-- dump date 20140619_121829 -- class Genbank::misc_feature -- table misc_feature_note -- id note 378753000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 378753000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753000003 Walker A motif; other site 378753000004 ATP binding site [chemical binding]; other site 378753000005 Walker B motif; other site 378753000006 arginine finger; other site 378753000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 378753000008 DnaA box-binding interface [nucleotide binding]; other site 378753000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 378753000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 378753000011 putative DNA binding surface [nucleotide binding]; other site 378753000012 dimer interface [polypeptide binding]; other site 378753000013 beta-clamp/clamp loader binding surface; other site 378753000014 beta-clamp/translesion DNA polymerase binding surface; other site 378753000015 recombination protein F; Reviewed; Region: recF; PRK00064 378753000016 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 378753000017 Walker A/P-loop; other site 378753000018 ATP binding site [chemical binding]; other site 378753000019 Q-loop/lid; other site 378753000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753000021 ABC transporter signature motif; other site 378753000022 Walker B; other site 378753000023 D-loop; other site 378753000024 H-loop/switch region; other site 378753000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 378753000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 378753000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753000028 Mg2+ binding site [ion binding]; other site 378753000029 G-X-G motif; other site 378753000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 378753000031 anchoring element; other site 378753000032 dimer interface [polypeptide binding]; other site 378753000033 ATP binding site [chemical binding]; other site 378753000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 378753000035 active site 378753000036 metal binding site [ion binding]; metal-binding site 378753000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 378753000038 DNA gyrase subunit A; Validated; Region: PRK05560 378753000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 378753000040 CAP-like domain; other site 378753000041 active site 378753000042 primary dimer interface [polypeptide binding]; other site 378753000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 378753000050 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 378753000051 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 378753000052 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 378753000053 active site 378753000054 Rhomboid family; Region: Rhomboid; pfam01694 378753000055 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 378753000056 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000057 putative substrate translocation pore; other site 378753000058 Putative esterase; Region: Esterase; pfam00756 378753000059 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 378753000060 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 378753000061 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 378753000062 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378753000063 putative NAD(P) binding site [chemical binding]; other site 378753000064 catalytic Zn binding site [ion binding]; other site 378753000065 H+ Antiporter protein; Region: 2A0121; TIGR00900 378753000066 H+ Antiporter protein; Region: 2A0121; TIGR00900 378753000067 thiamine pyrophosphate protein; Validated; Region: PRK08199 378753000068 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378753000069 PYR/PP interface [polypeptide binding]; other site 378753000070 dimer interface [polypeptide binding]; other site 378753000071 TPP binding site [chemical binding]; other site 378753000072 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378753000073 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 378753000074 TPP-binding site [chemical binding]; other site 378753000075 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 378753000076 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000077 putative substrate translocation pore; other site 378753000078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000079 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378753000080 MarR family; Region: MarR_2; pfam12802 378753000081 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 378753000082 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 378753000083 nucleotide binding site [chemical binding]; other site 378753000084 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 378753000085 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 378753000086 active site 378753000087 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000088 Ligand Binding Site [chemical binding]; other site 378753000089 amino acid transporter; Region: 2A0306; TIGR00909 378753000090 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 378753000091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000092 POT family; Region: PTR2; cl17359 378753000093 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 378753000094 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378753000095 active site 378753000096 catalytic tetrad [active] 378753000097 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753000098 MarR family; Region: MarR; pfam01047 378753000099 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 378753000100 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 378753000101 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753000102 Walker A/P-loop; other site 378753000103 ATP binding site [chemical binding]; other site 378753000104 Q-loop/lid; other site 378753000105 ABC transporter signature motif; other site 378753000106 Walker B; other site 378753000107 D-loop; other site 378753000108 H-loop/switch region; other site 378753000109 Predicted membrane protein [Function unknown]; Region: COG2323 378753000110 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 378753000111 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 378753000112 Walker A/P-loop; other site 378753000113 ATP binding site [chemical binding]; other site 378753000114 Q-loop/lid; other site 378753000115 ABC transporter signature motif; other site 378753000116 Walker B; other site 378753000117 D-loop; other site 378753000118 H-loop/switch region; other site 378753000119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753000120 dimer interface [polypeptide binding]; other site 378753000121 conserved gate region; other site 378753000122 putative PBP binding loops; other site 378753000123 ABC-ATPase subunit interface; other site 378753000124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753000125 ABC-ATPase subunit interface; other site 378753000126 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 378753000127 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 378753000128 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 378753000129 hydrophobic ligand binding site; other site 378753000130 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 378753000131 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 378753000132 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 378753000133 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 378753000134 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 378753000135 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 378753000136 dimerization interface [polypeptide binding]; other site 378753000137 ligand binding site [chemical binding]; other site 378753000138 NADP binding site [chemical binding]; other site 378753000139 catalytic site [active] 378753000140 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 378753000141 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 378753000142 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753000143 catalytic residue [active] 378753000144 Cupin domain; Region: Cupin_2; cl17218 378753000145 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 378753000146 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 378753000147 dimerization interface [polypeptide binding]; other site 378753000148 active site 378753000149 L-aspartate oxidase; Region: nadB; TIGR00551 378753000150 L-aspartate oxidase; Provisional; Region: PRK06175 378753000151 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 378753000152 quinolinate synthetase; Provisional; Region: PRK09375 378753000153 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 378753000154 nudix motif; other site 378753000155 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 378753000156 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 378753000157 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 378753000158 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 378753000159 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 378753000160 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 378753000161 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 378753000162 FAD dependent oxidoreductase; Region: DAO; pfam01266 378753000163 hydroxyglutarate oxidase; Provisional; Region: PRK11728 378753000164 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 378753000165 proposed catalytic triad [active] 378753000166 conserved cys residue [active] 378753000167 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 378753000168 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 378753000169 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 378753000170 calcium binding site 2 [ion binding]; other site 378753000171 active site 378753000172 catalytic triad [active] 378753000173 calcium binding site 1 [ion binding]; other site 378753000174 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 378753000175 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 378753000176 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 378753000177 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 378753000178 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 378753000179 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 378753000180 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 378753000181 arsenical-resistance protein; Region: acr3; TIGR00832 378753000182 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 378753000183 active site 378753000184 metal binding site [ion binding]; metal-binding site 378753000185 homotetramer interface [polypeptide binding]; other site 378753000186 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 378753000187 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378753000188 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 378753000189 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 378753000190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753000192 putative substrate translocation pore; other site 378753000193 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753000194 allantoate amidohydrolase; Reviewed; Region: PRK09290 378753000195 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 378753000196 active site 378753000197 metal binding site [ion binding]; metal-binding site 378753000198 dimer interface [polypeptide binding]; other site 378753000199 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 378753000200 CoA-transferase family III; Region: CoA_transf_3; pfam02515 378753000201 acyl-coenzyme A oxidase; Region: PLN02526 378753000202 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753000203 active site 378753000204 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 378753000205 Uncharacterized conserved protein [Function unknown]; Region: COG1359 378753000206 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753000207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000208 putative substrate translocation pore; other site 378753000209 CsbD-like; Region: CsbD; cl17424 378753000210 Protein of unknown function, DUF488; Region: DUF488; cl01246 378753000211 Pirin-related protein [General function prediction only]; Region: COG1741 378753000212 Pirin; Region: Pirin; pfam02678 378753000213 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 378753000214 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 378753000215 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 378753000216 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 378753000217 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 378753000218 tetrameric interface [polypeptide binding]; other site 378753000219 NAD binding site [chemical binding]; other site 378753000220 catalytic residues [active] 378753000221 substrate binding site [chemical binding]; other site 378753000222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753000223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000224 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 378753000225 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753000226 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 378753000227 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000228 Ligand Binding Site [chemical binding]; other site 378753000229 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000230 Ligand Binding Site [chemical binding]; other site 378753000231 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 378753000232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753000233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000234 putative transporter; Provisional; Region: PRK11021 378753000235 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378753000236 RNA binding surface [nucleotide binding]; other site 378753000237 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378753000238 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753000239 DNA-binding site [nucleotide binding]; DNA binding site 378753000240 FCD domain; Region: FCD; pfam07729 378753000241 ethanolamine permease; Region: 2A0305; TIGR00908 378753000242 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 378753000243 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 378753000244 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 378753000245 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 378753000246 catalytic triad [active] 378753000247 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 378753000248 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753000249 NAD(P) binding site [chemical binding]; other site 378753000250 catalytic residues [active] 378753000251 short chain dehydrogenase; Provisional; Region: PRK06057 378753000252 classical (c) SDRs; Region: SDR_c; cd05233 378753000253 NAD(P) binding site [chemical binding]; other site 378753000254 active site 378753000255 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 378753000256 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 378753000257 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 378753000258 H+ Antiporter protein; Region: 2A0121; TIGR00900 378753000259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000260 putative substrate translocation pore; other site 378753000261 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 378753000262 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 378753000263 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000264 Ligand Binding Site [chemical binding]; other site 378753000265 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000266 Ligand Binding Site [chemical binding]; other site 378753000267 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000268 Ligand Binding Site [chemical binding]; other site 378753000269 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000270 Ligand Binding Site [chemical binding]; other site 378753000271 Repair protein; Region: Repair_PSII; pfam04536 378753000272 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 378753000273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753000274 Walker A/P-loop; other site 378753000275 ATP binding site [chemical binding]; other site 378753000276 Q-loop/lid; other site 378753000277 ABC transporter signature motif; other site 378753000278 Walker B; other site 378753000279 D-loop; other site 378753000280 H-loop/switch region; other site 378753000281 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 378753000282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753000283 dimer interface [polypeptide binding]; other site 378753000284 conserved gate region; other site 378753000285 putative PBP binding loops; other site 378753000286 ABC-ATPase subunit interface; other site 378753000287 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 378753000288 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 378753000289 substrate binding pocket [chemical binding]; other site 378753000290 membrane-bound complex binding site; other site 378753000291 hinge residues; other site 378753000292 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 378753000293 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753000294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753000295 catalytic residue [active] 378753000296 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 378753000297 imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; Region: IMP_synth_hisH; TIGR01855 378753000298 predicted active site [active] 378753000299 catalytic triad [active] 378753000300 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 378753000301 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 378753000302 active site 378753000303 multimer interface [polypeptide binding]; other site 378753000304 Mitochondrial ribosomal death-associated protein 3; Region: DAP3; pfam10236 378753000305 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 378753000306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753000307 DNA-binding site [nucleotide binding]; DNA binding site 378753000308 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753000309 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753000310 catalytic residue [active] 378753000311 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 378753000312 metal-binding site [ion binding] 378753000313 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 378753000314 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378753000315 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 378753000316 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 378753000317 metal-binding site [ion binding] 378753000318 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 378753000319 putative homodimer interface [polypeptide binding]; other site 378753000320 putative homotetramer interface [polypeptide binding]; other site 378753000321 putative allosteric switch controlling residues; other site 378753000322 putative metal binding site [ion binding]; other site 378753000323 putative homodimer-homodimer interface [polypeptide binding]; other site 378753000324 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753000325 MarR family; Region: MarR; pfam01047 378753000326 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 378753000327 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 378753000328 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 378753000329 FeoA domain; Region: FeoA; pfam04023 378753000330 active site 378753000331 metal binding site [ion binding]; metal-binding site 378753000332 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 378753000333 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 378753000334 CGNR zinc finger; Region: zf-CGNR; pfam11706 378753000335 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 378753000336 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 378753000337 ABC-ATPase subunit interface; other site 378753000338 dimer interface [polypeptide binding]; other site 378753000339 putative PBP binding regions; other site 378753000340 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 378753000341 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 378753000342 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 378753000343 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 378753000344 metal binding site [ion binding]; metal-binding site 378753000345 Protein of unknown function (DUF805); Region: DUF805; pfam05656 378753000346 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 378753000347 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 378753000348 Proline dehydrogenase; Region: Pro_dh; cl03282 378753000349 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 378753000350 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753000351 Glutamate binding site [chemical binding]; other site 378753000352 NAD binding site [chemical binding]; other site 378753000353 catalytic residues [active] 378753000354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 378753000355 putative dimer interface [polypeptide binding]; other site 378753000356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 378753000357 ligand binding site [chemical binding]; other site 378753000358 Zn binding site [ion binding]; other site 378753000359 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753000360 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 378753000361 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 378753000362 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 378753000363 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 378753000364 metal ion-dependent adhesion site (MIDAS); other site 378753000365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 378753000366 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 378753000367 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 378753000368 NAD binding site [chemical binding]; other site 378753000369 catalytic Zn binding site [ion binding]; other site 378753000370 structural Zn binding site [ion binding]; other site 378753000371 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 378753000372 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 378753000373 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 378753000374 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753000375 Walker A/P-loop; other site 378753000376 ATP binding site [chemical binding]; other site 378753000377 Q-loop/lid; other site 378753000378 ABC transporter signature motif; other site 378753000379 Walker B; other site 378753000380 D-loop; other site 378753000381 H-loop/switch region; other site 378753000382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753000383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000384 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 378753000385 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 378753000386 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 378753000387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000388 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753000389 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 378753000390 xanthine permease; Region: pbuX; TIGR03173 378753000391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753000392 active site 378753000393 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 378753000394 propionate/acetate kinase; Provisional; Region: PRK12379 378753000395 phosphate acetyltransferase; Reviewed; Region: PRK05632 378753000396 DRTGG domain; Region: DRTGG; pfam07085 378753000397 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 378753000398 Domain of unknown function DUF77; Region: DUF77; pfam01910 378753000399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753000400 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 378753000401 ferredoxin-NADP+ reductase; Region: PLN02852 378753000402 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753000403 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 378753000404 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 378753000405 active site 378753000406 dimer interface [polypeptide binding]; other site 378753000407 non-prolyl cis peptide bond; other site 378753000408 insertion regions; other site 378753000409 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 378753000410 FAD binding domain; Region: FAD_binding_4; pfam01565 378753000411 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 378753000412 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000413 Ligand Binding Site [chemical binding]; other site 378753000414 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753000415 Ligand Binding Site [chemical binding]; other site 378753000416 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 378753000417 active site 378753000418 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 378753000419 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 378753000420 active site 378753000421 catalytic site [active] 378753000422 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 378753000423 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 378753000424 putative catalytic site [active] 378753000425 putative phosphate binding site [ion binding]; other site 378753000426 active site 378753000427 metal binding site A [ion binding]; metal-binding site 378753000428 DNA binding site [nucleotide binding] 378753000429 putative AP binding site [nucleotide binding]; other site 378753000430 putative metal binding site B [ion binding]; other site 378753000431 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 378753000432 PLD-like domain; Region: PLDc_2; pfam13091 378753000433 putative active site [active] 378753000434 catalytic site [active] 378753000435 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 378753000436 PLD-like domain; Region: PLDc_2; pfam13091 378753000437 putative active site [active] 378753000438 catalytic site [active] 378753000439 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 378753000440 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 378753000441 active site 378753000442 non-prolyl cis peptide bond; other site 378753000443 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 378753000444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753000445 NAD(P) binding site [chemical binding]; other site 378753000446 active site 378753000447 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 378753000448 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 378753000449 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 378753000450 homodimer interface [polypeptide binding]; other site 378753000451 NAD binding pocket [chemical binding]; other site 378753000452 ATP binding pocket [chemical binding]; other site 378753000453 Mg binding site [ion binding]; other site 378753000454 active-site loop [active] 378753000455 enoyl-CoA hydratase; Provisional; Region: PRK05862 378753000456 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753000457 substrate binding site [chemical binding]; other site 378753000458 oxyanion hole (OAH) forming residues; other site 378753000459 trimer interface [polypeptide binding]; other site 378753000460 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 378753000461 DNA binding residues [nucleotide binding] 378753000462 TOBE domain; Region: TOBE; cl01440 378753000463 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 378753000464 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 378753000465 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 378753000466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753000467 dimer interface [polypeptide binding]; other site 378753000468 conserved gate region; other site 378753000469 putative PBP binding loops; other site 378753000470 ABC-ATPase subunit interface; other site 378753000471 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 378753000472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753000473 Walker A/P-loop; other site 378753000474 ATP binding site [chemical binding]; other site 378753000475 Q-loop/lid; other site 378753000476 ABC transporter signature motif; other site 378753000477 Walker B; other site 378753000478 D-loop; other site 378753000479 H-loop/switch region; other site 378753000480 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 378753000481 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 378753000482 Walker A/P-loop; other site 378753000483 ATP binding site [chemical binding]; other site 378753000484 Q-loop/lid; other site 378753000485 ABC transporter signature motif; other site 378753000486 Walker B; other site 378753000487 D-loop; other site 378753000488 H-loop/switch region; other site 378753000489 Uncharacterized conserved protein [Function unknown]; Region: COG1359 378753000490 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 378753000491 Predicted permease; Region: DUF318; cl17795 378753000492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753000493 Coenzyme A binding pocket [chemical binding]; other site 378753000494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 378753000495 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 378753000496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753000497 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 378753000498 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753000499 acyl-activating enzyme (AAE) consensus motif; other site 378753000500 AMP binding site [chemical binding]; other site 378753000501 active site 378753000502 CoA binding site [chemical binding]; other site 378753000503 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 378753000504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753000505 NAD(P) binding site [chemical binding]; other site 378753000506 active site 378753000507 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378753000508 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 378753000509 putative NAD(P) binding site [chemical binding]; other site 378753000510 EamA-like transporter family; Region: EamA; cl17759 378753000511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000512 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 378753000513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000514 putative substrate translocation pore; other site 378753000515 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 378753000516 thymidine kinase; Provisional; Region: PRK04296 378753000517 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753000518 active site 378753000519 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 378753000520 Secretory lipase; Region: LIP; pfam03583 378753000521 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 378753000522 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 378753000523 active site 378753000524 intersubunit interface [polypeptide binding]; other site 378753000525 zinc binding site [ion binding]; other site 378753000526 Na+ binding site [ion binding]; other site 378753000527 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 378753000528 amidohydrolase; Region: amidohydrolases; TIGR01891 378753000529 metal binding site [ion binding]; metal-binding site 378753000530 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 378753000531 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 378753000532 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 378753000533 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 378753000534 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 378753000535 hexamer interface [polypeptide binding]; other site 378753000536 ligand binding site [chemical binding]; other site 378753000537 putative active site [active] 378753000538 NAD(P) binding site [chemical binding]; other site 378753000539 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 378753000540 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 378753000541 catalytic triad [active] 378753000542 putative active site [active] 378753000543 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 378753000544 PA/protease or protease-like domain interface [polypeptide binding]; other site 378753000545 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 378753000546 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 378753000547 S-layer homology domain; Region: SLH; pfam00395 378753000548 S-layer homology domain; Region: SLH; pfam00395 378753000549 S-layer homology domain; Region: SLH; pfam00395 378753000550 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 378753000551 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 378753000552 GDP-binding site [chemical binding]; other site 378753000553 ACT binding site; other site 378753000554 IMP binding site; other site 378753000555 lysine transporter; Provisional; Region: PRK10836 378753000556 Domain of unknown function (DUF202); Region: DUF202; pfam02656 378753000557 Domain of unknown function (DUF202); Region: DUF202; cl09954 378753000558 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 378753000559 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 378753000560 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 378753000561 active site 378753000562 Zn binding site [ion binding]; other site 378753000563 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 378753000564 enoyl-CoA hydratase; Provisional; Region: PRK06688 378753000565 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753000566 substrate binding site [chemical binding]; other site 378753000567 oxyanion hole (OAH) forming residues; other site 378753000568 trimer interface [polypeptide binding]; other site 378753000569 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 378753000570 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 378753000571 FAD binding pocket [chemical binding]; other site 378753000572 FAD binding motif [chemical binding]; other site 378753000573 phosphate binding motif [ion binding]; other site 378753000574 beta-alpha-beta structure motif; other site 378753000575 NAD(p) ribose binding residues [chemical binding]; other site 378753000576 NAD binding pocket [chemical binding]; other site 378753000577 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 378753000578 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 378753000579 catalytic loop [active] 378753000580 iron binding site [ion binding]; other site 378753000581 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 378753000582 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 378753000583 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 378753000584 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 378753000585 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 378753000586 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 378753000587 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 378753000588 CoenzymeA binding site [chemical binding]; other site 378753000589 subunit interaction site [polypeptide binding]; other site 378753000590 PHB binding site; other site 378753000591 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753000592 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 378753000593 acyl-activating enzyme (AAE) consensus motif; other site 378753000594 AMP binding site [chemical binding]; other site 378753000595 active site 378753000596 CoA binding site [chemical binding]; other site 378753000597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753000598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753000600 Coenzyme A binding pocket [chemical binding]; other site 378753000601 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 378753000602 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 378753000603 substrate binding site [chemical binding]; other site 378753000604 dimer interface [polypeptide binding]; other site 378753000605 NADP binding site [chemical binding]; other site 378753000606 catalytic residues [active] 378753000607 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 378753000608 active site 2 [active] 378753000609 active site 1 [active] 378753000610 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 378753000611 CoenzymeA binding site [chemical binding]; other site 378753000612 subunit interaction site [polypeptide binding]; other site 378753000613 PHB binding site; other site 378753000614 isocitrate lyase; Provisional; Region: PRK15063 378753000615 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 378753000616 tetramer interface [polypeptide binding]; other site 378753000617 active site 378753000618 Mg2+/Mn2+ binding site [ion binding]; other site 378753000619 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 378753000620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378753000621 sequence-specific DNA binding site [nucleotide binding]; other site 378753000622 salt bridge; other site 378753000623 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 378753000624 Domain of unknown function (DUF955); Region: DUF955; cl01076 378753000625 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 378753000626 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 378753000627 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 378753000628 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378753000629 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 378753000630 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753000631 substrate binding site [chemical binding]; other site 378753000632 oxyanion hole (OAH) forming residues; other site 378753000633 trimer interface [polypeptide binding]; other site 378753000634 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 378753000635 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378753000636 dimer interface [polypeptide binding]; other site 378753000637 active site 378753000638 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753000639 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000640 putative substrate translocation pore; other site 378753000641 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 378753000642 substrate binding site [chemical binding]; other site 378753000643 THF binding site; other site 378753000644 zinc-binding site [ion binding]; other site 378753000645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753000646 NAD(P) binding site [chemical binding]; other site 378753000647 active site 378753000648 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 378753000649 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 378753000650 putative acyltransferase; Provisional; Region: PRK05790 378753000651 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378753000652 dimer interface [polypeptide binding]; other site 378753000653 active site 378753000654 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 378753000655 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 378753000656 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 378753000657 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 378753000658 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 378753000659 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000661 putative substrate translocation pore; other site 378753000662 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 378753000663 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753000664 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 378753000665 Coenzyme A binding pocket [chemical binding]; other site 378753000666 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000667 biotin synthase; Validated; Region: PRK06256 378753000668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 378753000669 FeS/SAM binding site; other site 378753000670 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 378753000671 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 378753000672 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 378753000673 inhibitor-cofactor binding pocket; inhibition site 378753000674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753000675 catalytic residue [active] 378753000676 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 378753000677 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 378753000678 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753000679 catalytic residue [active] 378753000680 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 378753000681 CHAT domain; Region: CHAT; pfam12770 378753000682 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 378753000683 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 378753000684 N- and C-terminal domain interface [polypeptide binding]; other site 378753000685 active site 378753000686 catalytic site [active] 378753000687 metal binding site [ion binding]; metal-binding site 378753000688 carbohydrate binding site [chemical binding]; other site 378753000689 ATP binding site [chemical binding]; other site 378753000690 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 378753000691 Helix-turn-helix domain; Region: HTH_38; pfam13936 378753000692 Integrase core domain; Region: rve; pfam00665 378753000693 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753000694 Walker A/P-loop; other site 378753000695 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 378753000696 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 378753000697 Thioredoxin; Region: Thioredoxin_4; cl17273 378753000698 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 378753000699 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 378753000700 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 378753000701 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722 378753000702 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 378753000703 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 378753000704 amino acid carrier protein; Region: agcS; TIGR00835 378753000705 Uncharacterized membrane protein [Function unknown]; Region: COG3949 378753000706 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 378753000707 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 378753000708 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 378753000709 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 378753000710 proximal heme binding site [chemical binding]; other site 378753000711 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 378753000712 putative dimer interface [polypeptide binding]; other site 378753000713 distal heme binding site [chemical binding]; other site 378753000714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000715 WHG domain; Region: WHG; pfam13305 378753000716 Helix-turn-helix domain; Region: HTH_28; pfam13518 378753000717 Winged helix-turn helix; Region: HTH_29; pfam13551 378753000718 Integrase core domain; Region: rve; pfam00665 378753000719 Integrase core domain; Region: rve_3; pfam13683 378753000720 Protein of unknown function (DUF664); Region: DUF664; pfam04978 378753000721 DinB superfamily; Region: DinB_2; pfam12867 378753000722 6-hydroxyhexanoate dehydrogenase; Region: 6_hydroxyhexanoate_dh_like; cd08240 378753000723 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378753000724 putative NAD(P) binding site [chemical binding]; other site 378753000725 catalytic Zn binding site [ion binding]; other site 378753000726 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 378753000727 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 378753000728 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 378753000729 putative active site [active] 378753000730 catalytic site [active] 378753000731 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 378753000732 putative active site [active] 378753000733 catalytic site [active] 378753000734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753000735 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 378753000736 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 378753000737 dimerization interface [polypeptide binding]; other site 378753000738 ATP binding site [chemical binding]; other site 378753000739 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 378753000740 dimerization interface [polypeptide binding]; other site 378753000741 ATP binding site [chemical binding]; other site 378753000742 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 378753000743 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 378753000744 putative active site [active] 378753000745 catalytic triad [active] 378753000746 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 378753000747 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 378753000748 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 378753000749 Citrate transporter; Region: CitMHS; pfam03600 378753000750 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 378753000751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753000752 ATP binding site [chemical binding]; other site 378753000753 Mg2+ binding site [ion binding]; other site 378753000754 G-X-G motif; other site 378753000755 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 378753000756 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753000757 active site 378753000758 phosphorylation site [posttranslational modification] 378753000759 intermolecular recognition site; other site 378753000760 dimerization interface [polypeptide binding]; other site 378753000761 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 378753000762 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 378753000763 iron-sulfur cluster [ion binding]; other site 378753000764 [2Fe-2S] cluster binding site [ion binding]; other site 378753000765 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753000766 MarR family; Region: MarR; pfam01047 378753000767 aspartate kinase; Reviewed; Region: PRK06635 378753000768 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 378753000769 putative nucleotide binding site [chemical binding]; other site 378753000770 putative catalytic residues [active] 378753000771 putative Mg ion binding site [ion binding]; other site 378753000772 putative aspartate binding site [chemical binding]; other site 378753000773 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 378753000774 putative allosteric regulatory site; other site 378753000775 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 378753000776 putative allosteric regulatory residue; other site 378753000777 recombination protein RecR; Reviewed; Region: recR; PRK00076 378753000778 RecR protein; Region: RecR; pfam02132 378753000779 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 378753000780 putative active site [active] 378753000781 putative metal-binding site [ion binding]; other site 378753000782 tetramer interface [polypeptide binding]; other site 378753000783 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 378753000784 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753000785 Walker A motif; other site 378753000786 ATP binding site [chemical binding]; other site 378753000787 Walker B motif; other site 378753000788 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 378753000789 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 378753000790 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 378753000791 generic binding surface I; other site 378753000792 generic binding surface II; other site 378753000793 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 378753000794 putative active site [active] 378753000795 putative catalytic site [active] 378753000796 putative Mg binding site IVb [ion binding]; other site 378753000797 putative phosphate binding site [ion binding]; other site 378753000798 putative DNA binding site [nucleotide binding]; other site 378753000799 putative Mg binding site IVa [ion binding]; other site 378753000800 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753000801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000802 Cytochrome c; Region: Cytochrom_C; cl11414 378753000803 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 378753000804 dimer interface [polypeptide binding]; other site 378753000805 substrate binding site [chemical binding]; other site 378753000806 ATP binding site [chemical binding]; other site 378753000807 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 378753000808 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378753000809 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 378753000810 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 378753000811 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 378753000812 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 378753000813 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 378753000814 Transcriptional regulator [Transcription]; Region: IclR; COG1414 378753000815 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 378753000816 non-specific DNA interactions [nucleotide binding]; other site 378753000817 DNA binding site [nucleotide binding] 378753000818 sequence specific DNA binding site [nucleotide binding]; other site 378753000819 putative cAMP binding site [chemical binding]; other site 378753000820 Bacterial transcriptional regulator; Region: IclR; pfam01614 378753000821 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 378753000822 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 378753000823 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 378753000824 active site 378753000825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753000826 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753000827 putative substrate translocation pore; other site 378753000828 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 378753000829 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 378753000830 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 378753000831 active site 378753000832 metal binding site [ion binding]; metal-binding site 378753000833 nudix motif; other site 378753000834 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 378753000835 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 378753000836 active site 378753000837 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 378753000838 LGFP repeat; Region: LGFP; pfam08310 378753000839 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 378753000840 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 378753000841 putative DNA binding site [nucleotide binding]; other site 378753000842 catalytic residue [active] 378753000843 putative H2TH interface [polypeptide binding]; other site 378753000844 putative catalytic residues [active] 378753000845 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 378753000846 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 378753000847 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378753000848 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378753000849 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753000850 ATP binding site [chemical binding]; other site 378753000851 putative Mg++ binding site [ion binding]; other site 378753000852 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753000853 nucleotide binding region [chemical binding]; other site 378753000854 ATP-binding site [chemical binding]; other site 378753000855 DEAD/H associated; Region: DEAD_assoc; pfam08494 378753000856 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 378753000857 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 378753000858 FAD binding domain; Region: FAD_binding_4; pfam01565 378753000859 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 378753000860 Cysteine-rich domain; Region: CCG; pfam02754 378753000861 sn-glycerol-3-phosphate dehydrogenase subunit C; Provisional; Region: glpC; PRK11168 378753000862 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 378753000863 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 378753000864 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 378753000865 Fatty acid desaturase; Region: FA_desaturase; pfam00487 378753000866 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 378753000867 putative di-iron ligands [ion binding]; other site 378753000868 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 378753000869 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 378753000870 FAD binding pocket [chemical binding]; other site 378753000871 FAD binding motif [chemical binding]; other site 378753000872 phosphate binding motif [ion binding]; other site 378753000873 beta-alpha-beta structure motif; other site 378753000874 NAD binding pocket [chemical binding]; other site 378753000875 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 378753000876 catalytic loop [active] 378753000877 iron binding site [ion binding]; other site 378753000878 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 378753000879 nucleoside/Zn binding site; other site 378753000880 dimer interface [polypeptide binding]; other site 378753000881 catalytic motif [active] 378753000882 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 378753000883 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378753000884 FtsX-like permease family; Region: FtsX; pfam02687 378753000885 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378753000886 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 378753000887 Walker A/P-loop; other site 378753000888 ATP binding site [chemical binding]; other site 378753000889 Q-loop/lid; other site 378753000890 ABC transporter signature motif; other site 378753000891 Walker B; other site 378753000892 D-loop; other site 378753000893 H-loop/switch region; other site 378753000894 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753000895 active site 378753000896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 378753000897 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378753000898 DNA binding site [nucleotide binding] 378753000899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378753000900 catalytic core [active] 378753000901 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 378753000902 Excalibur calcium-binding domain; Region: Excalibur; smart00894 378753000903 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 378753000904 active site 378753000905 substrate-binding site [chemical binding]; other site 378753000906 metal-binding site [ion binding] 378753000907 GTP binding site [chemical binding]; other site 378753000908 Predicted transcriptional regulator [Transcription]; Region: COG1959 378753000909 Transcriptional regulator; Region: Rrf2; cl17282 378753000910 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 378753000911 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 378753000912 heme-binding site [chemical binding]; other site 378753000913 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 378753000914 FAD binding pocket [chemical binding]; other site 378753000915 FAD binding motif [chemical binding]; other site 378753000916 phosphate binding motif [ion binding]; other site 378753000917 beta-alpha-beta structure motif; other site 378753000918 NAD binding pocket [chemical binding]; other site 378753000919 Heme binding pocket [chemical binding]; other site 378753000920 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 378753000921 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 378753000922 active site 378753000923 substrate binding site [chemical binding]; other site 378753000924 metal binding site [ion binding]; metal-binding site 378753000925 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 378753000926 Phosphomannose isomerase type I; Region: PMI_typeI; pfam01238 378753000927 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 378753000928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753000929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753000930 NADH(P)-binding; Region: NAD_binding_10; pfam13460 378753000931 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 378753000932 NAD(P) binding site [chemical binding]; other site 378753000933 putative active site [active] 378753000934 Acylphosphatase; Region: Acylphosphatase; cl00551 378753000935 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 378753000936 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 378753000937 active site 378753000938 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 378753000939 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 378753000940 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378753000941 active site 378753000942 catalytic site [active] 378753000943 adenylosuccinate lyase; Provisional; Region: PRK09285 378753000944 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 378753000945 tetramer interface [polypeptide binding]; other site 378753000946 Proteins of 100 residues with WXG; Region: WXG100; cl02005 378753000947 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 378753000948 nucleophilic elbow; other site 378753000949 catalytic triad; other site 378753000950 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 378753000951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753000952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753000953 homodimer interface [polypeptide binding]; other site 378753000954 catalytic residue [active] 378753000955 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 378753000956 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 378753000957 TPP-binding site [chemical binding]; other site 378753000958 tetramer interface [polypeptide binding]; other site 378753000959 heterodimer interface [polypeptide binding]; other site 378753000960 phosphorylation loop region [posttranslational modification] 378753000961 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 378753000962 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 378753000963 alpha subunit interface [polypeptide binding]; other site 378753000964 TPP binding site [chemical binding]; other site 378753000965 heterodimer interface [polypeptide binding]; other site 378753000966 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378753000967 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378753000968 E3 interaction surface; other site 378753000969 lipoyl attachment site [posttranslational modification]; other site 378753000970 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 378753000971 e3 binding domain; Region: E3_binding; pfam02817 378753000972 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 378753000973 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 378753000974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378753000975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753000976 ATP binding site [chemical binding]; other site 378753000977 Mg2+ binding site [ion binding]; other site 378753000978 G-X-G motif; other site 378753000979 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753000980 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753000981 DNA binding residues [nucleotide binding] 378753000982 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK05605 378753000983 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753000984 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753000985 acyl-activating enzyme (AAE) consensus motif; other site 378753000986 AMP binding site [chemical binding]; other site 378753000987 active site 378753000988 CoA binding site [chemical binding]; other site 378753000989 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 378753000990 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 378753000991 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 378753000992 dimerization interface [polypeptide binding]; other site 378753000993 substrate binding pocket [chemical binding]; other site 378753000994 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378753000995 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 378753000996 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378753000997 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 378753000998 putative dimer interface [polypeptide binding]; other site 378753000999 N-terminal domain interface [polypeptide binding]; other site 378753001000 putative substrate binding pocket (H-site) [chemical binding]; other site 378753001001 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 378753001002 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 378753001003 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 378753001004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753001005 motif II; other site 378753001006 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 378753001007 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 378753001008 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 378753001009 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 378753001010 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 378753001011 IHF dimer interface [polypeptide binding]; other site 378753001012 IHF - DNA interface [nucleotide binding]; other site 378753001013 CopC domain; Region: CopC; pfam04234 378753001014 Protein of unknown function (DUF461); Region: DUF461; pfam04314 378753001015 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 378753001016 Copper resistance protein D; Region: CopD; pfam05425 378753001017 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 378753001018 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378753001019 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 378753001020 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 378753001021 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 378753001022 Walker A/P-loop; other site 378753001023 ATP binding site [chemical binding]; other site 378753001024 Q-loop/lid; other site 378753001025 ABC transporter signature motif; other site 378753001026 Walker B; other site 378753001027 D-loop; other site 378753001028 H-loop/switch region; other site 378753001029 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 378753001030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753001031 dimer interface [polypeptide binding]; other site 378753001032 conserved gate region; other site 378753001033 ABC-ATPase subunit interface; other site 378753001034 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 378753001035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753001036 dimer interface [polypeptide binding]; other site 378753001037 putative PBP binding loops; other site 378753001038 ABC-ATPase subunit interface; other site 378753001039 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 378753001040 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 378753001041 Predicted permeases [General function prediction only]; Region: COG0679 378753001042 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 378753001043 tetramerization interface [polypeptide binding]; other site 378753001044 active site 378753001045 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 378753001046 trimer interface [polypeptide binding]; other site 378753001047 active site 378753001048 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 378753001049 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 378753001050 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 378753001051 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 378753001052 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 378753001053 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 378753001054 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 378753001055 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 378753001056 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 378753001057 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 378753001058 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 378753001059 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 378753001060 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 378753001061 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 378753001062 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 378753001063 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 378753001064 Walker A/P-loop; other site 378753001065 ATP binding site [chemical binding]; other site 378753001066 Q-loop/lid; other site 378753001067 ABC transporter signature motif; other site 378753001068 Walker B; other site 378753001069 D-loop; other site 378753001070 H-loop/switch region; other site 378753001071 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 378753001072 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 378753001073 Walker A/P-loop; other site 378753001074 ATP binding site [chemical binding]; other site 378753001075 Q-loop/lid; other site 378753001076 ABC transporter signature motif; other site 378753001077 Walker B; other site 378753001078 D-loop; other site 378753001079 H-loop/switch region; other site 378753001080 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 378753001081 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 378753001082 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 378753001083 homodimer interface [polypeptide binding]; other site 378753001084 substrate-cofactor binding pocket; other site 378753001085 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753001086 catalytic residue [active] 378753001087 hypothetical protein; Provisional; Region: PRK06547 378753001088 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 378753001089 Low molecular weight phosphatase family; Region: LMWPc; cd00115 378753001090 active site 378753001091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753001092 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 378753001093 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 378753001094 BCCT family transporter; Region: BCCT; pfam02028 378753001095 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 378753001096 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 378753001097 nucleotide binding site [chemical binding]; other site 378753001098 GrpE; Region: GrpE; pfam01025 378753001099 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 378753001100 dimer interface [polypeptide binding]; other site 378753001101 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 378753001102 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 378753001103 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 378753001104 HSP70 interaction site [polypeptide binding]; other site 378753001105 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 378753001106 substrate binding site [polypeptide binding]; other site 378753001107 dimer interface [polypeptide binding]; other site 378753001108 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 378753001109 DNA binding residues [nucleotide binding] 378753001110 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 378753001111 putative dimer interface [polypeptide binding]; other site 378753001112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753001113 S-adenosylmethionine binding site [chemical binding]; other site 378753001114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753001115 putative substrate translocation pore; other site 378753001116 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 378753001117 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 378753001118 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 378753001119 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 378753001120 active site 378753001121 phosphate binding residues; other site 378753001122 catalytic residues [active] 378753001123 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 378753001124 amino acid carrier protein; Region: agcS; TIGR00835 378753001125 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 378753001126 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 378753001127 potential catalytic triad [active] 378753001128 conserved cys residue [active] 378753001129 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378753001130 classical (c) SDRs; Region: SDR_c; cd05233 378753001131 NAD(P) binding site [chemical binding]; other site 378753001132 active site 378753001133 short chain dehydrogenase; Provisional; Region: PRK06172 378753001134 classical (c) SDRs; Region: SDR_c; cd05233 378753001135 NAD(P) binding site [chemical binding]; other site 378753001136 active site 378753001137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 378753001138 DEAD-like helicases superfamily; Region: DEXDc; smart00487 378753001139 ATP binding site [chemical binding]; other site 378753001140 putative Mg++ binding site [ion binding]; other site 378753001141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753001142 nucleotide binding region [chemical binding]; other site 378753001143 ATP-binding site [chemical binding]; other site 378753001144 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 378753001145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753001146 motif II; other site 378753001147 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 378753001148 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 378753001149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753001150 motif II; other site 378753001151 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753001152 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 378753001153 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 378753001154 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 378753001155 Clp amino terminal domain; Region: Clp_N; pfam02861 378753001156 Clp amino terminal domain; Region: Clp_N; pfam02861 378753001157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753001158 Walker A motif; other site 378753001159 ATP binding site [chemical binding]; other site 378753001160 Walker B motif; other site 378753001161 arginine finger; other site 378753001162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753001163 Walker A motif; other site 378753001164 ATP binding site [chemical binding]; other site 378753001165 Walker B motif; other site 378753001166 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378753001167 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 378753001168 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 378753001169 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 378753001170 dimerization interface [polypeptide binding]; other site 378753001171 putative ATP binding site [chemical binding]; other site 378753001172 amidophosphoribosyltransferase; Provisional; Region: PRK07847 378753001173 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 378753001174 active site 378753001175 tetramer interface [polypeptide binding]; other site 378753001176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753001177 active site 378753001178 L-asparaginase II; Region: Asparaginase_II; pfam06089 378753001179 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 378753001180 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 378753001181 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 378753001182 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 378753001183 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 378753001184 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 378753001185 ATP binding site [chemical binding]; other site 378753001186 active site 378753001187 substrate binding site [chemical binding]; other site 378753001188 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 378753001189 DNA binding site [nucleotide binding] 378753001190 active site 378753001191 Histidine kinase; Region: HisKA_3; pfam07730 378753001192 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 378753001193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753001194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753001195 active site 378753001196 phosphorylation site [posttranslational modification] 378753001197 intermolecular recognition site; other site 378753001198 dimerization interface [polypeptide binding]; other site 378753001199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753001200 DNA binding residues [nucleotide binding] 378753001201 dimerization interface [polypeptide binding]; other site 378753001202 Transcriptional regulators [Transcription]; Region: GntR; COG1802 378753001203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753001204 DNA-binding site [nucleotide binding]; DNA binding site 378753001205 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 378753001206 L-lactate permease; Region: Lactate_perm; cl00701 378753001207 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 378753001208 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 378753001209 Cysteine-rich domain; Region: CCG; pfam02754 378753001210 Cysteine-rich domain; Region: CCG; pfam02754 378753001211 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 378753001212 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 378753001213 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 378753001214 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 378753001215 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 378753001216 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 378753001217 ATP binding site [chemical binding]; other site 378753001218 substrate interface [chemical binding]; other site 378753001219 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 378753001220 active site residue [active] 378753001221 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 378753001222 ThiS interaction site; other site 378753001223 putative active site [active] 378753001224 tetramer interface [polypeptide binding]; other site 378753001225 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 378753001226 thiS-thiF/thiG interaction site; other site 378753001227 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 378753001228 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 378753001229 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 378753001230 thiamine phosphate binding site [chemical binding]; other site 378753001231 active site 378753001232 pyrophosphate binding site [ion binding]; other site 378753001233 Protein of unknown function, DUF393; Region: DUF393; pfam04134 378753001234 Protein of unknown function, DUF393; Region: DUF393; cl01136 378753001235 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 378753001236 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 378753001237 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753001238 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 378753001239 FAD binding domain; Region: FAD_binding_4; pfam01565 378753001240 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 378753001241 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 378753001242 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 378753001243 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 378753001244 putative active site [active] 378753001245 putative metal binding site [ion binding]; other site 378753001246 Transglycosylase; Region: Transgly; pfam00912 378753001247 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 378753001248 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 378753001249 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 378753001250 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 378753001251 homotrimer interaction site [polypeptide binding]; other site 378753001252 putative active site [active] 378753001253 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 378753001254 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378753001255 ligand binding site [chemical binding]; other site 378753001256 flexible hinge region; other site 378753001257 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 378753001258 putative switch regulator; other site 378753001259 non-specific DNA interactions [nucleotide binding]; other site 378753001260 DNA binding site [nucleotide binding] 378753001261 sequence specific DNA binding site [nucleotide binding]; other site 378753001262 putative cAMP binding site [chemical binding]; other site 378753001263 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 378753001264 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 378753001265 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 378753001266 Dehydroquinase class II; Region: DHquinase_II; pfam01220 378753001267 trimer interface [polypeptide binding]; other site 378753001268 active site 378753001269 dimer interface [polypeptide binding]; other site 378753001270 acetyl-CoA synthetase; Provisional; Region: PRK00174 378753001271 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 378753001272 active site 378753001273 CoA binding site [chemical binding]; other site 378753001274 acyl-activating enzyme (AAE) consensus motif; other site 378753001275 AMP binding site [chemical binding]; other site 378753001276 acetate binding site [chemical binding]; other site 378753001277 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 378753001278 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378753001279 minor groove reading motif; other site 378753001280 helix-hairpin-helix signature motif; other site 378753001281 substrate binding pocket [chemical binding]; other site 378753001282 active site 378753001283 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 378753001284 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 378753001285 putative active site [active] 378753001286 putative CoA binding site [chemical binding]; other site 378753001287 nudix motif; other site 378753001288 metal binding site [ion binding]; metal-binding site 378753001289 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 378753001290 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 378753001291 active site 378753001292 DNA binding site [nucleotide binding] 378753001293 catalytic site [active] 378753001294 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 378753001295 HD domain; Region: HD_4; pfam13328 378753001296 Peptidyl-tRNA hydrolase [Translation, ribosomal structure and biogenesis]; Region: pth2; cl17334 378753001297 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 378753001298 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 378753001299 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 378753001300 ATP binding site [chemical binding]; other site 378753001301 Walker A motif; other site 378753001302 hexamer interface [polypeptide binding]; other site 378753001303 Walker B motif; other site 378753001304 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 378753001305 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 378753001306 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 378753001307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753001308 ATP binding site [chemical binding]; other site 378753001309 putative Mg++ binding site [ion binding]; other site 378753001310 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 378753001311 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 378753001312 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 378753001313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753001314 S-adenosylmethionine binding site [chemical binding]; other site 378753001315 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 378753001316 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 378753001317 active site 378753001318 interdomain interaction site; other site 378753001319 putative metal-binding site [ion binding]; other site 378753001320 nucleotide binding site [chemical binding]; other site 378753001321 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 378753001322 domain I; other site 378753001323 phosphate binding site [ion binding]; other site 378753001324 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 378753001325 domain II; other site 378753001326 domain III; other site 378753001327 nucleotide binding site [chemical binding]; other site 378753001328 DNA binding groove [nucleotide binding] 378753001329 catalytic site [active] 378753001330 domain IV; other site 378753001331 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 378753001332 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 378753001333 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 378753001334 exopolyphosphatase; Region: exo_poly_only; TIGR03706 378753001335 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 378753001336 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 378753001337 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 378753001338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753001339 Coenzyme A binding pocket [chemical binding]; other site 378753001340 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 378753001341 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 378753001342 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 378753001343 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 378753001344 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 378753001345 TrkA-N domain; Region: TrkA_N; pfam02254 378753001346 TrkA-C domain; Region: TrkA_C; pfam02080 378753001347 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 378753001348 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 378753001349 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 378753001350 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 378753001351 active site 378753001352 Zn binding site [ion binding]; other site 378753001353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753001354 putative DNA binding site [nucleotide binding]; other site 378753001355 dimerization interface [polypeptide binding]; other site 378753001356 putative Zn2+ binding site [ion binding]; other site 378753001357 glutamate dehydrogenase; Provisional; Region: PRK09414 378753001358 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 378753001359 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 378753001360 NAD(P) binding site [chemical binding]; other site 378753001361 Transcriptional regulators [Transcription]; Region: FadR; COG2186 378753001362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753001363 DNA-binding site [nucleotide binding]; DNA binding site 378753001364 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 378753001365 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 378753001366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378753001367 catalytic core [active] 378753001368 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 378753001369 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 378753001370 catalytic residues [active] 378753001371 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 378753001372 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 378753001373 ResB-like family; Region: ResB; pfam05140 378753001374 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 378753001375 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 378753001376 Protein of unknown function (DUF4229); Region: DUF4229; pfam14012 378753001377 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 378753001378 UbiA prenyltransferase family; Region: UbiA; pfam01040 378753001379 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 378753001380 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753001381 acyl-activating enzyme (AAE) consensus motif; other site 378753001382 AMP binding site [chemical binding]; other site 378753001383 active site 378753001384 CoA binding site [chemical binding]; other site 378753001385 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 378753001386 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753001387 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 378753001388 substrate binding site [chemical binding]; other site 378753001389 oxyanion hole (OAH) forming residues; other site 378753001390 trimer interface [polypeptide binding]; other site 378753001391 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 378753001392 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 378753001393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753001394 putative Mg++ binding site [ion binding]; other site 378753001395 nucleotide binding region [chemical binding]; other site 378753001396 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 378753001397 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 378753001398 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 378753001399 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 378753001400 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 378753001401 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 378753001402 NAD binding site [chemical binding]; other site 378753001403 dimer interface [polypeptide binding]; other site 378753001404 substrate binding site [chemical binding]; other site 378753001405 tetramer (dimer of dimers) interface [polypeptide binding]; other site 378753001406 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 378753001407 Na binding site [ion binding]; other site 378753001408 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 378753001409 active site 378753001410 HIGH motif; other site 378753001411 nucleotide binding site [chemical binding]; other site 378753001412 active site 378753001413 KMSKS motif; other site 378753001414 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 378753001415 acyl-coenzyme A oxidase; Region: PLN02526 378753001416 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753001417 active site 378753001418 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 378753001419 CoA-transferase family III; Region: CoA_transf_3; pfam02515 378753001420 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 378753001421 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 378753001422 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 378753001423 dimerization interface [polypeptide binding]; other site 378753001424 substrate binding pocket [chemical binding]; other site 378753001425 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 378753001426 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 378753001427 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378753001428 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 378753001429 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753001430 substrate binding site [chemical binding]; other site 378753001431 oxyanion hole (OAH) forming residues; other site 378753001432 trimer interface [polypeptide binding]; other site 378753001433 TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123 378753001434 DctM-like transporters; Region: DctM; pfam06808 378753001435 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 378753001436 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 378753001437 cytidine deaminase; Validated; Region: PRK08298 378753001438 active site 378753001439 Zn binding site [ion binding]; other site 378753001440 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 378753001441 catalytic residue [active] 378753001442 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 378753001443 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 378753001444 PIN domain; Region: PIN_3; pfam13470 378753001445 Helix-turn-helix domain; Region: HTH_17; cl17695 378753001446 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 378753001447 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 378753001448 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 378753001449 HsdM N-terminal domain; Region: HsdM_N; pfam12161 378753001450 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 378753001451 Methyltransferase domain; Region: Methyltransf_26; pfam13659 378753001452 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 378753001453 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 378753001454 Protein of unknown function (Hypoth_ymh); Region: Hypoth_Ymh; pfam09509 378753001455 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 378753001456 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 378753001457 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753001458 ATP binding site [chemical binding]; other site 378753001459 putative Mg++ binding site [ion binding]; other site 378753001460 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 378753001461 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 378753001462 metal binding site 2 [ion binding]; metal-binding site 378753001463 putative DNA binding helix; other site 378753001464 metal binding site 1 [ion binding]; metal-binding site 378753001465 dimer interface [polypeptide binding]; other site 378753001466 structural Zn2+ binding site [ion binding]; other site 378753001467 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 378753001468 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 378753001469 tetramer interface [polypeptide binding]; other site 378753001470 heme binding pocket [chemical binding]; other site 378753001471 NADPH binding site [chemical binding]; other site 378753001472 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 378753001473 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 378753001474 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 378753001475 O-succinylbenzoate synthase; Provisional; Region: PRK02901 378753001476 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 378753001477 active site 378753001478 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 378753001479 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 378753001480 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 378753001481 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 378753001482 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 378753001483 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 378753001484 Active Sites [active] 378753001485 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 378753001486 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 378753001487 Active Sites [active] 378753001488 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 378753001489 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 378753001490 CysD dimerization site [polypeptide binding]; other site 378753001491 G1 box; other site 378753001492 putative GEF interaction site [polypeptide binding]; other site 378753001493 GTP/Mg2+ binding site [chemical binding]; other site 378753001494 Switch I region; other site 378753001495 G2 box; other site 378753001496 G3 box; other site 378753001497 Switch II region; other site 378753001498 G4 box; other site 378753001499 G5 box; other site 378753001500 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 378753001501 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 378753001502 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 378753001503 dimer interface [polypeptide binding]; other site 378753001504 tetramer interface [polypeptide binding]; other site 378753001505 PYR/PP interface [polypeptide binding]; other site 378753001506 TPP binding site [chemical binding]; other site 378753001507 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 378753001508 TPP-binding site; other site 378753001509 short chain dehydrogenase; Provisional; Region: PRK08219 378753001510 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753001511 NAD(P) binding site [chemical binding]; other site 378753001512 active site 378753001513 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 378753001514 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 378753001515 substrate binding pocket [chemical binding]; other site 378753001516 membrane-bound complex binding site; other site 378753001517 hinge residues; other site 378753001518 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 378753001519 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 378753001520 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753001521 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 378753001522 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378753001523 substrate binding pocket [chemical binding]; other site 378753001524 chain length determination region; other site 378753001525 substrate-Mg2+ binding site; other site 378753001526 catalytic residues [active] 378753001527 aspartate-rich region 1; other site 378753001528 active site lid residues [active] 378753001529 aspartate-rich region 2; other site 378753001530 uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334 378753001531 Na2 binding site [ion binding]; other site 378753001532 putative substrate binding site 1 [chemical binding]; other site 378753001533 Na binding site 1 [ion binding]; other site 378753001534 putative substrate binding site 2 [chemical binding]; other site 378753001535 Predicted permeases [General function prediction only]; Region: RarD; COG2962 378753001536 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 378753001537 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 378753001538 tetramer interface [polypeptide binding]; other site 378753001539 heme binding pocket [chemical binding]; other site 378753001540 NADPH binding site [chemical binding]; other site 378753001541 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 378753001542 metal binding site 2 [ion binding]; metal-binding site 378753001543 putative DNA binding helix; other site 378753001544 metal binding site 1 [ion binding]; metal-binding site 378753001545 dimer interface [polypeptide binding]; other site 378753001546 structural Zn2+ binding site [ion binding]; other site 378753001547 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 378753001548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378753001549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 378753001550 DNA binding residues [nucleotide binding] 378753001551 Putative zinc-finger; Region: zf-HC2; pfam13490 378753001552 heat shock protein HtpX; Provisional; Region: PRK03072 378753001553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 378753001554 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 378753001555 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 378753001556 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378753001557 catalytic residues [active] 378753001558 CCC1-related family of proteins; Region: CCC1_like; cl00278 378753001559 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 378753001560 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 378753001561 helix-hairpin-helix signature motif; other site 378753001562 active site 378753001563 Predicted membrane protein [Function unknown]; Region: COG3463 378753001564 helicase 45; Provisional; Region: PTZ00424 378753001565 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 378753001566 ATP binding site [chemical binding]; other site 378753001567 Mg++ binding site [ion binding]; other site 378753001568 motif III; other site 378753001569 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753001570 nucleotide binding region [chemical binding]; other site 378753001571 ATP-binding site [chemical binding]; other site 378753001572 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 378753001573 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 378753001574 active site 378753001575 catalytic site [active] 378753001576 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 378753001577 active site 378753001578 catalytic site [active] 378753001579 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 378753001580 FAD binding domain; Region: FAD_binding_4; pfam01565 378753001581 FAD binding domain; Region: FAD_binding_4; pfam01565 378753001582 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 378753001583 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 378753001584 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 378753001585 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 378753001586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753001587 Coenzyme A binding pocket [chemical binding]; other site 378753001588 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 378753001589 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 378753001590 folate binding site [chemical binding]; other site 378753001591 NADP+ binding site [chemical binding]; other site 378753001592 thymidylate synthase; Reviewed; Region: thyA; PRK01827 378753001593 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 378753001594 dimerization interface [polypeptide binding]; other site 378753001595 active site 378753001596 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 378753001597 active site 378753001598 Ap6A binding site [chemical binding]; other site 378753001599 nudix motif; other site 378753001600 metal binding site [ion binding]; metal-binding site 378753001601 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378753001602 catalytic core [active] 378753001603 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 378753001604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753001605 Coenzyme A binding pocket [chemical binding]; other site 378753001606 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753001607 Coenzyme A binding pocket [chemical binding]; other site 378753001608 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378753001609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 378753001610 DNA binding site [nucleotide binding] 378753001611 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 378753001612 heme-binding site [chemical binding]; other site 378753001613 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 378753001614 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 378753001615 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 378753001616 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 378753001617 phosphofructokinase; Region: PFK_mixed; TIGR02483 378753001618 active site 378753001619 ADP/pyrophosphate binding site [chemical binding]; other site 378753001620 dimerization interface [polypeptide binding]; other site 378753001621 allosteric effector site; other site 378753001622 fructose-1,6-bisphosphate binding site; other site 378753001623 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 378753001624 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 378753001625 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 378753001626 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 378753001627 aspartate aminotransferase; Provisional; Region: PRK05764 378753001628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753001629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753001630 homodimer interface [polypeptide binding]; other site 378753001631 catalytic residue [active] 378753001632 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 378753001633 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 378753001634 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 378753001635 putative homodimer interface [polypeptide binding]; other site 378753001636 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 378753001637 heterodimer interface [polypeptide binding]; other site 378753001638 homodimer interface [polypeptide binding]; other site 378753001639 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 378753001640 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 378753001641 23S rRNA interface [nucleotide binding]; other site 378753001642 L7/L12 interface [polypeptide binding]; other site 378753001643 putative thiostrepton binding site; other site 378753001644 L25 interface [polypeptide binding]; other site 378753001645 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 378753001646 mRNA/rRNA interface [nucleotide binding]; other site 378753001647 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 378753001648 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 378753001649 dimer interface [polypeptide binding]; other site 378753001650 putative functional site; other site 378753001651 putative MPT binding site; other site 378753001652 Ubiquitin-like proteins; Region: UBQ; cl00155 378753001653 charged pocket; other site 378753001654 hydrophobic patch; other site 378753001655 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 378753001656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 378753001657 FeS/SAM binding site; other site 378753001658 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 378753001659 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 378753001660 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 378753001661 dimer interface [polypeptide binding]; other site 378753001662 putative functional site; other site 378753001663 putative MPT binding site; other site 378753001664 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 378753001665 trimer interface [polypeptide binding]; other site 378753001666 dimer interface [polypeptide binding]; other site 378753001667 putative active site [active] 378753001668 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 378753001669 MPT binding site; other site 378753001670 trimer interface [polypeptide binding]; other site 378753001671 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 378753001672 MoaE homodimer interface [polypeptide binding]; other site 378753001673 MoaD interaction [polypeptide binding]; other site 378753001674 active site residues [active] 378753001675 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 378753001676 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 378753001677 23S rRNA interface [nucleotide binding]; other site 378753001678 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 378753001679 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 378753001680 core dimer interface [polypeptide binding]; other site 378753001681 peripheral dimer interface [polypeptide binding]; other site 378753001682 L10 interface [polypeptide binding]; other site 378753001683 L11 interface [polypeptide binding]; other site 378753001684 putative EF-Tu interaction site [polypeptide binding]; other site 378753001685 putative EF-G interaction site [polypeptide binding]; other site 378753001686 glycine dehydrogenase; Provisional; Region: PRK05367 378753001687 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753001688 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753001689 catalytic residue [active] 378753001690 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 378753001691 tetramer interface [polypeptide binding]; other site 378753001692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753001693 catalytic residue [active] 378753001694 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 378753001695 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 378753001696 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 378753001697 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 378753001698 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 378753001699 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 378753001700 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 378753001701 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 378753001702 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 378753001703 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 378753001704 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 378753001705 RPB10 interaction site [polypeptide binding]; other site 378753001706 RPB1 interaction site [polypeptide binding]; other site 378753001707 RPB11 interaction site [polypeptide binding]; other site 378753001708 RPB3 interaction site [polypeptide binding]; other site 378753001709 RPB12 interaction site [polypeptide binding]; other site 378753001710 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 378753001711 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 378753001712 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 378753001713 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 378753001714 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 378753001715 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 378753001716 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 378753001717 G-loop; other site 378753001718 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 378753001719 DNA binding site [nucleotide binding] 378753001720 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 378753001721 Transcriptional regulator [Transcription]; Region: IclR; COG1414 378753001722 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 378753001723 Bacterial transcriptional regulator; Region: IclR; pfam01614 378753001724 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 378753001725 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 378753001726 active site 378753001727 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 378753001728 active site 378753001729 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 378753001730 tetramer interface [polypeptide binding]; other site 378753001731 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 378753001732 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 378753001733 Coenzyme A transferase; Region: CoA_trans; cl17247 378753001734 Coenzyme A transferase; Region: CoA_trans; cl17247 378753001735 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 378753001736 S17 interaction site [polypeptide binding]; other site 378753001737 S8 interaction site; other site 378753001738 16S rRNA interaction site [nucleotide binding]; other site 378753001739 streptomycin interaction site [chemical binding]; other site 378753001740 23S rRNA interaction site [nucleotide binding]; other site 378753001741 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 378753001742 30S ribosomal protein S7; Validated; Region: PRK05302 378753001743 elongation factor G; Reviewed; Region: PRK00007 378753001744 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 378753001745 G1 box; other site 378753001746 putative GEF interaction site [polypeptide binding]; other site 378753001747 GTP/Mg2+ binding site [chemical binding]; other site 378753001748 Switch I region; other site 378753001749 G2 box; other site 378753001750 G3 box; other site 378753001751 Switch II region; other site 378753001752 G4 box; other site 378753001753 G5 box; other site 378753001754 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 378753001755 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 378753001756 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 378753001757 elongation factor Tu; Reviewed; Region: PRK00049 378753001758 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 378753001759 G1 box; other site 378753001760 GEF interaction site [polypeptide binding]; other site 378753001761 GTP/Mg2+ binding site [chemical binding]; other site 378753001762 Switch I region; other site 378753001763 G2 box; other site 378753001764 G3 box; other site 378753001765 Switch II region; other site 378753001766 G4 box; other site 378753001767 G5 box; other site 378753001768 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 378753001769 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 378753001770 Antibiotic Binding Site [chemical binding]; other site 378753001771 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 378753001772 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 378753001773 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 378753001774 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 378753001775 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 378753001776 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 378753001777 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 378753001778 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 378753001779 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 378753001780 putative translocon binding site; other site 378753001781 protein-rRNA interface [nucleotide binding]; other site 378753001782 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 378753001783 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 378753001784 G-X-X-G motif; other site 378753001785 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 378753001786 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 378753001787 23S rRNA interface [nucleotide binding]; other site 378753001788 5S rRNA interface [nucleotide binding]; other site 378753001789 putative antibiotic binding site [chemical binding]; other site 378753001790 L25 interface [polypeptide binding]; other site 378753001791 L27 interface [polypeptide binding]; other site 378753001792 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 378753001793 putative translocon interaction site; other site 378753001794 23S rRNA interface [nucleotide binding]; other site 378753001795 signal recognition particle (SRP54) interaction site; other site 378753001796 L23 interface [polypeptide binding]; other site 378753001797 trigger factor interaction site; other site 378753001798 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 378753001799 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 378753001800 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 378753001801 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 378753001802 RNA binding site [nucleotide binding]; other site 378753001803 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 378753001804 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 378753001805 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 378753001806 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 378753001807 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 378753001808 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 378753001809 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 378753001810 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 378753001811 5S rRNA interface [nucleotide binding]; other site 378753001812 L27 interface [polypeptide binding]; other site 378753001813 23S rRNA interface [nucleotide binding]; other site 378753001814 L5 interface [polypeptide binding]; other site 378753001815 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 378753001816 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 378753001817 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 378753001818 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 378753001819 23S rRNA binding site [nucleotide binding]; other site 378753001820 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 378753001821 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 378753001822 SecY translocase; Region: SecY; pfam00344 378753001823 adenylate kinase; Reviewed; Region: adk; PRK00279 378753001824 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 378753001825 AMP-binding site [chemical binding]; other site 378753001826 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 378753001827 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 378753001828 active site 378753001829 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 378753001830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 378753001831 FeS/SAM binding site; other site 378753001832 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 378753001833 rRNA binding site [nucleotide binding]; other site 378753001834 predicted 30S ribosome binding site; other site 378753001835 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 378753001836 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 378753001837 30S ribosomal protein S13; Region: bact_S13; TIGR03631 378753001838 30S ribosomal protein S11; Validated; Region: PRK05309 378753001839 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 378753001840 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 378753001841 alphaNTD homodimer interface [polypeptide binding]; other site 378753001842 alphaNTD - beta interaction site [polypeptide binding]; other site 378753001843 alphaNTD - beta' interaction site [polypeptide binding]; other site 378753001844 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 378753001845 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 378753001846 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 378753001847 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 378753001848 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 378753001849 dimerization interface 3.5A [polypeptide binding]; other site 378753001850 active site 378753001851 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 378753001852 23S rRNA interface [nucleotide binding]; other site 378753001853 L3 interface [polypeptide binding]; other site 378753001854 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 378753001855 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 378753001856 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 378753001857 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 378753001858 active site 378753001859 substrate binding site [chemical binding]; other site 378753001860 metal binding site [ion binding]; metal-binding site 378753001861 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 378753001862 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 378753001863 pantothenate kinase; Provisional; Region: PRK05439 378753001864 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 378753001865 ATP-binding site [chemical binding]; other site 378753001866 CoA-binding site [chemical binding]; other site 378753001867 Mg2+-binding site [ion binding]; other site 378753001868 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 378753001869 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 378753001870 glutaminase active site [active] 378753001871 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 378753001872 dimer interface [polypeptide binding]; other site 378753001873 active site 378753001874 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 378753001875 dimer interface [polypeptide binding]; other site 378753001876 active site 378753001877 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 378753001878 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 378753001879 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 378753001880 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 378753001881 putative substrate binding site [chemical binding]; other site 378753001882 putative ATP binding site [chemical binding]; other site 378753001883 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 378753001884 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 378753001885 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 378753001886 active site 378753001887 catalytic site [active] 378753001888 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 378753001889 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 378753001890 active site 378753001891 catalytic site [active] 378753001892 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 378753001893 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 378753001894 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 378753001895 catalytic site [active] 378753001896 active site 378753001897 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 378753001898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 378753001899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378753001900 active site 378753001901 catalytic tetrad [active] 378753001902 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 378753001903 LysE type translocator; Region: LysE; cl00565 378753001904 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 378753001905 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 378753001906 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 378753001907 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 378753001908 putative ADP-binding pocket [chemical binding]; other site 378753001909 alanine racemase; Reviewed; Region: alr; PRK00053 378753001910 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 378753001911 active site 378753001912 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378753001913 dimer interface [polypeptide binding]; other site 378753001914 substrate binding site [chemical binding]; other site 378753001915 catalytic residues [active] 378753001916 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 378753001917 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 378753001918 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753001919 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 378753001920 Glycoprotease family; Region: Peptidase_M22; pfam00814 378753001921 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain; Region: NMT_C; pfam02799 378753001922 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 378753001923 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753001924 Coenzyme A binding pocket [chemical binding]; other site 378753001925 UGMP family protein; Validated; Region: PRK09604 378753001926 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 378753001927 carboxylate-amine ligase; Provisional; Region: PRK13517 378753001928 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 378753001929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753001930 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753001931 S-adenosylmethionine binding site [chemical binding]; other site 378753001932 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 378753001933 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 378753001934 intersubunit interface [polypeptide binding]; other site 378753001935 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 378753001936 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 378753001937 ABC-ATPase subunit interface; other site 378753001938 dimer interface [polypeptide binding]; other site 378753001939 putative PBP binding regions; other site 378753001940 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 378753001941 ABC-ATPase subunit interface; other site 378753001942 dimer interface [polypeptide binding]; other site 378753001943 putative PBP binding regions; other site 378753001944 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 378753001945 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 378753001946 Walker A/P-loop; other site 378753001947 ATP binding site [chemical binding]; other site 378753001948 Q-loop/lid; other site 378753001949 ABC transporter signature motif; other site 378753001950 Walker B; other site 378753001951 D-loop; other site 378753001952 H-loop/switch region; other site 378753001953 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 378753001954 oligomerisation interface [polypeptide binding]; other site 378753001955 mobile loop; other site 378753001956 roof hairpin; other site 378753001957 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 378753001958 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 378753001959 ring oligomerisation interface [polypeptide binding]; other site 378753001960 ATP/Mg binding site [chemical binding]; other site 378753001961 stacking interactions; other site 378753001962 hinge regions; other site 378753001963 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 378753001964 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 378753001965 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 378753001966 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 378753001967 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 378753001968 active site 378753001969 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 378753001970 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 378753001971 active site 378753001972 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 378753001973 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 378753001974 GMP synthase; Reviewed; Region: guaA; PRK00074 378753001975 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 378753001976 AMP/PPi binding site [chemical binding]; other site 378753001977 candidate oxyanion hole; other site 378753001978 catalytic triad [active] 378753001979 potential glutamine specificity residues [chemical binding]; other site 378753001980 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 378753001981 ATP Binding subdomain [chemical binding]; other site 378753001982 Ligand Binding sites [chemical binding]; other site 378753001983 Dimerization subdomain; other site 378753001984 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 378753001985 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 378753001986 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 378753001987 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 378753001988 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 378753001989 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 378753001990 active site 378753001991 tetramer interface; other site 378753001992 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378753001993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 378753001994 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 378753001995 putative active site; other site 378753001996 putative metal binding residues [ion binding]; other site 378753001997 signature motif; other site 378753001998 putative triphosphate binding site [ion binding]; other site 378753001999 CHAD domain; Region: CHAD; pfam05235 378753002000 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753002001 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753002002 putative substrate translocation pore; other site 378753002003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753002004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753002005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753002006 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753002007 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 378753002008 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753002009 active site 378753002010 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 378753002011 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 378753002012 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 378753002013 metal binding site [ion binding]; metal-binding site 378753002014 dimer interface [polypeptide binding]; other site 378753002015 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 378753002016 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 378753002017 metal binding site [ion binding]; metal-binding site 378753002018 dimer interface [polypeptide binding]; other site 378753002019 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 378753002020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753002021 dimerization interface [polypeptide binding]; other site 378753002022 putative DNA binding site [nucleotide binding]; other site 378753002023 putative Zn2+ binding site [ion binding]; other site 378753002024 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 378753002025 putative substrate binding pocket [chemical binding]; other site 378753002026 AC domain interface; other site 378753002027 catalytic triad [active] 378753002028 AB domain interface; other site 378753002029 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 378753002030 Mechanosensitive ion channel; Region: MS_channel; pfam00924 378753002031 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 378753002032 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 378753002033 oligomer interface [polypeptide binding]; other site 378753002034 metal binding site [ion binding]; metal-binding site 378753002035 metal binding site [ion binding]; metal-binding site 378753002036 putative Cl binding site [ion binding]; other site 378753002037 basic sphincter; other site 378753002038 hydrophobic gate; other site 378753002039 periplasmic entrance; other site 378753002040 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 378753002041 nudix motif; other site 378753002042 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 378753002043 aminotransferase AlaT; Validated; Region: PRK09265 378753002044 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753002045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753002046 homodimer interface [polypeptide binding]; other site 378753002047 catalytic residue [active] 378753002048 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 378753002049 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 378753002050 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 378753002051 generic binding surface II; other site 378753002052 generic binding surface I; other site 378753002053 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 378753002054 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 378753002055 RmuC family; Region: RmuC; pfam02646 378753002056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753002057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753002058 active site 378753002059 phosphorylation site [posttranslational modification] 378753002060 intermolecular recognition site; other site 378753002061 dimerization interface [polypeptide binding]; other site 378753002062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753002063 DNA binding residues [nucleotide binding] 378753002064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378753002065 Histidine kinase; Region: HisKA_3; pfam07730 378753002066 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378753002067 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 378753002068 Walker A/P-loop; other site 378753002069 ATP binding site [chemical binding]; other site 378753002070 Q-loop/lid; other site 378753002071 ABC transporter signature motif; other site 378753002072 Walker B; other site 378753002073 D-loop; other site 378753002074 H-loop/switch region; other site 378753002075 GTP-binding protein YchF; Reviewed; Region: PRK09601 378753002076 YchF GTPase; Region: YchF; cd01900 378753002077 G1 box; other site 378753002078 GTP/Mg2+ binding site [chemical binding]; other site 378753002079 Switch I region; other site 378753002080 G2 box; other site 378753002081 Switch II region; other site 378753002082 G3 box; other site 378753002083 G4 box; other site 378753002084 G5 box; other site 378753002085 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 378753002086 H+ Antiporter protein; Region: 2A0121; TIGR00900 378753002087 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753002088 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 378753002089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 378753002090 dimer interface [polypeptide binding]; other site 378753002091 putative metal binding site [ion binding]; other site 378753002092 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753002093 Coenzyme A binding pocket [chemical binding]; other site 378753002094 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 378753002095 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 378753002096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378753002097 non-specific DNA binding site [nucleotide binding]; other site 378753002098 salt bridge; other site 378753002099 sequence-specific DNA binding site [nucleotide binding]; other site 378753002100 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 378753002101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753002102 Coenzyme A binding pocket [chemical binding]; other site 378753002103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753002104 WHG domain; Region: WHG; pfam13305 378753002105 Helix-turn-helix domain; Region: HTH_28; pfam13518 378753002106 Winged helix-turn helix; Region: HTH_29; pfam13551 378753002107 Integrase core domain; Region: rve; pfam00665 378753002108 Integrase core domain; Region: rve_3; pfam13683 378753002109 Homeodomain-like domain; Region: HTH_23; cl17451 378753002110 Winged helix-turn helix; Region: HTH_29; pfam13551 378753002111 Integrase core domain; Region: rve; pfam00665 378753002112 Integrase core domain; Region: rve_3; pfam13683 378753002113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753002114 AAA domain; Region: AAA_23; pfam13476 378753002115 Walker A/P-loop; other site 378753002116 ATP binding site [chemical binding]; other site 378753002117 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 378753002118 putative active site [active] 378753002119 putative metal-binding site [ion binding]; other site 378753002120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753002121 dimerization interface [polypeptide binding]; other site 378753002122 putative DNA binding site [nucleotide binding]; other site 378753002123 putative Zn2+ binding site [ion binding]; other site 378753002124 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 378753002125 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378753002126 Homeodomain-like domain; Region: HTH_23; cl17451 378753002127 Winged helix-turn helix; Region: HTH_29; pfam13551 378753002128 Integrase core domain; Region: rve; pfam00665 378753002129 Integrase core domain; Region: rve_3; pfam13683 378753002130 Abi-like protein; Region: Abi_2; pfam07751 378753002131 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 378753002132 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 378753002133 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 378753002134 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 378753002135 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 378753002136 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 378753002137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 378753002138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378753002139 non-specific DNA binding site [nucleotide binding]; other site 378753002140 salt bridge; other site 378753002141 sequence-specific DNA binding site [nucleotide binding]; other site 378753002142 5-methylcytosine-specific restriction enzyme subunit McrC; Provisional; Region: PRK09736 378753002143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753002144 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 378753002145 Walker A motif; other site 378753002146 ATP binding site [chemical binding]; other site 378753002147 Walker B motif; other site 378753002148 arginine finger; other site 378753002149 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 378753002150 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 378753002151 transmembrane helices; other site 378753002152 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 378753002153 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 378753002154 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 378753002155 L-aspartate oxidase; Provisional; Region: PRK06175 378753002156 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 378753002157 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 378753002158 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 378753002159 putative Iron-sulfur protein interface [polypeptide binding]; other site 378753002160 proximal heme binding site [chemical binding]; other site 378753002161 distal heme binding site [chemical binding]; other site 378753002162 putative dimer interface [polypeptide binding]; other site 378753002163 L-lactate permease; Region: Lactate_perm; cl00701 378753002164 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 378753002165 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378753002166 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378753002167 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 378753002168 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 378753002169 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 378753002170 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 378753002171 active site 378753002172 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 378753002173 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378753002174 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 378753002175 NAD binding site [chemical binding]; other site 378753002176 substrate binding site [chemical binding]; other site 378753002177 catalytic Zn binding site [ion binding]; other site 378753002178 tetramer interface [polypeptide binding]; other site 378753002179 structural Zn binding site [ion binding]; other site 378753002180 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 378753002181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753002182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753002183 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 378753002184 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 378753002185 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378753002186 active site 378753002187 catalytic site [active] 378753002188 Lamin Tail Domain; Region: LTD; pfam00932 378753002189 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 378753002190 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 378753002191 Pleckstrin homology-like domain; Region: PH-like; cl17171 378753002192 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378753002193 active site 378753002194 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227 378753002195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753002196 S-adenosylmethionine binding site [chemical binding]; other site 378753002197 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 378753002198 FMN binding site [chemical binding]; other site 378753002199 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 378753002200 dimer interface [polypeptide binding]; other site 378753002201 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 378753002202 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 378753002203 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 378753002204 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 378753002205 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 378753002206 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 378753002207 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 378753002208 molybdopterin cofactor binding site; other site 378753002209 4Fe-4S dicluster domain; Region: Fer4_11; pfam13247 378753002210 4Fe-4S binding domain; Region: Fer4_6; pfam12837 378753002211 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 378753002212 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 378753002213 dimerization interface [polypeptide binding]; other site 378753002214 putative ATP binding site [chemical binding]; other site 378753002215 selenocysteine synthase; Provisional; Region: PRK04311 378753002216 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753002217 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 378753002218 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 378753002219 G1 box; other site 378753002220 putative GEF interaction site [polypeptide binding]; other site 378753002221 GTP/Mg2+ binding site [chemical binding]; other site 378753002222 Switch I region; other site 378753002223 G2 box; other site 378753002224 G3 box; other site 378753002225 Switch II region; other site 378753002226 G4 box; other site 378753002227 G5 box; other site 378753002228 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 378753002229 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 378753002230 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 378753002231 acyl-CoA esterase; Provisional; Region: PRK10673 378753002232 PGAP1-like protein; Region: PGAP1; pfam07819 378753002233 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 378753002234 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 378753002235 active site 378753002236 SUMO-1 interface [polypeptide binding]; other site 378753002237 Carboxylesterase family; Region: COesterase; pfam00135 378753002238 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 378753002239 substrate binding pocket [chemical binding]; other site 378753002240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 378753002241 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753002242 Coenzyme A binding pocket [chemical binding]; other site 378753002243 UPF0126 domain; Region: UPF0126; pfam03458 378753002244 Predicted membrane protein [Function unknown]; Region: COG2860 378753002245 UPF0126 domain; Region: UPF0126; pfam03458 378753002246 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 378753002247 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 378753002248 active site residue [active] 378753002249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 378753002250 MOSC domain; Region: MOSC; pfam03473 378753002251 3-alpha domain; Region: 3-alpha; pfam03475 378753002252 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 378753002253 Fe-S cluster binding site [ion binding]; other site 378753002254 DNA binding site [nucleotide binding] 378753002255 active site 378753002256 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 378753002257 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 378753002258 putative ADP-ribose binding site [chemical binding]; other site 378753002259 putative active site [active] 378753002260 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753002261 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753002262 Coenzyme A binding pocket [chemical binding]; other site 378753002263 malate dehydrogenase; Provisional; Region: PRK05442 378753002264 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 378753002265 NAD(P) binding site [chemical binding]; other site 378753002266 dimer interface [polypeptide binding]; other site 378753002267 malate binding site [chemical binding]; other site 378753002268 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 378753002269 dimer interface [polypeptide binding]; other site 378753002270 catalytic triad [active] 378753002271 peroxidatic and resolving cysteines [active] 378753002272 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 378753002273 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 378753002274 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 378753002275 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 378753002276 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 378753002277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 378753002278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 378753002279 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 378753002280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753002281 ABC-ATPase subunit interface; other site 378753002282 putative PBP binding loops; other site 378753002283 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 378753002284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 378753002285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753002286 dimer interface [polypeptide binding]; other site 378753002287 conserved gate region; other site 378753002288 putative PBP binding loops; other site 378753002289 ABC-ATPase subunit interface; other site 378753002290 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 378753002291 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 378753002292 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 378753002293 Walker A/P-loop; other site 378753002294 ATP binding site [chemical binding]; other site 378753002295 Q-loop/lid; other site 378753002296 ABC transporter signature motif; other site 378753002297 Walker B; other site 378753002298 D-loop; other site 378753002299 H-loop/switch region; other site 378753002300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 378753002301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 378753002302 Walker A/P-loop; other site 378753002303 ATP binding site [chemical binding]; other site 378753002304 Q-loop/lid; other site 378753002305 ABC transporter signature motif; other site 378753002306 Walker B; other site 378753002307 D-loop; other site 378753002308 H-loop/switch region; other site 378753002309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378753002310 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 378753002311 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 378753002312 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 378753002313 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 378753002314 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 378753002315 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 378753002316 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 378753002317 GatB domain; Region: GatB_Yqey; smart00845 378753002318 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 378753002319 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 378753002320 putative active site [active] 378753002321 putative metal binding site [ion binding]; other site 378753002322 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 378753002323 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 378753002324 AzlC protein; Region: AzlC; cl00570 378753002325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378753002326 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 378753002327 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 378753002328 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 378753002329 G1 box; other site 378753002330 putative GEF interaction site [polypeptide binding]; other site 378753002331 GTP/Mg2+ binding site [chemical binding]; other site 378753002332 Switch I region; other site 378753002333 G2 box; other site 378753002334 G3 box; other site 378753002335 Switch II region; other site 378753002336 G4 box; other site 378753002337 G5 box; other site 378753002338 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 378753002339 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 378753002340 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 378753002341 Ferredoxin [Energy production and conversion]; Region: COG1146 378753002342 4Fe-4S binding domain; Region: Fer4; pfam00037 378753002343 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 378753002344 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753002345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753002346 homodimer interface [polypeptide binding]; other site 378753002347 catalytic residue [active] 378753002348 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 378753002349 dimer interface [polypeptide binding]; other site 378753002350 Citrate synthase; Region: Citrate_synt; pfam00285 378753002351 active site 378753002352 citrylCoA binding site [chemical binding]; other site 378753002353 NADH binding [chemical binding]; other site 378753002354 cationic pore residues; other site 378753002355 oxalacetate/citrate binding site [chemical binding]; other site 378753002356 coenzyme A binding site [chemical binding]; other site 378753002357 catalytic triad [active] 378753002358 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 378753002359 UDP-glucose 4-epimerase; Region: PLN02240 378753002360 NAD binding site [chemical binding]; other site 378753002361 homodimer interface [polypeptide binding]; other site 378753002362 active site 378753002363 substrate binding site [chemical binding]; other site 378753002364 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 378753002365 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 378753002366 putative trimer interface [polypeptide binding]; other site 378753002367 putative CoA binding site [chemical binding]; other site 378753002368 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 378753002369 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 378753002370 metal binding site [ion binding]; metal-binding site 378753002371 putative dimer interface [polypeptide binding]; other site 378753002372 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 378753002373 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 378753002374 CrcB-like protein; Region: CRCB; cl09114 378753002375 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 378753002376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753002377 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 378753002378 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 378753002379 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 378753002380 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 378753002381 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 378753002382 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 378753002383 MgtE intracellular N domain; Region: MgtE_N; smart00924 378753002384 FOG: CBS domain [General function prediction only]; Region: COG0517 378753002385 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 378753002386 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 378753002387 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 378753002388 active site 378753002389 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 378753002390 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 378753002391 active site 378753002392 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 378753002393 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 378753002394 DNA methylase; Region: N6_N4_Mtase; pfam01555 378753002395 helicase 45; Provisional; Region: PTZ00424 378753002396 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 378753002397 ATP binding site [chemical binding]; other site 378753002398 Mg++ binding site [ion binding]; other site 378753002399 motif III; other site 378753002400 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753002401 nucleotide binding region [chemical binding]; other site 378753002402 ATP-binding site [chemical binding]; other site 378753002403 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 378753002404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753002405 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753002406 WHG domain; Region: WHG; pfam13305 378753002407 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 378753002408 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 378753002409 NAD(P) binding pocket [chemical binding]; other site 378753002410 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 378753002411 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 378753002412 substrate binding site [chemical binding]; other site 378753002413 active site 378753002414 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753002415 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 378753002416 Chlorite dismutase; Region: Chlor_dismutase; cl01280 378753002417 ferrochelatase; Reviewed; Region: hemH; PRK00035 378753002418 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 378753002419 C-terminal domain interface [polypeptide binding]; other site 378753002420 active site 378753002421 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 378753002422 active site 378753002423 N-terminal domain interface [polypeptide binding]; other site 378753002424 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 378753002425 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 378753002426 domain interfaces; other site 378753002427 active site 378753002428 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 378753002429 active site 378753002430 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 378753002431 dimer interface [polypeptide binding]; other site 378753002432 active site 378753002433 Schiff base residues; other site 378753002434 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 378753002435 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 378753002436 inhibitor-cofactor binding pocket; inhibition site 378753002437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753002438 catalytic residue [active] 378753002439 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 378753002440 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 378753002441 active site 378753002442 catalytic site [active] 378753002443 substrate binding site [chemical binding]; other site 378753002444 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 378753002445 Part of AAA domain; Region: AAA_19; pfam13245 378753002446 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 378753002447 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 378753002448 Part of AAA domain; Region: AAA_19; pfam13245 378753002449 Family description; Region: UvrD_C_2; pfam13538 378753002450 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 378753002451 Phosphotransferase enzyme family; Region: APH; pfam01636 378753002452 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 378753002453 active site 378753002454 ATP binding site [chemical binding]; other site 378753002455 substrate binding site [chemical binding]; other site 378753002456 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 378753002457 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 378753002458 putative NADH binding site [chemical binding]; other site 378753002459 putative active site [active] 378753002460 nudix motif; other site 378753002461 putative metal binding site [ion binding]; other site 378753002462 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 378753002463 Part of AAA domain; Region: AAA_19; pfam13245 378753002464 Family description; Region: UvrD_C_2; pfam13538 378753002465 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378753002466 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 378753002467 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 378753002468 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 378753002469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 378753002470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 378753002471 DNA binding site [nucleotide binding] 378753002472 domain linker motif; other site 378753002473 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 378753002474 Protein of unknown function DUF45; Region: DUF45; cl00636 378753002475 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 378753002476 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 378753002477 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 378753002478 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 378753002479 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 378753002480 Uncharacterized conserved protein [Function unknown]; Region: COG1615 378753002481 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 378753002482 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 378753002483 Repair protein; Region: Repair_PSII; pfam04536 378753002484 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 378753002485 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 378753002486 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 378753002487 protein binding site [polypeptide binding]; other site 378753002488 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 378753002489 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 378753002490 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 378753002491 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753002492 catalytic residue [active] 378753002493 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 378753002494 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 378753002495 chorismate mutase; Provisional; Region: PRK09239 378753002496 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 378753002497 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378753002498 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753002499 active site 378753002500 phosphorylation site [posttranslational modification] 378753002501 intermolecular recognition site; other site 378753002502 dimerization interface [polypeptide binding]; other site 378753002503 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 378753002504 DNA binding site [nucleotide binding] 378753002505 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 378753002506 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 378753002507 dimerization interface [polypeptide binding]; other site 378753002508 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 378753002509 dimer interface [polypeptide binding]; other site 378753002510 phosphorylation site [posttranslational modification] 378753002511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753002512 ATP binding site [chemical binding]; other site 378753002513 Mg2+ binding site [ion binding]; other site 378753002514 G-X-G motif; other site 378753002515 lipoprotein LpqB; Provisional; Region: PRK13614 378753002516 Sporulation and spore germination; Region: Germane; pfam10646 378753002517 comF family protein; Region: comF; TIGR00201 378753002518 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753002519 active site 378753002520 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 378753002521 30S subunit binding site; other site 378753002522 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 378753002523 DEAD/DEAH box helicase; Region: DEAD; pfam00270 378753002524 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 378753002525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 378753002526 nucleotide binding region [chemical binding]; other site 378753002527 cell division suppressor protein YneA; Provisional; Region: PRK14125 378753002528 Helix-turn-helix domain; Region: HTH_17; pfam12728 378753002529 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 378753002530 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 378753002531 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 378753002532 Histidine kinase; Region: HisKA_2; pfam07568 378753002533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753002534 ATP binding site [chemical binding]; other site 378753002535 G-X-G motif; other site 378753002536 Transcription factor WhiB; Region: Whib; pfam02467 378753002537 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 378753002538 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 378753002539 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753002540 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 378753002541 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753002542 UDP-galactopyranose mutase; Region: GLF; pfam03275 378753002543 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 378753002544 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753002545 active site 378753002546 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 378753002547 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 378753002548 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 378753002549 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 378753002550 Walker A/P-loop; other site 378753002551 ATP binding site [chemical binding]; other site 378753002552 Q-loop/lid; other site 378753002553 ABC transporter signature motif; other site 378753002554 Walker B; other site 378753002555 D-loop; other site 378753002556 H-loop/switch region; other site 378753002557 Predicted integral membrane protein [Function unknown]; Region: COG5617 378753002558 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 378753002559 Ligand binding site; other site 378753002560 Putative Catalytic site; other site 378753002561 DXD motif; other site 378753002562 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 378753002563 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 378753002564 tape measure domain; Region: tape_meas_nterm; TIGR02675 378753002565 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 378753002566 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 378753002567 catalytic residues [active] 378753002568 catalytic nucleophile [active] 378753002569 Presynaptic Site I dimer interface [polypeptide binding]; other site 378753002570 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 378753002571 Synaptic Flat tetramer interface [polypeptide binding]; other site 378753002572 Synaptic Site I dimer interface [polypeptide binding]; other site 378753002573 DNA binding site [nucleotide binding] 378753002574 Recombinase; Region: Recombinase; pfam07508 378753002575 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 378753002576 AAA domain; Region: AAA_25; pfam13481 378753002577 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 378753002578 polymerase nucleotide-binding site; other site 378753002579 DNA-binding residues [nucleotide binding]; DNA binding site 378753002580 nucleotide binding site [chemical binding]; other site 378753002581 primase nucleotide-binding site [nucleotide binding]; other site 378753002582 Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942 378753002583 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 378753002584 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 378753002585 catalytic residues [active] 378753002586 catalytic nucleophile [active] 378753002587 Recombinase; Region: Recombinase; pfam07508 378753002588 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 378753002589 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 378753002590 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 378753002591 Walker A motif; other site 378753002592 ATP binding site [chemical binding]; other site 378753002593 Walker B motif; other site 378753002594 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 378753002595 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 378753002596 ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448 378753002597 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 378753002598 ligand binding site; other site 378753002599 oligomer interface; other site 378753002600 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 378753002601 dimer interface [polypeptide binding]; other site 378753002602 N-terminal domain interface [polypeptide binding]; other site 378753002603 sulfate 1 binding site; other site 378753002604 peptide chain release factor 2; Validated; Region: prfB; PRK00578 378753002605 This domain is found in peptide chain release factors; Region: PCRF; smart00937 378753002606 RF-1 domain; Region: RF-1; pfam00472 378753002607 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 378753002608 SmpB-tmRNA interface; other site 378753002609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753002610 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 378753002611 Walker A/P-loop; other site 378753002612 ATP binding site [chemical binding]; other site 378753002613 Q-loop/lid; other site 378753002614 ABC transporter signature motif; other site 378753002615 Walker B; other site 378753002616 D-loop; other site 378753002617 H-loop/switch region; other site 378753002618 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 378753002619 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 378753002620 active site 378753002621 Predicted GTPases [General function prediction only]; Region: COG1162 378753002622 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 378753002623 GTPase/Zn-binding domain interface [polypeptide binding]; other site 378753002624 GTP/Mg2+ binding site [chemical binding]; other site 378753002625 G4 box; other site 378753002626 G5 box; other site 378753002627 G1 box; other site 378753002628 Switch I region; other site 378753002629 G2 box; other site 378753002630 G3 box; other site 378753002631 Switch II region; other site 378753002632 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 378753002633 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 378753002634 hinge; other site 378753002635 active site 378753002636 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 378753002637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378753002638 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 378753002639 DNA binding residues [nucleotide binding] 378753002640 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 378753002641 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 378753002642 active site 378753002643 catalytic triad [active] 378753002644 oxyanion hole [active] 378753002645 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 378753002646 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 378753002647 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 378753002648 TPP-binding site [chemical binding]; other site 378753002649 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 378753002650 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 378753002651 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 378753002652 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 378753002653 active site 378753002654 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 378753002655 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 378753002656 intersubunit interface [polypeptide binding]; other site 378753002657 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 378753002658 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753002659 Walker A/P-loop; other site 378753002660 ATP binding site [chemical binding]; other site 378753002661 Q-loop/lid; other site 378753002662 ABC transporter signature motif; other site 378753002663 Walker B; other site 378753002664 D-loop; other site 378753002665 H-loop/switch region; other site 378753002666 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 378753002667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 378753002668 putative PBP binding regions; other site 378753002669 ABC-ATPase subunit interface; other site 378753002670 diacylglycerol kinase; Reviewed; Region: PRK11914 378753002671 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 378753002672 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 378753002673 metal binding site 2 [ion binding]; metal-binding site 378753002674 putative DNA binding helix; other site 378753002675 metal binding site 1 [ion binding]; metal-binding site 378753002676 dimer interface [polypeptide binding]; other site 378753002677 structural Zn2+ binding site [ion binding]; other site 378753002678 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 378753002679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 378753002680 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 378753002681 nucleotide binding site/active site [active] 378753002682 HIT family signature motif; other site 378753002683 catalytic residue [active] 378753002684 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 378753002685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753002686 ATP binding site [chemical binding]; other site 378753002687 putative Mg++ binding site [ion binding]; other site 378753002688 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753002689 nucleotide binding region [chemical binding]; other site 378753002690 ATP-binding site [chemical binding]; other site 378753002691 Helicase associated domain (HA2); Region: HA2; pfam04408 378753002692 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 378753002693 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 378753002694 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 378753002695 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 378753002696 zinc binding site [ion binding]; other site 378753002697 putative ligand binding site [chemical binding]; other site 378753002698 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 378753002699 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 378753002700 TM-ABC transporter signature motif; other site 378753002701 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 378753002702 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753002703 Walker A/P-loop; other site 378753002704 ATP binding site [chemical binding]; other site 378753002705 Q-loop/lid; other site 378753002706 ABC transporter signature motif; other site 378753002707 Walker B; other site 378753002708 D-loop; other site 378753002709 H-loop/switch region; other site 378753002710 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 378753002711 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 378753002712 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 378753002713 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 378753002714 active site 378753002715 HIGH motif; other site 378753002716 KMSK motif region; other site 378753002717 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 378753002718 tRNA binding surface [nucleotide binding]; other site 378753002719 anticodon binding site; other site 378753002720 diaminopimelate decarboxylase; Region: lysA; TIGR01048 378753002721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 378753002722 active site 378753002723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378753002724 substrate binding site [chemical binding]; other site 378753002725 catalytic residues [active] 378753002726 dimer interface [polypeptide binding]; other site 378753002727 homoserine dehydrogenase; Provisional; Region: PRK06349 378753002728 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 378753002729 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 378753002730 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 378753002731 threonine synthase; Reviewed; Region: PRK06721 378753002732 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 378753002733 homodimer interface [polypeptide binding]; other site 378753002734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753002735 catalytic residue [active] 378753002736 homoserine kinase; Provisional; Region: PRK01212 378753002737 transcription termination factor Rho; Provisional; Region: PRK12608 378753002738 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 378753002739 RNA binding site [nucleotide binding]; other site 378753002740 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 378753002741 multimer interface [polypeptide binding]; other site 378753002742 Walker A motif; other site 378753002743 ATP binding site [chemical binding]; other site 378753002744 Walker B motif; other site 378753002745 peptide chain release factor 1; Validated; Region: prfA; PRK00591 378753002746 This domain is found in peptide chain release factors; Region: PCRF; smart00937 378753002747 RF-1 domain; Region: RF-1; pfam00472 378753002748 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 378753002749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753002750 S-adenosylmethionine binding site [chemical binding]; other site 378753002751 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 378753002752 extended (e) SDRs; Region: SDR_e; cd08946 378753002753 NAD(P) binding site [chemical binding]; other site 378753002754 active site 378753002755 substrate binding site [chemical binding]; other site 378753002756 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 378753002757 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753002758 active site 378753002759 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753002760 active site 378753002761 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 378753002762 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 378753002763 NAD(P) binding site [chemical binding]; other site 378753002764 homodimer interface [polypeptide binding]; other site 378753002765 substrate binding site [chemical binding]; other site 378753002766 active site 378753002767 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 378753002768 The members of this subfamily catalyze the formation of a phosphodiester bond between a membrane-associated undecaprenyl-phosphate (Und-P) molecule and N-acetylhexosamine 1-phosphate, which is usually donated by a soluble UDP-N-acetylhexosamine precursor; Region: GT_WbpL_WbcO_like; cd06854 378753002769 Mg++ binding site [ion binding]; other site 378753002770 putative catalytic motif [active] 378753002771 putative substrate binding site [chemical binding]; other site 378753002772 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 378753002773 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 378753002774 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 378753002775 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 378753002776 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 378753002777 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 378753002778 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 378753002779 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 378753002780 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 378753002781 beta subunit interaction interface [polypeptide binding]; other site 378753002782 Walker A motif; other site 378753002783 ATP binding site [chemical binding]; other site 378753002784 Walker B motif; other site 378753002785 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 378753002786 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 378753002787 core domain interface [polypeptide binding]; other site 378753002788 delta subunit interface [polypeptide binding]; other site 378753002789 epsilon subunit interface [polypeptide binding]; other site 378753002790 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 378753002791 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 378753002792 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 378753002793 alpha subunit interaction interface [polypeptide binding]; other site 378753002794 Walker A motif; other site 378753002795 ATP binding site [chemical binding]; other site 378753002796 Walker B motif; other site 378753002797 inhibitor binding site; inhibition site 378753002798 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 378753002799 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 378753002800 gamma subunit interface [polypeptide binding]; other site 378753002801 LBP interface [polypeptide binding]; other site 378753002802 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 378753002803 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 378753002804 hinge; other site 378753002805 active site 378753002806 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 378753002807 DNA-binding site [nucleotide binding]; DNA binding site 378753002808 RNA-binding motif; other site 378753002809 hypothetical protein; Provisional; Region: PRK03298 378753002810 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 378753002811 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 378753002812 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378753002813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 378753002814 binding surface 378753002815 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 378753002816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 378753002817 Walker A/P-loop; other site 378753002818 ATP binding site [chemical binding]; other site 378753002819 Q-loop/lid; other site 378753002820 ABC transporter signature motif; other site 378753002821 Walker B; other site 378753002822 D-loop; other site 378753002823 H-loop/switch region; other site 378753002824 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 378753002825 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 378753002826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753002827 ATP binding site [chemical binding]; other site 378753002828 putative Mg++ binding site [ion binding]; other site 378753002829 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 378753002830 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 378753002831 Isochorismatase family; Region: Isochorismatase; pfam00857 378753002832 catalytic triad [active] 378753002833 metal binding site [ion binding]; metal-binding site 378753002834 conserved cis-peptide bond; other site 378753002835 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 378753002836 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 378753002837 active site 378753002838 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 378753002839 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 378753002840 glutamate racemase; Provisional; Region: PRK00865 378753002841 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 378753002842 ribonuclease PH; Reviewed; Region: rph; PRK00173 378753002843 Ribonuclease PH; Region: RNase_PH_bact; cd11362 378753002844 hexamer interface [polypeptide binding]; other site 378753002845 active site 378753002846 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 378753002847 active site 378753002848 dimerization interface [polypeptide binding]; other site 378753002849 Phosphotransferase enzyme family; Region: APH; pfam01636 378753002850 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 378753002851 active site 378753002852 ATP binding site [chemical binding]; other site 378753002853 substrate binding site [chemical binding]; other site 378753002854 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 378753002855 active site 378753002856 catalytic site [active] 378753002857 substrate binding site [chemical binding]; other site 378753002858 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 378753002859 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 378753002860 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 378753002861 active site 378753002862 metal binding site [ion binding]; metal-binding site 378753002863 DNA binding site [nucleotide binding] 378753002864 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 378753002865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753002866 AAA domain; Region: AAA_23; pfam13476 378753002867 Walker A/P-loop; other site 378753002868 ATP binding site [chemical binding]; other site 378753002869 Q-loop/lid; other site 378753002870 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 378753002871 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753002872 ABC transporter signature motif; other site 378753002873 Walker B; other site 378753002874 D-loop; other site 378753002875 H-loop/switch region; other site 378753002876 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 378753002877 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 378753002878 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 378753002879 NAD binding site [chemical binding]; other site 378753002880 catalytic Zn binding site [ion binding]; other site 378753002881 substrate binding site [chemical binding]; other site 378753002882 structural Zn binding site [ion binding]; other site 378753002883 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 378753002884 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753002885 MarR family; Region: MarR; pfam01047 378753002886 MarR family; Region: MarR_2; cl17246 378753002887 malate:quinone oxidoreductase; Validated; Region: PRK05257 378753002888 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 378753002889 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 378753002890 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 378753002891 peptide binding site [polypeptide binding]; other site 378753002892 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 378753002893 catalytic triad [active] 378753002894 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753002895 MarR family; Region: MarR; pfam01047 378753002896 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 378753002897 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 378753002898 putative ligand binding site [chemical binding]; other site 378753002899 putative NAD binding site [chemical binding]; other site 378753002900 catalytic site [active] 378753002901 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 378753002902 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378753002903 PYR/PP interface [polypeptide binding]; other site 378753002904 dimer interface [polypeptide binding]; other site 378753002905 TPP binding site [chemical binding]; other site 378753002906 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378753002907 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 378753002908 TPP-binding site [chemical binding]; other site 378753002909 dimer interface [polypeptide binding]; other site 378753002910 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 378753002911 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 378753002912 putative valine binding site [chemical binding]; other site 378753002913 dimer interface [polypeptide binding]; other site 378753002914 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 378753002915 ketol-acid reductoisomerase; Provisional; Region: PRK05479 378753002916 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 378753002917 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 378753002918 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 378753002919 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 378753002920 active site 378753002921 HIGH motif; other site 378753002922 KMSKS motif; other site 378753002923 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 378753002924 tRNA binding surface [nucleotide binding]; other site 378753002925 anticodon binding site; other site 378753002926 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 378753002927 tartrate dehydrogenase; Region: TTC; TIGR02089 378753002928 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 378753002929 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 378753002930 homodimer interface [polypeptide binding]; other site 378753002931 substrate-cofactor binding pocket; other site 378753002932 catalytic residue [active] 378753002933 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 378753002934 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 378753002935 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 378753002936 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 378753002937 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 378753002938 HIGH motif; other site 378753002939 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 378753002940 active site 378753002941 KMSKS motif; other site 378753002942 Dynamin family; Region: Dynamin_N; pfam00350 378753002943 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 378753002944 G1 box; other site 378753002945 GTP/Mg2+ binding site [chemical binding]; other site 378753002946 G2 box; other site 378753002947 Switch I region; other site 378753002948 Dynamin family; Region: Dynamin_N; pfam00350 378753002949 YfjP GTPase; Region: YfjP; cd11383 378753002950 G1 box; other site 378753002951 GTP/Mg2+ binding site [chemical binding]; other site 378753002952 Switch I region; other site 378753002953 G2 box; other site 378753002954 Switch II region; other site 378753002955 G3 box; other site 378753002956 G4 box; other site 378753002957 G5 box; other site 378753002958 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 378753002959 Transcriptional regulator [Transcription]; Region: IclR; COG1414 378753002960 Bacterial transcriptional regulator; Region: IclR; pfam01614 378753002961 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 378753002962 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 378753002963 substrate binding site [chemical binding]; other site 378753002964 ligand binding site [chemical binding]; other site 378753002965 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 378753002966 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 378753002967 substrate binding site [chemical binding]; other site 378753002968 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 378753002969 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 378753002970 hinge; other site 378753002971 active site 378753002972 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 378753002973 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378753002974 putative acyl-acceptor binding pocket; other site 378753002975 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 378753002976 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 378753002977 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 378753002978 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 378753002979 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 378753002980 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 378753002981 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 378753002982 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 378753002983 ATP binding site [chemical binding]; other site 378753002984 dimerization interface [polypeptide binding]; other site 378753002985 DAK2 domain; Region: Dak2; pfam02734 378753002986 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 378753002987 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 378753002988 ssDNA binding site; other site 378753002989 generic binding surface II; other site 378753002990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753002991 ATP binding site [chemical binding]; other site 378753002992 putative Mg++ binding site [ion binding]; other site 378753002993 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753002994 nucleotide binding region [chemical binding]; other site 378753002995 ATP-binding site [chemical binding]; other site 378753002996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753002997 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 378753002998 aminotransferase; Validated; Region: PRK07777 378753002999 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753003000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753003001 homodimer interface [polypeptide binding]; other site 378753003002 catalytic residue [active] 378753003003 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 378753003004 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 378753003005 active site 378753003006 (T/H)XGH motif; other site 378753003007 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 378753003008 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 378753003009 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 378753003010 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 378753003011 dimerization interface [polypeptide binding]; other site 378753003012 active site 378753003013 metal binding site [ion binding]; metal-binding site 378753003014 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 378753003015 dsRNA binding site [nucleotide binding]; other site 378753003016 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 378753003017 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 378753003018 DNA binding site [nucleotide binding] 378753003019 catalytic residue [active] 378753003020 H2TH interface [polypeptide binding]; other site 378753003021 putative catalytic residues [active] 378753003022 turnover-facilitating residue; other site 378753003023 intercalation triad [nucleotide binding]; other site 378753003024 8OG recognition residue [nucleotide binding]; other site 378753003025 putative reading head residues; other site 378753003026 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 378753003027 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 378753003028 Phosphotransferase enzyme family; Region: APH; pfam01636 378753003029 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 378753003030 active site 378753003031 ATP binding site [chemical binding]; other site 378753003032 substrate binding site [chemical binding]; other site 378753003033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753003034 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 378753003035 NAD(P) binding site [chemical binding]; other site 378753003036 active site 378753003037 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378753003038 peptide synthase; Provisional; Region: PRK09274 378753003039 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753003040 acyl-activating enzyme (AAE) consensus motif; other site 378753003041 AMP binding site [chemical binding]; other site 378753003042 active site 378753003043 CoA binding site [chemical binding]; other site 378753003044 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 378753003045 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 378753003046 active site 378753003047 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 378753003048 AAA domain; Region: AAA_23; pfam13476 378753003049 Walker A/P-loop; other site 378753003050 ATP binding site [chemical binding]; other site 378753003051 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 378753003052 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 378753003053 ABC transporter signature motif; other site 378753003054 Walker B; other site 378753003055 D-loop; other site 378753003056 H-loop/switch region; other site 378753003057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753003058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753003059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753003060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753003061 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 378753003062 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 378753003063 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 378753003064 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 378753003065 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 378753003066 Nitrogen regulatory protein P-II; Region: P-II; smart00938 378753003067 signal recognition particle protein; Provisional; Region: PRK10867 378753003068 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 378753003069 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 378753003070 P loop; other site 378753003071 GTP binding site [chemical binding]; other site 378753003072 Signal peptide binding domain; Region: SRP_SPB; pfam02978 378753003073 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 378753003074 nudix motif; other site 378753003075 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 378753003076 hypothetical protein; Provisional; Region: PRK02821 378753003077 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 378753003078 G-X-X-G motif; other site 378753003079 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 378753003080 RimM N-terminal domain; Region: RimM; pfam01782 378753003081 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 378753003082 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 378753003083 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 378753003084 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 378753003085 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 378753003086 Catalytic site [active] 378753003087 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 378753003088 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 378753003089 Catalytic site [active] 378753003090 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 378753003091 RNA/DNA hybrid binding site [nucleotide binding]; other site 378753003092 active site 378753003093 hypothetical protein; Reviewed; Region: PRK12497 378753003094 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 378753003095 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 378753003096 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753003097 Walker A motif; other site 378753003098 ATP binding site [chemical binding]; other site 378753003099 Walker B motif; other site 378753003100 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 378753003101 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 378753003102 DNA protecting protein DprA; Region: dprA; TIGR00732 378753003103 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 378753003104 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378753003105 active site 378753003106 DNA binding site [nucleotide binding] 378753003107 Int/Topo IB signature motif; other site 378753003108 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 378753003109 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 378753003110 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 378753003111 dimer interface [polypeptide binding]; other site 378753003112 active site 378753003113 acyl carrier protein; Provisional; Region: acpP; PRK00982 378753003114 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 378753003115 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 378753003116 dimer interface [polypeptide binding]; other site 378753003117 active site 378753003118 CoA binding pocket [chemical binding]; other site 378753003119 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 378753003120 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 378753003121 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 378753003122 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 378753003123 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 378753003124 dimer interface [polypeptide binding]; other site 378753003125 TPP-binding site [chemical binding]; other site 378753003126 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 378753003127 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 378753003128 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378753003129 NAD-dependent deacetylase; Provisional; Region: PRK05333 378753003130 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 378753003131 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 378753003132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 378753003133 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 378753003134 active site 378753003135 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 378753003136 active site 378753003137 oligomerization interface [polypeptide binding]; other site 378753003138 metal binding site [ion binding]; metal-binding site 378753003139 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 378753003140 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 378753003141 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 378753003142 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 378753003143 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 378753003144 metal binding triad; other site 378753003145 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 378753003146 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 378753003147 metal binding triad; other site 378753003148 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 378753003149 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 378753003150 dimer interface [polypeptide binding]; other site 378753003151 ssDNA binding site [nucleotide binding]; other site 378753003152 tetramer (dimer of dimers) interface [polypeptide binding]; other site 378753003153 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 378753003154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753003155 Walker A/P-loop; other site 378753003156 ATP binding site [chemical binding]; other site 378753003157 Q-loop/lid; other site 378753003158 Cytochrome b562; Region: Cytochrom_B562; cl01546 378753003159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 378753003160 ABC transporter; Region: ABC_tran_2; pfam12848 378753003161 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 378753003162 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 378753003163 active site 378753003164 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 378753003165 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 378753003166 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 378753003167 IucA / IucC family; Region: IucA_IucC; pfam04183 378753003168 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 378753003169 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 378753003170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753003171 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 378753003172 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 378753003173 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753003174 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753003175 catalytic residue [active] 378753003176 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 378753003177 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 378753003178 FAD binding pocket [chemical binding]; other site 378753003179 FAD binding motif [chemical binding]; other site 378753003180 phosphate binding motif [ion binding]; other site 378753003181 NAD binding pocket [chemical binding]; other site 378753003182 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 378753003183 muropeptide transporter; Validated; Region: ampG; cl17669 378753003184 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 378753003185 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 378753003186 active site 378753003187 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 378753003188 catalytic triad [active] 378753003189 dimer interface [polypeptide binding]; other site 378753003190 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 378753003191 active site 378753003192 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 378753003193 apolar tunnel; other site 378753003194 heme binding site [chemical binding]; other site 378753003195 dimerization interface [polypeptide binding]; other site 378753003196 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 378753003197 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 378753003198 Zn binding site [ion binding]; other site 378753003199 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 378753003200 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 378753003201 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 378753003202 putative DNA binding site [nucleotide binding]; other site 378753003203 catalytic residue [active] 378753003204 putative H2TH interface [polypeptide binding]; other site 378753003205 putative catalytic residues [active] 378753003206 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 378753003207 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 378753003208 trigger factor; Provisional; Region: tig; PRK01490 378753003209 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 378753003210 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 378753003211 Clp protease; Region: CLP_protease; pfam00574 378753003212 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 378753003213 oligomer interface [polypeptide binding]; other site 378753003214 active site residues [active] 378753003215 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 378753003216 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 378753003217 oligomer interface [polypeptide binding]; other site 378753003218 active site residues [active] 378753003219 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 378753003220 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 378753003221 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 378753003222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753003223 Walker A motif; other site 378753003224 ATP binding site [chemical binding]; other site 378753003225 Walker B motif; other site 378753003226 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 378753003227 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 378753003228 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 378753003229 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378753003230 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 378753003231 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 378753003232 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378753003233 active site 378753003234 HIGH motif; other site 378753003235 nucleotide binding site [chemical binding]; other site 378753003236 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378753003237 active site 378753003238 KMSKS motif; other site 378753003239 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 378753003240 tRNA binding surface [nucleotide binding]; other site 378753003241 anticodon binding site; other site 378753003242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753003243 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 378753003244 NAD(P) binding site [chemical binding]; other site 378753003245 active site 378753003246 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 378753003247 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 378753003248 siderophore binding site; other site 378753003249 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 378753003250 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 378753003251 ABC-ATPase subunit interface; other site 378753003252 dimer interface [polypeptide binding]; other site 378753003253 putative PBP binding regions; other site 378753003254 FecCD transport family; Region: FecCD; pfam01032 378753003255 dimer interface [polypeptide binding]; other site 378753003256 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 378753003257 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 378753003258 Walker A/P-loop; other site 378753003259 ATP binding site [chemical binding]; other site 378753003260 Q-loop/lid; other site 378753003261 ABC transporter signature motif; other site 378753003262 Walker B; other site 378753003263 D-loop; other site 378753003264 H-loop/switch region; other site 378753003265 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 378753003266 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 378753003267 FAD binding pocket [chemical binding]; other site 378753003268 FAD binding motif [chemical binding]; other site 378753003269 phosphate binding motif [ion binding]; other site 378753003270 NAD binding pocket [chemical binding]; other site 378753003271 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 378753003272 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 378753003273 active site 378753003274 SAM binding site [chemical binding]; other site 378753003275 homodimer interface [polypeptide binding]; other site 378753003276 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 378753003277 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 378753003278 HIGH motif; other site 378753003279 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 378753003280 active site 378753003281 KMSKS motif; other site 378753003282 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 378753003283 tRNA binding surface [nucleotide binding]; other site 378753003284 anticodon binding site; other site 378753003285 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 378753003286 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378753003287 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378753003288 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 378753003289 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 378753003290 active site 378753003291 multimer interface [polypeptide binding]; other site 378753003292 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 378753003293 putative active site [active] 378753003294 redox center [active] 378753003295 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 378753003296 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 378753003297 homodimer interface [polypeptide binding]; other site 378753003298 oligonucleotide binding site [chemical binding]; other site 378753003299 multifunctional hydroxymethylpyrimidine phosphokinase/4-amino-5-aminomethyl-2-methylpyrimidine hydrolase; Provisional; Region: PRK14713 378753003300 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 378753003301 dimer interface [polypeptide binding]; other site 378753003302 substrate binding site [chemical binding]; other site 378753003303 ATP binding site [chemical binding]; other site 378753003304 Putative transcription activator [Transcription]; Region: TenA; COG0819 378753003305 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 378753003306 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 378753003307 GTPase CgtA; Reviewed; Region: obgE; PRK12296 378753003308 GTP1/OBG; Region: GTP1_OBG; pfam01018 378753003309 Obg GTPase; Region: Obg; cd01898 378753003310 G1 box; other site 378753003311 GTP/Mg2+ binding site [chemical binding]; other site 378753003312 Switch I region; other site 378753003313 G2 box; other site 378753003314 G3 box; other site 378753003315 Switch II region; other site 378753003316 G4 box; other site 378753003317 G5 box; other site 378753003318 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 378753003319 gamma-glutamyl kinase; Provisional; Region: PRK05429 378753003320 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 378753003321 nucleotide binding site [chemical binding]; other site 378753003322 homotetrameric interface [polypeptide binding]; other site 378753003323 putative phosphate binding site [ion binding]; other site 378753003324 putative allosteric binding site; other site 378753003325 PUA domain; Region: PUA; pfam01472 378753003326 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 378753003327 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 378753003328 putative catalytic cysteine [active] 378753003329 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 378753003330 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 378753003331 active site 378753003332 (T/H)XGH motif; other site 378753003333 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 378753003334 WbqC-like protein family; Region: WbqC; pfam08889 378753003335 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 378753003336 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753003337 AMP-binding enzyme; Region: AMP-binding; pfam00501 378753003338 acyl-activating enzyme (AAE) consensus motif; other site 378753003339 AMP binding site [chemical binding]; other site 378753003340 active site 378753003341 CoA binding site [chemical binding]; other site 378753003342 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 378753003343 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 378753003344 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 378753003345 putative trimer interface [polypeptide binding]; other site 378753003346 putative CoA binding site [chemical binding]; other site 378753003347 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 378753003348 putative trimer interface [polypeptide binding]; other site 378753003349 putative CoA binding site [chemical binding]; other site 378753003350 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 378753003351 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 378753003352 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 378753003353 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 378753003354 putative deacylase active site [active] 378753003355 Iron permease FTR1 family; Region: FTR1; cl00475 378753003356 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 378753003357 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 378753003358 Imelysin; Region: Peptidase_M75; pfam09375 378753003359 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 378753003360 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753003361 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753003362 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 378753003363 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 378753003364 active site 378753003365 PHP Thumb interface [polypeptide binding]; other site 378753003366 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 378753003367 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 378753003368 DNA polymerase III subunit alpha; Reviewed; Region: PRK07373 378753003369 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 378753003370 generic binding surface II; other site 378753003371 generic binding surface I; other site 378753003372 Uncharacterized conserved protein [Function unknown]; Region: COG4850 378753003373 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 378753003374 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 378753003375 catalytic residues [active] 378753003376 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 378753003377 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 378753003378 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 378753003379 Class I ribonucleotide reductase; Region: RNR_I; cd01679 378753003380 active site 378753003381 dimer interface [polypeptide binding]; other site 378753003382 catalytic residues [active] 378753003383 effector binding site; other site 378753003384 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 378753003385 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 378753003386 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 378753003387 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 378753003388 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 378753003389 active site 378753003390 catalytic residues [active] 378753003391 metal binding site [ion binding]; metal-binding site 378753003392 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 378753003393 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 378753003394 putative active site [active] 378753003395 substrate binding site [chemical binding]; other site 378753003396 putative cosubstrate binding site; other site 378753003397 catalytic site [active] 378753003398 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 378753003399 substrate binding site [chemical binding]; other site 378753003400 16S rRNA methyltransferase B; Provisional; Region: PRK14902 378753003401 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 378753003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753003403 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 378753003404 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 378753003405 substrate binding site [chemical binding]; other site 378753003406 hexamer interface [polypeptide binding]; other site 378753003407 metal binding site [ion binding]; metal-binding site 378753003408 Nicotinamide mononucleotide transporter [Coenzyme metabolism]; Region: PnuC; COG3201 378753003409 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 378753003410 catalytic motif [active] 378753003411 Zn binding site [ion binding]; other site 378753003412 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 378753003413 RibD C-terminal domain; Region: RibD_C; cl17279 378753003414 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 378753003415 Lumazine binding domain; Region: Lum_binding; pfam00677 378753003416 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 378753003417 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 378753003418 dimerization interface [polypeptide binding]; other site 378753003419 active site 378753003420 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 378753003421 homopentamer interface [polypeptide binding]; other site 378753003422 active site 378753003423 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 378753003424 homodimer interface [polypeptide binding]; other site 378753003425 putative metal binding site [ion binding]; other site 378753003426 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 378753003427 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 378753003428 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 378753003429 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 378753003430 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 378753003431 substrate binding site [chemical binding]; other site 378753003432 glutamase interaction surface [polypeptide binding]; other site 378753003433 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 378753003434 anthranilate synthase component I; Provisional; Region: PRK13571 378753003435 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 378753003436 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 378753003437 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 378753003438 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 378753003439 active site 378753003440 ribulose/triose binding site [chemical binding]; other site 378753003441 phosphate binding site [ion binding]; other site 378753003442 substrate (anthranilate) binding pocket [chemical binding]; other site 378753003443 product (indole) binding pocket [chemical binding]; other site 378753003444 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 378753003445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753003446 catalytic residue [active] 378753003447 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 378753003448 substrate binding site [chemical binding]; other site 378753003449 active site 378753003450 catalytic residues [active] 378753003451 heterodimer interface [polypeptide binding]; other site 378753003452 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 378753003453 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 378753003454 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 378753003455 active site 378753003456 dimer interface [polypeptide binding]; other site 378753003457 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 378753003458 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 378753003459 active site 378753003460 FMN binding site [chemical binding]; other site 378753003461 substrate binding site [chemical binding]; other site 378753003462 3Fe-4S cluster binding site [ion binding]; other site 378753003463 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 378753003464 domain interface; other site 378753003465 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 378753003466 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753003467 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 378753003468 pyruvate kinase; Provisional; Region: PRK06247 378753003469 domain interfaces; other site 378753003470 active site 378753003471 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 378753003472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753003473 active site 378753003474 phosphorylation site [posttranslational modification] 378753003475 intermolecular recognition site; other site 378753003476 dimerization interface [polypeptide binding]; other site 378753003477 ANTAR domain; Region: ANTAR; pfam03861 378753003478 DNA polymerase I; Provisional; Region: PRK05755 378753003479 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 378753003480 active site 378753003481 metal binding site 1 [ion binding]; metal-binding site 378753003482 putative 5' ssDNA interaction site; other site 378753003483 metal binding site 3; metal-binding site 378753003484 metal binding site 2 [ion binding]; metal-binding site 378753003485 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 378753003486 putative DNA binding site [nucleotide binding]; other site 378753003487 putative metal binding site [ion binding]; other site 378753003488 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 378753003489 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 378753003490 active site 378753003491 DNA binding site [nucleotide binding] 378753003492 catalytic site [active] 378753003493 hypothetical protein; Provisional; Region: PRK01346 378753003494 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 378753003495 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 378753003496 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 378753003497 RNA binding site [nucleotide binding]; other site 378753003498 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 378753003499 RNA binding site [nucleotide binding]; other site 378753003500 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 378753003501 RNA binding site [nucleotide binding]; other site 378753003502 S1 RNA binding domain; Region: S1; pfam00575 378753003503 RNA binding site [nucleotide binding]; other site 378753003504 Uncharacterized conserved protein [Function unknown]; Region: COG1739 378753003505 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 378753003506 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 378753003507 BCCT family transporter; Region: BCCT; pfam02028 378753003508 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 378753003509 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 378753003510 active site 378753003511 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 378753003512 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 378753003513 CoA-binding site [chemical binding]; other site 378753003514 ATP-binding [chemical binding]; other site 378753003515 excinuclease ABC subunit B; Provisional; Region: PRK05298 378753003516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 378753003517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753003518 nucleotide binding region [chemical binding]; other site 378753003519 ATP-binding site [chemical binding]; other site 378753003520 Ultra-violet resistance protein B; Region: UvrB; pfam12344 378753003521 UvrB/uvrC motif; Region: UVR; pfam02151 378753003522 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 378753003523 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 378753003524 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 378753003525 salt bridge; other site 378753003526 sequence-specific DNA binding site [nucleotide binding]; other site 378753003527 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753003528 ATP binding site [chemical binding]; other site 378753003529 putative Mg++ binding site [ion binding]; other site 378753003530 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753003531 nucleotide binding region [chemical binding]; other site 378753003532 ATP-binding site [chemical binding]; other site 378753003533 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 378753003534 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 378753003535 Sodium Bile acid symporter family; Region: SBF; pfam01758 378753003536 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 378753003537 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378753003538 MarR family; Region: MarR_2; pfam12802 378753003539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753003540 putative substrate translocation pore; other site 378753003541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753003542 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 378753003543 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 378753003544 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 378753003545 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 378753003546 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 378753003547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753003548 motif II; other site 378753003549 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378753003550 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 378753003551 putative acyl-acceptor binding pocket; other site 378753003552 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 378753003553 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 378753003554 GIY-YIG motif/motif A; other site 378753003555 active site 378753003556 catalytic site [active] 378753003557 putative DNA binding site [nucleotide binding]; other site 378753003558 metal binding site [ion binding]; metal-binding site 378753003559 UvrB/uvrC motif; Region: UVR; pfam02151 378753003560 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 378753003561 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 378753003562 AAA domain; Region: AAA_33; pfam13671 378753003563 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 378753003564 putative substrate binding pocket [chemical binding]; other site 378753003565 dimer interface [polypeptide binding]; other site 378753003566 phosphate binding site [ion binding]; other site 378753003567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 378753003568 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 378753003569 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 378753003570 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 378753003571 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 378753003572 Phosphoglycerate kinase; Region: PGK; pfam00162 378753003573 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 378753003574 substrate binding site [chemical binding]; other site 378753003575 hinge regions; other site 378753003576 ADP binding site [chemical binding]; other site 378753003577 catalytic site [active] 378753003578 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 378753003579 triosephosphate isomerase; Provisional; Region: PRK14565 378753003580 substrate binding site [chemical binding]; other site 378753003581 dimer interface [polypeptide binding]; other site 378753003582 catalytic triad [active] 378753003583 Preprotein translocase SecG subunit; Region: SecG; pfam03840 378753003584 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 378753003585 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 378753003586 putative active site [active] 378753003587 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 378753003588 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 378753003589 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 378753003590 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 378753003591 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 378753003592 bifunctional transaldolase/phosoglucose isomerase; Validated; Region: PRK09533 378753003593 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 378753003594 active site 378753003595 dimer interface [polypeptide binding]; other site 378753003596 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 378753003597 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 378753003598 putative active site [active] 378753003599 transaldolase; Provisional; Region: PRK03903 378753003600 catalytic residue [active] 378753003601 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 378753003602 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 378753003603 TPP-binding site [chemical binding]; other site 378753003604 dimer interface [polypeptide binding]; other site 378753003605 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 378753003606 PYR/PP interface [polypeptide binding]; other site 378753003607 dimer interface [polypeptide binding]; other site 378753003608 TPP binding site [chemical binding]; other site 378753003609 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378753003610 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 378753003611 UbiA prenyltransferase family; Region: UbiA; pfam01040 378753003612 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 378753003613 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 378753003614 inhibitor site; inhibition site 378753003615 active site 378753003616 dimer interface [polypeptide binding]; other site 378753003617 catalytic residue [active] 378753003618 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 378753003619 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 378753003620 ABC-2 type transporter; Region: ABC2_membrane; cl17235 378753003621 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 378753003622 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 378753003623 Walker A/P-loop; other site 378753003624 ATP binding site [chemical binding]; other site 378753003625 Q-loop/lid; other site 378753003626 ABC transporter signature motif; other site 378753003627 Walker B; other site 378753003628 D-loop; other site 378753003629 H-loop/switch region; other site 378753003630 Predicted transcriptional regulator [Transcription]; Region: COG2345 378753003631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753003632 putative DNA binding site [nucleotide binding]; other site 378753003633 putative Zn2+ binding site [ion binding]; other site 378753003634 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 378753003635 FeS assembly protein SufB; Region: sufB; TIGR01980 378753003636 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 378753003637 FeS assembly protein SufD; Region: sufD; TIGR01981 378753003638 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 378753003639 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 378753003640 Walker A/P-loop; other site 378753003641 ATP binding site [chemical binding]; other site 378753003642 Q-loop/lid; other site 378753003643 ABC transporter signature motif; other site 378753003644 Walker B; other site 378753003645 D-loop; other site 378753003646 H-loop/switch region; other site 378753003647 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 378753003648 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 378753003649 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 378753003650 phosphate binding site [ion binding]; other site 378753003651 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 378753003652 Cobalt transport protein; Region: CbiQ; cl00463 378753003653 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378753003654 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 378753003655 Walker A/P-loop; other site 378753003656 ATP binding site [chemical binding]; other site 378753003657 Q-loop/lid; other site 378753003658 ABC transporter signature motif; other site 378753003659 Walker B; other site 378753003660 D-loop; other site 378753003661 H-loop/switch region; other site 378753003662 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 378753003663 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 378753003664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753003665 Walker A/P-loop; other site 378753003666 ATP binding site [chemical binding]; other site 378753003667 Q-loop/lid; other site 378753003668 ABC transporter signature motif; other site 378753003669 Walker B; other site 378753003670 D-loop; other site 378753003671 H-loop/switch region; other site 378753003672 ABC transporter; Region: ABC_tran_2; pfam12848 378753003673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 378753003674 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 378753003675 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 378753003676 NAD(P) binding site [chemical binding]; other site 378753003677 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 378753003678 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 378753003679 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753003680 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 378753003681 NAD(P) binding site [chemical binding]; other site 378753003682 active site 378753003683 short chain dehydrogenase; Provisional; Region: PRK07806 378753003684 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 378753003685 NAD(P) binding site [chemical binding]; other site 378753003686 active site 378753003687 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 378753003688 MMPL family; Region: MMPL; pfam03176 378753003689 MMPL family; Region: MMPL; pfam03176 378753003690 phosphoserine phosphatase SerB; Region: serB; TIGR00338 378753003691 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753003692 motif II; other site 378753003693 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 378753003694 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 378753003695 Walker A/P-loop; other site 378753003696 ATP binding site [chemical binding]; other site 378753003697 ABC transporter signature motif; other site 378753003698 Walker B; other site 378753003699 D-loop; other site 378753003700 H-loop/switch region; other site 378753003701 hypothetical protein; Provisional; Region: PRK10621 378753003702 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 378753003703 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 378753003704 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 378753003705 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 378753003706 active site 378753003707 catalytic triad [active] 378753003708 LGFP repeat; Region: LGFP; pfam08310 378753003709 LGFP repeat; Region: LGFP; pfam08310 378753003710 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 378753003711 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 378753003712 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 378753003713 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 378753003714 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 378753003715 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753003716 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 378753003717 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 378753003718 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 378753003719 Walker A/P-loop; other site 378753003720 ATP binding site [chemical binding]; other site 378753003721 Q-loop/lid; other site 378753003722 ABC transporter signature motif; other site 378753003723 Walker B; other site 378753003724 D-loop; other site 378753003725 H-loop/switch region; other site 378753003726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 378753003727 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 378753003728 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 378753003729 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 378753003730 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 378753003731 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 378753003732 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 378753003733 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 378753003734 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 378753003735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 378753003736 active site 378753003737 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 378753003738 PEP-CTERM/exosortase A-associated glycosyltransferase, Daro_2409 family; Region: stp3; TIGR04063 378753003739 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 378753003740 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 378753003741 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 378753003742 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 378753003743 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 378753003744 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 378753003745 active site 378753003746 homodimer interface [polypeptide binding]; other site 378753003747 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 378753003748 ABC1 family; Region: ABC1; cl17513 378753003749 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 378753003750 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 378753003751 Zn binding site [ion binding]; other site 378753003752 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 378753003753 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 378753003754 ligand binding site; other site 378753003755 oligomer interface; other site 378753003756 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 378753003757 dimer interface [polypeptide binding]; other site 378753003758 N-terminal domain interface [polypeptide binding]; other site 378753003759 sulfate 1 binding site; other site 378753003760 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 378753003761 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 378753003762 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753003763 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753003764 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 378753003765 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 378753003766 YCII-related domain; Region: YCII; cl00999 378753003767 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 378753003768 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 378753003769 AsnC family; Region: AsnC_trans_reg; pfam01037 378753003770 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 378753003771 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 378753003772 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 378753003773 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 378753003774 Subunit I/III interface [polypeptide binding]; other site 378753003775 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 378753003776 Cytochrome c; Region: Cytochrom_C; pfam00034 378753003777 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 378753003778 Cytochrome c; Region: Cytochrom_C; pfam00034 378753003779 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 378753003780 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 378753003781 iron-sulfur cluster [ion binding]; other site 378753003782 [2Fe-2S] cluster binding site [ion binding]; other site 378753003783 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 378753003784 heme bH binding site [chemical binding]; other site 378753003785 Qi binding site; other site 378753003786 intrachain domain interface; other site 378753003787 heme bL binding site [chemical binding]; other site 378753003788 interchain domain interface [polypeptide binding]; other site 378753003789 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 378753003790 Qo binding site; other site 378753003791 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 378753003792 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 378753003793 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 378753003794 D-pathway; other site 378753003795 Putative ubiquinol binding site [chemical binding]; other site 378753003796 Low-spin heme (heme b) binding site [chemical binding]; other site 378753003797 Putative water exit pathway; other site 378753003798 Binuclear center (heme o3/CuB) [ion binding]; other site 378753003799 K-pathway; other site 378753003800 Putative proton exit pathway; other site 378753003801 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 378753003802 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 378753003803 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 378753003804 hypothetical protein; Provisional; Region: PRK07907 378753003805 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 378753003806 active site 378753003807 metal binding site [ion binding]; metal-binding site 378753003808 dimer interface [polypeptide binding]; other site 378753003809 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 378753003810 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 378753003811 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 378753003812 quinone interaction residues [chemical binding]; other site 378753003813 active site 378753003814 catalytic residues [active] 378753003815 FMN binding site [chemical binding]; other site 378753003816 substrate binding site [chemical binding]; other site 378753003817 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 378753003818 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 378753003819 catalytic residue [active] 378753003820 putative FPP diphosphate binding site; other site 378753003821 putative FPP binding hydrophobic cleft; other site 378753003822 dimer interface [polypeptide binding]; other site 378753003823 putative IPP diphosphate binding site; other site 378753003824 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 378753003825 Recombination protein O N terminal; Region: RecO_N; pfam11967 378753003826 Recombination protein O C terminal; Region: RecO_C; pfam02565 378753003827 2-isopropylmalate synthase; Validated; Region: PRK03739 378753003828 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 378753003829 active site 378753003830 catalytic residues [active] 378753003831 metal binding site [ion binding]; metal-binding site 378753003832 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 378753003833 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 378753003834 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 378753003835 GTPase Era; Reviewed; Region: era; PRK00089 378753003836 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 378753003837 G1 box; other site 378753003838 GTP/Mg2+ binding site [chemical binding]; other site 378753003839 Switch I region; other site 378753003840 G2 box; other site 378753003841 Switch II region; other site 378753003842 G3 box; other site 378753003843 G4 box; other site 378753003844 G5 box; other site 378753003845 KH domain; Region: KH_2; pfam07650 378753003846 metal-binding heat shock protein; Provisional; Region: PRK00016 378753003847 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 378753003848 PhoH-like protein; Region: PhoH; pfam02562 378753003849 Sporulation and spore germination; Region: Germane; pfam10646 378753003850 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 378753003851 chaperone protein DnaJ; Provisional; Region: PRK14278 378753003852 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 378753003853 HSP70 interaction site [polypeptide binding]; other site 378753003854 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 378753003855 substrate binding site [polypeptide binding]; other site 378753003856 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 378753003857 Zn binding sites [ion binding]; other site 378753003858 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 378753003859 dimer interface [polypeptide binding]; other site 378753003860 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 378753003861 HTH domain; Region: HTH_11; cl17392 378753003862 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 378753003863 Tic20-like protein; Region: Tic20; pfam09685 378753003864 coproporphyrinogen III oxidase; Validated; Region: PRK05628 378753003865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 378753003866 FeS/SAM binding site; other site 378753003867 HemN C-terminal domain; Region: HemN_C; pfam06969 378753003868 GTP-binding protein LepA; Provisional; Region: PRK05433 378753003869 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 378753003870 G1 box; other site 378753003871 putative GEF interaction site [polypeptide binding]; other site 378753003872 GTP/Mg2+ binding site [chemical binding]; other site 378753003873 Switch I region; other site 378753003874 G2 box; other site 378753003875 G3 box; other site 378753003876 Switch II region; other site 378753003877 G4 box; other site 378753003878 G5 box; other site 378753003879 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 378753003880 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 378753003881 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 378753003882 PemK-like protein; Region: PemK; pfam02452 378753003883 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 378753003884 hypothetical protein; Validated; Region: PRK05629 378753003885 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 378753003886 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 378753003887 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 378753003888 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 378753003889 active site 378753003890 FMN binding site [chemical binding]; other site 378753003891 substrate binding site [chemical binding]; other site 378753003892 homotetramer interface [polypeptide binding]; other site 378753003893 catalytic residue [active] 378753003894 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 378753003895 Competence protein; Region: Competence; pfam03772 378753003896 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 378753003897 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 378753003898 SLBB domain; Region: SLBB; pfam10531 378753003899 comEA protein; Region: comE; TIGR01259 378753003900 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 378753003901 leucine-zipper of insertion element IS481; Region: LZ_Tnp_IS481; pfam13011 378753003902 Winged helix-turn helix; Region: HTH_29; pfam13551 378753003903 Integrase core domain; Region: rve; pfam00665 378753003904 Integrase core domain; Region: rve_3; pfam13683 378753003905 EDD domain protein, DegV family; Region: DegV; TIGR00762 378753003906 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 378753003907 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 378753003908 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 378753003909 HIGH motif; other site 378753003910 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 378753003911 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378753003912 active site 378753003913 KMSKS motif; other site 378753003914 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 378753003915 tRNA binding surface [nucleotide binding]; other site 378753003916 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 378753003917 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378753003918 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 378753003919 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753003920 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 378753003921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753003922 dimer interface [polypeptide binding]; other site 378753003923 conserved gate region; other site 378753003924 putative PBP binding loops; other site 378753003925 ABC-ATPase subunit interface; other site 378753003926 NMT1-like family; Region: NMT1_2; pfam13379 378753003927 NMT1/THI5 like; Region: NMT1; pfam09084 378753003928 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378753003929 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 378753003930 Walker A/P-loop; other site 378753003931 ATP binding site [chemical binding]; other site 378753003932 Q-loop/lid; other site 378753003933 ABC transporter signature motif; other site 378753003934 Walker B; other site 378753003935 D-loop; other site 378753003936 H-loop/switch region; other site 378753003937 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753003938 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753003939 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 378753003940 primosome assembly protein PriA; Provisional; Region: PRK14873 378753003941 S-adenosylmethionine synthetase; Validated; Region: PRK05250 378753003942 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 378753003943 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 378753003944 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 378753003945 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 378753003946 Flavoprotein; Region: Flavoprotein; pfam02441 378753003947 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 378753003948 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 378753003949 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 378753003950 Guanylate kinase; Region: Guanylate_kin; pfam00625 378753003951 catalytic site [active] 378753003952 G-X2-G-X-G-K; other site 378753003953 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 378753003954 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 378753003955 active site 378753003956 dimer interface [polypeptide binding]; other site 378753003957 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 378753003958 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378753003959 ATP-grasp domain; Region: ATP-grasp_4; cl17255 378753003960 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 378753003961 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378753003962 ATP-grasp domain; Region: ATP-grasp_4; cl17255 378753003963 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 378753003964 IMP binding site; other site 378753003965 dimer interface [polypeptide binding]; other site 378753003966 interdomain contacts; other site 378753003967 partial ornithine binding site; other site 378753003968 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 378753003969 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 378753003970 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 378753003971 catalytic site [active] 378753003972 subunit interface [polypeptide binding]; other site 378753003973 dihydroorotase; Validated; Region: pyrC; PRK09357 378753003974 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 378753003975 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 378753003976 active site 378753003977 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 378753003978 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 378753003979 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 378753003980 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 378753003981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753003982 active site 378753003983 transcription antitermination factor NusB; Region: nusB; TIGR01951 378753003984 putative RNA binding site [nucleotide binding]; other site 378753003985 elongation factor P; Validated; Region: PRK00529 378753003986 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 378753003987 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 378753003988 RNA binding site [nucleotide binding]; other site 378753003989 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 378753003990 RNA binding site [nucleotide binding]; other site 378753003991 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 378753003992 active site 378753003993 dimer interface [polypeptide binding]; other site 378753003994 metal binding site [ion binding]; metal-binding site 378753003995 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 378753003996 shikimate kinase; Reviewed; Region: aroK; PRK00131 378753003997 ADP binding site [chemical binding]; other site 378753003998 magnesium binding site [ion binding]; other site 378753003999 putative shikimate binding site; other site 378753004000 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 378753004001 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 378753004002 Tetramer interface [polypeptide binding]; other site 378753004003 active site 378753004004 FMN-binding site [chemical binding]; other site 378753004005 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 378753004006 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 378753004007 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 378753004008 NAD(P) binding site [chemical binding]; other site 378753004009 shikimate binding site; other site 378753004010 YceG-like family; Region: YceG; pfam02618 378753004011 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 378753004012 dimerization interface [polypeptide binding]; other site 378753004013 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 378753004014 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 378753004015 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 378753004016 motif 1; other site 378753004017 active site 378753004018 motif 2; other site 378753004019 motif 3; other site 378753004020 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 378753004021 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 378753004022 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 378753004023 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378753004024 RNA binding surface [nucleotide binding]; other site 378753004025 glycerol kinase; Provisional; Region: glpK; PRK00047 378753004026 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 378753004027 N- and C-terminal domain interface [polypeptide binding]; other site 378753004028 active site 378753004029 MgATP binding site [chemical binding]; other site 378753004030 catalytic site [active] 378753004031 metal binding site [ion binding]; metal-binding site 378753004032 putative homotetramer interface [polypeptide binding]; other site 378753004033 glycerol binding site [chemical binding]; other site 378753004034 homodimer interface [polypeptide binding]; other site 378753004035 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 378753004036 amphipathic channel; other site 378753004037 Asn-Pro-Ala signature motifs; other site 378753004038 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 378753004039 recombination factor protein RarA; Reviewed; Region: PRK13342 378753004040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753004041 Walker A motif; other site 378753004042 ATP binding site [chemical binding]; other site 378753004043 Walker B motif; other site 378753004044 arginine finger; other site 378753004045 recombination factor protein RarA; Reviewed; Region: PRK13342 378753004046 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 378753004047 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 378753004048 putative active site [active] 378753004049 dimerization interface [polypeptide binding]; other site 378753004050 putative tRNAtyr binding site [nucleotide binding]; other site 378753004051 cyanate transporter; Region: CynX; TIGR00896 378753004052 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 378753004053 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 378753004054 dimer interface [polypeptide binding]; other site 378753004055 anticodon binding site; other site 378753004056 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 378753004057 homodimer interface [polypeptide binding]; other site 378753004058 motif 1; other site 378753004059 active site 378753004060 motif 2; other site 378753004061 GAD domain; Region: GAD; pfam02938 378753004062 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378753004063 active site 378753004064 motif 3; other site 378753004065 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 378753004066 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 378753004067 dimer interface [polypeptide binding]; other site 378753004068 motif 1; other site 378753004069 active site 378753004070 motif 2; other site 378753004071 motif 3; other site 378753004072 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 378753004073 anticodon binding site; other site 378753004074 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 378753004075 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 378753004076 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 378753004077 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378753004078 Zn2+ binding site [ion binding]; other site 378753004079 Mg2+ binding site [ion binding]; other site 378753004080 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 378753004081 synthetase active site [active] 378753004082 NTP binding site [chemical binding]; other site 378753004083 metal binding site [ion binding]; metal-binding site 378753004084 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 378753004085 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 378753004086 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 378753004087 Protein export membrane protein; Region: SecD_SecF; cl14618 378753004088 protein-export membrane protein SecD; Region: secD; TIGR01129 378753004089 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 378753004090 Preprotein translocase subunit; Region: YajC; cl00806 378753004091 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 378753004092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753004093 Walker A motif; other site 378753004094 ATP binding site [chemical binding]; other site 378753004095 Walker B motif; other site 378753004096 arginine finger; other site 378753004097 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 378753004098 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 378753004099 RuvA N terminal domain; Region: RuvA_N; pfam01330 378753004100 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 378753004101 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 378753004102 active site 378753004103 putative DNA-binding cleft [nucleotide binding]; other site 378753004104 dimer interface [polypeptide binding]; other site 378753004105 hypothetical protein; Validated; Region: PRK00110 378753004106 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 378753004107 catalytic triad [active] 378753004108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378753004109 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 378753004110 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 378753004111 nucleotide binding site/active site [active] 378753004112 HIT family signature motif; other site 378753004113 catalytic residue [active] 378753004114 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 378753004115 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 378753004116 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 378753004117 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 378753004118 active site 378753004119 dimer interface [polypeptide binding]; other site 378753004120 motif 1; other site 378753004121 motif 2; other site 378753004122 motif 3; other site 378753004123 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 378753004124 anticodon binding site; other site 378753004125 PRC-barrel domain; Region: PRC; pfam05239 378753004126 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 378753004127 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 378753004128 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 378753004129 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 378753004130 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 378753004131 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 378753004132 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 378753004133 Ligand binding site; other site 378753004134 Putative Catalytic site; other site 378753004135 DXD motif; other site 378753004136 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 378753004137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 378753004138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753004139 ATP binding site [chemical binding]; other site 378753004140 putative Mg++ binding site [ion binding]; other site 378753004141 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753004142 nucleotide binding region [chemical binding]; other site 378753004143 ATP-binding site [chemical binding]; other site 378753004144 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 378753004145 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 378753004146 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 378753004147 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 378753004148 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 378753004149 WYL domain; Region: WYL; pfam13280 378753004150 Predicted transcriptional regulator [Transcription]; Region: COG2378 378753004151 WYL domain; Region: WYL; pfam13280 378753004152 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 378753004153 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 378753004154 Pup-ligase protein; Region: Pup_ligase; cl15463 378753004155 Pup-like protein; Region: Pup; pfam05639 378753004156 Pup-ligase protein; Region: Pup_ligase; pfam03136 378753004157 proteasome ATPase; Region: pup_AAA; TIGR03689 378753004158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753004159 Walker A motif; other site 378753004160 ATP binding site [chemical binding]; other site 378753004161 Walker B motif; other site 378753004162 arginine finger; other site 378753004163 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 378753004164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753004165 S-adenosylmethionine binding site [chemical binding]; other site 378753004166 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 378753004167 active site 378753004168 putative substrate binding region [chemical binding]; other site 378753004169 PAC2 family; Region: PAC2; pfam09754 378753004170 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 378753004171 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 378753004172 active site 378753004173 HIGH motif; other site 378753004174 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378753004175 active site 378753004176 KMSKS motif; other site 378753004177 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 378753004178 tRNA binding surface [nucleotide binding]; other site 378753004179 anticodon binding site; other site 378753004180 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 378753004181 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753004182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753004183 hypothetical protein; Provisional; Region: PRK07906 378753004184 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 378753004185 putative metal binding site [ion binding]; other site 378753004186 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 378753004187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753004188 Coenzyme A binding pocket [chemical binding]; other site 378753004189 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 378753004190 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 378753004191 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 378753004192 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 378753004193 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 378753004194 dimer interface [polypeptide binding]; other site 378753004195 putative radical transfer pathway; other site 378753004196 diiron center [ion binding]; other site 378753004197 tyrosyl radical; other site 378753004198 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 378753004199 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 378753004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 378753004201 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 378753004202 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 378753004203 active site residue [active] 378753004204 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 378753004205 active site residue [active] 378753004206 Fe-S metabolism associated domain; Region: SufE; cl00951 378753004207 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 378753004208 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 378753004209 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 378753004210 SelR domain; Region: SelR; pfam01641 378753004211 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 378753004212 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 378753004213 catalytic site [active] 378753004214 putative active site [active] 378753004215 putative substrate binding site [chemical binding]; other site 378753004216 Helicase and RNase D C-terminal; Region: HRDC; smart00341 378753004217 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 378753004218 iron-sulfur cluster [ion binding]; other site 378753004219 [2Fe-2S] cluster binding site [ion binding]; other site 378753004220 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 378753004221 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 378753004222 TPP-binding site [chemical binding]; other site 378753004223 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 378753004224 PYR/PP interface [polypeptide binding]; other site 378753004225 dimer interface [polypeptide binding]; other site 378753004226 TPP binding site [chemical binding]; other site 378753004227 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378753004228 aconitate hydratase; Validated; Region: PRK09277 378753004229 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 378753004230 substrate binding site [chemical binding]; other site 378753004231 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 378753004232 ligand binding site [chemical binding]; other site 378753004233 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 378753004234 substrate binding site [chemical binding]; other site 378753004235 TRAM domain; Region: TRAM; pfam01938 378753004236 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 378753004237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753004238 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 378753004239 TrkA-N domain; Region: TrkA_N; pfam02254 378753004240 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 378753004241 TrkA-N domain; Region: TrkA_N; pfam02254 378753004242 TrkA-C domain; Region: TrkA_C; pfam02080 378753004243 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 378753004244 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 378753004245 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 378753004246 trimer interface [polypeptide binding]; other site 378753004247 active site 378753004248 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 378753004249 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 378753004250 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 378753004251 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 378753004252 PglZ domain; Region: PglZ; pfam08665 378753004253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378753004254 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378753004255 active site 378753004256 ATP binding site [chemical binding]; other site 378753004257 substrate binding site [chemical binding]; other site 378753004258 activation loop (A-loop); other site 378753004259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753004260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753004261 Coenzyme A binding pocket [chemical binding]; other site 378753004262 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 378753004263 CoA binding domain; Region: CoA_binding_2; pfam13380 378753004264 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 378753004265 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 378753004266 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 378753004267 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 378753004268 CAP-like domain; other site 378753004269 active site 378753004270 primary dimer interface [polypeptide binding]; other site 378753004271 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753004272 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 378753004273 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 378753004274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753004275 ATP binding site [chemical binding]; other site 378753004276 Mg2+ binding site [ion binding]; other site 378753004277 G-X-G motif; other site 378753004278 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 378753004279 anchoring element; other site 378753004280 dimer interface [polypeptide binding]; other site 378753004281 ATP binding site [chemical binding]; other site 378753004282 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 378753004283 active site 378753004284 metal binding site [ion binding]; metal-binding site 378753004285 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 378753004286 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 378753004287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753004288 S-adenosylmethionine binding site [chemical binding]; other site 378753004289 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 378753004290 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 378753004291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 378753004292 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 378753004293 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 378753004294 DNA binding residues [nucleotide binding] 378753004295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753004296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753004297 putative substrate translocation pore; other site 378753004298 PAC2 family; Region: PAC2; pfam09754 378753004299 multifunctional aminopeptidase A; Provisional; Region: PRK00913 378753004300 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 378753004301 interface (dimer of trimers) [polypeptide binding]; other site 378753004302 Substrate-binding/catalytic site; other site 378753004303 Zn-binding sites [ion binding]; other site 378753004304 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 378753004305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753004306 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378753004307 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378753004308 E3 interaction surface; other site 378753004309 lipoyl attachment site [posttranslational modification]; other site 378753004310 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; Region: SucB_Actino; TIGR02927 378753004311 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378753004312 E3 interaction surface; other site 378753004313 lipoyl attachment site [posttranslational modification]; other site 378753004314 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378753004315 E3 interaction surface; other site 378753004316 lipoyl attachment site [posttranslational modification]; other site 378753004317 e3 binding domain; Region: E3_binding; pfam02817 378753004318 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 378753004319 Protein kinase domain; Region: Pkinase; pfam00069 378753004320 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378753004321 active site 378753004322 ATP binding site [chemical binding]; other site 378753004323 substrate binding site [chemical binding]; other site 378753004324 lipoate-protein ligase B; Provisional; Region: PRK14345 378753004325 lipoyl synthase; Provisional; Region: PRK05481 378753004326 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 378753004327 FeS/SAM binding site; other site 378753004328 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 378753004329 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 378753004330 RDD family; Region: RDD; pfam06271 378753004331 glutamine synthetase, type I; Region: GlnA; TIGR00653 378753004332 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 378753004333 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 378753004334 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 378753004335 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 378753004336 catalytic site [active] 378753004337 putative active site [active] 378753004338 putative substrate binding site [chemical binding]; other site 378753004339 dimer interface [polypeptide binding]; other site 378753004340 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 378753004341 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378753004342 NAD binding site [chemical binding]; other site 378753004343 catalytic Zn binding site [ion binding]; other site 378753004344 structural Zn binding site [ion binding]; other site 378753004345 oxidoreductase; Provisional; Region: PRK06128 378753004346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753004347 NAD(P) binding site [chemical binding]; other site 378753004348 active site 378753004349 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753004350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753004351 active site 378753004352 phosphorylation site [posttranslational modification] 378753004353 intermolecular recognition site; other site 378753004354 dimerization interface [polypeptide binding]; other site 378753004355 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753004356 DNA binding residues [nucleotide binding] 378753004357 dimerization interface [polypeptide binding]; other site 378753004358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753004359 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753004360 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 378753004361 putative ADP-binding pocket [chemical binding]; other site 378753004362 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753004363 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 378753004364 active site 378753004365 catalytic residues [active] 378753004366 metal binding site [ion binding]; metal-binding site 378753004367 hypothetical protein; Validated; Region: PRK02101 378753004368 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 378753004369 Putative zinc ribbon domain; Region: DUF164; pfam02591 378753004370 Uncharacterized conserved protein [Function unknown]; Region: COG0327 378753004371 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 378753004372 methionine sulfoxide reductase A; Provisional; Region: PRK14054 378753004373 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 378753004374 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 378753004375 dimer interface [polypeptide binding]; other site 378753004376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753004377 catalytic residue [active] 378753004378 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 378753004379 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 378753004380 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 378753004381 trimer interface [polypeptide binding]; other site 378753004382 active site 378753004383 substrate binding site [chemical binding]; other site 378753004384 CoA binding site [chemical binding]; other site 378753004385 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 378753004386 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 378753004387 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 378753004388 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 378753004389 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 378753004390 ATP cone domain; Region: ATP-cone; pfam03477 378753004391 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 378753004392 histidinol dehydrogenase; Region: hisD; TIGR00069 378753004393 NAD binding site [chemical binding]; other site 378753004394 dimerization interface [polypeptide binding]; other site 378753004395 product binding site; other site 378753004396 substrate binding site [chemical binding]; other site 378753004397 zinc binding site [ion binding]; other site 378753004398 catalytic residues [active] 378753004399 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 378753004400 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 378753004401 active site 378753004402 PHP Thumb interface [polypeptide binding]; other site 378753004403 metal binding site [ion binding]; metal-binding site 378753004404 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 378753004405 generic binding surface II; other site 378753004406 generic binding surface I; other site 378753004407 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 378753004408 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 378753004409 active site 378753004410 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 378753004411 YGGT family; Region: YGGT; cl00508 378753004412 Protein of unknown function (DUF552); Region: DUF552; pfam04472 378753004413 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 378753004414 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 378753004415 catalytic residue [active] 378753004416 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 378753004417 cell division protein FtsZ; Validated; Region: PRK09330 378753004418 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 378753004419 nucleotide binding site [chemical binding]; other site 378753004420 SulA interaction site; other site 378753004421 cell division protein FtsQ; Provisional; Region: PRK05529 378753004422 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 378753004423 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 378753004424 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 378753004425 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378753004426 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378753004427 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 378753004428 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 378753004429 active site 378753004430 homodimer interface [polypeptide binding]; other site 378753004431 cell division protein FtsW; Region: ftsW; TIGR02614 378753004432 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 378753004433 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 378753004434 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378753004435 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378753004436 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 378753004437 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 378753004438 Mg++ binding site [ion binding]; other site 378753004439 putative catalytic motif [active] 378753004440 putative substrate binding site [chemical binding]; other site 378753004441 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 378753004442 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 378753004443 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378753004444 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378753004445 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 378753004446 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 378753004447 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 378753004448 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 378753004449 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 378753004450 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 378753004451 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 378753004452 MraW methylase family; Region: Methyltransf_5; cl17771 378753004453 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 378753004454 cell division protein MraZ; Reviewed; Region: PRK00326 378753004455 MraZ protein; Region: MraZ; pfam02381 378753004456 MraZ protein; Region: MraZ; pfam02381 378753004457 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 378753004458 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 378753004459 active site 378753004460 DNA polymerase IV; Validated; Region: PRK02406 378753004461 DNA binding site [nucleotide binding] 378753004462 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 378753004463 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 378753004464 substrate binding pocket [chemical binding]; other site 378753004465 chain length determination region; other site 378753004466 substrate-Mg2+ binding site; other site 378753004467 catalytic residues [active] 378753004468 aspartate-rich region 1; other site 378753004469 active site lid residues [active] 378753004470 aspartate-rich region 2; other site 378753004471 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 378753004472 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 378753004473 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 378753004474 N-acetyl-D-glucosamine binding site [chemical binding]; other site 378753004475 catalytic residue [active] 378753004476 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378753004477 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378753004478 active site 378753004479 ATP binding site [chemical binding]; other site 378753004480 substrate binding site [chemical binding]; other site 378753004481 activation loop (A-loop); other site 378753004482 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 378753004483 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 378753004484 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 378753004485 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 378753004486 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 378753004487 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378753004488 putative acyl-acceptor binding pocket; other site 378753004489 Esterase/lipase [General function prediction only]; Region: COG1647 378753004490 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 378753004491 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 378753004492 acyl-activating enzyme (AAE) consensus motif; other site 378753004493 putative AMP binding site [chemical binding]; other site 378753004494 putative active site [active] 378753004495 putative CoA binding site [chemical binding]; other site 378753004496 mycothione reductase; Reviewed; Region: PRK07846 378753004497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753004498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753004499 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378753004500 pyruvate carboxylase; Reviewed; Region: PRK12999 378753004501 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378753004502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 378753004503 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 378753004504 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 378753004505 active site 378753004506 catalytic residues [active] 378753004507 metal binding site [ion binding]; metal-binding site 378753004508 homodimer binding site [polypeptide binding]; other site 378753004509 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 378753004510 carboxyltransferase (CT) interaction site; other site 378753004511 biotinylation site [posttranslational modification]; other site 378753004512 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 378753004513 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 378753004514 Magnesium ion binding site [ion binding]; other site 378753004515 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 378753004516 DNA binding residues [nucleotide binding] 378753004517 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 378753004518 Bifunctional nuclease; Region: DNase-RNase; pfam02577 378753004519 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 378753004520 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 378753004521 DNA binding residues [nucleotide binding] 378753004522 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378753004523 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 378753004524 phosphopeptide binding site; other site 378753004525 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 378753004526 lipoyl attachment site [posttranslational modification]; other site 378753004527 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 378753004528 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 378753004529 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 378753004530 TrkA-N domain; Region: TrkA_N; pfam02254 378753004531 TrkA-C domain; Region: TrkA_C; pfam02080 378753004532 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 378753004533 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 378753004534 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 378753004535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753004536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753004537 homodimer interface [polypeptide binding]; other site 378753004538 catalytic residue [active] 378753004539 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 378753004540 GTP-binding protein Der; Reviewed; Region: PRK03003 378753004541 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 378753004542 G1 box; other site 378753004543 GTP/Mg2+ binding site [chemical binding]; other site 378753004544 Switch I region; other site 378753004545 G2 box; other site 378753004546 Switch II region; other site 378753004547 G3 box; other site 378753004548 G4 box; other site 378753004549 G5 box; other site 378753004550 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 378753004551 G1 box; other site 378753004552 GTP/Mg2+ binding site [chemical binding]; other site 378753004553 Switch I region; other site 378753004554 G2 box; other site 378753004555 G3 box; other site 378753004556 Switch II region; other site 378753004557 G4 box; other site 378753004558 G5 box; other site 378753004559 cytidylate kinase; Provisional; Region: cmk; PRK00023 378753004560 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 378753004561 CMP-binding site; other site 378753004562 The sites determining sugar specificity; other site 378753004563 prephenate dehydrogenase; Validated; Region: PRK06545 378753004564 prephenate dehydrogenase; Validated; Region: PRK08507 378753004565 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 378753004566 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 378753004567 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378753004568 RNA binding surface [nucleotide binding]; other site 378753004569 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 378753004570 active site 378753004571 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 378753004572 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 378753004573 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 378753004574 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 378753004575 P-loop; other site 378753004576 Magnesium ion binding site [ion binding]; other site 378753004577 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 378753004578 Magnesium ion binding site [ion binding]; other site 378753004579 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 378753004580 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 378753004581 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 378753004582 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753004583 acyl-activating enzyme (AAE) consensus motif; other site 378753004584 AMP binding site [chemical binding]; other site 378753004585 active site 378753004586 CoA binding site [chemical binding]; other site 378753004587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753004588 DNA-binding site [nucleotide binding]; DNA binding site 378753004589 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 378753004590 FCD domain; Region: FCD; pfam07729 378753004591 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 378753004592 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 378753004593 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 378753004594 tetramer interface [polypeptide binding]; other site 378753004595 active site 378753004596 Mg2+/Mn2+ binding site [ion binding]; other site 378753004597 citrate synthase; Provisional; Region: PRK14033 378753004598 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 378753004599 oxalacetate binding site [chemical binding]; other site 378753004600 citrylCoA binding site [chemical binding]; other site 378753004601 coenzyme A binding site [chemical binding]; other site 378753004602 catalytic triad [active] 378753004603 LGFP repeat; Region: LGFP; pfam08310 378753004604 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 378753004605 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 378753004606 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 378753004607 active site 378753004608 DNA binding site [nucleotide binding] 378753004609 Int/Topo IB signature motif; other site 378753004610 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 378753004611 dimer interface [polypeptide binding]; other site 378753004612 ADP-ribose binding site [chemical binding]; other site 378753004613 active site 378753004614 nudix motif; other site 378753004615 metal binding site [ion binding]; metal-binding site 378753004616 CTP synthetase; Validated; Region: pyrG; PRK05380 378753004617 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 378753004618 Catalytic site [active] 378753004619 active site 378753004620 UTP binding site [chemical binding]; other site 378753004621 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 378753004622 active site 378753004623 putative oxyanion hole; other site 378753004624 catalytic triad [active] 378753004625 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 378753004626 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753004627 Walker A/P-loop; other site 378753004628 ATP binding site [chemical binding]; other site 378753004629 Q-loop/lid; other site 378753004630 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 378753004631 ABC transporter signature motif; other site 378753004632 Walker B; other site 378753004633 D-loop; other site 378753004634 H-loop/switch region; other site 378753004635 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 378753004636 ATP-NAD kinase; Region: NAD_kinase; pfam01513 378753004637 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 378753004638 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378753004639 RNA binding surface [nucleotide binding]; other site 378753004640 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753004641 S-adenosylmethionine binding site [chemical binding]; other site 378753004642 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 378753004643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753004644 active site 378753004645 motif I; other site 378753004646 motif II; other site 378753004647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753004648 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 378753004649 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 378753004650 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 378753004651 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 378753004652 active site 378753004653 HIGH motif; other site 378753004654 dimer interface [polypeptide binding]; other site 378753004655 KMSKS motif; other site 378753004656 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378753004657 RNA binding surface [nucleotide binding]; other site 378753004658 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 378753004659 Part of AAA domain; Region: AAA_19; pfam13245 378753004660 Family description; Region: UvrD_C_2; pfam13538 378753004661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753004662 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 378753004663 active site 378753004664 DNA binding site [nucleotide binding] 378753004665 argininosuccinate lyase; Provisional; Region: PRK00855 378753004666 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 378753004667 active sites [active] 378753004668 tetramer interface [polypeptide binding]; other site 378753004669 argininosuccinate synthase; Provisional; Region: PRK13820 378753004670 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 378753004671 ANP binding site [chemical binding]; other site 378753004672 Substrate Binding Site II [chemical binding]; other site 378753004673 Substrate Binding Site I [chemical binding]; other site 378753004674 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 378753004675 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 378753004676 acyl-activating enzyme (AAE) consensus motif; other site 378753004677 putative AMP binding site [chemical binding]; other site 378753004678 putative active site [active] 378753004679 putative CoA binding site [chemical binding]; other site 378753004680 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 378753004681 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 378753004682 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 378753004683 arginine repressor; Provisional; Region: PRK03341 378753004684 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 378753004685 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 378753004686 ornithine carbamoyltransferase; Provisional; Region: PRK00779 378753004687 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 378753004688 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 378753004689 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 378753004690 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 378753004691 inhibitor-cofactor binding pocket; inhibition site 378753004692 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753004693 catalytic residue [active] 378753004694 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 378753004695 feedback inhibition sensing region; other site 378753004696 homohexameric interface [polypeptide binding]; other site 378753004697 nucleotide binding site [chemical binding]; other site 378753004698 N-acetyl-L-glutamate binding site [chemical binding]; other site 378753004699 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 378753004700 heterotetramer interface [polypeptide binding]; other site 378753004701 active site pocket [active] 378753004702 cleavage site 378753004703 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 378753004704 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 378753004705 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 378753004706 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 378753004707 NADP binding site [chemical binding]; other site 378753004708 dimer interface [polypeptide binding]; other site 378753004709 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 378753004710 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 378753004711 putative tRNA-binding site [nucleotide binding]; other site 378753004712 B3/4 domain; Region: B3_4; pfam03483 378753004713 tRNA synthetase B5 domain; Region: B5; smart00874 378753004714 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 378753004715 dimer interface [polypeptide binding]; other site 378753004716 motif 3; other site 378753004717 motif 2; other site 378753004718 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 378753004719 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 378753004720 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 378753004721 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 378753004722 dimer interface [polypeptide binding]; other site 378753004723 motif 1; other site 378753004724 active site 378753004725 motif 2; other site 378753004726 motif 3; other site 378753004727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753004728 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753004729 putative substrate translocation pore; other site 378753004730 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753004731 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 378753004732 active site 378753004733 8-oxo-dGMP binding site [chemical binding]; other site 378753004734 nudix motif; other site 378753004735 metal binding site [ion binding]; metal-binding site 378753004736 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 378753004737 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 378753004738 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 378753004739 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 378753004740 23S rRNA binding site [nucleotide binding]; other site 378753004741 L21 binding site [polypeptide binding]; other site 378753004742 L13 binding site [polypeptide binding]; other site 378753004743 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 378753004744 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 378753004745 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 378753004746 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 378753004747 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 378753004748 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 378753004749 catalytic residues [active] 378753004750 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 378753004751 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 378753004752 putative active site [active] 378753004753 oxyanion strand; other site 378753004754 catalytic triad [active] 378753004755 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 378753004756 4-fold oligomerization interface [polypeptide binding]; other site 378753004757 putative active site pocket [active] 378753004758 metal binding residues [ion binding]; metal-binding site 378753004759 3-fold/trimer interface [polypeptide binding]; other site 378753004760 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 378753004761 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753004762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753004763 homodimer interface [polypeptide binding]; other site 378753004764 catalytic residue [active] 378753004765 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 378753004766 LexA repressor; Validated; Region: PRK00215 378753004767 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753004768 putative DNA binding site [nucleotide binding]; other site 378753004769 putative Zn2+ binding site [ion binding]; other site 378753004770 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 378753004771 Catalytic site [active] 378753004772 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 378753004773 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 378753004774 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 378753004775 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 378753004776 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 378753004777 HflX GTPase family; Region: HflX; cd01878 378753004778 G1 box; other site 378753004779 GTP/Mg2+ binding site [chemical binding]; other site 378753004780 Switch I region; other site 378753004781 G2 box; other site 378753004782 G3 box; other site 378753004783 Switch II region; other site 378753004784 G4 box; other site 378753004785 G5 box; other site 378753004786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753004787 S-adenosylmethionine binding site [chemical binding]; other site 378753004788 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 378753004789 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 378753004790 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 378753004791 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 378753004792 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 378753004793 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 378753004794 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 378753004795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 378753004796 FeS/SAM binding site; other site 378753004797 recombination regulator RecX; Reviewed; Region: recX; PRK00117 378753004798 recombinase A; Provisional; Region: recA; PRK09354 378753004799 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 378753004800 hexamer interface [polypeptide binding]; other site 378753004801 Walker A motif; other site 378753004802 ATP binding site [chemical binding]; other site 378753004803 Walker B motif; other site 378753004804 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 378753004805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378753004806 non-specific DNA binding site [nucleotide binding]; other site 378753004807 salt bridge; other site 378753004808 sequence-specific DNA binding site [nucleotide binding]; other site 378753004809 Competence-damaged protein; Region: CinA; pfam02464 378753004810 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 378753004811 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 378753004812 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 378753004813 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 378753004814 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 378753004815 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 378753004816 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 378753004817 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 378753004818 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 378753004819 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 378753004820 dimer interface [polypeptide binding]; other site 378753004821 active site 378753004822 catalytic residue [active] 378753004823 dihydrodipicolinate reductase; Provisional; Region: PRK00048 378753004824 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 378753004825 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 378753004826 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 378753004827 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 378753004828 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 378753004829 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 378753004830 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 378753004831 oligomer interface [polypeptide binding]; other site 378753004832 RNA binding site [nucleotide binding]; other site 378753004833 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 378753004834 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 378753004835 RNase E interface [polypeptide binding]; other site 378753004836 trimer interface [polypeptide binding]; other site 378753004837 active site 378753004838 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 378753004839 putative nucleic acid binding region [nucleotide binding]; other site 378753004840 G-X-X-G motif; other site 378753004841 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 378753004842 RNA binding site [nucleotide binding]; other site 378753004843 domain interface; other site 378753004844 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 378753004845 16S/18S rRNA binding site [nucleotide binding]; other site 378753004846 S13e-L30e interaction site [polypeptide binding]; other site 378753004847 25S rRNA binding site [nucleotide binding]; other site 378753004848 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 378753004849 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 378753004850 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378753004851 active site 378753004852 catalytic tetrad [active] 378753004853 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 378753004854 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 378753004855 active site 378753004856 Riboflavin kinase; Region: Flavokinase; pfam01687 378753004857 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 378753004858 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 378753004859 RNA binding site [nucleotide binding]; other site 378753004860 active site 378753004861 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 378753004862 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 378753004863 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 378753004864 translation initiation factor IF-2; Region: IF-2; TIGR00487 378753004865 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 378753004866 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 378753004867 G1 box; other site 378753004868 putative GEF interaction site [polypeptide binding]; other site 378753004869 GTP/Mg2+ binding site [chemical binding]; other site 378753004870 Switch I region; other site 378753004871 G2 box; other site 378753004872 G3 box; other site 378753004873 Switch II region; other site 378753004874 G4 box; other site 378753004875 G5 box; other site 378753004876 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 378753004877 Translation-initiation factor 2; Region: IF-2; pfam11987 378753004878 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 378753004879 Protein of unknown function (DUF448); Region: DUF448; pfam04296 378753004880 putative RNA binding cleft [nucleotide binding]; other site 378753004881 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 378753004882 NusA N-terminal domain; Region: NusA_N; pfam08529 378753004883 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 378753004884 RNA binding site [nucleotide binding]; other site 378753004885 homodimer interface [polypeptide binding]; other site 378753004886 NusA-like KH domain; Region: KH_5; pfam13184 378753004887 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 378753004888 G-X-X-G motif; other site 378753004889 ribosome maturation protein RimP; Reviewed; Region: PRK00092 378753004890 Sm and related proteins; Region: Sm_like; cl00259 378753004891 Sm and related proteins; Region: Sm_like; cl00259 378753004892 heptamer interface [polypeptide binding]; other site 378753004893 Sm1 motif; other site 378753004894 hexamer interface [polypeptide binding]; other site 378753004895 RNA binding site [nucleotide binding]; other site 378753004896 Sm2 motif; other site 378753004897 hypothetical protein; Provisional; Region: PRK10621 378753004898 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 378753004899 prolyl-tRNA synthetase; Provisional; Region: PRK09194 378753004900 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 378753004901 dimer interface [polypeptide binding]; other site 378753004902 motif 1; other site 378753004903 active site 378753004904 motif 2; other site 378753004905 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 378753004906 putative deacylase active site [active] 378753004907 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378753004908 active site 378753004909 motif 3; other site 378753004910 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 378753004911 anticodon binding site; other site 378753004912 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 378753004913 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 378753004914 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 378753004915 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 378753004916 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 378753004917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753004918 conserved gate region; other site 378753004919 ABC-ATPase subunit interface; other site 378753004920 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 378753004921 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 378753004922 Walker A/P-loop; other site 378753004923 ATP binding site [chemical binding]; other site 378753004924 Q-loop/lid; other site 378753004925 ABC transporter signature motif; other site 378753004926 Walker B; other site 378753004927 D-loop; other site 378753004928 H-loop/switch region; other site 378753004929 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 378753004930 NLPA lipoprotein; Region: Lipoprotein_9; cl17547 378753004931 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 378753004932 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 378753004933 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 378753004934 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 378753004935 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 378753004936 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 378753004937 Na binding site [ion binding]; other site 378753004938 Protein of unknown function, DUF485; Region: DUF485; pfam04341 378753004939 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 378753004940 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 378753004941 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 378753004942 ribosome recycling factor; Reviewed; Region: frr; PRK00083 378753004943 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 378753004944 hinge region; other site 378753004945 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 378753004946 putative nucleotide binding site [chemical binding]; other site 378753004947 uridine monophosphate binding site [chemical binding]; other site 378753004948 homohexameric interface [polypeptide binding]; other site 378753004949 elongation factor Ts; Provisional; Region: tsf; PRK09377 378753004950 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 378753004951 Elongation factor TS; Region: EF_TS; pfam00889 378753004952 Elongation factor TS; Region: EF_TS; pfam00889 378753004953 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 378753004954 rRNA interaction site [nucleotide binding]; other site 378753004955 S8 interaction site; other site 378753004956 putative laminin-1 binding site; other site 378753004957 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 378753004958 Peptidase family M23; Region: Peptidase_M23; pfam01551 378753004959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753004960 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 378753004961 putative ADP-binding pocket [chemical binding]; other site 378753004962 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 378753004963 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 378753004964 Walker A/P-loop; other site 378753004965 ATP binding site [chemical binding]; other site 378753004966 Q-loop/lid; other site 378753004967 ABC transporter signature motif; other site 378753004968 Walker B; other site 378753004969 D-loop; other site 378753004970 H-loop/switch region; other site 378753004971 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378753004972 FtsX-like permease family; Region: FtsX; pfam02687 378753004973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378753004974 Histidine kinase; Region: HisKA_3; pfam07730 378753004975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753004976 ATP binding site [chemical binding]; other site 378753004977 G-X-G motif; other site 378753004978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753004979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753004980 active site 378753004981 phosphorylation site [posttranslational modification] 378753004982 intermolecular recognition site; other site 378753004983 dimerization interface [polypeptide binding]; other site 378753004984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753004985 DNA binding residues [nucleotide binding] 378753004986 dimerization interface [polypeptide binding]; other site 378753004987 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 378753004988 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753004989 catalytic residue [active] 378753004990 Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542 378753004991 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378753004992 Protein of unknown function (DUF998); Region: DUF998; pfam06197 378753004993 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 378753004994 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 378753004995 metal binding site [ion binding]; metal-binding site 378753004996 DNA primase, catalytic core; Region: dnaG; TIGR01391 378753004997 CHC2 zinc finger; Region: zf-CHC2; pfam01807 378753004998 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 378753004999 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 378753005000 active site 378753005001 metal binding site [ion binding]; metal-binding site 378753005002 interdomain interaction site; other site 378753005003 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 378753005004 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 378753005005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378753005006 Zn2+ binding site [ion binding]; other site 378753005007 Mg2+ binding site [ion binding]; other site 378753005008 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 378753005009 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 378753005010 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 378753005011 FMN binding site [chemical binding]; other site 378753005012 active site 378753005013 catalytic residues [active] 378753005014 substrate binding site [chemical binding]; other site 378753005015 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 378753005016 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 378753005017 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 378753005018 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 378753005019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753005020 putative substrate translocation pore; other site 378753005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753005022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753005023 Coenzyme A binding pocket [chemical binding]; other site 378753005024 glycyl-tRNA synthetase; Provisional; Region: PRK04173 378753005025 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378753005026 motif 1; other site 378753005027 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 378753005028 active site 378753005029 motif 2; other site 378753005030 motif 3; other site 378753005031 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 378753005032 anticodon binding site; other site 378753005033 acyl-coenzyme A oxidase; Region: PLN02526 378753005034 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753005035 active site 378753005036 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378753005037 MarR family; Region: MarR; pfam01047 378753005038 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 378753005039 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 378753005040 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 378753005041 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 378753005042 tetrameric interface [polypeptide binding]; other site 378753005043 NAD binding site [chemical binding]; other site 378753005044 catalytic residues [active] 378753005045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 378753005046 RNA binding surface [nucleotide binding]; other site 378753005047 putative hydrolase; Provisional; Region: PRK11460 378753005048 Predicted esterase [General function prediction only]; Region: COG0400 378753005049 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 378753005050 active site 378753005051 catalytic triad [active] 378753005052 oxyanion hole [active] 378753005053 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 378753005054 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 378753005055 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 378753005056 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 378753005057 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 378753005058 homodimer interface [polypeptide binding]; other site 378753005059 substrate-cofactor binding pocket; other site 378753005060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753005061 catalytic residue [active] 378753005062 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 378753005063 CAAX protease self-immunity; Region: Abi; pfam02517 378753005064 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378753005065 Histidine kinase; Region: HisKA_3; pfam07730 378753005066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753005067 ATP binding site [chemical binding]; other site 378753005068 Mg2+ binding site [ion binding]; other site 378753005069 G-X-G motif; other site 378753005070 Response regulator receiver domain; Region: Response_reg; pfam00072 378753005071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753005072 active site 378753005073 phosphorylation site [posttranslational modification] 378753005074 intermolecular recognition site; other site 378753005075 dimerization interface [polypeptide binding]; other site 378753005076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753005077 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753005078 DNA binding residues [nucleotide binding] 378753005079 dimerization interface [polypeptide binding]; other site 378753005080 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 378753005081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753005082 Walker A/P-loop; other site 378753005083 ATP binding site [chemical binding]; other site 378753005084 Q-loop/lid; other site 378753005085 ABC transporter signature motif; other site 378753005086 Walker B; other site 378753005087 D-loop; other site 378753005088 H-loop/switch region; other site 378753005089 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 378753005090 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 378753005091 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 378753005092 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 378753005093 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 378753005094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753005095 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 378753005096 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 378753005097 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 378753005098 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 378753005099 active site 378753005100 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 378753005101 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 378753005102 nucleotide binding pocket [chemical binding]; other site 378753005103 K-X-D-G motif; other site 378753005104 catalytic site [active] 378753005105 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 378753005106 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 378753005107 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 378753005108 Dimer interface [polypeptide binding]; other site 378753005109 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 378753005110 active site 2 [active] 378753005111 active site 1 [active] 378753005112 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 378753005113 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753005114 NAD(P) binding site [chemical binding]; other site 378753005115 active site 378753005116 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 378753005117 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 378753005118 dimer interface [polypeptide binding]; other site 378753005119 active site 378753005120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753005121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753005122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753005123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753005124 active site 378753005125 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 378753005126 Protein phosphatase 2C; Region: PP2C; pfam00481 378753005127 active site 378753005128 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 378753005129 cyclase homology domain; Region: CHD; cd07302 378753005130 nucleotidyl binding site; other site 378753005131 metal binding site [ion binding]; metal-binding site 378753005132 dimer interface [polypeptide binding]; other site 378753005133 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 378753005134 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 378753005135 YCII-related domain; Region: YCII; cl00999 378753005136 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 378753005137 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 378753005138 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 378753005139 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 378753005140 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 378753005141 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 378753005142 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 378753005143 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 378753005144 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753005145 NAD(P) binding site [chemical binding]; other site 378753005146 catalytic residues [active] 378753005147 Protein of unknown function (DUF779); Region: DUF779; pfam05610 378753005148 Integrase core domain; Region: rve; pfam00665 378753005149 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 378753005150 SnoaL-like domain; Region: SnoaL_2; pfam12680 378753005151 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 378753005152 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 378753005153 NADP binding site [chemical binding]; other site 378753005154 Homeodomain-like domain; Region: HTH_23; cl17451 378753005155 Winged helix-turn helix; Region: HTH_29; pfam13551 378753005156 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 378753005157 Maf-like protein; Region: Maf; pfam02545 378753005158 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 378753005159 active site 378753005160 dimer interface [polypeptide binding]; other site 378753005161 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 378753005162 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378753005163 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 378753005164 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 378753005165 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 378753005166 carboxyltransferase (CT) interaction site; other site 378753005167 biotinylation site [posttranslational modification]; other site 378753005168 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753005169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753005170 putative substrate translocation pore; other site 378753005171 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 378753005172 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753005173 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753005174 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378753005175 purine nucleoside phosphorylase; Provisional; Region: PRK08202 378753005176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753005177 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 378753005178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753005179 NAD(P) binding site [chemical binding]; other site 378753005180 active site 378753005181 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 378753005182 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 378753005183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753005184 ATP binding site [chemical binding]; other site 378753005185 putative Mg++ binding site [ion binding]; other site 378753005186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753005187 nucleotide binding region [chemical binding]; other site 378753005188 ATP-binding site [chemical binding]; other site 378753005189 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 378753005190 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 378753005191 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 378753005192 active site 378753005193 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 378753005194 putative active site [active] 378753005195 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 378753005196 active site 378753005197 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 378753005198 active site 378753005199 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 378753005200 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 378753005201 active site 378753005202 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 378753005203 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753005204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753005205 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753005206 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753005207 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 378753005208 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 378753005209 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753005210 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753005211 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753005212 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 378753005213 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 378753005214 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 378753005215 putative active site [active] 378753005216 catalytic residue [active] 378753005217 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 378753005218 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 378753005219 5S rRNA interface [nucleotide binding]; other site 378753005220 CTC domain interface [polypeptide binding]; other site 378753005221 L16 interface [polypeptide binding]; other site 378753005222 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 378753005223 Bacterial sugar transferase; Region: Bac_transf; pfam02397 378753005224 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 378753005225 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 378753005226 active site 378753005227 LGFP repeat; Region: LGFP; pfam08310 378753005228 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 378753005229 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 378753005230 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753005231 active site 378753005232 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 378753005233 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 378753005234 Substrate binding site; other site 378753005235 Mg++ binding site; other site 378753005236 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 378753005237 active site 378753005238 substrate binding site [chemical binding]; other site 378753005239 CoA binding site [chemical binding]; other site 378753005240 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 378753005241 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 378753005242 ABC transporter; Region: ABC_tran_2; pfam12848 378753005243 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 378753005244 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 378753005245 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 378753005246 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 378753005247 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 378753005248 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753005249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753005250 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 378753005251 amino acid transporter; Region: 2A0306; TIGR00909 378753005252 RNB domain; Region: RNB; pfam00773 378753005253 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 378753005254 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 378753005255 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 378753005256 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 378753005257 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 378753005258 active site 378753005259 MoxR-like ATPases [General function prediction only]; Region: COG0714 378753005260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753005261 Walker A motif; other site 378753005262 ATP binding site [chemical binding]; other site 378753005263 Walker B motif; other site 378753005264 arginine finger; other site 378753005265 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 378753005266 Protein of unknown function DUF58; Region: DUF58; pfam01882 378753005267 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 378753005268 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 378753005269 Predicted methyltransferases [General function prediction only]; Region: COG0313 378753005270 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 378753005271 putative SAM binding site [chemical binding]; other site 378753005272 putative homodimer interface [polypeptide binding]; other site 378753005273 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 378753005274 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 378753005275 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 378753005276 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 378753005277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 378753005278 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 378753005279 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 378753005280 Transcription factor WhiB; Region: Whib; pfam02467 378753005281 TIGR03089 family protein; Region: TIGR03089 378753005282 Predicted membrane protein [Function unknown]; Region: COG2246 378753005283 GtrA-like protein; Region: GtrA; pfam04138 378753005284 phosphoribosylaminoimidazole carboxylase; Region: PLN02948 378753005285 ATP-grasp domain; Region: ATP-grasp; pfam02222 378753005286 AIR carboxylase; Region: AIRC; pfam00731 378753005287 Transcriptional regulator [Transcription]; Region: LytR; COG1316 378753005288 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 378753005289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 378753005290 short chain dehydrogenase; Provisional; Region: PRK06101 378753005291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753005292 NAD(P) binding site [chemical binding]; other site 378753005293 active site 378753005294 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 378753005295 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 378753005296 putative active site [active] 378753005297 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 378753005298 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 378753005299 active site clefts [active] 378753005300 zinc binding site [ion binding]; other site 378753005301 dimer interface [polypeptide binding]; other site 378753005302 fumarate hydratase; Reviewed; Region: fumC; PRK00485 378753005303 Class II fumarases; Region: Fumarase_classII; cd01362 378753005304 active site 378753005305 tetramer interface [polypeptide binding]; other site 378753005306 pyruvate dehydrogenase; Provisional; Region: PRK06546 378753005307 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 378753005308 PYR/PP interface [polypeptide binding]; other site 378753005309 dimer interface [polypeptide binding]; other site 378753005310 tetramer interface [polypeptide binding]; other site 378753005311 TPP binding site [chemical binding]; other site 378753005312 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378753005313 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 378753005314 TPP-binding site [chemical binding]; other site 378753005315 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 378753005316 nudix motif; other site 378753005317 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 378753005318 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 378753005319 putative active site [active] 378753005320 PhoH-like protein; Region: PhoH; pfam02562 378753005321 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 378753005322 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 378753005323 catalytic residue [active] 378753005324 putative FPP diphosphate binding site; other site 378753005325 putative FPP binding hydrophobic cleft; other site 378753005326 dimer interface [polypeptide binding]; other site 378753005327 putative IPP diphosphate binding site; other site 378753005328 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 378753005329 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 378753005330 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 378753005331 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 378753005332 catalytic residues [active] 378753005333 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 378753005334 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 378753005335 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 378753005336 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 378753005337 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 378753005338 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 378753005339 threonine dehydratase; Provisional; Region: PRK08198 378753005340 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 378753005341 tetramer interface [polypeptide binding]; other site 378753005342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753005343 catalytic residue [active] 378753005344 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 378753005345 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 378753005346 Domain of unknown function DUF20; Region: UPF0118; pfam01594 378753005347 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 378753005348 FMN binding site [chemical binding]; other site 378753005349 dimer interface [polypeptide binding]; other site 378753005350 Bax inhibitor 1 like; Region: BaxI_1; cl17691 378753005351 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 378753005352 XdhC Rossmann domain; Region: XdhC_C; pfam13478 378753005353 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753005354 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 378753005355 active site 378753005356 catalytic residues [active] 378753005357 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 378753005358 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 378753005359 Protein of unknown function (DUF501); Region: DUF501; pfam04417 378753005360 Septum formation initiator; Region: DivIC; cl17659 378753005361 enolase; Provisional; Region: eno; PRK00077 378753005362 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 378753005363 dimer interface [polypeptide binding]; other site 378753005364 metal binding site [ion binding]; metal-binding site 378753005365 substrate binding pocket [chemical binding]; other site 378753005366 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 378753005367 homodimer interface [polypeptide binding]; other site 378753005368 metal binding site [ion binding]; metal-binding site 378753005369 adenosine deaminase; Provisional; Region: PRK09358 378753005370 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 378753005371 active site 378753005372 Mid-1-related chloride channel (MCLC); Region: MCLC; pfam05934 378753005373 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 378753005374 active site 378753005375 catalytic motif [active] 378753005376 Zn binding site [ion binding]; other site 378753005377 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 378753005378 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 378753005379 ligand binding site [chemical binding]; other site 378753005380 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 378753005381 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 378753005382 metal binding site [ion binding]; metal-binding site 378753005383 putative dimer interface [polypeptide binding]; other site 378753005384 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 378753005385 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 378753005386 Substrate binding site; other site 378753005387 Cupin domain; Region: Cupin_2; cl17218 378753005388 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 378753005389 putative Iron-sulfur protein interface [polypeptide binding]; other site 378753005390 putative proximal heme binding site [chemical binding]; other site 378753005391 putative SdhD-like interface [polypeptide binding]; other site 378753005392 putative distal heme binding site [chemical binding]; other site 378753005393 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 378753005394 putative Iron-sulfur protein interface [polypeptide binding]; other site 378753005395 putative proximal heme binding site [chemical binding]; other site 378753005396 putative SdhC-like subunit interface [polypeptide binding]; other site 378753005397 putative distal heme binding site [chemical binding]; other site 378753005398 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 378753005399 L-aspartate oxidase; Provisional; Region: PRK06175 378753005400 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 378753005401 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 378753005402 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 378753005403 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 378753005404 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 378753005405 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 378753005406 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 378753005407 active site 378753005408 HIGH motif; other site 378753005409 dimer interface [polypeptide binding]; other site 378753005410 KMSKS motif; other site 378753005411 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 378753005412 putative active site [active] 378753005413 putative catalytic site [active] 378753005414 putative DNA binding site [nucleotide binding]; other site 378753005415 putative phosphate binding site [ion binding]; other site 378753005416 metal binding site A [ion binding]; metal-binding site 378753005417 putative AP binding site [nucleotide binding]; other site 378753005418 putative metal binding site B [ion binding]; other site 378753005419 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 378753005420 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 378753005421 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 378753005422 homodimer interface [polypeptide binding]; other site 378753005423 NADP binding site [chemical binding]; other site 378753005424 substrate binding site [chemical binding]; other site 378753005425 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 378753005426 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 378753005427 dimer interface [polypeptide binding]; other site 378753005428 active site 378753005429 glycine-pyridoxal phosphate binding site [chemical binding]; other site 378753005430 folate binding site [chemical binding]; other site 378753005431 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 378753005432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753005433 motif II; other site 378753005434 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 378753005435 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 378753005436 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 378753005437 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 378753005438 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 378753005439 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 378753005440 trimer interface [polypeptide binding]; other site 378753005441 putative metal binding site [ion binding]; other site 378753005442 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 378753005443 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 378753005444 purine monophosphate binding site [chemical binding]; other site 378753005445 dimer interface [polypeptide binding]; other site 378753005446 putative catalytic residues [active] 378753005447 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 378753005448 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 378753005449 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 378753005450 active site 378753005451 substrate binding site [chemical binding]; other site 378753005452 cosubstrate binding site; other site 378753005453 catalytic site [active] 378753005454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753005455 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 378753005456 choline dehydrogenase; Validated; Region: PRK02106 378753005457 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 378753005458 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 378753005459 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753005460 NAD(P) binding site [chemical binding]; other site 378753005461 catalytic residues [active] 378753005462 BCCT family transporter; Region: BCCT; cl00569 378753005463 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 378753005464 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 378753005465 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 378753005466 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753005467 ATP binding site [chemical binding]; other site 378753005468 putative Mg++ binding site [ion binding]; other site 378753005469 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753005470 nucleotide binding region [chemical binding]; other site 378753005471 ATP-binding site [chemical binding]; other site 378753005472 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 378753005473 diiron binding motif [ion binding]; other site 378753005474 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 378753005475 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 378753005476 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 378753005477 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 378753005478 putative active site [active] 378753005479 putative substrate binding site [chemical binding]; other site 378753005480 putative cosubstrate binding site; other site 378753005481 catalytic site [active] 378753005482 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 378753005483 CoA binding domain; Region: CoA_binding; smart00881 378753005484 CoA-ligase; Region: Ligase_CoA; pfam00549 378753005485 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 378753005486 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 378753005487 CoA-ligase; Region: Ligase_CoA; pfam00549 378753005488 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 378753005489 Part of AAA domain; Region: AAA_19; pfam13245 378753005490 Family description; Region: UvrD_C_2; pfam13538 378753005491 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 378753005492 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 378753005493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 378753005494 NlpC/P60 family; Region: NLPC_P60; pfam00877 378753005495 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 378753005496 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 378753005497 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 378753005498 phosphoserine aminotransferase; Provisional; Region: PRK03080 378753005499 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753005500 catalytic residue [active] 378753005501 H+ Antiporter protein; Region: 2A0121; TIGR00900 378753005502 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753005503 putative substrate translocation pore; other site 378753005504 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 378753005505 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 378753005506 DNA-binding site [nucleotide binding]; DNA binding site 378753005507 RNA-binding motif; other site 378753005508 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378753005509 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753005510 active site 378753005511 phosphorylation site [posttranslational modification] 378753005512 intermolecular recognition site; other site 378753005513 dimerization interface [polypeptide binding]; other site 378753005514 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 378753005515 DNA binding site [nucleotide binding] 378753005516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378753005517 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 378753005518 dimerization interface [polypeptide binding]; other site 378753005519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 378753005520 dimer interface [polypeptide binding]; other site 378753005521 phosphorylation site [posttranslational modification] 378753005522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753005523 ATP binding site [chemical binding]; other site 378753005524 Mg2+ binding site [ion binding]; other site 378753005525 G-X-G motif; other site 378753005526 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 378753005527 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 378753005528 RNA/DNA hybrid binding site [nucleotide binding]; other site 378753005529 active site 378753005530 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 378753005531 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 378753005532 ring oligomerisation interface [polypeptide binding]; other site 378753005533 ATP/Mg binding site [chemical binding]; other site 378753005534 stacking interactions; other site 378753005535 hinge regions; other site 378753005536 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 378753005537 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 378753005538 ligand binding site [chemical binding]; other site 378753005539 active site 378753005540 UGI interface [polypeptide binding]; other site 378753005541 catalytic site [active] 378753005542 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 378753005543 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 378753005544 FAD binding pocket [chemical binding]; other site 378753005545 FAD binding motif [chemical binding]; other site 378753005546 phosphate binding motif [ion binding]; other site 378753005547 NAD binding pocket [chemical binding]; other site 378753005548 Uncharacterized conserved protein [Function unknown]; Region: COG2966 378753005549 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 378753005550 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 378753005551 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 378753005552 FemAB family; Region: FemAB; pfam02388 378753005553 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 378753005554 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 378753005555 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 378753005556 active site 378753005557 FMN binding site [chemical binding]; other site 378753005558 substrate binding site [chemical binding]; other site 378753005559 3Fe-4S cluster binding site [ion binding]; other site 378753005560 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 378753005561 dimerization domain swap beta strand [polypeptide binding]; other site 378753005562 regulatory protein interface [polypeptide binding]; other site 378753005563 active site 378753005564 regulatory phosphorylation site [posttranslational modification]; other site 378753005565 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 378753005566 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 378753005567 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 378753005568 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 378753005569 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 378753005570 active site 378753005571 phosphorylation site [posttranslational modification] 378753005572 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 378753005573 active site 378753005574 P-loop; other site 378753005575 phosphorylation site [posttranslational modification] 378753005576 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 378753005577 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 378753005578 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 378753005579 putative substrate binding site [chemical binding]; other site 378753005580 putative ATP binding site [chemical binding]; other site 378753005581 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 378753005582 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 378753005583 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 378753005584 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378753005585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 378753005586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753005587 Walker A/P-loop; other site 378753005588 ATP binding site [chemical binding]; other site 378753005589 Q-loop/lid; other site 378753005590 ABC transporter signature motif; other site 378753005591 Walker B; other site 378753005592 D-loop; other site 378753005593 H-loop/switch region; other site 378753005594 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 378753005595 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 378753005596 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 378753005597 Walker A/P-loop; other site 378753005598 ATP binding site [chemical binding]; other site 378753005599 Q-loop/lid; other site 378753005600 ABC transporter signature motif; other site 378753005601 Walker B; other site 378753005602 D-loop; other site 378753005603 H-loop/switch region; other site 378753005604 TIGR03085 family protein; Region: TIGR03085 378753005605 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 378753005606 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 378753005607 catalytic residues [active] 378753005608 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 378753005609 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 378753005610 active site 378753005611 homotetramer interface [polypeptide binding]; other site 378753005612 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 378753005613 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 378753005614 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 378753005615 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 378753005616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753005617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753005618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753005619 fatty acyl-CoA reductase; Region: PLN02996 378753005620 NAD(P) binding site [chemical binding]; other site 378753005621 active site 378753005622 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 378753005623 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 378753005624 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 378753005625 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 378753005626 classical (c) SDRs; Region: SDR_c; cd05233 378753005627 NAD(P) binding site [chemical binding]; other site 378753005628 active site 378753005629 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 378753005630 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 378753005631 putative acyl-acceptor binding pocket; other site 378753005632 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 378753005633 FAD binding domain; Region: FAD_binding_4; pfam01565 378753005634 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 378753005635 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753005636 acyl-activating enzyme (AAE) consensus motif; other site 378753005637 AMP binding site [chemical binding]; other site 378753005638 active site 378753005639 CoA binding site [chemical binding]; other site 378753005640 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 378753005641 glycogen branching enzyme; Provisional; Region: PRK05402 378753005642 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 378753005643 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 378753005644 active site 378753005645 catalytic site [active] 378753005646 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 378753005647 trehalose synthase; Region: treS_nterm; TIGR02456 378753005648 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 378753005649 active site 378753005650 catalytic site [active] 378753005651 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 378753005652 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 378753005653 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 378753005654 active site 378753005655 homodimer interface [polypeptide binding]; other site 378753005656 catalytic site [active] 378753005657 acceptor binding site [chemical binding]; other site 378753005658 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 378753005659 putative homodimer interface [polypeptide binding]; other site 378753005660 putative active site pocket [active] 378753005661 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 378753005662 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 378753005663 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 378753005664 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 378753005665 active site 378753005666 catalytic site [active] 378753005667 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 378753005668 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 378753005669 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 378753005670 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 378753005671 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 378753005672 active site 378753005673 HIGH motif; other site 378753005674 nucleotide binding site [chemical binding]; other site 378753005675 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 378753005676 KMSKS motif; other site 378753005677 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 378753005678 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 378753005679 homotrimer interaction site [polypeptide binding]; other site 378753005680 zinc binding site [ion binding]; other site 378753005681 CDP-binding sites; other site 378753005682 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 378753005683 substrate binding site; other site 378753005684 dimer interface; other site 378753005685 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 378753005686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 378753005687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753005688 active site 378753005689 phosphorylation site [posttranslational modification] 378753005690 intermolecular recognition site; other site 378753005691 dimerization interface [polypeptide binding]; other site 378753005692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 378753005693 DNA binding site [nucleotide binding] 378753005694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 378753005695 dimer interface [polypeptide binding]; other site 378753005696 phosphorylation site [posttranslational modification] 378753005697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753005698 ATP binding site [chemical binding]; other site 378753005699 Mg2+ binding site [ion binding]; other site 378753005700 G-X-G motif; other site 378753005701 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 378753005702 PhoU domain; Region: PhoU; pfam01895 378753005703 PhoU domain; Region: PhoU; pfam01895 378753005704 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378753005705 catalytic core [active] 378753005706 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 378753005707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 378753005708 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 378753005709 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 378753005710 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753005711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753005712 catalytic residue [active] 378753005713 thymidylate kinase; Region: DTMP_kinase; TIGR00041 378753005714 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 378753005715 TMP-binding site; other site 378753005716 ATP-binding site [chemical binding]; other site 378753005717 DNA polymerase III subunit delta'; Validated; Region: PRK07940 378753005718 DNA polymerase III subunit delta'; Validated; Region: PRK08485 378753005719 TAP-like protein; Region: Abhydrolase_4; pfam08386 378753005720 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 378753005721 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 378753005722 Soluble P-type ATPase [General function prediction only]; Region: COG4087 378753005723 Protein of unknown function (DUF466); Region: DUF466; cl01082 378753005724 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 378753005725 Carbon starvation protein CstA; Region: CstA; pfam02554 378753005726 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 378753005727 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 378753005728 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 378753005729 NAD(P) binding site [chemical binding]; other site 378753005730 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 378753005731 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 378753005732 active site 378753005733 substrate binding site [chemical binding]; other site 378753005734 metal binding site [ion binding]; metal-binding site 378753005735 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 378753005736 intersubunit interface [polypeptide binding]; other site 378753005737 active site 378753005738 catalytic residue [active] 378753005739 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 378753005740 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 378753005741 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 378753005742 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 378753005743 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 378753005744 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 378753005745 Nucleoside recognition; Region: Gate; pfam07670 378753005746 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 378753005747 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 378753005748 MarR family; Region: MarR_2; cl17246 378753005749 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 378753005750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 378753005751 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 378753005752 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 378753005753 active site 378753005754 catalytic triad [active] 378753005755 LGFP repeat; Region: LGFP; pfam08310 378753005756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753005757 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 378753005758 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 378753005759 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 378753005760 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 378753005761 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 378753005762 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753005763 ATP binding site [chemical binding]; other site 378753005764 putative Mg++ binding site [ion binding]; other site 378753005765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753005766 nucleotide binding region [chemical binding]; other site 378753005767 ATP-binding site [chemical binding]; other site 378753005768 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 378753005769 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 378753005770 hydrophobic ligand binding site; other site 378753005771 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 378753005772 glutaminase; Provisional; Region: PRK00971 378753005773 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 378753005774 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 378753005775 ligand binding site [chemical binding]; other site 378753005776 flexible hinge region; other site 378753005777 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 378753005778 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 378753005779 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 378753005780 Walker A/P-loop; other site 378753005781 ATP binding site [chemical binding]; other site 378753005782 Q-loop/lid; other site 378753005783 ABC transporter signature motif; other site 378753005784 Walker B; other site 378753005785 D-loop; other site 378753005786 H-loop/switch region; other site 378753005787 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 378753005788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753005789 dimer interface [polypeptide binding]; other site 378753005790 conserved gate region; other site 378753005791 putative PBP binding loops; other site 378753005792 ABC-ATPase subunit interface; other site 378753005793 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 378753005794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753005795 dimer interface [polypeptide binding]; other site 378753005796 conserved gate region; other site 378753005797 putative PBP binding loops; other site 378753005798 ABC-ATPase subunit interface; other site 378753005799 PBP superfamily domain; Region: PBP_like_2; cl17296 378753005800 Predicted membrane protein [Function unknown]; Region: COG4129 378753005801 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 378753005802 DNA repair protein RadA; Provisional; Region: PRK11823 378753005803 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 378753005804 Walker A motif; other site 378753005805 ATP binding site [chemical binding]; other site 378753005806 Walker B motif; other site 378753005807 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 378753005808 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 378753005809 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 378753005810 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 378753005811 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 378753005812 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 378753005813 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 378753005814 endonuclease III; Region: ENDO3c; smart00478 378753005815 minor groove reading motif; other site 378753005816 helix-hairpin-helix signature motif; other site 378753005817 substrate binding pocket [chemical binding]; other site 378753005818 active site 378753005819 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 378753005820 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753005821 Coenzyme A binding pocket [chemical binding]; other site 378753005822 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 378753005823 Clp amino terminal domain; Region: Clp_N; pfam02861 378753005824 Clp amino terminal domain; Region: Clp_N; pfam02861 378753005825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753005826 Walker A motif; other site 378753005827 ATP binding site [chemical binding]; other site 378753005828 Walker B motif; other site 378753005829 arginine finger; other site 378753005830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753005831 Walker A motif; other site 378753005832 ATP binding site [chemical binding]; other site 378753005833 Walker B motif; other site 378753005834 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 378753005835 Lsr2; Region: Lsr2; pfam11774 378753005836 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 378753005837 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 378753005838 putative anticodon binding site; other site 378753005839 dimer interface [polypeptide binding]; other site 378753005840 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378753005841 motif 1; other site 378753005842 dimer interface [polypeptide binding]; other site 378753005843 active site 378753005844 motif 2; other site 378753005845 motif 3; other site 378753005846 pantoate--beta-alanine ligase; Region: panC; TIGR00018 378753005847 Pantoate-beta-alanine ligase; Region: PanC; cd00560 378753005848 active site 378753005849 ATP-binding site [chemical binding]; other site 378753005850 pantoate-binding site; other site 378753005851 HXXH motif; other site 378753005852 Rossmann-like domain; Region: Rossmann-like; pfam10727 378753005853 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 378753005854 Bacterial PH domain; Region: DUF304; pfam03703 378753005855 Bacterial PH domain; Region: DUF304; pfam03703 378753005856 Bacterial PH domain; Region: DUF304; pfam03703 378753005857 Bacterial PH domain; Region: DUF304; cl01348 378753005858 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 378753005859 catalytic center binding site [active] 378753005860 ATP binding site [chemical binding]; other site 378753005861 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 378753005862 homooctamer interface [polypeptide binding]; other site 378753005863 active site 378753005864 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 378753005865 dihydropteroate synthase; Region: DHPS; TIGR01496 378753005866 substrate binding pocket [chemical binding]; other site 378753005867 inhibitor binding site; inhibition site 378753005868 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 378753005869 homodecamer interface [polypeptide binding]; other site 378753005870 GTP cyclohydrolase I; Provisional; Region: PLN03044 378753005871 active site 378753005872 putative catalytic site residues [active] 378753005873 zinc binding site [ion binding]; other site 378753005874 GTP-CH-I/GFRP interaction surface; other site 378753005875 FtsH Extracellular; Region: FtsH_ext; pfam06480 378753005876 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 378753005877 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 378753005878 Walker A motif; other site 378753005879 ATP binding site [chemical binding]; other site 378753005880 Walker B motif; other site 378753005881 arginine finger; other site 378753005882 Peptidase family M41; Region: Peptidase_M41; pfam01434 378753005883 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 378753005884 active site 378753005885 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 378753005886 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 378753005887 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 378753005888 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 378753005889 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 378753005890 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 378753005891 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 378753005892 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 378753005893 dimer interface [polypeptide binding]; other site 378753005894 substrate binding site [chemical binding]; other site 378753005895 metal binding sites [ion binding]; metal-binding site 378753005896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753005897 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 378753005898 active site 378753005899 motif I; other site 378753005900 motif II; other site 378753005901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753005902 seryl-tRNA synthetase; Provisional; Region: PRK05431 378753005903 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 378753005904 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 378753005905 dimer interface [polypeptide binding]; other site 378753005906 active site 378753005907 motif 1; other site 378753005908 motif 2; other site 378753005909 motif 3; other site 378753005910 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 378753005911 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 378753005912 fructuronate transporter; Provisional; Region: PRK10034; cl15264 378753005913 prephenate dehydratase; Provisional; Region: PRK11898 378753005914 Prephenate dehydratase; Region: PDT; pfam00800 378753005915 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 378753005916 putative L-Phe binding site [chemical binding]; other site 378753005917 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 378753005918 active site residue [active] 378753005919 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 378753005920 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378753005921 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 378753005922 active site 378753005923 thiamine pyrophosphate protein; Validated; Region: PRK08199 378753005924 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378753005925 PYR/PP interface [polypeptide binding]; other site 378753005926 dimer interface [polypeptide binding]; other site 378753005927 TPP binding site [chemical binding]; other site 378753005928 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378753005929 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 378753005930 TPP-binding site [chemical binding]; other site 378753005931 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378753005932 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 378753005933 active site 378753005934 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753005935 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 378753005936 NAD(P) binding site [chemical binding]; other site 378753005937 catalytic residues [active] 378753005938 succinic semialdehyde dehydrogenase; Region: PLN02278 378753005939 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 378753005940 tetramerization interface [polypeptide binding]; other site 378753005941 NAD(P) binding site [chemical binding]; other site 378753005942 catalytic residues [active] 378753005943 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 378753005944 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 378753005945 inhibitor-cofactor binding pocket; inhibition site 378753005946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753005947 catalytic residue [active] 378753005948 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 378753005949 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 378753005950 Amidase; Region: Amidase; cl11426 378753005951 phosphoglucomutase; Validated; Region: PRK07564 378753005952 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 378753005953 active site 378753005954 substrate binding site [chemical binding]; other site 378753005955 metal binding site [ion binding]; metal-binding site 378753005956 YrhK-like protein; Region: YrhK; pfam14145 378753005957 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 378753005958 Sulfatase; Region: Sulfatase; cl17466 378753005959 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 378753005960 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 378753005961 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 378753005962 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 378753005963 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 378753005964 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 378753005965 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378753005966 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 378753005967 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 378753005968 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753005969 substrate binding site [chemical binding]; other site 378753005970 oxyanion hole (OAH) forming residues; other site 378753005971 trimer interface [polypeptide binding]; other site 378753005972 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 378753005973 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 378753005974 gating phenylalanine in ion channel; other site 378753005975 Transcriptional regulator [Transcription]; Region: LysR; COG0583 378753005976 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 378753005977 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 378753005978 putative dimerization interface [polypeptide binding]; other site 378753005979 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 378753005980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 378753005981 Walker A/P-loop; other site 378753005982 ATP binding site [chemical binding]; other site 378753005983 Q-loop/lid; other site 378753005984 ABC transporter signature motif; other site 378753005985 Walker B; other site 378753005986 D-loop; other site 378753005987 H-loop/switch region; other site 378753005988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 378753005989 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 378753005990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 378753005991 Walker A/P-loop; other site 378753005992 ATP binding site [chemical binding]; other site 378753005993 Q-loop/lid; other site 378753005994 ABC transporter signature motif; other site 378753005995 Walker B; other site 378753005996 D-loop; other site 378753005997 H-loop/switch region; other site 378753005998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378753005999 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 378753006000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753006001 dimer interface [polypeptide binding]; other site 378753006002 conserved gate region; other site 378753006003 putative PBP binding loops; other site 378753006004 ABC-ATPase subunit interface; other site 378753006005 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 378753006006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753006007 dimer interface [polypeptide binding]; other site 378753006008 conserved gate region; other site 378753006009 putative PBP binding loops; other site 378753006010 ABC-ATPase subunit interface; other site 378753006011 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 378753006012 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 378753006013 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 378753006014 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 378753006015 active site 378753006016 catalytic site [active] 378753006017 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 378753006018 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 378753006019 active site 378753006020 motif I; other site 378753006021 motif II; other site 378753006022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 378753006023 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 378753006024 substrate binding site [chemical binding]; other site 378753006025 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 378753006026 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 378753006027 putative substrate binding site [chemical binding]; other site 378753006028 putative ATP binding site [chemical binding]; other site 378753006029 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 378753006030 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 378753006031 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 378753006032 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 378753006033 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 378753006034 active site 378753006035 metal binding site [ion binding]; metal-binding site 378753006036 CAAX protease self-immunity; Region: Abi; pfam02517 378753006037 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 378753006038 catalytic triad [active] 378753006039 putative OHCU decarboxylase; Provisional; Region: PRK13798 378753006040 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 378753006041 active site 378753006042 homotetramer interface [polypeptide binding]; other site 378753006043 urate oxidase; Region: urate_oxi; TIGR03383 378753006044 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 378753006045 active site 378753006046 xanthine permease; Region: pbuX; TIGR03173 378753006047 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 378753006048 Transcriptional regulator [Transcription]; Region: IclR; COG1414 378753006049 Bacterial transcriptional regulator; Region: IclR; pfam01614 378753006050 malate synthase A; Region: malate_syn_A; TIGR01344 378753006051 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 378753006052 active site 378753006053 hypothetical protein; Provisional; Region: PRK11171 378753006054 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 378753006055 Cupin domain; Region: Cupin_2; pfam07883 378753006056 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378753006057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753006058 Coenzyme A binding pocket [chemical binding]; other site 378753006059 Predicted membrane protein [Function unknown]; Region: COG2246 378753006060 GtrA-like protein; Region: GtrA; pfam04138 378753006061 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 378753006062 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 378753006063 putative NAD(P) binding site [chemical binding]; other site 378753006064 putative substrate binding site [chemical binding]; other site 378753006065 catalytic Zn binding site [ion binding]; other site 378753006066 structural Zn binding site [ion binding]; other site 378753006067 dimer interface [polypeptide binding]; other site 378753006068 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 378753006069 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 378753006070 allantoinase; Region: allantoinase; TIGR03178 378753006071 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 378753006072 active site 378753006073 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 378753006074 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378753006075 active site 378753006076 metal binding site [ion binding]; metal-binding site 378753006077 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 378753006078 active site 378753006079 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 378753006080 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378753006081 active site 378753006082 catalytic tetrad [active] 378753006083 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 378753006084 intracellular protease, PfpI family; Region: PfpI; TIGR01382 378753006085 proposed catalytic triad [active] 378753006086 conserved cys residue [active] 378753006087 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 378753006088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753006089 catalytic residue [active] 378753006090 HipA N-terminal domain; Region: Couple_hipA; pfam13657 378753006091 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 378753006092 HipA-like N-terminal domain; Region: HipA_N; pfam07805 378753006093 HipA-like C-terminal domain; Region: HipA_C; pfam07804 378753006094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 378753006095 sequence-specific DNA binding site [nucleotide binding]; other site 378753006096 salt bridge; other site 378753006097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006098 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753006099 putative substrate translocation pore; other site 378753006100 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 378753006101 putative hydrophobic ligand binding site [chemical binding]; other site 378753006102 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753006103 active site 378753006104 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753006105 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 378753006106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753006107 S-adenosylmethionine binding site [chemical binding]; other site 378753006108 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753006109 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753006110 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753006111 DNA-binding site [nucleotide binding]; DNA binding site 378753006112 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 378753006113 active site 378753006114 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 378753006115 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 378753006116 dimer interface [polypeptide binding]; other site 378753006117 putative functional site; other site 378753006118 putative MPT binding site; other site 378753006119 Protein of unknown function (DUF456); Region: DUF456; cl01069 378753006120 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 378753006121 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839 378753006122 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 378753006123 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 378753006124 catalytic core [active] 378753006125 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 378753006126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 378753006127 TPR repeat; Region: TPR_11; pfam13414 378753006128 binding surface 378753006129 TPR motif; other site 378753006130 Tetratricopeptide repeat; Region: TPR_12; pfam13424 378753006131 Tetratricopeptide repeat; Region: TPR_12; pfam13424 378753006132 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 378753006133 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 378753006134 active site 378753006135 catalytic tetrad [active] 378753006136 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 378753006137 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 378753006138 active site 378753006139 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 378753006140 putative active site [active] 378753006141 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 378753006142 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 378753006143 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753006144 putative DNA binding site [nucleotide binding]; other site 378753006145 putative Zn2+ binding site [ion binding]; other site 378753006146 AsnC family; Region: AsnC_trans_reg; pfam01037 378753006147 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 378753006148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753006149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753006150 homodimer interface [polypeptide binding]; other site 378753006151 catalytic residue [active] 378753006152 S-methylmethionine transporter; Provisional; Region: PRK11387 378753006153 LGFP repeat; Region: LGFP; pfam08310 378753006154 LGFP repeat; Region: LGFP; pfam08310 378753006155 N-acetyltransferase; Region: Acetyltransf_2; cl00949 378753006156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 378753006157 Uncharacterized conserved protein [Function unknown]; Region: COG4748 378753006158 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 378753006159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753006160 S-adenosylmethionine binding site [chemical binding]; other site 378753006161 glycerol-3-phosphate transporter; Region: glpT; TIGR00712 378753006162 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006163 putative substrate translocation pore; other site 378753006164 CAAX protease self-immunity; Region: Abi; pfam02517 378753006165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753006167 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 378753006168 ATP-binding site [chemical binding]; other site 378753006169 Gluconate-6-phosphate binding site [chemical binding]; other site 378753006170 Shikimate kinase; Region: SKI; pfam01202 378753006171 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 378753006172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753006173 S-adenosylmethionine binding site [chemical binding]; other site 378753006174 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 378753006175 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 378753006176 Domain of unknown function (DUF1839); Region: DUF1839; pfam08893 378753006177 hypothetical protein; Validated; Region: PRK07080 378753006178 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753006179 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 378753006180 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753006181 acyl carrier protein; Provisional; Region: PRK07081 378753006182 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 378753006183 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 378753006184 Putative esterase; Region: Esterase; pfam00756 378753006185 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 378753006186 putative glycosyl transferase; Provisional; Region: PRK10307 378753006187 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 378753006188 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 378753006189 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 378753006190 NADP-binding site; other site 378753006191 homotetramer interface [polypeptide binding]; other site 378753006192 substrate binding site [chemical binding]; other site 378753006193 homodimer interface [polypeptide binding]; other site 378753006194 active site 378753006195 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 378753006196 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 378753006197 NADP binding site [chemical binding]; other site 378753006198 active site 378753006199 putative substrate binding site [chemical binding]; other site 378753006200 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 378753006201 active site 378753006202 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 378753006203 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 378753006204 active site 378753006205 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 378753006206 ligand binding site [chemical binding]; other site 378753006207 putative catalytic site [active] 378753006208 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 378753006209 putative trimer interface [polypeptide binding]; other site 378753006210 putative active site [active] 378753006211 putative substrate binding site [chemical binding]; other site 378753006212 putative CoA binding site [chemical binding]; other site 378753006213 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 378753006214 This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821 378753006215 putative ADP-binding pocket [chemical binding]; other site 378753006216 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 378753006217 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 378753006218 ligand binding site [chemical binding]; other site 378753006219 NAD binding site [chemical binding]; other site 378753006220 tetramer interface [polypeptide binding]; other site 378753006221 catalytic site [active] 378753006222 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 378753006223 L-serine binding site [chemical binding]; other site 378753006224 ACT domain interface; other site 378753006225 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 378753006226 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 378753006227 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 378753006228 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 378753006229 transmembrane helices; other site 378753006230 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 378753006231 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 378753006232 dimerization interface [polypeptide binding]; other site 378753006233 DPS ferroxidase diiron center [ion binding]; other site 378753006234 ion pore; other site 378753006235 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 378753006236 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 378753006237 active site 378753006238 FMN binding site [chemical binding]; other site 378753006239 2,4-decadienoyl-CoA binding site; other site 378753006240 catalytic residue [active] 378753006241 4Fe-4S cluster binding site [ion binding]; other site 378753006242 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753006243 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 378753006244 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 378753006245 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378753006246 phosphopeptide binding site; other site 378753006247 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 378753006248 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 378753006249 phosphopeptide binding site; other site 378753006250 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 378753006251 active site 378753006252 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 378753006253 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 378753006254 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378753006255 Catalytic domain of Protein Kinases; Region: PKc; cd00180 378753006256 active site 378753006257 ATP binding site [chemical binding]; other site 378753006258 substrate binding site [chemical binding]; other site 378753006259 activation loop (A-loop); other site 378753006260 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 378753006261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 378753006262 active site 378753006263 ATP binding site [chemical binding]; other site 378753006264 substrate binding site [chemical binding]; other site 378753006265 activation loop (A-loop); other site 378753006266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 378753006267 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 378753006268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 378753006269 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 378753006270 Glutamine amidotransferase class-I; Region: GATase; pfam00117 378753006271 glutamine binding [chemical binding]; other site 378753006272 catalytic triad [active] 378753006273 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 378753006274 Uncharacterized conserved protein [Function unknown]; Region: COG2353 378753006275 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 378753006276 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 378753006277 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 378753006278 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 378753006279 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 378753006280 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378753006281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 378753006282 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 378753006283 Walker A/P-loop; other site 378753006284 ATP binding site [chemical binding]; other site 378753006285 Q-loop/lid; other site 378753006286 ABC transporter signature motif; other site 378753006287 Walker B; other site 378753006288 D-loop; other site 378753006289 H-loop/switch region; other site 378753006290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753006291 DNA-binding site [nucleotide binding]; DNA binding site 378753006292 prenyltransferase; Reviewed; Region: ubiA; PRK13105 378753006293 UbiA prenyltransferase family; Region: UbiA; pfam01040 378753006294 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 378753006295 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 378753006296 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753006297 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 378753006298 active site lid residues [active] 378753006299 substrate binding pocket [chemical binding]; other site 378753006300 catalytic residues [active] 378753006301 substrate-Mg2+ binding site; other site 378753006302 aspartate-rich region 1; other site 378753006303 aspartate-rich region 2; other site 378753006304 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 378753006305 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 378753006306 substrate binding pocket [chemical binding]; other site 378753006307 aspartate-rich region 2; other site 378753006308 substrate-Mg2+ binding site; other site 378753006309 MarR family; Region: MarR_2; pfam12802 378753006310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753006311 Fructosamine kinase; Region: Fructosamin_kin; cl17579 378753006312 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 378753006313 FAD binding site [chemical binding]; other site 378753006314 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 378753006315 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 378753006316 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 378753006317 substrate binding site [chemical binding]; other site 378753006318 THF binding site; other site 378753006319 zinc-binding site [ion binding]; other site 378753006320 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 378753006321 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 378753006322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753006323 catalytic residue [active] 378753006324 cystathionine gamma-synthase; Provisional; Region: PRK07811 378753006325 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 378753006326 homodimer interface [polypeptide binding]; other site 378753006327 substrate-cofactor binding pocket; other site 378753006328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753006329 catalytic residue [active] 378753006330 acyl-CoA synthetase; Validated; Region: PRK08162 378753006331 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 378753006332 acyl-activating enzyme (AAE) consensus motif; other site 378753006333 putative active site [active] 378753006334 AMP binding site [chemical binding]; other site 378753006335 putative CoA binding site [chemical binding]; other site 378753006336 acyl-coenzyme A oxidase; Region: PLN02526 378753006337 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753006338 active site 378753006339 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753006340 substrate binding site [chemical binding]; other site 378753006341 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 378753006342 oxyanion hole (OAH) forming residues; other site 378753006343 trimer interface [polypeptide binding]; other site 378753006344 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 378753006345 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 378753006346 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 378753006347 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006348 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 378753006349 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 378753006350 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 378753006351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753006352 dimer interface [polypeptide binding]; other site 378753006353 conserved gate region; other site 378753006354 ABC-ATPase subunit interface; other site 378753006355 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 378753006356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 378753006357 dimer interface [polypeptide binding]; other site 378753006358 conserved gate region; other site 378753006359 putative PBP binding loops; other site 378753006360 ABC-ATPase subunit interface; other site 378753006361 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 378753006362 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 378753006363 Walker A/P-loop; other site 378753006364 ATP binding site [chemical binding]; other site 378753006365 Q-loop/lid; other site 378753006366 ABC transporter signature motif; other site 378753006367 Walker B; other site 378753006368 D-loop; other site 378753006369 H-loop/switch region; other site 378753006370 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 378753006371 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 378753006372 Walker A/P-loop; other site 378753006373 ATP binding site [chemical binding]; other site 378753006374 Q-loop/lid; other site 378753006375 ABC transporter signature motif; other site 378753006376 Walker B; other site 378753006377 D-loop; other site 378753006378 H-loop/switch region; other site 378753006379 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 378753006380 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 378753006381 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 378753006382 L-asparagine permease; Provisional; Region: PRK15049 378753006383 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 378753006384 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753006385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753006386 Coenzyme A binding pocket [chemical binding]; other site 378753006387 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378753006388 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 378753006389 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753006390 MarR family; Region: MarR_2; pfam12802 378753006391 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 378753006392 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 378753006393 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 378753006394 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 378753006395 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 378753006396 putative active site [active] 378753006397 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 378753006398 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 378753006399 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 378753006400 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 378753006401 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378753006402 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 378753006403 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 378753006404 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 378753006405 carboxyltransferase (CT) interaction site; other site 378753006406 biotinylation site [posttranslational modification]; other site 378753006407 Transcriptional regulators [Transcription]; Region: GntR; COG1802 378753006408 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753006409 DNA-binding site [nucleotide binding]; DNA binding site 378753006410 FCD domain; Region: FCD; pfam07729 378753006411 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 378753006412 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 378753006413 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 378753006414 Tic20-like protein; Region: Tic20; pfam09685 378753006415 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 378753006416 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 378753006417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753006418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006419 CAAX protease self-immunity; Region: Abi; pfam02517 378753006420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753006421 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 378753006422 NAD(P) binding site [chemical binding]; other site 378753006423 active site 378753006424 TspO/MBR family; Region: TspO_MBR; pfam03073 378753006425 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 378753006426 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753006427 putative DNA binding site [nucleotide binding]; other site 378753006428 putative Zn2+ binding site [ion binding]; other site 378753006429 AsnC family; Region: AsnC_trans_reg; pfam01037 378753006430 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 378753006431 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 378753006432 tetramer interface [polypeptide binding]; other site 378753006433 TPP-binding site [chemical binding]; other site 378753006434 heterodimer interface [polypeptide binding]; other site 378753006435 phosphorylation loop region [posttranslational modification] 378753006436 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 378753006437 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 378753006438 alpha subunit interface [polypeptide binding]; other site 378753006439 TPP binding site [chemical binding]; other site 378753006440 heterodimer interface [polypeptide binding]; other site 378753006441 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 378753006442 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 378753006443 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 378753006444 E3 interaction surface; other site 378753006445 lipoyl attachment site [posttranslational modification]; other site 378753006446 e3 binding domain; Region: E3_binding; pfam02817 378753006447 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 378753006448 Lysine efflux permease [General function prediction only]; Region: COG1279 378753006449 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 378753006450 putative FMN binding site [chemical binding]; other site 378753006451 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753006452 MarR family; Region: MarR; pfam01047 378753006453 Uncharacterized protein conserved in bacteria (DUF2186); Region: DUF2186; pfam09952 378753006454 Predicted nucleotidyltransferase [General function prediction only]; Region: COG4849 378753006455 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 378753006456 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753006457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753006458 homodimer interface [polypeptide binding]; other site 378753006459 catalytic residue [active] 378753006460 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 378753006461 agmatinase; Region: agmatinase; TIGR01230 378753006462 oligomer interface [polypeptide binding]; other site 378753006463 putative active site [active] 378753006464 Mn binding site [ion binding]; other site 378753006465 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u3; cd11479 378753006466 Na binding site [ion binding]; other site 378753006467 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 378753006468 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 378753006469 PYR/PP interface [polypeptide binding]; other site 378753006470 dimer interface [polypeptide binding]; other site 378753006471 TPP binding site [chemical binding]; other site 378753006472 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 378753006473 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 378753006474 TPP-binding site [chemical binding]; other site 378753006475 AAA domain; Region: AAA_17; pfam13207 378753006476 xanthine permease; Region: pbuX; TIGR03173 378753006477 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 378753006478 nucleoside/Zn binding site; other site 378753006479 dimer interface [polypeptide binding]; other site 378753006480 catalytic motif [active] 378753006481 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 378753006482 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 378753006483 XdhC Rossmann domain; Region: XdhC_C; pfam13478 378753006484 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 378753006485 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 378753006486 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 378753006487 Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A [Nucleotide transport and metabolism]; Region: XdhA; COG4630 378753006488 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 378753006489 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 378753006490 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 378753006491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753006492 hydroxyglutarate oxidase; Provisional; Region: PRK11728 378753006493 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 378753006494 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 378753006495 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 378753006496 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 378753006497 Sarcosine oxidase, gamma subunit family; Region: SoxG; pfam04268 378753006498 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 378753006499 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 378753006500 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 378753006501 putative active site [active] 378753006502 putative substrate binding site [chemical binding]; other site 378753006503 putative cosubstrate binding site; other site 378753006504 catalytic site [active] 378753006505 Transcriptional regulators [Transcription]; Region: GntR; COG1802 378753006506 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753006507 DNA-binding site [nucleotide binding]; DNA binding site 378753006508 FCD domain; Region: FCD; pfam07729 378753006509 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 378753006510 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 378753006511 TAP-like protein; Region: Abhydrolase_4; pfam08386 378753006512 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 378753006513 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 378753006514 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 378753006515 dimer interface [polypeptide binding]; other site 378753006516 putative anticodon binding site; other site 378753006517 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 378753006518 motif 1; other site 378753006519 dimer interface [polypeptide binding]; other site 378753006520 active site 378753006521 motif 2; other site 378753006522 motif 3; other site 378753006523 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378753006524 Histidine kinase; Region: HisKA_3; pfam07730 378753006525 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753006526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753006527 active site 378753006528 phosphorylation site [posttranslational modification] 378753006529 intermolecular recognition site; other site 378753006530 dimerization interface [polypeptide binding]; other site 378753006531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753006532 DNA binding residues [nucleotide binding] 378753006533 dimerization interface [polypeptide binding]; other site 378753006534 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 378753006535 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 378753006536 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753006537 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 378753006538 Cytochrome P450; Region: p450; cl12078 378753006539 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 378753006540 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753006541 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 378753006542 Peptidase family M23; Region: Peptidase_M23; pfam01551 378753006543 DinB superfamily; Region: DinB_2; pfam12867 378753006544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 378753006545 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753006546 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 378753006547 NAD(P) binding site [chemical binding]; other site 378753006548 catalytic residues [active] 378753006549 High-affinity nickel-transport protein; Region: NicO; cl00964 378753006550 UreD urease accessory protein; Region: UreD; cl00530 378753006551 UreD urease accessory protein; Region: UreD; cl00530 378753006552 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 378753006553 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 378753006554 UreF; Region: UreF; pfam01730 378753006555 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 378753006556 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 378753006557 dimer interface [polypeptide binding]; other site 378753006558 catalytic residues [active] 378753006559 urease subunit alpha; Reviewed; Region: ureC; PRK13207 378753006560 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 378753006561 subunit interactions [polypeptide binding]; other site 378753006562 active site 378753006563 flap region; other site 378753006564 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 378753006565 gamma-beta subunit interface [polypeptide binding]; other site 378753006566 alpha-beta subunit interface [polypeptide binding]; other site 378753006567 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 378753006568 alpha-gamma subunit interface [polypeptide binding]; other site 378753006569 beta-gamma subunit interface [polypeptide binding]; other site 378753006570 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 378753006571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006572 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753006573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006574 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 378753006575 FtsX-like permease family; Region: FtsX; pfam02687 378753006576 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 378753006577 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 378753006578 Walker A/P-loop; other site 378753006579 ATP binding site [chemical binding]; other site 378753006580 Q-loop/lid; other site 378753006581 ABC transporter signature motif; other site 378753006582 Walker B; other site 378753006583 D-loop; other site 378753006584 Response regulator receiver domain; Region: Response_reg; pfam00072 378753006585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753006586 active site 378753006587 phosphorylation site [posttranslational modification] 378753006588 intermolecular recognition site; other site 378753006589 dimerization interface [polypeptide binding]; other site 378753006590 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 378753006591 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 378753006592 DNA binding residues [nucleotide binding] 378753006593 dimerization interface [polypeptide binding]; other site 378753006594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 378753006595 Histidine kinase; Region: HisKA_3; pfam07730 378753006596 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753006597 ATP binding site [chemical binding]; other site 378753006598 Mg2+ binding site [ion binding]; other site 378753006599 G-X-G motif; other site 378753006600 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 378753006601 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 378753006602 Domain of unknown function DUF21; Region: DUF21; pfam01595 378753006603 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 378753006604 Domain of unknown function DUF21; Region: DUF21; pfam01595 378753006605 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 378753006606 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 378753006607 Transporter associated domain; Region: CorC_HlyC; smart01091 378753006608 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 378753006609 putative hydrophobic ligand binding site [chemical binding]; other site 378753006610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753006611 TIGR01777 family protein; Region: yfcH 378753006612 NAD(P) binding site [chemical binding]; other site 378753006613 active site 378753006614 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 378753006615 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 378753006616 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 378753006617 Predicted amidohydrolase [General function prediction only]; Region: COG0388 378753006618 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 378753006619 putative active site [active] 378753006620 catalytic triad [active] 378753006621 putative dimer interface [polypeptide binding]; other site 378753006622 Predicted membrane protein [Function unknown]; Region: COG4270 378753006623 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 378753006624 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 378753006625 active site residue [active] 378753006626 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 378753006627 active site residue [active] 378753006628 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 378753006629 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 378753006630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753006631 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 378753006632 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 378753006633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 378753006634 substrate binding site [chemical binding]; other site 378753006635 oxyanion hole (OAH) forming residues; other site 378753006636 trimer interface [polypeptide binding]; other site 378753006637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 378753006638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753006639 Coenzyme A binding pocket [chemical binding]; other site 378753006640 YCII-related domain; Region: YCII; cl00999 378753006641 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 378753006642 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 378753006643 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 378753006644 Dienelactone hydrolase family; Region: DLH; pfam01738 378753006645 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 378753006646 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 378753006647 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 378753006648 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 378753006649 tetramer interface [polypeptide binding]; other site 378753006650 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 378753006651 tetramer interface [polypeptide binding]; other site 378753006652 active site 378753006653 metal binding site [ion binding]; metal-binding site 378753006654 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 378753006655 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 378753006656 NAD binding site [chemical binding]; other site 378753006657 catalytic residues [active] 378753006658 Transcriptional regulators [Transcription]; Region: GntR; COG1802 378753006659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 378753006660 DNA-binding site [nucleotide binding]; DNA binding site 378753006661 FCD domain; Region: FCD; pfam07729 378753006662 hypothetical protein; Provisional; Region: PRK12764 378753006663 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 378753006664 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 378753006665 phenol 2-monooxygenase; Provisional; Region: PRK08294 378753006666 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 378753006667 FAD-dependent Phenol hydoxylase (PHOX) family, C-terminal TRX-fold domain; composed of proteins similar to PHOX from the aerobic topsoil yeast Trichosporon cutaneum. PHOX is a flavoprotein monooxygenase that catalyzes the hydroxylation of phenol and...; Region: PHOX_C; cd02979 378753006668 dimer interface [polypeptide binding]; other site 378753006669 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 378753006670 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 378753006671 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 378753006672 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 378753006673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006674 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 378753006675 Transposase; Region: DDE_Tnp_ISL3; pfam01610 378753006676 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 378753006677 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 378753006678 Nitronate monooxygenase; Region: NMO; pfam03060 378753006679 FMN binding site [chemical binding]; other site 378753006680 substrate binding site [chemical binding]; other site 378753006681 putative catalytic residue [active] 378753006682 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 378753006683 nudix motif; other site 378753006684 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 378753006685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006686 putative substrate translocation pore; other site 378753006687 Survival protein SurE; Region: SurE; pfam01975 378753006688 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 378753006689 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 378753006690 substrate binding site [chemical binding]; other site 378753006691 ATP binding site [chemical binding]; other site 378753006692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753006693 Coenzyme A binding pocket [chemical binding]; other site 378753006694 ChaB; Region: ChaB; pfam06150 378753006695 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 378753006696 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 378753006697 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 378753006698 putative dimer interface [polypeptide binding]; other site 378753006699 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 378753006700 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 378753006701 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 378753006702 MMPL family; Region: MMPL; pfam03176 378753006703 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 378753006704 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 378753006705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753006706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006707 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 378753006708 catalytic residue [active] 378753006709 D-serine dehydratase; Provisional; Region: PRK02991 378753006710 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 378753006711 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 378753006712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006713 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753006714 putative substrate translocation pore; other site 378753006715 choline dehydrogenase; Validated; Region: PRK02106 378753006716 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753006717 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 378753006718 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 378753006719 DNA-binding site [nucleotide binding]; DNA binding site 378753006720 RNA-binding motif; other site 378753006721 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 378753006722 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 378753006723 FMN binding site [chemical binding]; other site 378753006724 active site 378753006725 substrate binding site [chemical binding]; other site 378753006726 catalytic residue [active] 378753006727 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 378753006728 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 378753006729 NAD(P) binding site [chemical binding]; other site 378753006730 catalytic residues [active] 378753006731 Amino acid permease; Region: AA_permease; pfam00324 378753006732 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 378753006733 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 378753006734 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 378753006735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378753006736 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 378753006737 CoenzymeA binding site [chemical binding]; other site 378753006738 subunit interaction site [polypeptide binding]; other site 378753006739 PHB binding site; other site 378753006740 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 378753006741 classical (c) SDRs; Region: SDR_c; cd05233 378753006742 NAD(P) binding site [chemical binding]; other site 378753006743 active site 378753006744 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 378753006745 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 378753006746 active site 378753006747 metabolite-proton symporter; Region: 2A0106; TIGR00883 378753006748 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006749 putative substrate translocation pore; other site 378753006750 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 378753006751 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 378753006752 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 378753006753 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753006754 homodimer interface [polypeptide binding]; other site 378753006755 catalytic residue [active] 378753006756 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 378753006757 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 378753006758 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 378753006759 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 378753006760 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 378753006761 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 378753006762 AlkA N-terminal domain; Region: AlkA_N; pfam06029 378753006763 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 378753006764 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 378753006765 minor groove reading motif; other site 378753006766 helix-hairpin-helix signature motif; other site 378753006767 substrate binding pocket [chemical binding]; other site 378753006768 active site 378753006769 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 378753006770 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 378753006771 DNA binding site [nucleotide binding] 378753006772 active site 378753006773 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 378753006774 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 378753006775 active site 378753006776 Predicted membrane protein [Function unknown]; Region: COG4270 378753006777 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 378753006778 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 378753006779 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 378753006780 putative NAD(P) binding site [chemical binding]; other site 378753006781 catalytic Zn binding site [ion binding]; other site 378753006782 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 378753006783 active site 378753006784 phosphorylation site [posttranslational modification] 378753006785 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 378753006786 active site 378753006787 P-loop; other site 378753006788 phosphorylation site [posttranslational modification] 378753006789 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 378753006790 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 378753006791 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 378753006792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 378753006793 Coenzyme A binding pocket [chemical binding]; other site 378753006794 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 378753006795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753006796 S-adenosylmethionine binding site [chemical binding]; other site 378753006797 VanW like protein; Region: VanW; pfam04294 378753006798 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 378753006799 hydroperoxidase II; Provisional; Region: katE; PRK11249 378753006800 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 378753006801 heme binding pocket [chemical binding]; other site 378753006802 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 378753006803 domain interactions; other site 378753006804 Zinc finger domain containing protein (CDGSH-type) [Function unknown]; Region: COG3369 378753006805 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 378753006806 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 378753006807 Fic/DOC family; Region: Fic; cl00960 378753006808 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 378753006809 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378753006810 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 378753006811 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 378753006812 Ligand Binding Site [chemical binding]; other site 378753006813 Electron transfer flavoprotein domain; Region: ETF; pfam01012 378753006814 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 378753006815 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 378753006816 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 378753006817 putative active site [active] 378753006818 putative catalytic site [active] 378753006819 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753006820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753006821 active site 378753006822 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 378753006823 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 378753006824 ATP-grasp domain; Region: ATP-grasp_4; cl17255 378753006825 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 378753006826 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 378753006827 carboxyltransferase (CT) interaction site; other site 378753006828 biotinylation site [posttranslational modification]; other site 378753006829 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 378753006830 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 378753006831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753006832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006833 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 378753006834 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 378753006835 active site 378753006836 AMP-binding domain protein; Validated; Region: PRK08315 378753006837 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 378753006838 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 378753006839 acyl-activating enzyme (AAE) consensus motif; other site 378753006840 acyl-activating enzyme (AAE) consensus motif; other site 378753006841 putative AMP binding site [chemical binding]; other site 378753006842 putative active site [active] 378753006843 putative CoA binding site [chemical binding]; other site 378753006844 Helix-turn-helix domain; Region: HTH_17; cl17695 378753006845 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 378753006846 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 378753006847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753006848 active site 378753006849 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 378753006850 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 378753006851 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 378753006852 threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672 378753006853 MarR family; Region: MarR_2; cl17246 378753006854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 378753006855 myosin-cross-reactive antigen; Provisional; Region: PRK13977 378753006856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 378753006857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 378753006858 putative proline-specific permease; Provisional; Region: proY; PRK10580 378753006859 Spore germination protein; Region: Spore_permease; cl17796 378753006860 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 378753006861 putative active site [active] 378753006862 putative metal binding site [ion binding]; other site 378753006863 Transcriptional regulator [Transcription]; Region: IclR; COG1414 378753006864 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 378753006865 putative DNA binding site [nucleotide binding]; other site 378753006866 putative Zn2+ binding site [ion binding]; other site 378753006867 Bacterial transcriptional regulator; Region: IclR; pfam01614 378753006868 urocanate hydratase; Provisional; Region: PRK05414 378753006869 imidazolonepropionase; Provisional; Region: PRK14085 378753006870 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 378753006871 active site 378753006872 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 378753006873 Nucleoside recognition; Region: Gate; pfam07670 378753006874 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 378753006875 active sites [active] 378753006876 tetramer interface [polypeptide binding]; other site 378753006877 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 378753006878 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 378753006879 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378753006880 Uncharacterized conserved protein [Function unknown]; Region: COG1479 378753006881 Protein of unknown function DUF262; Region: DUF262; pfam03235 378753006882 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 378753006883 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 378753006884 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 378753006885 AAA domain; Region: AAA_12; pfam13087 378753006886 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 378753006887 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 378753006888 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 378753006889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006890 putative substrate translocation pore; other site 378753006891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006892 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 378753006893 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 378753006894 CPxP motif; other site 378753006895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 378753006896 NADH(P)-binding; Region: NAD_binding_10; pfam13460 378753006897 NAD(P) binding site [chemical binding]; other site 378753006898 active site 378753006899 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 378753006900 chorismate binding enzyme; Region: Chorismate_bind; cl10555 378753006901 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 378753006902 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 378753006903 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 378753006904 homodimer interface [polypeptide binding]; other site 378753006905 substrate-cofactor binding pocket; other site 378753006906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753006907 catalytic residue [active] 378753006908 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 378753006909 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 378753006910 Prostaglandin dehydrogenases; Region: PGDH; cd05288 378753006911 NAD(P) binding site [chemical binding]; other site 378753006912 substrate binding site [chemical binding]; other site 378753006913 dimer interface [polypeptide binding]; other site 378753006914 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 378753006915 CHASE3 domain; Region: CHASE3; pfam05227 378753006916 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 378753006917 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 378753006918 dimer interface [polypeptide binding]; other site 378753006919 phosphorylation site [posttranslational modification] 378753006920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 378753006921 ATP binding site [chemical binding]; other site 378753006922 Mg2+ binding site [ion binding]; other site 378753006923 G-X-G motif; other site 378753006924 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 378753006925 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 378753006926 DXD motif; other site 378753006927 Response regulator receiver domain; Region: Response_reg; pfam00072 378753006928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 378753006929 active site 378753006930 phosphorylation site [posttranslational modification] 378753006931 intermolecular recognition site; other site 378753006932 dimerization interface [polypeptide binding]; other site 378753006933 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 378753006934 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 378753006935 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 378753006936 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 378753006937 Mrr N-terminal domain; Region: Mrr_N; pfam14338 378753006938 Restriction endonuclease; Region: Mrr_cat; pfam04471 378753006939 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 378753006940 GIY-YIG motif/motif A; other site 378753006941 active site 378753006942 catalytic site [active] 378753006943 metal binding site [ion binding]; metal-binding site 378753006944 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 378753006945 Major Facilitator Superfamily; Region: MFS_1; pfam07690 378753006946 putative substrate translocation pore; other site 378753006947 MarR family; Region: MarR_2; pfam12802 378753006948 Transcriptional regulators [Transcription]; Region: MarR; COG1846 378753006949 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 378753006950 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 378753006951 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 378753006952 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 378753006953 tetrameric interface [polypeptide binding]; other site 378753006954 NAD binding site [chemical binding]; other site 378753006955 catalytic residues [active] 378753006956 hypothetical protein; Provisional; Region: PRK06062 378753006957 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 378753006958 inhibitor-cofactor binding pocket; inhibition site 378753006959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 378753006960 catalytic residue [active] 378753006961 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 378753006962 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 378753006963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 378753006964 ATP binding site [chemical binding]; other site 378753006965 putative Mg++ binding site [ion binding]; other site 378753006966 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 378753006967 nucleotide binding region [chemical binding]; other site 378753006968 ATP-binding site [chemical binding]; other site 378753006969 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 378753006970 HRDC domain; Region: HRDC; pfam00570 378753006971 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 378753006972 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 378753006973 replicative DNA helicase; Region: DnaB; TIGR00665 378753006974 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 378753006975 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 378753006976 Walker A motif; other site 378753006977 ATP binding site [chemical binding]; other site 378753006978 Walker B motif; other site 378753006979 DNA binding loops [nucleotide binding] 378753006980 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 378753006981 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 378753006982 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 378753006983 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 378753006984 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 378753006985 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 378753006986 dimer interface [polypeptide binding]; other site 378753006987 ssDNA binding site [nucleotide binding]; other site 378753006988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 378753006989 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 378753006990 TM2 domain; Region: TM2; pfam05154 378753006991 Predicted integral membrane protein [Function unknown]; Region: COG5650 378753006992 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 378753006993 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 378753006994 active site 378753006995 NTP binding site [chemical binding]; other site 378753006996 metal binding triad [ion binding]; metal-binding site 378753006997 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 378753006998 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 378753006999 Zn2+ binding site [ion binding]; other site 378753007000 Mg2+ binding site [ion binding]; other site 378753007001 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 378753007002 active site 378753007003 Ap6A binding site [chemical binding]; other site 378753007004 nudix motif; other site 378753007005 metal binding site [ion binding]; metal-binding site 378753007006 integral membrane protein MviN; Region: mviN; TIGR01695 378753007007 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 378753007008 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 378753007009 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 378753007010 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 378753007011 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 378753007012 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 378753007013 catalytic residues [active] 378753007014 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 378753007015 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378753007016 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 378753007017 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 378753007018 active site 378753007019 metal binding site [ion binding]; metal-binding site 378753007020 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 378753007021 ParB-like nuclease domain; Region: ParB; smart00470 378753007022 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 378753007023 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 378753007024 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 378753007025 P-loop; other site 378753007026 Magnesium ion binding site [ion binding]; other site 378753007027 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 378753007028 Magnesium ion binding site [ion binding]; other site 378753007029 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 378753007030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 378753007031 S-adenosylmethionine binding site [chemical binding]; other site 378753007032 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 378753007033 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 378753007034 G-X-X-G motif; other site 378753007035 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 378753007036 RxxxH motif; other site 378753007037 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 378753007038 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 378753007039 Haemolytic domain; Region: Haemolytic; cl00506 378753007040 Ribonuclease P; Region: Ribonuclease_P; cl00457