145 640131010686 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 640131010687 Nucleoside recognition; Region: Gate; pfam07670 640131010688 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 640131010689 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 640131010690 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 640131010691 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 640131010692 Na binding site [ion binding]; other site 640131010693 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 640131010694 Predicted transcriptional regulator [Transcription]; Region: COG3905 640131010695 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 640131010696 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 640131010697 Glutamate binding site [chemical binding]; other site 640131010698 NAD binding site [chemical binding]; other site 640131010699 catalytic residues [active] 640131010700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 640131010701 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 640131010702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131010703 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 640131010704 pyrimidine utilization protein A; Region: RutA; TIGR03612 640131010705 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 640131010706 active site 640131010707 dimer interface [polypeptide binding]; other site 640131010708 non-prolyl cis peptide bond; other site 640131010709 insertion regions; other site 640131010710 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 640131010711 Isochorismatase family; Region: Isochorismatase; pfam00857 640131010712 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 640131010713 catalytic triad [active] 640131010714 conserved cis-peptide bond; other site 640131010715 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 640131010716 homotrimer interaction site [polypeptide binding]; other site 640131010717 putative active site [active] 640131010718 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 640131010719 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 640131010720 putative FMN binding site [chemical binding]; other site 640131010721 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 640131010722 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 640131010723 EamA-like transporter family; Region: EamA; pfam00892 640131010724 General stress protein [General function prediction only]; Region: GsiB; COG3729 640131010725 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 640131010726 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 640131010727 hypothetical protein; Provisional; Region: PRK10174 640131010728 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 640131010729 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 640131010730 catalytic core [active] 640131010731 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 640131010732 Predicted transcriptional regulators [Transcription]; Region: COG1733 640131010733 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 640131010734 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 640131010735 classical (c) SDRs; Region: SDR_c; cd05233 640131010736 NAD(P) binding site [chemical binding]; other site 640131010737 active site 640131010738 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 640131010739 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 640131010740 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 640131010741 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 640131010742 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 640131010743 catalytic triad [active] 640131010744 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 640131010745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131010746 non-specific DNA binding site [nucleotide binding]; other site 640131010747 salt bridge; other site 640131010748 sequence-specific DNA binding site [nucleotide binding]; other site 640131010749 Cupin domain; Region: Cupin_2; pfam07883 640131010750 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 640131010751 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 640131010752 NAD(P) binding site [chemical binding]; other site 640131010753 catalytic residues [active] 640131010754 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 640131010755 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 640131010756 transcriptional activator TtdR; Provisional; Region: PRK09801 640131010757 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131010758 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 640131010759 putative effector binding pocket; other site 640131010760 putative dimerization interface [polypeptide binding]; other site 640131010761 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 640131010762 tartrate dehydrogenase; Region: TTC; TIGR02089 640131010763 putative transporter; Provisional; Region: PRK09950 640131010764 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 640131010765 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 640131010766 [2Fe-2S] cluster binding site [ion binding]; other site 640131010767 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 640131010768 putative alpha subunit interface [polypeptide binding]; other site 640131010769 putative active site [active] 640131010770 putative substrate binding site [chemical binding]; other site 640131010771 Fe binding site [ion binding]; other site 640131010772 succinic semialdehyde dehydrogenase; Region: PLN02278 640131010773 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 640131010774 tetramerization interface [polypeptide binding]; other site 640131010775 NAD(P) binding site [chemical binding]; other site 640131010776 catalytic residues [active] 640131010777 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 640131010778 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 640131010779 FMN-binding pocket [chemical binding]; other site 640131010780 flavin binding motif; other site 640131010781 phosphate binding motif [ion binding]; other site 640131010782 beta-alpha-beta structure motif; other site 640131010783 NAD binding pocket [chemical binding]; other site 640131010784 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131010785 catalytic loop [active] 640131010786 iron binding site [ion binding]; other site 640131010787 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 640131010788 dimerization domain swap beta strand [polypeptide binding]; other site 640131010789 regulatory protein interface [polypeptide binding]; other site 640131010790 active site 640131010791 regulatory phosphorylation site [posttranslational modification]; other site 640131010792 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 640131010793 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 640131010794 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 640131010795 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 640131010796 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131010797 active site 640131010798 phosphorylation site [posttranslational modification] 640131010799 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 640131010800 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 640131010801 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 640131010802 active site 640131010803 P-loop; other site 640131010804 phosphorylation site [posttranslational modification] 640131010805 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 640131010806 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 640131010807 dimer interface [polypeptide binding]; other site 640131010808 active site 640131010809 glycine loop; other site 640131010810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131010811 FeS/SAM binding site; other site 640131010812 pyruvate formate lyase II activase; Provisional; Region: PRK10076 640131010813 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 640131010814 active site 640131010815 P-loop; other site 640131010816 phosphorylation site [posttranslational modification] 640131010817 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 640131010818 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131010819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131010820 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131010821 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131010822 metal binding site [ion binding]; metal-binding site 640131010823 active site 640131010824 I-site; other site 640131010825 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 640131010826 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 640131010827 Walker A/P-loop; other site 640131010828 ATP binding site [chemical binding]; other site 640131010829 Q-loop/lid; other site 640131010830 ABC transporter signature motif; other site 640131010831 Walker B; other site 640131010832 D-loop; other site 640131010833 H-loop/switch region; other site 640131010834 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 640131010835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010836 dimer interface [polypeptide binding]; other site 640131010837 conserved gate region; other site 640131010838 ABC-ATPase subunit interface; other site 640131010839 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 640131010840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010841 dimer interface [polypeptide binding]; other site 640131010842 conserved gate region; other site 640131010843 putative PBP binding loops; other site 640131010844 ABC-ATPase subunit interface; other site 640131010845 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 640131010846 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 640131010847 phage resistance protein; Provisional; Region: PRK10551 640131010848 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 640131010849 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131010850 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 640131010851 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 640131010852 anti sigma factor interaction site; other site 640131010853 regulatory phosphorylation site [posttranslational modification]; other site 640131010854 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 640131010855 homodimer interface [polypeptide binding]; other site 640131010856 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 640131010857 active site pocket [active] 640131010858 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 640131010859 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 640131010860 peptide binding site [polypeptide binding]; other site 640131010861 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 640131010862 YccA-like proteins; Region: YccA_like; cd10433 640131010863 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 640131010864 sulfur transfer protein TusE; Provisional; Region: PRK11508 640131010865 acylphosphatase; Provisional; Region: PRK14426 640131010866 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131010867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131010868 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 640131010869 substrate binding site [chemical binding]; other site 640131010870 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 640131010871 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 640131010872 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 640131010873 putative RNA binding site [nucleotide binding]; other site 640131010874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131010875 S-adenosylmethionine binding site [chemical binding]; other site 640131010876 heat shock protein HspQ; Provisional; Region: PRK14129 640131010877 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 640131010878 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 640131010879 active site 640131010880 dimer interfaces [polypeptide binding]; other site 640131010881 catalytic residues [active] 640131010882 DNA helicase IV; Provisional; Region: helD; PRK11054 640131010883 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 640131010884 Part of AAA domain; Region: AAA_19; pfam13245 640131010885 Family description; Region: UvrD_C_2; pfam13538 640131010886 Predicted membrane protein [Function unknown]; Region: COG3304 640131010887 Domain of unknown function (DUF307); Region: DUF307; pfam03733 640131010888 Domain of unknown function (DUF307); Region: DUF307; pfam03733 640131010889 TIGR01666 family membrane protein; Region: YCCS 640131010890 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 640131010891 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 640131010892 TfoX N-terminal domain; Region: TfoX_N; pfam04993 640131010893 TfoX C-terminal domain; Region: TfoX_C; pfam04994 640131010894 SOS cell division inhibitor; Provisional; Region: PRK10595 640131010895 outer membrane protein A; Reviewed; Region: PRK10808 640131010896 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 640131010897 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 640131010898 ligand binding site [chemical binding]; other site 640131010899 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 640131010900 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 640131010901 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 640131010902 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 640131010903 active site 1 [active] 640131010904 dimer interface [polypeptide binding]; other site 640131010905 active site 2 [active] 640131010906 ribosome modulation factor; Provisional; Region: PRK14563 640131010907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 640131010908 Protein of unknown function (DUF330); Region: DUF330; pfam03886 640131010909 paraquat-inducible protein B; Provisional; Region: PRK10807 640131010910 mce related protein; Region: MCE; pfam02470 640131010911 mce related protein; Region: MCE; pfam02470 640131010912 mce related protein; Region: MCE; pfam02470 640131010913 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 640131010914 Paraquat-inducible protein A; Region: PqiA; pfam04403 640131010915 Paraquat-inducible protein A; Region: PqiA; pfam04403 640131010916 ABC transporter ATPase component; Reviewed; Region: PRK11147 640131010917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131010918 Walker A/P-loop; other site 640131010919 ATP binding site [chemical binding]; other site 640131010920 Q-loop/lid; other site 640131010921 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131010922 ABC transporter; Region: ABC_tran_2; pfam12848 640131010923 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131010924 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 640131010925 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 640131010926 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 640131010927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131010928 S-adenosylmethionine binding site [chemical binding]; other site 640131010929 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 640131010930 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 640131010931 MOSC domain; Region: MOSC; pfam03473 640131010932 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 640131010933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131010934 catalytic loop [active] 640131010935 iron binding site [ion binding]; other site 640131010936 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 640131010937 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 640131010938 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 640131010939 quinone interaction residues [chemical binding]; other site 640131010940 active site 640131010941 catalytic residues [active] 640131010942 FMN binding site [chemical binding]; other site 640131010943 substrate binding site [chemical binding]; other site 640131010944 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 640131010945 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 640131010946 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 640131010947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131010948 substrate binding pocket [chemical binding]; other site 640131010949 membrane-bound complex binding site; other site 640131010950 hinge residues; other site 640131010951 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 640131010952 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 640131010953 active site 640131010954 dimer interface [polypeptide binding]; other site 640131010955 non-prolyl cis peptide bond; other site 640131010956 insertion regions; other site 640131010957 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131010958 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131010959 dimer interface [polypeptide binding]; other site 640131010960 conserved gate region; other site 640131010961 putative PBP binding loops; other site 640131010962 ABC-ATPase subunit interface; other site 640131010963 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 640131010964 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131010965 Walker A/P-loop; other site 640131010966 ATP binding site [chemical binding]; other site 640131010967 Q-loop/lid; other site 640131010968 ABC transporter signature motif; other site 640131010969 Walker B; other site 640131010970 D-loop; other site 640131010971 H-loop/switch region; other site 640131010972 aminopeptidase N; Provisional; Region: pepN; PRK14015 640131010973 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 640131010974 active site 640131010975 Zn binding site [ion binding]; other site 640131010976 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 640131010977 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 640131010978 active site 640131010979 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 640131010980 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 640131010981 putative dimer interface [polypeptide binding]; other site 640131010982 putative anticodon binding site; other site 640131010983 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 640131010984 homodimer interface [polypeptide binding]; other site 640131010985 motif 1; other site 640131010986 motif 2; other site 640131010987 active site 640131010988 motif 3; other site 640131010989 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 640131010990 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 640131010991 eyelet of channel; other site 640131010992 trimer interface [polypeptide binding]; other site 640131010993 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 640131010994 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131010995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131010996 homodimer interface [polypeptide binding]; other site 640131010997 catalytic residue [active] 640131010998 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 640131010999 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 640131011000 Peptidase M15; Region: Peptidase_M15_3; cl01194 640131011001 murein L,D-transpeptidase; Provisional; Region: PRK10594 640131011002 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 640131011003 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 640131011004 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 640131011005 cell division protein MukB; Provisional; Region: mukB; PRK04863 640131011006 P-loop containing region of AAA domain; Region: AAA_29; cl17516 640131011007 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 640131011008 condesin subunit E; Provisional; Region: PRK05256 640131011009 condesin subunit F; Provisional; Region: PRK05260 640131011010 Methyltransferase domain; Region: Methyltransf_31; pfam13847 640131011011 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131011012 S-adenosylmethionine binding site [chemical binding]; other site 640131011013 Uncharacterized conserved protein [Function unknown]; Region: COG1434 640131011014 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 640131011015 putative active site [active] 640131011016 hypothetical protein; Provisional; Region: PRK10593 640131011017 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 640131011018 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 640131011019 Ligand binding site; other site 640131011020 oligomer interface; other site 640131011021 Trm112p-like protein; Region: Trm112p; cl01066 640131011022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 640131011023 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 640131011024 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 640131011025 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 640131011026 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 640131011027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 640131011028 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 640131011029 Walker A/P-loop; other site 640131011030 ATP binding site [chemical binding]; other site 640131011031 Q-loop/lid; other site 640131011032 ABC transporter signature motif; other site 640131011033 Walker B; other site 640131011034 D-loop; other site 640131011035 H-loop/switch region; other site 640131011036 ComEC family competence protein; Provisional; Region: PRK11539 640131011037 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 640131011038 Competence protein; Region: Competence; pfam03772 640131011039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 640131011040 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 640131011041 IHF dimer interface [polypeptide binding]; other site 640131011042 IHF - DNA interface [nucleotide binding]; other site 640131011043 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 640131011044 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 640131011045 RNA binding site [nucleotide binding]; other site 640131011046 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 640131011047 RNA binding site [nucleotide binding]; other site 640131011048 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 640131011049 RNA binding site [nucleotide binding]; other site 640131011050 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 640131011051 RNA binding site [nucleotide binding]; other site 640131011052 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 640131011053 RNA binding site [nucleotide binding]; other site 640131011054 cytidylate kinase; Provisional; Region: cmk; PRK00023 640131011055 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 640131011056 CMP-binding site; other site 640131011057 The sites determining sugar specificity; other site 640131011058 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 640131011059 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 640131011060 hinge; other site 640131011061 active site 640131011062 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 640131011063 homodimer interface [polypeptide binding]; other site 640131011064 substrate-cofactor binding pocket; other site 640131011065 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131011066 catalytic residue [active] 640131011067 Predicted membrane protein [Function unknown]; Region: COG2323 640131011068 uncharacterized domain; Region: TIGR00702 640131011069 YcaO-like family; Region: YcaO; pfam02624 640131011070 formate transporter; Provisional; Region: PRK10805 640131011071 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 640131011072 Pyruvate formate lyase 1; Region: PFL1; cd01678 640131011073 coenzyme A binding site [chemical binding]; other site 640131011074 active site 640131011075 catalytic residues [active] 640131011076 glycine loop; other site 640131011077 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 640131011078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131011079 FeS/SAM binding site; other site 640131011080 putative MFS family transporter protein; Provisional; Region: PRK03633 640131011081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011082 putative substrate translocation pore; other site 640131011083 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 640131011084 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 640131011085 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 640131011086 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 640131011087 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 640131011088 putative [Fe4-S4] binding site [ion binding]; other site 640131011089 putative molybdopterin cofactor binding site [chemical binding]; other site 640131011090 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 640131011091 putative molybdopterin cofactor binding site; other site 640131011092 seryl-tRNA synthetase; Provisional; Region: PRK05431 640131011093 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 640131011094 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 640131011095 dimer interface [polypeptide binding]; other site 640131011096 active site 640131011097 motif 1; other site 640131011098 motif 2; other site 640131011099 motif 3; other site 640131011100 recombination factor protein RarA; Reviewed; Region: PRK13342 640131011101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131011102 Walker A motif; other site 640131011103 ATP binding site [chemical binding]; other site 640131011104 Walker B motif; other site 640131011105 arginine finger; other site 640131011106 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 640131011107 periplasmic chaperone LolA; Region: lolA; TIGR00547 640131011108 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 640131011109 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 640131011110 DNA translocase FtsK; Provisional; Region: PRK10263 640131011111 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 640131011112 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 640131011113 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 640131011114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131011115 putative DNA binding site [nucleotide binding]; other site 640131011116 putative Zn2+ binding site [ion binding]; other site 640131011117 AsnC family; Region: AsnC_trans_reg; pfam01037 640131011118 thioredoxin reductase; Provisional; Region: PRK10262 640131011119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131011120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131011121 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 640131011122 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 640131011123 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011124 Walker A/P-loop; other site 640131011125 ATP binding site [chemical binding]; other site 640131011126 Q-loop/lid; other site 640131011127 ABC transporter signature motif; other site 640131011128 Walker B; other site 640131011129 D-loop; other site 640131011130 H-loop/switch region; other site 640131011131 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 640131011132 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 640131011133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011134 Walker A/P-loop; other site 640131011135 ATP binding site [chemical binding]; other site 640131011136 Q-loop/lid; other site 640131011137 ABC transporter signature motif; other site 640131011138 Walker B; other site 640131011139 D-loop; other site 640131011140 H-loop/switch region; other site 640131011141 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 640131011142 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 640131011143 rRNA binding site [nucleotide binding]; other site 640131011144 predicted 30S ribosome binding site; other site 640131011145 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 640131011146 Clp amino terminal domain; Region: Clp_N; pfam02861 640131011147 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131011148 Walker A motif; other site 640131011149 ATP binding site [chemical binding]; other site 640131011150 Walker B motif; other site 640131011151 arginine finger; other site 640131011152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131011153 Walker A motif; other site 640131011154 ATP binding site [chemical binding]; other site 640131011155 Walker B motif; other site 640131011156 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 640131011157 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 640131011158 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 640131011159 DNA-binding site [nucleotide binding]; DNA binding site 640131011160 RNA-binding motif; other site 640131011161 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 640131011162 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 640131011163 Walker A/P-loop; other site 640131011164 ATP binding site [chemical binding]; other site 640131011165 Q-loop/lid; other site 640131011166 ABC transporter signature motif; other site 640131011167 Walker B; other site 640131011168 D-loop; other site 640131011169 H-loop/switch region; other site 640131011170 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 640131011171 FtsX-like permease family; Region: FtsX; pfam02687 640131011172 macrolide transporter subunit MacA; Provisional; Region: PRK11578 640131011173 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131011174 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131011175 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 640131011176 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 640131011177 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 640131011178 putative active site [active] 640131011179 putative metal-binding site [ion binding]; other site 640131011180 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 640131011181 amphipathic channel; other site 640131011182 Asn-Pro-Ala signature motifs; other site 640131011183 Predicted membrane protein [Function unknown]; Region: COG2431 640131011184 hybrid cluster protein; Provisional; Region: PRK05290 640131011185 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131011186 ACS interaction site; other site 640131011187 CODH interaction site; other site 640131011188 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 640131011189 hybrid metal cluster; other site 640131011190 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 640131011191 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 640131011192 FAD binding pocket [chemical binding]; other site 640131011193 FAD binding motif [chemical binding]; other site 640131011194 phosphate binding motif [ion binding]; other site 640131011195 beta-alpha-beta structure motif; other site 640131011196 NAD binding pocket [chemical binding]; other site 640131011197 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131011198 catalytic loop [active] 640131011199 iron binding site [ion binding]; other site 640131011200 DoxX; Region: DoxX; pfam07681 640131011201 pyruvate dehydrogenase; Provisional; Region: PRK09124 640131011202 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 640131011203 PYR/PP interface [polypeptide binding]; other site 640131011204 dimer interface [polypeptide binding]; other site 640131011205 tetramer interface [polypeptide binding]; other site 640131011206 TPP binding site [chemical binding]; other site 640131011207 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131011208 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 640131011209 TPP-binding site [chemical binding]; other site 640131011210 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 640131011211 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 640131011212 tetramer interface [polypeptide binding]; other site 640131011213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131011214 catalytic residue [active] 640131011215 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 640131011216 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 640131011217 putative NAD(P) binding site [chemical binding]; other site 640131011218 putative active site [active] 640131011219 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 640131011220 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 640131011221 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131011222 NAD(P) binding site [chemical binding]; other site 640131011223 active site 640131011224 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 640131011225 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 640131011226 amidase catalytic site [active] 640131011227 Zn binding residues [ion binding]; other site 640131011228 substrate binding site [chemical binding]; other site 640131011229 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131011230 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131011231 metal binding site [ion binding]; metal-binding site 640131011232 active site 640131011233 I-site; other site 640131011234 hypothetical protein; Provisional; Region: PRK09929 640131011235 putative lipoprotein; Provisional; Region: PRK10533 640131011236 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 640131011237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011238 Walker A/P-loop; other site 640131011239 ATP binding site [chemical binding]; other site 640131011240 Q-loop/lid; other site 640131011241 ABC transporter signature motif; other site 640131011242 Walker B; other site 640131011243 D-loop; other site 640131011244 H-loop/switch region; other site 640131011245 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 640131011246 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131011247 substrate binding pocket [chemical binding]; other site 640131011248 membrane-bound complex binding site; other site 640131011249 hinge residues; other site 640131011250 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131011251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011252 dimer interface [polypeptide binding]; other site 640131011253 conserved gate region; other site 640131011254 putative PBP binding loops; other site 640131011255 ABC-ATPase subunit interface; other site 640131011256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011257 dimer interface [polypeptide binding]; other site 640131011258 conserved gate region; other site 640131011259 putative PBP binding loops; other site 640131011260 ABC-ATPase subunit interface; other site 640131011261 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 640131011262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131011263 substrate binding pocket [chemical binding]; other site 640131011264 membrane-bound complex binding site; other site 640131011265 hinge residues; other site 640131011266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131011267 dimer interface [polypeptide binding]; other site 640131011268 phosphorylation site [posttranslational modification] 640131011269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131011270 ATP binding site [chemical binding]; other site 640131011271 Mg2+ binding site [ion binding]; other site 640131011272 G-X-G motif; other site 640131011273 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 640131011274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131011275 active site 640131011276 phosphorylation site [posttranslational modification] 640131011277 intermolecular recognition site; other site 640131011278 dimerization interface [polypeptide binding]; other site 640131011279 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131011280 DNA binding site [nucleotide binding] 640131011281 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 640131011282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131011283 S-adenosylmethionine binding site [chemical binding]; other site 640131011284 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 640131011285 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131011286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011287 dimer interface [polypeptide binding]; other site 640131011288 conserved gate region; other site 640131011289 putative PBP binding loops; other site 640131011290 ABC-ATPase subunit interface; other site 640131011291 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 640131011292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011293 dimer interface [polypeptide binding]; other site 640131011294 conserved gate region; other site 640131011295 putative PBP binding loops; other site 640131011296 ABC-ATPase subunit interface; other site 640131011297 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 640131011298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011299 Walker A/P-loop; other site 640131011300 ATP binding site [chemical binding]; other site 640131011301 Q-loop/lid; other site 640131011302 ABC transporter signature motif; other site 640131011303 Walker B; other site 640131011304 D-loop; other site 640131011305 H-loop/switch region; other site 640131011306 TOBE domain; Region: TOBE_2; pfam08402 640131011307 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 640131011308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 640131011309 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 640131011310 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 640131011311 RimK-like ATP-grasp domain; Region: RimK; pfam08443 640131011312 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 640131011313 dimer interface [polypeptide binding]; other site 640131011314 FMN binding site [chemical binding]; other site 640131011315 NADPH bind site [chemical binding]; other site 640131011316 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 640131011317 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 640131011318 GSH binding site [chemical binding]; other site 640131011319 catalytic residues [active] 640131011320 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 640131011321 putative transporter; Provisional; Region: PRK04972 640131011322 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 640131011323 TrkA-C domain; Region: TrkA_C; pfam02080 640131011324 TrkA-C domain; Region: TrkA_C; pfam02080 640131011325 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 640131011326 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 640131011327 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131011328 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 640131011329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131011331 putative substrate translocation pore; other site 640131011332 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 640131011333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011334 active site 640131011335 motif I; other site 640131011336 motif II; other site 640131011337 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011338 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 640131011339 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 640131011340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011341 putative substrate translocation pore; other site 640131011342 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 640131011343 active site 640131011344 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 640131011345 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 640131011346 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131011347 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 640131011348 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 640131011349 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 640131011350 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 640131011351 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 640131011352 putative C-terminal domain interface [polypeptide binding]; other site 640131011353 putative GSH binding site (G-site) [chemical binding]; other site 640131011354 putative dimer interface [polypeptide binding]; other site 640131011355 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 640131011356 putative N-terminal domain interface [polypeptide binding]; other site 640131011357 putative dimer interface [polypeptide binding]; other site 640131011358 putative substrate binding pocket (H-site) [chemical binding]; other site 640131011359 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 640131011360 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 640131011361 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 640131011362 galactoside permease; Reviewed; Region: lacY; PRK09528 640131011363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011364 putative substrate translocation pore; other site 640131011365 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 640131011366 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 640131011367 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 640131011368 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131011369 FeS/SAM binding site; other site 640131011370 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 640131011371 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131011372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011373 dimer interface [polypeptide binding]; other site 640131011374 conserved gate region; other site 640131011375 putative PBP binding loops; other site 640131011376 ABC-ATPase subunit interface; other site 640131011377 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 640131011378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011379 dimer interface [polypeptide binding]; other site 640131011380 conserved gate region; other site 640131011381 putative PBP binding loops; other site 640131011382 ABC-ATPase subunit interface; other site 640131011383 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 640131011384 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 640131011385 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 640131011386 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131011387 Walker A/P-loop; other site 640131011388 ATP binding site [chemical binding]; other site 640131011389 Q-loop/lid; other site 640131011390 ABC transporter signature motif; other site 640131011391 Walker B; other site 640131011392 D-loop; other site 640131011393 H-loop/switch region; other site 640131011394 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131011395 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131011396 Walker A/P-loop; other site 640131011397 ATP binding site [chemical binding]; other site 640131011398 Q-loop/lid; other site 640131011399 ABC transporter signature motif; other site 640131011400 Walker B; other site 640131011401 D-loop; other site 640131011402 H-loop/switch region; other site 640131011403 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 640131011404 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 640131011405 catalytic nucleophile [active] 640131011406 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 640131011407 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 640131011408 dimer interface [polypeptide binding]; other site 640131011409 putative functional site; other site 640131011410 putative MPT binding site; other site 640131011411 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 640131011412 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 640131011413 ATP binding site [chemical binding]; other site 640131011414 substrate interface [chemical binding]; other site 640131011415 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 640131011416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131011417 FeS/SAM binding site; other site 640131011418 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 640131011419 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 640131011420 dimer interface [polypeptide binding]; other site 640131011421 active site 640131011422 glycine loop; other site 640131011423 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 640131011424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011425 active site 640131011426 motif I; other site 640131011427 motif II; other site 640131011428 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011429 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 640131011430 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131011431 DNA binding site [nucleotide binding] 640131011432 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131011433 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 640131011434 ligand binding site [chemical binding]; other site 640131011435 dimerization interface [polypeptide binding]; other site 640131011436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011437 D-galactonate transporter; Region: 2A0114; TIGR00893 640131011438 putative substrate translocation pore; other site 640131011439 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 640131011440 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 640131011441 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 640131011442 putative active site [active] 640131011443 putative catalytic site [active] 640131011444 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 640131011445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131011446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011447 Walker A/P-loop; other site 640131011448 ATP binding site [chemical binding]; other site 640131011449 Q-loop/lid; other site 640131011450 ABC transporter signature motif; other site 640131011451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131011452 Walker B; other site 640131011453 D-loop; other site 640131011454 ABC transporter; Region: ABC_tran_2; pfam12848 640131011455 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131011456 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 640131011457 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 640131011458 L,D-transpeptidase; Provisional; Region: PRK10260 640131011459 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 640131011460 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 640131011461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131011462 DNA-binding site [nucleotide binding]; DNA binding site 640131011463 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 640131011464 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 640131011465 beta-galactosidase; Region: BGL; TIGR03356 640131011466 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131011467 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131011468 active site 640131011469 catalytic tetrad [active] 640131011470 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 640131011471 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 640131011472 transmembrane helices; other site 640131011473 manganese transport regulator MntR; Provisional; Region: PRK11050 640131011474 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 640131011475 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 640131011476 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 640131011477 Sulfatase; Region: Sulfatase; pfam00884 640131011478 outer membrane protein X; Provisional; Region: ompX; PRK09408 640131011479 threonine and homoserine efflux system; Provisional; Region: PRK10532 640131011480 EamA-like transporter family; Region: EamA; pfam00892 640131011481 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 640131011482 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 640131011483 dimerization interface [polypeptide binding]; other site 640131011484 DPS ferroxidase diiron center [ion binding]; other site 640131011485 ion pore; other site 640131011486 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 640131011487 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131011488 substrate binding pocket [chemical binding]; other site 640131011489 membrane-bound complex binding site; other site 640131011490 hinge residues; other site 640131011491 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131011492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011493 dimer interface [polypeptide binding]; other site 640131011494 conserved gate region; other site 640131011495 putative PBP binding loops; other site 640131011496 ABC-ATPase subunit interface; other site 640131011497 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 640131011498 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131011499 Walker A/P-loop; other site 640131011500 ATP binding site [chemical binding]; other site 640131011501 Q-loop/lid; other site 640131011502 ABC transporter signature motif; other site 640131011503 Walker B; other site 640131011504 D-loop; other site 640131011505 H-loop/switch region; other site 640131011506 putative mechanosensitive channel protein; Provisional; Region: PRK11465 640131011507 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131011508 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 640131011509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131011510 S-adenosylmethionine binding site [chemical binding]; other site 640131011511 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 640131011512 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131011513 hypothetical protein; Provisional; Region: PRK11019 640131011514 Protein of unknown function (DUF1471); Region: DUF1471; cl11507 640131011515 glycosyl transferase family protein; Provisional; Region: PRK08136 640131011516 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 640131011517 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 640131011518 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 640131011519 DEAD_2; Region: DEAD_2; pfam06733 640131011520 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 640131011521 helicase 45; Provisional; Region: PTZ00424 640131011522 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 640131011523 ATP binding site [chemical binding]; other site 640131011524 Mg++ binding site [ion binding]; other site 640131011525 motif III; other site 640131011526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131011527 nucleotide binding region [chemical binding]; other site 640131011528 ATP-binding site [chemical binding]; other site 640131011529 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 640131011530 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 640131011531 PYR/PP interface [polypeptide binding]; other site 640131011532 dimer interface [polypeptide binding]; other site 640131011533 TPP binding site [chemical binding]; other site 640131011534 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131011535 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 640131011536 TPP-binding site [chemical binding]; other site 640131011537 dimer interface [polypeptide binding]; other site 640131011538 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 640131011539 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131011540 NAD(P) binding site [chemical binding]; other site 640131011541 active site 640131011542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011543 D-galactonate transporter; Region: 2A0114; TIGR00893 640131011544 putative substrate translocation pore; other site 640131011545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011546 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 640131011547 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131011548 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 640131011549 dimerization interface [polypeptide binding]; other site 640131011550 substrate binding pocket [chemical binding]; other site 640131011551 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 640131011552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131011553 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 640131011554 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 640131011555 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131011556 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131011557 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 640131011558 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 640131011559 Walker A/P-loop; other site 640131011560 ATP binding site [chemical binding]; other site 640131011561 Q-loop/lid; other site 640131011562 ABC transporter signature motif; other site 640131011563 Walker B; other site 640131011564 D-loop; other site 640131011565 H-loop/switch region; other site 640131011566 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 640131011567 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 640131011568 Walker A/P-loop; other site 640131011569 ATP binding site [chemical binding]; other site 640131011570 Q-loop/lid; other site 640131011571 ABC transporter signature motif; other site 640131011572 Walker B; other site 640131011573 D-loop; other site 640131011574 H-loop/switch region; other site 640131011575 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 640131011576 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 640131011577 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 640131011578 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 640131011579 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 640131011580 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 640131011581 putative catalytic site [active] 640131011582 putative metal binding site [ion binding]; other site 640131011583 putative phosphate binding site [ion binding]; other site 640131011584 cardiolipin synthase 2; Provisional; Region: PRK11263 640131011585 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 640131011586 putative active site [active] 640131011587 catalytic site [active] 640131011588 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 640131011589 putative active site [active] 640131011590 catalytic site [active] 640131011591 Predicted integral membrane protein [Function unknown]; Region: COG0392 640131011592 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 640131011593 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 640131011594 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 640131011595 MoaE homodimer interface [polypeptide binding]; other site 640131011596 MoaD interaction [polypeptide binding]; other site 640131011597 active site residues [active] 640131011598 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 640131011599 MoaE interaction surface [polypeptide binding]; other site 640131011600 MoeB interaction surface [polypeptide binding]; other site 640131011601 thiocarboxylated glycine; other site 640131011602 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 640131011603 trimer interface [polypeptide binding]; other site 640131011604 dimer interface [polypeptide binding]; other site 640131011605 putative active site [active] 640131011606 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 640131011607 MPT binding site; other site 640131011608 trimer interface [polypeptide binding]; other site 640131011609 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 640131011610 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131011611 FeS/SAM binding site; other site 640131011612 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 640131011613 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 640131011614 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 640131011615 phosphate binding site [ion binding]; other site 640131011616 putative substrate binding pocket [chemical binding]; other site 640131011617 dimer interface [polypeptide binding]; other site 640131011618 putative metal dependent hydrolase; Provisional; Region: PRK11598 640131011619 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 640131011620 Sulfatase; Region: Sulfatase; pfam00884 640131011621 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 640131011622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131011623 active site 640131011624 phosphorylation site [posttranslational modification] 640131011625 intermolecular recognition site; other site 640131011626 dimerization interface [polypeptide binding]; other site 640131011627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131011628 DNA binding site [nucleotide binding] 640131011629 sensor protein BasS/PmrB; Provisional; Region: PRK10755 640131011630 HAMP domain; Region: HAMP; pfam00672 640131011631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131011632 ATP binding site [chemical binding]; other site 640131011633 Mg2+ binding site [ion binding]; other site 640131011634 G-X-G motif; other site 640131011635 excinuclease ABC subunit B; Provisional; Region: PRK05298 640131011636 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131011637 ATP binding site [chemical binding]; other site 640131011638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131011639 nucleotide binding region [chemical binding]; other site 640131011640 ATP-binding site [chemical binding]; other site 640131011641 Ultra-violet resistance protein B; Region: UvrB; pfam12344 640131011642 UvrB/uvrC motif; Region: UVR; pfam02151 640131011643 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 640131011644 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 640131011645 Walker A/P-loop; other site 640131011646 ATP binding site [chemical binding]; other site 640131011647 Q-loop/lid; other site 640131011648 ABC transporter signature motif; other site 640131011649 Walker B; other site 640131011650 D-loop; other site 640131011651 H-loop/switch region; other site 640131011652 AAA domain; Region: AAA_26; pfam13500 640131011653 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 640131011654 active site 640131011655 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 640131011656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131011657 S-adenosylmethionine binding site [chemical binding]; other site 640131011658 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 640131011659 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 640131011660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131011661 catalytic residue [active] 640131011662 biotin synthase; Provisional; Region: PRK15108 640131011663 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131011664 FeS/SAM binding site; other site 640131011665 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 640131011666 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 640131011667 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131011668 inhibitor-cofactor binding pocket; inhibition site 640131011669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131011670 catalytic residue [active] 640131011671 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 640131011672 substrate binding site [chemical binding]; other site 640131011673 putative proline-specific permease; Provisional; Region: proY; PRK10580 640131011674 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 640131011675 active sites [active] 640131011676 tetramer interface [polypeptide binding]; other site 640131011677 urocanate hydratase; Provisional; Region: PRK05414 640131011678 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 640131011679 histidine utilization repressor; Provisional; Region: PRK14999 640131011680 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131011681 DNA-binding site [nucleotide binding]; DNA binding site 640131011682 UTRA domain; Region: UTRA; pfam07702 640131011683 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 640131011684 putative active site [active] 640131011685 putative metal binding site [ion binding]; other site 640131011686 imidazolonepropionase; Validated; Region: PRK09356 640131011687 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 640131011688 active site 640131011689 acyl-CoA thioesterase; Provisional; Region: PRK10531 640131011690 putative pectinesterase; Region: PLN02432; cl01911 640131011691 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 640131011692 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 640131011693 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131011694 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 640131011695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011696 motif I; other site 640131011697 motif II; other site 640131011698 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 640131011699 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131011700 Ligand Binding Site [chemical binding]; other site 640131011701 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 640131011702 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131011703 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 640131011704 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 640131011705 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 640131011706 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131011707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131011708 DNA binding residues [nucleotide binding] 640131011709 dimerization interface [polypeptide binding]; other site 640131011710 transcriptional regulator MirA; Provisional; Region: PRK15043 640131011711 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 640131011712 DNA binding residues [nucleotide binding] 640131011713 Sensors of blue-light using FAD; Region: BLUF; pfam04940 640131011714 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131011715 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 640131011716 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 640131011717 6-phosphogluconolactonase; Provisional; Region: PRK11028 640131011718 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 640131011719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011720 active site 640131011721 motif I; other site 640131011722 motif II; other site 640131011723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011724 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 640131011725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011726 Walker A/P-loop; other site 640131011727 ATP binding site [chemical binding]; other site 640131011728 Q-loop/lid; other site 640131011729 ABC transporter signature motif; other site 640131011730 Walker B; other site 640131011731 D-loop; other site 640131011732 H-loop/switch region; other site 640131011733 TOBE domain; Region: TOBE; cl01440 640131011734 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 640131011735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131011736 dimer interface [polypeptide binding]; other site 640131011737 conserved gate region; other site 640131011738 putative PBP binding loops; other site 640131011739 ABC-ATPase subunit interface; other site 640131011740 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 640131011741 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131011742 substrate binding pocket [chemical binding]; other site 640131011743 membrane-bound complex binding site; other site 640131011744 hinge residues; other site 640131011745 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 640131011746 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 640131011747 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 640131011748 molybdenum-pterin binding domain; Region: Mop; TIGR00638 640131011749 TOBE domain; Region: TOBE; pfam03459 640131011750 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 640131011751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011752 Walker A/P-loop; other site 640131011753 ATP binding site [chemical binding]; other site 640131011754 Q-loop/lid; other site 640131011755 ABC transporter signature motif; other site 640131011756 Walker B; other site 640131011757 D-loop; other site 640131011758 H-loop/switch region; other site 640131011759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131011760 Walker A/P-loop; other site 640131011761 ATP binding site [chemical binding]; other site 640131011762 Q-loop/lid; other site 640131011763 ABC transporter signature motif; other site 640131011764 Walker B; other site 640131011765 D-loop; other site 640131011766 H-loop/switch region; other site 640131011767 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 640131011768 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 640131011769 NAD binding site [chemical binding]; other site 640131011770 homodimer interface [polypeptide binding]; other site 640131011771 active site 640131011772 substrate binding site [chemical binding]; other site 640131011773 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 640131011774 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 640131011775 dimer interface [polypeptide binding]; other site 640131011776 active site 640131011777 galactokinase; Provisional; Region: PRK05101 640131011778 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 640131011779 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 640131011780 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 640131011781 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 640131011782 active site 640131011783 catalytic residues [active] 640131011784 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 640131011785 catalytic core [active] 640131011786 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 640131011787 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 640131011788 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 640131011789 YbgS-like protein; Region: YbgS; pfam13985 640131011790 zinc transporter ZitB; Provisional; Region: PRK03557 640131011791 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 640131011792 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 640131011793 quinolinate synthetase; Provisional; Region: PRK09375 640131011794 tol-pal system protein YbgF; Provisional; Region: PRK10803 640131011795 Tetratricopeptide repeat; Region: TPR_6; pfam13174 640131011796 Tetratricopeptide repeat; Region: TPR_6; pfam13174 640131011797 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 640131011798 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 640131011799 ligand binding site [chemical binding]; other site 640131011800 translocation protein TolB; Provisional; Region: tolB; PRK03629 640131011801 TolB amino-terminal domain; Region: TolB_N; pfam04052 640131011802 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 640131011803 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 640131011804 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 640131011805 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 640131011806 TolA C-terminal; Region: TolA; pfam06519 640131011807 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 640131011808 colicin uptake protein TolR; Provisional; Region: PRK11024 640131011809 colicin uptake protein TolQ; Provisional; Region: PRK10801 640131011810 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 640131011811 active site 640131011812 hypothetical protein; Provisional; Region: PRK10588 640131011813 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 640131011814 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 640131011815 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 640131011816 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 640131011817 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 640131011818 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 640131011819 CoA binding domain; Region: CoA_binding; smart00881 640131011820 CoA-ligase; Region: Ligase_CoA; pfam00549 640131011821 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 640131011822 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 640131011823 CoA-ligase; Region: Ligase_CoA; pfam00549 640131011824 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 640131011825 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 640131011826 E3 interaction surface; other site 640131011827 lipoyl attachment site [posttranslational modification]; other site 640131011828 e3 binding domain; Region: E3_binding; pfam02817 640131011829 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 640131011830 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 640131011831 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 640131011832 TPP-binding site [chemical binding]; other site 640131011833 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 640131011834 dimer interface [polypeptide binding]; other site 640131011835 PYR/PP interface [polypeptide binding]; other site 640131011836 TPP binding site [chemical binding]; other site 640131011837 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 640131011838 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 640131011839 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 640131011840 L-aspartate oxidase; Provisional; Region: PRK06175 640131011841 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 640131011842 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 640131011843 SdhC subunit interface [polypeptide binding]; other site 640131011844 proximal heme binding site [chemical binding]; other site 640131011845 cardiolipin binding site; other site 640131011846 Iron-sulfur protein interface; other site 640131011847 proximal quinone binding site [chemical binding]; other site 640131011848 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 640131011849 Iron-sulfur protein interface; other site 640131011850 proximal quinone binding site [chemical binding]; other site 640131011851 SdhD (CybS) interface [polypeptide binding]; other site 640131011852 proximal heme binding site [chemical binding]; other site 640131011853 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 640131011854 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 640131011855 dimer interface [polypeptide binding]; other site 640131011856 active site 640131011857 citrylCoA binding site [chemical binding]; other site 640131011858 NADH binding [chemical binding]; other site 640131011859 cationic pore residues; other site 640131011860 oxalacetate/citrate binding site [chemical binding]; other site 640131011861 coenzyme A binding site [chemical binding]; other site 640131011862 catalytic triad [active] 640131011863 endonuclease VIII; Provisional; Region: PRK10445 640131011864 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 640131011865 DNA binding site [nucleotide binding] 640131011866 catalytic residue [active] 640131011867 putative catalytic residues [active] 640131011868 H2TH interface [polypeptide binding]; other site 640131011869 intercalation triad [nucleotide binding]; other site 640131011870 substrate specificity determining residue; other site 640131011871 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 640131011872 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 640131011873 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 640131011874 putative substrate binding pocket [chemical binding]; other site 640131011875 AC domain interface; other site 640131011876 catalytic triad [active] 640131011877 AB domain interface; other site 640131011878 interchain disulfide; other site 640131011879 LamB/YcsF family protein; Provisional; Region: PRK05406 640131011880 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 640131011881 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 640131011882 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 640131011883 Uncharacterized conserved protein [Function unknown]; Region: COG0327 640131011884 metal-binding protein; Provisional; Region: PRK10799 640131011885 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 640131011886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011887 putative substrate translocation pore; other site 640131011888 POT family; Region: PTR2; pfam00854 640131011889 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 640131011890 DNA photolyase; Region: DNA_photolyase; pfam00875 640131011891 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 640131011892 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 640131011893 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 640131011894 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131011895 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 640131011896 sensor protein KdpD; Provisional; Region: PRK10490 640131011897 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 640131011898 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 640131011899 Ligand Binding Site [chemical binding]; other site 640131011900 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 640131011901 GAF domain; Region: GAF_3; pfam13492 640131011902 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131011903 dimer interface [polypeptide binding]; other site 640131011904 phosphorylation site [posttranslational modification] 640131011905 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131011906 ATP binding site [chemical binding]; other site 640131011907 Mg2+ binding site [ion binding]; other site 640131011908 G-X-G motif; other site 640131011909 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 640131011910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131011911 active site 640131011912 phosphorylation site [posttranslational modification] 640131011913 intermolecular recognition site; other site 640131011914 dimerization interface [polypeptide binding]; other site 640131011915 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131011916 DNA binding site [nucleotide binding] 640131011917 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 640131011918 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 640131011919 active site 640131011920 substrate binding site [chemical binding]; other site 640131011921 metal binding site [ion binding]; metal-binding site 640131011922 replication initiation regulator SeqA; Provisional; Region: PRK11187 640131011923 acyl-CoA esterase; Provisional; Region: PRK10673 640131011924 PGAP1-like protein; Region: PGAP1; pfam07819 640131011925 LexA regulated protein; Provisional; Region: PRK11675 640131011926 flavodoxin FldA; Validated; Region: PRK09267 640131011927 ferric uptake regulator; Provisional; Region: fur; PRK09462 640131011928 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 640131011929 metal binding site 2 [ion binding]; metal-binding site 640131011930 putative DNA binding helix; other site 640131011931 metal binding site 1 [ion binding]; metal-binding site 640131011932 dimer interface [polypeptide binding]; other site 640131011933 structural Zn2+ binding site [ion binding]; other site 640131011934 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 640131011935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131011936 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 640131011937 putative dimerization interface [polypeptide binding]; other site 640131011938 tricarballylate dehydrogenase; Validated; Region: PRK08274 640131011939 tricarballylate utilization protein B; Provisional; Region: PRK15033 640131011940 citrate-proton symporter; Provisional; Region: PRK15075 640131011941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131011942 putative substrate translocation pore; other site 640131011943 YbfN-like lipoprotein; Region: YbfN; pfam13982 640131011944 outer membrane porin, OprD family; Region: OprD; pfam03573 640131011945 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 640131011946 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 640131011947 active site 640131011948 HIGH motif; other site 640131011949 nucleotide binding site [chemical binding]; other site 640131011950 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 640131011951 KMSKS motif; other site 640131011952 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 640131011953 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 640131011954 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131011955 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131011956 active site turn [active] 640131011957 phosphorylation site [posttranslational modification] 640131011958 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 640131011959 HPr interaction site; other site 640131011960 glycerol kinase (GK) interaction site [polypeptide binding]; other site 640131011961 active site 640131011962 phosphorylation site [posttranslational modification] 640131011963 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 640131011964 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 640131011965 active site 640131011966 trimer interface [polypeptide binding]; other site 640131011967 allosteric site; other site 640131011968 active site lid [active] 640131011969 hexamer (dimer of trimers) interface [polypeptide binding]; other site 640131011970 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 640131011971 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 640131011972 active site 640131011973 dimer interface [polypeptide binding]; other site 640131011974 MarR family; Region: MarR; pfam01047 640131011975 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 640131011976 ROK family; Region: ROK; pfam00480 640131011977 UMP phosphatase; Provisional; Region: PRK10444 640131011978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011979 active site 640131011980 motif I; other site 640131011981 motif II; other site 640131011982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131011983 asparagine synthetase B; Provisional; Region: asnB; PRK09431 640131011984 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 640131011985 active site 640131011986 dimer interface [polypeptide binding]; other site 640131011987 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 640131011988 Ligand Binding Site [chemical binding]; other site 640131011989 Molecular Tunnel; other site 640131011990 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 640131011991 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 640131011992 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 640131011993 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 640131011994 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131011995 FeS/SAM binding site; other site 640131011996 TRAM domain; Region: TRAM; pfam01938 640131011997 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 640131011998 PhoH-like protein; Region: PhoH; pfam02562 640131011999 metal-binding heat shock protein; Provisional; Region: PRK00016 640131012000 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 640131012001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 640131012002 Transporter associated domain; Region: CorC_HlyC; smart01091 640131012003 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 640131012004 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 640131012005 putative active site [active] 640131012006 catalytic triad [active] 640131012007 putative dimer interface [polypeptide binding]; other site 640131012008 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 640131012009 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131012010 substrate binding pocket [chemical binding]; other site 640131012011 membrane-bound complex binding site; other site 640131012012 hinge residues; other site 640131012013 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131012014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012015 dimer interface [polypeptide binding]; other site 640131012016 conserved gate region; other site 640131012017 putative PBP binding loops; other site 640131012018 ABC-ATPase subunit interface; other site 640131012019 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131012020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012021 dimer interface [polypeptide binding]; other site 640131012022 conserved gate region; other site 640131012023 putative PBP binding loops; other site 640131012024 ABC-ATPase subunit interface; other site 640131012025 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131012026 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131012027 Walker A/P-loop; other site 640131012028 ATP binding site [chemical binding]; other site 640131012029 Q-loop/lid; other site 640131012030 ABC transporter signature motif; other site 640131012031 Walker B; other site 640131012032 D-loop; other site 640131012033 H-loop/switch region; other site 640131012034 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 640131012035 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 640131012036 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 640131012037 haemagglutination activity domain; Region: Haemagg_act; pfam05860 640131012038 hypothetical protein; Provisional; Region: PRK11032 640131012039 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 640131012040 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 640131012041 HIGH motif; other site 640131012042 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 640131012043 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 640131012044 active site 640131012045 KMSKS motif; other site 640131012046 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 640131012047 tRNA binding surface [nucleotide binding]; other site 640131012048 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 640131012049 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 640131012050 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 640131012051 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 640131012052 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 640131012053 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 640131012054 active site 640131012055 (T/H)XGH motif; other site 640131012056 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 640131012057 catalytic core [active] 640131012058 ribosome-associated protein; Provisional; Region: PRK11538 640131012059 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 640131012060 penicillin-binding protein 2; Provisional; Region: PRK10795 640131012061 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 640131012062 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 640131012063 cell wall shape-determining protein; Provisional; Region: PRK10794 640131012064 rare lipoprotein A; Provisional; Region: PRK10672 640131012065 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 640131012066 Sporulation related domain; Region: SPOR; pfam05036 640131012067 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 640131012068 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 640131012069 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 640131012070 hypothetical protein; Provisional; Region: PRK04998 640131012071 lipoate-protein ligase B; Provisional; Region: PRK14342 640131012072 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 640131012073 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131012074 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 640131012075 substrate binding pocket [chemical binding]; other site 640131012076 dimerization interface [polypeptide binding]; other site 640131012077 lipoyl synthase; Provisional; Region: PRK05481 640131012078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131012079 FeS/SAM binding site; other site 640131012080 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 640131012081 Predicted amidohydrolase [General function prediction only]; Region: COG0388 640131012082 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 640131012083 putative active site [active] 640131012084 catalytic triad [active] 640131012085 putative dimer interface [polypeptide binding]; other site 640131012086 chromosome condensation membrane protein; Provisional; Region: PRK14196 640131012087 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 640131012088 DNA-binding site [nucleotide binding]; DNA binding site 640131012089 RNA-binding motif; other site 640131012090 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 640131012091 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 640131012092 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 640131012093 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 640131012094 B1 nucleotide binding pocket [chemical binding]; other site 640131012095 B2 nucleotide binding pocket [chemical binding]; other site 640131012096 CAS motifs; other site 640131012097 active site 640131012098 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 640131012099 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 640131012100 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 640131012101 Ligand Binding Site [chemical binding]; other site 640131012102 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 640131012103 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 640131012104 catalytic residue [active] 640131012105 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 640131012106 catalytic residues [active] 640131012107 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131012108 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131012109 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 640131012110 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 640131012111 dimer interface [polypeptide binding]; other site 640131012112 decamer (pentamer of dimers) interface [polypeptide binding]; other site 640131012113 catalytic triad [active] 640131012114 peroxidatic and resolving cysteines [active] 640131012115 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 640131012116 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 640131012117 dimerization domain [polypeptide binding]; other site 640131012118 dimer interface [polypeptide binding]; other site 640131012119 catalytic residues [active] 640131012120 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 640131012121 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131012122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131012123 dimerization interface [polypeptide binding]; other site 640131012124 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 640131012125 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 640131012126 Active Sites [active] 640131012127 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 640131012128 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 640131012129 ParB-like nuclease domain; Region: ParBc; pfam02195 640131012130 methionine aminotransferase; Validated; Region: PRK09082 640131012131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131012132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012133 homodimer interface [polypeptide binding]; other site 640131012134 catalytic residue [active] 640131012135 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; Region: enolase-ppase; TIGR01691 640131012136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131012137 motif II; other site 640131012138 ARD/ARD' family; Region: ARD; pfam03079 640131012139 Cupin domain; Region: Cupin_2; cl17218 640131012140 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 640131012141 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 640131012142 molybdopterin cofactor binding site [chemical binding]; other site 640131012143 substrate binding site [chemical binding]; other site 640131012144 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 640131012145 molybdopterin cofactor binding site; other site 640131012146 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 640131012147 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 640131012148 putative ligand binding site [chemical binding]; other site 640131012149 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131012150 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131012151 Walker A/P-loop; other site 640131012152 ATP binding site [chemical binding]; other site 640131012153 Q-loop/lid; other site 640131012154 ABC transporter signature motif; other site 640131012155 Walker B; other site 640131012156 D-loop; other site 640131012157 H-loop/switch region; other site 640131012158 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131012159 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131012160 TM-ABC transporter signature motif; other site 640131012161 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131012162 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131012163 TM-ABC transporter signature motif; other site 640131012164 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131012165 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 640131012166 substrate binding site [chemical binding]; other site 640131012167 ATP binding site [chemical binding]; other site 640131012168 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 640131012169 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 640131012170 putative ligand binding site [chemical binding]; other site 640131012171 putative NAD binding site [chemical binding]; other site 640131012172 catalytic site [active] 640131012173 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 640131012174 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 640131012175 putative N- and C-terminal domain interface [polypeptide binding]; other site 640131012176 putative active site [active] 640131012177 MgATP binding site [chemical binding]; other site 640131012178 catalytic site [active] 640131012179 metal binding site [ion binding]; metal-binding site 640131012180 putative xylulose binding site [chemical binding]; other site 640131012181 methylthioribulose-1-phosphate dehydratase; Provisional; Region: PRK09220 640131012182 intersubunit interface [polypeptide binding]; other site 640131012183 active site 640131012184 Zn2+ binding site [ion binding]; other site 640131012185 cytosine permease; Provisional; Region: codB; PRK11017 640131012186 Na binding site [ion binding]; other site 640131012187 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 640131012188 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 640131012189 cytosine deaminase; Provisional; Region: PRK09230 640131012190 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 640131012191 active site 640131012192 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131012193 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131012194 DNA binding site [nucleotide binding] 640131012195 domain linker motif; other site 640131012196 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 640131012197 putative dimerization interface [polypeptide binding]; other site 640131012198 putative ligand binding site [chemical binding]; other site 640131012199 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 640131012200 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 640131012201 active site 640131012202 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 640131012203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012204 putative substrate translocation pore; other site 640131012205 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 640131012206 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 640131012207 catalytic core [active] 640131012208 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 640131012209 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 640131012210 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 640131012211 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 640131012212 Uncharacterized conserved protein [Function unknown]; Region: COG5276 640131012213 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 640131012214 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 640131012215 putative ligand binding site [chemical binding]; other site 640131012216 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131012217 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131012218 TM-ABC transporter signature motif; other site 640131012219 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131012220 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131012221 Walker A/P-loop; other site 640131012222 ATP binding site [chemical binding]; other site 640131012223 Q-loop/lid; other site 640131012224 ABC transporter signature motif; other site 640131012225 Walker B; other site 640131012226 D-loop; other site 640131012227 H-loop/switch region; other site 640131012228 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131012229 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 640131012230 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 640131012231 putative active site [active] 640131012232 metal binding site [ion binding]; metal-binding site 640131012233 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 640131012234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131012235 NAD(P) binding site [chemical binding]; other site 640131012236 active site 640131012237 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 640131012238 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131012239 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131012240 salt bridge; other site 640131012241 non-specific DNA binding site [nucleotide binding]; other site 640131012242 sequence-specific DNA binding site [nucleotide binding]; other site 640131012243 Uncharacterized small protein [Function unknown]; Region: COG2879 640131012244 carbon starvation protein A; Provisional; Region: PRK15015 640131012245 Carbon starvation protein CstA; Region: CstA; pfam02554 640131012246 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 640131012247 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 640131012248 CoenzymeA binding site [chemical binding]; other site 640131012249 subunit interaction site [polypeptide binding]; other site 640131012250 PHB binding site; other site 640131012251 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 640131012252 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 640131012253 putative NAD(P) binding site [chemical binding]; other site 640131012254 active site 640131012255 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 640131012256 hydrophobic substrate binding pocket; other site 640131012257 Isochorismatase family; Region: Isochorismatase; pfam00857 640131012258 active site 640131012259 conserved cis-peptide bond; other site 640131012260 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 640131012261 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 640131012262 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 640131012263 acyl-activating enzyme (AAE) consensus motif; other site 640131012264 active site 640131012265 AMP binding site [chemical binding]; other site 640131012266 substrate binding site [chemical binding]; other site 640131012267 isochorismate synthase EntC; Provisional; Region: PRK15016 640131012268 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 640131012269 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 640131012270 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 640131012271 siderophore binding site; other site 640131012272 enterobactin exporter EntS; Provisional; Region: PRK10489 640131012273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012274 putative substrate translocation pore; other site 640131012275 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131012276 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131012277 ABC-ATPase subunit interface; other site 640131012278 dimer interface [polypeptide binding]; other site 640131012279 putative PBP binding regions; other site 640131012280 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 640131012281 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131012282 ABC-ATPase subunit interface; other site 640131012283 dimer interface [polypeptide binding]; other site 640131012284 putative PBP binding regions; other site 640131012285 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 640131012286 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131012287 Walker A/P-loop; other site 640131012288 ATP binding site [chemical binding]; other site 640131012289 Q-loop/lid; other site 640131012290 ABC transporter signature motif; other site 640131012291 Walker B; other site 640131012292 D-loop; other site 640131012293 H-loop/switch region; other site 640131012294 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 640131012295 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 640131012296 acyl-activating enzyme (AAE) consensus motif; other site 640131012297 AMP binding site [chemical binding]; other site 640131012298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 640131012299 MbtH-like protein; Region: MbtH; cl01279 640131012300 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 640131012301 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 640131012302 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 640131012303 outer membrane receptor FepA; Provisional; Region: PRK13524 640131012304 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131012305 N-terminal plug; other site 640131012306 ligand-binding site [chemical binding]; other site 640131012307 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 640131012308 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 640131012309 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 640131012310 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 640131012311 PYR/PP interface [polypeptide binding]; other site 640131012312 dimer interface [polypeptide binding]; other site 640131012313 TPP binding site [chemical binding]; other site 640131012314 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131012315 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 640131012316 TPP-binding site [chemical binding]; other site 640131012317 dimer interface [polypeptide binding]; other site 640131012318 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 640131012319 MarR family; Region: MarR_2; cl17246 640131012320 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 640131012321 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 640131012322 bacterial glycerol kinase 2-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GK2_bacteria; cd07791 640131012323 N- and C-terminal domain interface [polypeptide binding]; other site 640131012324 active site 640131012325 MgATP binding site [chemical binding]; other site 640131012326 catalytic site [active] 640131012327 metal binding site [ion binding]; metal-binding site 640131012328 putative homotetramer interface [polypeptide binding]; other site 640131012329 putative homodimer interface [polypeptide binding]; other site 640131012330 glycerol binding site [chemical binding]; other site 640131012331 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 640131012332 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 640131012333 Predicted periplasmic lipoprotein (DUF2291); Region: DUF2291; cl02395 640131012334 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131012335 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131012336 Walker A/P-loop; other site 640131012337 ATP binding site [chemical binding]; other site 640131012338 Q-loop/lid; other site 640131012339 ABC transporter signature motif; other site 640131012340 Walker B; other site 640131012341 D-loop; other site 640131012342 H-loop/switch region; other site 640131012343 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131012344 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131012345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131012346 TM-ABC transporter signature motif; other site 640131012347 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 640131012348 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 640131012349 NAD binding site [chemical binding]; other site 640131012350 homotetramer interface [polypeptide binding]; other site 640131012351 homodimer interface [polypeptide binding]; other site 640131012352 active site 640131012353 substrate binding site [chemical binding]; other site 640131012354 short chain dehydrogenase; Provisional; Region: PRK06114 640131012355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131012356 NAD(P) binding site [chemical binding]; other site 640131012357 active site 640131012358 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 640131012359 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 640131012360 C-terminal domain interface [polypeptide binding]; other site 640131012361 GSH binding site (G-site) [chemical binding]; other site 640131012362 dimer interface [polypeptide binding]; other site 640131012363 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 640131012364 N-terminal domain interface [polypeptide binding]; other site 640131012365 dimer interface [polypeptide binding]; other site 640131012366 substrate binding pocket (H-site) [chemical binding]; other site 640131012367 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 640131012368 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131012369 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 640131012370 dimerization interface [polypeptide binding]; other site 640131012371 substrate binding pocket [chemical binding]; other site 640131012372 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 640131012373 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131012374 C-lysozyme inhibitor; Provisional; Region: PRK09993 640131012375 choline transport protein BetT; Provisional; Region: PRK09928 640131012376 transcriptional regulator BetI; Validated; Region: PRK00767 640131012377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131012378 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 640131012379 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 640131012380 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 640131012381 tetrameric interface [polypeptide binding]; other site 640131012382 NAD binding site [chemical binding]; other site 640131012383 catalytic residues [active] 640131012384 choline dehydrogenase; Validated; Region: PRK02106 640131012385 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 640131012386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 640131012387 YheO-like PAS domain; Region: PAS_6; pfam08348 640131012388 HTH domain; Region: HTH_22; pfam13309 640131012389 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 640131012390 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 640131012391 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 640131012392 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 640131012393 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 640131012394 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 640131012395 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 640131012396 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131012397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012398 dimer interface [polypeptide binding]; other site 640131012399 conserved gate region; other site 640131012400 putative PBP binding loops; other site 640131012401 ABC-ATPase subunit interface; other site 640131012402 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 640131012403 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 640131012404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012405 dimer interface [polypeptide binding]; other site 640131012406 conserved gate region; other site 640131012407 ABC-ATPase subunit interface; other site 640131012408 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 640131012409 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131012410 Walker A/P-loop; other site 640131012411 ATP binding site [chemical binding]; other site 640131012412 Q-loop/lid; other site 640131012413 ABC transporter signature motif; other site 640131012414 Walker B; other site 640131012415 D-loop; other site 640131012416 H-loop/switch region; other site 640131012417 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 640131012418 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131012419 Walker A/P-loop; other site 640131012420 ATP binding site [chemical binding]; other site 640131012421 Q-loop/lid; other site 640131012422 ABC transporter signature motif; other site 640131012423 Walker B; other site 640131012424 D-loop; other site 640131012425 H-loop/switch region; other site 640131012426 hypothetical protein; Provisional; Region: PRK06062 640131012427 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131012428 inhibitor-cofactor binding pocket; inhibition site 640131012429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012430 catalytic residue [active] 640131012431 malonic semialdehyde reductase; Provisional; Region: PRK10538 640131012432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131012433 NAD(P) binding site [chemical binding]; other site 640131012434 active site 640131012435 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131012436 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131012437 Walker A/P-loop; other site 640131012438 ATP binding site [chemical binding]; other site 640131012439 Q-loop/lid; other site 640131012440 ABC transporter signature motif; other site 640131012441 Walker B; other site 640131012442 D-loop; other site 640131012443 H-loop/switch region; other site 640131012444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012445 dimer interface [polypeptide binding]; other site 640131012446 conserved gate region; other site 640131012447 putative PBP binding loops; other site 640131012448 ABC-ATPase subunit interface; other site 640131012449 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 640131012450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012451 dimer interface [polypeptide binding]; other site 640131012452 conserved gate region; other site 640131012453 putative PBP binding loops; other site 640131012454 ABC-ATPase subunit interface; other site 640131012455 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131012456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131012457 substrate binding pocket [chemical binding]; other site 640131012458 membrane-bound complex binding site; other site 640131012459 hinge residues; other site 640131012460 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131012461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131012462 DNA-binding site [nucleotide binding]; DNA binding site 640131012463 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131012464 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012465 homodimer interface [polypeptide binding]; other site 640131012466 catalytic residue [active] 640131012467 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131012468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131012469 DNA-binding site [nucleotide binding]; DNA binding site 640131012470 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131012471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012472 homodimer interface [polypeptide binding]; other site 640131012473 catalytic residue [active] 640131012474 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 640131012475 EamA-like transporter family; Region: EamA; pfam00892 640131012476 allantoate amidohydrolase; Reviewed; Region: PRK12893 640131012477 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 640131012478 active site 640131012479 metal binding site [ion binding]; metal-binding site 640131012480 dimer interface [polypeptide binding]; other site 640131012481 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 640131012482 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131012483 Walker A/P-loop; other site 640131012484 ATP binding site [chemical binding]; other site 640131012485 Q-loop/lid; other site 640131012486 ABC transporter signature motif; other site 640131012487 Walker B; other site 640131012488 D-loop; other site 640131012489 H-loop/switch region; other site 640131012490 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131012491 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 640131012492 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131012493 Walker A/P-loop; other site 640131012494 ATP binding site [chemical binding]; other site 640131012495 Q-loop/lid; other site 640131012496 ABC transporter signature motif; other site 640131012497 Walker B; other site 640131012498 D-loop; other site 640131012499 H-loop/switch region; other site 640131012500 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 640131012501 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 640131012502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 640131012503 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 640131012504 Protein of unknown function (DUF419); Region: DUF419; cl15265 640131012505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012506 dimer interface [polypeptide binding]; other site 640131012507 conserved gate region; other site 640131012508 putative PBP binding loops; other site 640131012509 ABC-ATPase subunit interface; other site 640131012510 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_8; cd08495 640131012511 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 640131012512 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 640131012513 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 640131012514 Predicted periplasmic protein [Function unknown]; Region: COG3698 640131012515 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 640131012516 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 640131012517 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 640131012518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131012519 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131012520 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 640131012521 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 640131012522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131012523 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 640131012524 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 640131012525 Soluble P-type ATPase [General function prediction only]; Region: COG4087 640131012526 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 640131012527 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 640131012528 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 640131012529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131012530 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 640131012531 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 640131012532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131012533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131012534 hypothetical protein; Provisional; Region: PRK10250 640131012535 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 640131012536 dimer interface [polypeptide binding]; other site 640131012537 FMN binding site [chemical binding]; other site 640131012538 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131012539 non-specific DNA binding site [nucleotide binding]; other site 640131012540 salt bridge; other site 640131012541 sequence-specific DNA binding site [nucleotide binding]; other site 640131012542 Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973 640131012543 Helix-turn-helix domain; Region: HTH_31; pfam13560 640131012544 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 640131012545 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012546 putative substrate translocation pore; other site 640131012547 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 640131012548 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131012549 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131012550 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131012551 DNA binding site [nucleotide binding] 640131012552 domain linker motif; other site 640131012553 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 640131012554 dimerization interface [polypeptide binding]; other site 640131012555 ligand binding site [chemical binding]; other site 640131012556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131012557 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131012558 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131012559 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 640131012560 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 640131012561 Metal-binding active site; metal-binding site 640131012562 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 640131012563 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 640131012564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012565 putative substrate translocation pore; other site 640131012566 phenylalanine transporter; Provisional; Region: PRK10249 640131012567 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 640131012568 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131012569 N-terminal plug; other site 640131012570 ligand-binding site [chemical binding]; other site 640131012571 PQQ-like domain; Region: PQQ_2; pfam13360 640131012572 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 640131012573 active site 640131012574 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 640131012575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 640131012576 NAD(P) binding site [chemical binding]; other site 640131012577 catalytic residues [active] 640131012578 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 640131012579 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 640131012580 Predicted enzyme of the cupin superfamily [General function prediction only]; Region: COG3450 640131012581 Amino acid permease; Region: AA_permease_2; pfam13520 640131012582 Protein of unknown function (DUF3156); Region: DUF3156; pfam11354 640131012583 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131012584 non-specific DNA binding site [nucleotide binding]; other site 640131012585 salt bridge; other site 640131012586 sequence-specific DNA binding site [nucleotide binding]; other site 640131012587 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907 640131012588 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996 640131012589 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 640131012590 active site 640131012591 Zn binding site [ion binding]; other site 640131012592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012593 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131012594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131012595 DNA binding residues [nucleotide binding] 640131012596 dimerization interface [polypeptide binding]; other site 640131012597 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 640131012598 classical (c) SDRs; Region: SDR_c; cd05233 640131012599 NAD(P) binding site [chemical binding]; other site 640131012600 active site 640131012601 Molybdenum cofactor biosynthesis protein F; Region: MoaF; pfam10703 640131012602 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131012603 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131012604 active site 640131012605 catalytic tetrad [active] 640131012606 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 640131012607 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131012608 substrate binding pocket [chemical binding]; other site 640131012609 membrane-bound complex binding site; other site 640131012610 hinge residues; other site 640131012611 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131012612 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 640131012613 metal binding site [ion binding]; metal-binding site 640131012614 putative dimer interface [polypeptide binding]; other site 640131012615 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 640131012616 Domain of unknown function (DUF3315); Region: DUF3315; pfam11776 640131012617 ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048 640131012618 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 640131012619 intersubunit interface [polypeptide binding]; other site 640131012620 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131012621 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131012622 ABC-ATPase subunit interface; other site 640131012623 dimer interface [polypeptide binding]; other site 640131012624 putative PBP binding regions; other site 640131012625 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 640131012626 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131012627 Walker A/P-loop; other site 640131012628 ATP binding site [chemical binding]; other site 640131012629 Q-loop/lid; other site 640131012630 ABC transporter signature motif; other site 640131012631 Walker B; other site 640131012632 D-loop; other site 640131012633 H-loop/switch region; other site 640131012634 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 640131012635 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131012636 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131012637 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 640131012638 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 640131012639 Transcriptional regulator; Region: Rrf2; cl17282 640131012640 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131012641 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 640131012642 putative substrate binding site [chemical binding]; other site 640131012643 putative ATP binding site [chemical binding]; other site 640131012644 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131012645 trimer interface; other site 640131012646 sugar binding site [chemical binding]; other site 640131012647 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 640131012648 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131012649 active site turn [active] 640131012650 phosphorylation site [posttranslational modification] 640131012651 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131012652 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 640131012653 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 640131012654 substrate binding [chemical binding]; other site 640131012655 active site 640131012656 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 640131012657 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 640131012658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131012659 DNA binding site [nucleotide binding] 640131012660 domain linker motif; other site 640131012661 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 640131012662 dimerization interface [polypeptide binding]; other site 640131012663 ligand binding site [chemical binding]; other site 640131012664 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131012665 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131012666 TM-ABC transporter signature motif; other site 640131012667 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131012668 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131012669 Walker A/P-loop; other site 640131012670 ATP binding site [chemical binding]; other site 640131012671 Q-loop/lid; other site 640131012672 ABC transporter signature motif; other site 640131012673 Walker B; other site 640131012674 D-loop; other site 640131012675 H-loop/switch region; other site 640131012676 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131012677 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 640131012678 Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301 640131012679 putative ligand binding site [chemical binding]; other site 640131012680 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 640131012681 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131012682 DNA binding site [nucleotide binding] 640131012683 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 640131012684 putative ligand binding site [chemical binding]; other site 640131012685 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131012686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131012687 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131012688 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131012689 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131012690 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131012691 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131012692 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 640131012693 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 640131012694 Metal-binding active site; metal-binding site 640131012695 TolA C-terminal; Region: TolA; pfam06519 640131012696 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 640131012697 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 640131012698 dimer interface [polypeptide binding]; other site 640131012699 putative anticodon binding site; other site 640131012700 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 640131012701 motif 1; other site 640131012702 active site 640131012703 motif 2; other site 640131012704 motif 3; other site 640131012705 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 640131012706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012707 putative substrate translocation pore; other site 640131012708 POT family; Region: PTR2; pfam00854 640131012709 lysine decarboxylase CadA; Provisional; Region: PRK15400 640131012710 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 640131012711 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 640131012712 homodimer interface [polypeptide binding]; other site 640131012713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012714 catalytic residue [active] 640131012715 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 640131012716 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 640131012717 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 640131012718 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 640131012719 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131012720 DNA binding site [nucleotide binding] 640131012721 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131012722 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 640131012723 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 640131012724 putative acyl-acceptor binding pocket; other site 640131012725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131012726 Coenzyme A binding pocket [chemical binding]; other site 640131012727 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131012728 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131012729 PapC N-terminal domain; Region: PapC_N; pfam13954 640131012730 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131012731 PapC C-terminal domain; Region: PapC_C; pfam13953 640131012732 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131012733 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131012734 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131012735 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131012736 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 640131012737 DNA binding residues [nucleotide binding] 640131012738 dimerization interface [polypeptide binding]; other site 640131012739 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 640131012740 dimer interface [polypeptide binding]; other site 640131012741 Citrate synthase; Region: Citrate_synt; pfam00285 640131012742 active site 640131012743 citrylCoA binding site [chemical binding]; other site 640131012744 NADH binding [chemical binding]; other site 640131012745 cationic pore residues; other site 640131012746 oxalacetate/citrate binding site [chemical binding]; other site 640131012747 coenzyme A binding site [chemical binding]; other site 640131012748 catalytic triad [active] 640131012749 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 640131012750 active site 640131012751 homotetramer interface [polypeptide binding]; other site 640131012752 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 640131012753 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 640131012754 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 640131012755 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 640131012756 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 640131012757 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 640131012758 homodimer interface [polypeptide binding]; other site 640131012759 NADP binding site [chemical binding]; other site 640131012760 substrate binding site [chemical binding]; other site 640131012761 ribosome-associated protein; Provisional; Region: PRK11507 640131012762 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 640131012763 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 640131012764 active site 640131012765 HIGH motif; other site 640131012766 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 640131012767 KMSKS motif; other site 640131012768 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 640131012769 tRNA binding surface [nucleotide binding]; other site 640131012770 anticodon binding site; other site 640131012771 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 640131012772 substrate binding site [chemical binding]; other site 640131012773 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 640131012774 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 640131012775 putative active site [active] 640131012776 putative metal binding site [ion binding]; other site 640131012777 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 640131012778 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 640131012779 ATP-grasp domain; Region: ATP-grasp; pfam02222 640131012780 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 640131012781 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 640131012782 active site residue [active] 640131012783 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 640131012784 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 640131012785 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 640131012786 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 640131012787 Q-loop/lid; other site 640131012788 ABC transporter signature motif; other site 640131012789 Walker B; other site 640131012790 D-loop; other site 640131012791 H-loop/switch region; other site 640131012792 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 640131012793 active site 640131012794 catalytic triad [active] 640131012795 oxyanion hole [active] 640131012796 switch loop; other site 640131012797 oxidoreductase; Provisional; Region: PRK08017 640131012798 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 640131012799 NADP binding site [chemical binding]; other site 640131012800 active site 640131012801 steroid binding site; other site 640131012802 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 640131012803 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 640131012804 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 640131012805 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 640131012806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131012807 Walker A/P-loop; other site 640131012808 ATP binding site [chemical binding]; other site 640131012809 Q-loop/lid; other site 640131012810 ABC transporter signature motif; other site 640131012811 Walker B; other site 640131012812 D-loop; other site 640131012813 H-loop/switch region; other site 640131012814 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 640131012815 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 640131012816 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 640131012817 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 640131012818 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 640131012819 DNA binding residues [nucleotide binding] 640131012820 dimer interface [polypeptide binding]; other site 640131012821 copper binding site [ion binding]; other site 640131012822 copper exporting ATPase; Provisional; Region: copA; PRK10671 640131012823 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 640131012824 metal-binding site [ion binding] 640131012825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 640131012826 metal-binding site [ion binding] 640131012827 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131012828 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131012829 motif II; other site 640131012830 TraB family; Region: TraB; cl12050 640131012831 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 640131012832 putative deacylase active site [active] 640131012833 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 640131012834 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 640131012835 active site 640131012836 metal binding site [ion binding]; metal-binding site 640131012837 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 640131012838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131012839 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131012840 putative substrate translocation pore; other site 640131012841 putative cation:proton antiport protein; Provisional; Region: PRK10669 640131012842 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 640131012843 TrkA-N domain; Region: TrkA_N; pfam02254 640131012844 inosine/guanosine kinase; Provisional; Region: PRK15074 640131012845 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131012846 ferrochelatase; Reviewed; Region: hemH; PRK00035 640131012847 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 640131012848 C-terminal domain interface [polypeptide binding]; other site 640131012849 active site 640131012850 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 640131012851 active site 640131012852 N-terminal domain interface [polypeptide binding]; other site 640131012853 adenylate kinase; Reviewed; Region: adk; PRK00279 640131012854 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 640131012855 AMP-binding site [chemical binding]; other site 640131012856 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 640131012857 heat shock protein 90; Provisional; Region: PRK05218 640131012858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131012859 ATP binding site [chemical binding]; other site 640131012860 Mg2+ binding site [ion binding]; other site 640131012861 G-X-G motif; other site 640131012862 recombination protein RecR; Reviewed; Region: recR; PRK00076 640131012863 RecR protein; Region: RecR; pfam02132 640131012864 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 640131012865 putative active site [active] 640131012866 putative metal-binding site [ion binding]; other site 640131012867 tetramer interface [polypeptide binding]; other site 640131012868 hypothetical protein; Validated; Region: PRK00153 640131012869 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14961 640131012870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131012871 Walker A motif; other site 640131012872 ATP binding site [chemical binding]; other site 640131012873 Walker B motif; other site 640131012874 arginine finger; other site 640131012875 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 640131012876 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 640131012877 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 640131012878 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131012879 active site 640131012880 hypothetical protein; Provisional; Region: PRK10527 640131012881 primosomal replication protein N''; Provisional; Region: PRK10093 640131012882 hypothetical protein; Provisional; Region: PRK11038 640131012883 putative transposase; Provisional; Region: PRK09857 640131012884 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 640131012885 hypothetical protein; Provisional; Region: PRK11281 640131012886 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 640131012887 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 640131012888 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 640131012889 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131012890 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 640131012891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131012892 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 640131012893 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 640131012894 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131012895 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 640131012896 Protein export membrane protein; Region: SecD_SecF; cl14618 640131012897 Hha toxicity attenuator; Provisional; Region: PRK10667 640131012898 gene expression modulator; Provisional; Region: PRK10945 640131012899 maltose O-acetyltransferase; Provisional; Region: PRK10092 640131012900 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 640131012901 active site 640131012902 substrate binding site [chemical binding]; other site 640131012903 trimer interface [polypeptide binding]; other site 640131012904 CoA binding site [chemical binding]; other site 640131012905 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 640131012906 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131012907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131012908 DNA-binding site [nucleotide binding]; DNA binding site 640131012909 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131012910 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012911 homodimer interface [polypeptide binding]; other site 640131012912 catalytic residue [active] 640131012913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 640131012914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131012915 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 640131012916 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 640131012917 lac repressor; Reviewed; Region: lacI; PRK09526 640131012918 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131012919 DNA binding site [nucleotide binding] 640131012920 domain linker motif; other site 640131012921 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 640131012922 ligand binding site [chemical binding]; other site 640131012923 dimerization interface (open form) [polypeptide binding]; other site 640131012924 dimerization interface (closed form) [polypeptide binding]; other site 640131012925 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131012926 trimer interface; other site 640131012927 sugar binding site [chemical binding]; other site 640131012928 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131012929 active site turn [active] 640131012930 phosphorylation site [posttranslational modification] 640131012931 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 640131012932 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 640131012933 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 640131012934 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 640131012935 Arabinogalactan endo-1,4-beta-galactosidase [Carbohydrate transport and metabolism]; Region: COG3867 640131012936 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131012937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012938 dimer interface [polypeptide binding]; other site 640131012939 conserved gate region; other site 640131012940 putative PBP binding loops; other site 640131012941 ABC-ATPase subunit interface; other site 640131012942 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131012943 dimer interface [polypeptide binding]; other site 640131012944 conserved gate region; other site 640131012945 ABC-ATPase subunit interface; other site 640131012946 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 640131012947 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 640131012948 DAK2 domain; Region: Dak2; cl03685 640131012949 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 640131012950 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131012951 Walker A/P-loop; other site 640131012952 ATP binding site [chemical binding]; other site 640131012953 Q-loop/lid; other site 640131012954 ABC transporter signature motif; other site 640131012955 Walker B; other site 640131012956 D-loop; other site 640131012957 H-loop/switch region; other site 640131012958 TOBE domain; Region: TOBE_2; pfam08402 640131012959 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 640131012960 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 640131012961 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131012962 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 640131012963 putative metal binding site [ion binding]; other site 640131012964 putative homodimer interface [polypeptide binding]; other site 640131012965 putative homotetramer interface [polypeptide binding]; other site 640131012966 putative homodimer-homodimer interface [polypeptide binding]; other site 640131012967 putative allosteric switch controlling residues; other site 640131012968 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 640131012969 Predicted membrane protein [Function unknown]; Region: COG2364 640131012970 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 640131012971 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 640131012972 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131012973 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131012974 DNA-binding site [nucleotide binding]; DNA binding site 640131012975 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131012976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131012977 homodimer interface [polypeptide binding]; other site 640131012978 catalytic residue [active] 640131012979 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 640131012980 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 640131012981 DNA binding site [nucleotide binding] 640131012982 active site 640131012983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 640131012984 acyl-CoA thioesterase II; Provisional; Region: PRK10526 640131012985 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 640131012986 active site 640131012987 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 640131012988 catalytic triad [active] 640131012989 dimer interface [polypeptide binding]; other site 640131012990 ammonium transporter; Provisional; Region: PRK10666 640131012991 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 640131012992 Nitrogen regulatory protein P-II; Region: P-II; smart00938 640131012993 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 640131012994 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 640131012995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131012996 Walker A/P-loop; other site 640131012997 ATP binding site [chemical binding]; other site 640131012998 Q-loop/lid; other site 640131012999 ABC transporter signature motif; other site 640131013000 Walker B; other site 640131013001 D-loop; other site 640131013002 H-loop/switch region; other site 640131013003 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 640131013004 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 640131013005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131013006 Walker A/P-loop; other site 640131013007 ATP binding site [chemical binding]; other site 640131013008 Q-loop/lid; other site 640131013009 ABC transporter signature motif; other site 640131013010 Walker B; other site 640131013011 D-loop; other site 640131013012 H-loop/switch region; other site 640131013013 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 640131013014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131013015 putative DNA binding site [nucleotide binding]; other site 640131013016 putative Zn2+ binding site [ion binding]; other site 640131013017 AsnC family; Region: AsnC_trans_reg; pfam01037 640131013018 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 640131013019 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 640131013020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131013021 catalytic residue [active] 640131013022 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 640131013023 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131013024 active site 640131013025 motif I; other site 640131013026 motif II; other site 640131013027 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 640131013028 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 640131013029 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 640131013030 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 640131013031 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 640131013032 Ligand Binding Site [chemical binding]; other site 640131013033 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 640131013034 active site 640131013035 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 640131013036 periplasmic folding chaperone; Provisional; Region: PRK10788 640131013037 SurA N-terminal domain; Region: SurA_N_3; cl07813 640131013038 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 640131013039 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 640131013040 IHF dimer interface [polypeptide binding]; other site 640131013041 IHF - DNA interface [nucleotide binding]; other site 640131013042 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 640131013043 Found in ATP-dependent protease La (LON); Region: LON; smart00464 640131013044 Found in ATP-dependent protease La (LON); Region: LON; smart00464 640131013045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131013046 Walker A motif; other site 640131013047 ATP binding site [chemical binding]; other site 640131013048 Walker B motif; other site 640131013049 arginine finger; other site 640131013050 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 640131013051 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 640131013052 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 640131013053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131013054 Walker A motif; other site 640131013055 ATP binding site [chemical binding]; other site 640131013056 Walker B motif; other site 640131013057 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 640131013058 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 640131013059 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 640131013060 oligomer interface [polypeptide binding]; other site 640131013061 active site residues [active] 640131013062 trigger factor; Provisional; Region: tig; PRK01490 640131013063 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 640131013064 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 640131013065 transcriptional regulator BolA; Provisional; Region: PRK11628 640131013066 hypothetical protein; Provisional; Region: PRK11627 640131013067 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 640131013068 muropeptide transporter; Reviewed; Region: ampG; PRK11902 640131013069 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131013070 putative substrate translocation pore; other site 640131013071 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 640131013072 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 640131013073 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 640131013074 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 640131013075 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 640131013076 D-pathway; other site 640131013077 Putative ubiquinol binding site [chemical binding]; other site 640131013078 Low-spin heme (heme b) binding site [chemical binding]; other site 640131013079 Putative water exit pathway; other site 640131013080 Binuclear center (heme o3/CuB) [ion binding]; other site 640131013081 K-pathway; other site 640131013082 Putative proton exit pathway; other site 640131013083 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 640131013084 Subunit I/III interface [polypeptide binding]; other site 640131013085 Subunit III/IV interface [polypeptide binding]; other site 640131013086 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 640131013087 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 640131013088 UbiA prenyltransferase family; Region: UbiA; pfam01040 640131013089 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 640131013090 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131013091 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131013092 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 640131013093 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 640131013094 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 640131013095 shikimate binding site; other site 640131013096 NAD(P) binding site [chemical binding]; other site 640131013097 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12843 640131013098 NIPSNAP; Region: NIPSNAP; pfam07978 640131013099 putative FAD-binding dehydrogenase; Reviewed; Region: PRK06134 640131013100 Predicted oxidoreductase [General function prediction only]; Region: COG3573 640131013101 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 640131013102 benzoate transport; Region: 2A0115; TIGR00895 640131013103 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131013104 putative substrate translocation pore; other site 640131013105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131013106 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131013107 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131013108 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131013109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131013110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131013111 putative substrate translocation pore; other site 640131013112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 640131013113 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 640131013114 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 640131013115 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 640131013116 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 640131013117 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 640131013118 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 640131013119 conserved cys residue [active] 640131013120 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_3; cd08896 640131013121 putative hydrophobic ligand binding site [chemical binding]; other site 640131013122 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 640131013123 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 640131013124 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 640131013125 Ligand Binding Site [chemical binding]; other site 640131013126 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 640131013127 active site residue [active] 640131013128 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 640131013129 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 640131013130 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 640131013131 substrate binding pocket [chemical binding]; other site 640131013132 chain length determination region; other site 640131013133 substrate-Mg2+ binding site; other site 640131013134 catalytic residues [active] 640131013135 aspartate-rich region 1; other site 640131013136 active site lid residues [active] 640131013137 aspartate-rich region 2; other site 640131013138 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 640131013139 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 640131013140 TPP-binding site; other site 640131013141 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 640131013142 PYR/PP interface [polypeptide binding]; other site 640131013143 dimer interface [polypeptide binding]; other site 640131013144 TPP binding site [chemical binding]; other site 640131013145 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131013146 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131013147 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131013148 active site 640131013149 catalytic tetrad [active] 640131013150 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 640131013151 tetramer interfaces [polypeptide binding]; other site 640131013152 binuclear metal-binding site [ion binding]; other site 640131013153 thiamine monophosphate kinase; Provisional; Region: PRK05731 640131013154 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 640131013155 ATP binding site [chemical binding]; other site 640131013156 dimerization interface [polypeptide binding]; other site 640131013157 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 640131013158 putative RNA binding site [nucleotide binding]; other site 640131013159 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 640131013160 homopentamer interface [polypeptide binding]; other site 640131013161 active site 640131013162 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 640131013163 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 640131013164 catalytic motif [active] 640131013165 Zn binding site [ion binding]; other site 640131013166 RibD C-terminal domain; Region: RibD_C; cl17279 640131013167 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 640131013168 ATP cone domain; Region: ATP-cone; pfam03477 640131013169 hypothetical protein; Provisional; Region: PRK11530 640131013170 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 640131013171 Predicted transcriptional regulator [Transcription]; Region: COG2378 640131013172 HTH domain; Region: HTH_11; pfam08279 640131013173 WYL domain; Region: WYL; pfam13280 640131013174 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 640131013175 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131013176 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 640131013177 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 640131013178 Protein export membrane protein; Region: SecD_SecF; pfam02355 640131013179 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 640131013180 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 640131013181 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 640131013182 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 640131013183 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 640131013184 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 640131013185 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 640131013186 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 640131013187 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 640131013188 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 640131013189 peroxidase; Provisional; Region: PRK15000 640131013190 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 640131013191 dimer interface [polypeptide binding]; other site 640131013192 decamer (pentamer of dimers) interface [polypeptide binding]; other site 640131013193 catalytic triad [active] 640131013194 peroxidatic and resolving cysteines [active] 640131013195 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131013196 active site 640131013197 phosphorylation site [posttranslational modification] 640131013198 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 640131013199 active site 640131013200 P-loop; other site 640131013201 phosphorylation site [posttranslational modification] 640131013202 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 640131013203 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131013204 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 640131013205 substrate binding site [chemical binding]; other site 640131013206 ATP binding site [chemical binding]; other site 640131013207 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 640131013208 intersubunit interface [polypeptide binding]; other site 640131013209 active site 640131013210 zinc binding site [ion binding]; other site 640131013211 Na+ binding site [ion binding]; other site 640131013212 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 640131013213 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 640131013214 active site 640131013215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224 640131013216 Isochorismatase family; Region: Isochorismatase; pfam00857 640131013217 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 640131013218 catalytic triad [active] 640131013219 dimer interface [polypeptide binding]; other site 640131013220 conserved cis-peptide bond; other site 640131013221 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131013222 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 640131013223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 640131013224 dimerization interface [polypeptide binding]; other site 640131013225 maltodextrin glucosidase; Provisional; Region: PRK10785 640131013226 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 640131013227 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 640131013228 active site 640131013229 homodimer interface [polypeptide binding]; other site 640131013230 catalytic site [active] 640131013231 putative proline-specific permease; Provisional; Region: proY; PRK10580 640131013232 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 640131013233 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 640131013234 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 640131013235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131013236 putative active site [active] 640131013237 heme pocket [chemical binding]; other site 640131013238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131013239 dimer interface [polypeptide binding]; other site 640131013240 phosphorylation site [posttranslational modification] 640131013241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131013242 ATP binding site [chemical binding]; other site 640131013243 Mg2+ binding site [ion binding]; other site 640131013244 G-X-G motif; other site 640131013245 transcriptional regulator PhoB; Provisional; Region: PRK10161 640131013246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131013247 active site 640131013248 phosphorylation site [posttranslational modification] 640131013249 intermolecular recognition site; other site 640131013250 dimerization interface [polypeptide binding]; other site 640131013251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131013252 DNA binding site [nucleotide binding] 640131013253 exonuclease subunit SbcD; Provisional; Region: PRK10966 640131013254 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 640131013255 active site 640131013256 metal binding site [ion binding]; metal-binding site 640131013257 DNA binding site [nucleotide binding] 640131013258 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 640131013259 exonuclease subunit SbcC; Provisional; Region: PRK10246 640131013260 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131013261 Walker A/P-loop; other site 640131013262 ATP binding site [chemical binding]; other site 640131013263 Q-loop/lid; other site 640131013264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131013265 ABC transporter signature motif; other site 640131013266 Walker B; other site 640131013267 D-loop; other site 640131013268 H-loop/switch region; other site 640131013269 fructokinase; Reviewed; Region: PRK09557 640131013270 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131013271 nucleotide binding site [chemical binding]; other site 640131013272 Acetokinase family; Region: Acetate_kinase; cl17229 640131013273 recombination associated protein; Reviewed; Region: rdgC; PRK00321 640131013274 hypothetical protein; Provisional; Region: PRK10579 640131013275 hypothetical protein; Provisional; Region: PRK10481 640131013276 hypothetical protein; Provisional; Region: PRK10380 640131013277 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 640131013278 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 640131013279 ADP binding site [chemical binding]; other site 640131013280 magnesium binding site [ion binding]; other site 640131013281 putative shikimate binding site; other site 640131013282 Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849 640131013283 hypothetical protein; Validated; Region: PRK00124 640131013284 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 640131013285 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 640131013286 hypothetical protein; Provisional; Region: PRK11505 640131013287 psiF repeat; Region: PsiF_repeat; pfam07769 640131013288 psiF repeat; Region: PsiF_repeat; pfam07769 640131013289 alkaline phosphatase; Provisional; Region: PRK10518 640131013290 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 640131013291 active site 640131013292 dimer interface [polypeptide binding]; other site 640131013293 Sigma-S stabilisation anti-adaptor protein; Region: Anti-adapt_IraP; pfam10796 640131013294 drug efflux system protein MdtG; Provisional; Region: PRK09874 640131013295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131013296 putative substrate translocation pore; other site 640131013297 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 640131013298 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 640131013299 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 640131013300 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 640131013301 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 640131013302 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 640131013303 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 640131013304 microcin B17 transporter; Reviewed; Region: PRK11098 640131013305 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 640131013306 Isochorismatase family; Region: Isochorismatase; pfam00857 640131013307 catalytic triad [active] 640131013308 conserved cis-peptide bond; other site 640131013309 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 640131013310 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 640131013311 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 640131013312 dimer interface [polypeptide binding]; other site 640131013313 active site 640131013314 Schiff base residues; other site 640131013315 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 640131013316 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 640131013317 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 640131013318 putative acyl-acceptor binding pocket; other site 640131013319 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 640131013320 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 640131013321 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 640131013322 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 640131013323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013324 dimer interface [polypeptide binding]; other site 640131013325 conserved gate region; other site 640131013326 putative PBP binding loops; other site 640131013327 ABC-ATPase subunit interface; other site 640131013328 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 640131013329 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 640131013330 Walker A/P-loop; other site 640131013331 ATP binding site [chemical binding]; other site 640131013332 Q-loop/lid; other site 640131013333 ABC transporter signature motif; other site 640131013334 Walker B; other site 640131013335 D-loop; other site 640131013336 H-loop/switch region; other site 640131013337 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 640131013338 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131013339 substrate binding pocket [chemical binding]; other site 640131013340 membrane-bound complex binding site; other site 640131013341 hinge residues; other site 640131013342 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 640131013343 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 640131013344 S-methylmethionine transporter; Provisional; Region: PRK11387 640131013345 ethanolamine permease; Region: 2A0305; TIGR00908 640131013346 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 640131013347 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 640131013348 ethanolamine ammonia-lyase small subunit; Provisional; Region: PRK05465 640131013349 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 640131013350 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 640131013351 putative ligand binding site [chemical binding]; other site 640131013352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131013353 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 640131013354 TM-ABC transporter signature motif; other site 640131013355 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 640131013356 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 640131013357 TM-ABC transporter signature motif; other site 640131013358 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 640131013359 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 640131013360 Walker A/P-loop; other site 640131013361 ATP binding site [chemical binding]; other site 640131013362 Q-loop/lid; other site 640131013363 ABC transporter signature motif; other site 640131013364 Walker B; other site 640131013365 D-loop; other site 640131013366 H-loop/switch region; other site 640131013367 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 640131013368 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 640131013369 Walker A/P-loop; other site 640131013370 ATP binding site [chemical binding]; other site 640131013371 Q-loop/lid; other site 640131013372 ABC transporter signature motif; other site 640131013373 Walker B; other site 640131013374 D-loop; other site 640131013375 H-loop/switch region; other site 640131013376 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131013377 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131013378 substrate binding pocket [chemical binding]; other site 640131013379 membrane-bound complex binding site; other site 640131013380 hinge residues; other site 640131013381 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131013382 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131013383 Walker A/P-loop; other site 640131013384 ATP binding site [chemical binding]; other site 640131013385 Q-loop/lid; other site 640131013386 ABC transporter signature motif; other site 640131013387 Walker B; other site 640131013388 D-loop; other site 640131013389 H-loop/switch region; other site 640131013390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013391 dimer interface [polypeptide binding]; other site 640131013392 conserved gate region; other site 640131013393 putative PBP binding loops; other site 640131013394 ABC-ATPase subunit interface; other site 640131013395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013396 dimer interface [polypeptide binding]; other site 640131013397 conserved gate region; other site 640131013398 putative PBP binding loops; other site 640131013399 ABC-ATPase subunit interface; other site 640131013400 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131013401 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131013402 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 640131013403 putative fimbrial protein TcfA; Provisional; Region: PRK15308 640131013404 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131013405 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131013406 DNA binding residues [nucleotide binding] 640131013407 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 640131013408 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 640131013409 Walker A/P-loop; other site 640131013410 ATP binding site [chemical binding]; other site 640131013411 Q-loop/lid; other site 640131013412 ABC transporter signature motif; other site 640131013413 Walker B; other site 640131013414 D-loop; other site 640131013415 H-loop/switch region; other site 640131013416 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 640131013417 Transferrin; Region: Transferrin; cl02460 640131013418 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 640131013419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013420 dimer interface [polypeptide binding]; other site 640131013421 conserved gate region; other site 640131013422 putative PBP binding loops; other site 640131013423 ABC-ATPase subunit interface; other site 640131013424 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 640131013425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 640131013426 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 640131013427 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 640131013428 EamA-like transporter family; Region: EamA; pfam00892 640131013429 NlpC/P60 family; Region: NLPC_P60; pfam00877 640131013430 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 640131013431 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 640131013432 trimer interface [polypeptide binding]; other site 640131013433 eyelet of channel; other site 640131013434 gamma-glutamyl kinase; Provisional; Region: PRK05429 640131013435 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 640131013436 nucleotide binding site [chemical binding]; other site 640131013437 homotetrameric interface [polypeptide binding]; other site 640131013438 putative phosphate binding site [ion binding]; other site 640131013439 putative allosteric binding site; other site 640131013440 PUA domain; Region: PUA; pfam01472 640131013441 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 640131013442 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 640131013443 putative catalytic cysteine [active] 640131013444 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 640131013445 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 640131013446 Walker A/P-loop; other site 640131013447 ATP binding site [chemical binding]; other site 640131013448 Q-loop/lid; other site 640131013449 ABC transporter signature motif; other site 640131013450 Walker B; other site 640131013451 D-loop; other site 640131013452 H-loop/switch region; other site 640131013453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013454 dimer interface [polypeptide binding]; other site 640131013455 conserved gate region; other site 640131013456 putative PBP binding loops; other site 640131013457 ABC-ATPase subunit interface; other site 640131013458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013459 dimer interface [polypeptide binding]; other site 640131013460 conserved gate region; other site 640131013461 putative PBP binding loops; other site 640131013462 ABC-ATPase subunit interface; other site 640131013463 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 640131013464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131013465 NAD(P) binding site [chemical binding]; other site 640131013466 active site 640131013467 acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531 640131013468 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 640131013469 carboxyltransferase (CT) interaction site; other site 640131013470 biotinylation site [posttranslational modification]; other site 640131013471 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 640131013472 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131013473 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 640131013474 putative dimerization interface [polypeptide binding]; other site 640131013475 aspartate aminotransferase; Provisional; Region: PRK05764 640131013476 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131013477 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131013478 homodimer interface [polypeptide binding]; other site 640131013479 catalytic residue [active] 640131013480 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 640131013481 putative active site [active] 640131013482 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 640131013483 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 640131013484 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 640131013485 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131013486 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131013487 substrate binding pocket [chemical binding]; other site 640131013488 membrane-bound complex binding site; other site 640131013489 hinge residues; other site 640131013490 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 640131013491 EamA-like transporter family; Region: EamA; pfam00892 640131013492 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 640131013493 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 640131013494 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 640131013495 NAD(P) binding site [chemical binding]; other site 640131013496 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 640131013497 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 640131013498 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 640131013499 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 640131013500 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 640131013501 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 640131013502 carboxyltransferase (CT) interaction site; other site 640131013503 biotinylation site [posttranslational modification]; other site 640131013504 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 640131013505 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131013506 DNA binding residues [nucleotide binding] 640131013507 dimerization interface [polypeptide binding]; other site 640131013508 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 640131013509 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 640131013510 tetramer interface [polypeptide binding]; other site 640131013511 TPP-binding site [chemical binding]; other site 640131013512 heterodimer interface [polypeptide binding]; other site 640131013513 phosphorylation loop region [posttranslational modification] 640131013514 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 640131013515 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 640131013516 alpha subunit interface [polypeptide binding]; other site 640131013517 TPP binding site [chemical binding]; other site 640131013518 heterodimer interface [polypeptide binding]; other site 640131013519 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 640131013520 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 640131013521 E3 interaction surface; other site 640131013522 lipoyl attachment site [posttranslational modification]; other site 640131013523 e3 binding domain; Region: E3_binding; pfam02817 640131013524 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 640131013525 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 640131013526 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 640131013527 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 640131013528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131013529 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 640131013530 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 640131013531 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 640131013532 active site 640131013533 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 640131013534 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 640131013535 putative C-terminal domain interface [polypeptide binding]; other site 640131013536 putative GSH binding site (G-site) [chemical binding]; other site 640131013537 putative dimer interface [polypeptide binding]; other site 640131013538 C-terminal, alpha helical domain of an unknown subfamily 2 of Glutathione S-transferases; Region: GST_C_2; cd03180 640131013539 putative N-terminal domain interface [polypeptide binding]; other site 640131013540 putative dimer interface [polypeptide binding]; other site 640131013541 putative substrate binding pocket (H-site) [chemical binding]; other site 640131013542 Methyltransferase domain; Region: Methyltransf_31; pfam13847 640131013543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131013544 S-adenosylmethionine binding site [chemical binding]; other site 640131013545 hypothetical protein; Provisional; Region: PRK13687 640131013546 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 640131013547 substrate binding pocket [chemical binding]; other site 640131013548 active site 640131013549 iron coordination sites [ion binding]; other site 640131013550 Predicted dehydrogenase [General function prediction only]; Region: COG0579 640131013551 hydroxyglutarate oxidase; Provisional; Region: PRK11728 640131013552 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 640131013553 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 640131013554 tetramerization interface [polypeptide binding]; other site 640131013555 NAD(P) binding site [chemical binding]; other site 640131013556 catalytic residues [active] 640131013557 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 640131013558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131013559 inhibitor-cofactor binding pocket; inhibition site 640131013560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131013561 catalytic residue [active] 640131013562 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 640131013563 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 640131013564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131013565 DNA-binding site [nucleotide binding]; DNA binding site 640131013566 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 640131013567 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 640131013568 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 640131013569 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131013570 active site 640131013571 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 640131013572 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 640131013573 metal binding site [ion binding]; metal-binding site 640131013574 dimer interface [polypeptide binding]; other site 640131013575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131013576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131013577 Coenzyme A binding pocket [chemical binding]; other site 640131013578 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 640131013579 active site 640131013580 DNA polymerase IV; Validated; Region: PRK02406 640131013581 DNA binding site [nucleotide binding] 640131013582 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 640131013583 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 640131013584 active site 640131013585 catalytic site [active] 640131013586 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991 640131013587 Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464 640131013588 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 640131013589 catalytic loop [active] 640131013590 iron binding site [ion binding]; other site 640131013591 Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188 640131013592 FAD binding pocket [chemical binding]; other site 640131013593 FAD binding motif [chemical binding]; other site 640131013594 phosphate binding motif [ion binding]; other site 640131013595 beta-alpha-beta structure motif; other site 640131013596 NAD binding pocket [chemical binding]; other site 640131013597 Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830 640131013598 Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292 640131013599 Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346 640131013600 NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938 640131013601 Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349 640131013602 Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352 640131013603 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 640131013604 E3 interaction surface; other site 640131013605 lipoyl attachment site [posttranslational modification]; other site 640131013606 NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973 640131013607 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 640131013608 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 640131013609 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 640131013610 putative active site [active] 640131013611 putative dimer interface [polypeptide binding]; other site 640131013612 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 640131013613 dimer interface [polypeptide binding]; other site 640131013614 active site 640131013615 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 640131013616 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 640131013617 active site 640131013618 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 640131013619 C-N hydrolase family amidase; Provisional; Region: PRK10438 640131013620 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 640131013621 putative active site [active] 640131013622 catalytic triad [active] 640131013623 dimer interface [polypeptide binding]; other site 640131013624 multimer interface [polypeptide binding]; other site 640131013625 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 640131013626 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 640131013627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131013628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131013629 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 640131013630 dimerization interface [polypeptide binding]; other site 640131013631 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 640131013632 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 640131013633 active site 640131013634 catalytic site [active] 640131013635 substrate binding site [chemical binding]; other site 640131013636 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 640131013637 RNA/DNA hybrid binding site [nucleotide binding]; other site 640131013638 active site 640131013639 Methyltransferase domain; Region: Methyltransf_11; pfam08241 640131013640 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 640131013641 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 640131013642 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131013643 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131013644 catalytic residue [active] 640131013645 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131013646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 640131013647 hypothetical protein; Provisional; Region: PRK08317 640131013648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131013649 S-adenosylmethionine binding site [chemical binding]; other site 640131013650 hypothetical protein; Provisional; Region: PRK05421 640131013651 putative catalytic site [active] 640131013652 putative metal binding site [ion binding]; other site 640131013653 putative phosphate binding site [ion binding]; other site 640131013654 putative catalytic site [active] 640131013655 putative phosphate binding site [ion binding]; other site 640131013656 putative metal binding site [ion binding]; other site 640131013657 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 640131013658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131013659 putative substrate translocation pore; other site 640131013660 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131013661 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131013662 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 640131013663 putative effector binding pocket; other site 640131013664 dimerization interface [polypeptide binding]; other site 640131013665 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 640131013666 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 640131013667 active site 640131013668 catalytic tetrad [active] 640131013669 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 640131013670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131013671 active site 640131013672 motif I; other site 640131013673 motif II; other site 640131013674 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 640131013675 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 640131013676 Walker A/P-loop; other site 640131013677 ATP binding site [chemical binding]; other site 640131013678 Q-loop/lid; other site 640131013679 ABC transporter signature motif; other site 640131013680 Walker B; other site 640131013681 D-loop; other site 640131013682 H-loop/switch region; other site 640131013683 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 640131013684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131013685 dimer interface [polypeptide binding]; other site 640131013686 conserved gate region; other site 640131013687 ABC-ATPase subunit interface; other site 640131013688 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 640131013689 lipoprotein, YaeC family; Region: TIGR00363 640131013690 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 640131013691 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 640131013692 homodimer interaction site [polypeptide binding]; other site 640131013693 cofactor binding site; other site 640131013694 prolyl-tRNA synthetase; Provisional; Region: PRK09194 640131013695 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 640131013696 dimer interface [polypeptide binding]; other site 640131013697 motif 1; other site 640131013698 active site 640131013699 motif 2; other site 640131013700 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 640131013701 putative deacylase active site [active] 640131013702 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 640131013703 active site 640131013704 motif 3; other site 640131013705 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 640131013706 anticodon binding site; other site 640131013707 hypothetical protein; Provisional; Region: PRK11479 640131013708 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 640131013709 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 640131013710 NlpE N-terminal domain; Region: NlpE; pfam04170 640131013711 hypothetical protein; Provisional; Region: PRK09256 640131013712 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 640131013713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 640131013714 hypothetical protein; Provisional; Region: PRK04964 640131013715 Rho-binding antiterminator; Provisional; Region: PRK11625 640131013716 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 640131013717 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 640131013718 Ligand Binding Site [chemical binding]; other site 640131013719 TilS substrate binding domain; Region: TilS; pfam09179 640131013720 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 640131013721 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 640131013722 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131013723 putative metal binding site [ion binding]; other site 640131013724 lysine decarboxylase LdcC; Provisional; Region: PRK15399 640131013725 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 640131013726 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 640131013727 homodimer interface [polypeptide binding]; other site 640131013728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131013729 catalytic residue [active] 640131013730 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 640131013731 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 640131013732 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 640131013733 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 640131013734 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 640131013735 putative active site [active] 640131013736 putative PHP Thumb interface [polypeptide binding]; other site 640131013737 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 640131013738 generic binding surface II; other site 640131013739 generic binding surface I; other site 640131013740 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 640131013741 RNA/DNA hybrid binding site [nucleotide binding]; other site 640131013742 active site 640131013743 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 640131013744 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 640131013745 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 640131013746 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 640131013747 active site 640131013748 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 640131013749 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 640131013750 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 640131013751 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 640131013752 trimer interface [polypeptide binding]; other site 640131013753 active site 640131013754 UDP-GlcNAc binding site [chemical binding]; other site 640131013755 lipid binding site [chemical binding]; lipid-binding site 640131013756 periplasmic chaperone; Provisional; Region: PRK10780 640131013757 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 640131013758 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 640131013759 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131013760 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131013761 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131013762 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131013763 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131013764 Surface antigen; Region: Bac_surface_Ag; pfam01103 640131013765 zinc metallopeptidase RseP; Provisional; Region: PRK10779 640131013766 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 640131013767 active site 640131013768 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 640131013769 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 640131013770 protein binding site [polypeptide binding]; other site 640131013771 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 640131013772 putative substrate binding region [chemical binding]; other site 640131013773 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 640131013774 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 640131013775 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 640131013776 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 640131013777 catalytic residue [active] 640131013778 putative FPP diphosphate binding site; other site 640131013779 putative FPP binding hydrophobic cleft; other site 640131013780 dimer interface [polypeptide binding]; other site 640131013781 putative IPP diphosphate binding site; other site 640131013782 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 640131013783 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 640131013784 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 640131013785 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 640131013786 ribosome recycling factor; Reviewed; Region: frr; PRK00083 640131013787 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 640131013788 hinge region; other site 640131013789 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 640131013790 putative nucleotide binding site [chemical binding]; other site 640131013791 uridine monophosphate binding site [chemical binding]; other site 640131013792 homohexameric interface [polypeptide binding]; other site 640131013793 elongation factor Ts; Provisional; Region: tsf; PRK09377 640131013794 UBA/TS-N domain; Region: UBA; pfam00627 640131013795 Elongation factor TS; Region: EF_TS; pfam00889 640131013796 Elongation factor TS; Region: EF_TS; pfam00889 640131013797 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 640131013798 rRNA interaction site [nucleotide binding]; other site 640131013799 S8 interaction site; other site 640131013800 putative laminin-1 binding site; other site 640131013801 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 640131013802 active site 640131013803 PII uridylyl-transferase; Provisional; Region: PRK05007 640131013804 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 640131013805 metal binding triad; other site 640131013806 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 640131013807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131013808 Zn2+ binding site [ion binding]; other site 640131013809 Mg2+ binding site [ion binding]; other site 640131013810 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 640131013811 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 640131013812 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 640131013813 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 640131013814 trimer interface [polypeptide binding]; other site 640131013815 active site 640131013816 substrate binding site [chemical binding]; other site 640131013817 CoA binding site [chemical binding]; other site 640131013818 hypothetical protein; Provisional; Region: PRK13677 640131013819 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 640131013820 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 640131013821 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 640131013822 serine endoprotease; Provisional; Region: PRK10942 640131013823 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 640131013824 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 640131013825 protein binding site [polypeptide binding]; other site 640131013826 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 640131013827 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 640131013828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 640131013829 Zn2+ binding site [ion binding]; other site 640131013830 Mg2+ binding site [ion binding]; other site 640131013831 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 640131013832 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 640131013833 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 640131013834 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 640131013835 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 640131013836 cobalamin binding residues [chemical binding]; other site 640131013837 putative BtuC binding residues; other site 640131013838 dimer interface [polypeptide binding]; other site 640131013839 hypothetical protein; Provisional; Region: PRK10578 640131013840 UPF0126 domain; Region: UPF0126; pfam03458 640131013841 UPF0126 domain; Region: UPF0126; pfam03458 640131013842 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 640131013843 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 640131013844 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 640131013845 Cl- selectivity filter; other site 640131013846 Cl- binding residues [ion binding]; other site 640131013847 pore gating glutamate residue; other site 640131013848 dimer interface [polypeptide binding]; other site 640131013849 H+/Cl- coupling transport residue; other site 640131013850 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 640131013851 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 640131013852 inhibitor-cofactor binding pocket; inhibition site 640131013853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131013854 catalytic residue [active] 640131013855 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 640131013856 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131013857 ABC-ATPase subunit interface; other site 640131013858 dimer interface [polypeptide binding]; other site 640131013859 putative PBP binding regions; other site 640131013860 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 640131013861 ABC-ATPase subunit interface; other site 640131013862 dimer interface [polypeptide binding]; other site 640131013863 putative PBP binding regions; other site 640131013864 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 640131013865 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 640131013866 siderophore binding site; other site 640131013867 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 640131013868 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 640131013869 Walker A/P-loop; other site 640131013870 ATP binding site [chemical binding]; other site 640131013871 Q-loop/lid; other site 640131013872 ABC transporter signature motif; other site 640131013873 Walker B; other site 640131013874 D-loop; other site 640131013875 H-loop/switch region; other site 640131013876 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 640131013877 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131013878 N-terminal plug; other site 640131013879 ligand-binding site [chemical binding]; other site 640131013880 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 640131013881 Transglycosylase; Region: Transgly; pfam00912 640131013882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 640131013883 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 640131013884 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 640131013885 carbohydrate binding site [chemical binding]; other site 640131013886 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 640131013887 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 640131013888 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 640131013889 Ca binding site [ion binding]; other site 640131013890 active site 640131013891 catalytic site [active] 640131013892 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 640131013893 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 640131013894 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 640131013895 type II secretion system protein D; Region: type_II_gspD; TIGR02517 640131013896 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 640131013897 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 640131013898 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 640131013899 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 640131013900 type II secretion system protein E; Region: type_II_gspE; TIGR02533 640131013901 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 640131013902 Walker A motif; other site 640131013903 ATP binding site [chemical binding]; other site 640131013904 Walker B motif; other site 640131013905 type II secretion system protein F; Region: GspF; TIGR02120 640131013906 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 640131013907 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 640131013908 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 640131013909 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 640131013910 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 640131013911 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 640131013912 type II secretion system protein I; Region: gspI; TIGR01707 640131013913 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 640131013914 type II secretion system protein J; Region: gspJ; TIGR01711 640131013915 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 640131013916 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 640131013917 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 640131013918 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 640131013919 GspL periplasmic domain; Region: GspL_C; pfam12693 640131013920 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 640131013921 Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203 640131013922 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 640131013923 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 640131013924 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 640131013925 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 640131013926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131013927 ATP binding site [chemical binding]; other site 640131013928 putative Mg++ binding site [ion binding]; other site 640131013929 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131013930 nucleotide binding region [chemical binding]; other site 640131013931 ATP-binding site [chemical binding]; other site 640131013932 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 640131013933 2'-5' RNA ligase; Provisional; Region: PRK15124 640131013934 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 640131013935 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 640131013936 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 640131013937 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 640131013938 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 640131013939 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 640131013940 active site 640131013941 nucleotide binding site [chemical binding]; other site 640131013942 HIGH motif; other site 640131013943 KMSKS motif; other site 640131013944 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 640131013945 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 640131013946 active site 640131013947 NTP binding site [chemical binding]; other site 640131013948 metal binding triad [ion binding]; metal-binding site 640131013949 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 640131013950 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 640131013951 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 640131013952 catalytic center binding site [active] 640131013953 ATP binding site [chemical binding]; other site 640131013954 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 640131013955 oligomerization interface [polypeptide binding]; other site 640131013956 active site 640131013957 metal binding site [ion binding]; metal-binding site 640131013958 pantoate--beta-alanine ligase; Region: panC; TIGR00018 640131013959 Pantoate-beta-alanine ligase; Region: PanC; cd00560 640131013960 active site 640131013961 ATP-binding site [chemical binding]; other site 640131013962 pantoate-binding site; other site 640131013963 HXXH motif; other site 640131013964 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 640131013965 tetramerization interface [polypeptide binding]; other site 640131013966 active site 640131013967 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 640131013968 putative active site [active] 640131013969 putative metal binding site [ion binding]; other site 640131013970 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 640131013971 active pocket/dimerization site; other site 640131013972 active site 640131013973 phosphorylation site [posttranslational modification] 640131013974 inner membrane transport permease; Provisional; Region: PRK15066 640131013975 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 640131013976 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 640131013977 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 640131013978 Walker A/P-loop; other site 640131013979 ATP binding site [chemical binding]; other site 640131013980 Q-loop/lid; other site 640131013981 ABC transporter signature motif; other site 640131013982 Walker B; other site 640131013983 D-loop; other site 640131013984 H-loop/switch region; other site 640131013985 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 640131013986 active site clefts [active] 640131013987 zinc binding site [ion binding]; other site 640131013988 dimer interface [polypeptide binding]; other site 640131013989 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 640131013990 active site 640131013991 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 640131013992 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 640131013993 Trp docking motif [polypeptide binding]; other site 640131013994 putative active site [active] 640131013995 multicopper oxidase; Provisional; Region: PRK10965 640131013996 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 640131013997 Multicopper oxidase; Region: Cu-oxidase; pfam00394 640131013998 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 640131013999 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 640131014000 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 640131014001 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 640131014002 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 640131014003 spermidine synthase; Provisional; Region: PRK00811 640131014004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131014005 S-adenosylmethionine binding site [chemical binding]; other site 640131014006 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 640131014007 hypothetical protein; Provisional; Region: PRK05248 640131014008 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 640131014009 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 640131014010 substrate binding site [chemical binding]; other site 640131014011 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 640131014012 substrate binding site [chemical binding]; other site 640131014013 ligand binding site [chemical binding]; other site 640131014014 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 640131014015 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 640131014016 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 640131014017 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 640131014018 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131014019 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 640131014020 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 640131014021 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 640131014022 E3 interaction surface; other site 640131014023 lipoyl attachment site [posttranslational modification]; other site 640131014024 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 640131014025 E3 interaction surface; other site 640131014026 lipoyl attachment site [posttranslational modification]; other site 640131014027 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 640131014028 E3 interaction surface; other site 640131014029 lipoyl attachment site [posttranslational modification]; other site 640131014030 e3 binding domain; Region: E3_binding; pfam02817 640131014031 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 640131014032 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 640131014033 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 640131014034 dimer interface [polypeptide binding]; other site 640131014035 TPP-binding site [chemical binding]; other site 640131014036 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 640131014037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131014038 DNA-binding site [nucleotide binding]; DNA binding site 640131014039 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 640131014040 aromatic amino acid transporter; Provisional; Region: PRK10238 640131014041 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 640131014042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014043 putative substrate translocation pore; other site 640131014044 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 640131014045 active site 640131014046 regulatory protein AmpE; Provisional; Region: PRK10987 640131014047 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 640131014048 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 640131014049 amidase catalytic site [active] 640131014050 Zn binding residues [ion binding]; other site 640131014051 substrate binding site [chemical binding]; other site 640131014052 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 640131014053 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 640131014054 dimerization interface [polypeptide binding]; other site 640131014055 active site 640131014056 putative major pilin subunit; Provisional; Region: PRK10574 640131014057 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 640131014058 Pilin (bacterial filament); Region: Pilin; pfam00114 640131014059 hypothetical protein; Provisional; Region: PRK10436 640131014060 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 640131014061 Walker A motif; other site 640131014062 ATP binding site [chemical binding]; other site 640131014063 Walker B motif; other site 640131014064 type IV pilin biogenesis protein; Provisional; Region: PRK10573 640131014065 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 640131014066 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 640131014067 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 640131014068 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 640131014069 active site 640131014070 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 640131014071 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 640131014072 CoA-binding site [chemical binding]; other site 640131014073 ATP-binding [chemical binding]; other site 640131014074 hypothetical protein; Provisional; Region: PRK05287 640131014075 DNA gyrase inhibitor; Reviewed; Region: PRK00418 640131014076 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 640131014077 active site 640131014078 8-oxo-dGMP binding site [chemical binding]; other site 640131014079 nudix motif; other site 640131014080 metal binding site [ion binding]; metal-binding site 640131014081 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 640131014082 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 640131014083 SEC-C motif; Region: SEC-C; pfam02810 640131014084 SecA regulator SecM; Provisional; Region: PRK02943 640131014085 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 640131014086 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 640131014087 cell division protein FtsZ; Validated; Region: PRK09330 640131014088 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 640131014089 nucleotide binding site [chemical binding]; other site 640131014090 SulA interaction site; other site 640131014091 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 640131014092 Cell division protein FtsA; Region: FtsA; pfam14450 640131014093 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 640131014094 Cell division protein FtsA; Region: FtsA; pfam14450 640131014095 cell division protein FtsQ; Provisional; Region: PRK10775 640131014096 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 640131014097 Cell division protein FtsQ; Region: FtsQ; pfam03799 640131014098 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 640131014099 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 640131014100 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 640131014101 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 640131014102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 640131014103 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 640131014104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 640131014105 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 640131014106 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 640131014107 active site 640131014108 homodimer interface [polypeptide binding]; other site 640131014109 cell division protein FtsW; Provisional; Region: PRK10774 640131014110 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 640131014111 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 640131014112 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 640131014113 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 640131014114 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 640131014115 Mg++ binding site [ion binding]; other site 640131014116 putative catalytic motif [active] 640131014117 putative substrate binding site [chemical binding]; other site 640131014118 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 640131014119 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 640131014120 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 640131014121 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 640131014122 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 640131014123 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 640131014124 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 640131014125 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 640131014126 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 640131014127 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 640131014128 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 640131014129 cell division protein FtsL; Provisional; Region: PRK10772 640131014130 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 640131014131 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 640131014132 mraZ protein; Region: TIGR00242 640131014133 MraZ protein; Region: MraZ; pfam02381 640131014134 MraZ protein; Region: MraZ; pfam02381 640131014135 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 640131014136 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131014137 DNA binding site [nucleotide binding] 640131014138 domain linker motif; other site 640131014139 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 640131014140 dimerization interface [polypeptide binding]; other site 640131014141 ligand binding site [chemical binding]; other site 640131014142 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 640131014143 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 640131014144 putative valine binding site [chemical binding]; other site 640131014145 dimer interface [polypeptide binding]; other site 640131014146 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 640131014147 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 640131014148 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131014149 PYR/PP interface [polypeptide binding]; other site 640131014150 dimer interface [polypeptide binding]; other site 640131014151 TPP binding site [chemical binding]; other site 640131014152 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131014153 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 640131014154 TPP-binding site [chemical binding]; other site 640131014155 dimer interface [polypeptide binding]; other site 640131014156 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 640131014157 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014158 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 640131014159 putative substrate binding pocket [chemical binding]; other site 640131014160 putative dimerization interface [polypeptide binding]; other site 640131014161 2-isopropylmalate synthase; Validated; Region: PRK00915 640131014162 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 640131014163 active site 640131014164 catalytic residues [active] 640131014165 metal binding site [ion binding]; metal-binding site 640131014166 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 640131014167 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 640131014168 tartrate dehydrogenase; Region: TTC; TIGR02089 640131014169 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 640131014170 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 640131014171 substrate binding site [chemical binding]; other site 640131014172 ligand binding site [chemical binding]; other site 640131014173 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 640131014174 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 640131014175 substrate binding site [chemical binding]; other site 640131014176 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 640131014177 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 640131014178 active site 640131014179 FMN binding site [chemical binding]; other site 640131014180 substrate binding site [chemical binding]; other site 640131014181 putative catalytic residue [active] 640131014182 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 640131014183 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131014184 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 640131014185 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 640131014186 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 640131014187 shikimate binding site; other site 640131014188 NAD(P) binding site [chemical binding]; other site 640131014189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131014190 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 640131014191 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 640131014192 active site 640131014193 catalytic residue [active] 640131014194 dimer interface [polypeptide binding]; other site 640131014195 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131014196 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014197 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 640131014198 putative dimerization interface [polypeptide binding]; other site 640131014199 D-galactonate transporter; Region: 2A0114; TIGR00893 640131014200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014201 putative substrate translocation pore; other site 640131014202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014203 sugar efflux transporter; Region: 2A0120; TIGR00899 640131014204 putative substrate translocation pore; other site 640131014205 transcriptional regulator SgrR; Provisional; Region: PRK13626 640131014206 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 640131014207 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 640131014208 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 640131014209 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 640131014210 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 640131014211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131014212 dimer interface [polypeptide binding]; other site 640131014213 conserved gate region; other site 640131014214 putative PBP binding loops; other site 640131014215 ABC-ATPase subunit interface; other site 640131014216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131014217 dimer interface [polypeptide binding]; other site 640131014218 conserved gate region; other site 640131014219 putative PBP binding loops; other site 640131014220 ABC-ATPase subunit interface; other site 640131014221 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 640131014222 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 640131014223 Walker A/P-loop; other site 640131014224 ATP binding site [chemical binding]; other site 640131014225 Q-loop/lid; other site 640131014226 ABC transporter signature motif; other site 640131014227 Walker B; other site 640131014228 D-loop; other site 640131014229 H-loop/switch region; other site 640131014230 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 640131014231 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 640131014232 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 640131014233 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131014234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014235 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014236 ribulokinase; Provisional; Region: PRK04123 640131014237 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 640131014238 N- and C-terminal domain interface [polypeptide binding]; other site 640131014239 active site 640131014240 MgATP binding site [chemical binding]; other site 640131014241 catalytic site [active] 640131014242 metal binding site [ion binding]; metal-binding site 640131014243 carbohydrate binding site [chemical binding]; other site 640131014244 homodimer interface [polypeptide binding]; other site 640131014245 L-arabinose isomerase; Provisional; Region: PRK02929 640131014246 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 640131014247 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 640131014248 trimer interface [polypeptide binding]; other site 640131014249 putative substrate binding site [chemical binding]; other site 640131014250 putative metal binding site [ion binding]; other site 640131014251 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 640131014252 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 640131014253 intersubunit interface [polypeptide binding]; other site 640131014254 active site 640131014255 Zn2+ binding site [ion binding]; other site 640131014256 DNA polymerase II; Reviewed; Region: PRK05762 640131014257 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 640131014258 active site 640131014259 catalytic site [active] 640131014260 substrate binding site [chemical binding]; other site 640131014261 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 640131014262 active site 640131014263 metal-binding site 640131014264 ATP-dependent helicase HepA; Validated; Region: PRK04914 640131014265 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131014266 ATP binding site [chemical binding]; other site 640131014267 putative Mg++ binding site [ion binding]; other site 640131014268 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131014269 nucleotide binding region [chemical binding]; other site 640131014270 ATP-binding site [chemical binding]; other site 640131014271 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 640131014272 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 640131014273 active site 640131014274 holo-ACP synthase CitX; Region: citrate_citX; TIGR03124 640131014275 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 640131014276 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 640131014277 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 640131014278 putative active site [active] 640131014279 heme pocket [chemical binding]; other site 640131014280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131014281 ATP binding site [chemical binding]; other site 640131014282 Mg2+ binding site [ion binding]; other site 640131014283 G-X-G motif; other site 640131014284 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 640131014285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131014286 active site 640131014287 phosphorylation site [posttranslational modification] 640131014288 intermolecular recognition site; other site 640131014289 dimerization interface [polypeptide binding]; other site 640131014290 Transcriptional regulator; Region: CitT; pfam12431 640131014291 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 640131014292 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 640131014293 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 640131014294 putative metal binding site [ion binding]; other site 640131014295 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 640131014296 HSP70 interaction site [polypeptide binding]; other site 640131014297 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 640131014298 OstA-like protein; Region: OstA; pfam03968 640131014299 Organic solvent tolerance protein; Region: OstA_C; pfam04453 640131014300 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 640131014301 SurA N-terminal domain; Region: SurA_N; pfam09312 640131014302 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 640131014303 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 640131014304 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 640131014305 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 640131014306 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 640131014307 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 640131014308 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 640131014309 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 640131014310 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 640131014311 active site 640131014312 metal binding site [ion binding]; metal-binding site 640131014313 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 640131014314 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 640131014315 folate binding site [chemical binding]; other site 640131014316 NADP+ binding site [chemical binding]; other site 640131014317 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 640131014318 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 640131014319 TrkA-N domain; Region: TrkA_N; pfam02254 640131014320 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 640131014321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014322 D-galactonate transporter; Region: 2A0114; TIGR00893 640131014323 putative substrate translocation pore; other site 640131014324 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 640131014325 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 640131014326 putative ligand binding site [chemical binding]; other site 640131014327 NAD binding site [chemical binding]; other site 640131014328 catalytic site [active] 640131014329 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 640131014330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131014331 DNA binding site [nucleotide binding] 640131014332 domain linker motif; other site 640131014333 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 640131014334 putative ligand binding site [chemical binding]; other site 640131014335 putative dimerization interface [polypeptide binding]; other site 640131014336 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 640131014337 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 640131014338 NADP binding site [chemical binding]; other site 640131014339 homodimer interface [polypeptide binding]; other site 640131014340 active site 640131014341 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 640131014342 AAA domain; Region: AAA_33; pfam13671 640131014343 ATP-binding site [chemical binding]; other site 640131014344 Gluconate-6-phosphate binding site [chemical binding]; other site 640131014345 Domain of unknown function (DUF386); Region: DUF386; cl01047 640131014346 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 640131014347 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 640131014348 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 640131014349 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 640131014350 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 640131014351 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 640131014352 ATP-grasp domain; Region: ATP-grasp_4; cl17255 640131014353 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 640131014354 IMP binding site; other site 640131014355 dimer interface [polypeptide binding]; other site 640131014356 interdomain contacts; other site 640131014357 partial ornithine binding site; other site 640131014358 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 640131014359 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 640131014360 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 640131014361 catalytic site [active] 640131014362 subunit interface [polypeptide binding]; other site 640131014363 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 640131014364 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 640131014365 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 640131014366 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 640131014367 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 640131014368 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 640131014369 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 640131014370 citrate lyase subunit gamma; Provisional; Region: PRK13253 640131014371 [citrate (pro-3S)-lyase] ligase; Region: cit_ly_ligase; TIGR00124 640131014372 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 640131014373 putative active site [active] 640131014374 (T/H)XGH motif; other site 640131014375 Na+/citrate symporter [Energy production and conversion]; Region: CitS; COG3493 640131014376 oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK02919 640131014377 oxaloacetate decarboxylase; Provisional; Region: PRK14040 640131014378 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 640131014379 active site 640131014380 catalytic residues [active] 640131014381 metal binding site [ion binding]; metal-binding site 640131014382 homodimer binding site [polypeptide binding]; other site 640131014383 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 640131014384 carboxyltransferase (CT) interaction site; other site 640131014385 biotinylation site [posttranslational modification]; other site 640131014386 oxaloacetate decarboxylase subunit beta; Provisional; Region: PRK15476 640131014387 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 640131014388 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 640131014389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131014390 ATP binding site [chemical binding]; other site 640131014391 Mg2+ binding site [ion binding]; other site 640131014392 G-X-G motif; other site 640131014393 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 640131014394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131014395 active site 640131014396 phosphorylation site [posttranslational modification] 640131014397 intermolecular recognition site; other site 640131014398 dimerization interface [polypeptide binding]; other site 640131014399 Transcriptional regulator; Region: CitT; pfam12431 640131014400 alanine-tRNA ligase; Region: PLN02961 640131014401 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 640131014402 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131014403 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014404 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131014405 putative effector binding pocket; other site 640131014406 dimerization interface [polypeptide binding]; other site 640131014407 Protein of unknown function (DUF805); Region: DUF805; pfam05656 640131014408 putative hydratase; Provisional; Region: PRK11413 640131014409 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 640131014410 substrate binding site [chemical binding]; other site 640131014411 ligand binding site [chemical binding]; other site 640131014412 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 640131014413 substrate binding site [chemical binding]; other site 640131014414 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 640131014415 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 640131014416 transmembrane helices; other site 640131014417 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 640131014418 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 640131014419 transmembrane helices; other site 640131014420 PrpF protein; Region: PrpF; pfam04303 640131014421 Elongation factor 1 gamma, conserved domain; Region: EF1G; pfam00647 640131014422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131014423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014424 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 640131014425 putative dimerization interface [polypeptide binding]; other site 640131014426 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 640131014427 active site 640131014428 tetramer interface [polypeptide binding]; other site 640131014429 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 640131014430 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 640131014431 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 640131014432 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 640131014433 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 640131014434 lipoprotein signal peptidase; Provisional; Region: PRK14787 640131014435 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 640131014436 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 640131014437 active site 640131014438 HIGH motif; other site 640131014439 nucleotide binding site [chemical binding]; other site 640131014440 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 640131014441 active site 640131014442 KMSKS motif; other site 640131014443 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 640131014444 tRNA binding surface [nucleotide binding]; other site 640131014445 anticodon binding site; other site 640131014446 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 640131014447 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 640131014448 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 640131014449 active site 640131014450 Riboflavin kinase; Region: Flavokinase; smart00904 640131014451 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 640131014452 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014453 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 640131014454 putative dimerization interface [polypeptide binding]; other site 640131014455 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 640131014456 chaperone protein DnaJ; Provisional; Region: PRK10767 640131014457 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 640131014458 HSP70 interaction site [polypeptide binding]; other site 640131014459 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 640131014460 substrate binding site [polypeptide binding]; other site 640131014461 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 640131014462 Zn binding sites [ion binding]; other site 640131014463 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 640131014464 dimer interface [polypeptide binding]; other site 640131014465 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 640131014466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 640131014467 nucleotide binding site [chemical binding]; other site 640131014468 hypothetical protein; Provisional; Region: PRK10154 640131014469 hypothetical protein; Provisional; Region: PRK10236 640131014470 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 640131014471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 640131014472 hypothetical protein; Provisional; Region: PRK10659 640131014473 metabolite-proton symporter; Region: 2A0106; TIGR00883 640131014474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014475 putative substrate translocation pore; other site 640131014476 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 640131014477 MPT binding site; other site 640131014478 trimer interface [polypeptide binding]; other site 640131014479 transaldolase-like protein; Provisional; Region: PTZ00411 640131014480 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 640131014481 active site 640131014482 dimer interface [polypeptide binding]; other site 640131014483 catalytic residue [active] 640131014484 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 640131014485 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 640131014486 hypothetical protein; Validated; Region: PRK02101 640131014487 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 640131014488 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 640131014489 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 640131014490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131014491 catalytic residue [active] 640131014492 homoserine kinase; Provisional; Region: PRK01212 640131014493 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 640131014494 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 640131014495 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 640131014496 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 640131014497 putative catalytic residues [active] 640131014498 putative nucleotide binding site [chemical binding]; other site 640131014499 putative aspartate binding site [chemical binding]; other site 640131014500 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 640131014501 dimer interface [polypeptide binding]; other site 640131014502 putative threonine allosteric regulatory site; other site 640131014503 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 640131014504 putative threonine allosteric regulatory site; other site 640131014505 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 640131014506 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 640131014507 putative RNA methyltransferase; Provisional; Region: PRK10433 640131014508 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 640131014509 two-component response regulator; Provisional; Region: PRK11173 640131014510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131014511 active site 640131014512 phosphorylation site [posttranslational modification] 640131014513 intermolecular recognition site; other site 640131014514 dimerization interface [polypeptide binding]; other site 640131014515 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131014516 DNA binding site [nucleotide binding] 640131014517 Inner membrane protein CreD; Region: CreD; pfam06123 640131014518 sensory histidine kinase CreC; Provisional; Region: PRK11100 640131014519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131014520 dimer interface [polypeptide binding]; other site 640131014521 phosphorylation site [posttranslational modification] 640131014522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131014523 ATP binding site [chemical binding]; other site 640131014524 Mg2+ binding site [ion binding]; other site 640131014525 G-X-G motif; other site 640131014526 DNA-binding response regulator CreB; Provisional; Region: PRK11083 640131014527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131014528 active site 640131014529 phosphorylation site [posttranslational modification] 640131014530 intermolecular recognition site; other site 640131014531 dimerization interface [polypeptide binding]; other site 640131014532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131014533 DNA binding site [nucleotide binding] 640131014534 hypothetical protein; Provisional; Region: PRK10756 640131014535 CreA protein; Region: CreA; pfam05981 640131014536 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 640131014537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014538 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 640131014539 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 640131014540 catalytic core [active] 640131014541 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 640131014542 Trp operon repressor; Provisional; Region: PRK01381 640131014543 lytic murein transglycosylase; Provisional; Region: PRK11619 640131014544 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131014545 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131014546 catalytic residue [active] 640131014547 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 640131014548 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131014549 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131014550 ABC transporter; Region: ABC_tran_2; pfam12848 640131014551 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 640131014552 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131014553 non-specific DNA binding site [nucleotide binding]; other site 640131014554 salt bridge; other site 640131014555 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 640131014556 sequence-specific DNA binding site [nucleotide binding]; other site 640131014557 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 640131014558 active site 640131014559 (T/H)XGH motif; other site 640131014560 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 640131014561 DNA repair protein RadA; Region: sms; TIGR00416 640131014562 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 640131014563 Walker A motif/ATP binding site; other site 640131014564 ATP binding site [chemical binding]; other site 640131014565 Walker B motif; other site 640131014566 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 640131014567 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 640131014568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131014569 active site 640131014570 motif I; other site 640131014571 motif II; other site 640131014572 hypothetical protein; Provisional; Region: PRK11246 640131014573 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 640131014574 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 640131014575 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 640131014576 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 640131014577 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 640131014578 phosphopentomutase; Provisional; Region: PRK05362 640131014579 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 640131014580 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 640131014581 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 640131014582 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 640131014583 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 640131014584 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 640131014585 intersubunit interface [polypeptide binding]; other site 640131014586 active site 640131014587 catalytic residue [active] 640131014588 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 640131014589 active site 640131014590 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 640131014591 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 640131014592 active site 640131014593 nucleophile elbow; other site 640131014594 periplasmic protein; Provisional; Region: PRK10568 640131014595 BON domain; Region: BON; pfam04972 640131014596 BON domain; Region: BON; pfam04972 640131014597 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 640131014598 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 640131014599 G1 box; other site 640131014600 putative GEF interaction site [polypeptide binding]; other site 640131014601 GTP/Mg2+ binding site [chemical binding]; other site 640131014602 Switch I region; other site 640131014603 G2 box; other site 640131014604 G3 box; other site 640131014605 Switch II region; other site 640131014606 G4 box; other site 640131014607 G5 box; other site 640131014608 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 640131014609 dUMP phosphatase; Provisional; Region: PRK09449 640131014610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131014611 motif II; other site 640131014612 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 640131014613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131014614 Coenzyme A binding pocket [chemical binding]; other site 640131014615 DNA polymerase III subunit psi; Validated; Region: PRK06856 640131014616 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 640131014617 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 640131014618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131014619 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 640131014620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131014621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131014622 metal binding site [ion binding]; metal-binding site 640131014623 active site 640131014624 I-site; other site 640131014625 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 640131014626 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 640131014627 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 640131014628 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 640131014629 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 640131014630 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 640131014631 putative deacylase active site [active] 640131014632 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 640131014633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131014634 DNA binding residues [nucleotide binding] 640131014635 dimerization interface [polypeptide binding]; other site 640131014636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 640131014637 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 640131014638 DNA binding residues [nucleotide binding] 640131014639 dimerization interface [polypeptide binding]; other site 640131014640 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 640131014641 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014642 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 640131014643 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 640131014644 Uncharacterized conserved protein [Function unknown]; Region: COG2966 640131014645 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 640131014646 hypothetical protein; Provisional; Region: PRK09917 640131014647 primosomal protein DnaI; Provisional; Region: PRK02854 640131014648 DNA replication protein DnaC; Validated; Region: PRK07952 640131014649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131014650 Walker A motif; other site 640131014651 ATP binding site [chemical binding]; other site 640131014652 Walker B motif; other site 640131014653 hypothetical protein; Provisional; Region: PRK11667 640131014654 phosphoglycerol transferase I; Provisional; Region: PRK03776 640131014655 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 640131014656 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 640131014657 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 640131014658 putative active site [active] 640131014659 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 640131014660 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 640131014661 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 640131014662 dimer interface [polypeptide binding]; other site 640131014663 active site 640131014664 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 640131014665 dimer interface [polypeptide binding]; other site 640131014666 active site 640131014667 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 640131014668 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 640131014669 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 640131014670 active site 640131014671 phosphorylation site [posttranslational modification] 640131014672 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 640131014673 active pocket/dimerization site; other site 640131014674 active site 640131014675 phosphorylation site [posttranslational modification] 640131014676 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 640131014677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131014678 Walker A motif; other site 640131014679 ATP binding site [chemical binding]; other site 640131014680 Walker B motif; other site 640131014681 arginine finger; other site 640131014682 Transcriptional antiterminator [Transcription]; Region: COG3933 640131014683 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 640131014684 active pocket/dimerization site; other site 640131014685 active site 640131014686 phosphorylation site [posttranslational modification] 640131014687 PRD domain; Region: PRD; pfam00874 640131014688 altronate oxidoreductase; Provisional; Region: PRK03643 640131014689 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 640131014690 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 640131014691 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 640131014692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 640131014693 putative NAD(P) binding site [chemical binding]; other site 640131014694 catalytic Zn binding site [ion binding]; other site 640131014695 structural Zn binding site [ion binding]; other site 640131014696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131014697 DNA-binding site [nucleotide binding]; DNA binding site 640131014698 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131014699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 640131014700 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 640131014701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014702 D-galactonate transporter; Region: 2A0114; TIGR00893 640131014703 putative substrate translocation pore; other site 640131014704 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 640131014705 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131014706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131014707 Coenzyme A binding pocket [chemical binding]; other site 640131014708 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 640131014709 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 640131014710 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 640131014711 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 640131014712 dimer interface [polypeptide binding]; other site 640131014713 NADP binding site [chemical binding]; other site 640131014714 catalytic residues [active] 640131014715 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 640131014716 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 640131014717 inhibitor site; inhibition site 640131014718 active site 640131014719 dimer interface [polypeptide binding]; other site 640131014720 catalytic residue [active] 640131014721 PAS fold; Region: PAS_4; pfam08448 640131014722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131014723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014724 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 640131014725 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 640131014726 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 640131014727 hydroxyglutarate oxidase; Provisional; Region: PRK11728 640131014728 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 640131014729 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 640131014730 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 640131014731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 640131014732 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 640131014733 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 640131014734 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 640131014735 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 640131014736 NAD binding site [chemical binding]; other site 640131014737 catalytic residues [active] 640131014738 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 640131014739 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 640131014740 putative active site [active] 640131014741 putative metal binding site [ion binding]; other site 640131014742 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 640131014743 putative substrate binding pocket [chemical binding]; other site 640131014744 trimer interface [polypeptide binding]; other site 640131014745 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 640131014746 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 640131014747 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014748 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 640131014749 putative substrate translocation pore; other site 640131014750 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 640131014751 Cupin domain; Region: Cupin_2; pfam07883 640131014752 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014753 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 640131014754 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 640131014755 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 640131014756 haemagglutination activity domain; Region: Haemagg_act; pfam05860 640131014757 Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210 640131014758 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 640131014759 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 640131014760 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 640131014761 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 640131014762 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 640131014763 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 640131014764 carbon starvation protein A; Provisional; Region: PRK15015 640131014765 Carbon starvation protein CstA; Region: CstA; pfam02554 640131014766 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 640131014767 Uncharacterized small protein [Function unknown]; Region: COG2879 640131014768 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 640131014769 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 640131014770 P-loop, Walker A motif; other site 640131014771 Base recognition motif; other site 640131014772 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 640131014773 YfaZ precursor; Region: YfaZ; pfam07437 640131014774 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 640131014775 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 640131014776 NAD(P) binding site [chemical binding]; other site 640131014777 catalytic residues [active] 640131014778 putative transposase; Provisional; Region: PRK09857 640131014779 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 640131014780 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131014781 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131014782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131014783 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 640131014784 Predicted membrane protein [Function unknown]; Region: COG2733 640131014785 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 640131014786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131014787 putative substrate translocation pore; other site 640131014788 Uncharacterized conserved protein (DUF2164); Region: DUF2164; cl02278 640131014789 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 640131014790 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 640131014791 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 640131014792 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 640131014793 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 640131014794 M20 Peptidase Aminoacylase 1 amhX_like subfamily; Region: M20_Acy1_amhX_like; cd08018 640131014795 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 640131014796 metal binding site [ion binding]; metal-binding site 640131014797 putative dimer interface [polypeptide binding]; other site 640131014798 hypothetical protein; Provisional; Region: PRK10519 640131014799 Nucleoside recognition; Region: Gate; pfam07670 640131014800 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014801 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131014802 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_5; cd08426 640131014803 putative dimerization interface [polypeptide binding]; other site 640131014804 Protein of unknown function (DUF2955); Region: DUF2955; pfam11168 640131014805 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 640131014806 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131014807 transcriptional regulator SlyA; Provisional; Region: PRK03573 640131014808 MarR family; Region: MarR_2; cl17246 640131014809 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 640131014810 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 640131014811 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131014812 DNA-binding site [nucleotide binding]; DNA binding site 640131014813 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131014814 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131014815 homodimer interface [polypeptide binding]; other site 640131014816 catalytic residue [active] 640131014817 Restriction endonuclease; Region: Mrr_cat; pfam04471 640131014818 HsdM N-terminal domain; Region: HsdM_N; pfam12161 640131014819 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 640131014820 Methyltransferase domain; Region: Methyltransf_26; pfam13659 640131014821 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 640131014822 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 640131014823 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 640131014824 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 640131014825 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 640131014826 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 640131014827 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 640131014828 FosA, a Fosfomycin resistance protein, catalyzes the addition of glutathione to the antibiotic fosfomycin, making it inactive; Region: FosA; cd07244 640131014829 dimer interface [polypeptide binding]; other site 640131014830 Mn binding site [ion binding]; other site 640131014831 K binding site [ion binding]; other site 640131014832 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131014833 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131014834 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_3; cd08461 640131014835 putative substrate binding pocket [chemical binding]; other site 640131014836 putative dimerization interface [polypeptide binding]; other site 640131014837 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 640131014838 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 640131014839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 640131014840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131014841 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 640131014842 DNA binding site [nucleotide binding] 640131014843 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131014844 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 640131014845 Hexamer interface [polypeptide binding]; other site 640131014846 Hexagonal pore residue; other site 640131014847 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131014848 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 640131014849 Hexamer interface [polypeptide binding]; other site 640131014850 Hexagonal pore residue; other site 640131014851 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131014852 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 640131014853 Hexamer interface [polypeptide binding]; other site 640131014854 Hexagonal pore residue; other site 640131014855 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 640131014856 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 640131014857 putative catalytic cysteine [active] 640131014858 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 640131014859 Hexamer/Pentamer interface [polypeptide binding]; other site 640131014860 central pore; other site 640131014861 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 640131014862 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 640131014863 putative active site [active] 640131014864 metal binding site [ion binding]; metal-binding site 640131014865 Pyruvate formate lyase; Region: PFL; pfam02901 640131014866 Pyruvate formate lyase; Region: PFL; pfam02901 640131014867 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 640131014868 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 640131014869 dimer interface [polypeptide binding]; other site 640131014870 active site 640131014871 glycine loop; other site 640131014872 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 640131014873 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 640131014874 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 640131014875 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 640131014876 Hexamer interface [polypeptide binding]; other site 640131014877 Hexagonal pore residue; other site 640131014878 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 640131014879 Propanediol utilisation protein PduL; Region: PduL; pfam06130 640131014880 Propanediol utilisation protein PduL; Region: PduL; pfam06130 640131014881 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 640131014882 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 640131014883 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 640131014884 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 640131014885 active site 640131014886 HIGH motif; other site 640131014887 dimer interface [polypeptide binding]; other site 640131014888 KMSKS motif; other site 640131014889 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 640131014890 heme-binding site [chemical binding]; other site 640131014891 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131014892 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131014893 metal binding site [ion binding]; metal-binding site 640131014894 active site 640131014895 I-site; other site 640131014896 HlyD family secretion protein; Region: HlyD; pfam00529 640131014897 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131014898 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131014899 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 640131014900 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 640131014901 Walker A/P-loop; other site 640131014902 ATP binding site [chemical binding]; other site 640131014903 Q-loop/lid; other site 640131014904 ABC transporter signature motif; other site 640131014905 Walker B; other site 640131014906 D-loop; other site 640131014907 H-loop/switch region; other site 640131014908 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 640131014909 Walker A/P-loop; other site 640131014910 ATP binding site [chemical binding]; other site 640131014911 Q-loop/lid; other site 640131014912 ABC transporter signature motif; other site 640131014913 Walker B; other site 640131014914 D-loop; other site 640131014915 H-loop/switch region; other site 640131014916 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 640131014917 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 640131014918 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 640131014919 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 640131014920 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 640131014921 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 640131014922 Uncharacterized conserved protein [Function unknown]; Region: COG2850 640131014923 sensor kinase CusS; Provisional; Region: PRK09835 640131014924 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131014925 dimerization interface [polypeptide binding]; other site 640131014926 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131014927 dimer interface [polypeptide binding]; other site 640131014928 phosphorylation site [posttranslational modification] 640131014929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131014930 ATP binding site [chemical binding]; other site 640131014931 Mg2+ binding site [ion binding]; other site 640131014932 G-X-G motif; other site 640131014933 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 640131014934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131014935 active site 640131014936 phosphorylation site [posttranslational modification] 640131014937 intermolecular recognition site; other site 640131014938 dimerization interface [polypeptide binding]; other site 640131014939 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131014940 DNA binding site [nucleotide binding] 640131014941 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 640131014942 periplasmic copper-binding protein; Provisional; Region: PRK09838 640131014943 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 640131014944 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131014945 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 640131014946 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 640131014947 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 640131014948 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 640131014949 transcriptional regulator MirA; Provisional; Region: PRK15043 640131014950 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 640131014951 DNA binding residues [nucleotide binding] 640131014952 SnoaL-like domain; Region: SnoaL_2; pfam12680 640131014953 short chain dehydrogenase; Provisional; Region: PRK06101 640131014954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 640131014955 NAD(P) binding site [chemical binding]; other site 640131014956 active site 640131014957 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 640131014958 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 640131014959 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 640131014960 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 640131014961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131014962 S-adenosylmethionine binding site [chemical binding]; other site 640131014963 Protein of unknown function (DUF2878); Region: DUF2878; pfam11086 640131014964 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 640131014965 Protein of unknown function (DUF523); Region: DUF523; pfam04463 640131014966 Uncharacterized conserved protein [Function unknown]; Region: COG3272 640131014967 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 640131014968 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 640131014969 xylose isomerase; Provisional; Region: PRK05474 640131014970 xylose isomerase; Region: xylose_isom_A; TIGR02630 640131014971 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 640131014972 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 640131014973 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 640131014974 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 640131014975 inhibitor binding site; inhibition site 640131014976 active site 640131014977 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 640131014978 HNH endonuclease; Region: HNH_2; pfam13391 640131014979 Protein of unknown function (DUF796); Region: DUF796; cl01226 640131014980 Protein of unknown function (DUF2778); Region: DUF2778; pfam10908 640131014981 Transposase; Region: HTH_Tnp_1; pfam01527 640131014982 Winged helix-turn helix; Region: HTH_29; pfam13551 640131014983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131014984 S-adenosylmethionine binding site [chemical binding]; other site 640131014985 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 640131014986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 640131014987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131014988 ATP binding site [chemical binding]; other site 640131014989 Mg2+ binding site [ion binding]; other site 640131014990 G-X-G motif; other site 640131014991 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 640131014992 active site clefts [active] 640131014993 zinc binding site [ion binding]; other site 640131014994 dimer interface [polypeptide binding]; other site 640131014995 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 640131014996 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 640131014997 Sulfate transporter family; Region: Sulfate_transp; pfam00916 640131014998 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 640131014999 Sulfate transporter family; Region: Sulfate_transp; pfam00916 640131015000 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 640131015001 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 640131015002 putative NAD(P) binding site [chemical binding]; other site 640131015003 putative substrate binding site [chemical binding]; other site 640131015004 catalytic Zn binding site [ion binding]; other site 640131015005 structural Zn binding site [ion binding]; other site 640131015006 dimer interface [polypeptide binding]; other site 640131015007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131015008 dimer interface [polypeptide binding]; other site 640131015009 conserved gate region; other site 640131015010 putative PBP binding loops; other site 640131015011 ABC-ATPase subunit interface; other site 640131015012 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131015013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131015014 dimer interface [polypeptide binding]; other site 640131015015 conserved gate region; other site 640131015016 putative PBP binding loops; other site 640131015017 ABC-ATPase subunit interface; other site 640131015018 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 640131015019 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 640131015020 active site 640131015021 metal binding site [ion binding]; metal-binding site 640131015022 hexamer interface [polypeptide binding]; other site 640131015023 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 640131015024 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131015025 Walker A/P-loop; other site 640131015026 ATP binding site [chemical binding]; other site 640131015027 Q-loop/lid; other site 640131015028 ABC transporter signature motif; other site 640131015029 Walker B; other site 640131015030 D-loop; other site 640131015031 H-loop/switch region; other site 640131015032 TOBE domain; Region: TOBE_2; pfam08402 640131015033 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 640131015034 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 640131015035 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 640131015036 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 640131015037 Metal-binding active site; metal-binding site 640131015038 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 640131015039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 640131015040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 640131015041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 640131015042 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 640131015043 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131015044 PYR/PP interface [polypeptide binding]; other site 640131015045 dimer interface [polypeptide binding]; other site 640131015046 TPP binding site [chemical binding]; other site 640131015047 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131015048 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 640131015049 TPP-binding site; other site 640131015050 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131015051 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 640131015052 substrate binding site [chemical binding]; other site 640131015053 ATP binding site [chemical binding]; other site 640131015054 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 640131015055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892 640131015056 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 640131015057 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 640131015058 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 640131015059 putative active site [active] 640131015060 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 640131015061 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 640131015062 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 640131015063 tetrameric interface [polypeptide binding]; other site 640131015064 NAD binding site [chemical binding]; other site 640131015065 catalytic residues [active] 640131015066 Predicted sugar epimerase [Carbohydrate transport and metabolism]; Region: COG4130 640131015067 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 640131015068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131015069 Walker A motif; other site 640131015070 ATP binding site [chemical binding]; other site 640131015071 Walker B motif; other site 640131015072 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 640131015073 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 640131015074 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 640131015075 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 640131015076 multifunctional aminopeptidase A; Provisional; Region: PRK00913 640131015077 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 640131015078 interface (dimer of trimers) [polypeptide binding]; other site 640131015079 Substrate-binding/catalytic site; other site 640131015080 Zn-binding sites [ion binding]; other site 640131015081 DNA polymerase III subunit chi; Validated; Region: PRK05728 640131015082 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 640131015083 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 640131015084 HIGH motif; other site 640131015085 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 640131015086 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 640131015087 active site 640131015088 KMSKS motif; other site 640131015089 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 640131015090 tRNA binding surface [nucleotide binding]; other site 640131015091 anticodon binding site; other site 640131015092 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 640131015093 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 640131015094 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 640131015095 active site 640131015096 dinuclear metal binding site [ion binding]; other site 640131015097 dimerization interface [polypeptide binding]; other site 640131015098 RNase E inhibitor protein; Provisional; Region: PRK11191 640131015099 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 640131015100 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 640131015101 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 640131015102 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 640131015103 PyrBI operon leader peptide; Region: PyrBI_leader; cl11578 640131015104 Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540 640131015105 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 640131015106 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 640131015107 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 640131015108 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 640131015109 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 640131015110 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 640131015111 homotrimer interaction site [polypeptide binding]; other site 640131015112 putative active site [active] 640131015113 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 640131015114 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 640131015115 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 640131015116 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 640131015117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131015118 motif II; other site 640131015119 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 640131015120 trehalose repressor; Provisional; Region: treR; PRK09492 640131015121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131015122 DNA binding site [nucleotide binding] 640131015123 domain linker motif; other site 640131015124 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 640131015125 dimerization interface [polypeptide binding]; other site 640131015126 ligand binding site [chemical binding]; other site 640131015127 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 640131015128 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 640131015129 active site turn [active] 640131015130 phosphorylation site [posttranslational modification] 640131015131 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 640131015132 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 640131015133 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 640131015134 Ca binding site [ion binding]; other site 640131015135 active site 640131015136 catalytic site [active] 640131015137 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 640131015138 ATP cone domain; Region: ATP-cone; pfam03477 640131015139 Class III ribonucleotide reductase; Region: RNR_III; cd01675 640131015140 effector binding site; other site 640131015141 active site 640131015142 Zn binding site [ion binding]; other site 640131015143 glycine loop; other site 640131015144 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; PRK11121 640131015145 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 640131015146 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 640131015147 HTH domain; Region: HTH_11; pfam08279 640131015148 Mga helix-turn-helix domain; Region: Mga; pfam05043 640131015149 PRD domain; Region: PRD; pfam00874 640131015150 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 640131015151 active site 640131015152 P-loop; other site 640131015153 phosphorylation site [posttranslational modification] 640131015154 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131015155 active site 640131015156 phosphorylation site [posttranslational modification] 640131015157 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 640131015158 conserved hypothetical protein EF_0839/AHA_3917; Region: EF_0839; TIGR03581 640131015159 uncharacterized pyridoxal phosphate-dependent enzyme; Region: selA_rel; TIGR01437 640131015160 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 640131015161 catalytic residue [active] 640131015162 dihydroorotase; Provisional; Region: PRK09237 640131015163 Metallo-dependent hydrolases, subgroup B is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_B; cd01307 640131015164 active site 640131015165 conserved hypothetical protein EF_0833/AHA_3914; Region: EF_0833; TIGR03579 640131015166 conserved hypothetical protein EF_0832/AHA_3913; Region: EF_0832; TIGR03580 640131015167 conserved hypothetical protein EF_0831/AHA_3912; Region: EF_0831; TIGR03578 640131015168 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 640131015169 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 640131015170 Cytochrome b562; Region: Cytochrom_B562; cl01546 640131015171 peptidase PmbA; Provisional; Region: PRK11040 640131015172 hypothetical protein; Provisional; Region: PRK05255 640131015173 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 640131015174 active site 640131015175 catalytic residues [active] 640131015176 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 640131015177 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131015178 Coenzyme A binding pocket [chemical binding]; other site 640131015179 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 640131015180 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 640131015181 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 640131015182 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 640131015183 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 640131015184 AMP binding site [chemical binding]; other site 640131015185 metal binding site [ion binding]; metal-binding site 640131015186 active site 640131015187 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131015188 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131015189 TM-ABC transporter signature motif; other site 640131015190 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131015191 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131015192 TM-ABC transporter signature motif; other site 640131015193 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131015194 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131015195 Walker A/P-loop; other site 640131015196 ATP binding site [chemical binding]; other site 640131015197 Q-loop/lid; other site 640131015198 ABC transporter signature motif; other site 640131015199 Walker B; other site 640131015200 D-loop; other site 640131015201 H-loop/switch region; other site 640131015202 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131015203 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 640131015204 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 640131015205 putative ligand binding site [chemical binding]; other site 640131015206 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 640131015207 dimer interface [polypeptide binding]; other site 640131015208 substrate binding site [chemical binding]; other site 640131015209 metal binding sites [ion binding]; metal-binding site 640131015210 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 640131015211 putative active site pocket [active] 640131015212 dimerization interface [polypeptide binding]; other site 640131015213 putative catalytic residue [active] 640131015214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 640131015215 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 640131015216 Family of unknown function (DUF490); Region: DUF490; pfam04357 640131015217 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 640131015218 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131015219 Surface antigen; Region: Bac_surface_Ag; pfam01103 640131015220 methionine sulfoxide reductase A; Provisional; Region: PRK00058 640131015221 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 640131015222 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 640131015223 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 640131015224 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 640131015225 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 640131015226 inhibitor site; inhibition site 640131015227 active site 640131015228 dimer interface [polypeptide binding]; other site 640131015229 catalytic residue [active] 640131015230 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131015231 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131015232 DNA binding site [nucleotide binding] 640131015233 domain linker motif; other site 640131015234 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_7; cd06285 640131015235 putative dimerization interface [polypeptide binding]; other site 640131015236 putative ligand binding site [chemical binding]; other site 640131015237 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 640131015238 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 640131015239 Domain of unknown function DUF21; Region: DUF21; pfam01595 640131015240 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 640131015241 Transporter associated domain; Region: CorC_HlyC; smart01091 640131015242 galactoside permease; Reviewed; Region: lacY; PRK09528 640131015243 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 640131015244 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 640131015245 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 640131015246 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 640131015247 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131015248 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015250 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 640131015251 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 640131015252 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 640131015253 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 640131015254 active site 640131015255 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 640131015256 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 640131015257 active site 640131015258 metal binding site [ion binding]; metal-binding site 640131015259 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 640131015260 Predicted transcriptional regulators [Transcription]; Region: COG1733 640131015261 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 640131015262 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 640131015263 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 640131015264 NADP binding site [chemical binding]; other site 640131015265 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131015266 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 640131015267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015268 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015269 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 640131015270 EamA-like transporter family; Region: EamA; pfam00892 640131015271 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 640131015272 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 640131015273 Hemerythrin-like domain; Region: Hr-like; cd12108 640131015274 Fe binding site [ion binding]; other site 640131015275 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 640131015276 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 640131015277 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 640131015278 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 640131015279 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 640131015280 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 640131015281 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 640131015282 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 640131015283 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 640131015284 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 640131015285 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 640131015286 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 640131015287 dimer interface [polypeptide binding]; other site 640131015288 ssDNA binding site [nucleotide binding]; other site 640131015289 tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131015290 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 640131015291 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131015292 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131015293 Major Facilitator Superfamily; Region: MFS_1; pfam07690 640131015294 putative substrate translocation pore; other site 640131015295 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 640131015296 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 640131015297 intersubunit interface [polypeptide binding]; other site 640131015298 active site 640131015299 Zn2+ binding site [ion binding]; other site 640131015300 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 640131015301 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 640131015302 AP (apurinic/apyrimidinic) site pocket; other site 640131015303 DNA interaction; other site 640131015304 Metal-binding active site; metal-binding site 640131015305 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 640131015306 active site 640131015307 dimer interface [polypeptide binding]; other site 640131015308 magnesium binding site [ion binding]; other site 640131015309 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131015310 active site 640131015311 phosphorylation site [posttranslational modification] 640131015312 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 640131015313 active site 640131015314 P-loop; other site 640131015315 phosphorylation site [posttranslational modification] 640131015316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 640131015317 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 640131015318 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 640131015319 transcriptional repressor UlaR; Provisional; Region: PRK13509 640131015320 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 640131015321 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 640131015322 esterase; Provisional; Region: PRK10566 640131015323 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 640131015324 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 640131015325 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 640131015326 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 640131015327 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 640131015328 active site 640131015329 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 640131015330 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 640131015331 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 640131015332 exoribonuclease R; Provisional; Region: PRK11642 640131015333 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 640131015334 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 640131015335 RNB domain; Region: RNB; pfam00773 640131015336 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 640131015337 RNA binding site [nucleotide binding]; other site 640131015338 Predicted transcriptional regulator [Transcription]; Region: COG1959 640131015339 transcriptional repressor NsrR; Provisional; Region: PRK11014 640131015340 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 640131015341 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 640131015342 GDP-binding site [chemical binding]; other site 640131015343 ACT binding site; other site 640131015344 IMP binding site; other site 640131015345 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 640131015346 FtsH protease regulator HflC; Provisional; Region: PRK11029 640131015347 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 640131015348 FtsH protease regulator HflK; Provisional; Region: PRK10930 640131015349 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 640131015350 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 640131015351 GTPase HflX; Provisional; Region: PRK11058 640131015352 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 640131015353 HflX GTPase family; Region: HflX; cd01878 640131015354 G1 box; other site 640131015355 GTP/Mg2+ binding site [chemical binding]; other site 640131015356 Switch I region; other site 640131015357 G2 box; other site 640131015358 G3 box; other site 640131015359 Switch II region; other site 640131015360 G4 box; other site 640131015361 G5 box; other site 640131015362 bacterial Hfq-like; Region: Hfq; cd01716 640131015363 hexamer interface [polypeptide binding]; other site 640131015364 Sm1 motif; other site 640131015365 RNA binding site [nucleotide binding]; other site 640131015366 Sm2 motif; other site 640131015367 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 640131015368 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 640131015369 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 640131015370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131015371 ATP binding site [chemical binding]; other site 640131015372 Mg2+ binding site [ion binding]; other site 640131015373 G-X-G motif; other site 640131015374 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 640131015375 ATP binding site [chemical binding]; other site 640131015376 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 640131015377 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 640131015378 AMIN domain; Region: AMIN; pfam11741 640131015379 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 640131015380 active site 640131015381 metal binding site [ion binding]; metal-binding site 640131015382 ADP-binding protein; Provisional; Region: PRK10646 640131015383 putative carbohydrate kinase; Provisional; Region: PRK10565 640131015384 Uncharacterized conserved protein [Function unknown]; Region: COG0062 640131015385 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 640131015386 putative substrate binding site [chemical binding]; other site 640131015387 putative ATP binding site [chemical binding]; other site 640131015388 epoxyqueuosine reductase; Region: TIGR00276 640131015389 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 640131015390 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 640131015391 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131015392 substrate binding pocket [chemical binding]; other site 640131015393 membrane-bound complex binding site; other site 640131015394 hinge residues; other site 640131015395 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 640131015396 catalytic site [active] 640131015397 putative active site [active] 640131015398 putative substrate binding site [chemical binding]; other site 640131015399 dimer interface [polypeptide binding]; other site 640131015400 GTPase RsgA; Reviewed; Region: PRK12288 640131015401 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 640131015402 RNA binding site [nucleotide binding]; other site 640131015403 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 640131015404 GTPase/Zn-binding domain interface [polypeptide binding]; other site 640131015405 GTP/Mg2+ binding site [chemical binding]; other site 640131015406 G4 box; other site 640131015407 G5 box; other site 640131015408 G1 box; other site 640131015409 Switch I region; other site 640131015410 G2 box; other site 640131015411 G3 box; other site 640131015412 Switch II region; other site 640131015413 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 640131015414 putative mechanosensitive channel protein; Provisional; Region: PRK10929 640131015415 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 640131015416 putative YPXnL-motif binding site; other site 640131015417 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 640131015418 Mechanosensitive ion channel; Region: MS_channel; pfam00924 640131015419 inner membrane transporter YjeM; Provisional; Region: PRK15238 640131015420 poxB regulator PoxA; Provisional; Region: PRK09350 640131015421 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 640131015422 motif 1; other site 640131015423 dimer interface [polypeptide binding]; other site 640131015424 active site 640131015425 motif 2; other site 640131015426 motif 3; other site 640131015427 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 640131015428 L-aspartate oxidase; Provisional; Region: PRK06175 640131015429 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 640131015430 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 640131015431 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 640131015432 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 640131015433 D-subunit interface [polypeptide binding]; other site 640131015434 Iron-sulfur protein interface; other site 640131015435 proximal quinone binding site [chemical binding]; other site 640131015436 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 640131015437 Iron-sulfur protein interface; other site 640131015438 proximal quinone binding site [chemical binding]; other site 640131015439 C-subunit interface; other site 640131015440 distal quinone binding site; other site 640131015441 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 640131015442 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 640131015443 multidrug efflux system protein; Provisional; Region: PRK11431 640131015444 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 640131015445 Predicted small secreted protein [Function unknown]; Region: COG5510 640131015446 elongation factor P; Validated; Region: PRK00529 640131015447 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 640131015448 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 640131015449 RNA binding site [nucleotide binding]; other site 640131015450 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 640131015451 RNA binding site [nucleotide binding]; other site 640131015452 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 640131015453 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131015454 FeS/SAM binding site; other site 640131015455 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 640131015456 DNA binding site [nucleotide binding] 640131015457 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 640131015458 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 640131015459 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131015460 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131015461 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131015462 PapC N-terminal domain; Region: PapC_N; pfam13954 640131015463 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131015464 PapC C-terminal domain; Region: PapC_C; pfam13953 640131015465 Fimbrial protein; Region: Fimbrial; pfam00419 640131015466 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 640131015467 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 640131015468 HlyD family secretion protein; Region: HlyD_3; pfam13437 640131015469 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 640131015470 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 640131015471 putative active site [active] 640131015472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 640131015473 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 640131015474 Walker A/P-loop; other site 640131015475 ATP binding site [chemical binding]; other site 640131015476 Q-loop/lid; other site 640131015477 ABC transporter signature motif; other site 640131015478 Walker B; other site 640131015479 D-loop; other site 640131015480 H-loop/switch region; other site 640131015481 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 640131015482 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 640131015483 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 640131015484 ring oligomerisation interface [polypeptide binding]; other site 640131015485 ATP/Mg binding site [chemical binding]; other site 640131015486 stacking interactions; other site 640131015487 hinge regions; other site 640131015488 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 640131015489 oligomerisation interface [polypeptide binding]; other site 640131015490 mobile loop; other site 640131015491 roof hairpin; other site 640131015492 putative transporter; Provisional; Region: PRK11021 640131015493 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 640131015494 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 640131015495 Aspartase; Region: Aspartase; cd01357 640131015496 active sites [active] 640131015497 tetramer interface [polypeptide binding]; other site 640131015498 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 640131015499 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 640131015500 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 640131015501 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 640131015502 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 640131015503 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 640131015504 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 640131015505 DsbD alpha interface [polypeptide binding]; other site 640131015506 catalytic residues [active] 640131015507 putative transcriptional regulator; Provisional; Region: PRK11640 640131015508 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 640131015509 PerC transcriptional activator; Region: PerC; pfam06069 640131015510 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 640131015511 dimerization interface [polypeptide binding]; other site 640131015512 DNA binding residues [nucleotide binding] 640131015513 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 640131015514 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 640131015515 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 640131015516 putative active site [active] 640131015517 putative metal binding site [ion binding]; other site 640131015518 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 640131015519 N-glycosyltransferase; Provisional; Region: PRK11204 640131015520 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 640131015521 DXD motif; other site 640131015522 hemin storage system protein; Provisional; Region: hmsS; PRK14584 640131015523 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 640131015524 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 640131015525 catalytic residues [active] 640131015526 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 640131015527 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 640131015528 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 640131015529 HSP70 interaction site [polypeptide binding]; other site 640131015530 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 640131015531 substrate binding site [polypeptide binding]; other site 640131015532 dimer interface [polypeptide binding]; other site 640131015533 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 640131015534 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 640131015535 Plasmid stability protein; Region: Plasmid_stab_B; pfam10784 640131015536 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 640131015537 PRTRC system protein D; Region: PRTRC_D; TIGR03739 640131015538 Mg binding site [ion binding]; other site 640131015539 nucleotide binding site [chemical binding]; other site 640131015540 putative protofilament interface [polypeptide binding]; other site 640131015541 melibiose:sodium symporter; Provisional; Region: PRK10429 640131015542 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 640131015543 alpha-galactosidase; Provisional; Region: PRK15076 640131015544 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 640131015545 NAD binding site [chemical binding]; other site 640131015546 sugar binding site [chemical binding]; other site 640131015547 divalent metal binding site [ion binding]; other site 640131015548 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131015549 dimer interface [polypeptide binding]; other site 640131015550 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 640131015551 Cupin domain; Region: Cupin_2; cl17218 640131015552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015553 proline/glycine betaine transporter; Provisional; Region: PRK10642 640131015554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131015555 putative substrate translocation pore; other site 640131015556 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 640131015557 hypothetical protein; Provisional; Region: PRK10220 640131015558 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 640131015559 PhnA protein; Region: PhnA; pfam03831 640131015560 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 640131015561 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 640131015562 dimer interface [polypeptide binding]; other site 640131015563 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 640131015564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131015565 DNA-binding site [nucleotide binding]; DNA binding site 640131015566 UTRA domain; Region: UTRA; pfam07702 640131015567 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 640131015568 carbon-phosphorus lyase complex subunit; Validated; Region: phnH; PRK10147 640131015569 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 640131015570 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 640131015571 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 640131015572 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 640131015573 Walker A/P-loop; other site 640131015574 ATP binding site [chemical binding]; other site 640131015575 Q-loop/lid; other site 640131015576 ABC transporter signature motif; other site 640131015577 Walker B; other site 640131015578 D-loop; other site 640131015579 H-loop/switch region; other site 640131015580 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 640131015581 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 640131015582 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 640131015583 Walker A/P-loop; other site 640131015584 ATP binding site [chemical binding]; other site 640131015585 Q-loop/lid; other site 640131015586 ABC transporter signature motif; other site 640131015587 Walker B; other site 640131015588 D-loop; other site 640131015589 H-loop/switch region; other site 640131015590 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 640131015591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 640131015592 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 640131015593 active site 640131015594 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 640131015595 active site 640131015596 putative hydrolase; Provisional; Region: PRK02113 640131015597 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 640131015598 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131015599 dimerization interface [polypeptide binding]; other site 640131015600 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131015601 dimer interface [polypeptide binding]; other site 640131015602 phosphorylation site [posttranslational modification] 640131015603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131015604 ATP binding site [chemical binding]; other site 640131015605 Mg2+ binding site [ion binding]; other site 640131015606 G-X-G motif; other site 640131015607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131015608 active site 640131015609 phosphorylation site [posttranslational modification] 640131015610 intermolecular recognition site; other site 640131015611 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131015612 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131015613 Walker A/P-loop; other site 640131015614 ATP binding site [chemical binding]; other site 640131015615 Q-loop/lid; other site 640131015616 ABC transporter signature motif; other site 640131015617 Walker B; other site 640131015618 D-loop; other site 640131015619 H-loop/switch region; other site 640131015620 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131015621 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131015622 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131015623 TM-ABC transporter signature motif; other site 640131015624 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 640131015625 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 640131015626 putative ligand binding site [chemical binding]; other site 640131015627 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 640131015628 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131015629 substrate binding site [chemical binding]; other site 640131015630 ATP binding site [chemical binding]; other site 640131015631 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 640131015632 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 640131015633 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 640131015634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131015635 active site 640131015636 phosphorylation site [posttranslational modification] 640131015637 intermolecular recognition site; other site 640131015638 dimerization interface [polypeptide binding]; other site 640131015639 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131015640 DNA binding site [nucleotide binding] 640131015641 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 640131015642 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 640131015643 [4Fe-4S] binding site [ion binding]; other site 640131015644 molybdopterin cofactor binding site; other site 640131015645 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 640131015646 molybdopterin cofactor binding site; other site 640131015647 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 640131015648 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 640131015649 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 640131015650 acetyl-CoA synthetase; Provisional; Region: PRK00174 640131015651 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 640131015652 active site 640131015653 CoA binding site [chemical binding]; other site 640131015654 acyl-activating enzyme (AAE) consensus motif; other site 640131015655 AMP binding site [chemical binding]; other site 640131015656 acetate binding site [chemical binding]; other site 640131015657 Predicted membrane protein [Function unknown]; Region: COG3162 640131015658 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 640131015659 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 640131015660 Na binding site [ion binding]; other site 640131015661 putative major fimbrial protein SthE; Provisional; Region: PRK15292 640131015662 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131015663 Fimbrial protein; Region: Fimbrial; cl01416 640131015664 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 640131015665 PapC N-terminal domain; Region: PapC_N; pfam13954 640131015666 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 640131015667 PapC C-terminal domain; Region: PapC_C; pfam13953 640131015668 fimbrial assembly chaperone SthB; Provisional; Region: PRK15295 640131015669 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 640131015670 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 640131015671 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 640131015672 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 640131015673 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 640131015674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131015675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131015676 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 640131015677 putative dimerization interface [polypeptide binding]; other site 640131015678 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 640131015679 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 640131015680 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 640131015681 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 640131015682 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 640131015683 putative C-terminal domain interface [polypeptide binding]; other site 640131015684 putative GSH binding site (G-site) [chemical binding]; other site 640131015685 putative dimer interface [polypeptide binding]; other site 640131015686 C-terminal, alpha helical domain of GTT1-like Glutathione S-transferases; Region: GST_C_GTT1_like; cd03189 640131015687 putative N-terminal domain interface [polypeptide binding]; other site 640131015688 putative dimer interface [polypeptide binding]; other site 640131015689 putative substrate binding pocket (H-site) [chemical binding]; other site 640131015690 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 640131015691 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 640131015692 DNA binding residues [nucleotide binding] 640131015693 dimer interface [polypeptide binding]; other site 640131015694 [2Fe-2S] cluster binding site [ion binding]; other site 640131015695 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 640131015696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015697 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 640131015698 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 640131015699 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 640131015700 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 640131015701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131015702 dimer interface [polypeptide binding]; other site 640131015703 conserved gate region; other site 640131015704 putative PBP binding loops; other site 640131015705 ABC-ATPase subunit interface; other site 640131015706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131015707 dimer interface [polypeptide binding]; other site 640131015708 conserved gate region; other site 640131015709 putative PBP binding loops; other site 640131015710 ABC-ATPase subunit interface; other site 640131015711 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 640131015712 hypothetical protein; Provisional; Region: PRK11622 640131015713 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 640131015714 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 640131015715 Walker A/P-loop; other site 640131015716 ATP binding site [chemical binding]; other site 640131015717 Q-loop/lid; other site 640131015718 ABC transporter signature motif; other site 640131015719 Walker B; other site 640131015720 D-loop; other site 640131015721 H-loop/switch region; other site 640131015722 TOBE domain; Region: TOBE_2; pfam08402 640131015723 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 640131015724 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131015725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 640131015726 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 640131015727 putative dimerization interface [polypeptide binding]; other site 640131015728 putative ligand binding site [chemical binding]; other site 640131015729 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 640131015730 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 640131015731 active site 640131015732 anti-adapter protein IraM; Provisional; Region: PRK09919 640131015733 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131015734 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131015735 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 640131015736 putative effector binding pocket; other site 640131015737 dimerization interface [polypeptide binding]; other site 640131015738 Major royal jelly protein; Region: MRJP; pfam03022 640131015739 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 640131015740 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131015741 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131015742 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131015743 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131015744 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 640131015745 Surface antigen; Region: Bac_surface_Ag; pfam01103 640131015746 Tannase and feruloyl esterase; Region: Tannase; pfam07519 640131015747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131015748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131015749 outer membrane receptor FepA; Provisional; Region: PRK13524 640131015750 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131015751 N-terminal plug; other site 640131015752 ligand-binding site [chemical binding]; other site 640131015753 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 640131015754 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131015755 substrate binding pocket [chemical binding]; other site 640131015756 membrane-bound complex binding site; other site 640131015757 hinge residues; other site 640131015758 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 640131015759 N-acetyl-D-glucosamine binding site [chemical binding]; other site 640131015760 catalytic residue [active] 640131015761 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 640131015762 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 640131015763 dimer interface [polypeptide binding]; other site 640131015764 ssDNA binding site [nucleotide binding]; other site 640131015765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 640131015766 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 640131015767 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 640131015768 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 640131015769 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 640131015770 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 640131015771 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 640131015772 Uncharacterized conserved protein [Function unknown]; Region: COG0432 640131015773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131015774 active site 640131015775 motif I; other site 640131015776 motif II; other site 640131015777 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 640131015778 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 640131015779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131015780 homodimer interface [polypeptide binding]; other site 640131015781 catalytic residue [active] 640131015782 alanine racemase; Reviewed; Region: alr; PRK00053 640131015783 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 640131015784 active site 640131015785 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 640131015786 substrate binding site [chemical binding]; other site 640131015787 catalytic residues [active] 640131015788 dimer interface [polypeptide binding]; other site 640131015789 replicative DNA helicase; Provisional; Region: PRK08006 640131015790 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 640131015791 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 640131015792 Walker A motif; other site 640131015793 ATP binding site [chemical binding]; other site 640131015794 Walker B motif; other site 640131015795 DNA binding loops [nucleotide binding] 640131015796 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 640131015797 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 640131015798 NADP binding site [chemical binding]; other site 640131015799 dimer interface [polypeptide binding]; other site 640131015800 phage shock protein G; Reviewed; Region: pspG; PRK09459 640131015801 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 640131015802 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 640131015803 FMN binding site [chemical binding]; other site 640131015804 active site 640131015805 catalytic residues [active] 640131015806 substrate binding site [chemical binding]; other site 640131015807 Cupin domain; Region: Cupin_2; cl17218 640131015808 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 640131015809 metal binding site 2 [ion binding]; metal-binding site 640131015810 putative DNA binding helix; other site 640131015811 metal binding site 1 [ion binding]; metal-binding site 640131015812 dimer interface [polypeptide binding]; other site 640131015813 structural Zn2+ binding site [ion binding]; other site 640131015814 hypothetical protein; Provisional; Region: PRK10428 640131015815 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 640131015816 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 640131015817 LexA repressor; Validated; Region: PRK00215 640131015818 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 640131015819 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 640131015820 Catalytic site [active] 640131015821 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 640131015822 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 640131015823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 640131015824 putative acyl-acceptor binding pocket; other site 640131015825 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 640131015826 UbiA prenyltransferase family; Region: UbiA; pfam01040 640131015827 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 640131015828 maltose regulon periplasmic protein; Provisional; Region: PRK10564 640131015829 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131015830 trimer interface; other site 640131015831 sugar binding site [chemical binding]; other site 640131015832 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 640131015833 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 640131015834 Walker A/P-loop; other site 640131015835 ATP binding site [chemical binding]; other site 640131015836 Q-loop/lid; other site 640131015837 ABC transporter signature motif; other site 640131015838 Walker B; other site 640131015839 D-loop; other site 640131015840 H-loop/switch region; other site 640131015841 TOBE domain; Region: TOBE_2; pfam08402 640131015842 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 640131015843 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 640131015844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131015845 dimer interface [polypeptide binding]; other site 640131015846 conserved gate region; other site 640131015847 putative PBP binding loops; other site 640131015848 ABC-ATPase subunit interface; other site 640131015849 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 640131015850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131015851 dimer interface [polypeptide binding]; other site 640131015852 conserved gate region; other site 640131015853 putative PBP binding loops; other site 640131015854 ABC-ATPase subunit interface; other site 640131015855 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 640131015856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 640131015857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131015858 Coenzyme A binding pocket [chemical binding]; other site 640131015859 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 640131015860 putative trimer interface [polypeptide binding]; other site 640131015861 putative active site [active] 640131015862 putative substrate binding site [chemical binding]; other site 640131015863 putative CoA binding site [chemical binding]; other site 640131015864 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 640131015865 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 640131015866 active site 640131015867 dimer interface [polypeptide binding]; other site 640131015868 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 640131015869 dimer interface [polypeptide binding]; other site 640131015870 active site 640131015871 aspartate kinase III; Validated; Region: PRK09084 640131015872 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 640131015873 nucleotide binding site [chemical binding]; other site 640131015874 substrate binding site [chemical binding]; other site 640131015875 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 640131015876 lysine allosteric regulatory site; other site 640131015877 dimer interface [polypeptide binding]; other site 640131015878 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 640131015879 dimer interface [polypeptide binding]; other site 640131015880 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 640131015881 Sodium Bile acid symporter family; Region: SBF; pfam01758 640131015882 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 640131015883 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 640131015884 hypothetical protein; Provisional; Region: PRK10515 640131015885 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 640131015886 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 640131015887 RNA binding surface [nucleotide binding]; other site 640131015888 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 640131015889 probable active site [active] 640131015890 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 640131015891 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131015892 putative DNA binding site [nucleotide binding]; other site 640131015893 putative Zn2+ binding site [ion binding]; other site 640131015894 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 640131015895 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 640131015896 classical (c) SDRs; Region: SDR_c; cd05233 640131015897 NAD(P) binding site [chemical binding]; other site 640131015898 active site 640131015899 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 640131015900 active pocket/dimerization site; other site 640131015901 active site 640131015902 phosphorylation site [posttranslational modification] 640131015903 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 640131015904 active site 640131015905 phosphorylation site [posttranslational modification] 640131015906 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 640131015907 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 640131015908 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 640131015909 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 640131015910 putative NAD(P) binding site [chemical binding]; other site 640131015911 catalytic Zn binding site [ion binding]; other site 640131015912 shikimate 5-dehydrogenase; Reviewed; Region: PRK12550 640131015913 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 640131015914 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 640131015915 shikimate binding site; other site 640131015916 NAD(P) binding site [chemical binding]; other site 640131015917 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 640131015918 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 640131015919 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 640131015920 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 640131015921 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 640131015922 substrate binding pocket [chemical binding]; other site 640131015923 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 640131015924 B12 binding site [chemical binding]; other site 640131015925 cobalt ligand [ion binding]; other site 640131015926 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 640131015927 transcriptional repressor IclR; Provisional; Region: PRK11569 640131015928 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 640131015929 Bacterial transcriptional regulator; Region: IclR; pfam01614 640131015930 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 640131015931 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 640131015932 isocitrate lyase; Provisional; Region: PRK15063 640131015933 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 640131015934 tetramer interface [polypeptide binding]; other site 640131015935 active site 640131015936 Mg2+/Mn2+ binding site [ion binding]; other site 640131015937 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 640131015938 malate synthase A; Region: malate_syn_A; TIGR01344 640131015939 active site 640131015940 homoserine O-succinyltransferase; Provisional; Region: PRK05368 640131015941 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 640131015942 proposed active site lysine [active] 640131015943 conserved cys residue [active] 640131015944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 640131015945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131015946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 640131015947 Coenzyme A binding pocket [chemical binding]; other site 640131015948 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 640131015949 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 640131015950 purine monophosphate binding site [chemical binding]; other site 640131015951 dimer interface [polypeptide binding]; other site 640131015952 putative catalytic residues [active] 640131015953 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 640131015954 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 640131015955 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 640131015956 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 640131015957 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 640131015958 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 640131015959 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 640131015960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131015961 active site 640131015962 phosphorylation site [posttranslational modification] 640131015963 intermolecular recognition site; other site 640131015964 dimerization interface [polypeptide binding]; other site 640131015965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131015966 Walker A motif; other site 640131015967 ATP binding site [chemical binding]; other site 640131015968 Walker B motif; other site 640131015969 arginine finger; other site 640131015970 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131015971 sensor protein ZraS; Provisional; Region: PRK10364 640131015972 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131015973 dimer interface [polypeptide binding]; other site 640131015974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131015975 ATP binding site [chemical binding]; other site 640131015976 Mg2+ binding site [ion binding]; other site 640131015977 G-X-G motif; other site 640131015978 zinc resistance protein; Provisional; Region: zraP; PRK11546 640131015979 dimer interface [polypeptide binding]; other site 640131015980 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 640131015981 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 640131015982 IHF dimer interface [polypeptide binding]; other site 640131015983 IHF - DNA interface [nucleotide binding]; other site 640131015984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 640131015985 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 640131015986 Active_site [active] 640131015987 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 640131015988 substrate binding site [chemical binding]; other site 640131015989 active site 640131015990 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 640131015991 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 640131015992 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 640131015993 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 640131015994 putative NADH binding site [chemical binding]; other site 640131015995 putative active site [active] 640131015996 nudix motif; other site 640131015997 putative metal binding site [ion binding]; other site 640131015998 anti-RNA polymerase sigma 70 factor; Provisional; Region: PRK11718 640131015999 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 640131016000 ThiC-associated domain; Region: ThiC-associated; pfam13667 640131016001 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 640131016002 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 640131016003 thiamine phosphate binding site [chemical binding]; other site 640131016004 active site 640131016005 pyrophosphate binding site [ion binding]; other site 640131016006 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 640131016007 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 640131016008 ATP binding site [chemical binding]; other site 640131016009 substrate interface [chemical binding]; other site 640131016010 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 640131016011 thiS-thiF/thiG interaction site; other site 640131016012 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 640131016013 ThiS interaction site; other site 640131016014 putative active site [active] 640131016015 tetramer interface [polypeptide binding]; other site 640131016016 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 640131016017 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131016018 FeS/SAM binding site; other site 640131016019 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 640131016020 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 640131016021 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 640131016022 metal binding site [ion binding]; metal-binding site 640131016023 active site 640131016024 I-site; other site 640131016025 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 640131016026 active site 640131016027 P-loop; other site 640131016028 phosphorylation site [posttranslational modification] 640131016029 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 640131016030 methionine cluster; other site 640131016031 active site 640131016032 phosphorylation site [posttranslational modification] 640131016033 metal binding site [ion binding]; metal-binding site 640131016034 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 640131016035 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 640131016036 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 640131016037 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 640131016038 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 640131016039 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 640131016040 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 640131016041 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 640131016042 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 640131016043 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 640131016044 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 640131016045 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 640131016046 DNA binding site [nucleotide binding] 640131016047 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 640131016048 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 640131016049 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 640131016050 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 640131016051 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 640131016052 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 640131016053 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 640131016054 RPB3 interaction site [polypeptide binding]; other site 640131016055 RPB1 interaction site [polypeptide binding]; other site 640131016056 RPB11 interaction site [polypeptide binding]; other site 640131016057 RPB10 interaction site [polypeptide binding]; other site 640131016058 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 640131016059 core dimer interface [polypeptide binding]; other site 640131016060 peripheral dimer interface [polypeptide binding]; other site 640131016061 L10 interface [polypeptide binding]; other site 640131016062 L11 interface [polypeptide binding]; other site 640131016063 putative EF-Tu interaction site [polypeptide binding]; other site 640131016064 putative EF-G interaction site [polypeptide binding]; other site 640131016065 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 640131016066 23S rRNA interface [nucleotide binding]; other site 640131016067 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 640131016068 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 640131016069 mRNA/rRNA interface [nucleotide binding]; other site 640131016070 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 640131016071 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 640131016072 23S rRNA interface [nucleotide binding]; other site 640131016073 L7/L12 interface [polypeptide binding]; other site 640131016074 putative thiostrepton binding site; other site 640131016075 L25 interface [polypeptide binding]; other site 640131016076 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 640131016077 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 640131016078 putative homodimer interface [polypeptide binding]; other site 640131016079 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 640131016080 heterodimer interface [polypeptide binding]; other site 640131016081 homodimer interface [polypeptide binding]; other site 640131016082 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 640131016083 elongation factor Tu; Reviewed; Region: PRK00049 640131016084 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 640131016085 G1 box; other site 640131016086 GEF interaction site [polypeptide binding]; other site 640131016087 GTP/Mg2+ binding site [chemical binding]; other site 640131016088 Switch I region; other site 640131016089 G2 box; other site 640131016090 G3 box; other site 640131016091 Switch II region; other site 640131016092 G4 box; other site 640131016093 G5 box; other site 640131016094 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 640131016095 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 640131016096 Antibiotic Binding Site [chemical binding]; other site 640131016097 pantothenate kinase; Provisional; Region: PRK05439 640131016098 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 640131016099 ATP-binding site [chemical binding]; other site 640131016100 CoA-binding site [chemical binding]; other site 640131016101 Mg2+-binding site [ion binding]; other site 640131016102 Biotin operon repressor [Transcription]; Region: BirA; COG1654 640131016103 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 640131016104 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 640131016105 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 640131016106 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 640131016107 FAD binding domain; Region: FAD_binding_4; pfam01565 640131016108 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 640131016109 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 640131016110 potassium transporter; Provisional; Region: PRK10750 640131016111 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 640131016112 hypothetical protein; Provisional; Region: PRK11568 640131016113 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 640131016114 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 640131016115 proline dipeptidase; Provisional; Region: PRK13607 640131016116 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 640131016117 active site 640131016118 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 640131016119 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 640131016120 substrate binding site [chemical binding]; other site 640131016121 oxyanion hole (OAH) forming residues; other site 640131016122 trimer interface [polypeptide binding]; other site 640131016123 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 640131016124 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131016125 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 640131016126 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 640131016127 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 640131016128 dimer interface [polypeptide binding]; other site 640131016129 active site 640131016130 FMN reductase; Validated; Region: fre; PRK08051 640131016131 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 640131016132 FAD binding pocket [chemical binding]; other site 640131016133 FAD binding motif [chemical binding]; other site 640131016134 phosphate binding motif [ion binding]; other site 640131016135 beta-alpha-beta structure motif; other site 640131016136 NAD binding pocket [chemical binding]; other site 640131016137 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 640131016138 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 640131016139 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 640131016140 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 640131016141 active site 640131016142 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 640131016143 sec-independent translocase; Provisional; Region: PRK01770 640131016144 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 640131016145 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 640131016146 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 640131016147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 640131016148 SCP-2 sterol transfer family; Region: SCP2; pfam02036 640131016149 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 640131016150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131016151 S-adenosylmethionine binding site [chemical binding]; other site 640131016152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 640131016153 DNA recombination protein RmuC; Provisional; Region: PRK10361 640131016154 RmuC family; Region: RmuC; pfam02646 640131016155 uridine phosphorylase; Provisional; Region: PRK11178 640131016156 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 640131016157 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 640131016158 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 640131016159 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 640131016160 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 640131016161 THF binding site; other site 640131016162 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 640131016163 substrate binding site [chemical binding]; other site 640131016164 THF binding site; other site 640131016165 zinc-binding site [ion binding]; other site 640131016166 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 640131016167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016168 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 640131016169 putative dimerization interface [polypeptide binding]; other site 640131016170 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 640131016171 EamA-like transporter family; Region: EamA; pfam00892 640131016172 putative hydrolase; Provisional; Region: PRK10976 640131016173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131016174 active site 640131016175 motif I; other site 640131016176 motif II; other site 640131016177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131016178 lysophospholipase L2; Provisional; Region: PRK10749 640131016179 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 640131016180 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 640131016181 putative transposase; Provisional; Region: PRK09857 640131016182 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 640131016183 threonine efflux system; Provisional; Region: PRK10229 640131016184 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 640131016185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131016186 ATP binding site [chemical binding]; other site 640131016187 putative Mg++ binding site [ion binding]; other site 640131016188 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131016189 nucleotide binding region [chemical binding]; other site 640131016190 ATP-binding site [chemical binding]; other site 640131016191 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 640131016192 HRDC domain; Region: HRDC; pfam00570 640131016193 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 640131016194 dimerization interface [polypeptide binding]; other site 640131016195 substrate binding site [chemical binding]; other site 640131016196 active site 640131016197 calcium binding site [ion binding]; other site 640131016198 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 640131016199 CoenzymeA binding site [chemical binding]; other site 640131016200 subunit interaction site [polypeptide binding]; other site 640131016201 PHB binding site; other site 640131016202 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 640131016203 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 640131016204 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 640131016205 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 640131016206 Cl binding site [ion binding]; other site 640131016207 oligomer interface [polypeptide binding]; other site 640131016208 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 640131016209 Part of AAA domain; Region: AAA_19; pfam13245 640131016210 Family description; Region: UvrD_C_2; pfam13538 640131016211 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 640131016212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131016213 motif II; other site 640131016214 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 640131016215 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 640131016216 active site 640131016217 Int/Topo IB signature motif; other site 640131016218 hypothetical protein; Provisional; Region: PRK10963 640131016219 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 640131016220 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 640131016221 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 640131016222 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 640131016223 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 640131016224 putative iron binding site [ion binding]; other site 640131016225 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 640131016226 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 640131016227 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 640131016228 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 640131016229 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 640131016230 domain interfaces; other site 640131016231 active site 640131016232 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 640131016233 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 640131016234 active site 640131016235 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 640131016236 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 640131016237 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 640131016238 HemY protein N-terminus; Region: HemY_N; pfam07219 640131016239 putative transport protein YifK; Provisional; Region: PRK10746 640131016240 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 640131016241 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 640131016242 putative common antigen polymerase; Provisional; Region: PRK02975 640131016243 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 640131016244 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 640131016245 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 640131016246 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 640131016247 inhibitor-cofactor binding pocket; inhibition site 640131016248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131016249 catalytic residue [active] 640131016250 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 640131016251 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 640131016252 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 640131016253 substrate binding site; other site 640131016254 tetramer interface; other site 640131016255 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 640131016256 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 640131016257 NAD binding site [chemical binding]; other site 640131016258 substrate binding site [chemical binding]; other site 640131016259 homodimer interface [polypeptide binding]; other site 640131016260 active site 640131016261 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 640131016262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 640131016263 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 640131016264 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 640131016265 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 640131016266 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 640131016267 homodimer interface [polypeptide binding]; other site 640131016268 active site 640131016269 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 640131016270 Chain length determinant protein; Region: Wzz; pfam02706 640131016271 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 640131016272 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 640131016273 Mg++ binding site [ion binding]; other site 640131016274 putative catalytic motif [active] 640131016275 substrate binding site [chemical binding]; other site 640131016276 transcription termination factor Rho; Provisional; Region: rho; PRK09376 640131016277 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 640131016278 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 640131016279 RNA binding site [nucleotide binding]; other site 640131016280 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 640131016281 multimer interface [polypeptide binding]; other site 640131016282 Walker A motif; other site 640131016283 ATP binding site [chemical binding]; other site 640131016284 Walker B motif; other site 640131016285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 640131016286 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 640131016287 catalytic residues [active] 640131016288 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 640131016289 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 640131016290 ATP binding site [chemical binding]; other site 640131016291 Mg++ binding site [ion binding]; other site 640131016292 motif III; other site 640131016293 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 640131016294 nucleotide binding region [chemical binding]; other site 640131016295 ATP-binding site [chemical binding]; other site 640131016296 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 640131016297 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 640131016298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 640131016299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016300 The C-terminal substrate binding domain of LysR-type transcriptional regulators that are involved in the catabolism of dinitrotoluene, naphthalene and gamma-hexachlorohexane; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_NahR_LinR_like; cd08459 640131016301 substrate binding pocket [chemical binding]; other site 640131016302 dimerization interface [polypeptide binding]; other site 640131016303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 640131016304 Protein of unknown function (DUF554); Region: DUF554; pfam04474 640131016305 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 640131016306 Part of AAA domain; Region: AAA_19; pfam13245 640131016307 Family description; Region: UvrD_C_2; pfam13538 640131016308 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 640131016309 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 640131016310 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 640131016311 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 640131016312 ketol-acid reductoisomerase; Validated; Region: PRK05225 640131016313 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 640131016314 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 640131016315 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 640131016316 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016317 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 640131016318 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 640131016319 putative dimerization interface [polypeptide binding]; other site 640131016320 threonine dehydratase; Reviewed; Region: PRK09224 640131016321 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 640131016322 tetramer interface [polypeptide binding]; other site 640131016323 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131016324 catalytic residue [active] 640131016325 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 640131016326 putative Ile/Val binding site [chemical binding]; other site 640131016327 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 640131016328 putative Ile/Val binding site [chemical binding]; other site 640131016329 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 640131016330 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 640131016331 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 640131016332 homodimer interface [polypeptide binding]; other site 640131016333 substrate-cofactor binding pocket; other site 640131016334 catalytic residue [active] 640131016335 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 640131016336 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 640131016337 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 640131016338 PYR/PP interface [polypeptide binding]; other site 640131016339 dimer interface [polypeptide binding]; other site 640131016340 TPP binding site [chemical binding]; other site 640131016341 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 640131016342 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 640131016343 TPP-binding site [chemical binding]; other site 640131016344 dimer interface [polypeptide binding]; other site 640131016345 putative ATP-dependent protease; Provisional; Region: PRK09862 640131016346 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 640131016347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131016348 Walker A motif; other site 640131016349 ATP binding site [chemical binding]; other site 640131016350 Walker B motif; other site 640131016351 arginine finger; other site 640131016352 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 640131016353 hypothetical protein; Provisional; Region: PRK11027 640131016354 transcriptional regulator HdfR; Provisional; Region: PRK03601 640131016355 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016356 LysR substrate binding domain; Region: LysR_substrate; pfam03466 640131016357 glutamate racemase; Provisional; Region: PRK00865 640131016358 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 640131016359 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 640131016360 N-terminal plug; other site 640131016361 ligand-binding site [chemical binding]; other site 640131016362 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 640131016363 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131016364 S-adenosylmethionine binding site [chemical binding]; other site 640131016365 hypothetical protein; Provisional; Region: PRK11056 640131016366 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 640131016367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 640131016368 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 640131016369 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 640131016370 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 640131016371 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 640131016372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016373 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 640131016374 dimerization interface [polypeptide binding]; other site 640131016375 argininosuccinate lyase; Provisional; Region: PRK04833 640131016376 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 640131016377 active sites [active] 640131016378 tetramer interface [polypeptide binding]; other site 640131016379 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 640131016380 nucleotide binding site [chemical binding]; other site 640131016381 N-acetyl-L-glutamate binding site [chemical binding]; other site 640131016382 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 640131016383 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 640131016384 acetylornithine deacetylase; Provisional; Region: PRK05111 640131016385 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 640131016386 metal binding site [ion binding]; metal-binding site 640131016387 putative dimer interface [polypeptide binding]; other site 640131016388 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 640131016389 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 640131016390 zinc/cadmium-binding protein; Provisional; Region: PRK10306 640131016391 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 640131016392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131016393 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 640131016394 active site 640131016395 intersubunit interactions; other site 640131016396 catalytic residue [active] 640131016397 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 640131016398 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 640131016399 dimer interface [polypeptide binding]; other site 640131016400 active site 640131016401 metal binding site [ion binding]; metal-binding site 640131016402 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 640131016403 FAD binding site [chemical binding]; other site 640131016404 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 640131016405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016406 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 640131016407 dimerization interface [polypeptide binding]; other site 640131016408 substrate binding pocket [chemical binding]; other site 640131016409 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 640131016410 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 640131016411 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 640131016412 putative catalytic residues [active] 640131016413 putative nucleotide binding site [chemical binding]; other site 640131016414 putative aspartate binding site [chemical binding]; other site 640131016415 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 640131016416 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 640131016417 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 640131016418 cystathionine gamma-synthase; Provisional; Region: PRK08045 640131016419 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 640131016420 homodimer interface [polypeptide binding]; other site 640131016421 substrate-cofactor binding pocket; other site 640131016422 pyridoxal 5'-phosphate binding site [chemical binding]; other site 640131016423 catalytic residue [active] 640131016424 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 640131016425 dimerization interface [polypeptide binding]; other site 640131016426 DNA binding site [nucleotide binding] 640131016427 corepressor binding sites; other site 640131016428 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 640131016429 primosome assembly protein PriA; Validated; Region: PRK05580 640131016430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 640131016431 ATP binding site [chemical binding]; other site 640131016432 putative Mg++ binding site [ion binding]; other site 640131016433 helicase superfamily c-terminal domain; Region: HELICc; smart00490 640131016434 ATP-binding site [chemical binding]; other site 640131016435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131016436 DNA binding site [nucleotide binding] 640131016437 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 640131016438 domain linker motif; other site 640131016439 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 640131016440 dimerization interface [polypeptide binding]; other site 640131016441 ligand binding site [chemical binding]; other site 640131016442 cell division protein FtsN; Provisional; Region: PRK12757 640131016443 Sporulation related domain; Region: SPOR; cl10051 640131016444 Sporulation related domain; Region: SPOR; cl10051 640131016445 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 640131016446 active site 640131016447 HslU subunit interaction site [polypeptide binding]; other site 640131016448 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 640131016449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131016450 Walker A motif; other site 640131016451 ATP binding site [chemical binding]; other site 640131016452 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 640131016453 Walker B motif; other site 640131016454 arginine finger; other site 640131016455 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 640131016456 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 640131016457 UbiA prenyltransferase family; Region: UbiA; pfam01040 640131016458 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 640131016459 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 640131016460 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 640131016461 active site 640131016462 ADP/pyrophosphate binding site [chemical binding]; other site 640131016463 dimerization interface [polypeptide binding]; other site 640131016464 allosteric effector site; other site 640131016465 fructose-1,6-bisphosphate binding site; other site 640131016466 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 640131016467 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 640131016468 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 640131016469 dimer interface [polypeptide binding]; other site 640131016470 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 640131016471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131016472 active site 640131016473 phosphorylation site [posttranslational modification] 640131016474 intermolecular recognition site; other site 640131016475 dimerization interface [polypeptide binding]; other site 640131016476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 640131016477 DNA binding site [nucleotide binding] 640131016478 two-component sensor protein; Provisional; Region: cpxA; PRK09470 640131016479 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 640131016480 dimerization interface [polypeptide binding]; other site 640131016481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131016482 dimer interface [polypeptide binding]; other site 640131016483 phosphorylation site [posttranslational modification] 640131016484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131016485 ATP binding site [chemical binding]; other site 640131016486 Mg2+ binding site [ion binding]; other site 640131016487 G-X-G motif; other site 640131016488 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 640131016489 MOSC domain; Region: MOSC; pfam03473 640131016490 3-alpha domain; Region: 3-alpha; pfam03475 640131016491 superoxide dismutase; Provisional; Region: PRK10925 640131016492 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 640131016493 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 640131016494 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 640131016495 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 640131016496 transcriptional activator RhaR; Provisional; Region: PRK13502 640131016497 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131016498 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131016499 transcriptional activator RhaS; Provisional; Region: PRK13503 640131016500 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 640131016501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131016502 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 640131016503 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 640131016504 N- and C-terminal domain interface [polypeptide binding]; other site 640131016505 active site 640131016506 putative catalytic site [active] 640131016507 metal binding site [ion binding]; metal-binding site 640131016508 ATP binding site [chemical binding]; other site 640131016509 rhamnulokinase; Provisional; Region: rhaB; PRK10640 640131016510 carbohydrate binding site [chemical binding]; other site 640131016511 L-rhamnose isomerase; Provisional; Region: PRK01076 640131016512 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 640131016513 intersubunit interface [polypeptide binding]; other site 640131016514 active site 640131016515 Zn2+ binding site [ion binding]; other site 640131016516 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 640131016517 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 640131016518 ligand binding site [chemical binding]; other site 640131016519 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 640131016520 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131016521 Walker A/P-loop; other site 640131016522 ATP binding site [chemical binding]; other site 640131016523 Q-loop/lid; other site 640131016524 ABC transporter signature motif; other site 640131016525 Walker B; other site 640131016526 D-loop; other site 640131016527 H-loop/switch region; other site 640131016528 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131016529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131016530 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131016531 TM-ABC transporter signature motif; other site 640131016532 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131016533 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131016534 TM-ABC transporter signature motif; other site 640131016535 lactaldehyde reductase; Region: lactal_redase; TIGR02638 640131016536 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 640131016537 dimer interface [polypeptide binding]; other site 640131016538 active site 640131016539 metal binding site [ion binding]; metal-binding site 640131016540 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 640131016541 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 640131016542 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 640131016543 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 640131016544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131016545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131016546 DNA binding site [nucleotide binding] 640131016547 domain linker motif; other site 640131016548 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 640131016549 dimerization interface [polypeptide binding]; other site 640131016550 ligand binding site [chemical binding]; other site 640131016551 galactoside permease; Reviewed; Region: lacY; PRK09528 640131016552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131016553 putative substrate translocation pore; other site 640131016554 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 640131016555 Melibiase; Region: Melibiase; pfam02065 640131016556 Transcriptional regulators [Transcription]; Region: PurR; COG1609 640131016557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131016558 DNA binding site [nucleotide binding] 640131016559 domain linker motif; other site 640131016560 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 640131016561 ligand binding site [chemical binding]; other site 640131016562 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 640131016563 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 640131016564 non-specific DNA binding site [nucleotide binding]; other site 640131016565 salt bridge; other site 640131016566 sequence-specific DNA binding site [nucleotide binding]; other site 640131016567 Cupin domain; Region: Cupin_2; cl17218 640131016568 AzlC protein; Region: AzlC; cl00570 640131016569 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 640131016570 AAA domain; Region: AAA_17; pfam13207 640131016571 AAA domain; Region: AAA_18; pfam13238 640131016572 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 640131016573 active site 640131016574 phosphorylation site [posttranslational modification] 640131016575 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 640131016576 intersubunit interface [polypeptide binding]; other site 640131016577 active site 640131016578 zinc binding site [ion binding]; other site 640131016579 Na+ binding site [ion binding]; other site 640131016580 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 640131016581 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 640131016582 active site 640131016583 P-loop; other site 640131016584 phosphorylation site [posttranslational modification] 640131016585 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 640131016586 dimerization interface [polypeptide binding]; other site 640131016587 allosteric effector site; other site 640131016588 active site 640131016589 ADP/pyrophosphate binding site [chemical binding]; other site 640131016590 fructose-1,6-bisphosphate binding site; other site 640131016591 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 640131016592 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131016593 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 640131016594 molybdopterin cofactor binding site; other site 640131016595 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 640131016596 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 640131016597 molybdopterin cofactor binding site; other site 640131016598 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 640131016599 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 640131016600 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 640131016601 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 640131016602 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 640131016603 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 640131016604 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 640131016605 oligomeric interface; other site 640131016606 putative active site [active] 640131016607 homodimer interface [polypeptide binding]; other site 640131016608 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 640131016609 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 640131016610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131016611 Coenzyme A binding pocket [chemical binding]; other site 640131016612 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 640131016613 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 640131016614 putative active site [active] 640131016615 dimerization interface [polypeptide binding]; other site 640131016616 putative tRNAtyr binding site [nucleotide binding]; other site 640131016617 hypothetical protein; Reviewed; Region: PRK01637 640131016618 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 640131016619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131016620 motif II; other site 640131016621 GTP-binding protein; Provisional; Region: PRK10218 640131016622 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 640131016623 G1 box; other site 640131016624 putative GEF interaction site [polypeptide binding]; other site 640131016625 GTP/Mg2+ binding site [chemical binding]; other site 640131016626 Switch I region; other site 640131016627 G2 box; other site 640131016628 G3 box; other site 640131016629 Switch II region; other site 640131016630 G4 box; other site 640131016631 G5 box; other site 640131016632 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 640131016633 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 640131016634 glutamine synthetase; Provisional; Region: glnA; PRK09469 640131016635 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 640131016636 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 640131016637 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 640131016638 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 640131016639 putative active site [active] 640131016640 heme pocket [chemical binding]; other site 640131016641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 640131016642 dimer interface [polypeptide binding]; other site 640131016643 phosphorylation site [posttranslational modification] 640131016644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 640131016645 ATP binding site [chemical binding]; other site 640131016646 Mg2+ binding site [ion binding]; other site 640131016647 G-X-G motif; other site 640131016648 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 640131016649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 640131016650 active site 640131016651 phosphorylation site [posttranslational modification] 640131016652 intermolecular recognition site; other site 640131016653 dimerization interface [polypeptide binding]; other site 640131016654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131016655 Walker A motif; other site 640131016656 ATP binding site [chemical binding]; other site 640131016657 Walker B motif; other site 640131016658 arginine finger; other site 640131016659 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 640131016660 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 640131016661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 640131016662 FeS/SAM binding site; other site 640131016663 HemN C-terminal domain; Region: HemN_C; pfam06969 640131016664 Der GTPase activator; Provisional; Region: PRK05244 640131016665 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 640131016666 G1 box; other site 640131016667 GTP/Mg2+ binding site [chemical binding]; other site 640131016668 Switch I region; other site 640131016669 G2 box; other site 640131016670 G3 box; other site 640131016671 Switch II region; other site 640131016672 G4 box; other site 640131016673 G5 box; other site 640131016674 DNA polymerase I; Provisional; Region: PRK05755 640131016675 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 640131016676 active site 640131016677 metal binding site 1 [ion binding]; metal-binding site 640131016678 putative 5' ssDNA interaction site; other site 640131016679 metal binding site 3; metal-binding site 640131016680 metal binding site 2 [ion binding]; metal-binding site 640131016681 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 640131016682 putative DNA binding site [nucleotide binding]; other site 640131016683 putative metal binding site [ion binding]; other site 640131016684 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 640131016685 active site 640131016686 catalytic site [active] 640131016687 substrate binding site [chemical binding]; other site 640131016688 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 640131016689 active site 640131016690 DNA binding site [nucleotide binding] 640131016691 catalytic site [active] 640131016692 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 640131016693 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 640131016694 putative acyl-acceptor binding pocket; other site 640131016695 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 640131016696 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 640131016697 catalytic residues [active] 640131016698 hinge region; other site 640131016699 alpha helical domain; other site 640131016700 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 640131016701 serine/threonine protein kinase; Provisional; Region: PRK11768 640131016702 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 640131016703 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 640131016704 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 640131016705 GTP binding site; other site 640131016706 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 640131016707 Walker A motif; other site 640131016708 Transcriptional regulators [Transcription]; Region: GntR; COG1802 640131016709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 640131016710 DNA-binding site [nucleotide binding]; DNA binding site 640131016711 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 640131016712 putative transporter; Provisional; Region: PRK10504 640131016713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131016714 putative substrate translocation pore; other site 640131016715 transcriptional repressor RbsR; Provisional; Region: PRK10423 640131016716 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 640131016717 DNA binding site [nucleotide binding] 640131016718 domain linker motif; other site 640131016719 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 640131016720 dimerization interface [polypeptide binding]; other site 640131016721 ligand binding site [chemical binding]; other site 640131016722 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 640131016723 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 640131016724 substrate binding site [chemical binding]; other site 640131016725 dimer interface [polypeptide binding]; other site 640131016726 ATP binding site [chemical binding]; other site 640131016727 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 640131016728 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 640131016729 ligand binding site [chemical binding]; other site 640131016730 dimerization interface [polypeptide binding]; other site 640131016731 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 640131016732 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 640131016733 TM-ABC transporter signature motif; other site 640131016734 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 640131016735 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 640131016736 Walker A/P-loop; other site 640131016737 ATP binding site [chemical binding]; other site 640131016738 Q-loop/lid; other site 640131016739 ABC transporter signature motif; other site 640131016740 Walker B; other site 640131016741 D-loop; other site 640131016742 H-loop/switch region; other site 640131016743 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 640131016744 D-ribose pyranase; Provisional; Region: PRK11797 640131016745 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 640131016746 potassium uptake protein; Region: kup; TIGR00794 640131016747 regulatory ATPase RavA; Provisional; Region: PRK13531 640131016748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 640131016749 Walker A motif; other site 640131016750 ATP binding site [chemical binding]; other site 640131016751 Walker B motif; other site 640131016752 arginine finger; other site 640131016753 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 640131016754 hypothetical protein; Provisional; Region: yieM; PRK10997 640131016755 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 640131016756 metal ion-dependent adhesion site (MIDAS); other site 640131016757 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 640131016758 dimer interface [polypeptide binding]; other site 640131016759 active site 640131016760 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 640131016761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 640131016762 putative DNA binding site [nucleotide binding]; other site 640131016763 putative Zn2+ binding site [ion binding]; other site 640131016764 AsnC family; Region: AsnC_trans_reg; pfam01037 640131016765 FMN-binding protein MioC; Provisional; Region: PRK09004 640131016766 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 640131016767 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 640131016768 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 640131016769 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 640131016770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 640131016771 S-adenosylmethionine binding site [chemical binding]; other site 640131016772 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 640131016773 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 640131016774 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 640131016775 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 640131016776 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 640131016777 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 640131016778 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 640131016779 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 640131016780 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 640131016781 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 640131016782 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 640131016783 beta subunit interaction interface [polypeptide binding]; other site 640131016784 Walker A motif; other site 640131016785 ATP binding site [chemical binding]; other site 640131016786 Walker B motif; other site 640131016787 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 640131016788 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 640131016789 core domain interface [polypeptide binding]; other site 640131016790 delta subunit interface [polypeptide binding]; other site 640131016791 epsilon subunit interface [polypeptide binding]; other site 640131016792 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 640131016793 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 640131016794 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 640131016795 alpha subunit interaction interface [polypeptide binding]; other site 640131016796 Walker A motif; other site 640131016797 ATP binding site [chemical binding]; other site 640131016798 Walker B motif; other site 640131016799 inhibitor binding site; inhibition site 640131016800 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 640131016801 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 640131016802 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 640131016803 gamma subunit interface [polypeptide binding]; other site 640131016804 epsilon subunit interface [polypeptide binding]; other site 640131016805 LBP interface [polypeptide binding]; other site 640131016806 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 640131016807 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 640131016808 Substrate binding site; other site 640131016809 Mg++ binding site; other site 640131016810 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 640131016811 active site 640131016812 substrate binding site [chemical binding]; other site 640131016813 CoA binding site [chemical binding]; other site 640131016814 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 640131016815 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 640131016816 glutaminase active site [active] 640131016817 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 640131016818 dimer interface [polypeptide binding]; other site 640131016819 active site 640131016820 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 640131016821 dimer interface [polypeptide binding]; other site 640131016822 active site 640131016823 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 640131016824 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 640131016825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131016826 dimer interface [polypeptide binding]; other site 640131016827 conserved gate region; other site 640131016828 putative PBP binding loops; other site 640131016829 ABC-ATPase subunit interface; other site 640131016830 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 640131016831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 640131016832 dimer interface [polypeptide binding]; other site 640131016833 conserved gate region; other site 640131016834 putative PBP binding loops; other site 640131016835 ABC-ATPase subunit interface; other site 640131016836 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 640131016837 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 640131016838 Walker A/P-loop; other site 640131016839 ATP binding site [chemical binding]; other site 640131016840 Q-loop/lid; other site 640131016841 ABC transporter signature motif; other site 640131016842 Walker B; other site 640131016843 D-loop; other site 640131016844 H-loop/switch region; other site 640131016845 transcriptional regulator PhoU; Provisional; Region: PRK11115 640131016846 PhoU domain; Region: PhoU; pfam01895 640131016847 PhoU domain; Region: PhoU; pfam01895 640131016848 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 640131016849 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 640131016850 trimer interface; other site 640131016851 sugar binding site [chemical binding]; other site 640131016852 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 640131016853 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 640131016854 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 640131016855 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 640131016856 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 640131016857 active site 640131016858 trimer interface [polypeptide binding]; other site 640131016859 allosteric site; other site 640131016860 active site lid [active] 640131016861 hexamer (dimer of trimers) interface [polypeptide binding]; other site 640131016862 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 640131016863 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 640131016864 active site 640131016865 motif I; other site 640131016866 motif II; other site 640131016867 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 640131016868 Predicted flavoprotein [General function prediction only]; Region: COG0431 640131016869 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 640131016870 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 640131016871 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 640131016872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 640131016873 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 640131016874 substrate binding pocket [chemical binding]; other site 640131016875 dimerization interface [polypeptide binding]; other site 640131016876 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 640131016877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 640131016878 putative substrate translocation pore; other site 640131016879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 640131016880 Coenzyme A binding pocket [chemical binding]; other site 640131016881 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 640131016882 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 640131016883 trmE is a tRNA modification GTPase; Region: trmE; cd04164 640131016884 G1 box; other site 640131016885 GTP/Mg2+ binding site [chemical binding]; other site 640131016886 Switch I region; other site 640131016887 G2 box; other site 640131016888 Switch II region; other site 640131016889 G3 box; other site 640131016890 G4 box; other site 640131016891 G5 box; other site 640131016892 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631