-- dump date 20140619_121946 -- class Genbank::misc_feature -- table misc_feature_note -- id note 479435000001 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 479435000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435000003 Walker A motif; other site 479435000004 ATP binding site [chemical binding]; other site 479435000005 Walker B motif; other site 479435000006 arginine finger; other site 479435000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 479435000008 DnaA box-binding interface [nucleotide binding]; other site 479435000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 479435000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 479435000011 putative DNA binding surface [nucleotide binding]; other site 479435000012 dimer interface [polypeptide binding]; other site 479435000013 beta-clamp/clamp loader binding surface; other site 479435000014 beta-clamp/translesion DNA polymerase binding surface; other site 479435000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 479435000017 recombination protein F; Reviewed; Region: recF; PRK00064 479435000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 479435000019 Walker A/P-loop; other site 479435000020 ATP binding site [chemical binding]; other site 479435000021 Q-loop/lid; other site 479435000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435000023 ABC transporter signature motif; other site 479435000024 Walker B; other site 479435000025 D-loop; other site 479435000026 H-loop/switch region; other site 479435000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 479435000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 479435000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 479435000030 anchoring element; other site 479435000031 dimer interface [polypeptide binding]; other site 479435000032 ATP binding site [chemical binding]; other site 479435000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 479435000034 active site 479435000035 putative metal-binding site [ion binding]; other site 479435000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 479435000037 DNA gyrase subunit A; Validated; Region: PRK05560 479435000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 479435000039 CAP-like domain; other site 479435000040 active site 479435000041 primary dimer interface [polypeptide binding]; other site 479435000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435000047 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 479435000048 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435000049 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435000050 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000051 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000052 WHG domain; Region: WHG; pfam13305 479435000053 short chain dehydrogenase; Provisional; Region: PRK05854 479435000054 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000055 NAD(P) binding site [chemical binding]; other site 479435000056 active site 479435000057 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 479435000058 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 479435000059 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435000060 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479435000061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000062 NAD(P) binding site [chemical binding]; other site 479435000063 active site 479435000064 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435000065 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 479435000066 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479435000067 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000069 FAD binding domain; Region: FAD_binding_4; pfam01565 479435000070 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435000071 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435000072 putative metal binding site [ion binding]; other site 479435000073 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435000074 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435000075 sugar binding site [chemical binding]; other site 479435000076 classical (c) SDRs; Region: SDR_c; cd05233 479435000077 NAD(P) binding site [chemical binding]; other site 479435000078 active site 479435000079 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 479435000080 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 479435000081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000083 PPOX class probable F420-dependent enzyme, MSMEG_5819 family; Region: PPOX_MSMEG_5819; TIGR04023 479435000084 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435000085 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 479435000086 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 479435000087 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 479435000088 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 479435000089 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435000090 DNA binding site [nucleotide binding] 479435000091 active site 479435000092 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435000093 active site 479435000094 Rhomboid family; Region: Rhomboid; pfam01694 479435000095 hypothetical protein; Provisional; Region: PRK07236 479435000096 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 479435000097 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479435000098 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000099 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435000100 DNA binding site [nucleotide binding] 479435000101 domain linker motif; other site 479435000102 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000103 ligand binding site [chemical binding]; other site 479435000104 dimerization interface [polypeptide binding]; other site 479435000105 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 479435000106 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 479435000107 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435000108 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435000109 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435000110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479435000111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000112 dimer interface [polypeptide binding]; other site 479435000113 ABC-ATPase subunit interface; other site 479435000114 putative PBP binding loops; other site 479435000115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000117 dimer interface [polypeptide binding]; other site 479435000118 conserved gate region; other site 479435000119 putative PBP binding loops; other site 479435000120 ABC-ATPase subunit interface; other site 479435000121 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435000122 active site 479435000123 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 479435000124 putative substrate binding site [chemical binding]; other site 479435000125 active site 479435000126 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435000127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000128 DNA-binding site [nucleotide binding]; DNA binding site 479435000129 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435000130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000131 homodimer interface [polypeptide binding]; other site 479435000132 catalytic residue [active] 479435000133 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 479435000134 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435000135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435000136 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435000137 Walker A/P-loop; other site 479435000138 ATP binding site [chemical binding]; other site 479435000139 Q-loop/lid; other site 479435000140 ABC transporter signature motif; other site 479435000141 Walker B; other site 479435000142 D-loop; other site 479435000143 H-loop/switch region; other site 479435000144 EXLDI protein; Region: EXLDI; TIGR04342 479435000145 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435000146 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 479435000147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 479435000148 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479435000149 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 479435000150 Glutamine amidotransferase class-I; Region: GATase; pfam00117 479435000151 glutamine binding [chemical binding]; other site 479435000152 catalytic triad [active] 479435000153 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435000154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435000155 active site 479435000156 ATP binding site [chemical binding]; other site 479435000157 substrate binding site [chemical binding]; other site 479435000158 activation loop (A-loop); other site 479435000159 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435000160 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435000161 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435000162 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 479435000163 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 479435000164 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 479435000165 active site 479435000166 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479435000167 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435000168 phosphopeptide binding site; other site 479435000169 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 479435000170 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435000171 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479435000172 phosphopeptide binding site; other site 479435000173 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 479435000174 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435000175 DNA binding residues [nucleotide binding] 479435000176 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435000177 dimerization interface [polypeptide binding]; other site 479435000178 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435000179 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435000180 active site 479435000181 catalytic residues [active] 479435000182 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 479435000183 putative hydrophobic ligand binding site [chemical binding]; other site 479435000184 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 479435000185 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435000186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000187 homodimer interface [polypeptide binding]; other site 479435000188 catalytic residue [active] 479435000189 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435000190 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435000191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000192 dimer interface [polypeptide binding]; other site 479435000193 conserved gate region; other site 479435000194 putative PBP binding loops; other site 479435000195 ABC-ATPase subunit interface; other site 479435000196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000197 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000198 dimer interface [polypeptide binding]; other site 479435000199 conserved gate region; other site 479435000200 putative PBP binding loops; other site 479435000201 ABC-ATPase subunit interface; other site 479435000202 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435000203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000204 DNA-binding site [nucleotide binding]; DNA binding site 479435000205 UTRA domain; Region: UTRA; pfam07702 479435000206 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 479435000207 active site 479435000208 catalytic residues [active] 479435000209 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435000212 DNA binding residues [nucleotide binding] 479435000213 Endonuclease I; Region: Endonuclease_1; pfam04231 479435000214 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 479435000215 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435000216 putative metal binding site [ion binding]; other site 479435000217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435000218 dimerization interface [polypeptide binding]; other site 479435000219 putative DNA binding site [nucleotide binding]; other site 479435000220 putative Zn2+ binding site [ion binding]; other site 479435000221 Cation efflux family; Region: Cation_efflux; cl00316 479435000222 AAA ATPase domain; Region: AAA_16; pfam13191 479435000223 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479435000224 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479435000225 FAD binding pocket [chemical binding]; other site 479435000226 FAD binding motif [chemical binding]; other site 479435000227 phosphate binding motif [ion binding]; other site 479435000228 NAD binding pocket [chemical binding]; other site 479435000229 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 479435000230 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 479435000231 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 479435000232 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 479435000233 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 479435000234 apolar tunnel; other site 479435000235 heme binding site [chemical binding]; other site 479435000236 dimerization interface [polypeptide binding]; other site 479435000237 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 479435000238 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 479435000239 Walker A/P-loop; other site 479435000240 ATP binding site [chemical binding]; other site 479435000241 Q-loop/lid; other site 479435000242 ABC transporter signature motif; other site 479435000243 Walker B; other site 479435000244 D-loop; other site 479435000245 H-loop/switch region; other site 479435000246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000247 dimer interface [polypeptide binding]; other site 479435000248 conserved gate region; other site 479435000249 putative PBP binding loops; other site 479435000250 ABC-ATPase subunit interface; other site 479435000251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000252 dimer interface [polypeptide binding]; other site 479435000253 conserved gate region; other site 479435000254 ABC-ATPase subunit interface; other site 479435000255 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 479435000256 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 479435000257 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435000258 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479435000259 P-loop; other site 479435000260 Magnesium ion binding site [ion binding]; other site 479435000261 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435000262 putative DNA binding site [nucleotide binding]; other site 479435000263 putative Zn2+ binding site [ion binding]; other site 479435000264 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435000265 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435000266 nucleotide binding site [chemical binding]; other site 479435000267 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 479435000268 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435000269 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 479435000270 active site 479435000271 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435000272 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435000273 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435000274 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435000275 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435000276 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 479435000277 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435000278 MarR family; Region: MarR_2; pfam12802 479435000279 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435000280 nudix motif; other site 479435000281 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435000282 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435000283 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000284 NAD(P) binding site [chemical binding]; other site 479435000285 active site 479435000286 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000287 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000288 Proline dehydrogenase; Region: Pro_dh; cl03282 479435000289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000290 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435000291 putative substrate translocation pore; other site 479435000292 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 479435000293 4-coumarate--CoA ligase; Region: PLN02246 479435000294 4-Coumarate-CoA Ligase (4CL); Region: 4CL; cd05904 479435000295 acyl-activating enzyme (AAE) consensus motif; other site 479435000296 active site 479435000297 putative CoA binding site [chemical binding]; other site 479435000298 AMP binding site [chemical binding]; other site 479435000299 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435000300 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 479435000301 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 479435000302 active site 479435000303 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 479435000304 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435000305 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435000306 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 479435000307 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479435000308 carboxyltransferase (CT) interaction site; other site 479435000309 biotinylation site [posttranslational modification]; other site 479435000310 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 479435000311 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 479435000312 Probable transposase; Region: OrfB_IS605; pfam01385 479435000313 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 479435000314 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 479435000315 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435000316 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 479435000317 active site 479435000318 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 479435000319 TIGR03084 family protein; Region: TIGR03084 479435000320 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435000321 Wyosine base formation; Region: Wyosine_form; pfam08608 479435000322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435000323 dimerization interface [polypeptide binding]; other site 479435000324 putative DNA binding site [nucleotide binding]; other site 479435000325 putative Zn2+ binding site [ion binding]; other site 479435000326 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 479435000327 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 479435000328 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435000329 PKD domain; Region: PKD; pfam00801 479435000330 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435000331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435000332 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435000333 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435000334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000335 ABC-ATPase subunit interface; other site 479435000336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000338 dimer interface [polypeptide binding]; other site 479435000339 conserved gate region; other site 479435000340 putative PBP binding loops; other site 479435000341 ABC-ATPase subunit interface; other site 479435000342 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435000343 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435000344 inhibitor site; inhibition site 479435000345 active site 479435000346 dimer interface [polypeptide binding]; other site 479435000347 catalytic residue [active] 479435000348 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435000349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000350 DNA-binding site [nucleotide binding]; DNA binding site 479435000351 FCD domain; Region: FCD; pfam07729 479435000352 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 479435000353 catalytic site [active] 479435000354 BNR repeat-like domain; Region: BNR_2; pfam13088 479435000355 Asp-box motif; other site 479435000356 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 479435000357 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 479435000358 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479435000359 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 479435000360 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435000361 hydrophobic ligand binding site; other site 479435000362 Predicted membrane protein [Function unknown]; Region: COG1511 479435000363 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 479435000364 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 479435000365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435000366 Walker A/P-loop; other site 479435000367 ATP binding site [chemical binding]; other site 479435000368 Q-loop/lid; other site 479435000369 ABC transporter signature motif; other site 479435000370 Walker B; other site 479435000371 D-loop; other site 479435000372 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000373 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000374 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479435000375 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 479435000376 Moco binding site; other site 479435000377 metal coordination site [ion binding]; other site 479435000378 dimerization interface [polypeptide binding]; other site 479435000379 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435000380 MarR family; Region: MarR; pfam01047 479435000381 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 479435000382 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435000383 active site 479435000384 metal binding site [ion binding]; metal-binding site 479435000385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435000386 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 479435000387 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 479435000388 active site 479435000389 catalytic residues [active] 479435000390 metal binding site [ion binding]; metal-binding site 479435000391 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435000392 active site 479435000393 EcsC protein family; Region: EcsC; pfam12787 479435000394 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435000395 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 479435000396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435000397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000398 Domain of unknown function (DUF385); Region: DUF385; cl04387 479435000399 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 479435000400 adenosine deaminase; Provisional; Region: PRK09358 479435000401 active site 479435000402 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000403 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435000404 DNA binding residues [nucleotide binding] 479435000405 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435000406 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435000407 conserved cys residue [active] 479435000408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435000409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000410 S-adenosylmethionine binding site [chemical binding]; other site 479435000411 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479435000412 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 479435000413 putative DNA binding site [nucleotide binding]; other site 479435000414 catalytic residue [active] 479435000415 putative H2TH interface [polypeptide binding]; other site 479435000416 putative catalytic residues [active] 479435000417 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435000418 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435000419 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479435000420 active site residue [active] 479435000421 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 479435000422 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 479435000423 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435000424 active site 479435000425 metal binding site [ion binding]; metal-binding site 479435000426 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 479435000427 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 479435000428 dimer interface [polypeptide binding]; other site 479435000429 catalytic triad [active] 479435000430 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435000431 HTH domain; Region: HTH_11; pfam08279 479435000432 WYL domain; Region: WYL; pfam13280 479435000433 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435000434 homotrimer interaction site [polypeptide binding]; other site 479435000435 putative active site [active] 479435000436 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435000437 putative hydrophobic ligand binding site [chemical binding]; other site 479435000438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435000439 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435000440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435000441 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435000442 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435000443 Walker A/P-loop; other site 479435000444 ATP binding site [chemical binding]; other site 479435000445 Q-loop/lid; other site 479435000446 ABC transporter signature motif; other site 479435000447 Walker B; other site 479435000448 D-loop; other site 479435000449 H-loop/switch region; other site 479435000450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435000451 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 479435000452 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435000453 Walker A/P-loop; other site 479435000454 ATP binding site [chemical binding]; other site 479435000455 Q-loop/lid; other site 479435000456 ABC transporter signature motif; other site 479435000457 Walker B; other site 479435000458 D-loop; other site 479435000459 H-loop/switch region; other site 479435000460 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000461 putative substrate translocation pore; other site 479435000462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000463 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 479435000464 synthetase active site [active] 479435000465 NTP binding site [chemical binding]; other site 479435000466 metal binding site [ion binding]; metal-binding site 479435000467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479435000468 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435000469 AAA ATPase domain; Region: AAA_16; pfam13191 479435000470 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 479435000471 ADP-ribose binding site [chemical binding]; other site 479435000472 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 479435000473 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435000474 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 479435000475 Na binding site [ion binding]; other site 479435000476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000477 S-adenosylmethionine binding site [chemical binding]; other site 479435000478 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 479435000479 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435000480 DNA binding site [nucleotide binding] 479435000481 active site 479435000482 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435000483 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000484 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435000485 DNA binding residues [nucleotide binding] 479435000486 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 479435000487 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 479435000488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 479435000489 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479435000490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000491 putative PBP binding loops; other site 479435000492 ABC-ATPase subunit interface; other site 479435000493 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479435000494 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 479435000495 Walker A/P-loop; other site 479435000496 ATP binding site [chemical binding]; other site 479435000497 Q-loop/lid; other site 479435000498 ABC transporter signature motif; other site 479435000499 Walker B; other site 479435000500 D-loop; other site 479435000501 H-loop/switch region; other site 479435000502 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 479435000503 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 479435000504 active site 479435000505 non-prolyl cis peptide bond; other site 479435000506 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435000507 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435000508 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 479435000509 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 479435000510 putative active site [active] 479435000511 catalytic site [active] 479435000512 putative metal binding site [ion binding]; other site 479435000513 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435000514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435000515 ATP binding site [chemical binding]; other site 479435000516 Mg2+ binding site [ion binding]; other site 479435000517 G-X-G motif; other site 479435000518 SEC-C motif; Region: SEC-C; pfam02810 479435000519 arginine deiminase; Provisional; Region: PRK01388 479435000520 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435000521 active site 479435000522 Cupin domain; Region: Cupin_2; cl17218 479435000523 hypothetical protein; Provisional; Region: PRK04194 479435000524 AIR carboxylase; Region: AIRC; cl00310 479435000525 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 479435000526 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 479435000527 active site 479435000528 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 479435000529 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 479435000530 seryl-tRNA synthetase; Provisional; Region: PRK05431 479435000531 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 479435000532 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 479435000533 dimer interface [polypeptide binding]; other site 479435000534 active site 479435000535 motif 1; other site 479435000536 motif 2; other site 479435000537 motif 3; other site 479435000538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435000539 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479435000540 active site 479435000541 motif I; other site 479435000542 motif II; other site 479435000543 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479435000544 Transcription factor WhiB; Region: Whib; pfam02467 479435000545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435000546 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479435000547 active site 479435000548 motif I; other site 479435000549 motif II; other site 479435000550 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479435000551 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 479435000552 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435000553 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435000554 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435000555 Walker A/P-loop; other site 479435000556 ATP binding site [chemical binding]; other site 479435000557 Q-loop/lid; other site 479435000558 ABC transporter signature motif; other site 479435000559 Walker B; other site 479435000560 D-loop; other site 479435000561 H-loop/switch region; other site 479435000562 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435000563 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435000564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435000565 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 479435000566 putative dimer interface [polypeptide binding]; other site 479435000567 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435000568 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 479435000569 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 479435000570 NAD(P) binding site [chemical binding]; other site 479435000571 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435000572 Phosphotransferase enzyme family; Region: APH; pfam01636 479435000573 active site 479435000574 ATP binding site [chemical binding]; other site 479435000575 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 479435000576 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 479435000577 GTP binding site; other site 479435000578 Predicted amidohydrolase [General function prediction only]; Region: COG0388 479435000579 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 479435000580 putative active site [active] 479435000581 catalytic triad [active] 479435000582 putative dimer interface [polypeptide binding]; other site 479435000583 hypothetical protein; Provisional; Region: PRK07908 479435000584 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435000585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000586 homodimer interface [polypeptide binding]; other site 479435000587 catalytic residue [active] 479435000588 Cupin superfamily protein; Region: Cupin_4; pfam08007 479435000589 Cupin-like domain; Region: Cupin_8; pfam13621 479435000590 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 479435000591 putative dimer interface [polypeptide binding]; other site 479435000592 putative [2Fe-2S] cluster binding site [ion binding]; other site 479435000593 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 479435000594 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479435000595 putative trimer interface [polypeptide binding]; other site 479435000596 putative CoA binding site [chemical binding]; other site 479435000597 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 479435000598 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435000599 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435000600 RibD C-terminal domain; Region: RibD_C; cl17279 479435000601 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435000602 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435000603 active site 479435000604 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435000605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000606 NAD(P) binding site [chemical binding]; other site 479435000607 active site 479435000608 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 479435000609 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435000610 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435000611 dimerization interface [polypeptide binding]; other site 479435000612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000613 S-adenosylmethionine binding site [chemical binding]; other site 479435000614 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435000615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000616 S-adenosylmethionine binding site [chemical binding]; other site 479435000617 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435000618 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 479435000619 ligand binding site [chemical binding]; other site 479435000620 dimer interface [polypeptide binding]; other site 479435000621 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435000622 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435000623 DNA binding residues [nucleotide binding] 479435000624 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 479435000625 SnoaL-like domain; Region: SnoaL_3; pfam13474 479435000626 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 479435000627 SnoaL-like domain; Region: SnoaL_3; pfam13474 479435000628 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435000629 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000630 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435000631 DNA binding residues [nucleotide binding] 479435000632 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435000633 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 479435000634 active site 479435000635 catalytic residues [active] 479435000636 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 479435000637 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000638 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435000639 DNA binding residues [nucleotide binding] 479435000640 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000641 Phosphotransferase enzyme family; Region: APH; pfam01636 479435000642 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435000643 FAD binding domain; Region: FAD_binding_4; pfam01565 479435000644 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435000645 Berberine and berberine like; Region: BBE; pfam08031 479435000646 Bacterial SH3 domain; Region: SH3_3; pfam08239 479435000647 YCII-related domain; Region: YCII; cl00999 479435000648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000649 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435000650 putative substrate translocation pore; other site 479435000651 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 479435000652 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435000653 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435000654 DNA binding residues [nucleotide binding] 479435000655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000656 NAD(P) binding site [chemical binding]; other site 479435000657 active site 479435000658 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 479435000659 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435000660 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435000661 active site 479435000662 catalytic tetrad [active] 479435000663 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000664 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435000665 DNA binding site [nucleotide binding] 479435000666 domain linker motif; other site 479435000667 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000668 dimerization interface [polypeptide binding]; other site 479435000669 ligand binding site [chemical binding]; other site 479435000670 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435000671 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435000672 Walker A/P-loop; other site 479435000673 ATP binding site [chemical binding]; other site 479435000674 Q-loop/lid; other site 479435000675 ABC transporter signature motif; other site 479435000676 Walker B; other site 479435000677 D-loop; other site 479435000678 H-loop/switch region; other site 479435000679 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479435000680 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435000681 TM-ABC transporter signature motif; other site 479435000682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435000683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435000684 TM-ABC transporter signature motif; other site 479435000685 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 479435000686 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 479435000687 ligand binding site [chemical binding]; other site 479435000688 Domain of unknown function (DUF718); Region: DUF718; pfam05336 479435000689 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 479435000690 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 479435000691 short chain dehydrogenase; Validated; Region: PRK08324 479435000692 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 479435000693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435000694 NAD(P) binding site [chemical binding]; other site 479435000695 active site 479435000696 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 479435000697 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 479435000698 hexamer (dimer of trimers) interface [polypeptide binding]; other site 479435000699 substrate binding site [chemical binding]; other site 479435000700 trimer interface [polypeptide binding]; other site 479435000701 Mn binding site [ion binding]; other site 479435000702 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 479435000703 N- and C-terminal domain interface [polypeptide binding]; other site 479435000704 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 479435000705 active site 479435000706 putative catalytic site [active] 479435000707 metal binding site [ion binding]; metal-binding site 479435000708 ATP binding site [chemical binding]; other site 479435000709 carbohydrate binding site [chemical binding]; other site 479435000710 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435000711 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 479435000712 DNA binding residues [nucleotide binding] 479435000713 dimerization interface [polypeptide binding]; other site 479435000714 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435000715 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 479435000716 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435000717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435000718 active site 479435000719 phosphorylation site [posttranslational modification] 479435000720 intermolecular recognition site; other site 479435000721 dimerization interface [polypeptide binding]; other site 479435000722 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435000723 DNA binding site [nucleotide binding] 479435000724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435000725 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435000726 dimerization interface [polypeptide binding]; other site 479435000727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435000728 dimer interface [polypeptide binding]; other site 479435000729 phosphorylation site [posttranslational modification] 479435000730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435000731 ATP binding site [chemical binding]; other site 479435000732 Mg2+ binding site [ion binding]; other site 479435000733 G-X-G motif; other site 479435000734 threonine dehydratase; Validated; Region: PRK08639 479435000735 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435000736 tetramer interface [polypeptide binding]; other site 479435000737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435000738 catalytic residue [active] 479435000739 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 479435000740 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 479435000741 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 479435000742 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 479435000743 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435000744 Transcriptional regulator [Transcription]; Region: LytR; COG1316 479435000745 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435000746 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435000747 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 479435000748 active site 479435000749 substrate-binding site [chemical binding]; other site 479435000750 metal-binding site [ion binding] 479435000751 GTP binding site [chemical binding]; other site 479435000752 YCII-related domain; Region: YCII; cl00999 479435000753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000754 S-adenosylmethionine binding site [chemical binding]; other site 479435000755 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435000756 nudix motif; other site 479435000757 Predicted amidohydrolase [General function prediction only]; Region: COG0388 479435000758 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 479435000759 active site 479435000760 catalytic triad [active] 479435000761 dimer interface [polypeptide binding]; other site 479435000762 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 479435000763 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 479435000764 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435000765 Protein of unknown function DUF72; Region: DUF72; pfam01904 479435000766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435000767 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435000768 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435000769 Coenzyme A binding pocket [chemical binding]; other site 479435000770 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435000771 classical (c) SDRs; Region: SDR_c; cd05233 479435000772 NAD(P) binding site [chemical binding]; other site 479435000773 active site 479435000774 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 479435000775 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 479435000776 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435000777 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 479435000778 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435000779 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435000780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435000781 binding surface 479435000782 Tetratricopeptide repeat; Region: TPR_16; pfam13432 479435000783 TPR motif; other site 479435000784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435000785 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435000786 active site 479435000787 catalytic tetrad [active] 479435000788 PhoD-like phosphatase; Region: PhoD; pfam09423 479435000789 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435000790 putative active site [active] 479435000791 putative metal binding site [ion binding]; other site 479435000792 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435000793 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435000794 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435000795 Coenzyme A binding pocket [chemical binding]; other site 479435000796 GAF domain; Region: GAF; cl17456 479435000797 PAS domain S-box; Region: sensory_box; TIGR00229 479435000798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479435000799 putative active site [active] 479435000800 heme pocket [chemical binding]; other site 479435000801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479435000802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435000803 metal binding site [ion binding]; metal-binding site 479435000804 active site 479435000805 I-site; other site 479435000806 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435000807 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435000808 Xylose isomerase [Carbohydrate transport and metabolism]; Region: XylA; cl09945 479435000809 Protein of unknown function (DUF993); Region: DUF993; pfam06187 479435000810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435000811 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435000812 Cupin domain; Region: Cupin_2; cl17218 479435000813 Uncharacterized conserved protein [Function unknown]; Region: COG2966 479435000814 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 479435000815 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 479435000816 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 479435000817 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479435000818 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 479435000819 active site 479435000820 TDP-binding site; other site 479435000821 acceptor substrate-binding pocket; other site 479435000822 homodimer interface [polypeptide binding]; other site 479435000823 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 479435000824 Lumazine binding domain; Region: Lum_binding; pfam00677 479435000825 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 479435000826 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000827 S-adenosylmethionine binding site [chemical binding]; other site 479435000828 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479435000829 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435000830 ligand binding site [chemical binding]; other site 479435000831 flexible hinge region; other site 479435000832 cyclase homology domain; Region: CHD; cd07302 479435000833 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 479435000834 nucleotidyl binding site; other site 479435000835 metal binding site [ion binding]; metal-binding site 479435000836 dimer interface [polypeptide binding]; other site 479435000837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435000838 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435000839 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435000840 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435000841 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435000842 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 479435000843 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435000844 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 479435000845 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000846 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435000847 DNA binding site [nucleotide binding] 479435000848 domain linker motif; other site 479435000849 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000850 dimerization interface [polypeptide binding]; other site 479435000851 ligand binding site [chemical binding]; other site 479435000852 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435000853 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 479435000854 substrate binding site [chemical binding]; other site 479435000855 oxyanion hole (OAH) forming residues; other site 479435000856 trimer interface [polypeptide binding]; other site 479435000857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435000858 active site 479435000859 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 479435000860 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479435000861 nucleoside/Zn binding site; other site 479435000862 dimer interface [polypeptide binding]; other site 479435000863 catalytic motif [active] 479435000864 potassium/proton antiporter; Reviewed; Region: PRK05326 479435000865 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 479435000866 TrkA-C domain; Region: TrkA_C; pfam02080 479435000867 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 479435000868 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 479435000869 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435000870 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435000871 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 479435000872 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479435000873 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435000874 metal binding site [ion binding]; metal-binding site 479435000875 active site 479435000876 I-site; other site 479435000877 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000878 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435000879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435000880 DNA binding residues [nucleotide binding] 479435000881 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435000882 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435000883 DNA binding residues [nucleotide binding] 479435000884 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435000885 DinB superfamily; Region: DinB_2; pfam12867 479435000886 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435000887 sequence-specific DNA binding site [nucleotide binding]; other site 479435000888 salt bridge; other site 479435000889 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435000890 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 479435000891 hypothetical protein; Provisional; Region: PRK08317 479435000892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435000893 S-adenosylmethionine binding site [chemical binding]; other site 479435000894 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 479435000895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000896 putative substrate translocation pore; other site 479435000897 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435000898 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435000899 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 479435000900 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435000901 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435000902 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435000903 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435000904 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435000905 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 479435000906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435000907 Histidine kinase; Region: HisKA_3; pfam07730 479435000908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435000909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435000910 active site 479435000911 phosphorylation site [posttranslational modification] 479435000912 intermolecular recognition site; other site 479435000913 dimerization interface [polypeptide binding]; other site 479435000914 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435000915 DNA binding residues [nucleotide binding] 479435000916 dimerization interface [polypeptide binding]; other site 479435000917 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435000918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435000919 non-specific DNA binding site [nucleotide binding]; other site 479435000920 salt bridge; other site 479435000921 sequence-specific DNA binding site [nucleotide binding]; other site 479435000922 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435000923 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 479435000924 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 479435000925 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 479435000926 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 479435000927 RNA binding site [nucleotide binding]; other site 479435000928 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435000929 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435000930 putative substrate translocation pore; other site 479435000931 Protein of unknown function, DUF624; Region: DUF624; cl02369 479435000932 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 479435000933 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435000934 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435000935 dimerization interface [polypeptide binding]; other site 479435000936 ligand binding site [chemical binding]; other site 479435000937 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435000938 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435000939 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435000940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000941 dimer interface [polypeptide binding]; other site 479435000942 conserved gate region; other site 479435000943 putative PBP binding loops; other site 479435000944 ABC-ATPase subunit interface; other site 479435000945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435000946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435000947 dimer interface [polypeptide binding]; other site 479435000948 conserved gate region; other site 479435000949 putative PBP binding loops; other site 479435000950 ABC-ATPase subunit interface; other site 479435000951 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435000952 putative catalytic site [active] 479435000953 putative phosphate binding site [ion binding]; other site 479435000954 putative metal binding site [ion binding]; other site 479435000955 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435000956 AAA ATPase domain; Region: AAA_16; pfam13191 479435000957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435000958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435000959 DNA binding residues [nucleotide binding] 479435000960 dimerization interface [polypeptide binding]; other site 479435000961 Domain of unknown function (DUF385); Region: DUF385; pfam04075 479435000962 Hemerythrin-like domain; Region: Hr-like; cd12108 479435000963 Fe binding site [ion binding]; other site 479435000964 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435000965 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 479435000966 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479435000967 homodimer interface [polypeptide binding]; other site 479435000968 active site 479435000969 TDP-binding site; other site 479435000970 acceptor substrate-binding pocket; other site 479435000971 Part of AAA domain; Region: AAA_19; pfam13245 479435000972 Family description; Region: UvrD_C_2; pfam13538 479435000973 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435000974 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435000975 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435000976 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 479435000977 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435000978 classical (c) SDRs; Region: SDR_c; cd05233 479435000979 NAD(P) binding site [chemical binding]; other site 479435000980 active site 479435000981 DNA binding site [nucleotide binding] 479435000982 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435000983 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435000984 AAA ATPase domain; Region: AAA_16; pfam13191 479435000985 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 479435000986 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435000987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435000988 motif II; other site 479435000989 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435000990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435000991 DNA-binding site [nucleotide binding]; DNA binding site 479435000992 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 479435000993 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435000994 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435000995 nucleotide binding site [chemical binding]; other site 479435000996 polymerase nucleotide-binding site; other site 479435000997 primase nucleotide-binding site [nucleotide binding]; other site 479435000998 DNA-binding residues [nucleotide binding]; DNA binding site 479435000999 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 479435001000 Helix-turn-helix domain; Region: HTH_17; cl17695 479435001001 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435001002 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479435001003 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435001004 active site 479435001005 DNA binding site [nucleotide binding] 479435001006 Int/Topo IB signature motif; other site 479435001007 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435001008 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 479435001009 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 479435001010 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435001011 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435001012 Coenzyme A binding pocket [chemical binding]; other site 479435001013 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 479435001014 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 479435001015 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479435001016 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 479435001017 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 479435001018 homodimer interface [polypeptide binding]; other site 479435001019 NAD binding pocket [chemical binding]; other site 479435001020 ATP binding pocket [chemical binding]; other site 479435001021 Mg binding site [ion binding]; other site 479435001022 active-site loop [active] 479435001023 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435001024 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 479435001025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435001026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435001027 active site 479435001028 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435001029 hydrophobic ligand binding site; other site 479435001030 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435001031 MarR family; Region: MarR_2; pfam12802 479435001032 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 479435001033 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 479435001034 dimer interface [polypeptide binding]; other site 479435001035 acyl-activating enzyme (AAE) consensus motif; other site 479435001036 putative active site [active] 479435001037 AMP binding site [chemical binding]; other site 479435001038 putative CoA binding site [chemical binding]; other site 479435001039 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 479435001040 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 479435001041 substrate binding site; other site 479435001042 tetramer interface; other site 479435001043 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 479435001044 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 479435001045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435001046 Walker A motif; other site 479435001047 ATP binding site [chemical binding]; other site 479435001048 Walker B motif; other site 479435001049 arginine finger; other site 479435001050 hypothetical protein; Validated; Region: PRK00153 479435001051 recombination protein RecR; Reviewed; Region: recR; PRK00076 479435001052 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435001053 RecR protein; Region: RecR; pfam02132 479435001054 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 479435001055 putative active site [active] 479435001056 putative metal-binding site [ion binding]; other site 479435001057 tetramer interface [polypeptide binding]; other site 479435001058 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 479435001059 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435001060 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 479435001061 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435001062 metal binding site 2 [ion binding]; metal-binding site 479435001063 putative DNA binding helix; other site 479435001064 metal binding site 1 [ion binding]; metal-binding site 479435001065 dimer interface [polypeptide binding]; other site 479435001066 structural Zn2+ binding site [ion binding]; other site 479435001067 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 479435001068 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 479435001069 tetramer interface [polypeptide binding]; other site 479435001070 heme binding pocket [chemical binding]; other site 479435001071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001073 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 479435001074 MFS transport protein AraJ; Provisional; Region: PRK10091 479435001075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001076 putative substrate translocation pore; other site 479435001077 DNA polymerase IV; Validated; Region: PRK03858 479435001078 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479435001079 active site 479435001080 DNA binding site [nucleotide binding] 479435001081 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435001082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001083 putative substrate translocation pore; other site 479435001084 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435001085 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435001086 DNA binding residues [nucleotide binding] 479435001087 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435001088 putative hydrophobic ligand binding site [chemical binding]; other site 479435001089 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435001090 dimerization interface [polypeptide binding]; other site 479435001091 putative DNA binding site [nucleotide binding]; other site 479435001092 putative Zn2+ binding site [ion binding]; other site 479435001093 aspartate kinase; Reviewed; Region: PRK06635 479435001094 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 479435001095 putative nucleotide binding site [chemical binding]; other site 479435001096 putative catalytic residues [active] 479435001097 putative Mg ion binding site [ion binding]; other site 479435001098 putative aspartate binding site [chemical binding]; other site 479435001099 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 479435001100 putative allosteric regulatory site; other site 479435001101 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 479435001102 putative allosteric regulatory residue; other site 479435001103 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 479435001104 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 479435001105 Predicted transcriptional regulators [Transcription]; Region: COG1378 479435001106 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 479435001107 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 479435001108 DNA binding residues [nucleotide binding] 479435001109 dimerization interface [polypeptide binding]; other site 479435001110 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 479435001111 cleavage site 479435001112 active site 479435001113 substrate binding sites [chemical binding]; other site 479435001114 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 479435001115 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 479435001116 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 479435001117 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 479435001118 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435001119 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479435001120 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 479435001121 nudix motif; other site 479435001122 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 479435001123 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479435001124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001125 NAD(P) binding site [chemical binding]; other site 479435001126 active site 479435001127 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435001128 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 479435001129 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 479435001130 putative active site [active] 479435001131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435001132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435001133 active site 479435001134 catalytic tetrad [active] 479435001135 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 479435001136 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 479435001137 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 479435001138 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 479435001139 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 479435001140 putative ligand binding site [chemical binding]; other site 479435001141 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 479435001142 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 479435001143 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435001144 putative active site [active] 479435001145 putative metal binding site [ion binding]; other site 479435001146 Yqey-like protein; Region: YqeY; pfam09424 479435001147 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 479435001148 Transglycosylase; Region: Transgly; pfam00912 479435001149 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 479435001150 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435001151 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 479435001152 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435001153 Walker A motif; other site 479435001154 ATP binding site [chemical binding]; other site 479435001155 Walker B motif; other site 479435001156 arginine finger; other site 479435001157 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 479435001158 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435001159 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 479435001160 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479435001161 DTAP/Switch II; other site 479435001162 Switch I; other site 479435001163 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435001164 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479435001165 DTAP/Switch II; other site 479435001166 Switch I; other site 479435001167 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 479435001168 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 479435001169 homotrimer interaction site [polypeptide binding]; other site 479435001170 putative active site [active] 479435001171 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435001172 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 479435001173 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479435001174 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479435001175 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435001176 ligand binding site [chemical binding]; other site 479435001177 flexible hinge region; other site 479435001178 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 479435001179 putative switch regulator; other site 479435001180 non-specific DNA interactions [nucleotide binding]; other site 479435001181 DNA binding site [nucleotide binding] 479435001182 sequence specific DNA binding site [nucleotide binding]; other site 479435001183 putative cAMP binding site [chemical binding]; other site 479435001184 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 479435001185 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479435001186 minor groove reading motif; other site 479435001187 helix-hairpin-helix signature motif; other site 479435001188 substrate binding pocket [chemical binding]; other site 479435001189 active site 479435001190 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 479435001191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 479435001192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479435001193 catalytic residues [active] 479435001194 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 479435001195 putative active site [active] 479435001196 putative CoA binding site [chemical binding]; other site 479435001197 nudix motif; other site 479435001198 metal binding site [ion binding]; metal-binding site 479435001199 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 479435001200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479435001201 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435001202 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001203 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435001204 DNA binding residues [nucleotide binding] 479435001205 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435001206 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 479435001207 pH-dependent sodium/proton antiporter; Provisional; Region: nhaA; PRK14853 479435001208 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 479435001209 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 479435001210 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 479435001211 transmembrane helices; other site 479435001212 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001213 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001214 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001215 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435001216 Walker A/P-loop; other site 479435001217 ATP binding site [chemical binding]; other site 479435001218 Q-loop/lid; other site 479435001219 ABC transporter signature motif; other site 479435001220 Walker B; other site 479435001221 D-loop; other site 479435001222 H-loop/switch region; other site 479435001223 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 479435001224 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479435001225 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479435001226 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 479435001227 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 479435001228 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 479435001229 putative dimer interface [polypeptide binding]; other site 479435001230 N-terminal domain interface [polypeptide binding]; other site 479435001231 putative substrate binding pocket (H-site) [chemical binding]; other site 479435001232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435001233 DNA-binding site [nucleotide binding]; DNA binding site 479435001234 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435001235 UTRA domain; Region: UTRA; pfam07702 479435001236 acetyl-CoA synthetase; Provisional; Region: PRK00174 479435001237 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 479435001238 active site 479435001239 CoA binding site [chemical binding]; other site 479435001240 acyl-activating enzyme (AAE) consensus motif; other site 479435001241 AMP binding site [chemical binding]; other site 479435001242 acetate binding site [chemical binding]; other site 479435001243 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435001244 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435001245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001246 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435001247 NAD(P) binding site [chemical binding]; other site 479435001248 active site 479435001249 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435001250 MarR family; Region: MarR; pfam01047 479435001251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435001252 dimerization interface [polypeptide binding]; other site 479435001253 putative DNA binding site [nucleotide binding]; other site 479435001254 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435001255 putative Zn2+ binding site [ion binding]; other site 479435001256 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 479435001257 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435001258 sugar binding site [chemical binding]; other site 479435001259 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435001260 CARDB; Region: CARDB; pfam07705 479435001261 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435001262 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 479435001263 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 479435001264 Na binding site [ion binding]; other site 479435001265 Protein of unknown function, DUF485; Region: DUF485; pfam04341 479435001266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001267 S-adenosylmethionine binding site [chemical binding]; other site 479435001268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435001269 active site 479435001270 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435001271 NAD(P) binding site [chemical binding]; other site 479435001272 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 479435001273 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 479435001274 NAD(P) binding site [chemical binding]; other site 479435001275 homodimer interface [polypeptide binding]; other site 479435001276 substrate binding site [chemical binding]; other site 479435001277 active site 479435001278 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435001279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001280 S-adenosylmethionine binding site [chemical binding]; other site 479435001281 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 479435001282 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 479435001283 inhibitor-cofactor binding pocket; inhibition site 479435001284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001285 catalytic residue [active] 479435001286 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 479435001287 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 479435001288 NAD(P) binding site [chemical binding]; other site 479435001289 homodimer interface [polypeptide binding]; other site 479435001290 substrate binding site [chemical binding]; other site 479435001291 active site 479435001292 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435001293 putative active site [active] 479435001294 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 479435001295 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 479435001296 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 479435001297 Ligand binding site; other site 479435001298 Putative Catalytic site; other site 479435001299 DXD motif; other site 479435001300 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 479435001301 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 479435001302 inhibitor-cofactor binding pocket; inhibition site 479435001303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001304 catalytic residue [active] 479435001305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435001306 active site 479435001307 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 479435001308 Putative methyltransferase; Region: Methyltransf_4; cl17290 479435001309 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 479435001310 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 479435001311 Ligand binding site; other site 479435001312 Putative Catalytic site; other site 479435001313 DXD motif; other site 479435001314 Predicted membrane protein [Function unknown]; Region: COG2246 479435001315 GtrA-like protein; Region: GtrA; pfam04138 479435001316 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479435001317 active site 479435001318 pseudaminic acid synthase; Region: PseI; TIGR03586 479435001319 NeuB family; Region: NeuB; pfam03102 479435001320 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 479435001321 NeuB binding interface [polypeptide binding]; other site 479435001322 putative substrate binding site [chemical binding]; other site 479435001323 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 479435001324 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 479435001325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001326 S-adenosylmethionine binding site [chemical binding]; other site 479435001327 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435001328 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479435001329 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435001330 acyl-activating enzyme (AAE) consensus motif; other site 479435001331 active site 479435001332 AMP binding site [chemical binding]; other site 479435001333 CoA binding site [chemical binding]; other site 479435001334 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435001335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001336 NAD(P) binding site [chemical binding]; other site 479435001337 active site 479435001338 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435001339 FAD binding domain; Region: FAD_binding_4; pfam01565 479435001340 Berberine and berberine like; Region: BBE; pfam08031 479435001341 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479435001342 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435001343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001344 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435001345 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435001346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435001348 DNA binding residues [nucleotide binding] 479435001349 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 479435001350 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435001351 HTH domain; Region: HTH_11; pfam08279 479435001352 WYL domain; Region: WYL; pfam13280 479435001353 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 479435001354 Ligand binding site; other site 479435001355 Putative Catalytic site; other site 479435001356 DXD motif; other site 479435001357 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435001358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001359 S-adenosylmethionine binding site [chemical binding]; other site 479435001360 potential frameshift: common BLAST hit: gi|241196800|ref|YP_002970355.1| dTDP-4-dehydrorhamnose 3,5-epimerase 479435001361 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 479435001362 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 479435001363 NADP binding site [chemical binding]; other site 479435001364 active site 479435001365 putative substrate binding site [chemical binding]; other site 479435001366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001367 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001368 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435001369 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435001370 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479435001371 FtsX-like permease family; Region: FtsX; pfam02687 479435001372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435001373 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435001374 Walker A/P-loop; other site 479435001375 ATP binding site [chemical binding]; other site 479435001376 Q-loop/lid; other site 479435001377 ABC transporter signature motif; other site 479435001378 Walker B; other site 479435001379 D-loop; other site 479435001380 H-loop/switch region; other site 479435001381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435001382 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435001383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435001384 active site 479435001385 phosphorylation site [posttranslational modification] 479435001386 intermolecular recognition site; other site 479435001387 dimerization interface [polypeptide binding]; other site 479435001388 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435001389 DNA binding site [nucleotide binding] 479435001390 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435001391 HAMP domain; Region: HAMP; pfam00672 479435001392 dimerization interface [polypeptide binding]; other site 479435001393 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435001394 dimer interface [polypeptide binding]; other site 479435001395 phosphorylation site [posttranslational modification] 479435001396 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435001397 ATP binding site [chemical binding]; other site 479435001398 Mg2+ binding site [ion binding]; other site 479435001399 G-X-G motif; other site 479435001400 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435001401 Coenzyme A binding pocket [chemical binding]; other site 479435001402 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435001403 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435001404 Coenzyme A binding pocket [chemical binding]; other site 479435001405 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 479435001406 arginine-tRNA ligase; Region: PLN02286 479435001407 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 479435001408 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 479435001409 active site 479435001410 HIGH motif; other site 479435001411 KMSK motif region; other site 479435001412 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 479435001413 tRNA binding surface [nucleotide binding]; other site 479435001414 anticodon binding site; other site 479435001415 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 479435001416 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435001417 active site 479435001418 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 479435001419 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 479435001420 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479435001421 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479435001422 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435001423 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435001424 Interdomain contacts; other site 479435001425 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 479435001426 putative active site [active] 479435001427 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 479435001428 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435001429 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 479435001430 DNA binding residues [nucleotide binding] 479435001431 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 479435001432 putative deacylase active site [active] 479435001433 CBD_II domain; Region: CBD_II; smart00637 479435001434 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435001435 Interdomain contacts; other site 479435001436 Cytokine receptor motif; other site 479435001437 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 479435001438 active site 479435001439 Glyco_18 domain; Region: Glyco_18; smart00636 479435001440 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 479435001441 active site 479435001442 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 479435001443 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 479435001444 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 479435001445 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 479435001446 ATP binding site [chemical binding]; other site 479435001447 Walker A motif; other site 479435001448 hexamer interface [polypeptide binding]; other site 479435001449 Walker B motif; other site 479435001450 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 479435001451 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435001452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435001453 active site 479435001454 phosphorylation site [posttranslational modification] 479435001455 intermolecular recognition site; other site 479435001456 dimerization interface [polypeptide binding]; other site 479435001457 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 479435001458 dimerization interface [polypeptide binding]; other site 479435001459 DNA binding residues [nucleotide binding] 479435001460 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 479435001461 active site 479435001462 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479435001463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435001464 Walker A/P-loop; other site 479435001465 ATP binding site [chemical binding]; other site 479435001466 Q-loop/lid; other site 479435001467 ABC transporter signature motif; other site 479435001468 Walker B; other site 479435001469 D-loop; other site 479435001470 H-loop/switch region; other site 479435001471 TOBE domain; Region: TOBE_2; pfam08402 479435001472 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435001473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435001474 dimer interface [polypeptide binding]; other site 479435001475 conserved gate region; other site 479435001476 putative PBP binding loops; other site 479435001477 ABC-ATPase subunit interface; other site 479435001478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435001479 dimer interface [polypeptide binding]; other site 479435001480 conserved gate region; other site 479435001481 putative PBP binding loops; other site 479435001482 ABC-ATPase subunit interface; other site 479435001483 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435001484 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435001485 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435001486 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 479435001487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435001488 ATP binding site [chemical binding]; other site 479435001489 putative Mg++ binding site [ion binding]; other site 479435001490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435001491 nucleotide binding region [chemical binding]; other site 479435001492 ATP-binding site [chemical binding]; other site 479435001493 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 479435001494 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435001495 anti sigma factor interaction site; other site 479435001496 regulatory phosphorylation site [posttranslational modification]; other site 479435001497 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 479435001498 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 479435001499 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001500 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479435001501 Walker A/P-loop; other site 479435001502 ATP binding site [chemical binding]; other site 479435001503 Q-loop/lid; other site 479435001504 ABC transporter signature motif; other site 479435001505 Walker B; other site 479435001506 D-loop; other site 479435001507 H-loop/switch region; other site 479435001508 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435001509 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 479435001510 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 479435001511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001512 S-adenosylmethionine binding site [chemical binding]; other site 479435001513 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479435001514 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435001515 metal binding site [ion binding]; metal-binding site 479435001516 active site 479435001517 I-site; other site 479435001518 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479435001519 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435001520 metal binding site [ion binding]; metal-binding site 479435001521 active site 479435001522 I-site; other site 479435001523 Cytochrome P450; Region: p450; cl12078 479435001524 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435001525 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 479435001526 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 479435001527 active site 479435001528 interdomain interaction site; other site 479435001529 putative metal-binding site [ion binding]; other site 479435001530 nucleotide binding site [chemical binding]; other site 479435001531 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 479435001532 domain I; other site 479435001533 DNA binding groove [nucleotide binding] 479435001534 phosphate binding site [ion binding]; other site 479435001535 domain II; other site 479435001536 domain III; other site 479435001537 nucleotide binding site [chemical binding]; other site 479435001538 catalytic site [active] 479435001539 domain IV; other site 479435001540 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479435001541 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479435001542 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479435001543 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 479435001544 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435001545 metal binding site 2 [ion binding]; metal-binding site 479435001546 putative DNA binding helix; other site 479435001547 metal binding site 1 [ion binding]; metal-binding site 479435001548 dimer interface [polypeptide binding]; other site 479435001549 structural Zn2+ binding site [ion binding]; other site 479435001550 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435001551 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 479435001552 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 479435001553 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435001554 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 479435001555 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 479435001556 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435001557 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435001558 NAD(P) binding site [chemical binding]; other site 479435001559 BioY family; Region: BioY; pfam02632 479435001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001561 putative substrate translocation pore; other site 479435001562 thymidylate kinase; Validated; Region: tmk; PRK00698 479435001563 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 479435001564 TMP-binding site; other site 479435001565 ATP-binding site [chemical binding]; other site 479435001566 DNA polymerase III subunit delta'; Validated; Region: PRK07940 479435001567 DNA polymerase III subunit delta'; Validated; Region: PRK08485 479435001568 Septum formation; Region: Septum_form; pfam13845 479435001569 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 479435001570 Septum formation; Region: Septum_form; pfam13845 479435001571 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 479435001572 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435001573 enterobactin exporter EntS; Provisional; Region: PRK10489 479435001574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001575 putative substrate translocation pore; other site 479435001576 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435001577 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 479435001578 NAD(P) binding site [chemical binding]; other site 479435001579 catalytic residues [active] 479435001580 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 479435001581 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435001582 intersubunit interface [polypeptide binding]; other site 479435001583 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435001584 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435001585 ABC-ATPase subunit interface; other site 479435001586 dimer interface [polypeptide binding]; other site 479435001587 putative PBP binding regions; other site 479435001588 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 479435001589 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435001590 ABC-ATPase subunit interface; other site 479435001591 dimer interface [polypeptide binding]; other site 479435001592 putative PBP binding regions; other site 479435001593 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435001594 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435001595 Walker A/P-loop; other site 479435001596 ATP binding site [chemical binding]; other site 479435001597 Q-loop/lid; other site 479435001598 ABC transporter signature motif; other site 479435001599 Walker B; other site 479435001600 D-loop; other site 479435001601 H-loop/switch region; other site 479435001602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435001603 DNA-binding site [nucleotide binding]; DNA binding site 479435001604 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435001605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435001606 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001607 homodimer interface [polypeptide binding]; other site 479435001608 catalytic residue [active] 479435001609 hypothetical protein; Provisional; Region: PRK08317 479435001610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001611 S-adenosylmethionine binding site [chemical binding]; other site 479435001612 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 479435001613 putative active site; other site 479435001614 putative metal binding residues [ion binding]; other site 479435001615 signature motif; other site 479435001616 putative triphosphate binding site [ion binding]; other site 479435001617 CHAD domain; Region: CHAD; pfam05235 479435001618 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 479435001619 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435001620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435001621 putative DNA binding site [nucleotide binding]; other site 479435001622 putative Zn2+ binding site [ion binding]; other site 479435001623 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 479435001624 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 479435001625 Na binding site [ion binding]; other site 479435001626 Protein of unknown function, DUF485; Region: DUF485; pfam04341 479435001627 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 479435001628 Na binding site [ion binding]; other site 479435001629 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 479435001630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435001631 active site 479435001632 phosphorylation site [posttranslational modification] 479435001633 intermolecular recognition site; other site 479435001634 dimerization interface [polypeptide binding]; other site 479435001635 LytTr DNA-binding domain; Region: LytTR; smart00850 479435001636 GAF domain; Region: GAF; cl17456 479435001637 Histidine kinase; Region: His_kinase; pfam06580 479435001638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435001639 ATP binding site [chemical binding]; other site 479435001640 Mg2+ binding site [ion binding]; other site 479435001641 G-X-G motif; other site 479435001642 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 479435001643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435001644 active site 479435001645 metal binding site [ion binding]; metal-binding site 479435001646 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435001647 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435001648 active site 479435001649 ATP binding site [chemical binding]; other site 479435001650 substrate binding site [chemical binding]; other site 479435001651 activation loop (A-loop); other site 479435001652 hypothetical protein; Provisional; Region: PRK07907 479435001653 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 479435001654 active site 479435001655 metal binding site [ion binding]; metal-binding site 479435001656 dimer interface [polypeptide binding]; other site 479435001657 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 479435001658 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 479435001659 ligand binding site [chemical binding]; other site 479435001660 homodimer interface [polypeptide binding]; other site 479435001661 NAD(P) binding site [chemical binding]; other site 479435001662 trimer interface B [polypeptide binding]; other site 479435001663 trimer interface A [polypeptide binding]; other site 479435001664 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 479435001665 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 479435001666 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 479435001667 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435001668 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435001669 DNA binding residues [nucleotide binding] 479435001670 dimerization interface [polypeptide binding]; other site 479435001671 amidophosphoribosyltransferase; Provisional; Region: PRK07847 479435001672 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 479435001673 active site 479435001674 tetramer interface [polypeptide binding]; other site 479435001675 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435001676 active site 479435001677 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 479435001678 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 479435001679 dimerization interface [polypeptide binding]; other site 479435001680 putative ATP binding site [chemical binding]; other site 479435001681 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 479435001682 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435001683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435001684 Walker A/P-loop; other site 479435001685 ATP binding site [chemical binding]; other site 479435001686 Q-loop/lid; other site 479435001687 ABC transporter signature motif; other site 479435001688 Walker B; other site 479435001689 D-loop; other site 479435001690 H-loop/switch region; other site 479435001691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435001692 Histidine kinase; Region: HisKA_3; pfam07730 479435001693 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435001694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435001695 active site 479435001696 phosphorylation site [posttranslational modification] 479435001697 intermolecular recognition site; other site 479435001698 dimerization interface [polypeptide binding]; other site 479435001699 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435001700 DNA binding residues [nucleotide binding] 479435001701 dimerization interface [polypeptide binding]; other site 479435001702 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435001703 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479435001704 NlpC/P60 family; Region: NLPC_P60; pfam00877 479435001705 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 479435001706 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435001707 tetramer interface [polypeptide binding]; other site 479435001708 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435001709 catalytic residue [active] 479435001710 YCII-related domain; Region: YCII; cl00999 479435001711 Uncharacterized conserved protein [Function unknown]; Region: COG3422 479435001712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435001713 Coenzyme A binding pocket [chemical binding]; other site 479435001714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001715 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435001716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001717 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435001718 putative substrate translocation pore; other site 479435001719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435001722 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435001723 translocation protein TolB; Provisional; Region: tolB; PRK04922 479435001724 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 479435001725 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435001726 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435001727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435001728 Coenzyme A binding pocket [chemical binding]; other site 479435001729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435001730 non-specific DNA binding site [nucleotide binding]; other site 479435001731 salt bridge; other site 479435001732 sequence-specific DNA binding site [nucleotide binding]; other site 479435001733 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435001734 catalytic core [active] 479435001735 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 479435001736 metal binding triad [ion binding]; metal-binding site 479435001737 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 479435001738 P-loop motif; other site 479435001739 ATP binding site [chemical binding]; other site 479435001740 Chloramphenicol (Cm) binding site [chemical binding]; other site 479435001741 catalytic residue [active] 479435001742 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 479435001743 methyltransferase, ATP-grasp peptide maturase system; Region: methyltr_grsp; TIGR04188 479435001744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001745 S-adenosylmethionine binding site [chemical binding]; other site 479435001746 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 479435001747 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 479435001748 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 479435001749 Ligand binding site; other site 479435001750 Putative Catalytic site; other site 479435001751 DXD motif; other site 479435001752 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479435001753 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435001754 nucleotide binding site [chemical binding]; other site 479435001755 Class I aldolases; Region: Aldolase_Class_I; cl17187 479435001756 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 479435001757 active site 479435001758 catalytic site [active] 479435001759 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 479435001760 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 479435001761 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 479435001762 dimer interface [polypeptide binding]; other site 479435001763 active site 479435001764 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435001765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435001766 nucleotide binding site [chemical binding]; other site 479435001767 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435001768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435001769 dimer interface [polypeptide binding]; other site 479435001770 conserved gate region; other site 479435001771 putative PBP binding loops; other site 479435001772 ABC-ATPase subunit interface; other site 479435001773 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435001774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435001775 dimer interface [polypeptide binding]; other site 479435001776 conserved gate region; other site 479435001777 putative PBP binding loops; other site 479435001778 ABC-ATPase subunit interface; other site 479435001779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435001780 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435001781 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435001782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435001783 DNA binding site [nucleotide binding] 479435001784 domain linker motif; other site 479435001785 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435001786 ligand binding site [chemical binding]; other site 479435001787 dimerization interface [polypeptide binding]; other site 479435001788 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 479435001789 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435001790 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435001791 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479435001792 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479435001793 Probable Catalytic site; other site 479435001794 metal-binding site 479435001795 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 479435001796 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 479435001797 putative active site [active] 479435001798 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 479435001799 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 479435001800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435001801 active site 479435001802 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 479435001803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435001804 active site 479435001805 motif I; other site 479435001806 motif II; other site 479435001807 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 479435001808 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 479435001809 putative active site [active] 479435001810 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435001811 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479435001812 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 479435001813 putative ADP-binding pocket [chemical binding]; other site 479435001814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435001815 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 479435001816 dimer interface [polypeptide binding]; other site 479435001817 active site 479435001818 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 479435001819 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479435001820 substrate binding site [chemical binding]; other site 479435001821 ATP binding site [chemical binding]; other site 479435001822 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 479435001823 active site 479435001824 nucleotide binding site [chemical binding]; other site 479435001825 HIGH motif; other site 479435001826 KMSKS motif; other site 479435001827 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479435001828 classical (c) SDRs; Region: SDR_c; cd05233 479435001829 NAD(P) binding site [chemical binding]; other site 479435001830 active site 479435001831 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 479435001832 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 479435001833 putative active site [active] 479435001834 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435001835 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 479435001836 NAD binding site [chemical binding]; other site 479435001837 putative substrate binding site 2 [chemical binding]; other site 479435001838 putative substrate binding site 1 [chemical binding]; other site 479435001839 active site 479435001840 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435001841 anti sigma factor interaction site; other site 479435001842 regulatory phosphorylation site [posttranslational modification]; other site 479435001843 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 479435001844 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435001845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435001846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435001847 NAD(P) binding site [chemical binding]; other site 479435001848 active site 479435001849 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 479435001850 A new structural DNA glycosylase; Region: AlkD_like; cd06561 479435001851 active site 479435001852 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435001853 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435001854 putative substrate translocation pore; other site 479435001855 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 479435001856 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 479435001857 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435001858 active site 479435001859 catalytic site [active] 479435001860 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 479435001861 active site triad [active] 479435001862 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 479435001863 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435001864 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435001865 AzlC protein; Region: AzlC; cl00570 479435001866 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 479435001867 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435001868 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435001869 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435001870 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435001871 DNA binding residues [nucleotide binding] 479435001872 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435001873 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435001874 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435001875 substrate binding pocket [chemical binding]; other site 479435001876 dimerization interface [polypeptide binding]; other site 479435001877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435001878 S-adenosylmethionine binding site [chemical binding]; other site 479435001879 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435001880 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 479435001881 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 479435001882 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 479435001883 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435001884 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435001885 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435001886 GAF domain; Region: GAF; pfam01590 479435001887 ANTAR domain; Region: ANTAR; pfam03861 479435001888 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 479435001889 SWIM zinc finger; Region: SWIM; pfam04434 479435001890 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435001891 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 479435001892 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 479435001893 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 479435001894 metal ion-dependent adhesion site (MIDAS); other site 479435001895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435001896 YCII-related domain; Region: YCII; cl00999 479435001897 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 479435001898 putative hydrophobic ligand binding site [chemical binding]; other site 479435001899 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435001900 TIGR03086 family protein; Region: TIGR03086 479435001901 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 479435001902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 479435001903 active site 479435001904 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435001905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435001906 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435001907 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479435001908 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 479435001909 malate synthase A; Region: malate_syn_A; TIGR01344 479435001910 active site 479435001911 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 479435001912 cleavage site 479435001913 active site 479435001914 substrate binding sites [chemical binding]; other site 479435001915 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 479435001916 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435001917 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435001918 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 479435001919 trehalose synthase; Region: treS_nterm; TIGR02456 479435001920 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 479435001921 active site 479435001922 catalytic site [active] 479435001923 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 479435001924 active site 479435001925 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 479435001926 active site 479435001927 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 479435001928 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 479435001929 NodB motif; other site 479435001930 putative active site [active] 479435001931 putative catalytic site [active] 479435001932 putative Zn binding site [ion binding]; other site 479435001933 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479435001934 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 479435001935 DXD motif; other site 479435001936 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 479435001937 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 479435001938 TGF-beta propeptide; Region: TGFb_propeptide; pfam00688 479435001939 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435001940 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 479435001941 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435001942 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 479435001943 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 479435001944 putative metal binding site [ion binding]; other site 479435001945 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435001946 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 479435001947 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 479435001948 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 479435001949 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 479435001950 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 479435001951 active site 479435001952 catalytic site [active] 479435001953 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 479435001954 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 479435001955 active site 479435001956 catalytic site [active] 479435001957 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 479435001958 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 479435001959 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 479435001960 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 479435001961 catalytic site [active] 479435001962 active site 479435001963 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 479435001964 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479435001965 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 479435001966 putative dimer interface [polypeptide binding]; other site 479435001967 Right handed beta helix region; Region: Beta_helix; pfam13229 479435001968 stage V sporulation protein K; Region: spore_V_K; TIGR02881 479435001969 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435001970 Walker A motif; other site 479435001971 ATP binding site [chemical binding]; other site 479435001972 Walker B motif; other site 479435001973 arginine finger; other site 479435001974 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 479435001975 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435001976 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435001977 DNA binding site [nucleotide binding] 479435001978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 479435001979 binding surface 479435001980 TPR motif; other site 479435001981 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435001982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435001983 active site 479435001984 phosphorylation site [posttranslational modification] 479435001985 intermolecular recognition site; other site 479435001986 dimerization interface [polypeptide binding]; other site 479435001987 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435001988 DNA binding site [nucleotide binding] 479435001989 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435001990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435001991 dimer interface [polypeptide binding]; other site 479435001992 phosphorylation site [posttranslational modification] 479435001993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435001994 ATP binding site [chemical binding]; other site 479435001995 Mg2+ binding site [ion binding]; other site 479435001996 G-X-G motif; other site 479435001997 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435001998 Interdomain contacts; other site 479435001999 Cytokine receptor motif; other site 479435002000 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435002001 Interdomain contacts; other site 479435002002 Cytokine receptor motif; other site 479435002003 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435002004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435002005 Walker A motif; other site 479435002006 ATP binding site [chemical binding]; other site 479435002007 Walker B motif; other site 479435002008 arginine finger; other site 479435002009 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435002010 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435002011 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479435002012 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479435002013 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435002014 activation loop (A-loop); other site 479435002015 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 479435002016 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 479435002017 Protein of unknown function (DUF690); Region: DUF690; cl04939 479435002018 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479435002019 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435002020 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 479435002021 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435002022 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435002023 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435002024 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435002025 active site 479435002026 catalytic residues [active] 479435002027 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575 479435002028 Penicillin amidase; Region: Penicil_amidase; pfam01804 479435002029 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 479435002030 active site 479435002031 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 479435002032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 479435002033 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479435002034 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479435002035 FAD binding pocket [chemical binding]; other site 479435002036 FAD binding motif [chemical binding]; other site 479435002037 phosphate binding motif [ion binding]; other site 479435002038 NAD binding pocket [chemical binding]; other site 479435002039 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435002040 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435002042 Coenzyme A binding pocket [chemical binding]; other site 479435002043 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 479435002044 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 479435002045 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435002046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435002047 dimer interface [polypeptide binding]; other site 479435002048 conserved gate region; other site 479435002049 putative PBP binding loops; other site 479435002050 ABC-ATPase subunit interface; other site 479435002051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435002052 dimer interface [polypeptide binding]; other site 479435002053 conserved gate region; other site 479435002054 putative PBP binding loops; other site 479435002055 ABC-ATPase subunit interface; other site 479435002056 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435002057 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435002058 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435002059 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435002060 DNA binding site [nucleotide binding] 479435002061 domain linker motif; other site 479435002062 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435002063 dimerization interface [polypeptide binding]; other site 479435002064 ligand binding site [chemical binding]; other site 479435002065 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002066 MarR family; Region: MarR_2; cl17246 479435002067 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435002068 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435002069 active site 479435002070 catalytic tetrad [active] 479435002071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435002074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435002075 active site 479435002076 catalytic tetrad [active] 479435002077 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435002078 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 479435002079 DNA binding residues [nucleotide binding] 479435002080 putative dimer interface [polypeptide binding]; other site 479435002081 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 479435002082 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435002083 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435002084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002085 putative DNA binding site [nucleotide binding]; other site 479435002086 putative Zn2+ binding site [ion binding]; other site 479435002087 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435002088 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435002089 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435002090 GAF domain; Region: GAF; pfam01590 479435002091 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435002092 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 479435002093 active site residue [active] 479435002094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435002095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435002096 non-specific DNA binding site [nucleotide binding]; other site 479435002097 salt bridge; other site 479435002098 sequence-specific DNA binding site [nucleotide binding]; other site 479435002099 HipA N-terminal domain; Region: Couple_hipA; pfam13657 479435002100 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 479435002101 HipA-like N-terminal domain; Region: HipA_N; pfam07805 479435002102 HipA-like C-terminal domain; Region: HipA_C; pfam07804 479435002103 Tetratrico peptide repeat; Region: TPR_5; pfam12688 479435002104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435002105 binding surface 479435002106 TPR motif; other site 479435002107 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 479435002108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435002109 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435002110 active site 479435002111 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 479435002112 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435002113 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435002114 Walker A/P-loop; other site 479435002115 ATP binding site [chemical binding]; other site 479435002116 Q-loop/lid; other site 479435002117 ABC transporter signature motif; other site 479435002118 Walker B; other site 479435002119 D-loop; other site 479435002120 H-loop/switch region; other site 479435002121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435002122 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435002123 Walker A/P-loop; other site 479435002124 ATP binding site [chemical binding]; other site 479435002125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435002126 ABC transporter; Region: ABC_tran_2; pfam12848 479435002127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435002128 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435002129 S-adenosylmethionine binding site [chemical binding]; other site 479435002130 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435002131 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 479435002132 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435002133 catalytic residue [active] 479435002134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435002135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435002136 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002137 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435002138 active site 479435002139 substrate binding site [chemical binding]; other site 479435002140 ATP binding site [chemical binding]; other site 479435002141 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435002142 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435002143 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 479435002144 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435002145 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435002146 Walker A/P-loop; other site 479435002147 ATP binding site [chemical binding]; other site 479435002148 Q-loop/lid; other site 479435002149 ABC transporter signature motif; other site 479435002150 Walker B; other site 479435002151 D-loop; other site 479435002152 H-loop/switch region; other site 479435002153 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 479435002154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435002155 active site 479435002156 phosphorylation site [posttranslational modification] 479435002157 intermolecular recognition site; other site 479435002158 dimerization interface [polypeptide binding]; other site 479435002159 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435002160 DNA binding residues [nucleotide binding] 479435002161 dimerization interface [polypeptide binding]; other site 479435002162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435002163 Histidine kinase; Region: HisKA_3; pfam07730 479435002164 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435002165 ATP binding site [chemical binding]; other site 479435002166 putative Mg++ binding site [ion binding]; other site 479435002167 nucleotide binding region [chemical binding]; other site 479435002168 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 479435002169 ATP-binding site [chemical binding]; other site 479435002170 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 479435002171 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435002172 ATP binding site [chemical binding]; other site 479435002173 putative Mg++ binding site [ion binding]; other site 479435002174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435002175 ATP-binding site [chemical binding]; other site 479435002176 DEAD/DEAH box helicase; Region: DEAD; pfam00270 479435002177 ATP binding site [chemical binding]; other site 479435002178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435002179 ATP-binding site [chemical binding]; other site 479435002180 PLD-like domain; Region: PLDc_2; pfam13091 479435002181 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 479435002182 putative active site [active] 479435002183 catalytic site [active] 479435002184 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 479435002185 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 479435002186 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435002187 FeS/SAM binding site; other site 479435002188 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 479435002189 Ligand Binding Site [chemical binding]; other site 479435002190 DGQHR domain; Region: DGQHR; TIGR03187 479435002191 DNA phosphorothioation-associated DGQHR protein 1; Region: DGQHR_dnd_1; TIGR04172 479435002192 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 479435002193 DNA-sulfur modification-associated; Region: DndB; cl17621 479435002194 DGQHR domain; Region: DGQHR; TIGR03187 479435002195 DGQHR domain; Region: DGQHR; TIGR03187 479435002196 Immunity protein Imm1; Region: Imm1; pfam14430 479435002197 SCP1.201-like deaminase; Region: SCP1201-deam; pfam14428 479435002198 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002199 active site 479435002200 ATP binding site [chemical binding]; other site 479435002201 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435002202 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435002203 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435002204 non-specific DNA binding site [nucleotide binding]; other site 479435002205 salt bridge; other site 479435002206 sequence-specific DNA binding site [nucleotide binding]; other site 479435002207 Alkylmercury lyase; Region: MerB; pfam03243 479435002208 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 479435002209 DNA binding residues [nucleotide binding] 479435002210 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 479435002211 dimer interface [polypeptide binding]; other site 479435002212 mercury binding site [ion binding]; other site 479435002213 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435002214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435002216 DNA binding residues [nucleotide binding] 479435002217 Putative zinc-finger; Region: zf-HC2; pfam13490 479435002218 ANTAR domain; Region: ANTAR; pfam03861 479435002219 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002220 dimerization interface [polypeptide binding]; other site 479435002221 putative DNA binding site [nucleotide binding]; other site 479435002222 putative Zn2+ binding site [ion binding]; other site 479435002223 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 479435002224 N-acetyltransferase; Region: Acetyltransf_2; cl00949 479435002225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435002226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435002227 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435002228 dimerization interface [polypeptide binding]; other site 479435002229 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435002230 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435002231 homotrimer interaction site [polypeptide binding]; other site 479435002232 putative active site [active] 479435002233 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 479435002234 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 479435002235 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435002236 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479435002237 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435002238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435002239 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435002240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435002241 DNA-binding site [nucleotide binding]; DNA binding site 479435002242 UTRA domain; Region: UTRA; pfam07702 479435002243 Predicted membrane protein [Function unknown]; Region: COG2855 479435002244 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435002245 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 479435002246 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435002247 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435002248 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 479435002249 active site 479435002250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 479435002251 putative DNA binding site [nucleotide binding]; other site 479435002252 putative Zn2+ binding site [ion binding]; other site 479435002253 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435002254 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435002255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435002256 S-adenosylmethionine binding site [chemical binding]; other site 479435002257 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435002258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 479435002259 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 479435002260 Protein of unknown function (DUF419); Region: DUF419; pfam04237 479435002261 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435002262 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435002263 active site 479435002264 phosphorylation site [posttranslational modification] 479435002265 intermolecular recognition site; other site 479435002266 dimerization interface [polypeptide binding]; other site 479435002267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435002268 DNA binding residues [nucleotide binding] 479435002269 dimerization interface [polypeptide binding]; other site 479435002270 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435002271 Histidine kinase; Region: HisKA_3; pfam07730 479435002272 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435002273 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479435002274 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148 479435002275 primary dimer interface [polypeptide binding]; other site 479435002276 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 479435002277 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 479435002278 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479435002279 active sites [active] 479435002280 tetramer interface [polypeptide binding]; other site 479435002281 PRC-barrel domain; Region: PRC; pfam05239 479435002282 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 479435002283 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 479435002284 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435002285 putative ligand binding site [chemical binding]; other site 479435002286 putative NAD binding site [chemical binding]; other site 479435002287 catalytic site [active] 479435002288 RibD C-terminal domain; Region: RibD_C; cl17279 479435002289 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 479435002290 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 479435002291 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435002292 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435002293 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435002294 NAD(P) binding site [chemical binding]; other site 479435002295 catalytic residues [active] 479435002296 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 479435002297 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 479435002298 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 479435002299 TPP-binding site [chemical binding]; other site 479435002300 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479435002301 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 479435002302 PYR/PP interface [polypeptide binding]; other site 479435002303 dimer interface [polypeptide binding]; other site 479435002304 TPP binding site [chemical binding]; other site 479435002305 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435002306 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002307 MarR family; Region: MarR_2; pfam12802 479435002308 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435002309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002310 putative substrate translocation pore; other site 479435002311 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435002312 Coenzyme A binding pocket [chemical binding]; other site 479435002313 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 479435002314 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 479435002315 potential catalytic triad [active] 479435002316 conserved cys residue [active] 479435002317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435002318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435002319 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435002320 dimerization interface [polypeptide binding]; other site 479435002321 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 479435002322 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 479435002323 putative DNA binding site [nucleotide binding]; other site 479435002324 putative homodimer interface [polypeptide binding]; other site 479435002325 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435002326 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435002327 CsbD-like; Region: CsbD; pfam05532 479435002328 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 479435002329 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 479435002330 active site 479435002331 DNA binding site [nucleotide binding] 479435002332 Int/Topo IB signature motif; other site 479435002333 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 479435002334 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435002335 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479435002336 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435002337 NAD binding site [chemical binding]; other site 479435002338 catalytic Zn binding site [ion binding]; other site 479435002339 structural Zn binding site [ion binding]; other site 479435002340 putative phosphoketolase; Provisional; Region: PRK05261 479435002341 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 479435002342 TPP-binding site; other site 479435002343 XFP C-terminal domain; Region: XFP_C; pfam09363 479435002344 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435002345 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002346 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435002347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435002348 DNA binding residues [nucleotide binding] 479435002349 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 479435002350 Fe-S cluster binding site [ion binding]; other site 479435002351 active site 479435002352 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435002353 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 479435002354 NIPSNAP; Region: NIPSNAP; pfam07978 479435002355 NIPSNAP; Region: NIPSNAP; pfam07978 479435002356 RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145 479435002357 ATP binding site [chemical binding]; other site 479435002358 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 479435002359 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 479435002360 FAD binding domain; Region: FAD_binding_2; pfam00890 479435002361 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 479435002362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002364 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 479435002365 putative active site [active] 479435002366 catalytic site [active] 479435002367 putative metal binding site [ion binding]; other site 479435002368 OsmC-like protein; Region: OsmC; cl00767 479435002369 Predicted membrane protein [Function unknown]; Region: COG4129 479435002370 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 479435002371 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435002372 Cytochrome P450; Region: p450; cl12078 479435002373 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 479435002374 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 479435002375 active site 479435002376 catalytic site [active] 479435002377 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 479435002378 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 479435002379 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 479435002380 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435002381 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435002382 dimerization interface [polypeptide binding]; other site 479435002383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435002384 dimer interface [polypeptide binding]; other site 479435002385 phosphorylation site [posttranslational modification] 479435002386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002387 ATP binding site [chemical binding]; other site 479435002388 Mg2+ binding site [ion binding]; other site 479435002389 G-X-G motif; other site 479435002390 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435002391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435002392 active site 479435002393 phosphorylation site [posttranslational modification] 479435002394 intermolecular recognition site; other site 479435002395 dimerization interface [polypeptide binding]; other site 479435002396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435002397 DNA binding site [nucleotide binding] 479435002398 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 479435002399 DctM-like transporters; Region: DctM; pfam06808 479435002400 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 479435002401 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435002402 substrate binding pocket [chemical binding]; other site 479435002403 membrane-bound complex binding site; other site 479435002404 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435002405 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435002406 active site 479435002407 catalytic tetrad [active] 479435002408 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002409 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435002410 active site 479435002411 ATP binding site [chemical binding]; other site 479435002412 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 479435002413 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479435002414 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479435002415 Moco binding site; other site 479435002416 metal coordination site [ion binding]; other site 479435002417 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 479435002418 Fasciclin domain; Region: Fasciclin; pfam02469 479435002419 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 479435002420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435002423 EamA-like transporter family; Region: EamA; pfam00892 479435002424 EamA-like transporter family; Region: EamA; pfam00892 479435002425 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002426 MarR family; Region: MarR_2; pfam12802 479435002427 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435002428 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435002429 Domain of unknown function (DUF202); Region: DUF202; cl09954 479435002430 Domain of unknown function (DUF202); Region: DUF202; cl09954 479435002431 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 479435002432 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 479435002433 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435002434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435002435 putative acyl-acceptor binding pocket; other site 479435002436 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 479435002437 ThiC-associated domain; Region: ThiC-associated; pfam13667 479435002438 ThiC family; Region: ThiC; pfam01964 479435002439 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 479435002440 RDD family; Region: RDD; pfam06271 479435002441 RDD family; Region: RDD; pfam06271 479435002442 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 479435002443 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 479435002444 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 479435002445 Walker A/P-loop; other site 479435002446 ATP binding site [chemical binding]; other site 479435002447 Q-loop/lid; other site 479435002448 ABC transporter signature motif; other site 479435002449 Walker B; other site 479435002450 D-loop; other site 479435002451 H-loop/switch region; other site 479435002452 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 479435002453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435002454 dimer interface [polypeptide binding]; other site 479435002455 conserved gate region; other site 479435002456 putative PBP binding loops; other site 479435002457 ABC-ATPase subunit interface; other site 479435002458 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 479435002459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435002460 dimer interface [polypeptide binding]; other site 479435002461 conserved gate region; other site 479435002462 putative PBP binding loops; other site 479435002463 ABC-ATPase subunit interface; other site 479435002464 PBP superfamily domain; Region: PBP_like_2; cl17296 479435002465 Bifunctional nuclease; Region: DNase-RNase; pfam02577 479435002466 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 479435002467 active site 479435002468 Ap6A binding site [chemical binding]; other site 479435002469 nudix motif; other site 479435002470 metal binding site [ion binding]; metal-binding site 479435002471 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 479435002472 catalytic core [active] 479435002473 polyphosphate kinase; Provisional; Region: PRK05443 479435002474 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 479435002475 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 479435002476 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 479435002477 putative domain interface [polypeptide binding]; other site 479435002478 putative active site [active] 479435002479 catalytic site [active] 479435002480 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 479435002481 putative domain interface [polypeptide binding]; other site 479435002482 putative active site [active] 479435002483 catalytic site [active] 479435002484 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435002485 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435002486 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435002487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002488 Coenzyme A binding pocket [chemical binding]; other site 479435002489 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435002490 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 479435002491 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 479435002492 putative active site [active] 479435002493 putative metal binding site [ion binding]; other site 479435002494 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 479435002495 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435002496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435002497 DNA binding site [nucleotide binding] 479435002498 Ubiquitin-like proteins; Region: UBQ; cl00155 479435002499 charged pocket; other site 479435002500 hydrophobic patch; other site 479435002501 hypothetical protein; Provisional; Region: PRK09256 479435002502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435002503 catalytic residues [active] 479435002504 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 479435002505 RDD family; Region: RDD; pfam06271 479435002506 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 479435002507 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 479435002508 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 479435002509 active site residue [active] 479435002510 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 479435002511 active site residue [active] 479435002512 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 479435002513 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 479435002514 dimerization interface [polypeptide binding]; other site 479435002515 putative tRNAtyr binding site [nucleotide binding]; other site 479435002516 putative active site [active] 479435002517 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 479435002518 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 479435002519 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 479435002520 heme-binding site [chemical binding]; other site 479435002521 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 479435002522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435002523 active site 479435002524 phosphorylation site [posttranslational modification] 479435002525 intermolecular recognition site; other site 479435002526 dimerization interface [polypeptide binding]; other site 479435002527 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 479435002528 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 479435002529 PAS domain; Region: PAS; smart00091 479435002530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002531 ATP binding site [chemical binding]; other site 479435002532 Mg2+ binding site [ion binding]; other site 479435002533 G-X-G motif; other site 479435002534 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 479435002535 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 479435002536 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 479435002537 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 479435002538 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479435002539 L-asparaginase II; Region: Asparaginase_II; pfam06089 479435002540 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435002541 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435002542 non-specific DNA binding site [nucleotide binding]; other site 479435002543 salt bridge; other site 479435002544 sequence-specific DNA binding site [nucleotide binding]; other site 479435002545 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 479435002546 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479435002547 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435002548 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435002549 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 479435002550 ADP-ribose binding site [chemical binding]; other site 479435002551 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435002552 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 479435002553 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 479435002554 G1 box; other site 479435002555 putative GEF interaction site [polypeptide binding]; other site 479435002556 GTP/Mg2+ binding site [chemical binding]; other site 479435002557 Switch I region; other site 479435002558 G2 box; other site 479435002559 G3 box; other site 479435002560 Switch II region; other site 479435002561 G4 box; other site 479435002562 G5 box; other site 479435002563 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 479435002564 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 479435002565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002568 malonic semialdehyde reductase; Provisional; Region: PRK10538 479435002569 NAD(P) binding site [chemical binding]; other site 479435002570 active site 479435002571 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 479435002572 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 479435002573 putative ADP-binding pocket [chemical binding]; other site 479435002574 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 479435002575 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435002576 catalytic core [active] 479435002577 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435002578 DNA binding site [nucleotide binding] 479435002579 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435002580 Predicted ATPase [General function prediction only]; Region: COG3903 479435002581 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 479435002582 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435002583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435002584 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435002585 Walker A/P-loop; other site 479435002586 ATP binding site [chemical binding]; other site 479435002587 Q-loop/lid; other site 479435002588 ABC transporter signature motif; other site 479435002589 Walker B; other site 479435002590 D-loop; other site 479435002591 H-loop/switch region; other site 479435002592 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 479435002593 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 479435002594 PhoU domain; Region: PhoU; pfam01895 479435002595 PhoU domain; Region: PhoU; pfam01895 479435002596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435002597 dimer interface [polypeptide binding]; other site 479435002598 phosphorylation site [posttranslational modification] 479435002599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002600 ATP binding site [chemical binding]; other site 479435002601 Mg2+ binding site [ion binding]; other site 479435002602 G-X-G motif; other site 479435002603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435002604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435002605 active site 479435002606 phosphorylation site [posttranslational modification] 479435002607 intermolecular recognition site; other site 479435002608 dimerization interface [polypeptide binding]; other site 479435002609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435002610 DNA binding site [nucleotide binding] 479435002611 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 479435002612 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479435002613 siderophore binding site; other site 479435002614 Protein of unknown function (DUF461); Region: DUF461; cl01071 479435002615 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 479435002616 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 479435002617 substrate binding site; other site 479435002618 dimer interface; other site 479435002619 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 479435002620 homotrimer interaction site [polypeptide binding]; other site 479435002621 zinc binding site [ion binding]; other site 479435002622 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 479435002623 N-carbamolyputrescine amidase; Region: PLN02747 479435002624 active site 479435002625 catalytic triad [active] 479435002626 dimer interface [polypeptide binding]; other site 479435002627 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435002628 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435002629 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435002630 dimerization interface [polypeptide binding]; other site 479435002631 substrate binding pocket [chemical binding]; other site 479435002632 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 479435002633 Zn binding site [ion binding]; other site 479435002634 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435002635 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435002636 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435002637 acyl-activating enzyme (AAE) consensus motif; other site 479435002638 AMP binding site [chemical binding]; other site 479435002639 active site 479435002640 CoA binding site [chemical binding]; other site 479435002641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435002642 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 479435002643 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479435002644 putative trimer interface [polypeptide binding]; other site 479435002645 putative CoA binding site [chemical binding]; other site 479435002646 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 479435002647 putative trimer interface [polypeptide binding]; other site 479435002648 putative CoA binding site [chemical binding]; other site 479435002649 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435002650 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435002651 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435002652 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435002653 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435002654 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435002655 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435002656 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 479435002657 putative active site [active] 479435002658 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435002659 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435002660 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 479435002661 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 479435002662 active site 479435002663 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435002664 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 479435002665 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435002666 active site 479435002667 HIGH motif; other site 479435002668 nucleotide binding site [chemical binding]; other site 479435002669 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479435002670 KMSKS motif; other site 479435002671 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 479435002672 tRNA binding surface [nucleotide binding]; other site 479435002673 anticodon binding site; other site 479435002674 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435002675 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 479435002676 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479435002677 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 479435002678 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435002679 putative active site [active] 479435002680 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 479435002681 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435002682 putative active site [active] 479435002683 putative metal binding site [ion binding]; other site 479435002684 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435002685 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435002686 DNA binding site [nucleotide binding] 479435002687 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435002688 NB-ARC domain; Region: NB-ARC; pfam00931 479435002689 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002690 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002691 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435002692 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435002693 active site 479435002694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002695 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435002696 NAD(P) binding site [chemical binding]; other site 479435002697 active site 479435002698 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435002699 putative active site [active] 479435002700 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435002701 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435002703 DNA binding residues [nucleotide binding] 479435002704 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 479435002705 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435002706 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435002707 DNA binding site [nucleotide binding] 479435002708 domain linker motif; other site 479435002709 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 479435002710 putative dimerization interface [polypeptide binding]; other site 479435002711 putative ligand binding site [chemical binding]; other site 479435002712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435002713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435002714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435002715 dimer interface [polypeptide binding]; other site 479435002716 conserved gate region; other site 479435002717 putative PBP binding loops; other site 479435002718 ABC-ATPase subunit interface; other site 479435002719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435002720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435002721 dimer interface [polypeptide binding]; other site 479435002722 conserved gate region; other site 479435002723 putative PBP binding loops; other site 479435002724 ABC-ATPase subunit interface; other site 479435002725 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 479435002726 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479435002727 active site 479435002728 catalytic site [active] 479435002729 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 479435002730 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479435002731 metal-binding site [ion binding] 479435002732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479435002733 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 479435002734 YtkA-like; Region: YtkA; pfam13115 479435002735 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479435002736 metal-binding site [ion binding] 479435002737 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479435002738 putative homodimer interface [polypeptide binding]; other site 479435002739 putative homotetramer interface [polypeptide binding]; other site 479435002740 putative allosteric switch controlling residues; other site 479435002741 putative metal binding site [ion binding]; other site 479435002742 putative homodimer-homodimer interface [polypeptide binding]; other site 479435002743 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435002744 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479435002745 Walker A/P-loop; other site 479435002746 ATP binding site [chemical binding]; other site 479435002747 Q-loop/lid; other site 479435002748 ABC transporter signature motif; other site 479435002749 Walker B; other site 479435002750 D-loop; other site 479435002751 H-loop/switch region; other site 479435002752 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435002753 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479435002754 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 479435002755 Walker A/P-loop; other site 479435002756 ATP binding site [chemical binding]; other site 479435002757 Q-loop/lid; other site 479435002758 ABC transporter signature motif; other site 479435002759 Walker B; other site 479435002760 D-loop; other site 479435002761 H-loop/switch region; other site 479435002762 TOBE domain; Region: TOBE_2; pfam08402 479435002763 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435002764 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435002765 DNA binding site [nucleotide binding] 479435002766 domain linker motif; other site 479435002767 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 479435002768 putative dimerization interface [polypeptide binding]; other site 479435002769 putative ligand binding site [chemical binding]; other site 479435002770 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 479435002771 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 479435002772 DNA binding residues [nucleotide binding] 479435002773 dimer interface [polypeptide binding]; other site 479435002774 [2Fe-2S] cluster binding site [ion binding]; other site 479435002775 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 479435002776 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435002777 ATP binding site [chemical binding]; other site 479435002778 Mg++ binding site [ion binding]; other site 479435002779 motif III; other site 479435002780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435002781 nucleotide binding region [chemical binding]; other site 479435002782 ATP-binding site [chemical binding]; other site 479435002783 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435002784 catalytic residue [active] 479435002785 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479435002786 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479435002787 active site 479435002788 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 479435002789 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435002790 sugar binding site [chemical binding]; other site 479435002791 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 479435002792 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479435002793 beta-galactosidase; Region: BGL; TIGR03356 479435002794 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 479435002795 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 479435002796 trimer interface [polypeptide binding]; other site 479435002797 putative metal binding site [ion binding]; other site 479435002798 intracellular protease, PfpI family; Region: PfpI; TIGR01382 479435002799 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 479435002800 proposed catalytic triad [active] 479435002801 conserved cys residue [active] 479435002802 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435002803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435002804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435002805 dimerization interface [polypeptide binding]; other site 479435002806 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479435002807 EamA-like transporter family; Region: EamA; cl17759 479435002808 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435002809 RibD C-terminal domain; Region: RibD_C; cl17279 479435002810 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435002811 AAA ATPase domain; Region: AAA_16; pfam13191 479435002812 NB-ARC domain; Region: NB-ARC; pfam00931 479435002813 TIGR02147 family protein; Region: Fsuc_second 479435002814 Predicted transcriptional regulator [Transcription]; Region: COG1959 479435002815 Transcriptional regulator; Region: Rrf2; pfam02082 479435002816 Transcriptional regulator; Region: Rrf2; cl17282 479435002817 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002818 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435002819 NAD(P) binding site [chemical binding]; other site 479435002820 active site 479435002821 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002822 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435002823 active site 479435002824 ATP binding site [chemical binding]; other site 479435002825 haloalkane dehalogenase; Provisional; Region: PRK03204 479435002826 Uncharacterized membrane protein [Function unknown]; Region: COG5427; cl02250 479435002827 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 479435002828 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435002829 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435002830 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002831 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435002832 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435002833 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435002834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002835 Coenzyme A binding pocket [chemical binding]; other site 479435002836 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435002837 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435002838 putative NAD(P) binding site [chemical binding]; other site 479435002839 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435002840 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002841 Coenzyme A binding pocket [chemical binding]; other site 479435002842 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002843 Coenzyme A binding pocket [chemical binding]; other site 479435002844 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435002845 TrkA-N domain; Region: TrkA_N; pfam02254 479435002846 TrkA-C domain; Region: TrkA_C; pfam02080 479435002847 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 479435002848 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 479435002849 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 479435002850 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 479435002851 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435002852 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435002853 short chain dehydrogenase; Provisional; Region: PRK06180 479435002854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002855 NAD(P) binding site [chemical binding]; other site 479435002856 active site 479435002857 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435002858 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 479435002859 DNA binding residues [nucleotide binding] 479435002860 putative dimer interface [polypeptide binding]; other site 479435002861 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479435002862 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435002863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435002864 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002865 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002866 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 479435002867 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435002868 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435002869 OsmC-like protein; Region: OsmC; cl00767 479435002870 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479435002871 trehalose synthase; Region: treS_nterm; TIGR02456 479435002872 active site 479435002873 catalytic site [active] 479435002874 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002875 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435002876 active site 479435002877 ATP binding site [chemical binding]; other site 479435002878 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435002879 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435002880 Coenzyme A binding pocket [chemical binding]; other site 479435002881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002882 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435002883 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 479435002884 Secretory lipase; Region: LIP; pfam03583 479435002885 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 479435002886 RibD C-terminal domain; Region: RibD_C; cl17279 479435002887 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435002888 hydrophobic ligand binding site; other site 479435002889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002890 dimerization interface [polypeptide binding]; other site 479435002891 putative DNA binding site [nucleotide binding]; other site 479435002892 putative Zn2+ binding site [ion binding]; other site 479435002893 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 479435002894 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 479435002895 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435002896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435002897 putative substrate translocation pore; other site 479435002898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435002899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435002900 non-specific DNA binding site [nucleotide binding]; other site 479435002901 salt bridge; other site 479435002902 sequence-specific DNA binding site [nucleotide binding]; other site 479435002903 Cupin domain; Region: Cupin_2; pfam07883 479435002904 putative methyltransferase; Provisional; Region: PRK14967 479435002905 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435002906 S-adenosylmethionine binding site [chemical binding]; other site 479435002907 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435002908 Erythromycin esterase; Region: Erythro_esteras; pfam05139 479435002909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002910 dimerization interface [polypeptide binding]; other site 479435002911 putative DNA binding site [nucleotide binding]; other site 479435002912 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435002913 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 479435002914 NAD(P) binding site [chemical binding]; other site 479435002915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435002916 NAD(P) binding site [chemical binding]; other site 479435002917 active site 479435002918 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435002919 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435002920 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435002921 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 479435002922 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 479435002923 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435002924 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435002925 MarR family; Region: MarR_2; pfam12802 479435002926 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 479435002927 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435002928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435002929 AAA ATPase domain; Region: AAA_16; pfam13191 479435002930 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435002931 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435002932 DNA binding residues [nucleotide binding] 479435002933 dimerization interface [polypeptide binding]; other site 479435002934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435002935 Histidine kinase; Region: HisKA_3; pfam07730 479435002936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435002937 ATP binding site [chemical binding]; other site 479435002938 Mg2+ binding site [ion binding]; other site 479435002939 G-X-G motif; other site 479435002940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435002941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435002942 active site 479435002943 phosphorylation site [posttranslational modification] 479435002944 intermolecular recognition site; other site 479435002945 dimerization interface [polypeptide binding]; other site 479435002946 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435002947 DNA binding residues [nucleotide binding] 479435002948 dimerization interface [polypeptide binding]; other site 479435002949 Phosphotransferase enzyme family; Region: APH; pfam01636 479435002950 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435002951 substrate binding site [chemical binding]; other site 479435002952 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435002953 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435002954 dimer interface [polypeptide binding]; other site 479435002955 putative PBP binding regions; other site 479435002956 ABC-ATPase subunit interface; other site 479435002957 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435002958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435002959 Walker A/P-loop; other site 479435002960 ATP binding site [chemical binding]; other site 479435002961 Q-loop/lid; other site 479435002962 ABC transporter signature motif; other site 479435002963 Walker B; other site 479435002964 D-loop; other site 479435002965 H-loop/switch region; other site 479435002966 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 479435002967 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 479435002968 putative ligand binding residues [chemical binding]; other site 479435002969 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435002970 RibD C-terminal domain; Region: RibD_C; cl17279 479435002971 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435002972 putative DNA binding site [nucleotide binding]; other site 479435002973 putative Zn2+ binding site [ion binding]; other site 479435002974 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435002975 putative hydrophobic ligand binding site [chemical binding]; other site 479435002976 GAF domain; Region: GAF; pfam01590 479435002977 GAF domain; Region: GAF_2; pfam13185 479435002978 ANTAR domain; Region: ANTAR; pfam03861 479435002979 ANTAR domain; Region: ANTAR; pfam03861 479435002980 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435002981 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435002982 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435002983 hydrophobic ligand binding site; other site 479435002984 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435002985 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435002986 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435002987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435002988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435002989 DNA binding residues [nucleotide binding] 479435002990 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 479435002991 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479435002992 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435002993 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435002994 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 479435002995 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435002996 HTH domain; Region: HTH_11; pfam08279 479435002997 WYL domain; Region: WYL; pfam13280 479435002998 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435002999 Walker A/P-loop; other site 479435003000 ATP binding site [chemical binding]; other site 479435003001 Q-loop/lid; other site 479435003002 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 479435003003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003004 ABC transporter signature motif; other site 479435003005 Walker B; other site 479435003006 D-loop; other site 479435003007 H-loop/switch region; other site 479435003008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003009 Walker A/P-loop; other site 479435003010 ATP binding site [chemical binding]; other site 479435003011 Q-loop/lid; other site 479435003012 ABC transporter signature motif; other site 479435003013 Walker B; other site 479435003014 D-loop; other site 479435003015 H-loop/switch region; other site 479435003016 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435003017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435003018 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435003019 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435003020 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 479435003021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003022 Walker A/P-loop; other site 479435003023 ATP binding site [chemical binding]; other site 479435003024 Q-loop/lid; other site 479435003025 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003026 ABC transporter signature motif; other site 479435003027 Walker B; other site 479435003028 D-loop; other site 479435003029 H-loop/switch region; other site 479435003030 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003031 Walker A/P-loop; other site 479435003032 ATP binding site [chemical binding]; other site 479435003033 Q-loop/lid; other site 479435003034 ABC transporter signature motif; other site 479435003035 Walker B; other site 479435003036 D-loop; other site 479435003037 H-loop/switch region; other site 479435003038 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435003039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003040 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435003041 DNA binding residues [nucleotide binding] 479435003042 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435003043 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435003044 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435003045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003046 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435003047 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 479435003048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435003049 ATP binding site [chemical binding]; other site 479435003050 putative Mg++ binding site [ion binding]; other site 479435003051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435003052 nucleotide binding region [chemical binding]; other site 479435003053 ATP-binding site [chemical binding]; other site 479435003054 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 479435003055 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435003056 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435003057 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479435003058 classical (c) SDRs; Region: SDR_c; cd05233 479435003059 NAD(P) binding site [chemical binding]; other site 479435003060 active site 479435003061 Clostridial binary toxin B/anthrax toxin PA; Region: Binary_toxB; pfam03495 479435003062 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435003063 active site 479435003064 substrate binding site [chemical binding]; other site 479435003065 ATP binding site [chemical binding]; other site 479435003066 Phosphotransferase enzyme family; Region: APH; pfam01636 479435003067 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 479435003068 LexA repressor; Validated; Region: PRK00215 479435003069 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 479435003070 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 479435003071 Catalytic site [active] 479435003072 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435003073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003074 NAD(P) binding site [chemical binding]; other site 479435003075 active site 479435003076 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435003077 active site 479435003078 ATP binding site [chemical binding]; other site 479435003079 substrate binding site [chemical binding]; other site 479435003080 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435003081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435003082 putative DNA binding site [nucleotide binding]; other site 479435003083 putative Zn2+ binding site [ion binding]; other site 479435003084 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479435003085 EamA-like transporter family; Region: EamA; pfam00892 479435003086 EamA-like transporter family; Region: EamA; pfam00892 479435003087 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 479435003088 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 479435003089 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479435003090 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435003091 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435003092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435003093 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003094 dimerization interface [polypeptide binding]; other site 479435003095 MOSC domain; Region: MOSC; pfam03473 479435003096 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435003097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435003098 S-adenosylmethionine binding site [chemical binding]; other site 479435003099 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435003100 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435003101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435003102 S-adenosylmethionine binding site [chemical binding]; other site 479435003103 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479435003104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435003106 NAD(P) binding site [chemical binding]; other site 479435003107 active site 479435003108 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435003109 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435003110 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 479435003111 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435003112 Coenzyme A binding pocket [chemical binding]; other site 479435003113 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 479435003114 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 479435003115 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 479435003116 NAD binding site [chemical binding]; other site 479435003117 sugar binding site [chemical binding]; other site 479435003118 divalent metal binding site [ion binding]; other site 479435003119 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435003120 dimer interface [polypeptide binding]; other site 479435003121 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435003122 dimerization interface [polypeptide binding]; other site 479435003123 putative DNA binding site [nucleotide binding]; other site 479435003124 putative Zn2+ binding site [ion binding]; other site 479435003125 D-allose kinase; Provisional; Region: PRK09698 479435003126 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435003127 nucleotide binding site [chemical binding]; other site 479435003128 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435003129 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435003130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003131 Walker A/P-loop; other site 479435003132 ATP binding site [chemical binding]; other site 479435003133 Q-loop/lid; other site 479435003134 ABC transporter signature motif; other site 479435003135 Walker B; other site 479435003136 D-loop; other site 479435003137 H-loop/switch region; other site 479435003138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435003139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435003140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003141 Walker A/P-loop; other site 479435003142 ATP binding site [chemical binding]; other site 479435003143 Q-loop/lid; other site 479435003144 ABC transporter signature motif; other site 479435003145 Walker B; other site 479435003146 D-loop; other site 479435003147 H-loop/switch region; other site 479435003148 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 479435003149 ligand binding site [chemical binding]; other site 479435003150 active site 479435003151 UGI interface [polypeptide binding]; other site 479435003152 catalytic site [active] 479435003153 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 479435003154 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 479435003155 ligand binding site [chemical binding]; other site 479435003156 RibD C-terminal domain; Region: RibD_C; cl17279 479435003157 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435003158 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435003159 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435003160 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435003161 Coenzyme A binding pocket [chemical binding]; other site 479435003162 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 479435003163 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 479435003164 Survival protein SurE; Region: SurE; cl00448 479435003165 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 479435003166 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479435003167 substrate binding site [chemical binding]; other site 479435003168 ATP binding site [chemical binding]; other site 479435003169 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 479435003170 IHF dimer interface [polypeptide binding]; other site 479435003171 IHF - DNA interface [nucleotide binding]; other site 479435003172 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 479435003173 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 479435003174 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 479435003175 active site 479435003176 Zn binding site [ion binding]; other site 479435003177 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 479435003178 proline aminopeptidase P II; Provisional; Region: PRK10879 479435003179 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 479435003180 active site 479435003181 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 479435003182 tetramerization interface [polypeptide binding]; other site 479435003183 active site 479435003184 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435003185 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479435003186 nucleotide binding site [chemical binding]; other site 479435003187 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 479435003188 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 479435003189 active site 479435003190 homotetramer interface [polypeptide binding]; other site 479435003191 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435003192 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435003193 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435003194 Amidase; Region: Amidase; cl11426 479435003195 amidase; Provisional; Region: PRK08137 479435003196 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 479435003197 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 479435003198 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 479435003199 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479435003200 minor groove reading motif; other site 479435003201 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435003202 helix-hairpin-helix signature motif; other site 479435003203 substrate binding pocket [chemical binding]; other site 479435003204 active site 479435003205 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 479435003206 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435003207 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435003208 conserved cys residue [active] 479435003209 threonine synthase; Validated; Region: PRK07591 479435003210 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 479435003211 homodimer interface [polypeptide binding]; other site 479435003212 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435003213 catalytic residue [active] 479435003214 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479435003215 MoaE interaction surface [polypeptide binding]; other site 479435003216 MoeB interaction surface [polypeptide binding]; other site 479435003217 thiocarboxylated glycine; other site 479435003218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435003219 Coenzyme A binding pocket [chemical binding]; other site 479435003220 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435003221 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 479435003222 putative NAD(P) binding site [chemical binding]; other site 479435003223 catalytic Zn binding site [ion binding]; other site 479435003224 structural Zn binding site [ion binding]; other site 479435003225 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435003226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003227 putative substrate translocation pore; other site 479435003228 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479435003229 DNA-binding site [nucleotide binding]; DNA binding site 479435003230 RNA-binding motif; other site 479435003231 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435003232 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 479435003233 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435003234 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435003235 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003236 putative substrate translocation pore; other site 479435003237 PspC domain; Region: PspC; pfam04024 479435003238 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 479435003239 PspC domain; Region: PspC; pfam04024 479435003240 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435003241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435003242 ATP binding site [chemical binding]; other site 479435003243 Mg2+ binding site [ion binding]; other site 479435003244 G-X-G motif; other site 479435003245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435003247 active site 479435003248 phosphorylation site [posttranslational modification] 479435003249 intermolecular recognition site; other site 479435003250 dimerization interface [polypeptide binding]; other site 479435003251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435003252 DNA binding residues [nucleotide binding] 479435003253 dimerization interface [polypeptide binding]; other site 479435003254 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 479435003255 trimer interface [polypeptide binding]; other site 479435003256 active site 479435003257 G bulge; other site 479435003258 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435003259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435003260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003261 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 479435003262 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435003263 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 479435003264 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 479435003265 DNA binding residues [nucleotide binding] 479435003266 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 479435003267 dimer interface [polypeptide binding]; other site 479435003268 mercury binding site [ion binding]; other site 479435003269 hypothetical protein; Provisional; Region: PRK02237 479435003270 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 479435003271 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435003272 oligomer interface [polypeptide binding]; other site 479435003273 active site residues [active] 479435003274 Clp protease; Region: CLP_protease; pfam00574 479435003275 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435003276 oligomer interface [polypeptide binding]; other site 479435003277 active site residues [active] 479435003278 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435003279 conserved cys residue [active] 479435003280 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435003281 homotrimer interaction site [polypeptide binding]; other site 479435003282 putative active site [active] 479435003283 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435003284 HTH domain; Region: HTH_11; pfam08279 479435003285 WYL domain; Region: WYL; pfam13280 479435003286 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435003287 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435003288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003289 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 479435003290 NAD(P) binding site [chemical binding]; other site 479435003291 active site 479435003292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435003293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435003294 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435003295 dimerization interface [polypeptide binding]; other site 479435003296 substrate binding pocket [chemical binding]; other site 479435003297 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 479435003298 Part of AAA domain; Region: AAA_19; pfam13245 479435003299 Family description; Region: UvrD_C_2; pfam13538 479435003300 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435003301 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435003302 Flagellar transcriptional activator (FlhD); Region: FlhD; cl05012 479435003303 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435003304 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 479435003305 nucleophilic elbow; other site 479435003306 catalytic triad; other site 479435003307 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 479435003308 B12 binding site [chemical binding]; other site 479435003309 cobalt ligand [ion binding]; other site 479435003310 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435003311 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435003312 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003313 dimer interface [polypeptide binding]; other site 479435003314 conserved gate region; other site 479435003315 putative PBP binding loops; other site 479435003316 ABC-ATPase subunit interface; other site 479435003317 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003319 dimer interface [polypeptide binding]; other site 479435003320 conserved gate region; other site 479435003321 putative PBP binding loops; other site 479435003322 ABC-ATPase subunit interface; other site 479435003323 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479435003324 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435003325 active site 479435003326 catalytic site [active] 479435003327 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 479435003328 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 479435003329 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 479435003330 CoA-ligase; Region: Ligase_CoA; pfam00549 479435003331 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 479435003332 CoA binding domain; Region: CoA_binding; smart00881 479435003333 CoA-ligase; Region: Ligase_CoA; pfam00549 479435003334 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 479435003335 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 479435003336 active site 479435003337 substrate binding site [chemical binding]; other site 479435003338 cosubstrate binding site; other site 479435003339 catalytic site [active] 479435003340 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 479435003341 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 479435003342 purine monophosphate binding site [chemical binding]; other site 479435003343 dimer interface [polypeptide binding]; other site 479435003344 putative catalytic residues [active] 479435003345 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 479435003346 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 479435003347 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435003348 Glyco_18 domain; Region: Glyco_18; smart00636 479435003349 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 479435003350 active site 479435003351 Phosphotransferase enzyme family; Region: APH; pfam01636 479435003352 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 479435003353 active site 479435003354 ATP binding site [chemical binding]; other site 479435003355 antibiotic binding site [chemical binding]; other site 479435003356 Pirin-related protein [General function prediction only]; Region: COG1741 479435003357 Pirin; Region: Pirin; pfam02678 479435003358 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 479435003359 MMPL family; Region: MMPL; pfam03176 479435003360 MMPL family; Region: MMPL; pfam03176 479435003361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435003362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003363 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435003364 RHS Repeat; Region: RHS_repeat; pfam05593 479435003365 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435003366 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 479435003367 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 479435003368 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 479435003369 homodimer interface [polypeptide binding]; other site 479435003370 NADP binding site [chemical binding]; other site 479435003371 substrate binding site [chemical binding]; other site 479435003372 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 479435003373 malate dehydrogenase; Provisional; Region: PRK05442 479435003374 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 479435003375 NAD(P) binding site [chemical binding]; other site 479435003376 dimer interface [polypeptide binding]; other site 479435003377 malate binding site [chemical binding]; other site 479435003378 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 479435003379 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 479435003380 putative active site [active] 479435003381 catalytic site [active] 479435003382 putative metal binding site [ion binding]; other site 479435003383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435003384 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 479435003385 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 479435003386 MOSC domain; Region: MOSC; pfam03473 479435003387 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479435003388 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 479435003389 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435003390 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435003391 conserved cys residue [active] 479435003392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435003393 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 479435003394 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 479435003395 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 479435003396 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 479435003397 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 479435003398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003399 NAD(P) binding site [chemical binding]; other site 479435003400 active site 479435003401 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435003402 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435003403 Coenzyme A binding pocket [chemical binding]; other site 479435003404 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435003405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435003406 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435003407 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435003408 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435003409 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 479435003410 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479435003411 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 479435003412 galactokinase; Provisional; Region: PRK00555 479435003413 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 479435003414 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 479435003415 dimer interface [polypeptide binding]; other site 479435003416 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 479435003417 active site 479435003418 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479435003419 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435003420 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435003421 Transporter associated domain; Region: CorC_HlyC; smart01091 479435003422 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435003423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435003424 dimerization interface [polypeptide binding]; other site 479435003425 putative DNA binding site [nucleotide binding]; other site 479435003426 putative Zn2+ binding site [ion binding]; other site 479435003427 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435003428 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435003429 active site 479435003430 ATP binding site [chemical binding]; other site 479435003431 substrate binding site [chemical binding]; other site 479435003432 activation loop (A-loop); other site 479435003433 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435003434 YCII-related domain; Region: YCII; cl00999 479435003435 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435003436 Protein of unknown function (DUF805); Region: DUF805; pfam05656 479435003437 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435003438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435003440 active site 479435003441 phosphorylation site [posttranslational modification] 479435003442 intermolecular recognition site; other site 479435003443 dimerization interface [polypeptide binding]; other site 479435003444 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435003445 DNA binding residues [nucleotide binding] 479435003446 dimerization interface [polypeptide binding]; other site 479435003447 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 479435003448 hypothetical protein; Provisional; Region: PRK02947 479435003449 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 479435003450 putative active site [active] 479435003451 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 479435003452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435003453 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435003454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003455 dimer interface [polypeptide binding]; other site 479435003456 conserved gate region; other site 479435003457 putative PBP binding loops; other site 479435003458 ABC-ATPase subunit interface; other site 479435003459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003461 dimer interface [polypeptide binding]; other site 479435003462 conserved gate region; other site 479435003463 putative PBP binding loops; other site 479435003464 ABC-ATPase subunit interface; other site 479435003465 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 479435003466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435003467 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435003468 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 479435003469 siderophore binding site; other site 479435003470 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 479435003471 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 479435003472 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 479435003473 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 479435003474 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 479435003475 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 479435003476 active site 479435003477 ethanolamine permease; Region: 2A0305; TIGR00908 479435003478 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 479435003479 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479435003480 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479435003481 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 479435003482 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 479435003483 catalytic triad [active] 479435003484 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435003485 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435003486 NAD(P) binding site [chemical binding]; other site 479435003487 catalytic residues [active] 479435003488 short chain dehydrogenase; Provisional; Region: PRK06057 479435003489 classical (c) SDRs; Region: SDR_c; cd05233 479435003490 NAD(P) binding site [chemical binding]; other site 479435003491 active site 479435003492 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435003493 DNA-binding site [nucleotide binding]; DNA binding site 479435003494 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435003495 FCD domain; Region: FCD; pfam07729 479435003496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435003497 Walker A motif; other site 479435003498 ATP binding site [chemical binding]; other site 479435003499 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003500 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435003501 DNA binding residues [nucleotide binding] 479435003502 dimerization interface [polypeptide binding]; other site 479435003503 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 479435003504 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435003505 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435003506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435003507 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 479435003508 SxDxEG motif; other site 479435003509 active site 479435003510 metal binding site [ion binding]; metal-binding site 479435003511 homopentamer interface [polypeptide binding]; other site 479435003512 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 479435003513 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 479435003514 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 479435003515 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 479435003516 L-aspartate oxidase; Provisional; Region: PRK06175 479435003517 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 479435003518 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 479435003519 putative Iron-sulfur protein interface [polypeptide binding]; other site 479435003520 putative proximal heme binding site [chemical binding]; other site 479435003521 putative SdhC-like subunit interface [polypeptide binding]; other site 479435003522 putative distal heme binding site [chemical binding]; other site 479435003523 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 479435003524 putative Iron-sulfur protein interface [polypeptide binding]; other site 479435003525 putative proximal heme binding site [chemical binding]; other site 479435003526 putative SdhD-like interface [polypeptide binding]; other site 479435003527 putative distal heme binding site [chemical binding]; other site 479435003528 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435003529 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 479435003530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435003531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435003532 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 479435003533 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 479435003534 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 479435003535 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 479435003536 metal binding site [ion binding]; metal-binding site 479435003537 putative dimer interface [polypeptide binding]; other site 479435003538 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435003539 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 479435003540 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 479435003541 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 479435003542 ligand binding site [chemical binding]; other site 479435003543 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 479435003544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435003545 Walker A/P-loop; other site 479435003546 ATP binding site [chemical binding]; other site 479435003547 Q-loop/lid; other site 479435003548 ABC transporter signature motif; other site 479435003549 Walker B; other site 479435003550 D-loop; other site 479435003551 H-loop/switch region; other site 479435003552 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479435003553 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435003554 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479435003555 TM-ABC transporter signature motif; other site 479435003556 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 479435003557 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 479435003558 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435003559 TM-ABC transporter signature motif; other site 479435003560 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 479435003561 active site 479435003562 catalytic motif [active] 479435003563 Zn binding site [ion binding]; other site 479435003564 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 479435003565 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 479435003566 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 479435003567 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 479435003568 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479435003569 active site 479435003570 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435003571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435003572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003573 dimer interface [polypeptide binding]; other site 479435003574 conserved gate region; other site 479435003575 putative PBP binding loops; other site 479435003576 ABC-ATPase subunit interface; other site 479435003577 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003579 dimer interface [polypeptide binding]; other site 479435003580 conserved gate region; other site 479435003581 putative PBP binding loops; other site 479435003582 ABC-ATPase subunit interface; other site 479435003583 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479435003584 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479435003585 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479435003586 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 479435003587 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 479435003588 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435003589 nucleotide binding site [chemical binding]; other site 479435003590 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435003591 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435003592 ATP binding site [chemical binding]; other site 479435003593 Mg2+ binding site [ion binding]; other site 479435003594 G-X-G motif; other site 479435003595 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435003597 active site 479435003598 phosphorylation site [posttranslational modification] 479435003599 intermolecular recognition site; other site 479435003600 dimerization interface [polypeptide binding]; other site 479435003601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435003602 DNA binding residues [nucleotide binding] 479435003603 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435003604 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 479435003605 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435003606 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435003607 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003608 dimerization interface [polypeptide binding]; other site 479435003609 PRC-barrel domain; Region: PRC; pfam05239 479435003610 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479435003611 von Willebrand factor type A domain; Region: VWA_2; pfam13519 479435003612 metal ion-dependent adhesion site (MIDAS); other site 479435003613 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435003614 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435003615 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435003616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435003617 Walker A motif; other site 479435003618 ATP binding site [chemical binding]; other site 479435003619 Walker B motif; other site 479435003620 arginine finger; other site 479435003621 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435003622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435003623 active site 479435003624 phosphorylation site [posttranslational modification] 479435003625 intermolecular recognition site; other site 479435003626 dimerization interface [polypeptide binding]; other site 479435003627 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435003628 DNA binding site [nucleotide binding] 479435003629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435003630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435003631 dimerization interface [polypeptide binding]; other site 479435003632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435003633 dimer interface [polypeptide binding]; other site 479435003634 phosphorylation site [posttranslational modification] 479435003635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435003636 ATP binding site [chemical binding]; other site 479435003637 Mg2+ binding site [ion binding]; other site 479435003638 G-X-G motif; other site 479435003639 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479435003640 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479435003641 Zn binding site [ion binding]; other site 479435003642 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 479435003643 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435003644 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003645 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435003646 DNA binding residues [nucleotide binding] 479435003647 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 479435003648 putative dimer interface [polypeptide binding]; other site 479435003649 catalytic triad [active] 479435003650 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435003651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435003652 S-adenosylmethionine binding site [chemical binding]; other site 479435003653 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435003654 NAD(P) binding site [chemical binding]; other site 479435003655 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 479435003656 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435003657 NAD(P) binding site [chemical binding]; other site 479435003658 catalytic residues [active] 479435003659 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 479435003660 intersubunit interface [polypeptide binding]; other site 479435003661 active site 479435003662 catalytic residue [active] 479435003663 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435003664 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 479435003665 Putative esterase; Region: Esterase; pfam00756 479435003666 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435003667 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 479435003668 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 479435003669 active site 479435003670 substrate binding site [chemical binding]; other site 479435003671 metal binding site [ion binding]; metal-binding site 479435003672 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 479435003673 putative active site pocket [active] 479435003674 dimerization interface [polypeptide binding]; other site 479435003675 putative catalytic residue [active] 479435003676 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 479435003677 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435003678 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435003679 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435003680 Phosphotransferase enzyme family; Region: APH; pfam01636 479435003681 active site 479435003682 ATP binding site [chemical binding]; other site 479435003683 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 479435003684 amidase catalytic site [active] 479435003685 Zn binding residues [ion binding]; other site 479435003686 substrate binding site [chemical binding]; other site 479435003687 LGFP repeat; Region: LGFP; pfam08310 479435003688 Stage II sporulation protein; Region: SpoIID; pfam08486 479435003689 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 479435003690 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435003691 active site 479435003692 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 479435003693 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003694 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435003695 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435003696 DNA binding residues [nucleotide binding] 479435003697 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 479435003698 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435003699 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 479435003700 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 479435003701 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479435003702 carboxyltransferase (CT) interaction site; other site 479435003703 biotinylation site [posttranslational modification]; other site 479435003704 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 479435003705 Strictosidine synthase; Region: Str_synth; pfam03088 479435003706 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435003707 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 479435003708 MMPL family; Region: MMPL; pfam03176 479435003709 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 479435003710 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 479435003711 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 479435003712 [4Fe-4S] binding site [ion binding]; other site 479435003713 molybdopterin cofactor binding site; other site 479435003714 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 479435003715 molybdopterin cofactor binding site; other site 479435003716 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435003717 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 479435003718 nitrite reductase subunit NirD; Provisional; Region: PRK14989 479435003719 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 479435003720 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 479435003721 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435003722 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 479435003723 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 479435003724 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 479435003725 active site 479435003726 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435003727 DNA binding site [nucleotide binding] 479435003728 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 479435003729 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 479435003730 putative active site [active] 479435003731 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 479435003732 active site 479435003733 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435003734 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 479435003735 DNA binding residues [nucleotide binding] 479435003736 putative dimer interface [polypeptide binding]; other site 479435003737 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435003738 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435003739 active site 479435003740 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479435003741 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 479435003742 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 479435003743 Phosphotransferase enzyme family; Region: APH; pfam01636 479435003744 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435003745 active site 479435003746 ATP binding site [chemical binding]; other site 479435003747 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 479435003748 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 479435003749 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 479435003750 hypothetical protein; Provisional; Region: PRK01346 479435003751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435003752 Coenzyme A binding pocket [chemical binding]; other site 479435003753 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435003754 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435003755 ATP binding site [chemical binding]; other site 479435003756 Walker A motif; other site 479435003757 Walker B motif; other site 479435003758 arginine finger; other site 479435003759 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435003760 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435003761 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435003762 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435003763 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003764 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435003765 putative substrate translocation pore; other site 479435003766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003767 Protein of unknown function (DUF419); Region: DUF419; pfam04237 479435003768 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435003769 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 479435003770 Maf-like protein; Region: Maf; pfam02545 479435003771 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 479435003772 active site 479435003773 dimer interface [polypeptide binding]; other site 479435003774 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435003775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435003776 S-adenosylmethionine binding site [chemical binding]; other site 479435003777 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479435003778 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 479435003779 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 479435003780 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 479435003781 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 479435003782 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 479435003783 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 479435003784 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 479435003785 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 479435003786 Bacterial PH domain; Region: DUF304; pfam03703 479435003787 Predicted membrane protein [Function unknown]; Region: COG2246 479435003788 GtrA-like protein; Region: GtrA; pfam04138 479435003789 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 479435003790 ATP-grasp domain; Region: ATP-grasp; pfam02222 479435003791 AIR carboxylase; Region: AIRC; pfam00731 479435003792 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435003793 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 479435003794 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 479435003795 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 479435003796 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435003797 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435003798 active site 479435003799 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435003800 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435003801 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479435003802 active site 479435003803 catalytic triad [active] 479435003804 oxyanion hole [active] 479435003805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435003806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479435003807 ANTAR domain; Region: ANTAR; pfam03861 479435003808 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435003809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435003810 DNA binding residues [nucleotide binding] 479435003811 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 479435003812 putative active site [active] 479435003813 catalytic site [active] 479435003814 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435003815 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435003816 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435003817 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435003818 DNA binding site [nucleotide binding] 479435003819 domain linker motif; other site 479435003820 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435003821 ligand binding site [chemical binding]; other site 479435003822 dimerization interface [polypeptide binding]; other site 479435003823 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 479435003824 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003826 dimer interface [polypeptide binding]; other site 479435003827 conserved gate region; other site 479435003828 putative PBP binding loops; other site 479435003829 ABC-ATPase subunit interface; other site 479435003830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003831 dimer interface [polypeptide binding]; other site 479435003832 conserved gate region; other site 479435003833 putative PBP binding loops; other site 479435003834 ABC-ATPase subunit interface; other site 479435003835 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435003836 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 479435003837 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479435003838 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435003839 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435003840 DNA binding site [nucleotide binding] 479435003841 domain linker motif; other site 479435003842 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435003843 dimerization interface [polypeptide binding]; other site 479435003844 ligand binding site [chemical binding]; other site 479435003845 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435003846 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435003847 amidase; Provisional; Region: PRK06170 479435003848 Amidase; Region: Amidase; pfam01425 479435003849 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435003850 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435003851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003852 NAD(P) binding site [chemical binding]; other site 479435003853 active site 479435003854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435003855 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003856 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 479435003857 classical (c) SDRs; Region: SDR_c; cd05233 479435003858 NAD(P) binding site [chemical binding]; other site 479435003859 active site 479435003860 Disaggregatase related repeat; Region: Disaggr_repeat; pfam06848 479435003861 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 479435003862 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435003863 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435003864 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 479435003865 protein-splicing catalytic site; other site 479435003866 thioester formation/cholesterol transfer; other site 479435003867 Pretoxin HINT domain; Region: PT-HINT; pfam07591 479435003868 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 479435003869 Fasciclin domain; Region: Fasciclin; pfam02469 479435003870 putative anti-sigmaE protein; Provisional; Region: PRK13920 479435003871 Putative zinc-finger; Region: zf-HC2; pfam13490 479435003872 Anti-sigma-K factor rskA; Region: RskA; pfam10099 479435003873 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 479435003874 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435003875 putative active site [active] 479435003876 putative metal binding site [ion binding]; other site 479435003877 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479435003878 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435003879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435003880 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435003881 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435003882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003883 NAD(P) binding site [chemical binding]; other site 479435003884 active site 479435003885 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003886 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435003887 NAD(P) binding site [chemical binding]; other site 479435003888 active site 479435003889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435003890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435003891 DNA binding residues [nucleotide binding] 479435003892 dimerization interface [polypeptide binding]; other site 479435003893 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 479435003894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435003895 salt bridge; other site 479435003896 non-specific DNA binding site [nucleotide binding]; other site 479435003897 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435003898 sequence-specific DNA binding site [nucleotide binding]; other site 479435003899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435003900 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435003901 salt bridge; other site 479435003902 non-specific DNA binding site [nucleotide binding]; other site 479435003903 sequence-specific DNA binding site [nucleotide binding]; other site 479435003904 short chain dehydrogenase; Provisional; Region: PRK06180 479435003905 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435003906 NADP binding site [chemical binding]; other site 479435003907 active site 479435003908 steroid binding site; other site 479435003909 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479435003910 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003911 NAD(P) binding site [chemical binding]; other site 479435003912 active site 479435003913 hypothetical protein; Provisional; Region: PRK08204 479435003914 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435003915 active site 479435003916 short chain dehydrogenase; Provisional; Region: PRK06197 479435003917 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435003918 NAD(P) binding site [chemical binding]; other site 479435003919 active site 479435003920 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 479435003921 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 479435003922 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435003923 sugar binding site [chemical binding]; other site 479435003924 Alginate lyase; Region: Alginate_lyase2; pfam08787 479435003925 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435003926 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435003927 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435003928 dimerization interface [polypeptide binding]; other site 479435003929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435003930 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435003931 putative metal binding site [ion binding]; other site 479435003932 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479435003933 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 479435003934 active site 479435003935 catalytic site [active] 479435003936 Predicted acetyltransferase [General function prediction only]; Region: COG5628 479435003937 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435003938 dimerization interface [polypeptide binding]; other site 479435003939 putative Zn2+ binding site [ion binding]; other site 479435003940 putative DNA binding site [nucleotide binding]; other site 479435003941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003942 dimer interface [polypeptide binding]; other site 479435003943 conserved gate region; other site 479435003944 putative PBP binding loops; other site 479435003945 ABC-ATPase subunit interface; other site 479435003946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435003947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435003948 dimer interface [polypeptide binding]; other site 479435003949 conserved gate region; other site 479435003950 putative PBP binding loops; other site 479435003951 ABC-ATPase subunit interface; other site 479435003952 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 479435003953 Ca binding site [ion binding]; other site 479435003954 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435003955 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435003956 Melibiase; Region: Melibiase; pfam02065 479435003957 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 479435003958 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435003959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435003960 nucleotide binding site [chemical binding]; other site 479435003961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435003962 S-adenosylmethionine binding site [chemical binding]; other site 479435003963 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435003964 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435003965 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435003966 Protein of unknown function (DUF419); Region: DUF419; cl15265 479435003967 FO synthase subunit 1; Reviewed; Region: cofG; PRK06245 479435003968 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 479435003969 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479435003970 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435003971 motif II; other site 479435003972 Domain of unknown function (DUF305); Region: DUF305; pfam03713 479435003973 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435003974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435003975 putative substrate translocation pore; other site 479435003976 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 479435003977 putative homodimer interface [polypeptide binding]; other site 479435003978 putative homotetramer interface [polypeptide binding]; other site 479435003979 putative allosteric switch controlling residues; other site 479435003980 putative metal binding site [ion binding]; other site 479435003981 putative homodimer-homodimer interface [polypeptide binding]; other site 479435003982 hypothetical protein; Provisional; Region: PRK06834 479435003983 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479435003984 RibD C-terminal domain; Region: RibD_C; cl17279 479435003985 CAAX protease self-immunity; Region: Abi; pfam02517 479435003986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435003987 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 479435003988 active site 479435003989 DNA binding site [nucleotide binding] 479435003990 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 479435003991 DNA binding site [nucleotide binding] 479435003992 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435003993 salt bridge; other site 479435003994 non-specific DNA binding site [nucleotide binding]; other site 479435003995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435003996 sequence-specific DNA binding site [nucleotide binding]; other site 479435003997 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 479435003998 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435003999 catalytic Zn binding site [ion binding]; other site 479435004000 NAD(P) binding site [chemical binding]; other site 479435004001 structural Zn binding site [ion binding]; other site 479435004002 Uncharacterized conserved protein [Function unknown]; Region: COG4925 479435004003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004004 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 479435004005 putative substrate translocation pore; other site 479435004006 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 479435004007 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 479435004008 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435004009 Transcriptional regulator PadR-like family; Region: PadR; cl17335 479435004010 short chain dehydrogenase; Validated; Region: PRK06182 479435004011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004012 NAD(P) binding site [chemical binding]; other site 479435004013 active site 479435004014 Hemerythrin-like domain; Region: Hr-like; cd12108 479435004015 Fe binding site [ion binding]; other site 479435004016 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435004017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435004018 Coenzyme A binding pocket [chemical binding]; other site 479435004019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004020 putative substrate translocation pore; other site 479435004021 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004022 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004024 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435004025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435004026 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435004027 hydrophobic ligand binding site; other site 479435004028 Helix-turn-helix domain; Region: HTH_31; pfam13560 479435004029 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435004030 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435004031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435004032 non-specific DNA binding site [nucleotide binding]; other site 479435004033 salt bridge; other site 479435004034 sequence-specific DNA binding site [nucleotide binding]; other site 479435004035 Cupin domain; Region: Cupin_2; cl17218 479435004036 AzlC protein; Region: AzlC; pfam03591 479435004037 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 479435004038 tyrosine kinase; Provisional; Region: PRK11519 479435004039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435004040 S-adenosylmethionine binding site [chemical binding]; other site 479435004041 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479435004042 Transcriptional regulator [Transcription]; Region: LytR; COG1316 479435004043 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479435004044 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 479435004045 Ligand binding site; other site 479435004046 YCII-related domain; Region: YCII; cl00999 479435004047 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435004048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435004049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435004050 DNA binding residues [nucleotide binding] 479435004051 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435004052 putative DNA binding site [nucleotide binding]; other site 479435004053 dimerization interface [polypeptide binding]; other site 479435004054 putative Zn2+ binding site [ion binding]; other site 479435004055 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435004056 hydrophobic ligand binding site; other site 479435004057 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 479435004058 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479435004059 Walker A/P-loop; other site 479435004060 ATP binding site [chemical binding]; other site 479435004061 Q-loop/lid; other site 479435004062 ABC transporter signature motif; other site 479435004063 Walker B; other site 479435004064 D-loop; other site 479435004065 H-loop/switch region; other site 479435004066 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 479435004067 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435004068 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 479435004069 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 479435004070 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 479435004071 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 479435004072 active site 479435004073 NAD binding site [chemical binding]; other site 479435004074 metal binding site [ion binding]; metal-binding site 479435004075 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 479435004076 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 479435004077 active site 479435004078 metal-binding site 479435004079 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 479435004080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004081 NAD(P) binding site [chemical binding]; other site 479435004082 active site 479435004083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435004084 S-adenosylmethionine binding site [chemical binding]; other site 479435004085 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 479435004086 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 479435004087 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 479435004088 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 479435004089 homodimer interface [polypeptide binding]; other site 479435004090 substrate-cofactor binding pocket; other site 479435004091 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004092 catalytic residue [active] 479435004093 short chain dehydrogenase; Provisional; Region: PRK07074 479435004094 classical (c) SDRs; Region: SDR_c; cd05233 479435004095 NAD(P) binding site [chemical binding]; other site 479435004096 active site 479435004097 TIGR03089 family protein; Region: TIGR03089 479435004098 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479435004099 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435004100 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435004101 Transporter associated domain; Region: CorC_HlyC; pfam03471 479435004102 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435004103 FOG: CBS domain [General function prediction only]; Region: COG0517 479435004104 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435004105 ATP-NAD kinase; Region: NAD_kinase; pfam01513 479435004106 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 479435004107 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 479435004108 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 479435004109 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 479435004110 Substrate binding site; other site 479435004111 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 479435004112 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 479435004113 F420-0:gamma-glutamyl ligase; Region: F420_cofE; TIGR01916 479435004114 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 479435004115 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 479435004116 phosphate binding site [ion binding]; other site 479435004117 dimer interface [polypeptide binding]; other site 479435004118 Transcription factor WhiB; Region: Whib; pfam02467 479435004119 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 479435004120 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 479435004121 Probable Catalytic site; other site 479435004122 metal-binding site 479435004123 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 479435004124 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 479435004125 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435004127 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435004128 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435004129 conserved cys residue [active] 479435004130 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435004131 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435004132 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 479435004133 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 479435004134 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 479435004135 active site 479435004136 substrate binding site [chemical binding]; other site 479435004137 metal binding site [ion binding]; metal-binding site 479435004138 Uncharacterized conserved protein [Function unknown]; Region: COG2835 479435004139 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435004140 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 479435004141 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479435004142 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 479435004143 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 479435004144 Cation efflux family; Region: Cation_efflux; pfam01545 479435004145 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435004146 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435004147 DNA binding residues [nucleotide binding] 479435004148 Adenosylhomocysteinase; Provisional; Region: PTZ00075 479435004149 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 479435004150 homotetramer interface [polypeptide binding]; other site 479435004151 ligand binding site [chemical binding]; other site 479435004152 catalytic site [active] 479435004153 NAD binding site [chemical binding]; other site 479435004154 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435004155 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435004156 active site 479435004157 ATP binding site [chemical binding]; other site 479435004158 substrate binding site [chemical binding]; other site 479435004159 activation loop (A-loop); other site 479435004160 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435004161 metal ion-dependent adhesion site (MIDAS); other site 479435004162 RDD family; Region: RDD; pfam06271 479435004163 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 479435004164 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479435004165 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479435004166 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 479435004167 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 479435004168 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435004169 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435004170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004171 dimer interface [polypeptide binding]; other site 479435004172 conserved gate region; other site 479435004173 putative PBP binding loops; other site 479435004174 ABC-ATPase subunit interface; other site 479435004175 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435004176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004177 dimer interface [polypeptide binding]; other site 479435004178 conserved gate region; other site 479435004179 putative PBP binding loops; other site 479435004180 ABC-ATPase subunit interface; other site 479435004181 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435004182 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435004183 Walker A/P-loop; other site 479435004184 ATP binding site [chemical binding]; other site 479435004185 Q-loop/lid; other site 479435004186 ABC transporter signature motif; other site 479435004187 Walker B; other site 479435004188 D-loop; other site 479435004189 H-loop/switch region; other site 479435004190 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435004191 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435004192 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435004193 Walker A/P-loop; other site 479435004194 ATP binding site [chemical binding]; other site 479435004195 Q-loop/lid; other site 479435004196 ABC transporter signature motif; other site 479435004197 Walker B; other site 479435004198 D-loop; other site 479435004199 H-loop/switch region; other site 479435004200 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435004201 MOSC domain; Region: MOSC; pfam03473 479435004202 Predicted ATPases [General function prediction only]; Region: COG1106 479435004203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435004204 Walker A/P-loop; other site 479435004205 ATP binding site [chemical binding]; other site 479435004206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435004207 Walker B; other site 479435004208 D-loop; other site 479435004209 H-loop/switch region; other site 479435004210 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435004211 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435004212 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435004213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435004214 Walker A motif; other site 479435004215 ATP binding site [chemical binding]; other site 479435004216 Walker B motif; other site 479435004217 arginine finger; other site 479435004218 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 479435004219 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 479435004220 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435004221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435004222 active site 479435004223 phosphorylation site [posttranslational modification] 479435004224 intermolecular recognition site; other site 479435004225 dimerization interface [polypeptide binding]; other site 479435004226 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435004227 DNA binding site [nucleotide binding] 479435004228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435004229 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435004230 dimerization interface [polypeptide binding]; other site 479435004231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435004232 dimer interface [polypeptide binding]; other site 479435004233 phosphorylation site [posttranslational modification] 479435004234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435004235 ATP binding site [chemical binding]; other site 479435004236 Mg2+ binding site [ion binding]; other site 479435004237 G-X-G motif; other site 479435004238 lipoprotein LpqB; Provisional; Region: PRK13613 479435004239 Sporulation and spore germination; Region: Germane; pfam10646 479435004240 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 479435004241 dimer interface [polypeptide binding]; other site 479435004242 ADP-ribose binding site [chemical binding]; other site 479435004243 active site 479435004244 nudix motif; other site 479435004245 metal binding site [ion binding]; metal-binding site 479435004246 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 479435004247 Uncharacterized conserved protein [Function unknown]; Region: COG2128 479435004248 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435004249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004250 putative substrate translocation pore; other site 479435004251 Predicted permeases [General function prediction only]; Region: COG0679 479435004252 comF family protein; Region: comF; TIGR00201 479435004253 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435004254 active site 479435004255 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 479435004256 30S subunit binding site; other site 479435004257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479435004258 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435004259 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 479435004260 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 479435004261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 479435004262 nucleotide binding region [chemical binding]; other site 479435004263 SEC-C motif; Region: SEC-C; pfam02810 479435004264 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 479435004265 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 479435004266 FMN binding site [chemical binding]; other site 479435004267 substrate binding site [chemical binding]; other site 479435004268 putative catalytic residue [active] 479435004269 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004270 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004271 DNA binding site [nucleotide binding] 479435004272 domain linker motif; other site 479435004273 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004274 ligand binding site [chemical binding]; other site 479435004275 dimerization interface [polypeptide binding]; other site 479435004276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004277 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435004278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004279 dimer interface [polypeptide binding]; other site 479435004280 conserved gate region; other site 479435004281 ABC-ATPase subunit interface; other site 479435004282 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004284 dimer interface [polypeptide binding]; other site 479435004285 conserved gate region; other site 479435004286 putative PBP binding loops; other site 479435004287 ABC-ATPase subunit interface; other site 479435004288 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435004289 active site 479435004290 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435004291 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435004292 VanW like protein; Region: VanW; pfam04294 479435004293 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479435004294 Helix-turn-helix domain; Region: HTH_17; pfam12728 479435004295 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 479435004296 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 479435004297 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435004298 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435004299 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 479435004300 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435004301 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 479435004302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435004303 active site 479435004304 motif I; other site 479435004305 motif II; other site 479435004306 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 479435004307 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 479435004308 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 479435004309 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 479435004310 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 479435004311 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 479435004312 putative DNA binding site [nucleotide binding]; other site 479435004313 putative homodimer interface [polypeptide binding]; other site 479435004314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004315 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479435004316 catalytic site [active] 479435004317 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 479435004318 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 479435004319 Glutamate binding site [chemical binding]; other site 479435004320 NAD binding site [chemical binding]; other site 479435004321 catalytic residues [active] 479435004322 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004323 Lipase (class 2); Region: Lipase_2; pfam01674 479435004324 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 479435004325 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435004326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004327 NAD(P) binding site [chemical binding]; other site 479435004328 active site 479435004329 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435004330 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435004331 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435004332 short chain dehydrogenase; Provisional; Region: PRK07454 479435004333 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 479435004334 NADP binding site [chemical binding]; other site 479435004335 substrate binding site [chemical binding]; other site 479435004336 active site 479435004337 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 479435004338 MarR family; Region: MarR_2; pfam12802 479435004339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004340 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 479435004341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435004342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435004343 active site 479435004344 phosphorylation site [posttranslational modification] 479435004345 intermolecular recognition site; other site 479435004346 dimerization interface [polypeptide binding]; other site 479435004347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435004348 DNA binding residues [nucleotide binding] 479435004349 dimerization interface [polypeptide binding]; other site 479435004350 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479435004351 Histidine kinase; Region: HisKA_3; pfam07730 479435004352 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435004353 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435004354 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004355 MarR family; Region: MarR_2; pfam12802 479435004356 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 479435004357 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435004358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435004359 DNA-binding site [nucleotide binding]; DNA binding site 479435004360 UTRA domain; Region: UTRA; pfam07702 479435004361 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004362 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435004363 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435004364 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435004365 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435004366 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479435004367 substrate binding site [chemical binding]; other site 479435004368 ATP binding site [chemical binding]; other site 479435004369 KduI/IolB family; Region: KduI; pfam04962 479435004370 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 479435004371 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435004372 dimer interface [polypeptide binding]; other site 479435004373 PYR/PP interface [polypeptide binding]; other site 479435004374 TPP binding site [chemical binding]; other site 479435004375 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435004376 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 479435004377 TPP-binding site; other site 479435004378 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435004379 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479435004380 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 479435004381 putative ligand binding site [chemical binding]; other site 479435004382 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435004383 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435004384 TM-ABC transporter signature motif; other site 479435004385 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479435004386 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435004387 Walker A/P-loop; other site 479435004388 ATP binding site [chemical binding]; other site 479435004389 Q-loop/lid; other site 479435004390 ABC transporter signature motif; other site 479435004391 Walker B; other site 479435004392 D-loop; other site 479435004393 H-loop/switch region; other site 479435004394 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004395 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435004396 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435004397 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 479435004398 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 479435004399 tetrameric interface [polypeptide binding]; other site 479435004400 NAD binding site [chemical binding]; other site 479435004401 catalytic residues [active] 479435004402 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004403 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435004404 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435004405 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 479435004406 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004407 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435004408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435004409 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435004410 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435004411 DNA-binding site [nucleotide binding]; DNA binding site 479435004412 UTRA domain; Region: UTRA; pfam07702 479435004413 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435004414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435004415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435004416 DNA binding residues [nucleotide binding] 479435004417 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 479435004418 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 479435004419 ATP binding site [chemical binding]; other site 479435004420 Walker A motif; other site 479435004421 hexamer interface [polypeptide binding]; other site 479435004422 Walker B motif; other site 479435004423 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 479435004424 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 479435004425 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 479435004426 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435004427 classical (c) SDRs; Region: SDR_c; cd05233 479435004428 NAD(P) binding site [chemical binding]; other site 479435004429 active site 479435004430 peptide chain release factor 2; Validated; Region: prfB; PRK00578 479435004431 This domain is found in peptide chain release factors; Region: PCRF; smart00937 479435004432 RF-1 domain; Region: RF-1; pfam00472 479435004433 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479435004434 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435004435 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435004436 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 479435004437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435004438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435004439 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435004440 putative dimerization interface [polypeptide binding]; other site 479435004441 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 479435004442 EamA-like transporter family; Region: EamA; pfam00892 479435004443 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 479435004444 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 479435004445 reactive center loop; other site 479435004446 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 479435004447 TIGR03943 family protein; Region: TIGR03943 479435004448 Predicted permease; Region: DUF318; cl17795 479435004449 Predicted permease; Region: DUF318; cl17795 479435004450 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 479435004451 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 479435004452 reactive center loop; other site 479435004453 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004454 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004455 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 479435004456 putative hydrophobic ligand binding site [chemical binding]; other site 479435004457 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 479435004458 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 479435004459 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 479435004460 active site 479435004461 catalytic triad [active] 479435004462 dimer interface [polypeptide binding]; other site 479435004463 phenylhydantoinase; Validated; Region: PRK08323 479435004464 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 479435004465 tetramer interface [polypeptide binding]; other site 479435004466 active site 479435004467 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435004468 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 479435004469 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004471 dimer interface [polypeptide binding]; other site 479435004472 conserved gate region; other site 479435004473 putative PBP binding loops; other site 479435004474 ABC-ATPase subunit interface; other site 479435004475 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435004476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004477 putative PBP binding loops; other site 479435004478 ABC-ATPase subunit interface; other site 479435004479 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004480 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435004481 Histidine kinase; Region: His_kinase; pfam06580 479435004482 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 479435004483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435004484 active site 479435004485 phosphorylation site [posttranslational modification] 479435004486 intermolecular recognition site; other site 479435004487 dimerization interface [polypeptide binding]; other site 479435004488 LytTr DNA-binding domain; Region: LytTR; smart00850 479435004489 BNR repeat-like domain; Region: BNR_2; pfam13088 479435004490 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435004491 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435004492 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435004493 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 479435004494 substrate binding site [chemical binding]; other site 479435004495 ATP binding site [chemical binding]; other site 479435004496 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 479435004497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435004498 Walker A/P-loop; other site 479435004499 ATP binding site [chemical binding]; other site 479435004500 Q-loop/lid; other site 479435004501 ABC transporter signature motif; other site 479435004502 Walker B; other site 479435004503 D-loop; other site 479435004504 H-loop/switch region; other site 479435004505 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 479435004506 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 479435004507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435004508 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435004509 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 479435004510 SmpB-tmRNA interface; other site 479435004511 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435004512 Tic20-like protein; Region: Tic20; pfam09685 479435004513 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435004514 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435004515 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435004516 putative hydrophobic ligand binding site [chemical binding]; other site 479435004517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435004518 putative DNA binding site [nucleotide binding]; other site 479435004519 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 479435004520 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 479435004521 Melibiase; Region: Melibiase; pfam02065 479435004522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004523 dimer interface [polypeptide binding]; other site 479435004524 conserved gate region; other site 479435004525 putative PBP binding loops; other site 479435004526 ABC-ATPase subunit interface; other site 479435004527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004529 dimer interface [polypeptide binding]; other site 479435004530 conserved gate region; other site 479435004531 putative PBP binding loops; other site 479435004532 ABC-ATPase subunit interface; other site 479435004533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004534 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435004535 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 479435004536 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 479435004537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435004538 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435004539 Walker A/P-loop; other site 479435004540 ATP binding site [chemical binding]; other site 479435004541 Q-loop/lid; other site 479435004542 ABC transporter signature motif; other site 479435004543 Walker B; other site 479435004544 D-loop; other site 479435004545 H-loop/switch region; other site 479435004546 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435004547 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479435004548 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 479435004549 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 479435004550 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 479435004551 Moco binding site; other site 479435004552 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479435004553 metal coordination site [ion binding]; other site 479435004554 dimerization interface [polypeptide binding]; other site 479435004555 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 479435004556 EamA-like transporter family; Region: EamA; pfam00892 479435004557 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004558 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004559 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435004560 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479435004561 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435004562 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435004563 DNA binding residues [nucleotide binding] 479435004564 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479435004565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004566 NAD(P) binding site [chemical binding]; other site 479435004567 active site 479435004568 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435004569 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435004570 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435004571 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479435004572 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479435004573 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435004574 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435004575 Walker A/P-loop; other site 479435004576 ATP binding site [chemical binding]; other site 479435004577 Q-loop/lid; other site 479435004578 ABC transporter signature motif; other site 479435004579 Walker B; other site 479435004580 D-loop; other site 479435004581 H-loop/switch region; other site 479435004582 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479435004583 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435004584 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435004585 TM-ABC transporter signature motif; other site 479435004586 Periplasmic binding domain of two-component sensor kinase signaling systems; Region: PBP1_sensor_kinase_like; cd06308 479435004587 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479435004588 putative ligand binding site [chemical binding]; other site 479435004589 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004590 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004591 DNA binding site [nucleotide binding] 479435004592 domain linker motif; other site 479435004593 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004594 dimerization interface [polypeptide binding]; other site 479435004595 ligand binding site [chemical binding]; other site 479435004596 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435004597 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 479435004598 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479435004599 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 479435004600 putative NAD(P) binding site [chemical binding]; other site 479435004601 hypothetical protein; Validated; Region: PRK00228 479435004602 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 479435004603 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 479435004604 putative active site [active] 479435004605 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 479435004606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435004607 ATP binding site [chemical binding]; other site 479435004608 putative Mg++ binding site [ion binding]; other site 479435004609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435004610 salt bridge; other site 479435004611 non-specific DNA binding site [nucleotide binding]; other site 479435004612 sequence-specific DNA binding site [nucleotide binding]; other site 479435004613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004614 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 479435004615 NAD(P) binding site [chemical binding]; other site 479435004616 active site 479435004617 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435004618 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435004619 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 479435004620 AsnC family; Region: AsnC_trans_reg; pfam01037 479435004621 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 479435004622 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 479435004623 dimer interface [polypeptide binding]; other site 479435004624 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 479435004625 active site 479435004626 Fe binding site [ion binding]; other site 479435004627 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004628 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479435004629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435004630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435004631 active site 479435004632 phosphorylation site [posttranslational modification] 479435004633 intermolecular recognition site; other site 479435004634 dimerization interface [polypeptide binding]; other site 479435004635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435004636 DNA binding site [nucleotide binding] 479435004637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435004638 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 479435004639 dimerization interface [polypeptide binding]; other site 479435004640 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435004641 dimer interface [polypeptide binding]; other site 479435004642 phosphorylation site [posttranslational modification] 479435004643 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435004644 ATP binding site [chemical binding]; other site 479435004645 Mg2+ binding site [ion binding]; other site 479435004646 G-X-G motif; other site 479435004647 fumarylacetoacetase; Region: PLN02856 479435004648 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 479435004649 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479435004650 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 479435004651 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 479435004652 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 479435004653 active site 479435004654 metal binding site [ion binding]; metal-binding site 479435004655 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 479435004656 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 479435004657 Isochorismatase family; Region: Isochorismatase; pfam00857 479435004658 catalytic triad [active] 479435004659 metal binding site [ion binding]; metal-binding site 479435004660 conserved cis-peptide bond; other site 479435004661 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435004662 classical (c) SDRs; Region: SDR_c; cd05233 479435004663 NAD(P) binding site [chemical binding]; other site 479435004664 active site 479435004665 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435004666 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004667 NAD(P) binding site [chemical binding]; other site 479435004668 active site 479435004669 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 479435004670 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435004671 Zn binding site [ion binding]; other site 479435004672 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 479435004673 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435004674 Zn binding site [ion binding]; other site 479435004675 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435004676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435004677 DNA binding residues [nucleotide binding] 479435004678 dimerization interface [polypeptide binding]; other site 479435004679 short chain dehydrogenase; Provisional; Region: PRK06482 479435004680 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435004681 NADP binding site [chemical binding]; other site 479435004682 active site 479435004683 steroid binding site; other site 479435004684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435004685 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435004686 PAP2 superfamily; Region: PAP2; pfam01569 479435004687 active site 479435004688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004690 DNA binding site [nucleotide binding] 479435004691 domain linker motif; other site 479435004692 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435004693 putative dimerization interface [polypeptide binding]; other site 479435004694 putative ligand binding site [chemical binding]; other site 479435004695 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004697 dimer interface [polypeptide binding]; other site 479435004698 conserved gate region; other site 479435004699 putative PBP binding loops; other site 479435004700 ABC-ATPase subunit interface; other site 479435004701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004702 dimer interface [polypeptide binding]; other site 479435004703 conserved gate region; other site 479435004704 putative PBP binding loops; other site 479435004705 ABC-ATPase subunit interface; other site 479435004706 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435004707 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435004708 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 479435004709 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 479435004710 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435004711 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 479435004712 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 479435004713 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 479435004714 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004715 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 479435004716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004718 DNA binding site [nucleotide binding] 479435004719 domain linker motif; other site 479435004720 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004721 dimerization interface [polypeptide binding]; other site 479435004722 ligand binding site [chemical binding]; other site 479435004723 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435004725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004726 dimer interface [polypeptide binding]; other site 479435004727 conserved gate region; other site 479435004728 putative PBP binding loops; other site 479435004729 ABC-ATPase subunit interface; other site 479435004730 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004732 dimer interface [polypeptide binding]; other site 479435004733 conserved gate region; other site 479435004734 putative PBP binding loops; other site 479435004735 ABC-ATPase subunit interface; other site 479435004736 putative alpha-glucosidase; Provisional; Region: PRK10658 479435004737 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 479435004738 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 479435004739 active site 479435004740 homotrimer interface [polypeptide binding]; other site 479435004741 catalytic site [active] 479435004742 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 479435004743 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435004744 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 479435004745 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 479435004746 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 479435004747 ligand binding site [chemical binding]; other site 479435004748 MarR family; Region: MarR_2; pfam12802 479435004749 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435004750 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435004751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004752 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435004753 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 479435004754 ABC-ATPase subunit interface; other site 479435004755 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004757 dimer interface [polypeptide binding]; other site 479435004758 conserved gate region; other site 479435004759 putative PBP binding loops; other site 479435004760 ABC-ATPase subunit interface; other site 479435004761 BNR repeat-like domain; Region: BNR_2; pfam13088 479435004762 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 479435004763 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 479435004764 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435004765 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 479435004766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435004767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435004768 DNA binding site [nucleotide binding] 479435004769 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435004770 dimerization interface [polypeptide binding]; other site 479435004771 ligand binding site [chemical binding]; other site 479435004772 hypothetical protein; Provisional; Region: PRK06215 479435004773 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004774 MarR family; Region: MarR; pfam01047 479435004775 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 479435004776 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 479435004777 active site 479435004778 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 479435004779 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 479435004780 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435004781 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 479435004782 active site 479435004783 catalytic tetrad [active] 479435004784 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 479435004785 MPN+ (JAMM) motif; other site 479435004786 Zinc-binding site [ion binding]; other site 479435004787 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479435004788 MoaE interaction surface [polypeptide binding]; other site 479435004789 MoeB interaction surface [polypeptide binding]; other site 479435004790 thiocarboxylated glycine; other site 479435004791 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479435004792 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 479435004793 dimer interface [polypeptide binding]; other site 479435004794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004795 catalytic residue [active] 479435004796 glutamate racemase; Provisional; Region: PRK00865 479435004797 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 479435004798 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435004799 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435004800 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435004801 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 479435004802 active site 479435004803 catalytic triad [active] 479435004804 oxyanion hole [active] 479435004805 ribonuclease PH; Reviewed; Region: rph; PRK00173 479435004806 Ribonuclease PH; Region: RNase_PH_bact; cd11362 479435004807 hexamer interface [polypeptide binding]; other site 479435004808 active site 479435004809 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 479435004810 active site 479435004811 dimerization interface [polypeptide binding]; other site 479435004812 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435004813 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435004814 Coenzyme A binding pocket [chemical binding]; other site 479435004815 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435004816 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435004817 putative substrate translocation pore; other site 479435004818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435004819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435004820 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 479435004821 putative dimerization interface [polypeptide binding]; other site 479435004822 stage V sporulation protein K; Region: spore_V_K; TIGR02881 479435004823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435004824 Walker A motif; other site 479435004825 ATP binding site [chemical binding]; other site 479435004826 Walker B motif; other site 479435004827 arginine finger; other site 479435004828 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 479435004829 metal ion-dependent adhesion site (MIDAS); other site 479435004830 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 479435004831 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 479435004832 catalytic triad [active] 479435004833 Glucose dehydrogenase; Region: glucose_DH; cd08230 479435004834 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435004835 NADP binding site [chemical binding]; other site 479435004836 catalytic Zn binding site [ion binding]; other site 479435004837 structural Zn binding site [ion binding]; other site 479435004838 dimer interface [polypeptide binding]; other site 479435004839 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 479435004840 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 479435004841 oligomerisation interface [polypeptide binding]; other site 479435004842 mobile loop; other site 479435004843 roof hairpin; other site 479435004844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435004845 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435004846 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 479435004847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435004848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004849 homodimer interface [polypeptide binding]; other site 479435004850 catalytic residue [active] 479435004851 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 479435004852 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 479435004853 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 479435004854 dimer interface [polypeptide binding]; other site 479435004855 active site 479435004856 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435004857 substrate binding site [chemical binding]; other site 479435004858 catalytic residue [active] 479435004859 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 479435004860 FAD binding domain; Region: FAD_binding_4; pfam01565 479435004861 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 479435004862 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 479435004863 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435004864 putative dimer interface [polypeptide binding]; other site 479435004865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435004866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435004867 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 479435004868 dimer interface [polypeptide binding]; other site 479435004869 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435004870 tetramer interface [polypeptide binding]; other site 479435004871 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 479435004872 active site 479435004873 Mg2+/Mn2+ binding site [ion binding]; other site 479435004874 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 479435004875 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 479435004876 AlkA N-terminal domain; Region: AlkA_N; pfam06029 479435004877 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479435004878 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435004879 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435004880 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435004881 active site 479435004882 catalytic tetrad [active] 479435004883 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 479435004884 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435004885 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435004886 dimerization interface [polypeptide binding]; other site 479435004887 substrate binding pocket [chemical binding]; other site 479435004888 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435004889 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 479435004890 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 479435004891 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 479435004892 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435004893 Interdomain contacts; other site 479435004894 Cytokine receptor motif; other site 479435004895 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 479435004896 putative metal binding site [ion binding]; other site 479435004897 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 479435004898 active site 479435004899 Isochorismatase family; Region: Isochorismatase; pfam00857 479435004900 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479435004901 catalytic triad [active] 479435004902 conserved cis-peptide bond; other site 479435004903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435004904 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435004905 NAD(P) binding site [chemical binding]; other site 479435004906 active site 479435004907 Phosphotransferase enzyme family; Region: APH; pfam01636 479435004908 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435004909 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 479435004910 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435004911 active site 479435004912 nucleotide binding site [chemical binding]; other site 479435004913 HIGH motif; other site 479435004914 KMSKS motif; other site 479435004915 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 479435004916 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 479435004917 active site 479435004918 metal binding site [ion binding]; metal-binding site 479435004919 nudix motif; other site 479435004920 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 479435004921 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 479435004922 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 479435004923 amphi-Trp domain; Region: amphi-Trp; TIGR04354 479435004924 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435004925 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435004926 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435004927 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435004928 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435004929 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435004930 Coenzyme A binding pocket [chemical binding]; other site 479435004931 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 479435004932 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 479435004933 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435004934 putative DNA binding site [nucleotide binding]; other site 479435004935 putative Zn2+ binding site [ion binding]; other site 479435004936 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479435004937 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 479435004938 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 479435004939 active site 479435004940 catalytic site [active] 479435004941 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479435004942 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435004943 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435004944 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435004945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004946 dimer interface [polypeptide binding]; other site 479435004947 conserved gate region; other site 479435004948 putative PBP binding loops; other site 479435004949 ABC-ATPase subunit interface; other site 479435004950 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435004951 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479435004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435004953 dimer interface [polypeptide binding]; other site 479435004954 putative PBP binding loops; other site 479435004955 ABC-ATPase subunit interface; other site 479435004956 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435004957 MarR family; Region: MarR_2; pfam12802 479435004958 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435004959 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435004960 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 479435004961 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435004962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435004963 homodimer interface [polypeptide binding]; other site 479435004964 catalytic residue [active] 479435004965 GAF domain; Region: GAF; pfam01590 479435004966 GAF domain; Region: GAF_2; pfam13185 479435004967 ANTAR domain; Region: ANTAR; pfam03861 479435004968 Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365 479435004969 Helix-turn-helix domain; Region: HTH_31; pfam13560 479435004970 non-specific DNA binding site [nucleotide binding]; other site 479435004971 salt bridge; other site 479435004972 sequence-specific DNA binding site [nucleotide binding]; other site 479435004973 Domain of unknown function (DUF397); Region: DUF397; pfam04149 479435004974 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435004975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435004976 S-adenosylmethionine binding site [chemical binding]; other site 479435004977 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435004978 hydrophobic ligand binding site; other site 479435004979 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479435004980 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 479435004981 putative dimer interface [polypeptide binding]; other site 479435004982 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435004983 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479435004984 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479435004985 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 479435004986 active site 479435004987 putative catalytic site [active] 479435004988 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 479435004989 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435004990 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435004991 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435004992 DNA binding residues [nucleotide binding] 479435004993 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 479435004994 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 479435004995 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 479435004996 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 479435004997 oxidoreductase; Provisional; Region: PRK06128 479435004998 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 479435004999 NAD binding site [chemical binding]; other site 479435005000 metal binding site [ion binding]; metal-binding site 479435005001 active site 479435005002 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 479435005003 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 479435005004 Helix-turn-helix domain; Region: HTH_38; pfam13936 479435005005 MarR family; Region: MarR_2; pfam12802 479435005006 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005007 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435005008 Walker A/P-loop; other site 479435005009 ATP binding site [chemical binding]; other site 479435005010 Q-loop/lid; other site 479435005011 ABC transporter signature motif; other site 479435005012 Walker B; other site 479435005013 D-loop; other site 479435005014 H-loop/switch region; other site 479435005015 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 479435005016 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435005017 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435005018 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435005019 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435005020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435005021 S-adenosylmethionine binding site [chemical binding]; other site 479435005022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435005023 dimerization interface [polypeptide binding]; other site 479435005024 putative DNA binding site [nucleotide binding]; other site 479435005025 putative Zn2+ binding site [ion binding]; other site 479435005026 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435005027 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435005028 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 479435005029 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 479435005030 hydrophobic ligand binding site; other site 479435005031 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435005032 Cytochrome P450; Region: p450; cl12078 479435005033 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479435005034 PAS domain; Region: PAS_9; pfam13426 479435005035 putative active site [active] 479435005036 heme pocket [chemical binding]; other site 479435005037 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 479435005038 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005039 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479435005040 catalytic site [active] 479435005041 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435005042 GAF domain; Region: GAF; pfam01590 479435005043 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435005044 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435005045 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435005046 DNA binding residues [nucleotide binding] 479435005047 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479435005048 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435005049 NAD binding site [chemical binding]; other site 479435005050 catalytic Zn binding site [ion binding]; other site 479435005051 structural Zn binding site [ion binding]; other site 479435005052 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435005053 putative catalytic site [active] 479435005054 putative metal binding site [ion binding]; other site 479435005055 putative phosphate binding site [ion binding]; other site 479435005056 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435005057 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 479435005058 metal-binding site [ion binding] 479435005059 PknH-like extracellular domain; Region: PknH_C; pfam14032 479435005060 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 479435005061 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435005062 dimerization interface [polypeptide binding]; other site 479435005063 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435005064 dimer interface [polypeptide binding]; other site 479435005065 phosphorylation site [posttranslational modification] 479435005066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435005067 ATP binding site [chemical binding]; other site 479435005068 Mg2+ binding site [ion binding]; other site 479435005069 G-X-G motif; other site 479435005070 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435005071 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435005072 active site 479435005073 phosphorylation site [posttranslational modification] 479435005074 intermolecular recognition site; other site 479435005075 dimerization interface [polypeptide binding]; other site 479435005076 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435005077 DNA binding site [nucleotide binding] 479435005078 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435005079 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005081 Walker A/P-loop; other site 479435005082 ATP binding site [chemical binding]; other site 479435005083 Q-loop/lid; other site 479435005084 ABC transporter signature motif; other site 479435005085 Walker B; other site 479435005086 D-loop; other site 479435005087 H-loop/switch region; other site 479435005088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435005089 salt bridge; other site 479435005090 non-specific DNA binding site [nucleotide binding]; other site 479435005091 sequence-specific DNA binding site [nucleotide binding]; other site 479435005092 short chain dehydrogenase; Provisional; Region: PRK06180 479435005093 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435005094 NADP binding site [chemical binding]; other site 479435005095 active site 479435005096 steroid binding site; other site 479435005097 Conserved TM helix; Region: TM_helix; pfam05552 479435005098 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435005099 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479435005100 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435005101 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435005102 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479435005103 substrate binding site [chemical binding]; other site 479435005104 ATP binding site [chemical binding]; other site 479435005105 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 479435005106 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479435005107 active site 479435005108 intersubunit interface [polypeptide binding]; other site 479435005109 catalytic residue [active] 479435005110 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 479435005111 active site 479435005112 catalytic triad [active] 479435005113 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479435005114 CAAX protease self-immunity; Region: Abi; pfam02517 479435005115 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435005116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435005117 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435005118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435005119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005121 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435005123 active site 479435005124 phosphorylation site [posttranslational modification] 479435005125 intermolecular recognition site; other site 479435005126 dimerization interface [polypeptide binding]; other site 479435005127 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435005128 DNA binding residues [nucleotide binding] 479435005129 dimerization interface [polypeptide binding]; other site 479435005130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435005131 Histidine kinase; Region: HisKA_3; pfam07730 479435005132 haloalkane dehalogenase; Provisional; Region: PRK03592 479435005133 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 479435005134 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435005135 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 479435005136 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 479435005137 DNA binding residues [nucleotide binding] 479435005138 dimer interface [polypeptide binding]; other site 479435005139 [2Fe-2S] cluster binding site [ion binding]; other site 479435005140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005142 short chain dehydrogenase; Provisional; Region: PRK06523 479435005143 classical (c) SDRs; Region: SDR_c; cd05233 479435005144 NAD(P) binding site [chemical binding]; other site 479435005145 active site 479435005146 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005148 NAD(P) binding site [chemical binding]; other site 479435005149 active site 479435005150 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479435005151 substrate binding site [chemical binding]; other site 479435005152 ATP binding site [chemical binding]; other site 479435005153 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 479435005154 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 479435005155 active site 479435005156 catalytic site [active] 479435005157 metal binding site [ion binding]; metal-binding site 479435005158 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 479435005159 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435005160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435005161 dimer interface [polypeptide binding]; other site 479435005162 conserved gate region; other site 479435005163 putative PBP binding loops; other site 479435005164 ABC-ATPase subunit interface; other site 479435005165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435005166 dimer interface [polypeptide binding]; other site 479435005167 conserved gate region; other site 479435005168 putative PBP binding loops; other site 479435005169 ABC-ATPase subunit interface; other site 479435005170 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435005171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435005172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 479435005173 dimerization interface [polypeptide binding]; other site 479435005174 putative DNA binding site [nucleotide binding]; other site 479435005175 putative Zn2+ binding site [ion binding]; other site 479435005176 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435005177 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435005178 nucleotide binding site [chemical binding]; other site 479435005179 Melibiase; Region: Melibiase; pfam02065 479435005180 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435005181 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 479435005182 putative NAD(P) binding site [chemical binding]; other site 479435005183 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435005184 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435005185 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435005186 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435005187 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435005188 Helix-turn-helix domain; Region: HTH_38; pfam13936 479435005189 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435005190 putative DNA binding site [nucleotide binding]; other site 479435005191 putative Zn2+ binding site [ion binding]; other site 479435005192 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435005193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435005194 non-specific DNA binding site [nucleotide binding]; other site 479435005195 salt bridge; other site 479435005196 sequence-specific DNA binding site [nucleotide binding]; other site 479435005197 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435005198 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435005199 AAA ATPase domain; Region: AAA_16; pfam13191 479435005200 NB-ARC domain; Region: NB-ARC; pfam00931 479435005201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435005202 TPR motif; other site 479435005203 binding surface 479435005204 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435005205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435005206 salt bridge; other site 479435005207 non-specific DNA binding site [nucleotide binding]; other site 479435005208 sequence-specific DNA binding site [nucleotide binding]; other site 479435005209 Photosystem II Pbs27; Region: PSII_Pbs27; cl11841 479435005210 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435005211 Carboxylesterase family; Region: COesterase; pfam00135 479435005212 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479435005213 substrate binding pocket [chemical binding]; other site 479435005214 catalytic triad [active] 479435005215 putative ABC transporter-associated repeat protein; Region: anch_rpt_wall; TIGR03773 479435005216 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435005217 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 479435005218 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435005219 ABC-ATPase subunit interface; other site 479435005220 dimer interface [polypeptide binding]; other site 479435005221 putative PBP binding regions; other site 479435005222 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 479435005223 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 479435005224 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435005225 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435005226 anchored repeat ABC transporter, substrate-binding protein; Region: anch_rpt_subst; TIGR03772 479435005227 intersubunit interface [polypeptide binding]; other site 479435005228 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435005229 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435005230 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435005231 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435005232 actinobacterial surface-anchored protein domain; Region: P_ac_wall_RPT; TIGR03769 479435005233 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 479435005234 active site 479435005235 catalytic site [active] 479435005236 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 479435005237 putative deacylase active site [active] 479435005238 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435005239 EamA-like transporter family; Region: EamA; pfam00892 479435005240 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435005241 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435005242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435005243 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 479435005244 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435005245 MarR family; Region: MarR; pfam01047 479435005246 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 479435005247 substrate binding site [chemical binding]; other site 479435005248 catalytic residues [active] 479435005249 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005251 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435005252 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435005253 putative NAD(P) binding site [chemical binding]; other site 479435005254 DJ-1 family protein; Region: not_thiJ; TIGR01383 479435005255 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 479435005256 conserved cys residue [active] 479435005257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435005259 active site 479435005260 phosphorylation site [posttranslational modification] 479435005261 intermolecular recognition site; other site 479435005262 dimerization interface [polypeptide binding]; other site 479435005263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435005264 DNA binding residues [nucleotide binding] 479435005265 dimerization interface [polypeptide binding]; other site 479435005266 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435005267 FAD binding domain; Region: FAD_binding_4; pfam01565 479435005268 Berberine and berberine like; Region: BBE; pfam08031 479435005269 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479435005270 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 479435005271 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 479435005272 AAA ATPase domain; Region: AAA_16; pfam13191 479435005273 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435005275 DNA binding residues [nucleotide binding] 479435005276 dimerization interface [polypeptide binding]; other site 479435005277 MarR family; Region: MarR_2; pfam12802 479435005278 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435005279 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435005280 putative NAD(P) binding site [chemical binding]; other site 479435005281 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435005282 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435005283 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435005284 active site 479435005285 metal binding site [ion binding]; metal-binding site 479435005286 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 479435005287 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435005288 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435005289 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435005290 nucleotide binding site [chemical binding]; other site 479435005291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435005292 Inositol monophosphatase family; Region: Inositol_P; pfam00459 479435005293 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479435005294 active site 479435005295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435005296 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435005297 salt bridge; other site 479435005298 non-specific DNA binding site [nucleotide binding]; other site 479435005299 sequence-specific DNA binding site [nucleotide binding]; other site 479435005300 Uncharacterized conserved protein [Function unknown]; Region: COG5276 479435005301 short chain dehydrogenase; Provisional; Region: PRK06180 479435005302 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 479435005303 NADP binding site [chemical binding]; other site 479435005304 active site 479435005305 steroid binding site; other site 479435005306 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435005307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435005308 putative DNA binding site [nucleotide binding]; other site 479435005309 putative Zn2+ binding site [ion binding]; other site 479435005310 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435005311 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 479435005312 active site 479435005313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005315 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 479435005316 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005317 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005318 NAD(P) binding site [chemical binding]; other site 479435005319 active site 479435005320 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435005321 GAF domain; Region: GAF; pfam01590 479435005322 ANTAR domain; Region: ANTAR; pfam03861 479435005323 Phosphotransferase enzyme family; Region: APH; pfam01636 479435005324 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435005325 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435005326 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435005327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435005328 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435005329 DNA binding residues [nucleotide binding] 479435005330 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435005331 DoxX-like family; Region: DoxX_2; pfam13564 479435005332 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435005333 homotrimer interaction site [polypeptide binding]; other site 479435005334 putative active site [active] 479435005335 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 479435005336 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435005337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005338 LysE type translocator; Region: LysE; cl00565 479435005339 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435005340 Calx-beta domain; Region: Calx-beta; cl02522 479435005341 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 479435005342 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 479435005343 ATP binding site [chemical binding]; other site 479435005344 active site 479435005345 substrate binding site [chemical binding]; other site 479435005346 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435005347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435005348 DNA-binding site [nucleotide binding]; DNA binding site 479435005349 UTRA domain; Region: UTRA; pfam07702 479435005350 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435005351 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479435005352 Helix-turn-helix domain; Region: HTH_17; pfam12728 479435005353 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435005354 active site 479435005355 DNA binding site [nucleotide binding] 479435005356 Int/Topo IB signature motif; other site 479435005357 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479435005358 Putative transcription activator [Transcription]; Region: TenA; COG0819 479435005359 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 479435005360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435005361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435005362 DNA binding site [nucleotide binding] 479435005363 domain linker motif; other site 479435005364 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435005365 dimerization interface [polypeptide binding]; other site 479435005366 ligand binding site [chemical binding]; other site 479435005367 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435005368 dimer interface [polypeptide binding]; other site 479435005369 conserved gate region; other site 479435005370 putative PBP binding loops; other site 479435005371 ABC-ATPase subunit interface; other site 479435005372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435005374 dimer interface [polypeptide binding]; other site 479435005375 conserved gate region; other site 479435005376 putative PBP binding loops; other site 479435005377 ABC-ATPase subunit interface; other site 479435005378 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435005379 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435005380 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435005381 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435005382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435005383 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 479435005384 catalytic site [active] 479435005385 putative active site [active] 479435005386 putative substrate binding site [chemical binding]; other site 479435005387 dimer interface [polypeptide binding]; other site 479435005388 Methyltransferase domain; Region: Methyltransf_12; pfam08242 479435005389 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435005390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435005391 binding surface 479435005392 TPR motif; other site 479435005393 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435005394 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 479435005395 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435005396 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435005397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435005398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005399 Coenzyme A binding pocket [chemical binding]; other site 479435005400 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479435005401 DNA-binding site [nucleotide binding]; DNA binding site 479435005402 RNA-binding motif; other site 479435005403 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 479435005404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005405 Walker A/P-loop; other site 479435005406 ATP binding site [chemical binding]; other site 479435005407 Q-loop/lid; other site 479435005408 ABC transporter signature motif; other site 479435005409 Walker B; other site 479435005410 D-loop; other site 479435005411 H-loop/switch region; other site 479435005412 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435005414 active site 479435005415 phosphorylation site [posttranslational modification] 479435005416 intermolecular recognition site; other site 479435005417 dimerization interface [polypeptide binding]; other site 479435005418 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435005419 DNA binding residues [nucleotide binding] 479435005420 dimerization interface [polypeptide binding]; other site 479435005421 Histidine kinase; Region: HisKA_3; pfam07730 479435005422 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435005423 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 479435005424 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 479435005425 GTP binding site; other site 479435005426 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 479435005427 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 479435005428 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 479435005429 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 479435005430 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435005431 catalytic loop [active] 479435005432 iron binding site [ion binding]; other site 479435005433 4Fe-4S binding domain; Region: Fer4; pfam00037 479435005434 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 479435005435 [4Fe-4S] binding site [ion binding]; other site 479435005436 molybdopterin cofactor binding site; other site 479435005437 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 479435005438 molybdopterin cofactor binding site; other site 479435005439 NADH dehydrogenase subunit E; Validated; Region: PRK07539 479435005440 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435005441 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 479435005442 SLBB domain; Region: SLBB; pfam10531 479435005443 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 479435005444 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 479435005445 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479435005446 dimer interface [polypeptide binding]; other site 479435005447 putative functional site; other site 479435005448 putative MPT binding site; other site 479435005449 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 479435005450 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479435005451 dimer interface [polypeptide binding]; other site 479435005452 putative functional site; other site 479435005453 putative MPT binding site; other site 479435005454 PBP superfamily domain; Region: PBP_like; pfam12727 479435005455 PBP superfamily domain; Region: PBP_like_2; pfam12849 479435005456 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 479435005457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479435005458 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479435005459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005460 Walker A/P-loop; other site 479435005461 ATP binding site [chemical binding]; other site 479435005462 Q-loop/lid; other site 479435005463 ABC transporter signature motif; other site 479435005464 Walker B; other site 479435005465 D-loop; other site 479435005466 H-loop/switch region; other site 479435005467 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 479435005468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 479435005469 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435005470 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 479435005471 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 479435005472 glyoxylate carboligase; Provisional; Region: PRK11269 479435005473 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435005474 PYR/PP interface [polypeptide binding]; other site 479435005475 dimer interface [polypeptide binding]; other site 479435005476 TPP binding site [chemical binding]; other site 479435005477 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435005478 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 479435005479 TPP-binding site [chemical binding]; other site 479435005480 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 479435005481 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 479435005482 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 479435005483 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435005484 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 479435005485 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 479435005486 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435005487 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435005488 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 479435005489 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435005490 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435005491 putative sugar binding sites [chemical binding]; other site 479435005492 Q-X-W motif; other site 479435005493 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435005494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435005495 dimer interface [polypeptide binding]; other site 479435005496 conserved gate region; other site 479435005497 putative PBP binding loops; other site 479435005498 ABC-ATPase subunit interface; other site 479435005499 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435005500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435005501 dimer interface [polypeptide binding]; other site 479435005502 conserved gate region; other site 479435005503 putative PBP binding loops; other site 479435005504 ABC-ATPase subunit interface; other site 479435005505 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435005506 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435005507 DNA binding site [nucleotide binding] 479435005508 domain linker motif; other site 479435005509 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 479435005510 ligand binding site [chemical binding]; other site 479435005511 dimerization interface (open form) [polypeptide binding]; other site 479435005512 dimerization interface (closed form) [polypeptide binding]; other site 479435005513 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 479435005514 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 479435005515 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435005516 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 479435005517 CoA binding domain; Region: CoA_binding; smart00881 479435005518 CoA-ligase; Region: Ligase_CoA; pfam00549 479435005519 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 479435005520 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 479435005521 CoA-ligase; Region: Ligase_CoA; pfam00549 479435005522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435005523 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435005524 hypothetical protein; Provisional; Region: PRK05858 479435005525 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435005526 PYR/PP interface [polypeptide binding]; other site 479435005527 dimer interface [polypeptide binding]; other site 479435005528 TPP binding site [chemical binding]; other site 479435005529 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435005530 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 479435005531 TPP-binding site; other site 479435005532 dimer interface [polypeptide binding]; other site 479435005533 formyl-coenzyme A transferase; Provisional; Region: PRK05398 479435005534 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479435005535 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 479435005536 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 479435005537 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 479435005538 CoA binding domain; Region: CoA_binding_2; pfam13380 479435005539 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 479435005540 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 479435005541 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435005542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435005543 DNA-binding site [nucleotide binding]; DNA binding site 479435005544 FCD domain; Region: FCD; pfam07729 479435005545 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435005546 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435005547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435005548 dimerization interface [polypeptide binding]; other site 479435005549 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005550 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 479435005551 putative active site [active] 479435005552 RibD C-terminal domain; Region: RibD_C; cl17279 479435005553 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435005554 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435005555 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435005556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435005557 S-adenosylmethionine binding site [chemical binding]; other site 479435005558 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435005559 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435005560 DNA binding residues [nucleotide binding] 479435005561 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 479435005562 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 479435005563 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435005564 DNA binding residues [nucleotide binding] 479435005565 putative dimer interface [polypeptide binding]; other site 479435005566 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 479435005567 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 479435005568 Cupin domain; Region: Cupin_2; pfam07883 479435005569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435005570 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 479435005571 homotrimer interaction site [polypeptide binding]; other site 479435005572 putative active site [active] 479435005573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 479435005574 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005575 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 479435005576 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 479435005577 SmpB-tmRNA interface; other site 479435005578 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 479435005579 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435005580 active site 479435005581 DNA binding site [nucleotide binding] 479435005582 Int/Topo IB signature motif; other site 479435005583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435005584 DNA-binding site [nucleotide binding]; DNA binding site 479435005585 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 479435005586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435005587 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435005588 non-specific DNA binding site [nucleotide binding]; other site 479435005589 salt bridge; other site 479435005590 sequence-specific DNA binding site [nucleotide binding]; other site 479435005591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435005592 DNA-binding site [nucleotide binding]; DNA binding site 479435005593 Helix-turn-helix domain; Region: HTH_17; cl17695 479435005594 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 479435005595 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 479435005596 Reovirus minor core protein Mu-2; Region: Reovirus_Mu2; pfam07781 479435005597 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 479435005598 Ti-type conjugative transfer relaxase TraA; Region: TraA_Ti; TIGR02768 479435005599 AAA domain; Region: AAA_30; pfam13604 479435005600 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 479435005601 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 479435005602 cofactor binding site; other site 479435005603 DNA binding site [nucleotide binding] 479435005604 substrate interaction site [chemical binding]; other site 479435005605 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435005606 polymerase nucleotide-binding site; other site 479435005607 DNA-binding residues [nucleotide binding]; DNA binding site 479435005608 nucleotide binding site [chemical binding]; other site 479435005609 primase nucleotide-binding site [nucleotide binding]; other site 479435005610 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 479435005611 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 479435005612 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 479435005613 Protease prsW family; Region: PrsW-protease; pfam13367 479435005614 Dynamin family; Region: Dynamin_N; pfam00350 479435005615 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 479435005616 G1 box; other site 479435005617 GTP/Mg2+ binding site [chemical binding]; other site 479435005618 G2 box; other site 479435005619 Switch I region; other site 479435005620 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 479435005621 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 479435005622 G1 box; other site 479435005623 G1 box; other site 479435005624 GTP/Mg2+ binding site [chemical binding]; other site 479435005625 GTP/Mg2+ binding site [chemical binding]; other site 479435005626 G2 box; other site 479435005627 Switch I region; other site 479435005628 G3 box; other site 479435005629 Switch II region; other site 479435005630 G4 box; other site 479435005631 G5 box; other site 479435005632 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435005633 putative hydrophobic ligand binding site [chemical binding]; other site 479435005634 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479435005635 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479435005636 dimer interface [polypeptide binding]; other site 479435005637 ssDNA binding site [nucleotide binding]; other site 479435005638 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435005639 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 479435005640 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005641 Walker A/P-loop; other site 479435005642 ATP binding site [chemical binding]; other site 479435005643 Q-loop/lid; other site 479435005644 ABC transporter signature motif; other site 479435005645 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435005646 ABC transporter; Region: ABC_tran_2; pfam12848 479435005647 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435005648 Cupin; Region: Cupin_6; pfam12852 479435005649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005650 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435005651 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435005652 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435005653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005654 NAD(P) binding site [chemical binding]; other site 479435005655 active site 479435005656 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435005657 MarR family; Region: MarR_2; pfam12802 479435005658 YceI-like domain; Region: YceI; smart00867 479435005659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435005660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435005661 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435005662 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435005663 active site 479435005664 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 479435005665 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435005666 dimer interface [polypeptide binding]; other site 479435005667 active site 479435005668 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479435005669 classical (c) SDRs; Region: SDR_c; cd05233 479435005670 NAD(P) binding site [chemical binding]; other site 479435005671 active site 479435005672 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435005673 TIGR03086 family protein; Region: TIGR03086 479435005674 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435005675 HTH domain; Region: HTH_11; pfam08279 479435005676 WYL domain; Region: WYL; pfam13280 479435005677 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005678 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435005679 Walker A/P-loop; other site 479435005680 ATP binding site [chemical binding]; other site 479435005681 Q-loop/lid; other site 479435005682 ABC transporter signature motif; other site 479435005683 Walker B; other site 479435005684 D-loop; other site 479435005685 H-loop/switch region; other site 479435005686 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005687 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435005688 Walker A/P-loop; other site 479435005689 ATP binding site [chemical binding]; other site 479435005690 Q-loop/lid; other site 479435005691 ABC transporter signature motif; other site 479435005692 Walker B; other site 479435005693 D-loop; other site 479435005694 H-loop/switch region; other site 479435005695 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435005696 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005697 Coenzyme A binding pocket [chemical binding]; other site 479435005698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435005699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005700 Coenzyme A binding pocket [chemical binding]; other site 479435005701 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 479435005702 putative active site [active] 479435005703 putative catalytic site [active] 479435005704 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435005705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435005706 NAD(P) binding site [chemical binding]; other site 479435005707 active site 479435005708 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 479435005709 active site 479435005710 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 479435005711 active site 479435005712 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 479435005713 apolar tunnel; other site 479435005714 heme binding site [chemical binding]; other site 479435005715 dimerization interface [polypeptide binding]; other site 479435005716 OsmC-like protein; Region: OsmC; cl00767 479435005717 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 479435005718 Mechanosensitive ion channel; Region: MS_channel; pfam00924 479435005719 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435005720 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 479435005721 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 479435005722 Chitin binding domain; Region: Chitin_bind_3; pfam03067 479435005723 Repair protein; Region: Repair_PSII; pfam04536 479435005724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435005725 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435005726 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435005727 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479435005728 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479435005729 Zn binding site [ion binding]; other site 479435005730 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 479435005731 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 479435005732 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479435005733 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 479435005734 putative DNA binding site [nucleotide binding]; other site 479435005735 catalytic residue [active] 479435005736 putative H2TH interface [polypeptide binding]; other site 479435005737 putative catalytic residues [active] 479435005738 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435005739 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435005740 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 479435005741 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 479435005742 active site 479435005743 putative catalytic site [active] 479435005744 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435005745 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435005746 putative DNA binding site [nucleotide binding]; other site 479435005747 putative Zn2+ binding site [ion binding]; other site 479435005748 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435005749 hydrophobic ligand binding site; other site 479435005750 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435005751 dimerization interface [polypeptide binding]; other site 479435005752 putative DNA binding site [nucleotide binding]; other site 479435005753 putative Zn2+ binding site [ion binding]; other site 479435005754 Domain of unknown function (DUF385); Region: DUF385; pfam04075 479435005755 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 479435005756 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 479435005757 Predicted ATPase [General function prediction only]; Region: COG4637 479435005758 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005759 Walker A/P-loop; other site 479435005760 ATP binding site [chemical binding]; other site 479435005761 Q-loop/lid; other site 479435005762 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435005763 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435005764 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435005765 putative dimerization interface [polypeptide binding]; other site 479435005766 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435005767 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435005768 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435005769 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 479435005770 NADP binding site [chemical binding]; other site 479435005771 dimer interface [polypeptide binding]; other site 479435005772 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435005773 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435005774 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005775 Walker A/P-loop; other site 479435005776 ATP binding site [chemical binding]; other site 479435005777 Q-loop/lid; other site 479435005778 ABC transporter signature motif; other site 479435005779 Walker B; other site 479435005780 D-loop; other site 479435005781 H-loop/switch region; other site 479435005782 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435005783 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435005784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005785 Walker A/P-loop; other site 479435005786 ATP binding site [chemical binding]; other site 479435005787 Q-loop/lid; other site 479435005788 ABC transporter signature motif; other site 479435005789 Walker B; other site 479435005790 D-loop; other site 479435005791 H-loop/switch region; other site 479435005792 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435005793 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435005794 S-adenosylmethionine binding site [chemical binding]; other site 479435005795 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 479435005796 nudix motif; other site 479435005797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435005798 S-adenosylmethionine binding site [chemical binding]; other site 479435005799 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479435005800 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435005801 DinB superfamily; Region: DinB_2; pfam12867 479435005802 YCII-related domain; Region: YCII; cl00999 479435005803 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 479435005804 trigger factor; Provisional; Region: tig; PRK01490 479435005805 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 479435005806 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 479435005807 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435005808 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435005809 active site 479435005810 catalytic tetrad [active] 479435005811 Clp protease; Region: CLP_protease; pfam00574 479435005812 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435005813 oligomer interface [polypeptide binding]; other site 479435005814 active site residues [active] 479435005815 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 479435005816 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435005817 oligomer interface [polypeptide binding]; other site 479435005818 active site residues [active] 479435005819 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 479435005820 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 479435005821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435005822 Walker A motif; other site 479435005823 ATP binding site [chemical binding]; other site 479435005824 Walker B motif; other site 479435005825 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 479435005826 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435005827 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005828 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 479435005829 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435005830 active site 479435005831 HIGH motif; other site 479435005832 nucleotide binding site [chemical binding]; other site 479435005833 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435005834 active site 479435005835 KMSKS motif; other site 479435005836 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 479435005837 tRNA binding surface [nucleotide binding]; other site 479435005838 anticodon binding site; other site 479435005839 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 479435005840 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435005841 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435005842 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 479435005843 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 479435005844 active site 479435005845 multimer interface [polypeptide binding]; other site 479435005846 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 479435005847 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435005848 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435005849 AAA ATPase domain; Region: AAA_16; pfam13191 479435005850 AAA domain; Region: AAA_22; pfam13401 479435005851 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435005852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435005853 binding surface 479435005854 TPR motif; other site 479435005855 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 479435005856 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479435005857 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479435005858 RHS Repeat; Region: RHS_repeat; pfam05593 479435005859 RHS Repeat; Region: RHS_repeat; pfam05593 479435005860 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435005861 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 479435005862 rod shape-determining protein MreB; Provisional; Region: PRK13927 479435005863 MreB and similar proteins; Region: MreB_like; cd10225 479435005864 nucleotide binding site [chemical binding]; other site 479435005865 Mg binding site [ion binding]; other site 479435005866 putative protofilament interaction site [polypeptide binding]; other site 479435005867 RodZ interaction site [polypeptide binding]; other site 479435005868 rod shape-determining protein MreC; Provisional; Region: PRK13922 479435005869 Septum formation initiator; Region: DivIC; cl17659 479435005870 rod shape-determining protein MreC; Region: MreC; pfam04085 479435005871 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 479435005872 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479435005873 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 479435005874 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 479435005875 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435005876 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435005877 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435005878 homotrimer interaction site [polypeptide binding]; other site 479435005879 putative active site [active] 479435005880 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435005881 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 479435005882 putative DNA binding site [nucleotide binding]; other site 479435005883 putative Zn2+ binding site [ion binding]; other site 479435005884 AsnC family; Region: AsnC_trans_reg; pfam01037 479435005885 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 479435005886 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435005887 L-asparaginase II; Region: Asparaginase_II; pfam06089 479435005888 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 479435005889 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435005890 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 479435005891 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 479435005892 B12 binding site [chemical binding]; other site 479435005893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435005894 FeS/SAM binding site; other site 479435005895 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 479435005896 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 479435005897 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 479435005898 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 479435005899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435005900 active site 479435005901 motif I; other site 479435005902 motif II; other site 479435005903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005904 Coenzyme A binding pocket [chemical binding]; other site 479435005905 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435005906 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435005907 active site 479435005908 catalytic residues [active] 479435005909 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435005910 Coenzyme A binding pocket [chemical binding]; other site 479435005911 prephenate dehydratase; Provisional; Region: PRK11899 479435005912 Prephenate dehydratase; Region: PDT; pfam00800 479435005913 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 479435005914 putative L-Phe binding site [chemical binding]; other site 479435005915 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435005916 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435005917 putative acyl-acceptor binding pocket; other site 479435005918 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 479435005919 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 479435005920 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105 479435005921 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 479435005922 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 479435005923 homodimer interface [polypeptide binding]; other site 479435005924 oligonucleotide binding site [chemical binding]; other site 479435005925 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 479435005926 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 479435005927 GTPase CgtA; Reviewed; Region: obgE; PRK12296 479435005928 GTP1/OBG; Region: GTP1_OBG; pfam01018 479435005929 Obg GTPase; Region: Obg; cd01898 479435005930 G1 box; other site 479435005931 GTP/Mg2+ binding site [chemical binding]; other site 479435005932 Switch I region; other site 479435005933 G2 box; other site 479435005934 G3 box; other site 479435005935 Switch II region; other site 479435005936 G4 box; other site 479435005937 G5 box; other site 479435005938 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 479435005939 gamma-glutamyl kinase; Provisional; Region: PRK05429 479435005940 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 479435005941 nucleotide binding site [chemical binding]; other site 479435005942 homotetrameric interface [polypeptide binding]; other site 479435005943 putative phosphate binding site [ion binding]; other site 479435005944 putative allosteric binding site; other site 479435005945 PUA domain; Region: PUA; pfam01472 479435005946 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 479435005947 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 479435005948 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 479435005949 putative catalytic cysteine [active] 479435005950 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435005951 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435005952 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435005953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435005954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435005955 putative substrate translocation pore; other site 479435005956 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479435005957 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 479435005958 putative DNA binding site [nucleotide binding]; other site 479435005959 putative Zn2+ binding site [ion binding]; other site 479435005960 AsnC family; Region: AsnC_trans_reg; pfam01037 479435005961 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 479435005962 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 479435005963 active site 479435005964 (T/H)XGH motif; other site 479435005965 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 479435005966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435005967 catalytic core [active] 479435005968 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435005969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435005970 Walker A/P-loop; other site 479435005971 ATP binding site [chemical binding]; other site 479435005972 Q-loop/lid; other site 479435005973 ABC transporter signature motif; other site 479435005974 Walker B; other site 479435005975 D-loop; other site 479435005976 H-loop/switch region; other site 479435005977 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435005978 Histidine kinase; Region: HisKA_3; pfam07730 479435005979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435005980 ATP binding site [chemical binding]; other site 479435005981 Mg2+ binding site [ion binding]; other site 479435005982 G-X-G motif; other site 479435005983 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435005984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435005985 active site 479435005986 phosphorylation site [posttranslational modification] 479435005987 intermolecular recognition site; other site 479435005988 dimerization interface [polypeptide binding]; other site 479435005989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435005990 DNA binding residues [nucleotide binding] 479435005991 dimerization interface [polypeptide binding]; other site 479435005992 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435005993 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 479435005994 SnoaL-like domain; Region: SnoaL_3; pfam13474 479435005995 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435005996 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435005997 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435005998 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 479435005999 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435006000 substrate binding pocket [chemical binding]; other site 479435006001 membrane-bound complex binding site; other site 479435006002 hinge residues; other site 479435006003 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435006004 putative catalytic site [active] 479435006005 putative metal binding site [ion binding]; other site 479435006006 putative phosphate binding site [ion binding]; other site 479435006007 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435006008 S-adenosylmethionine binding site [chemical binding]; other site 479435006009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435006010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435006011 non-specific DNA binding site [nucleotide binding]; other site 479435006012 salt bridge; other site 479435006013 sequence-specific DNA binding site [nucleotide binding]; other site 479435006014 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435006015 classical (c) SDRs; Region: SDR_c; cd05233 479435006016 NAD(P) binding site [chemical binding]; other site 479435006017 active site 479435006018 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435006019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006020 Coenzyme A binding pocket [chemical binding]; other site 479435006021 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435006022 active site 479435006023 ATP binding site [chemical binding]; other site 479435006024 Phosphotransferase enzyme family; Region: APH; pfam01636 479435006025 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435006026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435006027 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435006028 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435006029 DNA binding site [nucleotide binding] 479435006030 domain linker motif; other site 479435006031 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435006032 dimerization interface [polypeptide binding]; other site 479435006033 ligand binding site [chemical binding]; other site 479435006034 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435006035 conserved cys residue [active] 479435006036 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435006037 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435006038 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435006039 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 479435006040 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479435006041 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435006042 LLM-partnered FMN reductase, CE1759 family; Region: LLM_duo_CE1759; TIGR04037 479435006043 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 479435006044 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 479435006045 siderophore binding site; other site 479435006046 BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in...; Region: BAH; cl02608 479435006047 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435006048 putative catalytic site [active] 479435006049 putative metal binding site [ion binding]; other site 479435006050 putative phosphate binding site [ion binding]; other site 479435006051 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435006052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435006053 active site 479435006054 phosphorylation site [posttranslational modification] 479435006055 intermolecular recognition site; other site 479435006056 dimerization interface [polypeptide binding]; other site 479435006057 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435006058 DNA binding residues [nucleotide binding] 479435006059 dimerization interface [polypeptide binding]; other site 479435006060 Histidine kinase; Region: HisKA_3; pfam07730 479435006061 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435006062 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u2; cd11478 479435006063 Na binding site [ion binding]; other site 479435006064 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435006065 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 479435006066 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479435006067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006069 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 479435006070 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 479435006071 HIGH motif; other site 479435006072 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 479435006073 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435006074 active site 479435006075 KMSKS motif; other site 479435006076 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 479435006077 tRNA binding surface [nucleotide binding]; other site 479435006078 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 479435006079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435006080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435006081 non-specific DNA binding site [nucleotide binding]; other site 479435006082 salt bridge; other site 479435006083 sequence-specific DNA binding site [nucleotide binding]; other site 479435006084 Predicted ATPase [General function prediction only]; Region: COG3903 479435006085 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479435006086 EDD domain protein, DegV family; Region: DegV; TIGR00762 479435006087 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 479435006088 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 479435006089 Helix-hairpin-helix motif; Region: HHH; pfam00633 479435006090 Competence protein; Region: Competence; pfam03772 479435006091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435006092 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 479435006093 hypothetical protein; Reviewed; Region: PRK07914 479435006094 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 479435006095 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 479435006096 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435006097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435006098 DNA binding site [nucleotide binding] 479435006099 domain linker motif; other site 479435006100 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435006101 dimerization interface [polypeptide binding]; other site 479435006102 ligand binding site [chemical binding]; other site 479435006103 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435006104 putative sugar binding sites [chemical binding]; other site 479435006105 Q-X-W motif; other site 479435006106 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 479435006107 Peptidase S8 family domain, uncharacterized subfamily 3; Region: Peptidases_S8_3; cd04852 479435006108 active site 479435006109 catalytic triad [active] 479435006110 PA_subtilisin_like: Protease-associated domain containing subtilisin-like proteases. This group contains various PA domain-containing subtilisin-like proteases including melon cucumisin, Arabidopsis thaliana Ara12, a nodule specific serine protease from...; Region: PA_subtilisin_like; cd02120 479435006111 PA/protease or protease-like domain interface [polypeptide binding]; other site 479435006112 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435006113 catalytic residues [active] 479435006114 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435006115 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006116 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435006117 DNA binding residues [nucleotide binding] 479435006118 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435006119 active site 479435006120 substrate binding site [chemical binding]; other site 479435006121 ATP binding site [chemical binding]; other site 479435006122 Phosphotransferase enzyme family; Region: APH; pfam01636 479435006123 GTP-binding protein LepA; Provisional; Region: PRK05433 479435006124 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 479435006125 G1 box; other site 479435006126 putative GEF interaction site [polypeptide binding]; other site 479435006127 GTP/Mg2+ binding site [chemical binding]; other site 479435006128 Switch I region; other site 479435006129 G2 box; other site 479435006130 G3 box; other site 479435006131 Switch II region; other site 479435006132 G4 box; other site 479435006133 G5 box; other site 479435006134 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 479435006135 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 479435006136 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 479435006137 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; pfam04655 479435006138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 479435006139 MOSC domain; Region: MOSC; pfam03473 479435006140 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435006141 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 479435006142 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435006143 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435006144 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 479435006145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006146 NAD(P) binding site [chemical binding]; other site 479435006147 active site 479435006148 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 479435006149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435006150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435006151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435006152 dimer interface [polypeptide binding]; other site 479435006153 conserved gate region; other site 479435006154 putative PBP binding loops; other site 479435006155 ABC-ATPase subunit interface; other site 479435006156 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435006157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435006158 dimer interface [polypeptide binding]; other site 479435006159 conserved gate region; other site 479435006160 putative PBP binding loops; other site 479435006161 ABC-ATPase subunit interface; other site 479435006162 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 479435006163 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435006164 metal binding site [ion binding]; metal-binding site 479435006165 substrate binding pocket [chemical binding]; other site 479435006166 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 479435006167 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 479435006168 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 479435006169 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435006170 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 479435006171 acyl-activating enzyme (AAE) consensus motif; other site 479435006172 putative AMP binding site [chemical binding]; other site 479435006173 putative active site [active] 479435006174 putative CoA binding site [chemical binding]; other site 479435006175 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 479435006176 Transglycosylase; Region: Transgly; pfam00912 479435006177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 479435006178 coproporphyrinogen III oxidase; Validated; Region: PRK05628 479435006179 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435006180 FeS/SAM binding site; other site 479435006181 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435006182 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435006183 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435006184 DNA binding site [nucleotide binding] 479435006185 domain linker motif; other site 479435006186 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435006187 putative dimerization interface [polypeptide binding]; other site 479435006188 putative ligand binding site [chemical binding]; other site 479435006189 patatin-related protein; Region: TIGR03607 479435006190 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 479435006191 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 479435006192 putative active site [active] 479435006193 uncharacterized nucleobase-cation-symport-1 (NCS1) transporter subfamily, YbbW-like; solute-binding domain; Region: SLC-NCS1sbd_YbbW-like; cd11485 479435006194 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 479435006195 Na binding site [ion binding]; other site 479435006196 putative substrate binding site [chemical binding]; other site 479435006197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435006198 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435006199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435006200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435006201 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 479435006202 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 479435006203 chaperone protein DnaJ; Provisional; Region: PRK14278 479435006204 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 479435006205 HSP70 interaction site [polypeptide binding]; other site 479435006206 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 479435006207 Zn binding sites [ion binding]; other site 479435006208 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 479435006209 dimer interface [polypeptide binding]; other site 479435006210 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 479435006211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435006212 S-adenosylmethionine binding site [chemical binding]; other site 479435006213 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 479435006214 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435006215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006216 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435006217 DNA binding residues [nucleotide binding] 479435006218 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 479435006219 PhoH-like protein; Region: PhoH; pfam02562 479435006220 metal-binding heat shock protein; Provisional; Region: PRK00016 479435006221 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 479435006222 Domain of unknown function DUF21; Region: DUF21; pfam01595 479435006223 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 479435006224 Transporter associated domain; Region: CorC_HlyC; smart01091 479435006225 GTPase Era; Reviewed; Region: era; PRK00089 479435006226 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 479435006227 G1 box; other site 479435006228 GTP/Mg2+ binding site [chemical binding]; other site 479435006229 Switch I region; other site 479435006230 G2 box; other site 479435006231 Switch II region; other site 479435006232 G3 box; other site 479435006233 G4 box; other site 479435006234 G5 box; other site 479435006235 KH domain; Region: KH_2; pfam07650 479435006236 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006237 Coenzyme A binding pocket [chemical binding]; other site 479435006238 short chain dehydrogenase; Provisional; Region: PRK06500 479435006239 classical (c) SDRs; Region: SDR_c; cd05233 479435006240 NAD(P) binding site [chemical binding]; other site 479435006241 active site 479435006242 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435006243 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435006244 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435006245 metal binding site 2 [ion binding]; metal-binding site 479435006246 putative DNA binding helix; other site 479435006247 metal binding site 1 [ion binding]; metal-binding site 479435006248 dimer interface [polypeptide binding]; other site 479435006249 structural Zn2+ binding site [ion binding]; other site 479435006250 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 479435006251 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 479435006252 dimer interface [polypeptide binding]; other site 479435006253 active site 479435006254 heme binding site [chemical binding]; other site 479435006255 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 479435006256 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479435006257 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 479435006258 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479435006259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006261 2-isopropylmalate synthase; Validated; Region: PRK03739 479435006262 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 479435006263 active site 479435006264 catalytic residues [active] 479435006265 metal binding site [ion binding]; metal-binding site 479435006266 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 479435006267 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006268 Coenzyme A binding pocket [chemical binding]; other site 479435006269 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435006270 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435006271 nudix motif; other site 479435006272 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435006273 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435006274 Walker A/P-loop; other site 479435006275 ATP binding site [chemical binding]; other site 479435006276 Q-loop/lid; other site 479435006277 ABC transporter signature motif; other site 479435006278 Walker B; other site 479435006279 D-loop; other site 479435006280 H-loop/switch region; other site 479435006281 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435006282 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435006283 Walker A/P-loop; other site 479435006284 ATP binding site [chemical binding]; other site 479435006285 Q-loop/lid; other site 479435006286 ABC transporter signature motif; other site 479435006287 Walker B; other site 479435006288 D-loop; other site 479435006289 H-loop/switch region; other site 479435006290 FtsX-like permease family; Region: FtsX; pfam02687 479435006291 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435006292 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 479435006293 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435006294 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435006295 active site 479435006296 catalytic tetrad [active] 479435006297 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 479435006298 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435006299 NADP binding site [chemical binding]; other site 479435006300 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435006301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006302 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435006303 DNA binding residues [nucleotide binding] 479435006304 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 479435006305 Recombination protein O N terminal; Region: RecO_N; pfam11967 479435006306 Recombination protein O C terminal; Region: RecO_C; pfam02565 479435006307 PIN domain; Region: PIN_3; pfam13470 479435006308 The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Region: NR_LBD; cl11397 479435006309 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 479435006310 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 479435006311 catalytic residue [active] 479435006312 putative FPP diphosphate binding site; other site 479435006313 putative FPP binding hydrophobic cleft; other site 479435006314 dimer interface [polypeptide binding]; other site 479435006315 putative IPP diphosphate binding site; other site 479435006316 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435006318 active site 479435006319 phosphorylation site [posttranslational modification] 479435006320 intermolecular recognition site; other site 479435006321 dimerization interface [polypeptide binding]; other site 479435006322 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435006323 DNA binding residues [nucleotide binding] 479435006324 dimerization interface [polypeptide binding]; other site 479435006325 Histidine kinase; Region: HisKA_3; pfam07730 479435006326 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435006327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435006328 ATP binding site [chemical binding]; other site 479435006329 Mg2+ binding site [ion binding]; other site 479435006330 G-X-G motif; other site 479435006331 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435006332 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435006333 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435006334 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435006335 Walker A/P-loop; other site 479435006336 ATP binding site [chemical binding]; other site 479435006337 Q-loop/lid; other site 479435006338 ABC transporter signature motif; other site 479435006339 Walker B; other site 479435006340 D-loop; other site 479435006341 H-loop/switch region; other site 479435006342 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 479435006343 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 479435006344 NAD binding site [chemical binding]; other site 479435006345 catalytic Zn binding site [ion binding]; other site 479435006346 substrate binding site [chemical binding]; other site 479435006347 structural Zn binding site [ion binding]; other site 479435006348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435006349 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 479435006350 metal binding site 2 [ion binding]; metal-binding site 479435006351 putative DNA binding helix; other site 479435006352 metal binding site 1 [ion binding]; metal-binding site 479435006353 dimer interface [polypeptide binding]; other site 479435006354 structural Zn2+ binding site [ion binding]; other site 479435006355 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 479435006356 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435006357 ABC-ATPase subunit interface; other site 479435006358 dimer interface [polypeptide binding]; other site 479435006359 putative PBP binding regions; other site 479435006360 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479435006361 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 479435006362 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435006363 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 479435006364 intersubunit interface [polypeptide binding]; other site 479435006365 YibE/F-like protein; Region: YibE_F; pfam07907 479435006366 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435006367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435006368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435006369 DNA binding site [nucleotide binding] 479435006370 domain linker motif; other site 479435006371 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435006372 putative dimerization interface [polypeptide binding]; other site 479435006373 putative ligand binding site [chemical binding]; other site 479435006374 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435006375 sugar binding site [chemical binding]; other site 479435006376 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435006377 sugar binding site [chemical binding]; other site 479435006378 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 479435006379 active site 479435006380 catalytic residues [active] 479435006381 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435006382 sugar binding site [chemical binding]; other site 479435006383 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 479435006384 Domain of unknown function (DUF305); Region: DUF305; cl17794 479435006385 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 479435006386 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435006387 active site 479435006388 ATP binding site [chemical binding]; other site 479435006389 substrate binding site [chemical binding]; other site 479435006390 activation loop (A-loop); other site 479435006391 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 479435006392 active site 479435006393 zinc binding site [ion binding]; other site 479435006394 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479435006395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435006396 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435006397 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435006398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435006399 Q-loop/lid; other site 479435006400 ABC transporter signature motif; other site 479435006401 Walker B; other site 479435006402 D-loop; other site 479435006403 H-loop/switch region; other site 479435006404 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435006405 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479435006406 Walker A/P-loop; other site 479435006407 ATP binding site [chemical binding]; other site 479435006408 Q-loop/lid; other site 479435006409 ABC transporter signature motif; other site 479435006410 Walker B; other site 479435006411 D-loop; other site 479435006412 H-loop/switch region; other site 479435006413 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435006414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435006415 DNA binding residues [nucleotide binding] 479435006416 dimerization interface [polypeptide binding]; other site 479435006417 hypothetical protein; Provisional; Region: PRK07588 479435006418 hypothetical protein; Provisional; Region: PRK07236 479435006419 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435006420 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435006421 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 479435006422 glycyl-tRNA synthetase; Provisional; Region: PRK04173 479435006423 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 479435006424 dimer interface [polypeptide binding]; other site 479435006425 motif 1; other site 479435006426 active site 479435006427 motif 2; other site 479435006428 motif 3; other site 479435006429 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 479435006430 anticodon binding site; other site 479435006431 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 479435006432 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 479435006433 FMN binding site [chemical binding]; other site 479435006434 active site 479435006435 catalytic residues [active] 479435006436 substrate binding site [chemical binding]; other site 479435006437 Uncharacterized conserved protein [Function unknown]; Region: COG3342 479435006438 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 479435006439 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479435006440 nucleotide binding site [chemical binding]; other site 479435006441 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 479435006442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435006443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435006444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479435006445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435006446 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435006447 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435006448 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 479435006449 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 479435006450 active site 479435006451 SUMO-1 interface [polypeptide binding]; other site 479435006452 Clp amino terminal domain; Region: Clp_N; pfam02861 479435006453 Clp amino terminal domain; Region: Clp_N; pfam02861 479435006454 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435006455 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435006456 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 479435006457 DNA binding residues [nucleotide binding] 479435006458 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435006459 putative dimer interface [polypeptide binding]; other site 479435006460 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 479435006461 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435006462 DNA binding residues [nucleotide binding] 479435006463 putative dimer interface [polypeptide binding]; other site 479435006464 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 479435006465 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 479435006466 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 479435006467 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 479435006468 metal ion-dependent adhesion site (MIDAS); other site 479435006469 pyruvate phosphate dikinase; Provisional; Region: PRK09279 479435006470 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479435006471 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479435006472 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 479435006473 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435006474 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006475 NAD(P) binding site [chemical binding]; other site 479435006476 active site 479435006477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 479435006478 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435006479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435006480 non-specific DNA binding site [nucleotide binding]; other site 479435006481 salt bridge; other site 479435006482 sequence-specific DNA binding site [nucleotide binding]; other site 479435006483 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 479435006484 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 479435006485 putative active site [active] 479435006486 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435006487 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435006488 TIGR03086 family protein; Region: TIGR03086 479435006489 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435006490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435006491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435006492 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 479435006493 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435006494 FAD binding domain; Region: FAD_binding_4; pfam01565 479435006495 Berberine and berberine like; Region: BBE; pfam08031 479435006496 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 479435006497 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435006498 Zn2+ binding site [ion binding]; other site 479435006499 Mg2+ binding site [ion binding]; other site 479435006500 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 479435006501 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435006502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435006503 DNA-binding site [nucleotide binding]; DNA binding site 479435006504 FCD domain; Region: FCD; pfam07729 479435006505 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 479435006506 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435006507 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435006508 DNA primase; Validated; Region: dnaG; PRK05667 479435006509 CHC2 zinc finger; Region: zf-CHC2; pfam01807 479435006510 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 479435006511 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 479435006512 active site 479435006513 metal binding site [ion binding]; metal-binding site 479435006514 interdomain interaction site; other site 479435006515 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 479435006516 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 479435006517 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 479435006518 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 479435006519 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006520 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435006521 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 479435006522 DNA binding residues [nucleotide binding] 479435006523 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 479435006524 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 479435006525 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435006526 catalytic residue [active] 479435006527 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435006528 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435006529 DNA-binding site [nucleotide binding]; DNA binding site 479435006530 FCD domain; Region: FCD; pfam07729 479435006531 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435006532 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 479435006533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435006534 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 479435006535 active site 479435006536 Isochorismatase family; Region: Isochorismatase; pfam00857 479435006537 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479435006538 catalytic triad [active] 479435006539 conserved cis-peptide bond; other site 479435006540 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435006541 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435006542 conserved cys residue [active] 479435006543 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006544 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435006545 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435006546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006547 NAD(P) binding site [chemical binding]; other site 479435006548 active site 479435006549 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435006550 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435006551 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435006552 RibD C-terminal domain; Region: RibD_C; cl17279 479435006553 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 479435006554 metal binding site [ion binding]; metal-binding site 479435006555 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435006556 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435006557 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435006558 active site 479435006559 NTP binding site [chemical binding]; other site 479435006560 metal binding triad [ion binding]; metal-binding site 479435006561 antibiotic binding site [chemical binding]; other site 479435006562 argininosuccinate synthase; Validated; Region: PRK05370 479435006563 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435006564 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 479435006565 putative catalytic site [active] 479435006566 putative phosphate binding site [ion binding]; other site 479435006567 active site 479435006568 metal binding site A [ion binding]; metal-binding site 479435006569 DNA binding site [nucleotide binding] 479435006570 putative AP binding site [nucleotide binding]; other site 479435006571 putative metal binding site B [ion binding]; other site 479435006572 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435006573 DinB superfamily; Region: DinB_2; pfam12867 479435006574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435006575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435006576 active site 479435006577 catalytic tetrad [active] 479435006578 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 479435006579 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 479435006580 Active site serine [active] 479435006581 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 479435006582 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 479435006583 Sulfate transporter family; Region: Sulfate_transp; pfam00916 479435006584 Sulfate transporter family; Region: Sulfate_transp; pfam00916 479435006585 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 479435006586 active site clefts [active] 479435006587 zinc binding site [ion binding]; other site 479435006588 dimer interface [polypeptide binding]; other site 479435006589 short chain dehydrogenase; Provisional; Region: PRK06125 479435006590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006591 NAD(P) binding site [chemical binding]; other site 479435006592 active site 479435006593 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435006594 DNA binding residues [nucleotide binding] 479435006595 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435006596 Domain of unknown function (DUF427); Region: DUF427; cl00998 479435006597 Domain of unknown function (DUF427); Region: DUF427; cl00998 479435006598 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 479435006599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435006600 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435006601 putative substrate translocation pore; other site 479435006602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435006603 putative DNA binding site [nucleotide binding]; other site 479435006604 putative Zn2+ binding site [ion binding]; other site 479435006605 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435006606 dimerization interface [polypeptide binding]; other site 479435006607 UbiA prenyltransferase family; Region: UbiA; pfam01040 479435006608 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 479435006609 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 479435006610 malonyl-CoA binding site [chemical binding]; other site 479435006611 dimer interface [polypeptide binding]; other site 479435006612 active site 479435006613 product binding site; other site 479435006614 Phospholipid methyltransferase; Region: PEMT; cl17370 479435006615 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 479435006616 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479435006617 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 479435006618 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435006619 hydroxyglutarate oxidase; Provisional; Region: PRK11728 479435006620 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435006621 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479435006622 catalytic residues [active] 479435006623 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435006624 catalytic tetrad [active] 479435006625 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 479435006626 AAA-like domain; Region: AAA_10; pfam12846 479435006627 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435006628 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435006629 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 479435006630 hypothetical protein; Provisional; Region: PRK13685 479435006631 von Willebrand factor type A domain; Region: VWA_2; pfam13519 479435006632 metal ion-dependent adhesion site (MIDAS); other site 479435006633 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 479435006634 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 479435006635 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 479435006636 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 479435006637 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479435006638 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 479435006639 dimer interface [polypeptide binding]; other site 479435006640 active site 479435006641 acyl carrier protein; Provisional; Region: acpP; PRK00982 479435006642 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 479435006643 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 479435006644 dimer interface [polypeptide binding]; other site 479435006645 active site 479435006646 CoA binding pocket [chemical binding]; other site 479435006647 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 479435006648 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479435006649 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 479435006650 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479435006651 carboxyltransferase (CT) interaction site; other site 479435006652 biotinylation site [posttranslational modification]; other site 479435006653 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479435006654 hypothetical protein; Provisional; Region: PRK07945 479435006655 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 479435006656 active site 479435006657 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435006658 MarR family; Region: MarR_2; cl17246 479435006659 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 479435006660 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 479435006661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435006662 putative substrate translocation pore; other site 479435006663 POT family; Region: PTR2; cl17359 479435006664 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 479435006665 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 479435006666 dimer interface [polypeptide binding]; other site 479435006667 TPP-binding site [chemical binding]; other site 479435006668 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 479435006669 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 479435006670 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 479435006671 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 479435006672 dimer interface [polypeptide binding]; other site 479435006673 catalytic triad [active] 479435006674 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479435006675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435006676 acyl-activating enzyme (AAE) consensus motif; other site 479435006677 AMP binding site [chemical binding]; other site 479435006678 active site 479435006679 CoA binding site [chemical binding]; other site 479435006680 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479435006681 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479435006682 active site 479435006683 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 479435006684 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435006685 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435006686 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435006687 acyl-activating enzyme (AAE) consensus motif; other site 479435006688 AMP binding site [chemical binding]; other site 479435006689 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435006690 ROK family; Region: ROK; pfam00480 479435006691 nucleotide binding site [chemical binding]; other site 479435006692 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 479435006693 active site 479435006694 catalytic site [active] 479435006695 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 479435006696 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 479435006697 PhoD-like phosphatase; Region: PhoD; pfam09423 479435006698 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006699 putative active site [active] 479435006700 putative metal binding site [ion binding]; other site 479435006701 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006702 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435006703 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 479435006704 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 479435006705 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 479435006706 MarR family; Region: MarR_2; pfam12802 479435006707 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435006708 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435006709 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479435006710 active site 479435006711 catalytic site [active] 479435006712 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 479435006713 Uncharacterized conserved protein [Function unknown]; Region: COG0327 479435006714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 479435006715 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 479435006716 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 479435006717 Putative zinc ribbon domain; Region: DUF164; pfam02591 479435006718 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 479435006719 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 479435006720 RNA/DNA hybrid binding site [nucleotide binding]; other site 479435006721 active site 479435006722 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435006723 catalytic core [active] 479435006724 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 479435006725 RNB domain; Region: RNB; pfam00773 479435006726 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 479435006727 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435006728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435006729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435006730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006731 Coenzyme A binding pocket [chemical binding]; other site 479435006732 Cupin domain; Region: Cupin_2; pfam07883 479435006733 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479435006734 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 479435006735 Protein of unknown function (DUF952); Region: DUF952; cl01393 479435006736 PhoD-like phosphatase; Region: PhoD; pfam09423 479435006737 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006738 putative active site [active] 479435006739 putative metal binding site [ion binding]; other site 479435006740 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006741 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 479435006742 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 479435006743 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435006744 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435006745 Coenzyme A binding pocket [chemical binding]; other site 479435006746 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435006747 active site 479435006748 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435006749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435006750 intersubunit interface [polypeptide binding]; other site 479435006751 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435006752 nudix motif; other site 479435006753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435006754 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435006755 active site 479435006756 catalytic tetrad [active] 479435006757 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 479435006758 oligomerization interface [polypeptide binding]; other site 479435006759 active site 479435006760 metal binding site [ion binding]; metal-binding site 479435006761 NAD synthetase; Provisional; Region: PRK13981 479435006762 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 479435006763 multimer interface [polypeptide binding]; other site 479435006764 active site 479435006765 catalytic triad [active] 479435006766 protein interface 1 [polypeptide binding]; other site 479435006767 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 479435006768 homodimer interface [polypeptide binding]; other site 479435006769 NAD binding pocket [chemical binding]; other site 479435006770 ATP binding pocket [chemical binding]; other site 479435006771 Mg binding site [ion binding]; other site 479435006772 active-site loop [active] 479435006773 Predicted membrane protein [Function unknown]; Region: COG2311 479435006774 Protein of unknown function (DUF418); Region: DUF418; cl12135 479435006775 Protein of unknown function (DUF418); Region: DUF418; pfam04235 479435006776 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435006777 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 479435006778 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 479435006779 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479435006780 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479435006781 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 479435006782 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 479435006783 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435006784 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 479435006785 active site 479435006786 metal binding site [ion binding]; metal-binding site 479435006787 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435006788 active site 479435006789 metal binding site [ion binding]; metal-binding site 479435006790 PQQ-like domain; Region: PQQ_2; pfam13360 479435006791 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 479435006792 Trp docking motif [polypeptide binding]; other site 479435006793 active site 479435006794 PQQ-like domain; Region: PQQ_2; pfam13360 479435006795 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479435006796 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 479435006797 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479435006798 metal binding triad; other site 479435006799 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479435006800 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479435006801 metal binding triad; other site 479435006802 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479435006803 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435006804 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435006806 DNA binding residues [nucleotide binding] 479435006807 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435006808 S-adenosylmethionine binding site [chemical binding]; other site 479435006809 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435006810 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 479435006811 NMT1-like family; Region: NMT1_2; pfam13379 479435006812 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 479435006813 substrate binding pocket [chemical binding]; other site 479435006814 membrane-bound complex binding site; other site 479435006815 hinge residues; other site 479435006816 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 479435006817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435006818 Walker A/P-loop; other site 479435006819 ATP binding site [chemical binding]; other site 479435006820 Q-loop/lid; other site 479435006821 ABC transporter signature motif; other site 479435006822 Walker B; other site 479435006823 D-loop; other site 479435006824 H-loop/switch region; other site 479435006825 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479435006826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435006827 dimer interface [polypeptide binding]; other site 479435006828 conserved gate region; other site 479435006829 putative PBP binding loops; other site 479435006830 ABC-ATPase subunit interface; other site 479435006831 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 479435006832 Transcription factor WhiB; Region: Whib; pfam02467 479435006833 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 479435006834 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435006835 DNA binding residues [nucleotide binding] 479435006836 B12 binding domain; Region: B12-binding_2; pfam02607 479435006837 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 479435006838 CrcB-like protein; Region: CRCB; pfam02537 479435006839 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435006840 catalytic core [active] 479435006841 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 479435006842 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 479435006843 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 479435006844 Phosphoesterase family; Region: Phosphoesterase; pfam04185 479435006845 Domain of unknown function (DUF756); Region: DUF756; pfam05506 479435006846 Domain of unknown function (DUF756); Region: DUF756; pfam05506 479435006847 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 479435006848 putative deacylase active site [active] 479435006849 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 479435006850 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435006851 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 479435006852 GTP cyclohydrolase I; Provisional; Region: PLN03044 479435006853 active site 479435006854 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 479435006855 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 479435006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435006857 S-adenosylmethionine binding site [chemical binding]; other site 479435006858 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 479435006859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435006860 Walker A/P-loop; other site 479435006861 ATP binding site [chemical binding]; other site 479435006862 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 479435006863 active site 479435006864 metal binding site [ion binding]; metal-binding site 479435006865 Helix-Turn-Helix DNA binding domain of the MerR1 transcription regulator; Region: HTH_MerR1; cd04783 479435006866 Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051 479435006867 DNA binding residues [nucleotide binding] 479435006868 dimer interface [polypeptide binding]; other site 479435006869 mercury binding site [ion binding]; other site 479435006870 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 479435006871 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435006872 substrate binding site [chemical binding]; other site 479435006873 ATP binding site [chemical binding]; other site 479435006874 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 479435006875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435006876 S-adenosylmethionine binding site [chemical binding]; other site 479435006877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435006878 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 479435006879 Walker A/P-loop; other site 479435006880 ATP binding site [chemical binding]; other site 479435006881 Q-loop/lid; other site 479435006882 ABC transporter signature motif; other site 479435006883 Walker B; other site 479435006884 D-loop; other site 479435006885 H-loop/switch region; other site 479435006886 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435006887 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435006888 Predicted membrane protein [Function unknown]; Region: COG4709 479435006889 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria; Region: NTP-PPase_u1; cd11538 479435006890 metal binding site [ion binding]; metal-binding site 479435006891 PhoD-like phosphatase; Region: PhoD; pfam09423 479435006892 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435006893 putative active site [active] 479435006894 putative metal binding site [ion binding]; other site 479435006895 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435006896 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; pfam03663 479435006897 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 479435006898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435006899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435006900 non-specific DNA binding site [nucleotide binding]; other site 479435006901 salt bridge; other site 479435006902 sequence-specific DNA binding site [nucleotide binding]; other site 479435006903 glutamine synthetase, type I; Region: GlnA; TIGR00653 479435006904 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 479435006905 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 479435006906 RDD family; Region: RDD; pfam06271 479435006907 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 479435006908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435006909 S-adenosylmethionine binding site [chemical binding]; other site 479435006910 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435006911 putative dimer interface [polypeptide binding]; other site 479435006912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435006913 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 479435006914 lipoyl synthase; Provisional; Region: PRK05481 479435006915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435006916 FeS/SAM binding site; other site 479435006917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435006918 Histidine kinase; Region: HisKA_3; pfam07730 479435006919 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435006920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435006921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435006922 active site 479435006923 phosphorylation site [posttranslational modification] 479435006924 intermolecular recognition site; other site 479435006925 dimerization interface [polypeptide binding]; other site 479435006926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435006927 DNA binding residues [nucleotide binding] 479435006928 dimerization interface [polypeptide binding]; other site 479435006929 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435006930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435006931 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435006932 DNA binding residues [nucleotide binding] 479435006933 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 479435006934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435006935 Walker A/P-loop; other site 479435006936 ATP binding site [chemical binding]; other site 479435006937 Q-loop/lid; other site 479435006938 ABC transporter signature motif; other site 479435006939 Walker B; other site 479435006940 D-loop; other site 479435006941 H-loop/switch region; other site 479435006942 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 479435006943 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 479435006944 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435006945 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435006946 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435006947 putative dimerization interface [polypeptide binding]; other site 479435006948 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 479435006949 ribonuclease E; Reviewed; Region: rne; PRK10811 479435006950 lipoate-protein ligase B; Provisional; Region: PRK14345 479435006951 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435006952 active site 479435006953 ATP binding site [chemical binding]; other site 479435006954 substrate binding site [chemical binding]; other site 479435006955 Domain of unknown function (DUF222); Region: DUF222; pfam02720 479435006956 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479435006957 active site 479435006958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435006959 TIGR01777 family protein; Region: yfcH 479435006960 NAD(P) binding site [chemical binding]; other site 479435006961 active site 479435006962 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435006963 E3 interaction surface; other site 479435006964 lipoyl attachment site [posttranslational modification]; other site 479435006965 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435006966 E3 interaction surface; other site 479435006967 lipoyl attachment site [posttranslational modification]; other site 479435006968 e3 binding domain; Region: E3_binding; pfam02817 479435006969 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 479435006970 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479435006971 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 479435006972 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435006973 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435006974 multifunctional aminopeptidase A; Provisional; Region: PRK00913 479435006975 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 479435006976 interface (dimer of trimers) [polypeptide binding]; other site 479435006977 Substrate-binding/catalytic site; other site 479435006978 Zn-binding sites [ion binding]; other site 479435006979 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 479435006980 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 479435006981 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435006982 DNA binding site [nucleotide binding] 479435006983 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435006984 NB-ARC domain; Region: NB-ARC; pfam00931 479435006985 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435006986 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435006987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435006988 dimer interface [polypeptide binding]; other site 479435006989 conserved gate region; other site 479435006990 putative PBP binding loops; other site 479435006991 ABC-ATPase subunit interface; other site 479435006992 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435006993 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 479435006994 peptide binding site [polypeptide binding]; other site 479435006995 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435006996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435006997 dimer interface [polypeptide binding]; other site 479435006998 conserved gate region; other site 479435006999 putative PBP binding loops; other site 479435007000 ABC-ATPase subunit interface; other site 479435007001 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435007002 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435007003 Walker A/P-loop; other site 479435007004 ATP binding site [chemical binding]; other site 479435007005 Q-loop/lid; other site 479435007006 ABC transporter signature motif; other site 479435007007 Walker B; other site 479435007008 D-loop; other site 479435007009 H-loop/switch region; other site 479435007010 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435007011 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479435007012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435007013 Walker A/P-loop; other site 479435007014 ATP binding site [chemical binding]; other site 479435007015 Q-loop/lid; other site 479435007016 ABC transporter signature motif; other site 479435007017 Walker B; other site 479435007018 D-loop; other site 479435007019 H-loop/switch region; other site 479435007020 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479435007021 DNA polymerase III subunit beta; Validated; Region: PRK07761 479435007022 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 479435007023 putative DNA binding surface [nucleotide binding]; other site 479435007024 dimer interface [polypeptide binding]; other site 479435007025 beta-clamp/translesion DNA polymerase binding surface; other site 479435007026 beta-clamp/clamp loader binding surface; other site 479435007027 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 479435007028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435007029 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435007030 TM-ABC transporter signature motif; other site 479435007031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435007032 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435007033 Walker A/P-loop; other site 479435007034 ATP binding site [chemical binding]; other site 479435007035 Q-loop/lid; other site 479435007036 ABC transporter signature motif; other site 479435007037 Walker B; other site 479435007038 D-loop; other site 479435007039 H-loop/switch region; other site 479435007040 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 479435007041 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479435007042 putative ligand binding site [chemical binding]; other site 479435007043 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 479435007044 non-specific DNA interactions [nucleotide binding]; other site 479435007045 DNA binding site [nucleotide binding] 479435007046 sequence specific DNA binding site [nucleotide binding]; other site 479435007047 putative cAMP binding site [chemical binding]; other site 479435007048 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435007049 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435007050 cobalamin synthase; Reviewed; Region: cobS; PRK00235 479435007051 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 479435007052 homotrimer interface [polypeptide binding]; other site 479435007053 Walker A motif; other site 479435007054 GTP binding site [chemical binding]; other site 479435007055 Walker B motif; other site 479435007056 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 479435007057 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 479435007058 Walker A/P-loop; other site 479435007059 ATP binding site [chemical binding]; other site 479435007060 Q-loop/lid; other site 479435007061 ABC transporter signature motif; other site 479435007062 Walker B; other site 479435007063 D-loop; other site 479435007064 H-loop/switch region; other site 479435007065 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435007066 Walker A/P-loop; other site 479435007067 ATP binding site [chemical binding]; other site 479435007068 Q-loop/lid; other site 479435007069 ABC transporter signature motif; other site 479435007070 Walker B; other site 479435007071 D-loop; other site 479435007072 H-loop/switch region; other site 479435007073 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435007074 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435007075 active site 479435007076 catalytic tetrad [active] 479435007077 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 479435007078 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 479435007079 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479435007080 Bacterial sugar transferase; Region: Bac_transf; pfam02397 479435007081 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 479435007082 active site 479435007083 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479435007084 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435007085 Active Sites [active] 479435007086 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 479435007087 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 479435007088 CysD dimerization site [polypeptide binding]; other site 479435007089 G1 box; other site 479435007090 putative GEF interaction site [polypeptide binding]; other site 479435007091 GTP/Mg2+ binding site [chemical binding]; other site 479435007092 Switch I region; other site 479435007093 G2 box; other site 479435007094 G3 box; other site 479435007095 Switch II region; other site 479435007096 G4 box; other site 479435007097 G5 box; other site 479435007098 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 479435007099 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 479435007100 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 479435007101 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 479435007102 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 479435007103 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435007104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435007105 S-adenosylmethionine binding site [chemical binding]; other site 479435007106 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435007107 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435007108 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435007109 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435007110 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435007111 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435007112 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435007113 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435007114 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435007115 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 479435007116 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 479435007117 Chain length determinant protein; Region: Wzz; pfam02706 479435007118 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 479435007119 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435007120 active site 479435007121 Chain length determinant protein; Region: Wzz; cl15801 479435007122 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 479435007123 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435007124 FOG: PKD repeat [General function prediction only]; Region: COG3291 479435007125 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435007126 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435007127 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435007128 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl17353 479435007129 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 479435007130 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 479435007131 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435007132 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435007133 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 479435007134 ligand-binding site [chemical binding]; other site 479435007135 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 479435007136 Bacterial sugar transferase; Region: Bac_transf; pfam02397 479435007137 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 479435007138 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 479435007139 NADP binding site [chemical binding]; other site 479435007140 active site 479435007141 putative substrate binding site [chemical binding]; other site 479435007142 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 479435007143 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 479435007144 NADP-binding site; other site 479435007145 homotetramer interface [polypeptide binding]; other site 479435007146 substrate binding site [chemical binding]; other site 479435007147 homodimer interface [polypeptide binding]; other site 479435007148 active site 479435007149 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 479435007150 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 479435007151 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_11; cd13126 479435007152 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435007153 PQQ-like domain; Region: PQQ_2; pfam13360 479435007154 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479435007155 Chain length determinant protein; Region: Wzz; pfam02706 479435007156 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 479435007157 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 479435007158 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479435007159 classical (c) SDRs; Region: SDR_c; cd05233 479435007160 NAD(P) binding site [chemical binding]; other site 479435007161 active site 479435007162 Right handed beta helix region; Region: Beta_helix; pfam13229 479435007163 glucuronate isomerase; Reviewed; Region: PRK02925 479435007164 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 479435007165 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435007166 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435007167 DNA binding site [nucleotide binding] 479435007168 domain linker motif; other site 479435007169 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435007170 dimerization interface [polypeptide binding]; other site 479435007171 ligand binding site [chemical binding]; other site 479435007172 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479435007173 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479435007174 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479435007175 Right handed beta helix region; Region: Beta_helix; pfam13229 479435007176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435007177 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 479435007178 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435007179 active site 479435007180 HIGH motif; other site 479435007181 nucleotide binding site [chemical binding]; other site 479435007182 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 479435007183 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435007184 active site 479435007185 nucleotide binding site [chemical binding]; other site 479435007186 HIGH motif; other site 479435007187 KMSKS motif; other site 479435007188 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 479435007189 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435007190 quinolinate synthetase; Provisional; Region: PRK09375 479435007191 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 479435007192 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435007193 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 479435007194 nudix motif; other site 479435007195 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 479435007196 Active_site [active] 479435007197 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 479435007198 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 479435007199 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 479435007200 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 479435007201 metal binding site [ion binding]; metal-binding site 479435007202 dimer interface [polypeptide binding]; other site 479435007203 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435007204 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435007205 RibD C-terminal domain; Region: RibD_C; cl17279 479435007206 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435007207 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 479435007208 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 479435007209 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435007210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435007211 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435007212 DoxX-like family; Region: DoxX_2; pfam13564 479435007213 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479435007214 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 479435007215 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435007216 active site 479435007217 catalytic site [active] 479435007218 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479435007219 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 479435007220 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 479435007221 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 479435007222 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 479435007223 Ca binding site [ion binding]; other site 479435007224 active site 479435007225 catalytic site [active] 479435007226 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 479435007227 NAD-dependent deacetylase; Provisional; Region: PRK00481 479435007228 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 479435007229 NAD+ binding site [chemical binding]; other site 479435007230 substrate binding site [chemical binding]; other site 479435007231 Zn binding site [ion binding]; other site 479435007232 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435007233 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435007234 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 479435007235 CPxP motif; other site 479435007236 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435007237 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 479435007238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007239 catalytic residue [active] 479435007240 cytochrome c oxidase subunit II; Provisional; Region: COX2; MTH00140 479435007241 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 479435007242 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 479435007243 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 479435007244 D-pathway; other site 479435007245 Putative ubiquinol binding site [chemical binding]; other site 479435007246 Low-spin heme (heme b) binding site [chemical binding]; other site 479435007247 Putative water exit pathway; other site 479435007248 Binuclear center (heme o3/CuB) [ion binding]; other site 479435007249 K-pathway; other site 479435007250 Putative proton exit pathway; other site 479435007251 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 479435007252 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 479435007253 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 479435007254 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 479435007255 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435007256 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435007257 YCII-related domain; Region: YCII; cl00999 479435007258 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479435007259 heme bH binding site [chemical binding]; other site 479435007260 Qi binding site; other site 479435007261 intrachain domain interface; other site 479435007262 heme bL binding site [chemical binding]; other site 479435007263 interchain domain interface [polypeptide binding]; other site 479435007264 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 479435007265 Qo binding site; other site 479435007266 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 479435007267 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 479435007268 iron-sulfur cluster [ion binding]; other site 479435007269 [2Fe-2S] cluster binding site [ion binding]; other site 479435007270 cytochrome c-550; Provisional; Region: psbV; cl17239 479435007271 Cytochrome c; Region: Cytochrom_C; pfam00034 479435007272 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 479435007273 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 479435007274 Subunit I/III interface [polypeptide binding]; other site 479435007275 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 479435007276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 479435007277 active site 479435007278 phosphorylation site [posttranslational modification] 479435007279 intermolecular recognition site; other site 479435007280 dimerization interface [polypeptide binding]; other site 479435007281 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 479435007282 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 479435007283 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 479435007284 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 479435007285 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435007286 AsnC family; Region: AsnC_trans_reg; pfam01037 479435007287 hypothetical protein; Validated; Region: PRK07883 479435007288 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 479435007289 active site 479435007290 catalytic site [active] 479435007291 substrate binding site [chemical binding]; other site 479435007292 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 479435007293 GIY-YIG motif/motif A; other site 479435007294 active site 479435007295 catalytic site [active] 479435007296 putative DNA binding site [nucleotide binding]; other site 479435007297 metal binding site [ion binding]; metal-binding site 479435007298 Protein of unknown function (DUF972); Region: DUF972; pfam06156 479435007299 YacP-like NYN domain; Region: NYN_YacP; cl01491 479435007300 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479435007301 NlpC/P60 family; Region: NLPC_P60; pfam00877 479435007302 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 479435007303 Peptidase family M48; Region: Peptidase_M48; cl12018 479435007304 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435007305 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435007306 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 479435007307 motif 1; other site 479435007308 active site 479435007309 motif 2; other site 479435007310 motif 3; other site 479435007311 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435007312 EamA-like transporter family; Region: EamA; pfam00892 479435007313 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 479435007314 putative DNA binding site [nucleotide binding]; other site 479435007315 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435007316 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 479435007317 Isochorismatase family; Region: Isochorismatase; pfam00857 479435007318 catalytic triad [active] 479435007319 conserved cis-peptide bond; other site 479435007320 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435007321 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435007322 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435007323 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435007324 DNA binding residues [nucleotide binding] 479435007325 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435007326 AAA domain; Region: AAA_17; pfam13207 479435007327 AAA domain; Region: AAA_18; pfam13238 479435007328 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435007329 active site 479435007330 Isochorismatase family; Region: Isochorismatase; pfam00857 479435007331 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 479435007332 catalytic triad [active] 479435007333 conserved cis-peptide bond; other site 479435007334 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 479435007335 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 479435007336 acyl-activating enzyme (AAE) consensus motif; other site 479435007337 putative AMP binding site [chemical binding]; other site 479435007338 putative active site [active] 479435007339 putative CoA binding site [chemical binding]; other site 479435007340 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 479435007341 putative hydrophobic ligand binding site [chemical binding]; other site 479435007342 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 479435007343 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 479435007344 DTAP/Switch II; other site 479435007345 Switch I; other site 479435007346 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 479435007347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435007348 nucleotide binding site [chemical binding]; other site 479435007349 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 479435007350 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435007351 nucleotide binding site [chemical binding]; other site 479435007352 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435007353 putative metal binding site [ion binding]; other site 479435007354 putative catalytic site [active] 479435007355 putative phosphate binding site [ion binding]; other site 479435007356 putative metal binding site [ion binding]; other site 479435007357 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12748 479435007358 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007359 NAD(P) binding site [chemical binding]; other site 479435007360 active site 479435007361 enoyl-CoA hydratase; Provisional; Region: PRK07827 479435007362 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435007363 substrate binding site [chemical binding]; other site 479435007364 oxyanion hole (OAH) forming residues; other site 479435007365 trimer interface [polypeptide binding]; other site 479435007366 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435007367 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435007368 active site 479435007369 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 479435007370 Uncharacterized conserved protein [Function unknown]; Region: COG1915 479435007371 homodimer interface [polypeptide binding]; other site 479435007372 Esterase/lipase [General function prediction only]; Region: COG1647 479435007373 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 479435007374 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435007375 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435007376 putative acyl-acceptor binding pocket; other site 479435007377 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 479435007378 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 479435007379 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435007380 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 479435007381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007382 catalytic residue [active] 479435007383 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 479435007384 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 479435007385 Phosphotransferase enzyme family; Region: APH; pfam01636 479435007386 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 479435007387 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 479435007388 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435007389 active site 479435007390 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 479435007391 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 479435007392 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435007393 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435007394 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435007395 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 479435007396 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435007397 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 479435007398 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435007399 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435007400 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435007401 active site 479435007402 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435007403 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435007404 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435007405 DNA binding residues [nucleotide binding] 479435007406 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 479435007407 oligosaccharide amylase; Region: oligosac_amyl; TIGR01577 479435007408 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435007409 EamA-like transporter family; Region: EamA; pfam00892 479435007410 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435007411 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435007412 active site 479435007413 ATP binding site [chemical binding]; other site 479435007414 substrate binding site [chemical binding]; other site 479435007415 activation loop (A-loop); other site 479435007416 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435007417 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435007418 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435007419 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435007420 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 479435007421 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479435007422 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479435007423 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 479435007424 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479435007425 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435007426 catalytic residue [active] 479435007427 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 479435007428 ThiS interaction site; other site 479435007429 putative active site [active] 479435007430 tetramer interface [polypeptide binding]; other site 479435007431 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 479435007432 thiS-thiF/thiG interaction site; other site 479435007433 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 479435007434 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 479435007435 thiamine phosphate binding site [chemical binding]; other site 479435007436 active site 479435007437 pyrophosphate binding site [ion binding]; other site 479435007438 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 479435007439 active site 479435007440 barstar interaction site; other site 479435007441 Barstar (barnase inhibitor); Region: Barstar; pfam01337 479435007442 RNAase interaction site [polypeptide binding]; other site 479435007443 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 479435007444 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 479435007445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435007446 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 479435007447 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435007448 DNA binding residues [nucleotide binding] 479435007449 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435007450 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435007451 substrate binding pocket [chemical binding]; other site 479435007452 chain length determination region; other site 479435007453 substrate-Mg2+ binding site; other site 479435007454 catalytic residues [active] 479435007455 aspartate-rich region 1; other site 479435007456 active site lid residues [active] 479435007457 aspartate-rich region 2; other site 479435007458 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 479435007459 FAD binding site [chemical binding]; other site 479435007460 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435007461 catalytic core [active] 479435007462 PhoH-like protein; Region: PhoH; cl17668 479435007463 Family description; Region: UvrD_C_2; pfam13538 479435007464 phytoene desaturase; Region: crtI_fam; TIGR02734 479435007465 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 479435007466 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 479435007467 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 479435007468 amidase catalytic site [active] 479435007469 Zn binding residues [ion binding]; other site 479435007470 substrate binding site [chemical binding]; other site 479435007471 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 479435007472 putative deacylase active site [active] 479435007473 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 479435007474 Electron transfer DM13; Region: DM13; pfam10517 479435007475 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435007476 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 479435007477 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435007478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435007479 S-adenosylmethionine binding site [chemical binding]; other site 479435007480 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 479435007481 Protein of unknown function (DUF4106); Region: DUF4106; pfam13388 479435007482 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 479435007483 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479435007484 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 479435007485 Protein of unknown function DUF58; Region: DUF58; pfam01882 479435007486 MoxR-like ATPases [General function prediction only]; Region: COG0714 479435007487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435007488 Walker A motif; other site 479435007489 ATP binding site [chemical binding]; other site 479435007490 Walker B motif; other site 479435007491 arginine finger; other site 479435007492 cell division protein MraZ; Reviewed; Region: PRK00326 479435007493 MraZ protein; Region: MraZ; pfam02381 479435007494 MraZ protein; Region: MraZ; pfam02381 479435007495 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 479435007496 MraW methylase family; Region: Methyltransf_5; cl17771 479435007497 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 479435007498 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479435007499 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 479435007500 DNA methylase; Region: N6_N4_Mtase; cl17433 479435007501 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435007502 S-adenosylmethionine binding site [chemical binding]; other site 479435007503 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 479435007504 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479435007505 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435007506 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435007507 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 479435007508 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479435007509 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435007510 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435007511 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 479435007512 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 479435007513 Mg++ binding site [ion binding]; other site 479435007514 putative catalytic motif [active] 479435007515 putative substrate binding site [chemical binding]; other site 479435007516 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 479435007517 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435007518 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435007519 cell division protein FtsW; Region: ftsW; TIGR02614 479435007520 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 479435007521 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 479435007522 active site 479435007523 homodimer interface [polypeptide binding]; other site 479435007524 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 479435007525 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 479435007526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435007527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435007528 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 479435007529 Cell division protein FtsQ; Region: FtsQ; pfam03799 479435007530 Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206 479435007531 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 479435007532 nucleotide binding site [chemical binding]; other site 479435007533 SulA interaction site; other site 479435007534 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 479435007535 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 479435007536 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 479435007537 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435007538 catalytic residue [active] 479435007539 Protein of unknown function (DUF552); Region: DUF552; cl00775 479435007540 DivIVA domain; Region: DivI1A_domain; TIGR03544 479435007541 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435007542 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 479435007543 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 479435007544 HIGH motif; other site 479435007545 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 479435007546 active site 479435007547 KMSKS motif; other site 479435007548 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 479435007549 tRNA binding surface [nucleotide binding]; other site 479435007550 anticodon binding site; other site 479435007551 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 479435007552 lipoprotein signal peptidase; Provisional; Region: PRK14764 479435007553 lipoprotein signal peptidase; Provisional; Region: PRK14787 479435007554 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 479435007555 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479435007556 RNA binding surface [nucleotide binding]; other site 479435007557 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 479435007558 active site 479435007559 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435007560 MarR family; Region: MarR_2; pfam12802 479435007561 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435007562 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 479435007563 conserved cys residue [active] 479435007564 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435007565 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 479435007566 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 479435007567 active site 479435007568 PHP Thumb interface [polypeptide binding]; other site 479435007569 metal binding site [ion binding]; metal-binding site 479435007570 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 479435007571 generic binding surface II; other site 479435007572 generic binding surface I; other site 479435007573 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 479435007574 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435007575 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435007576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435007577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435007578 putative substrate translocation pore; other site 479435007579 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435007580 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435007581 salt bridge; other site 479435007582 non-specific DNA binding site [nucleotide binding]; other site 479435007583 sequence-specific DNA binding site [nucleotide binding]; other site 479435007584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435007585 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435007586 N-acetylmuramoyl-L-alanine amidase; Region: Amidase_2; pfam01510 479435007587 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 479435007588 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435007589 ATP binding site [chemical binding]; other site 479435007590 putative Mg++ binding site [ion binding]; other site 479435007591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435007592 nucleotide binding region [chemical binding]; other site 479435007593 ATP-binding site [chemical binding]; other site 479435007594 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 479435007595 HRDC domain; Region: HRDC; pfam00570 479435007596 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435007597 active site 479435007598 catalytic residues [active] 479435007599 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479435007600 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479435007601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435007602 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 479435007603 Growth inhibitor [Signal transduction mechanisms]; Region: MazF; COG2337 479435007604 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 479435007605 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 479435007606 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 479435007607 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 479435007608 NAD binding site [chemical binding]; other site 479435007609 dimerization interface [polypeptide binding]; other site 479435007610 product binding site; other site 479435007611 substrate binding site [chemical binding]; other site 479435007612 zinc binding site [ion binding]; other site 479435007613 catalytic residues [active] 479435007614 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 479435007615 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435007616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435007617 homodimer interface [polypeptide binding]; other site 479435007618 catalytic residue [active] 479435007619 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 479435007620 putative active site pocket [active] 479435007621 4-fold oligomerization interface [polypeptide binding]; other site 479435007622 metal binding residues [ion binding]; metal-binding site 479435007623 3-fold/trimer interface [polypeptide binding]; other site 479435007624 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 479435007625 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 479435007626 putative active site [active] 479435007627 oxyanion strand; other site 479435007628 catalytic triad [active] 479435007629 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435007630 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 479435007631 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479435007632 putative ligand binding site [chemical binding]; other site 479435007633 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 479435007634 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435007635 Walker A/P-loop; other site 479435007636 ATP binding site [chemical binding]; other site 479435007637 Q-loop/lid; other site 479435007638 ABC transporter signature motif; other site 479435007639 Walker B; other site 479435007640 D-loop; other site 479435007641 H-loop/switch region; other site 479435007642 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479435007643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435007644 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435007645 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435007646 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435007647 TM-ABC transporter signature motif; other site 479435007648 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435007649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435007650 DNA binding site [nucleotide binding] 479435007651 domain linker motif; other site 479435007652 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 479435007653 ligand binding site [chemical binding]; other site 479435007654 dimerization interface (open form) [polypeptide binding]; other site 479435007655 dimerization interface (closed form) [polypeptide binding]; other site 479435007656 hypothetical protein; Provisional; Region: PRK07206 479435007657 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 479435007658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435007659 putative substrate translocation pore; other site 479435007660 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435007661 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 479435007662 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435007663 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 479435007664 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435007665 tRNA synthetases class I (M); Region: tRNA-synt_1g; pfam09334 479435007666 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435007667 active site 479435007668 HIGH motif; other site 479435007669 nucleotide binding site [chemical binding]; other site 479435007670 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435007671 active site 479435007672 KMSKS motif; other site 479435007673 Cupin domain; Region: Cupin_2; pfam07883 479435007674 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435007675 dinuclear metal binding motif [ion binding]; other site 479435007676 ribosome maturation protein RimP; Reviewed; Region: PRK00092 479435007677 Sm and related proteins; Region: Sm_like; cl00259 479435007678 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 479435007679 putative oligomer interface [polypeptide binding]; other site 479435007680 putative RNA binding site [nucleotide binding]; other site 479435007681 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 479435007682 NusA N-terminal domain; Region: NusA_N; pfam08529 479435007683 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 479435007684 RNA binding site [nucleotide binding]; other site 479435007685 homodimer interface [polypeptide binding]; other site 479435007686 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 479435007687 G-X-X-G motif; other site 479435007688 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 479435007689 G-X-X-G motif; other site 479435007690 Protein of unknown function (DUF448); Region: DUF448; pfam04296 479435007691 putative RNA binding cleft [nucleotide binding]; other site 479435007692 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 479435007693 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 479435007694 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 479435007695 G1 box; other site 479435007696 putative GEF interaction site [polypeptide binding]; other site 479435007697 GTP/Mg2+ binding site [chemical binding]; other site 479435007698 Switch I region; other site 479435007699 G2 box; other site 479435007700 G3 box; other site 479435007701 Switch II region; other site 479435007702 G4 box; other site 479435007703 G5 box; other site 479435007704 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 479435007705 Translation-initiation factor 2; Region: IF-2; pfam11987 479435007706 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 479435007707 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 479435007708 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 479435007709 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 479435007710 RNA binding site [nucleotide binding]; other site 479435007711 active site 479435007712 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 479435007713 Phosphotransferase enzyme family; Region: APH; pfam01636 479435007714 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435007715 active site 479435007716 ATP binding site [chemical binding]; other site 479435007717 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 479435007718 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479435007719 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 479435007720 active site 479435007721 putative catalytic site [active] 479435007722 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 479435007723 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 479435007724 NAD+ binding site [chemical binding]; other site 479435007725 substrate binding site [chemical binding]; other site 479435007726 Zn binding site [ion binding]; other site 479435007727 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 479435007728 active site 479435007729 catalytic triad [active] 479435007730 oxyanion hole [active] 479435007731 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 479435007732 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 479435007733 active site 479435007734 Riboflavin kinase; Region: Flavokinase; smart00904 479435007735 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 479435007736 16S/18S rRNA binding site [nucleotide binding]; other site 479435007737 S13e-L30e interaction site [polypeptide binding]; other site 479435007738 25S rRNA binding site [nucleotide binding]; other site 479435007739 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 479435007740 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 479435007741 oligomer interface [polypeptide binding]; other site 479435007742 RNA binding site [nucleotide binding]; other site 479435007743 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 479435007744 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 479435007745 RNase E interface [polypeptide binding]; other site 479435007746 trimer interface [polypeptide binding]; other site 479435007747 active site 479435007748 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 479435007749 putative nucleic acid binding region [nucleotide binding]; other site 479435007750 G-X-X-G motif; other site 479435007751 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 479435007752 RNA binding site [nucleotide binding]; other site 479435007753 domain interface; other site 479435007754 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479435007755 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479435007756 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435007757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435007758 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435007759 Walker A/P-loop; other site 479435007760 ATP binding site [chemical binding]; other site 479435007761 Q-loop/lid; other site 479435007762 ABC transporter signature motif; other site 479435007763 Walker B; other site 479435007764 D-loop; other site 479435007765 H-loop/switch region; other site 479435007766 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 479435007767 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435007768 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435007769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435007770 dimer interface [polypeptide binding]; other site 479435007771 conserved gate region; other site 479435007772 putative PBP binding loops; other site 479435007773 ABC-ATPase subunit interface; other site 479435007774 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 479435007775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435007776 dimer interface [polypeptide binding]; other site 479435007777 conserved gate region; other site 479435007778 putative PBP binding loops; other site 479435007779 ABC-ATPase subunit interface; other site 479435007780 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435007781 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435007782 Walker A/P-loop; other site 479435007783 ATP binding site [chemical binding]; other site 479435007784 Q-loop/lid; other site 479435007785 ABC transporter signature motif; other site 479435007786 Walker B; other site 479435007787 D-loop; other site 479435007788 H-loop/switch region; other site 479435007789 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435007790 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479435007791 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435007792 Walker A/P-loop; other site 479435007793 ATP binding site [chemical binding]; other site 479435007794 Q-loop/lid; other site 479435007795 ABC transporter signature motif; other site 479435007796 Walker B; other site 479435007797 D-loop; other site 479435007798 H-loop/switch region; other site 479435007799 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435007800 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435007801 Coenzyme A binding pocket [chemical binding]; other site 479435007802 dihydrodipicolinate reductase; Provisional; Region: PRK00048 479435007803 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 479435007804 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 479435007805 TPR motif; other site 479435007806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 479435007807 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435007808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435007809 non-specific DNA binding site [nucleotide binding]; other site 479435007810 salt bridge; other site 479435007811 sequence-specific DNA binding site [nucleotide binding]; other site 479435007812 Predicted ATPase [General function prediction only]; Region: COG3903 479435007813 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435007814 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435007815 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435007816 TPR motif; other site 479435007817 binding surface 479435007818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435007819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435007820 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435007821 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435007822 DinB superfamily; Region: DinB_2; pfam12867 479435007823 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435007824 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435007825 putative NAD(P) binding site [chemical binding]; other site 479435007826 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435007827 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435007828 conserved cys residue [active] 479435007829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435007830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435007831 Coenzyme A binding pocket [chemical binding]; other site 479435007832 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 479435007833 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 479435007834 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 479435007835 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 479435007836 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 479435007837 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 479435007838 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 479435007839 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 479435007840 FAD binding pocket [chemical binding]; other site 479435007841 FAD binding motif [chemical binding]; other site 479435007842 phosphate binding motif [ion binding]; other site 479435007843 beta-alpha-beta structure motif; other site 479435007844 NAD(p) ribose binding residues [chemical binding]; other site 479435007845 NAD binding pocket [chemical binding]; other site 479435007846 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 479435007847 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435007848 catalytic loop [active] 479435007849 iron binding site [ion binding]; other site 479435007850 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435007851 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 479435007852 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 479435007853 Leucine rich repeat; Region: LRR_8; pfam13855 479435007854 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 479435007855 Leucine rich repeat; Region: LRR_8; pfam13855 479435007856 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 479435007857 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 479435007858 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435007859 dimer interface [polypeptide binding]; other site 479435007860 active site 479435007861 catalytic residue [active] 479435007862 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 479435007863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435007864 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 479435007865 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435007866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435007867 DNA binding site [nucleotide binding] 479435007868 domain linker motif; other site 479435007869 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435007870 dimerization interface [polypeptide binding]; other site 479435007871 ligand binding site [chemical binding]; other site 479435007872 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 479435007873 Fatty acid desaturase; Region: FA_desaturase; pfam00487 479435007874 putative di-iron ligands [ion binding]; other site 479435007875 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 479435007876 Fibronectin type 3 domain; Region: FN3; smart00060 479435007877 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435007878 putative active site [active] 479435007879 putative metal binding site [ion binding]; other site 479435007880 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435007881 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479435007882 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435007883 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435007884 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435007885 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435007886 catalytic residue [active] 479435007887 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435007888 Domain of unknown function (DUF4184); Region: DUF4184; pfam13803 479435007889 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 479435007890 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 479435007891 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435007892 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 479435007893 Helix-turn-helix domain; Region: HTH_25; pfam13413 479435007894 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 479435007895 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 479435007896 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435007897 FeS/SAM binding site; other site 479435007898 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 479435007899 Competence-damaged protein; Region: CinA; pfam02464 479435007900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 479435007901 sequence-specific DNA binding site [nucleotide binding]; other site 479435007902 salt bridge; other site 479435007903 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 479435007904 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 479435007905 putative DNA binding site [nucleotide binding]; other site 479435007906 catalytic residue [active] 479435007907 putative H2TH interface [polypeptide binding]; other site 479435007908 putative catalytic residues [active] 479435007909 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435007910 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435007911 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435007912 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 479435007913 ATP binding site [chemical binding]; other site 479435007914 putative Mg++ binding site [ion binding]; other site 479435007915 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435007916 nucleotide binding region [chemical binding]; other site 479435007917 ATP-binding site [chemical binding]; other site 479435007918 DEAD/H associated; Region: DEAD_assoc; pfam08494 479435007919 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 479435007920 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 479435007921 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 479435007922 recombinase A; Provisional; Region: recA; PRK09354 479435007923 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 479435007924 hexamer interface [polypeptide binding]; other site 479435007925 Walker A motif; other site 479435007926 ATP binding site [chemical binding]; other site 479435007927 Walker B motif; other site 479435007928 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435007929 nudix motif; other site 479435007930 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 479435007931 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 479435007932 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 479435007933 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435007934 Zn2+ binding site [ion binding]; other site 479435007935 Mg2+ binding site [ion binding]; other site 479435007936 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435007937 YtpI-like protein; Region: YtpI; pfam14007 479435007938 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435007939 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435007940 active site 479435007941 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435007942 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 479435007943 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 479435007944 catalytic triad [active] 479435007945 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 479435007946 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 479435007947 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 479435007948 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 479435007949 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 479435007950 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 479435007951 active site 479435007952 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 479435007953 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 479435007954 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 479435007955 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 479435007956 nucleosidase; Provisional; Region: PRK05634 479435007957 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 479435007958 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435007959 putative DNA binding site [nucleotide binding]; other site 479435007960 putative Zn2+ binding site [ion binding]; other site 479435007961 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435007962 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435007963 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435007964 DNA binding residues [nucleotide binding] 479435007965 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435007966 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479435007967 catalytic residues [active] 479435007968 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 479435007969 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435007970 active site 479435007971 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435007972 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 479435007973 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435007974 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435007975 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 479435007976 active site 479435007977 Zn binding site [ion binding]; other site 479435007978 Predicted membrane protein [Function unknown]; Region: COG4270 479435007979 prolyl-tRNA synthetase; Provisional; Region: PRK09194 479435007980 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 479435007981 dimer interface [polypeptide binding]; other site 479435007982 motif 1; other site 479435007983 active site 479435007984 motif 2; other site 479435007985 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 479435007986 putative deacylase active site [active] 479435007987 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435007988 active site 479435007989 motif 3; other site 479435007990 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 479435007991 anticodon binding site; other site 479435007992 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435007993 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435007994 RibD C-terminal domain; Region: RibD_C; cl17279 479435007995 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435007996 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435007997 NAD(P) binding site [chemical binding]; other site 479435007998 active site 479435007999 hypothetical protein; Provisional; Region: PRK10621 479435008000 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435008001 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435008002 DNA binding site [nucleotide binding] 479435008003 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435008004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008005 binding surface 479435008006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008007 TPR motif; other site 479435008008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008009 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435008010 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479435008011 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 479435008012 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 479435008013 catalytic residues [active] 479435008014 fatty acyl-CoA reductase; Region: PLN02996 479435008015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008016 NAD(P) binding site [chemical binding]; other site 479435008017 active site 479435008018 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 479435008019 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 479435008020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435008021 motif II; other site 479435008022 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435008023 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435008024 NAD(P) binding site [chemical binding]; other site 479435008025 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 479435008026 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435008027 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435008028 putative acyl-acceptor binding pocket; other site 479435008029 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 479435008030 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 479435008031 substrate binding site [chemical binding]; other site 479435008032 glutamase interaction surface [polypeptide binding]; other site 479435008033 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435008034 putative DNA binding site [nucleotide binding]; other site 479435008035 putative Zn2+ binding site [ion binding]; other site 479435008036 RNA polymerase sigma factor; Provisional; Region: PRK12528 479435008037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008038 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435008039 DNA binding residues [nucleotide binding] 479435008040 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435008041 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435008042 Coenzyme A binding pocket [chemical binding]; other site 479435008043 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; pfam02113 479435008044 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 479435008045 putative substrate binding site [chemical binding]; other site 479435008046 active site 479435008047 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 479435008048 Ca binding site [ion binding]; other site 479435008049 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 479435008050 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479435008051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 479435008052 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 479435008053 TIGR03085 family protein; Region: TIGR03085 479435008054 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435008055 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435008056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435008057 Walker A/P-loop; other site 479435008058 ATP binding site [chemical binding]; other site 479435008059 Q-loop/lid; other site 479435008060 ABC transporter signature motif; other site 479435008061 Walker B; other site 479435008062 D-loop; other site 479435008063 H-loop/switch region; other site 479435008064 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435008065 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435008066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435008067 Walker A/P-loop; other site 479435008068 ATP binding site [chemical binding]; other site 479435008069 Q-loop/lid; other site 479435008070 ABC transporter signature motif; other site 479435008071 Walker B; other site 479435008072 D-loop; other site 479435008073 H-loop/switch region; other site 479435008074 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 479435008075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435008076 S-adenosylmethionine binding site [chemical binding]; other site 479435008077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435008078 Coenzyme A binding pocket [chemical binding]; other site 479435008079 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 479435008080 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 479435008081 active site 479435008082 dimer interface [polypeptide binding]; other site 479435008083 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 479435008084 anthranilate synthase component I; Provisional; Region: PRK13571 479435008085 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479435008086 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 479435008087 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 479435008088 active site 479435008089 ribulose/triose binding site [chemical binding]; other site 479435008090 phosphate binding site [ion binding]; other site 479435008091 substrate (anthranilate) binding pocket [chemical binding]; other site 479435008092 product (indole) binding pocket [chemical binding]; other site 479435008093 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 479435008094 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 479435008095 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435008096 catalytic residue [active] 479435008097 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 479435008098 substrate binding site [chemical binding]; other site 479435008099 active site 479435008100 catalytic residues [active] 479435008101 heterodimer interface [polypeptide binding]; other site 479435008102 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 479435008103 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 479435008104 Cu(I) binding site [ion binding]; other site 479435008105 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 479435008106 catalytic residues [active] 479435008107 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 479435008108 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 479435008109 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435008110 DNA binding site [nucleotide binding] 479435008111 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435008112 NACHT domain; Region: NACHT; pfam05729 479435008113 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008114 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008115 binding surface 479435008116 TPR motif; other site 479435008117 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008119 binding surface 479435008120 TPR motif; other site 479435008121 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008122 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 479435008123 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 479435008124 active site 479435008125 dimer interface [polypeptide binding]; other site 479435008126 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 479435008127 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 479435008128 active site 479435008129 FMN binding site [chemical binding]; other site 479435008130 substrate binding site [chemical binding]; other site 479435008131 3Fe-4S cluster binding site [ion binding]; other site 479435008132 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 479435008133 domain interface; other site 479435008134 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 479435008135 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435008136 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435008137 active site 479435008138 metal binding site [ion binding]; metal-binding site 479435008139 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 479435008140 pyruvate kinase; Provisional; Region: PRK06247 479435008141 domain interfaces; other site 479435008142 active site 479435008143 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 479435008144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435008145 active site 479435008146 phosphorylation site [posttranslational modification] 479435008147 intermolecular recognition site; other site 479435008148 dimerization interface [polypeptide binding]; other site 479435008149 ANTAR domain; Region: ANTAR; pfam03861 479435008150 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 479435008151 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 479435008152 dimerization interface [polypeptide binding]; other site 479435008153 ligand binding site [chemical binding]; other site 479435008154 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435008155 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 479435008156 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 479435008157 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435008158 TM-ABC transporter signature motif; other site 479435008159 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 479435008160 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 479435008161 TM-ABC transporter signature motif; other site 479435008162 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 479435008163 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 479435008164 Walker A/P-loop; other site 479435008165 ATP binding site [chemical binding]; other site 479435008166 Q-loop/lid; other site 479435008167 ABC transporter signature motif; other site 479435008168 Walker B; other site 479435008169 D-loop; other site 479435008170 H-loop/switch region; other site 479435008171 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 479435008172 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 479435008173 Walker A/P-loop; other site 479435008174 ATP binding site [chemical binding]; other site 479435008175 Q-loop/lid; other site 479435008176 ABC transporter signature motif; other site 479435008177 Walker B; other site 479435008178 D-loop; other site 479435008179 H-loop/switch region; other site 479435008180 Protein of unknown function (DUF554); Region: DUF554; pfam04474 479435008181 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435008182 CoenzymeA binding site [chemical binding]; other site 479435008183 subunit interaction site [polypeptide binding]; other site 479435008184 PHB binding site; other site 479435008185 DNA polymerase I; Provisional; Region: PRK05755 479435008186 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 479435008187 active site 479435008188 metal binding site 1 [ion binding]; metal-binding site 479435008189 putative 5' ssDNA interaction site; other site 479435008190 metal binding site 3; metal-binding site 479435008191 metal binding site 2 [ion binding]; metal-binding site 479435008192 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 479435008193 putative DNA binding site [nucleotide binding]; other site 479435008194 putative metal binding site [ion binding]; other site 479435008195 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 479435008196 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 479435008197 active site 479435008198 DNA binding site [nucleotide binding] 479435008199 catalytic site [active] 479435008200 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 479435008201 nudix motif; other site 479435008202 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 479435008203 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 479435008204 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435008205 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435008206 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435008207 S-adenosylmethionine binding site [chemical binding]; other site 479435008208 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 479435008209 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 479435008210 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435008211 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435008212 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479435008213 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 479435008214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435008215 S-adenosylmethionine binding site [chemical binding]; other site 479435008216 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435008217 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435008218 DNA binding residues [nucleotide binding] 479435008219 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 479435008220 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 479435008221 putative hydrophobic ligand binding site [chemical binding]; other site 479435008222 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435008223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435008224 Phosphotransferase enzyme family; Region: APH; pfam01636 479435008225 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435008226 active site 479435008227 ATP binding site [chemical binding]; other site 479435008228 substrate binding site [chemical binding]; other site 479435008229 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 479435008230 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 479435008231 RNA binding site [nucleotide binding]; other site 479435008232 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 479435008233 RNA binding site [nucleotide binding]; other site 479435008234 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 479435008235 RNA binding site [nucleotide binding]; other site 479435008236 S1 RNA binding domain; Region: S1; pfam00575 479435008237 RNA binding site [nucleotide binding]; other site 479435008238 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435008239 AAA ATPase domain; Region: AAA_16; pfam13191 479435008240 TPR repeat; Region: TPR_11; pfam13414 479435008241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008242 binding surface 479435008243 TPR motif; other site 479435008244 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008246 binding surface 479435008247 TPR motif; other site 479435008248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435008249 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 479435008250 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 479435008251 CoA-binding site [chemical binding]; other site 479435008252 ATP-binding [chemical binding]; other site 479435008253 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 479435008254 Double zinc ribbon; Region: DZR; pfam12773 479435008255 Protease prsW family; Region: PrsW-protease; pfam13367 479435008256 excinuclease ABC subunit B; Provisional; Region: PRK05298 479435008257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435008258 putative Mg++ binding site [ion binding]; other site 479435008259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435008260 nucleotide binding region [chemical binding]; other site 479435008261 ATP-binding site [chemical binding]; other site 479435008262 Ultra-violet resistance protein B; Region: UvrB; pfam12344 479435008263 UvrB/uvrC motif; Region: UVR; pfam02151 479435008264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 479435008265 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 479435008266 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479435008267 NlpC/P60 family; Region: NLPC_P60; cl17555 479435008268 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435008269 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 479435008270 active site 479435008271 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 479435008272 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 479435008273 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435008274 catalytic core [active] 479435008275 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 479435008276 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 479435008277 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 479435008278 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 479435008279 Survival protein SurE; Region: SurE; cl00448 479435008280 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 479435008281 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 479435008282 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 479435008283 metal ion-dependent adhesion site (MIDAS); other site 479435008284 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 479435008285 cob(I)alamin adenolsyltransferase/cobinamide ATP-dependent adenolsyltransferase; Validated; Region: PRK05986 479435008286 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 479435008287 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435008288 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 479435008289 catalytic triad [active] 479435008290 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 479435008291 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 479435008292 putative FMN binding site [chemical binding]; other site 479435008293 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 479435008294 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435008295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435008296 Walker A/P-loop; other site 479435008297 ATP binding site [chemical binding]; other site 479435008298 Q-loop/lid; other site 479435008299 ABC transporter signature motif; other site 479435008300 Walker B; other site 479435008301 D-loop; other site 479435008302 H-loop/switch region; other site 479435008303 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 479435008304 Methyltransferase domain; Region: Methyltransf_11; pfam08241 479435008305 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479435008306 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435008307 MarR family; Region: MarR; pfam01047 479435008308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435008309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435008310 active site 479435008311 phosphorylation site [posttranslational modification] 479435008312 intermolecular recognition site; other site 479435008313 dimerization interface [polypeptide binding]; other site 479435008314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435008315 DNA binding residues [nucleotide binding] 479435008316 dimerization interface [polypeptide binding]; other site 479435008317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435008318 Histidine kinase; Region: HisKA_3; pfam07730 479435008319 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 479435008320 NMT1/THI5 like; Region: NMT1; pfam09084 479435008321 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 479435008322 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 479435008323 Walker A/P-loop; other site 479435008324 ATP binding site [chemical binding]; other site 479435008325 Q-loop/lid; other site 479435008326 ABC transporter signature motif; other site 479435008327 Walker B; other site 479435008328 D-loop; other site 479435008329 H-loop/switch region; other site 479435008330 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 479435008331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435008332 dimer interface [polypeptide binding]; other site 479435008333 conserved gate region; other site 479435008334 putative PBP binding loops; other site 479435008335 ABC-ATPase subunit interface; other site 479435008336 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 479435008337 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435008338 homotrimer interaction site [polypeptide binding]; other site 479435008339 putative active site [active] 479435008340 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479435008341 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479435008342 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435008343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 479435008344 DNA-binding site [nucleotide binding]; DNA binding site 479435008345 FCD domain; Region: FCD; pfam07729 479435008346 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435008347 classical (c) SDRs; Region: SDR_c; cd05233 479435008348 NAD(P) binding site [chemical binding]; other site 479435008349 active site 479435008350 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 479435008351 Cupin domain; Region: Cupin_2; cl17218 479435008352 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435008353 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435008354 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435008355 NAD(P) binding site [chemical binding]; other site 479435008356 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435008357 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435008358 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008359 DNA-binding site [nucleotide binding]; DNA binding site 479435008360 FCD domain; Region: FCD; pfam07729 479435008361 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 479435008362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 479435008363 DNA Polymerase Y-family; Region: PolY_like; cd03468 479435008364 active site 479435008365 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 479435008366 DNA binding site [nucleotide binding] 479435008367 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435008368 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435008369 RibD C-terminal domain; Region: RibD_C; cl17279 479435008370 RibD C-terminal domain; Region: RibD_C; cl17279 479435008371 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479435008372 active site 479435008373 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435008374 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479435008375 putative NAD(P) binding site [chemical binding]; other site 479435008376 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435008377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435008378 DNA binding residues [nucleotide binding] 479435008379 YCII-related domain; Region: YCII; cl00999 479435008380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435008381 dimerization interface [polypeptide binding]; other site 479435008382 putative DNA binding site [nucleotide binding]; other site 479435008383 putative Zn2+ binding site [ion binding]; other site 479435008384 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435008385 putative hydrophobic ligand binding site [chemical binding]; other site 479435008386 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435008387 TIGR03086 family protein; Region: TIGR03086 479435008388 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 479435008389 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479435008390 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 479435008391 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 479435008392 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 479435008393 lipoyl attachment site [posttranslational modification]; other site 479435008394 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 479435008395 Double zinc ribbon; Region: DZR; pfam12773 479435008396 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479435008397 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435008398 phosphopeptide binding site; other site 479435008399 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435008400 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435008401 DNA binding residues [nucleotide binding] 479435008402 Bifunctional nuclease; Region: DNase-RNase; pfam02577 479435008403 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 479435008404 DNA binding residues [nucleotide binding] 479435008405 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435008406 putative dimer interface [polypeptide binding]; other site 479435008407 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435008408 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435008409 inhibitor site; inhibition site 479435008410 active site 479435008411 dimer interface [polypeptide binding]; other site 479435008412 catalytic residue [active] 479435008413 glycine dehydrogenase; Provisional; Region: PRK05367 479435008414 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 479435008415 tetramer interface [polypeptide binding]; other site 479435008416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435008417 catalytic residue [active] 479435008418 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 479435008419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008420 catalytic residue [active] 479435008421 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435008422 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435008423 short chain dehydrogenase; Provisional; Region: PRK08303 479435008424 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008425 NAD(P) binding site [chemical binding]; other site 479435008426 active site 479435008427 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435008428 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008429 catalytic residue [active] 479435008430 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 479435008431 IucA / IucC family; Region: IucA_IucC; pfam04183 479435008432 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 479435008433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 479435008434 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 479435008435 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 479435008436 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435008437 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 479435008438 IucA / IucC family; Region: IucA_IucC; pfam04183 479435008439 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 479435008440 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435008441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435008442 S-adenosylmethionine binding site [chemical binding]; other site 479435008443 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 479435008444 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 479435008445 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435008446 conserved cys residue [active] 479435008447 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 479435008448 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435008449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435008450 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435008451 DinB superfamily; Region: DinB_2; pfam12867 479435008452 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 479435008453 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435008454 DinB superfamily; Region: DinB_2; pfam12867 479435008455 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 479435008456 amphipathic channel; other site 479435008457 Asn-Pro-Ala signature motifs; other site 479435008458 glycerol kinase; Provisional; Region: glpK; PRK00047 479435008459 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 479435008460 N- and C-terminal domain interface [polypeptide binding]; other site 479435008461 active site 479435008462 MgATP binding site [chemical binding]; other site 479435008463 catalytic site [active] 479435008464 metal binding site [ion binding]; metal-binding site 479435008465 putative homotetramer interface [polypeptide binding]; other site 479435008466 glycerol binding site [chemical binding]; other site 479435008467 homodimer interface [polypeptide binding]; other site 479435008468 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 479435008469 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435008470 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435008471 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 479435008472 glycerol kinase; Provisional; Region: glpK; PRK00047 479435008473 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 479435008474 N- and C-terminal domain interface [polypeptide binding]; other site 479435008475 active site 479435008476 MgATP binding site [chemical binding]; other site 479435008477 catalytic site [active] 479435008478 metal binding site [ion binding]; metal-binding site 479435008479 putative homotetramer interface [polypeptide binding]; other site 479435008480 glycerol binding site [chemical binding]; other site 479435008481 homodimer interface [polypeptide binding]; other site 479435008482 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435008483 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435008484 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435008485 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435008486 FtsX-like permease family; Region: FtsX; pfam02687 479435008487 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435008488 FtsX-like permease family; Region: FtsX; pfam02687 479435008489 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435008490 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435008491 Walker A/P-loop; other site 479435008492 ATP binding site [chemical binding]; other site 479435008493 Q-loop/lid; other site 479435008494 ABC transporter signature motif; other site 479435008495 Walker B; other site 479435008496 D-loop; other site 479435008497 H-loop/switch region; other site 479435008498 conserved hypothetical protein; Region: MG423; TIGR00649 479435008499 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435008500 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 479435008501 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479435008502 VPS10 domain; Region: VPS10; smart00602 479435008503 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 479435008504 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435008505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479435008506 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435008507 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435008508 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 479435008509 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 479435008510 Walker A/P-loop; other site 479435008511 ATP binding site [chemical binding]; other site 479435008512 Q-loop/lid; other site 479435008513 ABC transporter signature motif; other site 479435008514 Walker B; other site 479435008515 D-loop; other site 479435008516 H-loop/switch region; other site 479435008517 TOBE domain; Region: TOBE_2; pfam08402 479435008518 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 479435008519 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 479435008520 putative active site [active] 479435008521 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 479435008522 active site 479435008523 putative substrate binding region [chemical binding]; other site 479435008524 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479435008525 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 479435008526 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435008527 proteasome ATPase; Region: pup_AAA; TIGR03689 479435008528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435008529 Walker A motif; other site 479435008530 ATP binding site [chemical binding]; other site 479435008531 Walker B motif; other site 479435008532 arginine finger; other site 479435008533 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 479435008534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008535 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435008536 active site 479435008537 ATP binding site [chemical binding]; other site 479435008538 Phosphotransferase enzyme family; Region: APH; pfam01636 479435008539 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435008540 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 479435008541 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435008542 nudix motif; other site 479435008543 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008544 NAD(P) binding site [chemical binding]; other site 479435008545 active site 479435008546 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 479435008547 Pup-like protein; Region: Pup; pfam05639 479435008548 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 479435008549 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 479435008550 active site 479435008551 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 479435008552 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479435008553 active site 479435008554 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 479435008555 dimer interface [polypeptide binding]; other site 479435008556 ADP-ribose binding site [chemical binding]; other site 479435008557 active site 479435008558 nudix motif; other site 479435008559 metal binding site [ion binding]; metal-binding site 479435008560 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 479435008561 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435008562 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435008563 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435008564 Walker A/P-loop; other site 479435008565 ATP binding site [chemical binding]; other site 479435008566 Q-loop/lid; other site 479435008567 ABC transporter signature motif; other site 479435008568 Walker B; other site 479435008569 D-loop; other site 479435008570 H-loop/switch region; other site 479435008571 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435008572 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479435008573 FtsX-like permease family; Region: FtsX; pfam02687 479435008574 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435008575 FtsX-like permease family; Region: FtsX; pfam02687 479435008576 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 479435008577 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 479435008578 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 479435008579 homodimer interface [polypeptide binding]; other site 479435008580 NADP binding site [chemical binding]; other site 479435008581 substrate binding site [chemical binding]; other site 479435008582 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 479435008583 homotrimer interaction site [polypeptide binding]; other site 479435008584 active site 479435008585 prephenate dehydrogenase; Validated; Region: PRK06545 479435008586 prephenate dehydrogenase; Validated; Region: PRK08507 479435008587 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435008588 cytidylate kinase; Provisional; Region: cmk; PRK00023 479435008589 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 479435008590 CMP-binding site; other site 479435008591 The sites determining sugar specificity; other site 479435008592 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435008593 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435008594 putative acyl-acceptor binding pocket; other site 479435008595 GTP-binding protein Der; Reviewed; Region: PRK03003 479435008596 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 479435008597 G1 box; other site 479435008598 GTP/Mg2+ binding site [chemical binding]; other site 479435008599 Switch I region; other site 479435008600 G2 box; other site 479435008601 Switch II region; other site 479435008602 G3 box; other site 479435008603 G4 box; other site 479435008604 G5 box; other site 479435008605 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 479435008606 G1 box; other site 479435008607 GTP/Mg2+ binding site [chemical binding]; other site 479435008608 Switch I region; other site 479435008609 G2 box; other site 479435008610 G3 box; other site 479435008611 Switch II region; other site 479435008612 G4 box; other site 479435008613 G5 box; other site 479435008614 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 479435008615 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 479435008616 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 479435008617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 479435008618 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 479435008619 Proteins of 100 residues with WXG; Region: WXG100; cl02005 479435008620 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 479435008621 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435008622 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 479435008623 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435008624 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 479435008625 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 479435008626 iron-sulfur cluster [ion binding]; other site 479435008627 [2Fe-2S] cluster binding site [ion binding]; other site 479435008628 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 479435008629 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 479435008630 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 479435008631 calcium binding site 2 [ion binding]; other site 479435008632 active site 479435008633 catalytic triad [active] 479435008634 calcium binding site 1 [ion binding]; other site 479435008635 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 479435008636 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 479435008637 GIY-YIG motif/motif A; other site 479435008638 active site 479435008639 catalytic site [active] 479435008640 putative DNA binding site [nucleotide binding]; other site 479435008641 metal binding site [ion binding]; metal-binding site 479435008642 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 479435008643 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 479435008644 shikimate kinase; Reviewed; Region: aroK; PRK00131 479435008645 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 479435008646 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 479435008647 putative substrate binding pocket [chemical binding]; other site 479435008648 dimer interface [polypeptide binding]; other site 479435008649 phosphate binding site [ion binding]; other site 479435008650 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435008651 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435008653 DNA binding residues [nucleotide binding] 479435008654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 479435008655 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 479435008656 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 479435008657 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 479435008658 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 479435008659 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 479435008660 Phosphoglycerate kinase; Region: PGK; pfam00162 479435008661 substrate binding site [chemical binding]; other site 479435008662 hinge regions; other site 479435008663 ADP binding site [chemical binding]; other site 479435008664 catalytic site [active] 479435008665 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 479435008666 triosephosphate isomerase; Provisional; Region: PRK14567 479435008667 substrate binding site [chemical binding]; other site 479435008668 dimer interface [polypeptide binding]; other site 479435008669 catalytic triad [active] 479435008670 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 479435008671 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 479435008672 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435008673 tetramer interface [polypeptide binding]; other site 479435008674 active site 479435008675 Mg2+/Mn2+ binding site [ion binding]; other site 479435008676 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase; Region: Glucosamine_iso; pfam01182 479435008677 active site 479435008678 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 479435008679 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 479435008680 putative active site [active] 479435008681 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 479435008682 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 479435008683 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 479435008684 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479435008685 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479435008686 glucose-6-phosphate isomerase; Provisional; Region: PRK03868 479435008687 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435008688 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435008689 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 479435008690 putative active site [active] 479435008691 transaldolase; Provisional; Region: PRK03903 479435008692 catalytic residue [active] 479435008693 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 479435008694 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 479435008695 TPP-binding site [chemical binding]; other site 479435008696 dimer interface [polypeptide binding]; other site 479435008697 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479435008698 PYR/PP interface [polypeptide binding]; other site 479435008699 dimer interface [polypeptide binding]; other site 479435008700 TPP binding site [chemical binding]; other site 479435008701 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435008702 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 479435008703 UbiA prenyltransferase family; Region: UbiA; pfam01040 479435008704 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 479435008705 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 479435008706 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435008707 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435008708 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435008709 Walker A/P-loop; other site 479435008710 ATP binding site [chemical binding]; other site 479435008711 Q-loop/lid; other site 479435008712 ABC transporter signature motif; other site 479435008713 Walker B; other site 479435008714 D-loop; other site 479435008715 H-loop/switch region; other site 479435008716 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435008717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435008718 putative DNA binding site [nucleotide binding]; other site 479435008719 putative Zn2+ binding site [ion binding]; other site 479435008720 Transcriptional regulator PadR-like family; Region: PadR; cl17335 479435008721 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 479435008722 FeS assembly protein SufB; Region: sufB; TIGR01980 479435008723 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 479435008724 FeS assembly protein SufD; Region: sufD; TIGR01981 479435008725 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 479435008726 [2Fe-2S] cluster binding site [ion binding]; other site 479435008727 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 479435008728 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 479435008729 Walker A/P-loop; other site 479435008730 ATP binding site [chemical binding]; other site 479435008731 Q-loop/lid; other site 479435008732 ABC transporter signature motif; other site 479435008733 Walker B; other site 479435008734 D-loop; other site 479435008735 H-loop/switch region; other site 479435008736 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435008737 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 479435008738 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435008739 catalytic residue [active] 479435008740 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 479435008741 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 479435008742 trimerization site [polypeptide binding]; other site 479435008743 active site 479435008744 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 479435008745 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 479435008746 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 479435008747 ATP binding site [chemical binding]; other site 479435008748 Walker A motif; other site 479435008749 hexamer interface [polypeptide binding]; other site 479435008750 Walker B motif; other site 479435008751 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 479435008752 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 479435008753 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479435008754 Bacterial transcriptional activator domain; Region: BTAD; smart01043 479435008755 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435008756 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435008757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435008758 Walker A/P-loop; other site 479435008759 ATP binding site [chemical binding]; other site 479435008760 Q-loop/lid; other site 479435008761 ABC transporter signature motif; other site 479435008762 Walker B; other site 479435008763 D-loop; other site 479435008764 H-loop/switch region; other site 479435008765 ABC transporter; Region: ABC_tran_2; pfam12848 479435008766 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435008767 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 479435008768 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435008769 substrate binding site [chemical binding]; other site 479435008770 oxyanion hole (OAH) forming residues; other site 479435008771 trimer interface [polypeptide binding]; other site 479435008772 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435008773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435008774 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435008775 Walker A/P-loop; other site 479435008776 ATP binding site [chemical binding]; other site 479435008777 Q-loop/lid; other site 479435008778 ABC transporter signature motif; other site 479435008779 Walker B; other site 479435008780 D-loop; other site 479435008781 H-loop/switch region; other site 479435008782 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 479435008783 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435008784 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435008785 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 479435008786 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479435008787 carboxyltransferase (CT) interaction site; other site 479435008788 biotinylation site [posttranslational modification]; other site 479435008789 Acetyl-CoA carboxylase, central region; Region: ACC_central; pfam08326 479435008790 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 479435008791 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 479435008792 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 479435008793 active site 479435008794 DNA binding site [nucleotide binding] 479435008795 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 479435008796 DNA binding site [nucleotide binding] 479435008797 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479435008798 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435008799 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435008800 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 479435008801 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435008802 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435008803 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479435008804 phosphopeptide binding site; other site 479435008805 Phosphotransferase enzyme family; Region: APH; pfam01636 479435008806 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435008807 substrate binding site [chemical binding]; other site 479435008808 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 479435008809 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435008810 putative NAD(P) binding site [chemical binding]; other site 479435008811 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435008812 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435008813 active site 479435008814 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435008815 catalytic tetrad [active] 479435008816 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 479435008817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 479435008818 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 479435008819 Phosphotransferase enzyme family; Region: APH; pfam01636 479435008820 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 479435008821 active site 479435008822 ATP binding site [chemical binding]; other site 479435008823 antibiotic binding site [chemical binding]; other site 479435008824 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 479435008825 hydroxyglutarate oxidase; Provisional; Region: PRK11728 479435008826 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 479435008827 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 479435008828 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 479435008829 putative active site [active] 479435008830 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 479435008831 active site 479435008832 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 479435008833 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 479435008834 G1 box; other site 479435008835 putative GEF interaction site [polypeptide binding]; other site 479435008836 GTP/Mg2+ binding site [chemical binding]; other site 479435008837 Switch I region; other site 479435008838 G2 box; other site 479435008839 CysD dimerization site [polypeptide binding]; other site 479435008840 G3 box; other site 479435008841 Switch II region; other site 479435008842 G4 box; other site 479435008843 G5 box; other site 479435008844 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 479435008845 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 479435008846 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479435008847 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435008848 Active Sites [active] 479435008849 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 479435008850 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435008851 Active Sites [active] 479435008852 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 479435008853 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435008854 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435008855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435008856 dimerization interface [polypeptide binding]; other site 479435008857 putative DNA binding site [nucleotide binding]; other site 479435008858 putative Zn2+ binding site [ion binding]; other site 479435008859 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435008860 serine hydroxymethyltransferase; Provisional; Region: PRK13580 479435008861 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 479435008862 dimer interface [polypeptide binding]; other site 479435008863 active site 479435008864 glycine-pyridoxal phosphate binding site [chemical binding]; other site 479435008865 folate binding site [chemical binding]; other site 479435008866 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 479435008867 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435008868 active site 479435008869 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 479435008870 GTPase RsgA; Reviewed; Region: PRK01889 479435008871 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 479435008872 GTPase/Zn-binding domain interface [polypeptide binding]; other site 479435008873 GTP/Mg2+ binding site [chemical binding]; other site 479435008874 G4 box; other site 479435008875 G5 box; other site 479435008876 G1 box; other site 479435008877 Switch I region; other site 479435008878 G2 box; other site 479435008879 G3 box; other site 479435008880 Switch II region; other site 479435008881 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435008882 classical (c) SDRs; Region: SDR_c; cd05233 479435008883 NAD(P) binding site [chemical binding]; other site 479435008884 active site 479435008885 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435008886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435008887 ATP binding site [chemical binding]; other site 479435008888 putative Mg++ binding site [ion binding]; other site 479435008889 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 479435008890 nucleotide binding region [chemical binding]; other site 479435008891 ATP-binding site [chemical binding]; other site 479435008892 Flavoprotein; Region: Flavoprotein; cl08021 479435008893 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435008894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435008895 non-specific DNA binding site [nucleotide binding]; other site 479435008896 salt bridge; other site 479435008897 sequence-specific DNA binding site [nucleotide binding]; other site 479435008898 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 479435008899 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 479435008900 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435008901 nucleotide binding site [chemical binding]; other site 479435008902 polymerase nucleotide-binding site; other site 479435008903 primase nucleotide-binding site [nucleotide binding]; other site 479435008904 DNA-binding residues [nucleotide binding]; DNA binding site 479435008905 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 479435008906 Helix-turn-helix domain; Region: HTH_17; pfam12728 479435008907 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 479435008908 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 479435008909 active site 479435008910 catalytic residues [active] 479435008911 DNA binding site [nucleotide binding] 479435008912 Int/Topo IB signature motif; other site 479435008913 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435008914 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435008915 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 479435008916 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 479435008917 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435008918 catalytic residue [active] 479435008919 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435008920 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 479435008921 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 479435008922 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435008923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435008924 NAD(P) binding site [chemical binding]; other site 479435008925 active site 479435008926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435008927 DNA-binding site [nucleotide binding]; DNA binding site 479435008928 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435008929 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479435008930 ligand binding site [chemical binding]; other site 479435008931 dimerization interface [polypeptide binding]; other site 479435008932 Histidine kinase; Region: HisKA_3; pfam07730 479435008933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435008934 ATP binding site [chemical binding]; other site 479435008935 Mg2+ binding site [ion binding]; other site 479435008936 G-X-G motif; other site 479435008937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435008938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435008939 active site 479435008940 phosphorylation site [posttranslational modification] 479435008941 intermolecular recognition site; other site 479435008942 dimerization interface [polypeptide binding]; other site 479435008943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435008944 DNA binding residues [nucleotide binding] 479435008945 dimerization interface [polypeptide binding]; other site 479435008946 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435008947 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 479435008948 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 479435008949 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435008950 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435008951 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479435008952 Walker A/P-loop; other site 479435008953 ATP binding site [chemical binding]; other site 479435008954 Q-loop/lid; other site 479435008955 ABC transporter signature motif; other site 479435008956 Walker B; other site 479435008957 D-loop; other site 479435008958 H-loop/switch region; other site 479435008959 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 479435008960 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 479435008961 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 479435008962 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 479435008963 active site 479435008964 dimer interface [polypeptide binding]; other site 479435008965 motif 1; other site 479435008966 motif 2; other site 479435008967 motif 3; other site 479435008968 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 479435008969 anticodon binding site; other site 479435008970 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 479435008971 nucleotide binding site/active site [active] 479435008972 HIT family signature motif; other site 479435008973 catalytic residue [active] 479435008974 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 479435008975 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 479435008976 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 479435008977 putative acyl-acceptor binding pocket; other site 479435008978 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435008979 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435008980 Putative zinc-finger; Region: zf-HC2; pfam13490 479435008981 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435008982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435008983 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435008984 DNA binding residues [nucleotide binding] 479435008985 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435008986 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 479435008987 HIT family signature motif; other site 479435008988 catalytic residue [active] 479435008989 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008990 binding surface 479435008991 TPR motif; other site 479435008992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435008993 Tetratricopeptide repeat; Region: TPR_16; pfam13432 479435008994 TPR motif; other site 479435008995 binding surface 479435008996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435008997 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479435008998 Walker A motif; other site 479435008999 ATP binding site [chemical binding]; other site 479435009000 Walker B motif; other site 479435009001 arginine finger; other site 479435009002 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 479435009003 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435009004 putative NAD(P) binding site [chemical binding]; other site 479435009005 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435009006 dimerization interface [polypeptide binding]; other site 479435009007 putative DNA binding site [nucleotide binding]; other site 479435009008 putative Zn2+ binding site [ion binding]; other site 479435009009 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 479435009010 elongation factor G; Reviewed; Region: PRK12740 479435009011 G1 box; other site 479435009012 putative GEF interaction site [polypeptide binding]; other site 479435009013 GTP/Mg2+ binding site [chemical binding]; other site 479435009014 Switch I region; other site 479435009015 G2 box; other site 479435009016 G3 box; other site 479435009017 Switch II region; other site 479435009018 G4 box; other site 479435009019 G5 box; other site 479435009020 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 479435009021 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 479435009022 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 479435009023 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435009024 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435009025 DNA binding residues [nucleotide binding] 479435009026 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435009027 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435009028 active site 479435009029 Int/Topo IB signature motif; other site 479435009030 DNA binding site [nucleotide binding] 479435009031 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 479435009032 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 479435009033 Ferritin-like domain; Region: Ferritin; pfam00210 479435009034 ferroxidase diiron center [ion binding]; other site 479435009035 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 479435009036 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 479435009037 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435009038 putative ligand binding site [chemical binding]; other site 479435009039 putative NAD binding site [chemical binding]; other site 479435009040 catalytic site [active] 479435009041 PAC2 family; Region: PAC2; pfam09754 479435009042 Predicted membrane protein [Function unknown]; Region: COG2259 479435009043 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 479435009044 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 479435009045 active site 479435009046 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 479435009047 catalytic triad [active] 479435009048 dimer interface [polypeptide binding]; other site 479435009049 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 479435009050 active site 479435009051 dimer interface [polypeptide binding]; other site 479435009052 motif 1; other site 479435009053 motif 2; other site 479435009054 motif 3; other site 479435009055 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 479435009056 anticodon binding site; other site 479435009057 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479435009058 active site 2 [active] 479435009059 active site 1 [active] 479435009060 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 479435009061 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009062 NAD(P) binding site [chemical binding]; other site 479435009063 active site 479435009064 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 479435009065 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435009066 dimer interface [polypeptide binding]; other site 479435009067 active site 479435009068 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009069 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009070 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435009071 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435009072 active site 479435009073 hypothetical protein; Provisional; Region: PRK01346 479435009074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 479435009075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435009076 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435009077 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435009078 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435009079 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435009080 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435009081 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435009082 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435009083 Helix-turn-helix domain; Region: HTH_31; pfam13560 479435009084 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435009085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009086 S-adenosylmethionine binding site [chemical binding]; other site 479435009087 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 479435009088 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 479435009089 active site 479435009090 DNA binding site [nucleotide binding] 479435009091 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 479435009092 DNA binding site [nucleotide binding] 479435009093 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 479435009094 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 479435009095 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 479435009096 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435009097 catalytic residue [active] 479435009098 CAAX protease self-immunity; Region: Abi; pfam02517 479435009099 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 479435009100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435009101 motif II; other site 479435009102 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 479435009103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009104 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435009105 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 479435009106 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435009107 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435009108 putative sugar binding sites [chemical binding]; other site 479435009109 Q-X-W motif; other site 479435009110 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 479435009111 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435009112 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 479435009113 putative active site [active] 479435009114 putative catalytic site [active] 479435009115 putative DNA binding site [nucleotide binding]; other site 479435009116 putative phosphate binding site [ion binding]; other site 479435009117 metal binding site A [ion binding]; metal-binding site 479435009118 putative AP binding site [nucleotide binding]; other site 479435009119 putative metal binding site B [ion binding]; other site 479435009120 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009122 short chain dehydrogenase; Provisional; Region: PRK07825 479435009123 classical (c) SDRs; Region: SDR_c; cd05233 479435009124 NAD(P) binding site [chemical binding]; other site 479435009125 active site 479435009126 Uncharacterized conserved protein [Function unknown]; Region: COG3268 479435009127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009128 NAD(P) binding site [chemical binding]; other site 479435009129 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435009130 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435009131 hypothetical protein; Provisional; Region: PRK11770 479435009132 Domain of unknown function (DUF307); Region: DUF307; pfam03733 479435009133 Domain of unknown function (DUF307); Region: DUF307; pfam03733 479435009134 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 479435009135 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479435009136 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 479435009137 Amidinotransferase; Region: Amidinotransf; cl12043 479435009138 DNA polymerase IV; Provisional; Region: PRK03348 479435009139 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479435009140 active site 479435009141 DNA binding site [nucleotide binding] 479435009142 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435009143 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479435009144 Ligand Binding Site [chemical binding]; other site 479435009145 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435009146 minor groove reading motif; other site 479435009147 helix-hairpin-helix signature motif; other site 479435009148 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 479435009149 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 479435009150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009151 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435009152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435009153 DNA binding residues [nucleotide binding] 479435009154 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 479435009155 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435009156 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435009157 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435009158 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435009159 Predicted ATPase [General function prediction only]; Region: COG3903 479435009160 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435009161 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 479435009162 TPR motif; other site 479435009163 binding surface 479435009164 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435009165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009166 S-adenosylmethionine binding site [chemical binding]; other site 479435009167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435009168 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435009169 dimerization interface [polypeptide binding]; other site 479435009170 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435009171 dimer interface [polypeptide binding]; other site 479435009172 phosphorylation site [posttranslational modification] 479435009173 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435009174 ATP binding site [chemical binding]; other site 479435009175 Mg2+ binding site [ion binding]; other site 479435009176 G-X-G motif; other site 479435009177 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435009178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435009179 active site 479435009180 phosphorylation site [posttranslational modification] 479435009181 intermolecular recognition site; other site 479435009182 dimerization interface [polypeptide binding]; other site 479435009183 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435009184 DNA binding site [nucleotide binding] 479435009185 Protein of unknown function (DUF456); Region: DUF456; pfam04306 479435009186 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 479435009187 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435009188 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435009189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435009190 DNA-binding site [nucleotide binding]; DNA binding site 479435009191 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435009192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435009193 homodimer interface [polypeptide binding]; other site 479435009194 catalytic residue [active] 479435009195 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 479435009196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435009197 ATP binding site [chemical binding]; other site 479435009198 Mg2+ binding site [ion binding]; other site 479435009199 G-X-G motif; other site 479435009200 DNA gyrase B; Region: DNA_gyraseB; pfam00204 479435009201 ATP binding site [chemical binding]; other site 479435009202 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 479435009203 active site 479435009204 metal binding site [ion binding]; metal-binding site 479435009205 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 479435009206 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479435009207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435009208 motif II; other site 479435009209 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 479435009210 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 479435009211 active site clefts [active] 479435009212 zinc binding site [ion binding]; other site 479435009213 dimer interface [polypeptide binding]; other site 479435009214 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 479435009215 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 479435009216 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 479435009217 active site clefts [active] 479435009218 zinc binding site [ion binding]; other site 479435009219 dimer interface [polypeptide binding]; other site 479435009220 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435009221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009222 putative substrate translocation pore; other site 479435009223 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 479435009224 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 479435009225 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 479435009226 CAP-like domain; other site 479435009227 active site 479435009228 primary dimer interface [polypeptide binding]; other site 479435009229 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435009230 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 479435009231 FtsX-like permease family; Region: FtsX; pfam02687 479435009232 FtsX-like permease family; Region: FtsX; pfam02687 479435009233 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435009234 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435009235 Walker A/P-loop; other site 479435009236 ATP binding site [chemical binding]; other site 479435009237 Q-loop/lid; other site 479435009238 ABC transporter signature motif; other site 479435009239 Walker B; other site 479435009240 D-loop; other site 479435009241 H-loop/switch region; other site 479435009242 Putative sensor; Region: Sensor; pfam13796 479435009243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435009244 Histidine kinase; Region: HisKA_3; pfam07730 479435009245 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435009246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435009247 active site 479435009248 phosphorylation site [posttranslational modification] 479435009249 intermolecular recognition site; other site 479435009250 dimerization interface [polypeptide binding]; other site 479435009251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435009252 DNA binding residues [nucleotide binding] 479435009253 dimerization interface [polypeptide binding]; other site 479435009254 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 479435009255 PPOX class probable F420-dependent enzyme, Rv3369 family; Region: Rv3369; TIGR03667 479435009256 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 479435009257 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 479435009258 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 479435009259 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435009260 acyl-activating enzyme (AAE) consensus motif; other site 479435009261 AMP binding site [chemical binding]; other site 479435009262 active site 479435009263 CoA binding site [chemical binding]; other site 479435009264 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 479435009265 transmembrane helices; other site 479435009266 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 479435009267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435009268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435009269 Coenzyme A binding pocket [chemical binding]; other site 479435009270 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 479435009271 CoA binding domain; Region: CoA_binding_2; pfam13380 479435009272 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 479435009273 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 479435009274 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435009275 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 479435009276 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435009277 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435009278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 479435009279 putative DNA binding site [nucleotide binding]; other site 479435009280 putative Zn2+ binding site [ion binding]; other site 479435009281 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 479435009282 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 479435009283 putative active site pocket [active] 479435009284 cleavage site 479435009285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435009286 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435009287 Walker A/P-loop; other site 479435009288 ATP binding site [chemical binding]; other site 479435009289 Q-loop/lid; other site 479435009290 ABC transporter signature motif; other site 479435009291 Walker B; other site 479435009292 D-loop; other site 479435009293 H-loop/switch region; other site 479435009294 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 479435009295 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435009296 active site 479435009297 catalytic residues [active] 479435009298 thymidine kinase; Provisional; Region: PRK04296 479435009299 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 479435009300 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 479435009301 active site residue [active] 479435009302 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 479435009303 active site residue [active] 479435009304 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 479435009305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435009306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435009307 Coenzyme A binding pocket [chemical binding]; other site 479435009308 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435009309 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435009310 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435009311 putative dimerization interface [polypeptide binding]; other site 479435009312 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435009313 Class I aldolases; Region: Aldolase_Class_I; cl17187 479435009314 catalytic residue [active] 479435009315 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435009316 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479435009317 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435009318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435009319 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435009320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009321 dimer interface [polypeptide binding]; other site 479435009322 conserved gate region; other site 479435009323 putative PBP binding loops; other site 479435009324 ABC-ATPase subunit interface; other site 479435009325 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435009326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009327 dimer interface [polypeptide binding]; other site 479435009328 conserved gate region; other site 479435009329 putative PBP binding loops; other site 479435009330 ABC-ATPase subunit interface; other site 479435009331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435009332 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009333 NAD(P) binding site [chemical binding]; other site 479435009334 active site 479435009335 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 479435009336 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 479435009337 metal binding site [ion binding]; metal-binding site 479435009338 substrate binding pocket [chemical binding]; other site 479435009339 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435009340 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435009341 putative DNA binding site [nucleotide binding]; other site 479435009342 putative Zn2+ binding site [ion binding]; other site 479435009343 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435009344 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435009345 nucleotide binding site [chemical binding]; other site 479435009346 short chain dehydrogenase; Provisional; Region: PRK06500 479435009347 classical (c) SDRs; Region: SDR_c; cd05233 479435009348 NAD(P) binding site [chemical binding]; other site 479435009349 active site 479435009350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435009351 salt bridge; other site 479435009352 non-specific DNA binding site [nucleotide binding]; other site 479435009353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435009354 sequence-specific DNA binding site [nucleotide binding]; other site 479435009355 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435009356 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435009357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435009358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435009359 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435009360 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435009361 sugar binding site [chemical binding]; other site 479435009362 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435009363 Erythromycin esterase; Region: Erythro_esteras; cl17110 479435009364 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009365 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435009366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009367 NAD(P) binding site [chemical binding]; other site 479435009368 active site 479435009369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009370 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435009371 NAD(P) binding site [chemical binding]; other site 479435009372 active site 479435009373 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 479435009374 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 479435009375 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 479435009376 Zn binding site [ion binding]; other site 479435009377 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435009378 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435009379 active site 479435009380 catalytic tetrad [active] 479435009381 hypothetical protein; Validated; Region: PRK02101 479435009382 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 479435009383 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 479435009384 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435009385 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 479435009386 dimerization interface [polypeptide binding]; other site 479435009387 DNA binding residues [nucleotide binding] 479435009388 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479435009389 EamA-like transporter family; Region: EamA; pfam00892 479435009390 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435009391 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435009392 DNA-binding site [nucleotide binding]; DNA binding site 479435009393 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435009394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435009395 homodimer interface [polypeptide binding]; other site 479435009396 catalytic residue [active] 479435009397 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435009398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009399 putative substrate translocation pore; other site 479435009400 Rhomboid family; Region: Rhomboid; pfam01694 479435009401 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435009402 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435009403 Walker A/P-loop; other site 479435009404 ATP binding site [chemical binding]; other site 479435009405 Q-loop/lid; other site 479435009406 ABC transporter signature motif; other site 479435009407 Walker B; other site 479435009408 D-loop; other site 479435009409 H-loop/switch region; other site 479435009410 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435009411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435009412 active site 479435009413 phosphorylation site [posttranslational modification] 479435009414 intermolecular recognition site; other site 479435009415 dimerization interface [polypeptide binding]; other site 479435009416 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435009417 DNA binding site [nucleotide binding] 479435009418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435009419 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435009420 dimerization interface [polypeptide binding]; other site 479435009421 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435009422 dimer interface [polypeptide binding]; other site 479435009423 phosphorylation site [posttranslational modification] 479435009424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435009425 ATP binding site [chemical binding]; other site 479435009426 Mg2+ binding site [ion binding]; other site 479435009427 G-X-G motif; other site 479435009428 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 479435009429 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 479435009430 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 479435009431 threonine dehydratase; Provisional; Region: PRK08246 479435009432 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435009433 catalytic residue [active] 479435009434 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435009435 non-specific DNA binding site [nucleotide binding]; other site 479435009436 salt bridge; other site 479435009437 sequence-specific DNA binding site [nucleotide binding]; other site 479435009438 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 479435009439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009440 NAD(P) binding site [chemical binding]; other site 479435009441 active site 479435009442 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435009443 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 479435009444 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479435009445 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 479435009446 putative DNA binding site [nucleotide binding]; other site 479435009447 putative Zn2+ binding site [ion binding]; other site 479435009448 AsnC family; Region: AsnC_trans_reg; pfam01037 479435009449 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435009450 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479435009451 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 479435009452 nucleoside/Zn binding site; other site 479435009453 dimer interface [polypeptide binding]; other site 479435009454 catalytic motif [active] 479435009455 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435009456 HTH domain; Region: HTH_11; pfam08279 479435009457 WYL domain; Region: WYL; pfam13280 479435009458 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435009459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009460 S-adenosylmethionine binding site [chemical binding]; other site 479435009461 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479435009462 active site 479435009463 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435009464 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435009465 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435009466 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435009467 active site 479435009468 catalytic tetrad [active] 479435009469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009470 S-adenosylmethionine binding site [chemical binding]; other site 479435009471 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 479435009472 aromatic arch; other site 479435009473 DCoH dimer interaction site [polypeptide binding]; other site 479435009474 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 479435009475 DCoH tetramer interaction site [polypeptide binding]; other site 479435009476 substrate binding site [chemical binding]; other site 479435009477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435009478 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009479 S-adenosylmethionine binding site [chemical binding]; other site 479435009480 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435009481 putative dimer interface [polypeptide binding]; other site 479435009482 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435009483 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435009484 active site 479435009485 DNA binding site [nucleotide binding] 479435009486 Int/Topo IB signature motif; other site 479435009487 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 479435009488 nucleotide binding site [chemical binding]; other site 479435009489 substrate binding site [chemical binding]; other site 479435009490 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 479435009491 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 479435009492 G1 box; other site 479435009493 putative GEF interaction site [polypeptide binding]; other site 479435009494 GTP/Mg2+ binding site [chemical binding]; other site 479435009495 Switch I region; other site 479435009496 G2 box; other site 479435009497 G3 box; other site 479435009498 Switch II region; other site 479435009499 G4 box; other site 479435009500 G5 box; other site 479435009501 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 479435009502 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 479435009503 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 479435009504 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435009505 active site 479435009506 metal binding site [ion binding]; metal-binding site 479435009507 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435009508 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435009509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435009510 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 479435009511 YCII-related domain; Region: YCII; cl00999 479435009512 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435009513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009514 dimer interface [polypeptide binding]; other site 479435009515 conserved gate region; other site 479435009516 putative PBP binding loops; other site 479435009517 ABC-ATPase subunit interface; other site 479435009518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009519 dimer interface [polypeptide binding]; other site 479435009520 conserved gate region; other site 479435009521 putative PBP binding loops; other site 479435009522 ABC-ATPase subunit interface; other site 479435009523 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435009524 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435009525 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435009526 DNA binding site [nucleotide binding] 479435009527 domain linker motif; other site 479435009528 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435009529 dimerization interface [polypeptide binding]; other site 479435009530 ligand binding site [chemical binding]; other site 479435009531 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435009532 classical (c) SDRs; Region: SDR_c; cd05233 479435009533 NAD(P) binding site [chemical binding]; other site 479435009534 active site 479435009535 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435009536 MarR family; Region: MarR_2; pfam12802 479435009537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435009538 Walker A/P-loop; other site 479435009539 ATP binding site [chemical binding]; other site 479435009540 Q-loop/lid; other site 479435009541 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 479435009542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435009543 ABC transporter signature motif; other site 479435009544 Walker B; other site 479435009545 D-loop; other site 479435009546 H-loop/switch region; other site 479435009547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435009548 Walker A/P-loop; other site 479435009549 ATP binding site [chemical binding]; other site 479435009550 Q-loop/lid; other site 479435009551 ABC transporter signature motif; other site 479435009552 Walker B; other site 479435009553 D-loop; other site 479435009554 H-loop/switch region; other site 479435009555 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435009556 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435009557 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435009558 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009559 NAD(P) binding site [chemical binding]; other site 479435009560 active site 479435009561 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 479435009562 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435009563 DNA-binding site [nucleotide binding]; DNA binding site 479435009564 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435009565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435009566 homodimer interface [polypeptide binding]; other site 479435009567 catalytic residue [active] 479435009568 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435009569 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435009570 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435009571 catalytic residue [active] 479435009572 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435009573 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435009574 putative hydrophobic ligand binding site [chemical binding]; other site 479435009575 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435009576 hydrophobic ligand binding site; other site 479435009577 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435009578 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 479435009579 active site 479435009580 Zn binding site [ion binding]; other site 479435009581 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 479435009582 active site 479435009583 catalytic triad [active] 479435009584 oxyanion hole [active] 479435009585 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479435009586 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 479435009587 Walker A/P-loop; other site 479435009588 ATP binding site [chemical binding]; other site 479435009589 Q-loop/lid; other site 479435009590 ABC transporter signature motif; other site 479435009591 Walker B; other site 479435009592 D-loop; other site 479435009593 H-loop/switch region; other site 479435009594 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 479435009595 cobalt transport protein CbiM; Validated; Region: PRK06265 479435009596 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 479435009597 PDGLE domain; Region: PDGLE; pfam13190 479435009598 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 479435009599 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435009600 active site 479435009601 metal binding site [ion binding]; metal-binding site 479435009602 hexamer interface [polypeptide binding]; other site 479435009603 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 479435009604 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 479435009605 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435009606 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435009607 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435009608 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435009609 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479435009610 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 479435009611 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009612 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009613 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 479435009614 hypothetical protein; Provisional; Region: PRK07236 479435009615 hypothetical protein; Provisional; Region: PRK07588 479435009616 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009617 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435009618 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 479435009619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435009620 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435009621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435009622 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 479435009623 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 479435009624 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435009625 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435009626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009627 dimer interface [polypeptide binding]; other site 479435009628 putative PBP binding loops; other site 479435009629 ABC-ATPase subunit interface; other site 479435009630 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435009631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009632 dimer interface [polypeptide binding]; other site 479435009633 conserved gate region; other site 479435009634 putative PBP binding loops; other site 479435009635 ABC-ATPase subunit interface; other site 479435009636 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009637 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 479435009638 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 479435009639 Amidohydrolase; Region: Amidohydro_2; pfam04909 479435009640 active site 479435009641 enoyl-CoA hydratase; Provisional; Region: PRK06144 479435009642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435009643 substrate binding site [chemical binding]; other site 479435009644 oxyanion hole (OAH) forming residues; other site 479435009645 trimer interface [polypeptide binding]; other site 479435009646 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 479435009647 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479435009648 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479435009649 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435009650 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435009651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435009652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009653 dimer interface [polypeptide binding]; other site 479435009654 conserved gate region; other site 479435009655 putative PBP binding loops; other site 479435009656 ABC-ATPase subunit interface; other site 479435009657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435009658 dimer interface [polypeptide binding]; other site 479435009659 putative PBP binding loops; other site 479435009660 ABC-ATPase subunit interface; other site 479435009661 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435009662 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435009663 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435009664 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435009665 DNA-binding site [nucleotide binding]; DNA binding site 479435009666 FCD domain; Region: FCD; pfam07729 479435009667 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435009668 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435009669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435009670 catalytic residue [active] 479435009671 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 479435009672 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435009673 putative active site [active] 479435009674 catalytic site [active] 479435009675 putative metal binding site [ion binding]; other site 479435009676 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 479435009677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009678 putative substrate translocation pore; other site 479435009679 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 479435009680 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 479435009681 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 479435009682 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 479435009683 putative active site [active] 479435009684 catalytic triad [active] 479435009685 putative dimer interface [polypeptide binding]; other site 479435009686 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479435009687 active site 2 [active] 479435009688 active site 1 [active] 479435009689 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 479435009690 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 479435009691 B12 binding site [chemical binding]; other site 479435009692 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 479435009693 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 479435009694 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 479435009695 active site 479435009696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 479435009697 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435009698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435009699 S-adenosylmethionine binding site [chemical binding]; other site 479435009700 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479435009701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435009702 putative DNA binding site [nucleotide binding]; other site 479435009703 putative Zn2+ binding site [ion binding]; other site 479435009704 AsnC family; Region: AsnC_trans_reg; pfam01037 479435009705 5'-3' exonuclease; Region: 53EXOc; smart00475 479435009706 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 479435009707 active site 479435009708 metal binding site 1 [ion binding]; metal-binding site 479435009709 putative 5' ssDNA interaction site; other site 479435009710 metal binding site 3; metal-binding site 479435009711 metal binding site 2 [ion binding]; metal-binding site 479435009712 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 479435009713 putative DNA binding site [nucleotide binding]; other site 479435009714 putative metal binding site [ion binding]; other site 479435009715 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 479435009716 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 479435009717 metal binding site [ion binding]; metal-binding site 479435009718 dimer interface [polypeptide binding]; other site 479435009719 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435009720 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435009721 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435009722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435009723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435009724 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 479435009725 Walker A/P-loop; other site 479435009726 ATP binding site [chemical binding]; other site 479435009727 Q-loop/lid; other site 479435009728 ABC transporter signature motif; other site 479435009729 Walker B; other site 479435009730 D-loop; other site 479435009731 H-loop/switch region; other site 479435009732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435009733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435009734 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435009735 Walker A/P-loop; other site 479435009736 ATP binding site [chemical binding]; other site 479435009737 Q-loop/lid; other site 479435009738 ABC transporter signature motif; other site 479435009739 Walker B; other site 479435009740 D-loop; other site 479435009741 H-loop/switch region; other site 479435009742 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009743 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009744 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435009745 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435009746 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435009747 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435009748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435009749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435009750 Walker A/P-loop; other site 479435009751 ATP binding site [chemical binding]; other site 479435009752 Q-loop/lid; other site 479435009753 ABC transporter signature motif; other site 479435009754 Walker B; other site 479435009755 D-loop; other site 479435009756 H-loop/switch region; other site 479435009757 SNF2 Helicase protein; Region: DUF3670; pfam12419 479435009758 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 479435009759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435009760 ATP binding site [chemical binding]; other site 479435009761 putative Mg++ binding site [ion binding]; other site 479435009762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435009763 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 479435009764 nucleotide binding region [chemical binding]; other site 479435009765 ATP-binding site [chemical binding]; other site 479435009766 Uncharacterized conserved protein [Function unknown]; Region: COG4279 479435009767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435009768 Coenzyme A binding pocket [chemical binding]; other site 479435009769 Putative Lactate dehydrogenase and (R)-2-Hydroxyglutarate Dehydrogenase-like proteins, NAD-binding and catalytic domains; Region: HGDH_LDH_like; cd12185 479435009770 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435009771 putative ligand binding site [chemical binding]; other site 479435009772 putative NAD binding site [chemical binding]; other site 479435009773 catalytic site [active] 479435009774 D-alanine--D-lactate ligase; Provisional; Region: vanB; PRK14568 479435009775 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435009776 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 479435009777 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 479435009778 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 479435009779 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 479435009780 active site 479435009781 homodimer interface [polypeptide binding]; other site 479435009782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435009783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435009784 Coenzyme A binding pocket [chemical binding]; other site 479435009785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435009786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435009787 dimerization interface [polypeptide binding]; other site 479435009788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435009789 dimer interface [polypeptide binding]; other site 479435009790 phosphorylation site [posttranslational modification] 479435009791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435009792 ATP binding site [chemical binding]; other site 479435009793 Mg2+ binding site [ion binding]; other site 479435009794 G-X-G motif; other site 479435009795 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435009796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435009797 active site 479435009798 phosphorylation site [posttranslational modification] 479435009799 intermolecular recognition site; other site 479435009800 dimerization interface [polypeptide binding]; other site 479435009801 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435009802 DNA binding site [nucleotide binding] 479435009803 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 479435009804 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479435009805 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479435009806 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435009807 Coenzyme A binding pocket [chemical binding]; other site 479435009808 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 479435009809 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 479435009810 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435009811 dimerization interface [polypeptide binding]; other site 479435009812 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 479435009813 cyclase homology domain; Region: CHD; cd07302 479435009814 nucleotidyl binding site; other site 479435009815 metal binding site [ion binding]; metal-binding site 479435009816 dimer interface [polypeptide binding]; other site 479435009817 short chain dehydrogenase; Provisional; Region: PRK06123 479435009818 classical (c) SDRs; Region: SDR_c; cd05233 479435009819 NAD(P) binding site [chemical binding]; other site 479435009820 active site 479435009821 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435009822 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435009823 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435009824 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 479435009825 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435009826 putative NAD(P) binding site [chemical binding]; other site 479435009827 putative active site [active] 479435009828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435009829 dimerization interface [polypeptide binding]; other site 479435009830 putative DNA binding site [nucleotide binding]; other site 479435009831 putative Zn2+ binding site [ion binding]; other site 479435009832 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 479435009833 putative hydrophobic ligand binding site [chemical binding]; other site 479435009834 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435009835 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435009836 ATP binding site [chemical binding]; other site 479435009837 putative Mg++ binding site [ion binding]; other site 479435009838 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435009839 nucleotide binding region [chemical binding]; other site 479435009840 ATP-binding site [chemical binding]; other site 479435009841 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435009842 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435009843 DNA binding residues [nucleotide binding] 479435009844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435009845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435009846 putative substrate translocation pore; other site 479435009847 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435009848 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435009849 conserved cys residue [active] 479435009850 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 479435009851 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 479435009852 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 479435009853 active site 479435009854 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435009855 short chain dehydrogenase; Provisional; Region: PRK05866 479435009856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435009857 NAD(P) binding site [chemical binding]; other site 479435009858 active site 479435009859 acyl-CoA synthetase; Validated; Region: PRK07788 479435009860 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435009861 acyl-activating enzyme (AAE) consensus motif; other site 479435009862 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 479435009863 putative AMP binding site [chemical binding]; other site 479435009864 putative active site [active] 479435009865 acyl-activating enzyme (AAE) consensus motif; other site 479435009866 putative CoA binding site [chemical binding]; other site 479435009867 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 479435009868 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 479435009869 active site 479435009870 citrylCoA binding site [chemical binding]; other site 479435009871 oxalacetate binding site [chemical binding]; other site 479435009872 coenzyme A binding site [chemical binding]; other site 479435009873 catalytic triad [active] 479435009874 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479435009875 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479435009876 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479435009877 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435009878 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435009879 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 479435009880 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 479435009881 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 479435009882 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 479435009883 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 479435009884 Ligand Binding Site [chemical binding]; other site 479435009885 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 479435009886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435009887 ATP binding site [chemical binding]; other site 479435009888 putative Mg++ binding site [ion binding]; other site 479435009889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435009890 nucleotide binding region [chemical binding]; other site 479435009891 ATP-binding site [chemical binding]; other site 479435009892 Helicase associated domain (HA2); Region: HA2; pfam04408 479435009893 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 479435009894 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 479435009895 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435009896 sugar binding site [chemical binding]; other site 479435009897 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 479435009898 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479435009899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435009900 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435009901 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435009902 active site 479435009903 metal binding site [ion binding]; metal-binding site 479435009904 Fructosamine kinase; Region: Fructosamin_kin; cl17579 479435009905 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 479435009906 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 479435009907 active site 479435009908 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479435009909 DNA-binding site [nucleotide binding]; DNA binding site 479435009910 RNA-binding motif; other site 479435009911 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435009912 BCCT family transporter; Region: BCCT; pfam02028 479435009913 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 479435009914 Strictosidine synthase; Region: Str_synth; pfam03088 479435009915 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 479435009916 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435009917 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435009918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435009919 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 479435009920 Walker A motif; other site 479435009921 ATP binding site [chemical binding]; other site 479435009922 Walker B motif; other site 479435009923 arginine finger; other site 479435009924 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 479435009925 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435009926 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 479435009927 active site 479435009928 catalytic residues [active] 479435009929 metal binding site [ion binding]; metal-binding site 479435009930 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435009931 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435009932 DNA binding site [nucleotide binding] 479435009933 domain linker motif; other site 479435009934 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435009935 dimerization interface [polypeptide binding]; other site 479435009936 ligand binding site [chemical binding]; other site 479435009937 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435009938 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435009939 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435009940 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479435009941 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 479435009942 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 479435009943 active site 479435009944 SAM binding site [chemical binding]; other site 479435009945 homodimer interface [polypeptide binding]; other site 479435009946 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 479435009947 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 479435009948 putative dimer interface [polypeptide binding]; other site 479435009949 active site pocket [active] 479435009950 putative cataytic base [active] 479435009951 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 479435009952 substrate binding site [chemical binding]; other site 479435009953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435009954 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 479435009955 substrate binding site [chemical binding]; other site 479435009956 oxyanion hole (OAH) forming residues; other site 479435009957 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435009958 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435009959 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 479435009960 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435009961 dimer interface [polypeptide binding]; other site 479435009962 active site 479435009963 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435009964 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435009965 DNA binding residues [nucleotide binding] 479435009966 dimer interface [polypeptide binding]; other site 479435009967 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435009968 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435009969 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435009970 TM-ABC transporter signature motif; other site 479435009971 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435009972 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435009973 Walker A/P-loop; other site 479435009974 ATP binding site [chemical binding]; other site 479435009975 Q-loop/lid; other site 479435009976 ABC transporter signature motif; other site 479435009977 Walker B; other site 479435009978 D-loop; other site 479435009979 H-loop/switch region; other site 479435009980 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 479435009981 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479435009982 putative ligand binding site [chemical binding]; other site 479435009983 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 479435009984 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 479435009985 FAD binding pocket [chemical binding]; other site 479435009986 FAD binding motif [chemical binding]; other site 479435009987 phosphate binding motif [ion binding]; other site 479435009988 beta-alpha-beta structure motif; other site 479435009989 NAD binding pocket [chemical binding]; other site 479435009990 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 479435009991 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 479435009992 Moco binding site; other site 479435009993 metal coordination site [ion binding]; other site 479435009994 AAA ATPase domain; Region: AAA_16; pfam13191 479435009995 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435009996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435009997 active site 479435009998 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479435009999 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479435010000 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435010001 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cl00379 479435010002 L5 interface [polypeptide binding]; other site 479435010003 cobyric acid synthase; Provisional; Region: PRK00784 479435010004 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435010005 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 479435010006 catalytic triad [active] 479435010007 benzoate transport; Region: 2A0115; TIGR00895 479435010008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010009 putative substrate translocation pore; other site 479435010010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010011 Predicted acetyltransferase [General function prediction only]; Region: COG2388 479435010012 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 479435010013 putative deacylase active site [active] 479435010014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435010015 non-specific DNA binding site [nucleotide binding]; other site 479435010016 salt bridge; other site 479435010017 sequence-specific DNA binding site [nucleotide binding]; other site 479435010018 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 479435010019 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435010020 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 479435010021 NAD(P) binding site [chemical binding]; other site 479435010022 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010023 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010024 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435010025 hypothetical protein; Provisional; Region: PRK10621 479435010026 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 479435010027 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479435010028 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 479435010029 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 479435010030 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479435010031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435010032 Walker A/P-loop; other site 479435010033 ATP binding site [chemical binding]; other site 479435010034 Q-loop/lid; other site 479435010035 ABC transporter signature motif; other site 479435010036 Walker B; other site 479435010037 D-loop; other site 479435010038 H-loop/switch region; other site 479435010039 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435010040 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 479435010041 phosphoserine phosphatase SerB; Region: serB; TIGR00338 479435010042 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435010043 motif II; other site 479435010044 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435010045 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435010046 Coenzyme A binding pocket [chemical binding]; other site 479435010047 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 479435010048 active site 479435010049 catalytic residues [active] 479435010050 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 479435010051 metal binding site [ion binding]; metal-binding site 479435010052 ligand binding site [chemical binding]; other site 479435010053 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 479435010054 proposed catalytic triad [active] 479435010055 active site nucleophile [active] 479435010056 cyanophycin synthetase; Provisional; Region: PRK14016 479435010057 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435010058 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435010059 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435010060 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435010061 Protein of unknown function (DUF461); Region: DUF461; pfam04314 479435010062 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 479435010063 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479435010064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 479435010065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 479435010066 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 479435010067 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 479435010068 NAD binding site [chemical binding]; other site 479435010069 homotetramer interface [polypeptide binding]; other site 479435010070 homodimer interface [polypeptide binding]; other site 479435010071 substrate binding site [chemical binding]; other site 479435010072 active site 479435010073 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 479435010074 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435010075 NAD(P) binding site [chemical binding]; other site 479435010076 homotetramer interface [polypeptide binding]; other site 479435010077 homodimer interface [polypeptide binding]; other site 479435010078 active site 479435010079 Dodecin; Region: Dodecin; pfam07311 479435010080 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 479435010081 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 479435010082 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435010083 FeS/SAM binding site; other site 479435010084 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 479435010085 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 479435010086 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479435010087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010088 NAD(P) binding site [chemical binding]; other site 479435010089 active site 479435010090 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 479435010091 Predicted metalloprotease [General function prediction only]; Region: COG2321 479435010092 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 479435010093 nucleotide binding site [chemical binding]; other site 479435010094 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 479435010095 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435010096 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 479435010097 active site 479435010098 Zn binding site [ion binding]; other site 479435010099 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 479435010100 generic binding surface I; other site 479435010101 generic binding surface II; other site 479435010102 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435010103 putative catalytic site [active] 479435010104 putative metal binding site [ion binding]; other site 479435010105 putative phosphate binding site [ion binding]; other site 479435010106 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 479435010107 SelR domain; Region: SelR; pfam01641 479435010108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435010109 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435010110 active site 479435010111 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 479435010112 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 479435010113 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 479435010114 substrate binding site [chemical binding]; other site 479435010115 active site 479435010116 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 479435010117 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 479435010118 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 479435010119 catalytic site [active] 479435010120 putative active site [active] 479435010121 putative substrate binding site [chemical binding]; other site 479435010122 HRDC domain; Region: HRDC; pfam00570 479435010123 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 479435010124 catalytic residues [active] 479435010125 dimer interface [polypeptide binding]; other site 479435010126 Dienelactone hydrolase family; Region: DLH; pfam01738 479435010127 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435010128 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 479435010129 dimer interface [polypeptide binding]; other site 479435010130 active site 479435010131 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435010132 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 479435010133 substrate binding site [chemical binding]; other site 479435010134 oxyanion hole (OAH) forming residues; other site 479435010135 trimer interface [polypeptide binding]; other site 479435010136 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435010137 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435010138 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 479435010139 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435010140 active site 479435010141 NTP binding site [chemical binding]; other site 479435010142 metal binding triad [ion binding]; metal-binding site 479435010143 antibiotic binding site [chemical binding]; other site 479435010144 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 479435010145 amino acid transporter; Region: 2A0306; TIGR00909 479435010146 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 479435010147 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 479435010148 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 479435010149 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 479435010150 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 479435010151 TPP-binding site; other site 479435010152 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 479435010153 PYR/PP interface [polypeptide binding]; other site 479435010154 dimer interface [polypeptide binding]; other site 479435010155 TPP binding site [chemical binding]; other site 479435010156 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435010157 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 479435010158 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 479435010159 NAD binding site [chemical binding]; other site 479435010160 substrate binding site [chemical binding]; other site 479435010161 homodimer interface [polypeptide binding]; other site 479435010162 active site 479435010163 Protein of unknown function (DUF402); Region: DUF402; cl00979 479435010164 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 479435010165 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 479435010166 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 479435010167 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 479435010168 nucleotide binding site/active site [active] 479435010169 HIT family signature motif; other site 479435010170 catalytic residue [active] 479435010171 YCII-related domain; Region: YCII; cl00999 479435010172 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435010173 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435010174 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435010175 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435010176 HEAT repeats; Region: HEAT_2; pfam13646 479435010177 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 479435010178 active site 479435010179 aconitate hydratase; Validated; Region: PRK09277 479435010180 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 479435010181 substrate binding site [chemical binding]; other site 479435010182 ligand binding site [chemical binding]; other site 479435010183 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 479435010184 substrate binding site [chemical binding]; other site 479435010185 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435010186 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435010187 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 479435010188 TRAM domain; Region: TRAM; pfam01938 479435010189 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 479435010190 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435010191 S-adenosylmethionine binding site [chemical binding]; other site 479435010192 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435010193 TrkA-N domain; Region: TrkA_N; pfam02254 479435010194 TrkA-C domain; Region: TrkA_C; pfam02080 479435010195 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435010196 TrkA-N domain; Region: TrkA_N; pfam02254 479435010197 TrkA-C domain; Region: TrkA_C; pfam02080 479435010198 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 479435010199 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 479435010200 generic binding surface II; other site 479435010201 ssDNA binding site; other site 479435010202 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 479435010203 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 479435010204 trimer interface [polypeptide binding]; other site 479435010205 active site 479435010206 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 479435010207 active site 2 [active] 479435010208 active site 1 [active] 479435010209 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 479435010210 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 479435010211 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 479435010212 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479435010213 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479435010214 active site 479435010215 dimerization interface [polypeptide binding]; other site 479435010216 ferrochelatase; Reviewed; Region: hemH; PRK00035 479435010217 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 479435010218 C-terminal domain interface [polypeptide binding]; other site 479435010219 active site 479435010220 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 479435010221 active site 479435010222 N-terminal domain interface [polypeptide binding]; other site 479435010223 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435010224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010225 Predicted membrane protein [Function unknown]; Region: COG2860 479435010226 UPF0126 domain; Region: UPF0126; pfam03458 479435010227 UPF0126 domain; Region: UPF0126; pfam03458 479435010228 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435010229 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 479435010230 active site 479435010231 catalytic residues [active] 479435010232 metal binding site [ion binding]; metal-binding site 479435010233 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 479435010234 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 479435010235 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010236 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435010237 DNA binding residues [nucleotide binding] 479435010238 Putative zinc-finger; Region: zf-HC2; pfam13490 479435010239 Anti-sigma-K factor rskA; Region: RskA; pfam10099 479435010240 AAA domain; Region: AAA_23; pfam13476 479435010241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435010242 Walker A/P-loop; other site 479435010243 ATP binding site [chemical binding]; other site 479435010244 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 479435010245 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 479435010246 active site 479435010247 metal binding site [ion binding]; metal-binding site 479435010248 DNA binding site [nucleotide binding] 479435010249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435010250 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435010251 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 479435010252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435010253 S-adenosylmethionine binding site [chemical binding]; other site 479435010254 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435010255 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435010256 DNA binding residues [nucleotide binding] 479435010257 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 479435010258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435010259 Walker A/P-loop; other site 479435010260 ATP binding site [chemical binding]; other site 479435010261 Q-loop/lid; other site 479435010262 ABC transporter signature motif; other site 479435010263 Walker B; other site 479435010264 D-loop; other site 479435010265 H-loop/switch region; other site 479435010266 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479435010267 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435010268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435010269 Walker A/P-loop; other site 479435010270 ATP binding site [chemical binding]; other site 479435010271 Q-loop/lid; other site 479435010272 ABC transporter signature motif; other site 479435010273 Walker B; other site 479435010274 D-loop; other site 479435010275 H-loop/switch region; other site 479435010276 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479435010277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435010278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435010279 dimer interface [polypeptide binding]; other site 479435010280 conserved gate region; other site 479435010281 putative PBP binding loops; other site 479435010282 ABC-ATPase subunit interface; other site 479435010283 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 479435010284 peptide binding site [polypeptide binding]; other site 479435010285 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435010286 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435010287 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435010288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435010289 dimer interface [polypeptide binding]; other site 479435010290 conserved gate region; other site 479435010291 putative PBP binding loops; other site 479435010292 ABC-ATPase subunit interface; other site 479435010293 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 479435010294 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435010295 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 479435010296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435010297 active site 479435010298 motif I; other site 479435010299 motif II; other site 479435010300 PAC2 family; Region: PAC2; pfam09754 479435010301 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 479435010302 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435010303 DNA binding residues [nucleotide binding] 479435010304 putative dimer interface [polypeptide binding]; other site 479435010305 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 479435010306 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 479435010307 putative active site [active] 479435010308 putative catalytic site [active] 479435010309 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435010310 short chain dehydrogenase; Validated; Region: PRK08264 479435010311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010312 NAD(P) binding site [chemical binding]; other site 479435010313 active site 479435010314 Cupin; Region: Cupin_6; pfam12852 479435010315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435010317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010318 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 479435010319 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 479435010320 active site 479435010321 HIGH motif; other site 479435010322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 479435010323 active site 479435010324 KMSKS motif; other site 479435010325 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010326 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435010327 NAD(P) binding site [chemical binding]; other site 479435010328 active site 479435010329 Cupin; Region: Cupin_6; pfam12852 479435010330 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435010331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010332 conserved hypothetical protein; Region: TIGR03843 479435010333 conserved hypothetical protein; Region: TIGR03847 479435010334 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435010335 catalytic core [active] 479435010336 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479435010337 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 479435010338 oligomer interface [polypeptide binding]; other site 479435010339 metal binding site [ion binding]; metal-binding site 479435010340 metal binding site [ion binding]; metal-binding site 479435010341 putative Cl binding site [ion binding]; other site 479435010342 basic sphincter; other site 479435010343 hydrophobic gate; other site 479435010344 periplasmic entrance; other site 479435010345 Bacitracin resistance protein BacA; Region: BacA; pfam02673 479435010346 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 479435010347 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435010348 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435010349 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435010350 active site 479435010351 catalytic tetrad [active] 479435010352 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 479435010353 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435010354 ATP binding site [chemical binding]; other site 479435010355 putative Mg++ binding site [ion binding]; other site 479435010356 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435010357 nucleotide binding region [chemical binding]; other site 479435010358 ATP-binding site [chemical binding]; other site 479435010359 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435010360 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435010361 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010362 dimerization interface [polypeptide binding]; other site 479435010363 hypothetical protein; Provisional; Region: PRK07906 479435010364 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 479435010365 putative metal binding site [ion binding]; other site 479435010366 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 479435010367 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435010368 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 479435010369 hydrophobic ligand binding site; other site 479435010370 Cytochrome P450; Region: p450; cl12078 479435010371 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479435010372 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435010373 hydroxyglutarate oxidase; Provisional; Region: PRK11728 479435010374 short chain dehydrogenase; Provisional; Region: PRK06181 479435010375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010376 NAD(P) binding site [chemical binding]; other site 479435010377 active site 479435010378 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 479435010379 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435010380 Transcriptional regulator PadR-like family; Region: PadR; cl17335 479435010381 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 479435010382 Glyco_18 domain; Region: Glyco_18; smart00636 479435010383 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479435010384 active site 479435010385 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435010386 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435010387 putative sugar binding sites [chemical binding]; other site 479435010388 Q-X-W motif; other site 479435010389 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435010390 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435010391 MarR family; Region: MarR_2; cl17246 479435010392 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 479435010393 active site 479435010394 catalytic triad [active] 479435010395 oxyanion hole [active] 479435010396 Putative catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases which consist of a 5-stranded beta/alpha barrel; Region: CE4_DAC_u3_5s; cd10972 479435010397 putative active site [active] 479435010398 putative metal binding site [ion binding]; other site 479435010399 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435010400 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435010401 putative sugar binding sites [chemical binding]; other site 479435010402 Q-X-W motif; other site 479435010403 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479435010404 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435010405 dimerization interface [polypeptide binding]; other site 479435010406 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435010407 GAF domain; Region: GAF; pfam01590 479435010408 ANTAR domain; Region: ANTAR; pfam03861 479435010409 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479435010410 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 479435010411 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 479435010412 FAD binding pocket [chemical binding]; other site 479435010413 FAD binding motif [chemical binding]; other site 479435010414 phosphate binding motif [ion binding]; other site 479435010415 beta-alpha-beta structure motif; other site 479435010416 NAD binding pocket [chemical binding]; other site 479435010417 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435010418 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 479435010419 catalytic loop [active] 479435010420 iron binding site [ion binding]; other site 479435010421 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 479435010422 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 479435010423 putative di-iron ligands [ion binding]; other site 479435010424 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435010425 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435010426 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435010427 GAF domain; Region: GAF; pfam01590 479435010428 GAF domain; Region: GAF_2; pfam13185 479435010429 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435010430 AAA domain; Region: AAA_22; pfam13401 479435010431 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479435010432 active site 479435010433 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 479435010434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435010435 putative active site [active] 479435010436 putative metal binding site [ion binding]; other site 479435010437 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435010438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435010439 DNA-binding site [nucleotide binding]; DNA binding site 479435010440 UTRA domain; Region: UTRA; pfam07702 479435010441 Phosphate transporter family; Region: PHO4; pfam01384 479435010442 Phytase; Region: Phytase; cl17685 479435010443 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435010444 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 479435010445 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 479435010446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435010447 dimer interface [polypeptide binding]; other site 479435010448 conserved gate region; other site 479435010449 putative PBP binding loops; other site 479435010450 ABC-ATPase subunit interface; other site 479435010451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435010452 ABC-ATPase subunit interface; other site 479435010453 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 479435010454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435010455 Walker A/P-loop; other site 479435010456 ATP binding site [chemical binding]; other site 479435010457 Q-loop/lid; other site 479435010458 ABC transporter signature motif; other site 479435010459 Walker B; other site 479435010460 D-loop; other site 479435010461 H-loop/switch region; other site 479435010462 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435010463 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435010464 motif II; other site 479435010465 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479435010466 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479435010467 active site 479435010468 dimerization interface [polypeptide binding]; other site 479435010469 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 479435010470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435010471 active site 479435010472 motif I; other site 479435010473 motif II; other site 479435010474 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 479435010475 GAF domain; Region: GAF; pfam01590 479435010476 GAF domain; Region: GAF_2; pfam13185 479435010477 ANTAR domain; Region: ANTAR; pfam03861 479435010478 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 479435010479 iron-sulfur cluster [ion binding]; other site 479435010480 [2Fe-2S] cluster binding site [ion binding]; other site 479435010481 Uncharacterized conserved protein [Function unknown]; Region: COG3349 479435010482 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435010483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435010484 S-adenosylmethionine binding site [chemical binding]; other site 479435010485 ubiquinone biosynthesis methyltransferase; Region: PLN02232 479435010486 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 479435010487 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 479435010488 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 479435010489 active site lid residues [active] 479435010490 substrate binding pocket [chemical binding]; other site 479435010491 catalytic residues [active] 479435010492 substrate-Mg2+ binding site; other site 479435010493 aspartate-rich region 1; other site 479435010494 aspartate-rich region 2; other site 479435010495 phytoene desaturase; Region: crtI_fam; TIGR02734 479435010496 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435010497 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435010498 substrate binding pocket [chemical binding]; other site 479435010499 chain length determination region; other site 479435010500 substrate-Mg2+ binding site; other site 479435010501 catalytic residues [active] 479435010502 aspartate-rich region 1; other site 479435010503 active site lid residues [active] 479435010504 aspartate-rich region 2; other site 479435010505 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479435010506 heme bH binding site [chemical binding]; other site 479435010507 Qi binding site; other site 479435010508 intrachain domain interface; other site 479435010509 heme bL binding site [chemical binding]; other site 479435010510 interchain domain interface [polypeptide binding]; other site 479435010511 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 479435010512 Qo binding site; other site 479435010513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010515 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 479435010516 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 479435010517 NAD(P) binding pocket [chemical binding]; other site 479435010518 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 479435010519 YCII-related domain; Region: YCII; cl00999 479435010520 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435010521 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435010522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010523 putative substrate translocation pore; other site 479435010524 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435010525 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 479435010526 homodimer interface [polypeptide binding]; other site 479435010527 active site 479435010528 TDP-binding site; other site 479435010529 acceptor substrate-binding pocket; other site 479435010530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010531 putative substrate translocation pore; other site 479435010532 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435010533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435010534 S-adenosylmethionine binding site [chemical binding]; other site 479435010535 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 479435010536 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435010537 non-specific DNA binding site [nucleotide binding]; other site 479435010538 salt bridge; other site 479435010539 sequence-specific DNA binding site [nucleotide binding]; other site 479435010540 Cupin domain; Region: Cupin_2; pfam07883 479435010541 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435010542 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010543 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435010544 DNA binding residues [nucleotide binding] 479435010545 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435010546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435010547 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435010548 Part of AAA domain; Region: AAA_19; pfam13245 479435010549 Family description; Region: UvrD_C_2; pfam13538 479435010550 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 479435010551 Low molecular weight phosphatase family; Region: LMWPc; cd00115 479435010552 active site 479435010553 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 479435010554 amphipathic channel; other site 479435010555 Asn-Pro-Ala signature motifs; other site 479435010556 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010557 putative DNA binding site [nucleotide binding]; other site 479435010558 putative Zn2+ binding site [ion binding]; other site 479435010559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479435010560 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010561 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010562 WHG domain; Region: WHG; pfam13305 479435010563 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010564 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010565 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435010566 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435010567 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435010568 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435010569 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435010570 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010571 dimerization interface [polypeptide binding]; other site 479435010572 putative DNA binding site [nucleotide binding]; other site 479435010573 putative Zn2+ binding site [ion binding]; other site 479435010574 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435010575 anti sigma factor interaction site; other site 479435010576 regulatory phosphorylation site [posttranslational modification]; other site 479435010577 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435010578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435010579 active site 479435010580 phosphorylation site [posttranslational modification] 479435010581 intermolecular recognition site; other site 479435010582 dimerization interface [polypeptide binding]; other site 479435010583 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435010584 DNA binding site [nucleotide binding] 479435010585 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435010586 dimerization interface [polypeptide binding]; other site 479435010587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435010588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435010589 dimer interface [polypeptide binding]; other site 479435010590 phosphorylation site [posttranslational modification] 479435010591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435010592 ATP binding site [chemical binding]; other site 479435010593 Mg2+ binding site [ion binding]; other site 479435010594 G-X-G motif; other site 479435010595 Sporulation and spore germination; Region: Germane; pfam10646 479435010596 Carboxylesterase family; Region: COesterase; pfam00135 479435010597 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479435010598 substrate binding pocket [chemical binding]; other site 479435010599 catalytic triad [active] 479435010600 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010601 putative DNA binding site [nucleotide binding]; other site 479435010602 putative Zn2+ binding site [ion binding]; other site 479435010603 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435010604 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 479435010605 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479435010606 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 479435010607 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479435010608 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435010609 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cl00216 479435010610 active site 479435010611 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 479435010612 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435010613 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 479435010614 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 479435010615 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435010616 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435010617 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 479435010618 putative dimer interface [polypeptide binding]; other site 479435010619 ligand binding site [chemical binding]; other site 479435010620 Zn binding site [ion binding]; other site 479435010621 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435010622 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435010623 active site 479435010624 catalytic site [active] 479435010625 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435010626 dinuclear metal binding motif [ion binding]; other site 479435010627 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435010628 dinuclear metal binding motif [ion binding]; other site 479435010629 Putative zinc-finger; Region: zf-HC2; pfam13490 479435010630 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435010631 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010632 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435010633 DNA binding residues [nucleotide binding] 479435010634 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 479435010635 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 479435010636 dimanganese center [ion binding]; other site 479435010637 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 479435010638 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435010639 YCII-related domain; Region: YCII; cl00999 479435010640 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 479435010641 Cupin; Region: Cupin_6; pfam12852 479435010642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010643 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435010644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435010645 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479435010646 beta-galactosidase; Region: BGL; TIGR03356 479435010647 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435010648 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010649 putative DNA binding site [nucleotide binding]; other site 479435010650 dimerization interface [polypeptide binding]; other site 479435010651 putative Zn2+ binding site [ion binding]; other site 479435010652 RibD C-terminal domain; Region: RibD_C; cl17279 479435010653 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435010654 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435010655 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435010656 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 479435010657 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 479435010658 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435010659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010661 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 479435010662 classical (c) SDRs; Region: SDR_c; cd05233 479435010663 NAD(P) binding site [chemical binding]; other site 479435010664 active site 479435010665 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435010666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010667 dimerization interface [polypeptide binding]; other site 479435010668 putative DNA binding site [nucleotide binding]; other site 479435010669 putative Zn2+ binding site [ion binding]; other site 479435010670 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435010671 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435010672 active site 479435010673 ATP binding site [chemical binding]; other site 479435010674 substrate binding site [chemical binding]; other site 479435010675 activation loop (A-loop); other site 479435010676 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 479435010677 AAA domain; Region: AAA_30; pfam13604 479435010678 Family description; Region: UvrD_C_2; pfam13538 479435010679 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 479435010680 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 479435010681 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 479435010682 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 479435010683 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435010684 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435010685 DNA binding site [nucleotide binding] 479435010686 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 479435010687 ligand binding site [chemical binding]; other site 479435010688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435010689 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435010690 putative substrate translocation pore; other site 479435010691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435010692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435010693 DNA binding site [nucleotide binding] 479435010694 domain linker motif; other site 479435010695 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435010696 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 479435010697 Radical SAM superfamily; Region: Radical_SAM; pfam04055 479435010698 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435010699 putative metal binding site [ion binding]; other site 479435010700 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435010701 putative catalytic site [active] 479435010702 putative phosphate binding site [ion binding]; other site 479435010703 putative metal binding site [ion binding]; other site 479435010704 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435010705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435010706 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435010707 putative dimerization interface [polypeptide binding]; other site 479435010708 EamA-like transporter family; Region: EamA; pfam00892 479435010709 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 479435010710 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 479435010711 putative NAD(P) binding site [chemical binding]; other site 479435010712 putative substrate binding site [chemical binding]; other site 479435010713 catalytic Zn binding site [ion binding]; other site 479435010714 structural Zn binding site [ion binding]; other site 479435010715 dimer interface [polypeptide binding]; other site 479435010716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010718 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435010719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435010720 Walker A/P-loop; other site 479435010721 ATP binding site [chemical binding]; other site 479435010722 Q-loop/lid; other site 479435010723 ABC transporter signature motif; other site 479435010724 Walker B; other site 479435010725 D-loop; other site 479435010726 H-loop/switch region; other site 479435010727 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435010728 catalytic core [active] 479435010729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435010730 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435010731 active site 479435010732 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435010733 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435010734 active site 479435010735 metal binding site [ion binding]; metal-binding site 479435010736 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479435010737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435010738 motif II; other site 479435010739 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435010740 active site 479435010741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435010742 S-adenosylmethionine binding site [chemical binding]; other site 479435010743 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 479435010744 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 479435010745 nucleotide binding pocket [chemical binding]; other site 479435010746 K-X-D-G motif; other site 479435010747 catalytic site [active] 479435010748 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 479435010749 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 479435010750 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 479435010751 Dimer interface [polypeptide binding]; other site 479435010752 BRCT sequence motif; other site 479435010753 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 479435010754 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 479435010755 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 479435010756 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 479435010757 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 479435010758 Glucose dehydrogenase; Region: glucose_DH; cd08230 479435010759 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435010760 NADP binding site [chemical binding]; other site 479435010761 catalytic Zn binding site [ion binding]; other site 479435010762 structural Zn binding site [ion binding]; other site 479435010763 dimer interface [polypeptide binding]; other site 479435010764 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479435010765 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 479435010766 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 479435010767 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 479435010768 active site 479435010769 PHP Thumb interface [polypeptide binding]; other site 479435010770 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 479435010771 generic binding surface II; other site 479435010772 generic binding surface I; other site 479435010773 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 479435010774 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 479435010775 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435010776 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435010777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435010778 dimer interface [polypeptide binding]; other site 479435010779 conserved gate region; other site 479435010780 ABC-ATPase subunit interface; other site 479435010781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435010782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435010783 putative PBP binding loops; other site 479435010784 dimer interface [polypeptide binding]; other site 479435010785 ABC-ATPase subunit interface; other site 479435010786 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435010787 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 479435010788 Walker A/P-loop; other site 479435010789 ATP binding site [chemical binding]; other site 479435010790 Q-loop/lid; other site 479435010791 ABC transporter signature motif; other site 479435010792 Walker B; other site 479435010793 D-loop; other site 479435010794 H-loop/switch region; other site 479435010795 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435010796 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 479435010797 Walker A/P-loop; other site 479435010798 ATP binding site [chemical binding]; other site 479435010799 Q-loop/lid; other site 479435010800 ABC transporter signature motif; other site 479435010801 Walker B; other site 479435010802 D-loop; other site 479435010803 H-loop/switch region; other site 479435010804 Cupin domain; Region: Cupin_2; pfam07883 479435010805 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435010806 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435010807 DNA binding residues [nucleotide binding] 479435010808 dimer interface [polypeptide binding]; other site 479435010809 Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695 479435010810 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 479435010811 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 479435010812 putative dimer interface [polypeptide binding]; other site 479435010813 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435010814 DinB superfamily; Region: DinB_2; pfam12867 479435010815 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 479435010816 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435010817 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435010818 AAA ATPase domain; Region: AAA_16; pfam13191 479435010819 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010820 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435010821 DNA binding residues [nucleotide binding] 479435010822 dimerization interface [polypeptide binding]; other site 479435010823 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 479435010824 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435010825 Walker A/P-loop; other site 479435010826 ATP binding site [chemical binding]; other site 479435010827 Q-loop/lid; other site 479435010828 ABC transporter signature motif; other site 479435010829 Walker B; other site 479435010830 D-loop; other site 479435010831 H-loop/switch region; other site 479435010832 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435010833 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435010834 ATP binding site [chemical binding]; other site 479435010835 putative Mg++ binding site [ion binding]; other site 479435010836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435010837 nucleotide binding region [chemical binding]; other site 479435010838 ATP-binding site [chemical binding]; other site 479435010839 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 479435010840 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 479435010841 active site 479435010842 DNA binding site [nucleotide binding] 479435010843 Int/Topo IB signature motif; other site 479435010844 oxidoreductase; Provisional; Region: PRK06196 479435010845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435010846 NAD(P) binding site [chemical binding]; other site 479435010847 active site 479435010848 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 479435010849 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435010850 tetramer interface [polypeptide binding]; other site 479435010851 active site 479435010852 Mg2+/Mn2+ binding site [ion binding]; other site 479435010853 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435010854 active site 479435010855 metal binding site [ion binding]; metal-binding site 479435010856 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435010857 putative hydrophobic ligand binding site [chemical binding]; other site 479435010858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435010859 Coenzyme A binding pocket [chemical binding]; other site 479435010860 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 479435010861 active site 479435010862 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435010863 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435010864 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 479435010865 active site 479435010866 catalytic triad [active] 479435010867 oxyanion hole [active] 479435010868 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435010869 enolase; Provisional; Region: eno; PRK00077 479435010870 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 479435010871 dimer interface [polypeptide binding]; other site 479435010872 metal binding site [ion binding]; metal-binding site 479435010873 substrate binding pocket [chemical binding]; other site 479435010874 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435010875 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435010876 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435010877 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 479435010878 DNA binding residues [nucleotide binding] 479435010879 dimer interface [polypeptide binding]; other site 479435010880 Methyltransferase domain; Region: Methyltransf_11; pfam08241 479435010881 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435010882 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010883 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435010884 DNA binding residues [nucleotide binding] 479435010885 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 479435010886 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435010887 MarR family; Region: MarR_2; pfam12802 479435010888 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 479435010889 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435010890 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435010891 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435010892 dimerization interface [polypeptide binding]; other site 479435010893 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 479435010894 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 479435010895 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 479435010896 tyrosine decarboxylase; Region: PLN02880 479435010897 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435010898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435010899 catalytic residue [active] 479435010900 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 479435010901 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435010902 YCII-related domain; Region: YCII; cl00999 479435010903 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435010904 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435010905 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435010906 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 479435010907 cystathionine gamma-lyase; Validated; Region: PRK07582 479435010908 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435010909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435010910 catalytic residue [active] 479435010911 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828 479435010912 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435010913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010916 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010917 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 479435010918 active site 479435010919 Zn binding site [ion binding]; other site 479435010920 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 479435010921 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435010922 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435010923 amidase; Provisional; Region: PRK07869 479435010924 Amidase; Region: Amidase; cl11426 479435010925 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435010926 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435010927 AAA domain; Region: AAA_33; pfam13671 479435010928 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 479435010929 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435010930 Predicted ATPase [General function prediction only]; Region: COG3903 479435010931 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479435010932 classical (c) SDRs; Region: SDR_c; cd05233 479435010933 NAD(P) binding site [chemical binding]; other site 479435010934 active site 479435010935 Domain of unknown function (DUF385); Region: DUF385; pfam04075 479435010936 Family description; Region: VCBS; pfam13517 479435010937 photosynthetic reaction center subunit L; Provisional; Region: PRK14506 479435010938 Family description; Region: VCBS; pfam13517 479435010939 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435010940 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435010941 putative sugar binding sites [chemical binding]; other site 479435010942 Q-X-W motif; other site 479435010943 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435010944 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435010945 putative sugar binding sites [chemical binding]; other site 479435010946 Q-X-W motif; other site 479435010947 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 479435010948 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 479435010949 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 479435010950 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435010951 dimerization interface [polypeptide binding]; other site 479435010952 putative DNA binding site [nucleotide binding]; other site 479435010953 putative Zn2+ binding site [ion binding]; other site 479435010954 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435010955 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435010956 DNA binding residues [nucleotide binding] 479435010957 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435010958 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435010959 Coenzyme A binding pocket [chemical binding]; other site 479435010960 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435010961 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435010962 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435010963 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 479435010964 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 479435010965 active site 1 [active] 479435010966 dimer interface [polypeptide binding]; other site 479435010967 hexamer interface [polypeptide binding]; other site 479435010968 active site 2 [active] 479435010969 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479435010970 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 479435010971 active site 479435010972 catalytic site [active] 479435010973 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 479435010974 starch-binding site 2 [chemical binding]; other site 479435010975 starch-binding site 1 [chemical binding]; other site 479435010976 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 479435010977 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 479435010978 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 479435010979 active site 479435010980 catalytic site [active] 479435010981 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435010982 putative metal binding site [ion binding]; other site 479435010983 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 479435010984 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435010985 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435010986 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435010987 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435010988 AAA ATPase domain; Region: AAA_16; pfam13191 479435010989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435010990 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435010991 DNA binding residues [nucleotide binding] 479435010992 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 479435010993 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 479435010994 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 479435010995 GAF domain; Region: GAF_3; pfam13492 479435010996 GAF domain; Region: GAF_2; pfam13185 479435010997 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435010998 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 479435010999 Fasciclin domain; Region: Fasciclin; pfam02469 479435011000 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 479435011001 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435011002 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 479435011003 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435011004 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 479435011005 putative active site [active] 479435011006 Phosphotransferase enzyme family; Region: APH; pfam01636 479435011007 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435011008 active site 479435011009 ATP binding site [chemical binding]; other site 479435011010 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 479435011011 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 479435011012 putative DNA binding helix; other site 479435011013 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435011014 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 479435011015 intersubunit interface [polypeptide binding]; other site 479435011016 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 479435011017 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 479435011018 ABC-ATPase subunit interface; other site 479435011019 dimer interface [polypeptide binding]; other site 479435011020 putative PBP binding regions; other site 479435011021 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 479435011022 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 479435011023 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 479435011024 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 479435011025 putative ligand binding residues [chemical binding]; other site 479435011026 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435011027 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435011028 Walker A/P-loop; other site 479435011029 ATP binding site [chemical binding]; other site 479435011030 Q-loop/lid; other site 479435011031 ABC transporter signature motif; other site 479435011032 Walker B; other site 479435011033 D-loop; other site 479435011034 H-loop/switch region; other site 479435011035 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 479435011036 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435011037 ABC-ATPase subunit interface; other site 479435011038 dimer interface [polypeptide binding]; other site 479435011039 putative PBP binding regions; other site 479435011040 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435011041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011042 S-adenosylmethionine binding site [chemical binding]; other site 479435011043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011044 S-adenosylmethionine binding site [chemical binding]; other site 479435011045 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435011046 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435011047 active site 479435011048 catalytic tetrad [active] 479435011049 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435011050 DNA binding site [nucleotide binding] 479435011051 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435011052 Predicted ATPase [General function prediction only]; Region: COG3903 479435011053 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435011054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011055 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 479435011056 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435011057 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435011058 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435011060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011061 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435011062 NAD(P) binding site [chemical binding]; other site 479435011063 active site 479435011064 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 479435011065 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435011066 putative NAD(P) binding site [chemical binding]; other site 479435011067 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479435011068 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011069 NAD(P) binding site [chemical binding]; other site 479435011070 active site 479435011071 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435011072 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 479435011073 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435011074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011075 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435011076 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435011077 putative NAD(P) binding site [chemical binding]; other site 479435011078 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435011079 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435011080 putative DNA binding site [nucleotide binding]; other site 479435011081 putative Zn2+ binding site [ion binding]; other site 479435011082 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435011083 Cytochrome P450; Region: p450; cl12078 479435011084 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 479435011085 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 479435011086 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 479435011087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435011088 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 479435011089 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011091 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435011092 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435011093 active site 479435011094 catalytic tetrad [active] 479435011095 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 479435011096 classical (c) SDRs; Region: SDR_c; cd05233 479435011097 NAD(P) binding site [chemical binding]; other site 479435011098 active site 479435011099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435011100 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011101 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 479435011102 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 479435011103 MbtH-like protein; Region: MbtH; cl01279 479435011104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435011105 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435011106 acyl-activating enzyme (AAE) consensus motif; other site 479435011107 AMP binding site [chemical binding]; other site 479435011108 Condensation domain; Region: Condensation; pfam00668 479435011109 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435011110 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435011111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011112 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011113 Condensation domain; Region: Condensation; pfam00668 479435011114 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435011115 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435011116 Condensation domain; Region: Condensation; pfam00668 479435011117 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435011118 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435011119 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435011120 acyl-activating enzyme (AAE) consensus motif; other site 479435011121 AMP binding site [chemical binding]; other site 479435011122 active site 479435011123 CoA binding site [chemical binding]; other site 479435011124 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011126 DNA binding residues [nucleotide binding] 479435011127 dimerization interface [polypeptide binding]; other site 479435011128 Condensation domain; Region: Condensation; pfam00668 479435011129 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435011130 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435011131 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 479435011132 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435011133 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435011134 acyl-activating enzyme (AAE) consensus motif; other site 479435011135 AMP binding site [chemical binding]; other site 479435011136 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435011138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435011139 non-specific DNA binding site [nucleotide binding]; other site 479435011140 salt bridge; other site 479435011141 sequence-specific DNA binding site [nucleotide binding]; other site 479435011142 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435011143 Cytochrome P450; Region: p450; cl12078 479435011144 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435011145 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435011146 acyl-activating enzyme (AAE) consensus motif; other site 479435011147 AMP binding site [chemical binding]; other site 479435011148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011149 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011150 NAD(P) binding site [chemical binding]; other site 479435011151 active site 479435011152 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435011153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435011154 active site 479435011155 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435011156 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435011157 acyl-activating enzyme (AAE) consensus motif; other site 479435011158 AMP binding site [chemical binding]; other site 479435011159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011160 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 479435011161 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 479435011162 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 479435011163 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435011164 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 479435011165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435011166 homodimer interface [polypeptide binding]; other site 479435011167 catalytic residue [active] 479435011168 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 479435011169 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435011170 substrate binding site [chemical binding]; other site 479435011171 oxyanion hole (OAH) forming residues; other site 479435011172 trimer interface [polypeptide binding]; other site 479435011173 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435011174 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 479435011175 trimer interface [polypeptide binding]; other site 479435011176 oxyanion hole (OAH) forming residues; other site 479435011177 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 479435011178 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479435011179 active site 479435011180 enoyl-CoA hydratase; Provisional; Region: PRK06494 479435011181 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435011182 substrate binding site [chemical binding]; other site 479435011183 oxyanion hole (OAH) forming residues; other site 479435011184 trimer interface [polypeptide binding]; other site 479435011185 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 479435011186 Glutamine amidotransferase class-I; Region: GATase; pfam00117 479435011187 glutamine binding [chemical binding]; other site 479435011188 catalytic triad [active] 479435011189 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 479435011190 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479435011191 chorismate binding enzyme; Region: Chorismate_bind; cl10555 479435011192 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 479435011193 Condensation domain; Region: Condensation; pfam00668 479435011194 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435011195 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435011196 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435011197 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011198 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435011199 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 479435011200 acyl-activating enzyme (AAE) consensus motif; other site 479435011201 AMP binding site [chemical binding]; other site 479435011202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011203 Condensation domain; Region: Condensation; pfam00668 479435011204 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435011205 Nonribosomal peptide synthase; Region: NRPS; pfam08415 479435011206 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 479435011207 acyl-activating enzyme (AAE) consensus motif; other site 479435011208 AMP binding site [chemical binding]; other site 479435011209 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435011211 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435011212 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435011213 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479435011214 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435011215 ligand binding site [chemical binding]; other site 479435011216 flexible hinge region; other site 479435011217 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 479435011218 non-specific DNA interactions [nucleotide binding]; other site 479435011219 DNA binding site [nucleotide binding] 479435011220 sequence specific DNA binding site [nucleotide binding]; other site 479435011221 putative cAMP binding site [chemical binding]; other site 479435011222 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435011223 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435011224 active site 479435011225 catalytic tetrad [active] 479435011226 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 479435011227 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 479435011228 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 479435011229 ligand-binding site [chemical binding]; other site 479435011230 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 479435011231 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 479435011232 Active Sites [active] 479435011233 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 479435011234 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 479435011235 G1 box; other site 479435011236 putative GEF interaction site [polypeptide binding]; other site 479435011237 GTP/Mg2+ binding site [chemical binding]; other site 479435011238 Switch I region; other site 479435011239 G2 box; other site 479435011240 CysD dimerization site [polypeptide binding]; other site 479435011241 G3 box; other site 479435011242 Switch II region; other site 479435011243 G4 box; other site 479435011244 G5 box; other site 479435011245 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 479435011246 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 479435011247 Phosphotransferase enzyme family; Region: APH; pfam01636 479435011248 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435011249 ATP binding site [chemical binding]; other site 479435011250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011251 putative substrate translocation pore; other site 479435011252 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 479435011253 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 479435011254 [4Fe-4S] binding site [ion binding]; other site 479435011255 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479435011256 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479435011257 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 479435011258 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 479435011259 molybdopterin cofactor binding site; other site 479435011260 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 479435011261 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 479435011262 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 479435011263 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 479435011264 Cupin superfamily protein; Region: Cupin_4; pfam08007 479435011265 Cupin-like domain; Region: Cupin_8; pfam13621 479435011266 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 479435011267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011268 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435011269 SnoaL-like domain; Region: SnoaL_4; pfam13577 479435011270 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435011271 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011272 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435011273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435011274 DNA binding site [nucleotide binding] 479435011275 domain linker motif; other site 479435011276 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435011277 ligand binding site [chemical binding]; other site 479435011278 dimerization interface [polypeptide binding]; other site 479435011279 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435011280 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435011281 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435011282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435011283 dimer interface [polypeptide binding]; other site 479435011284 conserved gate region; other site 479435011285 ABC-ATPase subunit interface; other site 479435011286 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435011288 dimer interface [polypeptide binding]; other site 479435011289 conserved gate region; other site 479435011290 putative PBP binding loops; other site 479435011291 ABC-ATPase subunit interface; other site 479435011292 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 479435011293 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435011294 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 479435011295 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435011296 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 479435011297 CopC domain; Region: CopC; pfam04234 479435011298 Copper resistance protein D; Region: CopD; pfam05425 479435011299 YtkA-like; Region: YtkA; pfam13115 479435011300 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 479435011301 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 479435011302 active site 1 [active] 479435011303 dimer interface [polypeptide binding]; other site 479435011304 hexamer interface [polypeptide binding]; other site 479435011305 active site 2 [active] 479435011306 Trehalose utilisation; Region: ThuA; pfam06283 479435011307 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 479435011308 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479435011309 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 479435011310 VCBS repeat; Region: VCBS_repeat; TIGR01965 479435011311 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435011312 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435011313 NAD(P) binding site [chemical binding]; other site 479435011314 catalytic residues [active] 479435011315 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435011316 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435011317 TM-ABC transporter signature motif; other site 479435011318 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435011319 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435011320 Walker A/P-loop; other site 479435011321 ATP binding site [chemical binding]; other site 479435011322 Q-loop/lid; other site 479435011323 ABC transporter signature motif; other site 479435011324 Walker B; other site 479435011325 D-loop; other site 479435011326 H-loop/switch region; other site 479435011327 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479435011328 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435011329 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435011330 TM-ABC transporter signature motif; other site 479435011331 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479435011332 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479435011333 ligand binding site [chemical binding]; other site 479435011334 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 479435011335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011336 NAD(P) binding site [chemical binding]; other site 479435011337 active site 479435011338 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 479435011339 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435011340 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435011341 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435011342 LGFP repeat; Region: LGFP; pfam08310 479435011343 LGFP repeat; Region: LGFP; pfam08310 479435011344 LGFP repeat; Region: LGFP; pfam08310 479435011345 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435011346 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435011347 CHAT domain; Region: CHAT; cl17868 479435011348 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 479435011349 active site 479435011350 catalytic residues [active] 479435011351 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435011352 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011353 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435011354 AsnC family; Region: AsnC_trans_reg; pfam01037 479435011355 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435011356 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435011357 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 479435011358 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 479435011359 metal binding site [ion binding]; metal-binding site 479435011360 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435011361 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 479435011362 putative hydrophobic ligand binding site [chemical binding]; other site 479435011363 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435011364 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435011365 Cupin domain; Region: Cupin_2; pfam07883 479435011366 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 479435011367 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 479435011368 NIPSNAP; Region: NIPSNAP; pfam07978 479435011369 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 479435011370 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435011371 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 479435011372 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 479435011373 iron-sulfur cluster [ion binding]; other site 479435011374 [2Fe-2S] cluster binding site [ion binding]; other site 479435011375 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435011376 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435011377 active site 479435011378 Competence-damaged protein; Region: CinA; pfam02464 479435011379 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 479435011380 dimanganese center [ion binding]; other site 479435011381 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 479435011382 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 479435011383 D-pathway; other site 479435011384 Putative ubiquinol binding site [chemical binding]; other site 479435011385 Low-spin heme (heme b) binding site [chemical binding]; other site 479435011386 Putative water exit pathway; other site 479435011387 Binuclear center (heme o3/CuB) [ion binding]; other site 479435011388 K-pathway; other site 479435011389 Putative proton exit pathway; other site 479435011390 ANTAR domain; Region: ANTAR; pfam03861 479435011391 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435011392 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011393 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435011394 DNA binding residues [nucleotide binding] 479435011395 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435011396 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435011397 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435011398 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435011399 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479435011400 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435011401 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 479435011402 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435011403 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435011404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435011405 dimer interface [polypeptide binding]; other site 479435011406 conserved gate region; other site 479435011407 putative PBP binding loops; other site 479435011408 ABC-ATPase subunit interface; other site 479435011409 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435011410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435011411 dimer interface [polypeptide binding]; other site 479435011412 conserved gate region; other site 479435011413 putative PBP binding loops; other site 479435011414 ABC-ATPase subunit interface; other site 479435011415 xylose isomerase; Provisional; Region: PRK12677 479435011416 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 479435011417 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435011418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011419 putative substrate translocation pore; other site 479435011420 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 479435011421 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 479435011422 NAD(P) binding site [chemical binding]; other site 479435011423 catalytic residues [active] 479435011424 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435011425 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435011426 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435011427 non-specific DNA binding site [nucleotide binding]; other site 479435011428 salt bridge; other site 479435011429 sequence-specific DNA binding site [nucleotide binding]; other site 479435011430 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435011431 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 479435011432 putative NAD(P) binding site [chemical binding]; other site 479435011433 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435011434 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 479435011435 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479435011436 AAA ATPase domain; Region: AAA_16; pfam13191 479435011437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011438 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011439 DNA binding residues [nucleotide binding] 479435011440 dimerization interface [polypeptide binding]; other site 479435011441 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 479435011442 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 479435011443 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 479435011444 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435011445 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435011446 substrate binding pocket [chemical binding]; other site 479435011447 chain length determination region; other site 479435011448 substrate-Mg2+ binding site; other site 479435011449 catalytic residues [active] 479435011450 aspartate-rich region 1; other site 479435011451 active site lid residues [active] 479435011452 aspartate-rich region 2; other site 479435011453 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 479435011454 substrate binding pocket [chemical binding]; other site 479435011455 substrate-Mg2+ binding site; other site 479435011456 aspartate-rich region 1; other site 479435011457 aspartate-rich region 2; other site 479435011458 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 479435011459 substrate binding pocket [chemical binding]; other site 479435011460 substrate-Mg2+ binding site; other site 479435011461 aspartate-rich region 1; other site 479435011462 aspartate-rich region 2; other site 479435011463 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479435011464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435011465 ligand binding site [chemical binding]; other site 479435011466 flexible hinge region; other site 479435011467 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 479435011468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435011469 Walker A/P-loop; other site 479435011470 ATP binding site [chemical binding]; other site 479435011471 Q-loop/lid; other site 479435011472 ABC transporter signature motif; other site 479435011473 Walker B; other site 479435011474 D-loop; other site 479435011475 H-loop/switch region; other site 479435011476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 479435011477 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435011478 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 479435011479 Walker A/P-loop; other site 479435011480 ATP binding site [chemical binding]; other site 479435011481 Q-loop/lid; other site 479435011482 ABC transporter signature motif; other site 479435011483 Walker B; other site 479435011484 D-loop; other site 479435011485 H-loop/switch region; other site 479435011486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435011487 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435011488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435011489 dimer interface [polypeptide binding]; other site 479435011490 conserved gate region; other site 479435011491 putative PBP binding loops; other site 479435011492 ABC-ATPase subunit interface; other site 479435011493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435011494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435011495 dimer interface [polypeptide binding]; other site 479435011496 conserved gate region; other site 479435011497 putative PBP binding loops; other site 479435011498 ABC-ATPase subunit interface; other site 479435011499 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435011500 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 479435011501 substrate binding site [chemical binding]; other site 479435011502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011503 S-adenosylmethionine binding site [chemical binding]; other site 479435011504 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 479435011505 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 479435011506 binding surface 479435011507 TPR motif; other site 479435011508 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435011509 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435011510 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 479435011511 putative FMN binding site [chemical binding]; other site 479435011512 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435011513 hydrophobic ligand binding site; other site 479435011514 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435011515 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435011516 active site 479435011517 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435011518 dimerization interface [polypeptide binding]; other site 479435011519 putative DNA binding site [nucleotide binding]; other site 479435011520 putative Zn2+ binding site [ion binding]; other site 479435011521 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435011522 YCII-related domain; Region: YCII; cl00999 479435011523 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435011524 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435011525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435011526 putative Zn2+ binding site [ion binding]; other site 479435011527 putative DNA binding site [nucleotide binding]; other site 479435011528 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435011529 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435011530 DNA binding site [nucleotide binding] 479435011531 domain linker motif; other site 479435011532 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435011533 putative dimerization interface [polypeptide binding]; other site 479435011534 putative ligand binding site [chemical binding]; other site 479435011535 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435011536 sugar binding site [chemical binding]; other site 479435011537 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 479435011538 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435011539 sugar binding site [chemical binding]; other site 479435011540 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 479435011541 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435011542 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 479435011543 Trehalose utilisation; Region: ThuA; pfam06283 479435011544 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 479435011545 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 479435011546 FOG: PKD repeat [General function prediction only]; Region: COG3291 479435011547 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 479435011548 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 479435011549 ligand binding site [chemical binding]; other site 479435011550 metal binding site [ion binding]; metal-binding site 479435011551 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 479435011552 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 479435011553 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 479435011554 xylose isomerase; Provisional; Region: PRK12677 479435011555 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 479435011556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435011557 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435011558 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435011559 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 479435011560 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435011561 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 479435011562 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 479435011563 TM-ABC transporter signature motif; other site 479435011564 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 479435011565 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 479435011566 Walker A/P-loop; other site 479435011567 ATP binding site [chemical binding]; other site 479435011568 Q-loop/lid; other site 479435011569 ABC transporter signature motif; other site 479435011570 Walker B; other site 479435011571 D-loop; other site 479435011572 H-loop/switch region; other site 479435011573 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 479435011574 MarR family; Region: MarR_2; pfam12802 479435011575 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435011576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435011577 nucleotide binding site [chemical binding]; other site 479435011578 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 479435011579 putative ligand binding site [chemical binding]; other site 479435011580 putative catalytic site [active] 479435011581 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435011583 active site 479435011584 phosphorylation site [posttranslational modification] 479435011585 intermolecular recognition site; other site 479435011586 dimerization interface [polypeptide binding]; other site 479435011587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011588 DNA binding residues [nucleotide binding] 479435011589 dimerization interface [polypeptide binding]; other site 479435011590 Histidine kinase; Region: HisKA_3; pfam07730 479435011591 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435011592 CAAX protease self-immunity; Region: Abi; pfam02517 479435011593 MarR family; Region: MarR_2; cl17246 479435011594 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435011595 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435011596 YCII-related domain; Region: YCII; cl00999 479435011597 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 479435011598 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 479435011599 active site 479435011600 catalytic triad [active] 479435011601 Bacterial Ig-like domain; Region: Big_5; pfam13205 479435011602 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 479435011603 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435011604 active site 479435011605 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 479435011606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011607 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435011608 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 479435011609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435011610 Histidine kinase; Region: HisKA_3; pfam07730 479435011611 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435011612 ATP binding site [chemical binding]; other site 479435011613 Mg2+ binding site [ion binding]; other site 479435011614 G-X-G motif; other site 479435011615 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479435011616 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479435011617 active site 479435011618 substrate binding site [chemical binding]; other site 479435011619 FMN binding site [chemical binding]; other site 479435011620 putative catalytic residues [active] 479435011621 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435011622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435011623 DNA-binding site [nucleotide binding]; DNA binding site 479435011624 FCD domain; Region: FCD; pfam07729 479435011625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011626 S-adenosylmethionine binding site [chemical binding]; other site 479435011627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435011628 Histidine kinase; Region: HisKA_3; pfam07730 479435011629 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435011631 active site 479435011632 phosphorylation site [posttranslational modification] 479435011633 intermolecular recognition site; other site 479435011634 dimerization interface [polypeptide binding]; other site 479435011635 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011636 DNA binding residues [nucleotide binding] 479435011637 dimerization interface [polypeptide binding]; other site 479435011638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435011640 active site 479435011641 phosphorylation site [posttranslational modification] 479435011642 intermolecular recognition site; other site 479435011643 dimerization interface [polypeptide binding]; other site 479435011644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011645 DNA binding residues [nucleotide binding] 479435011646 dimerization interface [polypeptide binding]; other site 479435011647 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435011648 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 479435011649 Walker A/P-loop; other site 479435011650 ATP binding site [chemical binding]; other site 479435011651 Q-loop/lid; other site 479435011652 ABC transporter signature motif; other site 479435011653 Walker B; other site 479435011654 D-loop; other site 479435011655 H-loop/switch region; other site 479435011656 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 479435011657 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 479435011658 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435011659 Uncharacterized conserved protein [Function unknown]; Region: COG3538 479435011660 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 479435011661 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 479435011662 putative Zn2+ binding site [ion binding]; other site 479435011663 putative DNA binding site [nucleotide binding]; other site 479435011664 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435011665 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435011666 Melibiase; Region: Melibiase; pfam02065 479435011667 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435011668 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435011669 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435011670 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435011671 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435011672 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435011673 catalytic residue [active] 479435011674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435011675 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435011676 NAD(P) binding site [chemical binding]; other site 479435011677 active site 479435011678 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435011679 EamA-like transporter family; Region: EamA; pfam00892 479435011680 Protein of unknown function, DUF606; Region: DUF606; cl01273 479435011681 Protein of unknown function, DUF606; Region: DUF606; pfam04657 479435011682 16S rRNA methyltransferase B; Provisional; Region: PRK14902 479435011683 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 479435011684 putative RNA binding site [nucleotide binding]; other site 479435011685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011686 S-adenosylmethionine binding site [chemical binding]; other site 479435011687 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 479435011688 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 479435011689 putative active site [active] 479435011690 substrate binding site [chemical binding]; other site 479435011691 putative cosubstrate binding site; other site 479435011692 catalytic site [active] 479435011693 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 479435011694 substrate binding site [chemical binding]; other site 479435011695 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 479435011696 active site 479435011697 catalytic residues [active] 479435011698 metal binding site [ion binding]; metal-binding site 479435011699 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479435011700 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 479435011701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011702 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435011703 putative substrate translocation pore; other site 479435011704 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435011705 dimerization interface [polypeptide binding]; other site 479435011706 putative DNA binding site [nucleotide binding]; other site 479435011707 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435011708 putative Zn2+ binding site [ion binding]; other site 479435011709 Putative cyclase; Region: Cyclase; pfam04199 479435011710 primosome assembly protein PriA; Provisional; Region: PRK14873 479435011711 S-adenosylmethionine synthetase; Validated; Region: PRK05250 479435011712 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 479435011713 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 479435011714 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 479435011715 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435011716 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435011717 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 479435011718 Flavoprotein; Region: Flavoprotein; pfam02441 479435011719 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 479435011720 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 479435011721 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 479435011722 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 479435011723 catalytic site [active] 479435011724 G-X2-G-X-G-K; other site 479435011725 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 479435011726 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 479435011727 active site 479435011728 dimer interface [polypeptide binding]; other site 479435011729 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 479435011730 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 479435011731 quinone interaction residues [chemical binding]; other site 479435011732 active site 479435011733 catalytic residues [active] 479435011734 substrate binding site [chemical binding]; other site 479435011735 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479435011736 phosphate binding site [ion binding]; other site 479435011737 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 479435011738 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435011739 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435011740 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 479435011741 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 479435011742 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435011743 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 479435011744 IMP binding site; other site 479435011745 dimer interface [polypeptide binding]; other site 479435011746 interdomain contacts; other site 479435011747 partial ornithine binding site; other site 479435011748 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 479435011749 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 479435011750 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 479435011751 catalytic site [active] 479435011752 subunit interface [polypeptide binding]; other site 479435011753 dihydroorotase; Validated; Region: pyrC; PRK09357 479435011754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435011755 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 479435011756 active site 479435011757 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 479435011758 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479435011759 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 479435011760 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 479435011761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435011762 active site 479435011763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435011764 non-specific DNA binding site [nucleotide binding]; other site 479435011765 salt bridge; other site 479435011766 sequence-specific DNA binding site [nucleotide binding]; other site 479435011767 transcription antitermination factor NusB; Region: nusB; TIGR01951 479435011768 putative RNA binding site [nucleotide binding]; other site 479435011769 elongation factor P; Validated; Region: PRK00529 479435011770 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 479435011771 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 479435011772 RNA binding site [nucleotide binding]; other site 479435011773 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 479435011774 RNA binding site [nucleotide binding]; other site 479435011775 methyltransferase, FxLD system; Region: methyltran_FxLD; TIGR04364 479435011776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011777 S-adenosylmethionine binding site [chemical binding]; other site 479435011778 MarR family; Region: MarR_2; cl17246 479435011779 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435011780 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 479435011781 EamA-like transporter family; Region: EamA; pfam00892 479435011782 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435011784 active site 479435011785 phosphorylation site [posttranslational modification] 479435011786 intermolecular recognition site; other site 479435011787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011788 DNA binding residues [nucleotide binding] 479435011789 dimerization interface [polypeptide binding]; other site 479435011790 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435011791 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479435011792 Carboxylesterase family; Region: COesterase; pfam00135 479435011793 substrate binding pocket [chemical binding]; other site 479435011794 catalytic triad [active] 479435011795 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 479435011796 Dehydroquinase class II; Region: DHquinase_II; pfam01220 479435011797 trimer interface [polypeptide binding]; other site 479435011798 active site 479435011799 dimer interface [polypeptide binding]; other site 479435011800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011801 Part of AAA domain; Region: AAA_19; pfam13245 479435011802 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435011803 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011804 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435011805 DNA binding residues [nucleotide binding] 479435011806 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 479435011807 active site 479435011808 dimer interface [polypeptide binding]; other site 479435011809 metal binding site [ion binding]; metal-binding site 479435011810 shikimate kinase; Reviewed; Region: aroK; PRK00131 479435011811 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 479435011812 magnesium binding site [ion binding]; other site 479435011813 putative shikimate binding site; other site 479435011814 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 479435011815 chorismate synthase; Validated; Region: PRK05382 479435011816 Tetramer interface [polypeptide binding]; other site 479435011817 active site 479435011818 FMN-binding site [chemical binding]; other site 479435011819 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 479435011820 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435011821 FAD binding domain; Region: FAD_binding_4; pfam01565 479435011822 Berberine and berberine like; Region: BBE; pfam08031 479435011823 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435011824 FAD binding domain; Region: FAD_binding_4; pfam01565 479435011825 Berberine and berberine like; Region: BBE; pfam08031 479435011826 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 479435011827 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 479435011828 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 479435011829 NAD(P) binding pocket [chemical binding]; other site 479435011830 YceG-like family; Region: YceG; pfam02618 479435011831 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 479435011832 dimerization interface [polypeptide binding]; other site 479435011833 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 479435011834 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 479435011835 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 479435011836 motif 1; other site 479435011837 active site 479435011838 motif 2; other site 479435011839 motif 3; other site 479435011840 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 479435011841 recombination factor protein RarA; Reviewed; Region: PRK13342 479435011842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435011843 Walker A motif; other site 479435011844 ATP binding site [chemical binding]; other site 479435011845 Walker B motif; other site 479435011846 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 479435011847 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435011848 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435011849 DNA binding residues [nucleotide binding] 479435011850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435011851 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435011852 putative substrate translocation pore; other site 479435011853 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 479435011854 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 479435011855 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435011856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435011857 Coenzyme A binding pocket [chemical binding]; other site 479435011858 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 479435011859 active site 479435011860 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 479435011861 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 479435011862 Predicted transcriptional regulators [Transcription]; Region: COG1725 479435011863 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435011864 DNA-binding site [nucleotide binding]; DNA binding site 479435011865 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435011866 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 479435011867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435011868 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435011869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435011870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435011871 S-adenosylmethionine binding site [chemical binding]; other site 479435011872 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 479435011873 catalytic residue [active] 479435011874 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 479435011875 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 479435011876 dimer interface [polypeptide binding]; other site 479435011877 anticodon binding site; other site 479435011878 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 479435011879 homodimer interface [polypeptide binding]; other site 479435011880 motif 1; other site 479435011881 active site 479435011882 motif 2; other site 479435011883 GAD domain; Region: GAD; pfam02938 479435011884 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435011885 active site 479435011886 motif 3; other site 479435011887 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 479435011888 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 479435011889 dimer interface [polypeptide binding]; other site 479435011890 motif 1; other site 479435011891 active site 479435011892 motif 2; other site 479435011893 motif 3; other site 479435011894 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 479435011895 anticodon binding site; other site 479435011896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435011897 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479435011898 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 479435011899 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479435011900 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435011901 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435011902 Coenzyme A binding pocket [chemical binding]; other site 479435011903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435011904 Phosphotransferase enzyme family; Region: APH; pfam01636 479435011905 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 479435011906 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435011907 Zn2+ binding site [ion binding]; other site 479435011908 Mg2+ binding site [ion binding]; other site 479435011909 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 479435011910 synthetase active site [active] 479435011911 NTP binding site [chemical binding]; other site 479435011912 metal binding site [ion binding]; metal-binding site 479435011913 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 479435011914 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 479435011915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435011916 active site 479435011917 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 479435011918 Protein export membrane protein; Region: SecD_SecF; pfam02355 479435011919 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 479435011920 Protein export membrane protein; Region: SecD_SecF; cl14618 479435011921 Preprotein translocase subunit; Region: YajC; pfam02699 479435011922 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 479435011923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435011924 Walker A motif; other site 479435011925 ATP binding site [chemical binding]; other site 479435011926 Walker B motif; other site 479435011927 arginine finger; other site 479435011928 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 479435011929 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 479435011930 RuvA N terminal domain; Region: RuvA_N; pfam01330 479435011931 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 479435011932 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 479435011933 active site 479435011934 putative DNA-binding cleft [nucleotide binding]; other site 479435011935 dimer interface [polypeptide binding]; other site 479435011936 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 479435011937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435011938 Coenzyme A binding pocket [chemical binding]; other site 479435011939 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435011940 CoenzymeA binding site [chemical binding]; other site 479435011941 subunit interaction site [polypeptide binding]; other site 479435011942 PHB binding site; other site 479435011943 hypothetical protein; Validated; Region: PRK00110 479435011944 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 479435011945 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 479435011946 predicted active site [active] 479435011947 catalytic triad [active] 479435011948 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 479435011949 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435011950 ATP binding site [chemical binding]; other site 479435011951 putative Mg++ binding site [ion binding]; other site 479435011952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435011953 nucleotide binding region [chemical binding]; other site 479435011954 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 479435011955 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 479435011956 YCII-related domain; Region: YCII; cl00999 479435011957 AAA ATPase domain; Region: AAA_16; pfam13191 479435011958 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435011959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435011960 DNA binding residues [nucleotide binding] 479435011961 dimerization interface [polypeptide binding]; other site 479435011962 CAAX protease self-immunity; Region: Abi; pfam02517 479435011963 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435011964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435011965 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435011966 FAD binding domain; Region: FAD_binding_4; pfam01565 479435011967 Berberine and berberine like; Region: BBE; pfam08031 479435011968 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435011969 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435011970 DNA binding residues [nucleotide binding] 479435011971 dimer interface [polypeptide binding]; other site 479435011972 TM1410 hypothetical-related protein; Region: DUF297; cl00997 479435011973 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 479435011974 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 479435011975 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 479435011976 active site 479435011977 multimer interface [polypeptide binding]; other site 479435011978 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435011979 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435011980 DNA-binding site [nucleotide binding]; DNA binding site 479435011981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435011982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435011983 homodimer interface [polypeptide binding]; other site 479435011984 catalytic residue [active] 479435011985 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 479435011986 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 479435011987 active site 479435011988 DNA binding site [nucleotide binding] 479435011989 catalytic site [active] 479435011990 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435011991 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435011992 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435011993 DNA binding residues [nucleotide binding] 479435011994 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435011995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435011996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435011997 dimer interface [polypeptide binding]; other site 479435011998 phosphorylation site [posttranslational modification] 479435011999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012000 ATP binding site [chemical binding]; other site 479435012001 Mg2+ binding site [ion binding]; other site 479435012002 G-X-G motif; other site 479435012003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435012004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435012005 active site 479435012006 phosphorylation site [posttranslational modification] 479435012007 intermolecular recognition site; other site 479435012008 dimerization interface [polypeptide binding]; other site 479435012009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435012010 DNA binding site [nucleotide binding] 479435012011 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 479435012012 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435012013 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 479435012014 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435012015 tetramer interface [polypeptide binding]; other site 479435012016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435012017 catalytic residue [active] 479435012018 Predicted integral membrane protein [Function unknown]; Region: COG5650 479435012019 Predicted integral membrane protein [Function unknown]; Region: COG5650 479435012020 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435012021 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 479435012022 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435012023 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435012024 active site 479435012025 ATP binding site [chemical binding]; other site 479435012026 substrate binding site [chemical binding]; other site 479435012027 activation loop (A-loop); other site 479435012028 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 479435012029 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435012030 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435012031 nucleotide binding site [chemical binding]; other site 479435012032 MMPL family; Region: MMPL; pfam03176 479435012033 MMPL family; Region: MMPL; pfam03176 479435012034 Anti-sigma-K factor rskA; Region: RskA; pfam10099 479435012035 RNA polymerase sigma factor; Provisional; Region: PRK12519 479435012036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435012038 DNA binding residues [nucleotide binding] 479435012039 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 479435012040 active site 479435012041 putative catalytic site [active] 479435012042 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 479435012043 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 479435012044 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 479435012045 putative hydrophobic ligand binding site [chemical binding]; other site 479435012046 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012047 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 479435012048 NAD(P) binding site [chemical binding]; other site 479435012049 active site 479435012050 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 479435012051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479435012052 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 479435012053 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 479435012054 active site 479435012055 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 479435012056 propionate/acetate kinase; Provisional; Region: PRK12379 479435012057 phosphate acetyltransferase; Reviewed; Region: PRK05632 479435012058 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 479435012059 Switch II region; other site 479435012060 G4 box; other site 479435012061 DRTGG domain; Region: DRTGG; pfam07085 479435012062 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 479435012063 PRC-barrel domain; Region: PRC; pfam05239 479435012064 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 479435012065 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435012066 anti sigma factor interaction site; other site 479435012067 regulatory phosphorylation site [posttranslational modification]; other site 479435012068 PAS domain; Region: PAS_9; pfam13426 479435012069 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435012070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435012071 dimer interface [polypeptide binding]; other site 479435012072 phosphorylation site [posttranslational modification] 479435012073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012074 ATP binding site [chemical binding]; other site 479435012075 Mg2+ binding site [ion binding]; other site 479435012076 G-X-G motif; other site 479435012077 Response regulator receiver domain; Region: Response_reg; pfam00072 479435012078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435012079 active site 479435012080 phosphorylation site [posttranslational modification] 479435012081 intermolecular recognition site; other site 479435012082 dimerization interface [polypeptide binding]; other site 479435012083 PAS domain S-box; Region: sensory_box; TIGR00229 479435012084 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 479435012085 putative active site [active] 479435012086 heme pocket [chemical binding]; other site 479435012087 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 479435012088 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435012089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435012090 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435012091 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435012092 dimer interface [polypeptide binding]; other site 479435012093 putative PBP binding regions; other site 479435012094 ABC-ATPase subunit interface; other site 479435012095 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435012096 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435012097 Walker A/P-loop; other site 479435012098 ATP binding site [chemical binding]; other site 479435012099 Q-loop/lid; other site 479435012100 ABC transporter signature motif; other site 479435012101 Walker B; other site 479435012102 D-loop; other site 479435012103 H-loop/switch region; other site 479435012104 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 479435012105 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435012106 intersubunit interface [polypeptide binding]; other site 479435012107 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435012108 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 479435012109 AAA ATPase domain; Region: AAA_16; pfam13191 479435012110 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435012112 DNA binding residues [nucleotide binding] 479435012113 dimerization interface [polypeptide binding]; other site 479435012114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435012116 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 479435012117 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435012118 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 479435012119 putative NAD(P) binding site [chemical binding]; other site 479435012120 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 479435012121 active site 479435012122 Mn binding site [ion binding]; other site 479435012123 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 479435012124 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012125 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435012126 DNA binding residues [nucleotide binding] 479435012127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435012128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012129 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 479435012130 NmrA-like family; Region: NmrA; pfam05368 479435012131 NADP binding site [chemical binding]; other site 479435012132 active site 479435012133 regulatory binding site [polypeptide binding]; other site 479435012134 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435012135 FAD binding domain; Region: FAD_binding_4; pfam01565 479435012136 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435012137 MarR family; Region: MarR_2; pfam12802 479435012138 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435012139 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435012140 putative NAD(P) binding site [chemical binding]; other site 479435012141 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435012143 active site 479435012144 phosphorylation site [posttranslational modification] 479435012145 intermolecular recognition site; other site 479435012146 dimerization interface [polypeptide binding]; other site 479435012147 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435012148 DNA binding residues [nucleotide binding] 479435012149 dimerization interface [polypeptide binding]; other site 479435012150 Histidine kinase; Region: HisKA_3; pfam07730 479435012151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012152 ATP binding site [chemical binding]; other site 479435012153 Mg2+ binding site [ion binding]; other site 479435012154 G-X-G motif; other site 479435012155 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435012156 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435012157 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 479435012158 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435012159 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435012160 Walker A/P-loop; other site 479435012161 ATP binding site [chemical binding]; other site 479435012162 Q-loop/lid; other site 479435012163 ABC transporter signature motif; other site 479435012164 Walker B; other site 479435012165 D-loop; other site 479435012166 H-loop/switch region; other site 479435012167 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435012168 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435012169 ABC-ATPase subunit interface; other site 479435012170 dimer interface [polypeptide binding]; other site 479435012171 putative PBP binding regions; other site 479435012172 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435012173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435012174 S-adenosylmethionine binding site [chemical binding]; other site 479435012175 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 479435012176 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 479435012177 intersubunit interface [polypeptide binding]; other site 479435012178 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435012179 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435012180 Walker A/P-loop; other site 479435012181 ATP binding site [chemical binding]; other site 479435012182 Q-loop/lid; other site 479435012183 ABC transporter signature motif; other site 479435012184 Walker B; other site 479435012185 D-loop; other site 479435012186 H-loop/switch region; other site 479435012187 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 479435012188 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435012190 active site 479435012191 phosphorylation site [posttranslational modification] 479435012192 intermolecular recognition site; other site 479435012193 dimerization interface [polypeptide binding]; other site 479435012194 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435012195 DNA binding residues [nucleotide binding] 479435012196 dimerization interface [polypeptide binding]; other site 479435012197 Histidine kinase; Region: HisKA_3; pfam07730 479435012198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012199 ATP binding site [chemical binding]; other site 479435012200 Mg2+ binding site [ion binding]; other site 479435012201 G-X-G motif; other site 479435012202 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435012203 conserved cys residue [active] 479435012204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435012205 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435012206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435012207 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 479435012208 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 479435012209 active site 479435012210 Bacterial Ig-like domain; Region: Big_5; pfam13205 479435012211 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 479435012212 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 479435012213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012214 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435012215 putative substrate translocation pore; other site 479435012216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012217 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435012218 YCII-related domain; Region: YCII; cl00999 479435012219 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435012220 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 479435012221 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 479435012222 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435012223 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435012224 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435012225 DNA-binding site [nucleotide binding]; DNA binding site 479435012226 FCD domain; Region: FCD; pfam07729 479435012227 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 479435012228 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435012229 active site pocket [active] 479435012230 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435012232 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435012233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012234 dimer interface [polypeptide binding]; other site 479435012235 conserved gate region; other site 479435012236 putative PBP binding loops; other site 479435012237 ABC-ATPase subunit interface; other site 479435012238 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012240 dimer interface [polypeptide binding]; other site 479435012241 conserved gate region; other site 479435012242 putative PBP binding loops; other site 479435012243 ABC-ATPase subunit interface; other site 479435012244 classical (c) SDRs; Region: SDR_c; cd05233 479435012245 NAD(P) binding site [chemical binding]; other site 479435012246 active site 479435012247 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 479435012248 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435012249 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435012250 inhibitor site; inhibition site 479435012251 active site 479435012252 dimer interface [polypeptide binding]; other site 479435012253 catalytic residue [active] 479435012254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 479435012255 active site 479435012256 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435012257 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479435012258 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435012259 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435012260 classical (c) SDRs; Region: SDR_c; cd05233 479435012261 NAD(P) binding site [chemical binding]; other site 479435012262 active site 479435012263 MarR family; Region: MarR; pfam01047 479435012264 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435012265 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435012266 DNA binding site [nucleotide binding] 479435012267 domain linker motif; other site 479435012268 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435012269 ligand binding site [chemical binding]; other site 479435012270 dimerization interface [polypeptide binding]; other site 479435012271 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435012272 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 479435012273 active site 479435012274 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012275 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435012276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012277 dimer interface [polypeptide binding]; other site 479435012278 conserved gate region; other site 479435012279 putative PBP binding loops; other site 479435012280 ABC-ATPase subunit interface; other site 479435012281 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012283 dimer interface [polypeptide binding]; other site 479435012284 conserved gate region; other site 479435012285 putative PBP binding loops; other site 479435012286 ABC-ATPase subunit interface; other site 479435012287 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 479435012288 active site 479435012289 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435012290 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435012291 Dehydratase family; Region: ILVD_EDD; cl00340 479435012292 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 479435012293 classical (c) SDRs; Region: SDR_c; cd05233 479435012294 NAD(P) binding site [chemical binding]; other site 479435012295 active site 479435012296 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435012297 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435012298 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435012299 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 479435012300 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu_like; cd11331 479435012301 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435012302 active site 479435012303 catalytic site [active] 479435012304 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435012305 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435012306 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435012307 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435012308 dimerization interface [polypeptide binding]; other site 479435012309 putative DNA binding site [nucleotide binding]; other site 479435012310 putative Zn2+ binding site [ion binding]; other site 479435012311 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435012312 active site 479435012313 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435012314 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435012315 Uncharacterized conserved protein [Function unknown]; Region: COG4278 479435012316 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435012317 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 479435012318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435012319 active site 479435012320 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435012321 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435012322 active site 479435012323 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435012324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012325 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435012326 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012327 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435012328 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435012329 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435012330 Walker A/P-loop; other site 479435012331 ATP binding site [chemical binding]; other site 479435012332 Q-loop/lid; other site 479435012333 ABC transporter signature motif; other site 479435012334 Walker B; other site 479435012335 D-loop; other site 479435012336 H-loop/switch region; other site 479435012337 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 479435012338 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435012339 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 479435012340 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 479435012341 CoA-transferase family III; Region: CoA_transf_3; pfam02515 479435012342 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 479435012343 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435012344 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479435012345 substrate binding site [chemical binding]; other site 479435012346 ATP binding site [chemical binding]; other site 479435012347 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 479435012348 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 479435012349 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012350 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435012351 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012352 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012353 dimer interface [polypeptide binding]; other site 479435012354 conserved gate region; other site 479435012355 putative PBP binding loops; other site 479435012356 ABC-ATPase subunit interface; other site 479435012357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012358 dimer interface [polypeptide binding]; other site 479435012359 conserved gate region; other site 479435012360 putative PBP binding loops; other site 479435012361 ABC-ATPase subunit interface; other site 479435012362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435012363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435012364 DNA binding site [nucleotide binding] 479435012365 domain linker motif; other site 479435012366 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435012367 ligand binding site [chemical binding]; other site 479435012368 dimerization interface [polypeptide binding]; other site 479435012369 Ion channel; Region: Ion_trans_2; pfam07885 479435012370 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 479435012371 TrkA-N domain; Region: TrkA_N; pfam02254 479435012372 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 479435012373 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435012374 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435012375 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435012376 active site 479435012377 catalytic site [active] 479435012378 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 479435012379 putative active site [active] 479435012380 catalytic site [active] 479435012381 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435012382 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 479435012383 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 479435012384 phosphoglucomutase; Validated; Region: PRK07564 479435012385 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 479435012386 active site 479435012387 substrate binding site [chemical binding]; other site 479435012388 metal binding site [ion binding]; metal-binding site 479435012389 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 479435012390 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435012391 S-adenosylmethionine binding site [chemical binding]; other site 479435012392 Protein of unknown function (DUF419); Region: DUF419; pfam04237 479435012393 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 479435012394 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435012396 DNA binding residues [nucleotide binding] 479435012397 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435012398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012399 NAD(P) binding site [chemical binding]; other site 479435012400 active site 479435012401 Uncharacterized conserved protein [Function unknown]; Region: COG2353 479435012402 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 479435012403 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 479435012404 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435012405 active site 479435012406 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 479435012407 active site 479435012408 catalytic site [active] 479435012409 substrate binding site [chemical binding]; other site 479435012410 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 479435012411 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 479435012412 active site 479435012413 metal binding site [ion binding]; metal-binding site 479435012414 homotetramer interface [polypeptide binding]; other site 479435012415 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435012416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012417 NAD(P) binding site [chemical binding]; other site 479435012418 active site 479435012419 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435012420 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 479435012421 putative dimer interface [polypeptide binding]; other site 479435012422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435012423 ligand binding site [chemical binding]; other site 479435012424 Zn binding site [ion binding]; other site 479435012425 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479435012426 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 479435012427 Family description; Region: UvrD_C_2; pfam13538 479435012428 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479435012429 AAA domain; Region: AAA_17; pfam13207 479435012430 AAA domain; Region: AAA_18; pfam13238 479435012431 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435012432 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435012433 Hemerythrin-like domain; Region: Hr-like; cd12108 479435012434 Fe binding site [ion binding]; other site 479435012435 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435012436 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 479435012437 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435012438 DNA binding site [nucleotide binding] 479435012439 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435012440 Predicted ATPase [General function prediction only]; Region: COG3903 479435012441 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435012442 Predicted flavoprotein [General function prediction only]; Region: COG0431 479435012443 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435012444 RibD C-terminal domain; Region: RibD_C; cl17279 479435012445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435012446 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435012447 S-adenosylmethionine binding site [chemical binding]; other site 479435012448 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435012449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435012450 DNA-binding site [nucleotide binding]; DNA binding site 479435012451 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 479435012452 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 479435012453 NAD binding site [chemical binding]; other site 479435012454 ligand binding site [chemical binding]; other site 479435012455 catalytic site [active] 479435012456 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012458 dimer interface [polypeptide binding]; other site 479435012459 conserved gate region; other site 479435012460 putative PBP binding loops; other site 479435012461 ABC-ATPase subunit interface; other site 479435012462 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435012463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012464 dimer interface [polypeptide binding]; other site 479435012465 putative PBP binding loops; other site 479435012466 ABC-ATPase subunit interface; other site 479435012467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435012469 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 479435012470 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435012471 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435012472 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435012473 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 479435012474 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 479435012475 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 479435012476 Protein of unknown function (DUF805); Region: DUF805; pfam05656 479435012477 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 479435012478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435012479 HTH domain; Region: HTH_11; pfam08279 479435012480 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435012481 WYL domain; Region: WYL; pfam13280 479435012482 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435012483 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435012484 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 479435012485 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 479435012486 putative NAD(P) binding site [chemical binding]; other site 479435012487 active site 479435012488 HTH domain; Region: HTH_11; pfam08279 479435012489 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435012490 WYL domain; Region: WYL; pfam13280 479435012491 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435012492 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435012493 active site 479435012494 catalytic tetrad [active] 479435012495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435012496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435012497 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 479435012498 putative dimerization interface [polypeptide binding]; other site 479435012499 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435012500 active site 479435012501 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 479435012502 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435012503 sequence-specific DNA binding site [nucleotide binding]; other site 479435012504 salt bridge; other site 479435012505 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 479435012506 amidase; Provisional; Region: PRK07042 479435012507 Amidase; Region: Amidase; cl11426 479435012508 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435012509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435012510 classical (c) SDRs; Region: SDR_c; cd05233 479435012511 NAD(P) binding site [chemical binding]; other site 479435012512 active site 479435012513 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435012514 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435012515 NAD(P) binding site [chemical binding]; other site 479435012516 catalytic residues [active] 479435012517 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 479435012518 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435012519 Walker A/P-loop; other site 479435012520 ATP binding site [chemical binding]; other site 479435012521 Q-loop/lid; other site 479435012522 ABC transporter signature motif; other site 479435012523 Walker B; other site 479435012524 D-loop; other site 479435012525 H-loop/switch region; other site 479435012526 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435012527 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435012528 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435012529 Walker A/P-loop; other site 479435012530 ATP binding site [chemical binding]; other site 479435012531 Q-loop/lid; other site 479435012532 ABC transporter signature motif; other site 479435012533 Walker B; other site 479435012534 D-loop; other site 479435012535 H-loop/switch region; other site 479435012536 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435012537 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435012538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012539 dimer interface [polypeptide binding]; other site 479435012540 conserved gate region; other site 479435012541 putative PBP binding loops; other site 479435012542 ABC-ATPase subunit interface; other site 479435012543 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435012544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012545 dimer interface [polypeptide binding]; other site 479435012546 conserved gate region; other site 479435012547 putative PBP binding loops; other site 479435012548 ABC-ATPase subunit interface; other site 479435012549 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 479435012550 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435012551 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479435012552 RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably...; Region: RING; cd00162 479435012553 Zinc finger, C3HC4 type (RING finger); Region: zf-C3HC4_2; pfam13923 479435012554 cross-brace motif; other site 479435012555 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 479435012556 putative metal binding site [ion binding]; other site 479435012557 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435012558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435012559 putative substrate translocation pore; other site 479435012560 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 479435012561 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 479435012562 metal binding site [ion binding]; metal-binding site 479435012563 active site 479435012564 I-site; other site 479435012565 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 479435012566 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435012567 putative NAD(P) binding site [chemical binding]; other site 479435012568 SNF2 Helicase protein; Region: DUF3670; pfam12419 479435012569 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 479435012570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435012571 ATP binding site [chemical binding]; other site 479435012572 putative Mg++ binding site [ion binding]; other site 479435012573 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 479435012574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435012575 nucleotide binding region [chemical binding]; other site 479435012576 ATP-binding site [chemical binding]; other site 479435012577 Uncharacterized conserved protein [Function unknown]; Region: COG4279 479435012578 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 479435012579 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479435012580 active site 479435012581 catalytic triad [active] 479435012582 oxyanion hole [active] 479435012583 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435012584 putative metal binding site [ion binding]; other site 479435012585 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435012586 putative metal binding site [ion binding]; other site 479435012587 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435012588 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435012589 putative metal binding site [ion binding]; other site 479435012590 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435012591 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435012592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012593 dimer interface [polypeptide binding]; other site 479435012594 conserved gate region; other site 479435012595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479435012596 ABC-ATPase subunit interface; other site 479435012597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012598 putative PBP binding loops; other site 479435012599 dimer interface [polypeptide binding]; other site 479435012600 ABC-ATPase subunit interface; other site 479435012601 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435012602 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435012603 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 479435012604 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435012605 active site 479435012606 catalytic site [active] 479435012607 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 479435012608 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435012609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435012610 DNA binding site [nucleotide binding] 479435012611 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435012612 ligand binding site [chemical binding]; other site 479435012613 dimerization interface [polypeptide binding]; other site 479435012614 KTSC domain; Region: KTSC; pfam13619 479435012615 hypothetical protein; Provisional; Region: PRK04140 479435012616 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435012617 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435012618 active site 479435012619 catalytic tetrad [active] 479435012620 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435012621 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479435012622 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435012623 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479435012624 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435012625 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 479435012626 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 479435012627 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 479435012628 active site 479435012629 dimer interface [polypeptide binding]; other site 479435012630 effector binding site; other site 479435012631 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 479435012632 TSCPD domain; Region: TSCPD; pfam12637 479435012633 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 479435012634 ATP cone domain; Region: ATP-cone; pfam03477 479435012635 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 479435012636 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435012637 active site 479435012638 catalytic site [active] 479435012639 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 479435012640 active site 479435012641 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479435012642 LexA repressor; Validated; Region: PRK00215 479435012643 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435012644 putative DNA binding site [nucleotide binding]; other site 479435012645 putative Zn2+ binding site [ion binding]; other site 479435012646 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 479435012647 Catalytic site [active] 479435012648 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 479435012649 catalytic residues [active] 479435012650 dimer interface [polypeptide binding]; other site 479435012651 thiamine pyrophosphate protein; Provisional; Region: PRK08273 479435012652 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 479435012653 PYR/PP interface [polypeptide binding]; other site 479435012654 dimer interface [polypeptide binding]; other site 479435012655 tetramer interface [polypeptide binding]; other site 479435012656 TPP binding site [chemical binding]; other site 479435012657 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435012658 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 479435012659 TPP-binding site [chemical binding]; other site 479435012660 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 479435012661 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 479435012662 active site 479435012663 DNA binding site [nucleotide binding] 479435012664 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 479435012665 DNA binding site [nucleotide binding] 479435012666 DEAD/DEAH box helicase; Region: DEAD; pfam00270 479435012667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435012668 putative Mg++ binding site [ion binding]; other site 479435012669 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 479435012670 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 479435012671 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 479435012672 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 479435012673 Protein export membrane protein; Region: SecD_SecF; cl14618 479435012674 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 479435012675 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 479435012676 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 479435012677 calcium binding site 2 [ion binding]; other site 479435012678 active site 479435012679 catalytic triad [active] 479435012680 calcium binding site 1 [ion binding]; other site 479435012681 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435012683 active site 479435012684 phosphorylation site [posttranslational modification] 479435012685 intermolecular recognition site; other site 479435012686 dimerization interface [polypeptide binding]; other site 479435012687 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435012688 DNA binding residues [nucleotide binding] 479435012689 dimerization interface [polypeptide binding]; other site 479435012690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435012691 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435012692 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435012693 GTPases [General function prediction only]; Region: HflX; COG2262 479435012694 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 479435012695 HflX GTPase family; Region: HflX; cd01878 479435012696 G1 box; other site 479435012697 GTP/Mg2+ binding site [chemical binding]; other site 479435012698 Switch I region; other site 479435012699 G2 box; other site 479435012700 G3 box; other site 479435012701 Switch II region; other site 479435012702 G4 box; other site 479435012703 G5 box; other site 479435012704 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 479435012705 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 479435012706 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 479435012707 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 479435012708 Peptidase family M1; Region: Peptidase_M1; pfam01433 479435012709 Zn binding site [ion binding]; other site 479435012710 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435012711 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012712 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435012713 DNA binding residues [nucleotide binding] 479435012714 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 479435012715 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479435012716 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435012717 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435012719 DNA binding residues [nucleotide binding] 479435012720 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 479435012721 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 479435012722 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 479435012723 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 479435012724 nudix motif; other site 479435012725 Phosphotransferase enzyme family; Region: APH; pfam01636 479435012726 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435012727 active site 479435012728 substrate binding site [chemical binding]; other site 479435012729 ATP binding site [chemical binding]; other site 479435012730 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 479435012731 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 479435012732 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435012733 FeS/SAM binding site; other site 479435012734 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435012735 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435012736 Amidohydrolase; Region: Amidohydro_4; pfam13147 479435012737 active site 479435012738 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435012739 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435012740 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 479435012741 Walker A/P-loop; other site 479435012742 ATP binding site [chemical binding]; other site 479435012743 Q-loop/lid; other site 479435012744 ABC transporter signature motif; other site 479435012745 Walker B; other site 479435012746 D-loop; other site 479435012747 H-loop/switch region; other site 479435012748 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435012749 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435012750 substrate binding pocket [chemical binding]; other site 479435012751 membrane-bound complex binding site; other site 479435012752 hinge residues; other site 479435012753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012754 dimer interface [polypeptide binding]; other site 479435012755 conserved gate region; other site 479435012756 putative PBP binding loops; other site 479435012757 ABC-ATPase subunit interface; other site 479435012758 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435012759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435012760 dimer interface [polypeptide binding]; other site 479435012761 conserved gate region; other site 479435012762 putative PBP binding loops; other site 479435012763 ABC-ATPase subunit interface; other site 479435012764 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 479435012765 Phosphotransferase enzyme family; Region: APH; pfam01636 479435012766 putative active site [active] 479435012767 putative substrate binding site [chemical binding]; other site 479435012768 ATP binding site [chemical binding]; other site 479435012769 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479435012770 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 479435012771 inhibitor-cofactor binding pocket; inhibition site 479435012772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435012773 catalytic residue [active] 479435012774 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 479435012775 pyridoxamine kinase; Validated; Region: PRK05756 479435012776 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 479435012777 dimer interface [polypeptide binding]; other site 479435012778 pyridoxal binding site [chemical binding]; other site 479435012779 ATP binding site [chemical binding]; other site 479435012780 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 479435012781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435012782 FeS/SAM binding site; other site 479435012783 Rdx family; Region: Rdx; cl01407 479435012784 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 479435012785 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435012786 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435012787 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435012788 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 479435012789 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 479435012790 ribosome recycling factor; Reviewed; Region: frr; PRK00083 479435012791 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 479435012792 hinge region; other site 479435012793 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 479435012794 putative nucleotide binding site [chemical binding]; other site 479435012795 uridine monophosphate binding site [chemical binding]; other site 479435012796 homohexameric interface [polypeptide binding]; other site 479435012797 elongation factor Ts; Provisional; Region: tsf; PRK09377 479435012798 UBA/TS-N domain; Region: UBA; pfam00627 479435012799 Elongation factor TS; Region: EF_TS; pfam00889 479435012800 Elongation factor TS; Region: EF_TS; pfam00889 479435012801 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 479435012802 rRNA interaction site [nucleotide binding]; other site 479435012803 S8 interaction site; other site 479435012804 putative laminin-1 binding site; other site 479435012805 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435012806 Predicted transcriptional regulator [Transcription]; Region: COG1959 479435012807 Transcriptional regulator; Region: Rrf2; pfam02082 479435012808 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 479435012809 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435012810 active site 479435012811 DNA binding site [nucleotide binding] 479435012812 Int/Topo IB signature motif; other site 479435012813 amino acid transporter; Region: 2A0306; TIGR00909 479435012814 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 479435012815 hypothetical protein; Reviewed; Region: PRK12497 479435012816 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 479435012817 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 479435012818 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 479435012819 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 479435012820 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 479435012821 DNA protecting protein DprA; Region: dprA; TIGR00732 479435012822 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 479435012823 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 479435012824 RNA/DNA hybrid binding site [nucleotide binding]; other site 479435012825 active site 479435012826 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 479435012827 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479435012828 Catalytic site [active] 479435012829 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 479435012830 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 479435012831 Catalytic site [active] 479435012832 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 479435012833 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 479435012834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435012835 Coenzyme A binding pocket [chemical binding]; other site 479435012836 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 479435012837 RimM N-terminal domain; Region: RimM; pfam01782 479435012838 PRC-barrel domain; Region: PRC; pfam05239 479435012839 hypothetical protein; Provisional; Region: PRK02821 479435012840 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 479435012841 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 479435012842 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 479435012843 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 479435012844 NAD binding site [chemical binding]; other site 479435012845 sugar binding site [chemical binding]; other site 479435012846 divalent metal binding site [ion binding]; other site 479435012847 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435012848 dimer interface [polypeptide binding]; other site 479435012849 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435012850 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 479435012851 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479435012852 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479435012853 substrate binding site [chemical binding]; other site 479435012854 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435012855 ATP binding site [chemical binding]; other site 479435012856 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 479435012857 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435012858 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435012859 Trypsin; Region: Trypsin; pfam00089 479435012860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435012861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435012862 active site 479435012863 phosphorylation site [posttranslational modification] 479435012864 intermolecular recognition site; other site 479435012865 dimerization interface [polypeptide binding]; other site 479435012866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435012867 DNA binding residues [nucleotide binding] 479435012868 dimerization interface [polypeptide binding]; other site 479435012869 Putative sensor; Region: Sensor; pfam13796 479435012870 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435012871 Histidine kinase; Region: HisKA_3; pfam07730 479435012872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435012873 ATP binding site [chemical binding]; other site 479435012874 Mg2+ binding site [ion binding]; other site 479435012875 G-X-G motif; other site 479435012876 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 479435012877 amidase catalytic site [active] 479435012878 Zn binding residues [ion binding]; other site 479435012879 substrate binding site [chemical binding]; other site 479435012880 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435012881 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435012882 active site 479435012883 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479435012884 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435012885 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 479435012886 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479435012887 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435012888 signal recognition particle protein; Provisional; Region: PRK10867 479435012889 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 479435012890 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 479435012891 P loop; other site 479435012892 GTP binding site [chemical binding]; other site 479435012893 Signal peptide binding domain; Region: SRP_SPB; pfam02978 479435012894 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 479435012895 active site 479435012896 Mn binding site [ion binding]; other site 479435012897 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 479435012898 PII uridylyl-transferase; Provisional; Region: PRK03381 479435012899 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 479435012900 metal binding triad; other site 479435012901 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 479435012902 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 479435012903 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 479435012904 Nitrogen regulatory protein P-II; Region: P-II; smart00938 479435012905 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 479435012906 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435012907 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435012908 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435012909 DNA binding residues [nucleotide binding] 479435012910 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 479435012911 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435012912 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 479435012913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435012914 non-specific DNA binding site [nucleotide binding]; other site 479435012915 salt bridge; other site 479435012916 sequence-specific DNA binding site [nucleotide binding]; other site 479435012917 Cupin domain; Region: Cupin_2; pfam07883 479435012918 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 479435012919 active site 479435012920 homotetramer interface [polypeptide binding]; other site 479435012921 homodimer interface [polypeptide binding]; other site 479435012922 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435012923 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435012924 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435012925 DNA binding residues [nucleotide binding] 479435012926 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 479435012927 apolar tunnel; other site 479435012928 heme binding site [chemical binding]; other site 479435012929 dimerization interface [polypeptide binding]; other site 479435012930 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 479435012931 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 479435012932 heme-binding site [chemical binding]; other site 479435012933 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 479435012934 FAD binding pocket [chemical binding]; other site 479435012935 FAD binding motif [chemical binding]; other site 479435012936 phosphate binding motif [ion binding]; other site 479435012937 beta-alpha-beta structure motif; other site 479435012938 NAD binding pocket [chemical binding]; other site 479435012939 DivIVA domain; Region: DivI1A_domain; TIGR03544 479435012940 DivIVA protein; Region: DivIVA; pfam05103 479435012941 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 479435012942 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 479435012943 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435012944 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 479435012945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435012946 Walker A/P-loop; other site 479435012947 ATP binding site [chemical binding]; other site 479435012948 Q-loop/lid; other site 479435012949 ABC transporter signature motif; other site 479435012950 Walker B; other site 479435012951 D-loop; other site 479435012952 H-loop/switch region; other site 479435012953 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 479435012954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435012955 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 479435012956 Walker A/P-loop; other site 479435012957 ATP binding site [chemical binding]; other site 479435012958 Q-loop/lid; other site 479435012959 ABC transporter signature motif; other site 479435012960 Walker B; other site 479435012961 D-loop; other site 479435012962 H-loop/switch region; other site 479435012963 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 479435012964 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 479435012965 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 479435012966 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 479435012967 Penicillinase repressor; Region: Pencillinase_R; cl17580 479435012968 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 479435012969 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435012970 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 479435012971 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435012972 catalytic residue [active] 479435012973 AAA domain; Region: AAA_23; pfam13476 479435012974 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 479435012975 Walker A/P-loop; other site 479435012976 ATP binding site [chemical binding]; other site 479435012977 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 479435012978 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 479435012979 ABC transporter signature motif; other site 479435012980 Walker B; other site 479435012981 D-loop; other site 479435012982 H-loop/switch region; other site 479435012983 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 479435012984 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 479435012985 DNA binding site [nucleotide binding] 479435012986 catalytic residue [active] 479435012987 H2TH interface [polypeptide binding]; other site 479435012988 putative catalytic residues [active] 479435012989 turnover-facilitating residue; other site 479435012990 intercalation triad [nucleotide binding]; other site 479435012991 8OG recognition residue [nucleotide binding]; other site 479435012992 putative reading head residues; other site 479435012993 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 479435012994 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 479435012995 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 479435012996 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 479435012997 dimerization interface [polypeptide binding]; other site 479435012998 active site 479435012999 metal binding site [ion binding]; metal-binding site 479435013000 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 479435013001 dsRNA binding site [nucleotide binding]; other site 479435013002 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 479435013003 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 479435013004 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 479435013005 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 479435013006 active site 479435013007 (T/H)XGH motif; other site 479435013008 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 479435013009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013010 S-adenosylmethionine binding site [chemical binding]; other site 479435013011 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 479435013012 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 479435013013 generic binding surface II; other site 479435013014 ssDNA binding site; other site 479435013015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435013016 ATP binding site [chemical binding]; other site 479435013017 putative Mg++ binding site [ion binding]; other site 479435013018 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435013019 nucleotide binding region [chemical binding]; other site 479435013020 ATP-binding site [chemical binding]; other site 479435013021 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 479435013022 DAK2 domain; Region: Dak2; pfam02734 479435013023 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435013024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 479435013025 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 479435013026 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 479435013027 Predicted kinase [General function prediction only]; Region: COG0645 479435013028 AAA domain; Region: AAA_17; pfam13207 479435013029 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 479435013030 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435013031 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435013032 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435013033 active site 479435013034 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435013035 catalytic tetrad [active] 479435013036 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435013037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013038 dimer interface [polypeptide binding]; other site 479435013039 conserved gate region; other site 479435013040 putative PBP binding loops; other site 479435013041 ABC-ATPase subunit interface; other site 479435013042 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435013043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013044 dimer interface [polypeptide binding]; other site 479435013045 conserved gate region; other site 479435013046 putative PBP binding loops; other site 479435013047 ABC-ATPase subunit interface; other site 479435013048 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013049 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435013050 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479435013051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435013052 motif II; other site 479435013053 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435013054 putative hydrolase; Provisional; Region: PRK11460 479435013055 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 479435013056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435013057 active site 479435013058 motif I; other site 479435013059 motif II; other site 479435013060 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435013061 DinB superfamily; Region: DinB_2; pfam12867 479435013062 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 479435013063 dimer interface [polypeptide binding]; other site 479435013064 substrate binding site [chemical binding]; other site 479435013065 ATP binding site [chemical binding]; other site 479435013066 thiamine monophosphate kinase; Provisional; Region: PRK05731 479435013067 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 479435013068 ATP binding site [chemical binding]; other site 479435013069 dimerization interface [polypeptide binding]; other site 479435013070 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435013071 AsnC family; Region: AsnC_trans_reg; pfam01037 479435013072 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 479435013073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435013074 Histidine kinase; Region: HisKA_3; pfam07730 479435013075 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435013076 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435013077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435013078 active site 479435013079 phosphorylation site [posttranslational modification] 479435013080 intermolecular recognition site; other site 479435013081 dimerization interface [polypeptide binding]; other site 479435013082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435013083 DNA binding residues [nucleotide binding] 479435013084 dimerization interface [polypeptide binding]; other site 479435013085 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435013086 YCII-related domain; Region: YCII; cl00999 479435013087 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435013088 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013089 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435013090 DNA binding residues [nucleotide binding] 479435013091 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435013093 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435013094 putative substrate translocation pore; other site 479435013095 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 479435013096 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435013097 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 479435013098 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 479435013099 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 479435013100 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435013101 Cytochrome P450; Region: p450; cl12078 479435013102 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435013103 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013104 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 479435013105 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435013106 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435013107 catalytic residue [active] 479435013108 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435013109 active site 479435013110 ATP binding site [chemical binding]; other site 479435013111 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435013112 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 479435013113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479435013114 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435013115 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 479435013116 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435013117 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435013118 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435013119 ROK family; Region: ROK; pfam00480 479435013120 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 479435013121 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 479435013122 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 479435013123 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 479435013124 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435013125 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 479435013126 putative acyl-acceptor binding pocket; other site 479435013127 Guanylyl transferase CofC like; Region: CofC; cl17472 479435013128 Guanylyl transferase CofC like; Region: CofC; cl17472 479435013129 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 479435013130 IHF - DNA interface [nucleotide binding]; other site 479435013131 IHF dimer interface [polypeptide binding]; other site 479435013132 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479435013133 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 479435013134 oligomer interface [polypeptide binding]; other site 479435013135 metal binding site [ion binding]; metal-binding site 479435013136 metal binding site [ion binding]; metal-binding site 479435013137 putative Cl binding site [ion binding]; other site 479435013138 basic sphincter; other site 479435013139 hydrophobic gate; other site 479435013140 periplasmic entrance; other site 479435013141 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 479435013142 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 479435013143 substrate binding site [chemical binding]; other site 479435013144 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 479435013145 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 479435013146 substrate binding site [chemical binding]; other site 479435013147 ligand binding site [chemical binding]; other site 479435013148 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479435013149 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435013150 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435013151 CAAX protease self-immunity; Region: Abi; pfam02517 479435013152 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 479435013153 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 479435013154 HIGH motif; other site 479435013155 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 479435013156 active site 479435013157 KMSKS motif; other site 479435013158 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 479435013159 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479435013160 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479435013161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435013162 Coenzyme A binding pocket [chemical binding]; other site 479435013163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013164 S-adenosylmethionine binding site [chemical binding]; other site 479435013165 DinB superfamily; Region: DinB_2; pfam12867 479435013166 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 479435013167 Class I ribonucleotide reductase; Region: RNR_I; cd01679 479435013168 active site 479435013169 dimer interface [polypeptide binding]; other site 479435013170 catalytic residues [active] 479435013171 effector binding site; other site 479435013172 R2 peptide binding site; other site 479435013173 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 479435013174 dimer interface [polypeptide binding]; other site 479435013175 putative radical transfer pathway; other site 479435013176 diiron center [ion binding]; other site 479435013177 tyrosyl radical; other site 479435013178 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435013179 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 479435013180 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435013181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013182 dimer interface [polypeptide binding]; other site 479435013183 conserved gate region; other site 479435013184 ABC-ATPase subunit interface; other site 479435013185 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 479435013186 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013187 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435013188 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435013189 Alcohol dehydrogenase GroES-like domain; Region: ADH_N; pfam08240 479435013190 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 479435013191 putative NAD(P) binding site [chemical binding]; other site 479435013192 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435013193 alpha-glucosidase; Provisional; Region: PRK10137 479435013194 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 479435013195 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 479435013196 active site 479435013197 catalytic residues [active] 479435013198 metal binding site [ion binding]; metal-binding site 479435013199 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 479435013200 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 479435013201 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 479435013202 homodimer interface [polypeptide binding]; other site 479435013203 substrate-cofactor binding pocket; other site 479435013204 catalytic residue [active] 479435013205 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 479435013206 Methyltransferase domain; Region: Methyltransf_24; pfam13578 479435013207 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 479435013208 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 479435013209 ligand binding site [chemical binding]; other site 479435013210 NAD binding site [chemical binding]; other site 479435013211 dimerization interface [polypeptide binding]; other site 479435013212 catalytic site [active] 479435013213 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 479435013214 putative L-serine binding site [chemical binding]; other site 479435013215 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479435013216 ketol-acid reductoisomerase; Provisional; Region: PRK05479 479435013217 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 479435013218 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 479435013219 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 479435013220 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 479435013221 putative valine binding site [chemical binding]; other site 479435013222 dimer interface [polypeptide binding]; other site 479435013223 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 479435013224 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 479435013225 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 479435013226 PYR/PP interface [polypeptide binding]; other site 479435013227 dimer interface [polypeptide binding]; other site 479435013228 TPP binding site [chemical binding]; other site 479435013229 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 479435013230 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 479435013231 TPP-binding site [chemical binding]; other site 479435013232 dimer interface [polypeptide binding]; other site 479435013233 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 479435013234 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 479435013235 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) [Nucleotide transport and metabolism]; Region: PurH; COG0138 479435013236 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 479435013237 MoaE interaction surface [polypeptide binding]; other site 479435013238 MoeB interaction surface [polypeptide binding]; other site 479435013239 thiocarboxylated glycine; other site 479435013240 BNR repeat-like domain; Region: BNR_3; pfam13859 479435013241 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_7; cd12166 479435013242 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 479435013243 putative ligand binding site [chemical binding]; other site 479435013244 putative NAD binding site [chemical binding]; other site 479435013245 catalytic site [active] 479435013246 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435013247 TIGR03086 family protein; Region: TIGR03086 479435013248 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435013249 FAD binding domain; Region: FAD_binding_4; pfam01565 479435013250 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 479435013251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013252 S-adenosylmethionine binding site [chemical binding]; other site 479435013253 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 479435013254 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 479435013255 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 479435013256 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 479435013257 GatB domain; Region: GatB_Yqey; smart00845 479435013258 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 479435013259 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 479435013260 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 479435013261 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435013262 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 479435013263 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 479435013264 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 479435013265 nucleotide binding pocket [chemical binding]; other site 479435013266 K-X-D-G motif; other site 479435013267 catalytic site [active] 479435013268 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 479435013269 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 479435013270 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 479435013271 Dimer interface [polypeptide binding]; other site 479435013272 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 479435013273 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 479435013274 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 479435013275 Ligand Binding Site [chemical binding]; other site 479435013276 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 479435013277 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 479435013278 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435013279 catalytic residue [active] 479435013280 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435013281 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435013282 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435013283 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 479435013284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435013285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013286 dimer interface [polypeptide binding]; other site 479435013287 conserved gate region; other site 479435013288 ABC-ATPase subunit interface; other site 479435013289 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 479435013290 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435013291 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435013292 Walker A/P-loop; other site 479435013293 ATP binding site [chemical binding]; other site 479435013294 Q-loop/lid; other site 479435013295 ABC transporter signature motif; other site 479435013296 Walker B; other site 479435013297 D-loop; other site 479435013298 H-loop/switch region; other site 479435013299 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435013300 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435013301 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435013302 Walker A/P-loop; other site 479435013303 ATP binding site [chemical binding]; other site 479435013304 Q-loop/lid; other site 479435013305 ABC transporter signature motif; other site 479435013306 Walker B; other site 479435013307 D-loop; other site 479435013308 H-loop/switch region; other site 479435013309 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435013310 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479435013311 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435013312 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435013313 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 479435013314 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435013315 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435013316 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435013317 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 479435013318 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 479435013319 metal binding site [ion binding]; metal-binding site 479435013320 dimer interface [polypeptide binding]; other site 479435013321 Uncharacterized conserved protein [Function unknown]; Region: COG3375 479435013322 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 479435013323 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 479435013324 active site 479435013325 octamer interface [polypeptide binding]; other site 479435013326 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479435013327 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 479435013328 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 479435013329 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 479435013330 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 479435013331 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 479435013332 Ligand binding site [chemical binding]; other site 479435013333 Electron transfer flavoprotein domain; Region: ETF; pfam01012 479435013334 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435013335 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013336 S-adenosylmethionine binding site [chemical binding]; other site 479435013337 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 479435013338 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 479435013339 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 479435013340 trimer interface [polypeptide binding]; other site 479435013341 active site 479435013342 substrate binding site [chemical binding]; other site 479435013343 CoA binding site [chemical binding]; other site 479435013344 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435013345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013346 S-adenosylmethionine binding site [chemical binding]; other site 479435013347 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435013348 enoyl-CoA hydratase; Provisional; Region: PRK05862 479435013349 substrate binding site [chemical binding]; other site 479435013350 oxyanion hole (OAH) forming residues; other site 479435013351 trimer interface [polypeptide binding]; other site 479435013352 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435013353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435013354 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435013355 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435013356 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435013357 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 479435013358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435013359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013360 dimer interface [polypeptide binding]; other site 479435013361 conserved gate region; other site 479435013362 putative PBP binding loops; other site 479435013363 ABC-ATPase subunit interface; other site 479435013364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013365 dimer interface [polypeptide binding]; other site 479435013366 conserved gate region; other site 479435013367 putative PBP binding loops; other site 479435013368 ABC-ATPase subunit interface; other site 479435013369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013370 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435013371 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 479435013372 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 479435013373 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 479435013374 active site 479435013375 catalytic site [active] 479435013376 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 479435013377 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435013378 DNA binding residues [nucleotide binding] 479435013379 drug binding residues [chemical binding]; other site 479435013380 dimer interface [polypeptide binding]; other site 479435013381 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 479435013382 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 479435013383 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 479435013384 putative homodimer interface [polypeptide binding]; other site 479435013385 putative active site pocket [active] 479435013386 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 479435013387 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 479435013388 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435013389 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 479435013390 active site 479435013391 homodimer interface [polypeptide binding]; other site 479435013392 catalytic site [active] 479435013393 acceptor binding site [chemical binding]; other site 479435013394 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435013395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435013396 DNA binding site [nucleotide binding] 479435013397 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 479435013398 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435013399 active site 479435013400 catalytic residues [active] 479435013401 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479435013402 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479435013403 Kelch motif; Region: Kelch_1; pfam01344 479435013404 Kelch motif; Region: Kelch_1; pfam01344 479435013405 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479435013406 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 479435013407 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435013408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435013409 DNA binding site [nucleotide binding] 479435013410 Glyco_18 domain; Region: Glyco_18; smart00636 479435013411 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 479435013412 active site 479435013413 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 479435013414 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 479435013415 ligand binding site [chemical binding]; other site 479435013416 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 479435013417 trehalose synthase; Region: treS_nterm; TIGR02456 479435013418 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 479435013419 active site 479435013420 catalytic site [active] 479435013421 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 479435013422 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 479435013423 glycogen branching enzyme; Provisional; Region: PRK05402 479435013424 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 479435013425 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 479435013426 active site 479435013427 catalytic site [active] 479435013428 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 479435013429 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435013430 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435013431 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 479435013432 nudix motif; other site 479435013433 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435013434 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013435 YCII-related domain; Region: YCII; cl00999 479435013436 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435013437 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479435013438 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 479435013439 Citrate synthase; Region: Citrate_synt; pfam00285 479435013440 oxalacetate binding site [chemical binding]; other site 479435013441 citrylCoA binding site [chemical binding]; other site 479435013442 coenzyme A binding site [chemical binding]; other site 479435013443 catalytic triad [active] 479435013444 Helix-turn-helix domain; Region: HTH_17; pfam12728 479435013445 Citrate synthase; Region: Citrate_synt; pfam00285 479435013446 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 479435013447 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 479435013448 oxalacetate binding site [chemical binding]; other site 479435013449 citrylCoA binding site [chemical binding]; other site 479435013450 coenzyme A binding site [chemical binding]; other site 479435013451 catalytic triad [active] 479435013452 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435013453 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 479435013454 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 479435013455 putative active site [active] 479435013456 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 479435013457 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 479435013458 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 479435013459 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479435013460 active site 479435013461 intersubunit interface [polypeptide binding]; other site 479435013462 catalytic residue [active] 479435013463 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 479435013464 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 479435013465 metal binding site [ion binding]; metal-binding site 479435013466 substrate binding pocket [chemical binding]; other site 479435013467 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435013468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013469 dimer interface [polypeptide binding]; other site 479435013470 conserved gate region; other site 479435013471 putative PBP binding loops; other site 479435013472 ABC-ATPase subunit interface; other site 479435013473 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435013474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013475 ABC-ATPase subunit interface; other site 479435013476 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435013477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435013478 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013479 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435013480 NAD(P) binding site [chemical binding]; other site 479435013481 active site 479435013482 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 479435013483 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435013484 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435013485 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435013486 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435013487 sugar binding site [chemical binding]; other site 479435013488 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 479435013489 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 479435013490 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 479435013491 TrkA-N domain; Region: TrkA_N; pfam02254 479435013492 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 479435013493 TrkA-N domain; Region: TrkA_N; pfam02254 479435013494 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 479435013495 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435013496 MarR family; Region: MarR; pfam01047 479435013497 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435013498 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435013499 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 479435013500 active site 479435013501 substrate binding site [chemical binding]; other site 479435013502 trimer interface [polypeptide binding]; other site 479435013503 CoA binding site [chemical binding]; other site 479435013504 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435013505 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435013506 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435013507 dimerization interface [polypeptide binding]; other site 479435013508 Bacterial PH domain; Region: DUF304; pfam03703 479435013509 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 479435013510 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 479435013511 Walker A; other site 479435013512 putative acyltransferase; Provisional; Region: PRK05790 479435013513 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435013514 dimer interface [polypeptide binding]; other site 479435013515 active site 479435013516 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 479435013517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435013518 dimer interface [polypeptide binding]; other site 479435013519 substrate binding site [chemical binding]; other site 479435013520 metal binding site [ion binding]; metal-binding site 479435013521 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 479435013522 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435013523 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435013524 ATP binding site [chemical binding]; other site 479435013525 Mg2+ binding site [ion binding]; other site 479435013526 G-X-G motif; other site 479435013527 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435013528 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 479435013529 NAD(P) binding site [chemical binding]; other site 479435013530 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479435013531 Domain of unknown function DUF20; Region: UPF0118; pfam01594 479435013532 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 479435013533 acyl-CoA esterase; Provisional; Region: PRK10673 479435013534 PGAP1-like protein; Region: PGAP1; pfam07819 479435013535 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 479435013536 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 479435013537 Peptidase family M28; Region: Peptidase_M28; pfam04389 479435013538 metal binding site [ion binding]; metal-binding site 479435013539 Fatty acid desaturase; Region: FA_desaturase; pfam00487 479435013540 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 479435013541 putative di-iron ligands [ion binding]; other site 479435013542 Putative sensor; Region: Sensor; pfam13796 479435013543 Histidine kinase; Region: HisKA_3; pfam07730 479435013544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435013545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435013546 active site 479435013547 phosphorylation site [posttranslational modification] 479435013548 intermolecular recognition site; other site 479435013549 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435013550 DNA binding residues [nucleotide binding] 479435013551 YCII-related domain; Region: YCII; cl00999 479435013552 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 479435013553 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435013554 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 479435013555 Walker A/P-loop; other site 479435013556 ATP binding site [chemical binding]; other site 479435013557 Q-loop/lid; other site 479435013558 ABC transporter signature motif; other site 479435013559 Walker B; other site 479435013560 D-loop; other site 479435013561 H-loop/switch region; other site 479435013562 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435013563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013564 dimer interface [polypeptide binding]; other site 479435013565 conserved gate region; other site 479435013566 putative PBP binding loops; other site 479435013567 ABC-ATPase subunit interface; other site 479435013568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435013569 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435013570 substrate binding pocket [chemical binding]; other site 479435013571 membrane-bound complex binding site; other site 479435013572 hinge residues; other site 479435013573 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 479435013574 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435013575 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435013576 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 479435013577 Phosphotransferase enzyme family; Region: APH; pfam01636 479435013578 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435013579 active site 479435013580 substrate binding site [chemical binding]; other site 479435013581 ATP binding site [chemical binding]; other site 479435013582 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 479435013583 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435013584 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435013585 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 479435013586 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 479435013587 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 479435013588 Methyltransferase domain; Region: Methyltransf_23; pfam13489 479435013589 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013590 S-adenosylmethionine binding site [chemical binding]; other site 479435013591 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 479435013592 hypothetical protein; Provisional; Region: PRK03298 479435013593 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 479435013594 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 479435013595 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 479435013596 glutaminase active site [active] 479435013597 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479435013598 dimer interface [polypeptide binding]; other site 479435013599 active site 479435013600 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 479435013601 dimer interface [polypeptide binding]; other site 479435013602 active site 479435013603 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 479435013604 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435013605 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 479435013606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435013607 active site 479435013608 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435013609 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435013610 DNA-binding site [nucleotide binding]; DNA binding site 479435013611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435013612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013613 homodimer interface [polypeptide binding]; other site 479435013614 catalytic residue [active] 479435013615 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 479435013616 Uncharacterized conserved protein [Function unknown]; Region: COG2128 479435013617 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 479435013618 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 479435013619 tetramer interface [polypeptide binding]; other site 479435013620 active site 479435013621 Mg2+/Mn2+ binding site [ion binding]; other site 479435013622 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 479435013623 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435013624 NAD binding site [chemical binding]; other site 479435013625 catalytic Zn binding site [ion binding]; other site 479435013626 structural Zn binding site [ion binding]; other site 479435013627 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479435013628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435013629 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435013630 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435013631 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 479435013632 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 479435013633 B12 binding site [chemical binding]; other site 479435013634 cobalt ligand [ion binding]; other site 479435013635 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435013636 anti sigma factor interaction site; other site 479435013637 regulatory phosphorylation site [posttranslational modification]; other site 479435013638 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 479435013639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435013641 DNA binding residues [nucleotide binding] 479435013642 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435013643 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435013644 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435013645 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435013646 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435013647 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435013648 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435013649 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 479435013650 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 479435013651 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 479435013652 Interdomain contacts; other site 479435013653 Cytokine receptor motif; other site 479435013654 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435013655 ATP binding site [chemical binding]; other site 479435013656 putative Mg++ binding site [ion binding]; other site 479435013657 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435013658 nucleotide binding region [chemical binding]; other site 479435013659 ATP-binding site [chemical binding]; other site 479435013660 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 479435013661 Predicted flavoprotein [General function prediction only]; Region: COG0431 479435013662 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435013663 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 479435013664 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435013665 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435013666 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 479435013667 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 479435013668 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 479435013669 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 479435013670 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 479435013671 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 479435013672 hinge; other site 479435013673 active site 479435013674 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 479435013675 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 479435013676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435013677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435013678 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435013679 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 479435013680 tandem repeat interface [polypeptide binding]; other site 479435013681 oligomer interface [polypeptide binding]; other site 479435013682 active site residues [active] 479435013683 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 479435013684 oligomer interface [polypeptide binding]; other site 479435013685 tandem repeat interface [polypeptide binding]; other site 479435013686 active site residues [active] 479435013687 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 479435013688 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 479435013689 gamma subunit interface [polypeptide binding]; other site 479435013690 LBP interface [polypeptide binding]; other site 479435013691 epsilon subunit interface [polypeptide binding]; other site 479435013692 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 479435013693 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 479435013694 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 479435013695 alpha subunit interaction interface [polypeptide binding]; other site 479435013696 Walker A motif; other site 479435013697 ATP binding site [chemical binding]; other site 479435013698 Walker B motif; other site 479435013699 inhibitor binding site; inhibition site 479435013700 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 479435013701 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 479435013702 core domain interface [polypeptide binding]; other site 479435013703 delta subunit interface [polypeptide binding]; other site 479435013704 epsilon subunit interface [polypeptide binding]; other site 479435013705 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 479435013706 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 479435013707 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 479435013708 beta subunit interaction interface [polypeptide binding]; other site 479435013709 Walker A motif; other site 479435013710 ATP binding site [chemical binding]; other site 479435013711 Walker B motif; other site 479435013712 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 479435013713 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 479435013714 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 479435013715 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 479435013716 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 479435013717 ATP synthase subunit C; Region: ATP-synt_C; cl00466 479435013718 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 479435013719 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 479435013720 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 479435013721 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 479435013722 Mg++ binding site [ion binding]; other site 479435013723 putative catalytic motif [active] 479435013724 substrate binding site [chemical binding]; other site 479435013725 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 479435013726 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 479435013727 adenosine deaminase; Provisional; Region: PRK09358 479435013728 active site 479435013729 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 479435013730 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435013731 Q-X-W motif; other site 479435013732 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 479435013733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435013734 S-adenosylmethionine binding site [chemical binding]; other site 479435013735 peptide chain release factor 1; Validated; Region: prfA; PRK00591 479435013736 This domain is found in peptide chain release factors; Region: PCRF; smart00937 479435013737 RF-1 domain; Region: RF-1; pfam00472 479435013738 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 479435013739 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 479435013740 transcription termination factor Rho; Provisional; Region: PRK12608 479435013741 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 479435013742 RNA binding site [nucleotide binding]; other site 479435013743 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 479435013744 multimer interface [polypeptide binding]; other site 479435013745 Walker A motif; other site 479435013746 ATP binding site [chemical binding]; other site 479435013747 Walker B motif; other site 479435013748 homoserine kinase; Provisional; Region: PRK01212 479435013749 threonine synthase; Reviewed; Region: PRK06721 479435013750 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 479435013751 homodimer interface [polypeptide binding]; other site 479435013752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435013753 catalytic residue [active] 479435013754 homoserine dehydrogenase; Provisional; Region: PRK06349 479435013755 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 479435013756 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 479435013757 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435013758 diaminopimelate decarboxylase; Region: lysA; TIGR01048 479435013759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 479435013760 active site 479435013761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435013762 substrate binding site [chemical binding]; other site 479435013763 catalytic residues [active] 479435013764 dimer interface [polypeptide binding]; other site 479435013765 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 479435013766 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 479435013767 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 479435013768 active site 479435013769 HIGH motif; other site 479435013770 KMSK motif region; other site 479435013771 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 479435013772 tRNA binding surface [nucleotide binding]; other site 479435013773 anticodon binding site; other site 479435013774 PspC domain; Region: PspC; pfam04024 479435013775 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 479435013776 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 479435013777 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435013778 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435013779 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435013780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435013781 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435013782 YCII-related domain; Region: YCII; cl00999 479435013783 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 479435013784 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 479435013785 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 479435013786 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 479435013787 Uncharacterized conserved protein [Function unknown]; Region: COG2128 479435013788 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 479435013789 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 479435013790 active site 479435013791 SAM binding site [chemical binding]; other site 479435013792 homodimer interface [polypeptide binding]; other site 479435013793 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 479435013794 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 479435013795 putative sugar binding site [chemical binding]; other site 479435013796 catalytic residues [active] 479435013797 precorrin-3B synthase; Region: CobG; TIGR02435 479435013798 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 479435013799 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 479435013800 Precorrin-8X methylmutase; Region: CbiC; pfam02570 479435013801 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 479435013802 active site 479435013803 SAM binding site [chemical binding]; other site 479435013804 homodimer interface [polypeptide binding]; other site 479435013805 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 479435013806 active site 479435013807 SAM binding site [chemical binding]; other site 479435013808 homodimer interface [polypeptide binding]; other site 479435013809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 479435013810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479435013811 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435013812 dimerization interface [polypeptide binding]; other site 479435013813 putative DNA binding site [nucleotide binding]; other site 479435013814 putative Zn2+ binding site [ion binding]; other site 479435013815 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 479435013816 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 479435013817 active site 479435013818 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 479435013819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435013820 ATP binding site [chemical binding]; other site 479435013821 putative Mg++ binding site [ion binding]; other site 479435013822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435013823 nucleotide binding region [chemical binding]; other site 479435013824 ATP-binding site [chemical binding]; other site 479435013825 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 479435013826 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435013827 diacylglycerol kinase; Reviewed; Region: PRK11914 479435013828 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 479435013829 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 479435013830 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 479435013831 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435013832 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435013833 WYL domain; Region: WYL; pfam13280 479435013834 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435013835 WYL domain; Region: WYL; pfam13280 479435013836 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 479435013837 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 479435013838 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 479435013839 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 479435013840 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435013841 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013842 dimer interface [polypeptide binding]; other site 479435013843 conserved gate region; other site 479435013844 putative PBP binding loops; other site 479435013845 ABC-ATPase subunit interface; other site 479435013846 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435013847 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435013848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013849 dimer interface [polypeptide binding]; other site 479435013850 conserved gate region; other site 479435013851 putative PBP binding loops; other site 479435013852 ABC-ATPase subunit interface; other site 479435013853 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435013854 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435013855 Walker A/P-loop; other site 479435013856 ATP binding site [chemical binding]; other site 479435013857 Q-loop/lid; other site 479435013858 ABC transporter signature motif; other site 479435013859 Walker B; other site 479435013860 D-loop; other site 479435013861 H-loop/switch region; other site 479435013862 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479435013863 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435013864 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435013865 Walker A/P-loop; other site 479435013866 ATP binding site [chemical binding]; other site 479435013867 Q-loop/lid; other site 479435013868 ABC transporter signature motif; other site 479435013869 Walker B; other site 479435013870 D-loop; other site 479435013871 H-loop/switch region; other site 479435013872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435013873 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 479435013874 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 479435013875 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 479435013876 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479435013877 RNA binding surface [nucleotide binding]; other site 479435013878 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 479435013879 active site 479435013880 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 479435013881 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 479435013882 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435013883 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479435013884 P-loop; other site 479435013885 Magnesium ion binding site [ion binding]; other site 479435013886 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479435013887 Magnesium ion binding site [ion binding]; other site 479435013888 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435013889 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435013890 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 479435013891 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 479435013892 active site 479435013893 DNA binding site [nucleotide binding] 479435013894 Int/Topo IB signature motif; other site 479435013895 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 479435013896 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 479435013897 hexamer interface [polypeptide binding]; other site 479435013898 ligand binding site [chemical binding]; other site 479435013899 putative active site [active] 479435013900 NAD(P) binding site [chemical binding]; other site 479435013901 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435013902 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 479435013903 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 479435013904 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 479435013905 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 479435013906 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435013907 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435013908 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 479435013909 homodimer interface [polypeptide binding]; other site 479435013910 homotetramer interface [polypeptide binding]; other site 479435013911 active site pocket [active] 479435013912 cleavage site 479435013913 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435013914 active site 479435013915 catalytic residues [active] 479435013916 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 479435013917 HTH domain; Region: HTH_11; pfam08279 479435013918 WYL domain; Region: WYL; pfam13280 479435013919 Beta/Gamma crystallin; Region: Crystall; cl02528 479435013920 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 479435013921 homopentamer interface [polypeptide binding]; other site 479435013922 active site 479435013923 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 479435013924 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 479435013925 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 479435013926 dimerization interface [polypeptide binding]; other site 479435013927 active site 479435013928 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 479435013929 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 479435013930 Lumazine binding domain; Region: Lum_binding; pfam00677 479435013931 Lumazine binding domain; Region: Lum_binding; pfam00677 479435013932 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 479435013933 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 479435013934 catalytic motif [active] 479435013935 Zn binding site [ion binding]; other site 479435013936 RibD C-terminal domain; Region: RibD_C; cl17279 479435013937 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435013938 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435013939 Walker A/P-loop; other site 479435013940 ATP binding site [chemical binding]; other site 479435013941 Q-loop/lid; other site 479435013942 ABC transporter signature motif; other site 479435013943 Walker B; other site 479435013944 D-loop; other site 479435013945 H-loop/switch region; other site 479435013946 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435013947 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435013948 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435013949 active site 479435013950 ATP binding site [chemical binding]; other site 479435013951 substrate binding site [chemical binding]; other site 479435013952 activation loop (A-loop); other site 479435013953 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435013954 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435013955 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435013956 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435013957 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435013958 substrate binding pocket [chemical binding]; other site 479435013959 membrane-bound complex binding site; other site 479435013960 hinge residues; other site 479435013961 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435013962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435013963 dimer interface [polypeptide binding]; other site 479435013964 conserved gate region; other site 479435013965 putative PBP binding loops; other site 479435013966 ABC-ATPase subunit interface; other site 479435013967 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435013968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435013969 Walker A/P-loop; other site 479435013970 ATP binding site [chemical binding]; other site 479435013971 Q-loop/lid; other site 479435013972 ABC transporter signature motif; other site 479435013973 Walker B; other site 479435013974 D-loop; other site 479435013975 H-loop/switch region; other site 479435013976 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 479435013977 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 479435013978 NodB motif; other site 479435013979 active site 479435013980 catalytic site [active] 479435013981 metal binding site [ion binding]; metal-binding site 479435013982 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 479435013983 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435013984 active site 479435013985 motif I; other site 479435013986 motif II; other site 479435013987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435013988 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 479435013989 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 479435013990 substrate binding site [chemical binding]; other site 479435013991 hexamer interface [polypeptide binding]; other site 479435013992 metal binding site [ion binding]; metal-binding site 479435013993 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 479435013994 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 479435013995 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 479435013996 active site 479435013997 SAM binding site [chemical binding]; other site 479435013998 homodimer interface [polypeptide binding]; other site 479435013999 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 479435014000 active site 479435014001 putative homodimer interface [polypeptide binding]; other site 479435014002 SAM binding site [chemical binding]; other site 479435014003 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 479435014004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435014005 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435014006 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 479435014007 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435014008 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435014009 Walker A/P-loop; other site 479435014010 ATP binding site [chemical binding]; other site 479435014011 Q-loop/lid; other site 479435014012 ABC transporter signature motif; other site 479435014013 Walker B; other site 479435014014 D-loop; other site 479435014015 H-loop/switch region; other site 479435014016 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 479435014017 MarR family; Region: MarR_2; cl17246 479435014018 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435014019 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435014020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435014021 non-specific DNA binding site [nucleotide binding]; other site 479435014022 salt bridge; other site 479435014023 sequence-specific DNA binding site [nucleotide binding]; other site 479435014024 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014025 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014026 DNA binding site [nucleotide binding] 479435014027 domain linker motif; other site 479435014028 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435014029 ligand binding site [chemical binding]; other site 479435014030 dimerization interface [polypeptide binding]; other site 479435014031 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 479435014032 Methyltransferase domain; Region: Methyltransf_25; pfam13649 479435014033 S-adenosylmethionine binding site [chemical binding]; other site 479435014034 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 479435014035 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 479435014036 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 479435014037 putative active site [active] 479435014038 putative dimer interface [polypeptide binding]; other site 479435014039 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 479435014040 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 479435014041 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 479435014042 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 479435014043 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435014044 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435014045 Walker A/P-loop; other site 479435014046 ATP binding site [chemical binding]; other site 479435014047 Q-loop/lid; other site 479435014048 ABC transporter signature motif; other site 479435014049 Walker B; other site 479435014050 D-loop; other site 479435014051 H-loop/switch region; other site 479435014052 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 479435014053 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435014054 ABC-ATPase subunit interface; other site 479435014055 dimer interface [polypeptide binding]; other site 479435014056 putative PBP binding regions; other site 479435014057 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435014058 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435014059 ABC-ATPase subunit interface; other site 479435014060 dimer interface [polypeptide binding]; other site 479435014061 putative PBP binding regions; other site 479435014062 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 479435014063 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 479435014064 siderophore binding site; other site 479435014065 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 479435014066 hypothetical protein; Provisional; Region: PRK14059 479435014067 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 479435014068 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 479435014069 dihydropteroate synthase; Region: DHPS; TIGR01496 479435014070 substrate binding pocket [chemical binding]; other site 479435014071 dimer interface [polypeptide binding]; other site 479435014072 inhibitor binding site; inhibition site 479435014073 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 479435014074 Human rTS beta is encoded by the rTS gene which, through alternative RNA splicing, also encodes rTS alpha whose mRNA is complementary to thymidylate synthase mRNA. rTS beta expression is associated with the production of small molecules that appear to...; Region: rTSbeta_L-fuconate_dehydratase; cd03324 479435014075 putative active site pocket [active] 479435014076 metal binding site [ion binding]; metal-binding site 479435014077 classical (c) SDRs; Region: SDR_c; cd05233 479435014078 NAD(P) binding site [chemical binding]; other site 479435014079 active site 479435014080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435014081 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435014082 active site 479435014083 catalytic tetrad [active] 479435014084 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435014085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435014086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435014087 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 479435014088 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 479435014089 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 479435014090 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 479435014091 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435014092 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 479435014093 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 479435014094 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 479435014095 active site 479435014096 metal-binding site 479435014097 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435014098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435014099 Walker A/P-loop; other site 479435014100 ATP binding site [chemical binding]; other site 479435014101 Q-loop/lid; other site 479435014102 ABC transporter signature motif; other site 479435014103 Walker B; other site 479435014104 D-loop; other site 479435014105 H-loop/switch region; other site 479435014106 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435014107 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435014108 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435014109 DNA-binding site [nucleotide binding]; DNA binding site 479435014110 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 479435014111 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 479435014112 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479435014113 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 479435014114 TPP-binding site [chemical binding]; other site 479435014115 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 479435014116 dimer interface [polypeptide binding]; other site 479435014117 PYR/PP interface [polypeptide binding]; other site 479435014118 TPP binding site [chemical binding]; other site 479435014119 Predicted ATPase [General function prediction only]; Region: COG3910 479435014120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435014121 Walker A/P-loop; other site 479435014122 ATP binding site [chemical binding]; other site 479435014123 Q-loop/lid; other site 479435014124 ABC transporter signature motif; other site 479435014125 Walker B; other site 479435014126 D-loop; other site 479435014127 H-loop/switch region; other site 479435014128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014129 dimerization interface [polypeptide binding]; other site 479435014130 putative DNA binding site [nucleotide binding]; other site 479435014131 putative Zn2+ binding site [ion binding]; other site 479435014132 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 479435014133 Transcription factor WhiB; Region: Whib; pfam02467 479435014134 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 479435014135 4Fe-4S binding domain; Region: Fer4; pfam00037 479435014136 ferredoxin-NADP+ reductase; Region: PLN02852 479435014137 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 479435014138 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435014139 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435014140 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435014141 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435014142 NAD(P) binding site [chemical binding]; other site 479435014143 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 479435014144 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 479435014145 Malic enzyme, N-terminal domain; Region: malic; pfam00390 479435014146 Malic enzyme, NAD binding domain; Region: Malic_M; smart00919 479435014147 NAD(P) binding pocket [chemical binding]; other site 479435014148 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 479435014149 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435014150 substrate binding pocket [chemical binding]; other site 479435014151 membrane-bound complex binding site; other site 479435014152 hinge residues; other site 479435014153 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 479435014154 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014155 dimer interface [polypeptide binding]; other site 479435014156 conserved gate region; other site 479435014157 putative PBP binding loops; other site 479435014158 ABC-ATPase subunit interface; other site 479435014159 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 479435014160 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 479435014161 Walker A/P-loop; other site 479435014162 ATP binding site [chemical binding]; other site 479435014163 Q-loop/lid; other site 479435014164 ABC transporter signature motif; other site 479435014165 Walker B; other site 479435014166 D-loop; other site 479435014167 H-loop/switch region; other site 479435014168 Predicted membrane protein [Function unknown]; Region: COG1470 479435014169 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435014170 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435014171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 479435014172 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435014173 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 479435014174 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014175 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 479435014176 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014177 DNA binding residues [nucleotide binding] 479435014178 Transcription factor WhiB; Region: Whib; pfam02467 479435014179 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 479435014180 PAS fold; Region: PAS_4; pfam08448 479435014181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 479435014182 Histidine kinase; Region: HisKA_2; pfam07568 479435014183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435014184 ATP binding site [chemical binding]; other site 479435014185 Mg2+ binding site [ion binding]; other site 479435014186 G-X-G motif; other site 479435014187 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 479435014188 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 479435014189 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435014190 putative catalytic site [active] 479435014191 putative phosphate binding site [ion binding]; other site 479435014192 putative metal binding site [ion binding]; other site 479435014193 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 479435014194 Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322 479435014195 Na binding site [ion binding]; other site 479435014196 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 479435014197 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 479435014198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435014199 Zn2+ binding site [ion binding]; other site 479435014200 Mg2+ binding site [ion binding]; other site 479435014201 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435014202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435014203 non-specific DNA binding site [nucleotide binding]; other site 479435014204 salt bridge; other site 479435014205 sequence-specific DNA binding site [nucleotide binding]; other site 479435014206 NB-ARC domain; Region: NB-ARC; pfam00931 479435014207 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435014208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435014209 TPR motif; other site 479435014210 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435014211 binding surface 479435014212 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435014213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435014214 TPR motif; other site 479435014215 binding surface 479435014216 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; TIGR03988 479435014217 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 479435014218 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014219 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014220 DNA binding residues [nucleotide binding] 479435014221 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435014222 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 479435014223 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435014224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014225 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435014226 Putative zinc-finger; Region: zf-HC2; pfam13490 479435014227 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 479435014228 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 479435014229 Dimer interface [polypeptide binding]; other site 479435014230 anticodon binding site; other site 479435014231 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435014232 motif 1; other site 479435014233 dimer interface [polypeptide binding]; other site 479435014234 active site 479435014235 motif 2; other site 479435014236 motif 3; other site 479435014237 acetylornithine deacetylase; Validated; Region: PRK06915 479435014238 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like2; cd03895 479435014239 metal binding site [ion binding]; metal-binding site 479435014240 dimer interface [polypeptide binding]; other site 479435014241 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 479435014242 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 479435014243 hinge; other site 479435014244 active site 479435014245 Predicted GTPases [General function prediction only]; Region: COG1162 479435014246 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 479435014247 GTPase/Zn-binding domain interface [polypeptide binding]; other site 479435014248 GTP/Mg2+ binding site [chemical binding]; other site 479435014249 G4 box; other site 479435014250 G1 box; other site 479435014251 Switch I region; other site 479435014252 G2 box; other site 479435014253 G3 box; other site 479435014254 Switch II region; other site 479435014255 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479435014256 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 479435014257 active site 479435014258 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 479435014259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014260 NAD(P) binding site [chemical binding]; other site 479435014261 active site 479435014262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435014263 salt bridge; other site 479435014264 non-specific DNA binding site [nucleotide binding]; other site 479435014265 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435014266 sequence-specific DNA binding site [nucleotide binding]; other site 479435014267 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014268 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014269 FOG: CBS domain [General function prediction only]; Region: COG0517 479435014270 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 479435014271 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435014272 active site 479435014273 catalytic residues [active] 479435014274 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 479435014275 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479435014276 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479435014277 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435014278 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 479435014279 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 479435014280 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 479435014281 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014282 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435014283 putative substrate translocation pore; other site 479435014284 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435014285 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014286 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014287 DNA binding residues [nucleotide binding] 479435014288 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 479435014289 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435014290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014291 dimer interface [polypeptide binding]; other site 479435014292 conserved gate region; other site 479435014293 putative PBP binding loops; other site 479435014294 ABC-ATPase subunit interface; other site 479435014295 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435014296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014297 dimer interface [polypeptide binding]; other site 479435014298 conserved gate region; other site 479435014299 putative PBP binding loops; other site 479435014300 ABC-ATPase subunit interface; other site 479435014301 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435014302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435014303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435014304 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014305 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 479435014306 Phosphotransferase enzyme family; Region: APH; pfam01636 479435014307 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435014308 active site 479435014309 substrate binding site [chemical binding]; other site 479435014310 ATP binding site [chemical binding]; other site 479435014311 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435014312 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435014313 Walker A/P-loop; other site 479435014314 ATP binding site [chemical binding]; other site 479435014315 Q-loop/lid; other site 479435014316 ABC transporter signature motif; other site 479435014317 Walker B; other site 479435014318 D-loop; other site 479435014319 H-loop/switch region; other site 479435014320 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435014321 FtsX-like permease family; Region: FtsX; pfam02687 479435014322 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435014323 FtsX-like permease family; Region: FtsX; pfam02687 479435014324 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435014325 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 479435014326 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 479435014327 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 479435014328 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435014329 Histidine kinase; Region: HisKA_3; pfam07730 479435014330 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435014331 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435014332 DNA binding residues [nucleotide binding] 479435014333 dimerization interface [polypeptide binding]; other site 479435014334 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435014335 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 479435014336 NADP binding site [chemical binding]; other site 479435014337 homodimer interface [polypeptide binding]; other site 479435014338 active site 479435014339 substrate binding site [chemical binding]; other site 479435014340 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435014341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014342 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435014343 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435014344 MarR family; Region: MarR; pfam01047 479435014345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014346 dimerization interface [polypeptide binding]; other site 479435014347 putative DNA binding site [nucleotide binding]; other site 479435014348 putative Zn2+ binding site [ion binding]; other site 479435014349 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 479435014350 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 479435014351 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 479435014352 putative dimerization interface [polypeptide binding]; other site 479435014353 putative ligand binding site [chemical binding]; other site 479435014354 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479435014355 beta-galactosidase; Region: BGL; TIGR03356 479435014356 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435014357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014358 dimer interface [polypeptide binding]; other site 479435014359 conserved gate region; other site 479435014360 putative PBP binding loops; other site 479435014361 ABC-ATPase subunit interface; other site 479435014362 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435014363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014364 putative PBP binding loops; other site 479435014365 dimer interface [polypeptide binding]; other site 479435014366 ABC-ATPase subunit interface; other site 479435014367 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435014368 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435014369 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435014370 active site 479435014371 metal binding site [ion binding]; metal-binding site 479435014372 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 479435014373 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435014374 DNA binding residues [nucleotide binding] 479435014375 drug binding residues [chemical binding]; other site 479435014376 dimer interface [polypeptide binding]; other site 479435014377 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 479435014378 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 479435014379 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 479435014380 Ricin-type beta-trefoil; Region: RICIN; smart00458 479435014381 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435014382 putative sugar binding sites [chemical binding]; other site 479435014383 Q-X-W motif; other site 479435014384 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 479435014385 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 479435014386 active site 479435014387 catalytic residues [active] 479435014388 Ricin-type beta-trefoil; Region: RICIN; smart00458 479435014389 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435014390 putative sugar binding sites [chemical binding]; other site 479435014391 Q-X-W motif; other site 479435014392 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435014393 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435014394 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435014395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014397 DNA binding residues [nucleotide binding] 479435014398 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 479435014399 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479435014400 beta-galactosidase; Region: BGL; TIGR03356 479435014401 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435014402 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435014403 nucleotide binding site [chemical binding]; other site 479435014404 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014405 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014406 DNA binding site [nucleotide binding] 479435014407 domain linker motif; other site 479435014408 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435014409 dimerization interface [polypeptide binding]; other site 479435014410 ligand binding site [chemical binding]; other site 479435014411 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435014412 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 479435014413 substrate binding site [chemical binding]; other site 479435014414 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435014415 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435014416 Walker A/P-loop; other site 479435014417 ATP binding site [chemical binding]; other site 479435014418 Q-loop/lid; other site 479435014419 ABC transporter signature motif; other site 479435014420 Walker B; other site 479435014421 D-loop; other site 479435014422 H-loop/switch region; other site 479435014423 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 479435014424 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435014425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014426 dimer interface [polypeptide binding]; other site 479435014427 conserved gate region; other site 479435014428 putative PBP binding loops; other site 479435014429 ABC-ATPase subunit interface; other site 479435014430 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435014431 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 479435014432 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014433 dimer interface [polypeptide binding]; other site 479435014434 conserved gate region; other site 479435014435 putative PBP binding loops; other site 479435014436 ABC-ATPase subunit interface; other site 479435014437 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 479435014438 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435014439 Walker A/P-loop; other site 479435014440 ATP binding site [chemical binding]; other site 479435014441 Q-loop/lid; other site 479435014442 ABC transporter signature motif; other site 479435014443 Walker B; other site 479435014444 D-loop; other site 479435014445 H-loop/switch region; other site 479435014446 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 479435014447 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 479435014448 beta-galactosidase; Region: BGL; TIGR03356 479435014449 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435014450 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435014451 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435014452 putative active site [active] 479435014453 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 479435014454 Family description; Region: VCBS; pfam13517 479435014455 Family description; Region: VCBS; pfam13517 479435014456 Family description; Region: VCBS; pfam13517 479435014457 Family description; Region: VCBS; pfam13517 479435014458 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 479435014459 catalytic site [active] 479435014460 BNR repeat-like domain; Region: BNR_2; pfam13088 479435014461 Asp-box motif; other site 479435014462 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 479435014463 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 479435014464 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 479435014465 ligand binding site [chemical binding]; other site 479435014466 flexible hinge region; other site 479435014467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435014468 ATP binding site [chemical binding]; other site 479435014469 Mg2+ binding site [ion binding]; other site 479435014470 G-X-G motif; other site 479435014471 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 479435014472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435014473 active site 479435014474 phosphorylation site [posttranslational modification] 479435014475 intermolecular recognition site; other site 479435014476 dimerization interface [polypeptide binding]; other site 479435014477 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 479435014478 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479435014479 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435014480 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435014481 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 479435014482 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 479435014483 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 479435014484 putative active site [active] 479435014485 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 479435014486 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 479435014487 homodimer interface [polypeptide binding]; other site 479435014488 substrate-cofactor binding pocket; other site 479435014489 catalytic residue [active] 479435014490 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 479435014491 nucleotide binding site [chemical binding]; other site 479435014492 FemAB family; Region: FemAB; pfam02388 479435014493 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 479435014494 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 479435014495 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479435014496 active site 479435014497 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435014498 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014499 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435014500 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435014501 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435014502 Walker A/P-loop; other site 479435014503 ATP binding site [chemical binding]; other site 479435014504 Q-loop/lid; other site 479435014505 ABC transporter signature motif; other site 479435014506 Walker B; other site 479435014507 D-loop; other site 479435014508 H-loop/switch region; other site 479435014509 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435014510 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435014511 Uncharacterized conserved protein [Function unknown]; Region: COG1359 479435014512 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 479435014513 SnoaL-like domain; Region: SnoaL_3; pfam13474 479435014514 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 479435014515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435014516 non-specific DNA binding site [nucleotide binding]; other site 479435014517 salt bridge; other site 479435014518 sequence-specific DNA binding site [nucleotide binding]; other site 479435014519 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435014520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435014521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435014522 Walker A/P-loop; other site 479435014523 ATP binding site [chemical binding]; other site 479435014524 Q-loop/lid; other site 479435014525 ABC transporter signature motif; other site 479435014526 Walker B; other site 479435014527 D-loop; other site 479435014528 H-loop/switch region; other site 479435014529 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435014530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435014531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435014532 Walker A/P-loop; other site 479435014533 ATP binding site [chemical binding]; other site 479435014534 Q-loop/lid; other site 479435014535 ABC transporter signature motif; other site 479435014536 Walker B; other site 479435014537 D-loop; other site 479435014538 H-loop/switch region; other site 479435014539 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435014540 active site 479435014541 catalytic residues [active] 479435014542 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435014543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014544 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014545 DNA binding residues [nucleotide binding] 479435014546 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 479435014547 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 479435014548 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 479435014549 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 479435014550 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 479435014551 MoaE homodimer interface [polypeptide binding]; other site 479435014552 MoaD interaction [polypeptide binding]; other site 479435014553 active site residues [active] 479435014554 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 479435014555 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 479435014556 nudix motif; other site 479435014557 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 479435014558 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435014559 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014560 putative DNA binding site [nucleotide binding]; other site 479435014561 putative Zn2+ binding site [ion binding]; other site 479435014562 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 479435014563 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 479435014564 putative NAD(P) binding site [chemical binding]; other site 479435014565 GAF domain; Region: GAF; pfam01590 479435014566 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 479435014567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014568 metabolite-proton symporter; Region: 2A0106; TIGR00883 479435014569 putative substrate translocation pore; other site 479435014570 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 479435014571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435014572 NAD(P) binding site [chemical binding]; other site 479435014573 active site 479435014574 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 479435014575 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 479435014576 metal binding site [ion binding]; metal-binding site 479435014577 active site 479435014578 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 479435014579 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 479435014580 putative molybdopterin cofactor binding site [chemical binding]; other site 479435014581 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 479435014582 putative molybdopterin cofactor binding site; other site 479435014583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014584 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435014585 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435014586 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435014587 MMPL family; Region: MMPL; pfam03176 479435014588 MMPL family; Region: MMPL; pfam03176 479435014589 Protein of unknown function DUF45; Region: DUF45; pfam01863 479435014590 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 479435014591 ABC1 family; Region: ABC1; pfam03109 479435014592 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435014593 active site 479435014594 ATP binding site [chemical binding]; other site 479435014595 Transcription factor WhiB; Region: Whib; pfam02467 479435014596 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 479435014597 Part of AAA domain; Region: AAA_19; pfam13245 479435014598 Family description; Region: UvrD_C_2; pfam13538 479435014599 HRDC domain; Region: HRDC; pfam00570 479435014600 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 479435014601 catalytic residues [active] 479435014602 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 479435014603 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 479435014604 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 479435014605 putative NADH binding site [chemical binding]; other site 479435014606 putative active site [active] 479435014607 nudix motif; other site 479435014608 putative metal binding site [ion binding]; other site 479435014609 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 479435014610 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 479435014611 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 479435014612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 479435014613 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 479435014614 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 479435014615 IucA / IucC family; Region: IucA_IucC; pfam04183 479435014616 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 479435014617 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 479435014618 putative active site [active] 479435014619 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 479435014620 putative active site [active] 479435014621 AAA domain; Region: AAA_30; pfam13604 479435014622 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479435014623 Family description; Region: UvrD_C_2; pfam13538 479435014624 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479435014625 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 479435014626 Family description; Region: UvrD_C_2; pfam13538 479435014627 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 479435014628 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435014629 DNA binding site [nucleotide binding] 479435014630 active site 479435014631 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435014632 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435014633 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 479435014634 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 479435014635 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 479435014636 ATP binding site [chemical binding]; other site 479435014637 substrate interface [chemical binding]; other site 479435014638 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 479435014639 active site residue [active] 479435014640 Calx-beta domain; Region: Calx-beta; cl02522 479435014641 PGAP1-like protein; Region: PGAP1; pfam07819 479435014642 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435014643 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 479435014644 nucleotide binding site [chemical binding]; other site 479435014645 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435014646 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014647 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 479435014648 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 479435014649 dinuclear metal binding motif [ion binding]; other site 479435014650 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 479435014651 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435014652 ATP binding site [chemical binding]; other site 479435014653 Mg++ binding site [ion binding]; other site 479435014654 motif III; other site 479435014655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435014656 nucleotide binding region [chemical binding]; other site 479435014657 ATP-binding site [chemical binding]; other site 479435014658 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 479435014659 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435014660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435014661 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479435014662 Magnesium ion binding site [ion binding]; other site 479435014663 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435014664 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014665 putative substrate translocation pore; other site 479435014666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014667 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 479435014668 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435014669 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435014670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014672 DNA binding residues [nucleotide binding] 479435014673 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 479435014674 metal binding triad [ion binding]; metal-binding site 479435014675 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435014676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435014677 Walker A/P-loop; other site 479435014678 ATP binding site [chemical binding]; other site 479435014679 Q-loop/lid; other site 479435014680 ABC transporter signature motif; other site 479435014681 Walker B; other site 479435014682 D-loop; other site 479435014683 H-loop/switch region; other site 479435014684 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 479435014685 ABC-2 family transporter protein; Region: ABC2_membrane_6; pfam06182 479435014686 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 479435014687 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 479435014688 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 479435014689 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 479435014690 active site 479435014691 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 479435014692 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435014693 nudix motif; other site 479435014694 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 479435014695 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435014696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435014697 ATP binding site [chemical binding]; other site 479435014698 Mg2+ binding site [ion binding]; other site 479435014699 G-X-G motif; other site 479435014700 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 479435014701 GAF domain; Region: GAF; pfam01590 479435014702 GAF domain; Region: GAF_2; pfam13185 479435014703 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 479435014704 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 479435014705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435014706 Mg2+ binding site [ion binding]; other site 479435014707 G-X-G motif; other site 479435014708 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435014709 anti sigma factor interaction site; other site 479435014710 regulatory phosphorylation site [posttranslational modification]; other site 479435014711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435014712 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435014713 catalytic core [active] 479435014714 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014715 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014716 DNA binding site [nucleotide binding] 479435014717 domain linker motif; other site 479435014718 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435014719 ligand binding site [chemical binding]; other site 479435014720 dimerization interface [polypeptide binding]; other site 479435014721 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435014722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435014723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014724 dimer interface [polypeptide binding]; other site 479435014725 putative PBP binding loops; other site 479435014726 ABC-ATPase subunit interface; other site 479435014727 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435014728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014729 dimer interface [polypeptide binding]; other site 479435014730 conserved gate region; other site 479435014731 putative PBP binding loops; other site 479435014732 ABC-ATPase subunit interface; other site 479435014733 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 479435014734 Putative glucoamylase; Region: Glycoamylase; pfam10091 479435014735 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 479435014736 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 479435014737 putative active site [active] 479435014738 putative catalytic site [active] 479435014739 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014740 dimerization interface [polypeptide binding]; other site 479435014741 putative DNA binding site [nucleotide binding]; other site 479435014742 putative Zn2+ binding site [ion binding]; other site 479435014743 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435014744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435014745 NB-ARC domain; Region: NB-ARC; pfam00931 479435014746 AAA domain; Region: AAA_14; pfam13173 479435014747 Walker A motif; other site 479435014748 ATP binding site [chemical binding]; other site 479435014749 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 479435014750 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435014751 binding surface 479435014752 TPR motif; other site 479435014753 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 479435014754 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 479435014755 oligomer interface [polypeptide binding]; other site 479435014756 metal binding site [ion binding]; metal-binding site 479435014757 metal binding site [ion binding]; metal-binding site 479435014758 putative Cl binding site [ion binding]; other site 479435014759 basic sphincter; other site 479435014760 hydrophobic gate; other site 479435014761 periplasmic entrance; other site 479435014762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014763 putative DNA binding site [nucleotide binding]; other site 479435014764 putative Zn2+ binding site [ion binding]; other site 479435014765 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435014766 dimerization interface [polypeptide binding]; other site 479435014767 putative DNA binding site [nucleotide binding]; other site 479435014768 putative Zn2+ binding site [ion binding]; other site 479435014769 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435014770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435014771 active site 479435014772 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435014773 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435014774 active site 479435014775 ATP binding site [chemical binding]; other site 479435014776 substrate binding site [chemical binding]; other site 479435014777 activation loop (A-loop); other site 479435014778 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435014779 active site 479435014780 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 479435014781 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435014782 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014783 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014784 DNA binding residues [nucleotide binding] 479435014785 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 479435014786 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 479435014787 DNA binding residues [nucleotide binding] 479435014788 dimerization interface [polypeptide binding]; other site 479435014789 PRC-barrel domain; Region: PRC; pfam05239 479435014790 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 479435014791 MgtE intracellular N domain; Region: MgtE_N; smart00924 479435014792 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 479435014793 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 479435014794 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 479435014795 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 479435014796 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 479435014797 Walker A motif; other site 479435014798 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435014799 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435014800 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435014801 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 479435014802 active site 479435014803 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 479435014804 dimer interface [polypeptide binding]; other site 479435014805 active site 479435014806 ADP-ribose binding site [chemical binding]; other site 479435014807 nudix motif; other site 479435014808 metal binding site [ion binding]; metal-binding site 479435014809 CTP synthetase; Validated; Region: pyrG; PRK05380 479435014810 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 479435014811 Catalytic site [active] 479435014812 active site 479435014813 UTP binding site [chemical binding]; other site 479435014814 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 479435014815 active site 479435014816 putative oxyanion hole; other site 479435014817 catalytic triad [active] 479435014818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 479435014819 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435014820 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 479435014821 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 479435014822 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 479435014823 Thiamine pyrophosphokinase; Region: TPK; cl08415 479435014824 active site 479435014825 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 479435014826 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 479435014827 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 479435014828 Walker A/P-loop; other site 479435014829 ATP binding site [chemical binding]; other site 479435014830 Q-loop/lid; other site 479435014831 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 479435014832 ABC transporter signature motif; other site 479435014833 Walker B; other site 479435014834 D-loop; other site 479435014835 H-loop/switch region; other site 479435014836 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 479435014837 ATP-NAD kinase; Region: NAD_kinase; pfam01513 479435014838 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 479435014839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435014840 S-adenosylmethionine binding site [chemical binding]; other site 479435014841 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 479435014842 phosphoglycolate/pyridoxal phosphate phosphatase family; Region: PGP_euk; TIGR01452 479435014843 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435014844 motif II; other site 479435014845 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 479435014846 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 479435014847 Uncharacterized conserved protein [Function unknown]; Region: COG4198 479435014848 tetratricopeptide repeat protein; Provisional; Region: PRK11788 479435014849 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 479435014850 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 479435014851 active site 479435014852 HIGH motif; other site 479435014853 dimer interface [polypeptide binding]; other site 479435014854 KMSKS motif; other site 479435014855 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479435014856 RNA binding surface [nucleotide binding]; other site 479435014857 Uncharacterized conserved protein [Function unknown]; Region: COG4850 479435014858 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 479435014859 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 479435014860 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435014861 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 479435014862 active site 479435014863 DNA binding site [nucleotide binding] 479435014864 argininosuccinate lyase; Provisional; Region: PRK00855 479435014865 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 479435014866 active sites [active] 479435014867 tetramer interface [polypeptide binding]; other site 479435014868 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 479435014869 Arginine repressor [Transcription]; Region: ArgR; COG1438 479435014870 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 479435014871 ornithine carbamoyltransferase; Provisional; Region: PRK00779 479435014872 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 479435014873 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 479435014874 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 479435014875 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479435014876 inhibitor-cofactor binding pocket; inhibition site 479435014877 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435014878 catalytic residue [active] 479435014879 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 479435014880 feedback inhibition sensing region; other site 479435014881 homohexameric interface [polypeptide binding]; other site 479435014882 nucleotide binding site [chemical binding]; other site 479435014883 N-acetyl-L-glutamate binding site [chemical binding]; other site 479435014884 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 479435014885 heterotetramer interface [polypeptide binding]; other site 479435014886 active site pocket [active] 479435014887 cleavage site 479435014888 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 479435014889 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 479435014890 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 479435014891 Uncharacterized conserved protein [Function unknown]; Region: COG2128 479435014892 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 479435014893 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435014894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435014895 DNA binding residues [nucleotide binding] 479435014896 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435014897 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435014898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435014899 Coenzyme A binding pocket [chemical binding]; other site 479435014900 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014901 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014902 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014903 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014904 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014905 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014906 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014907 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014908 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014909 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014910 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014911 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014912 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 479435014913 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 479435014914 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 479435014915 Ligand binding site; other site 479435014916 Putative Catalytic site; other site 479435014917 DXD motif; other site 479435014918 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 479435014919 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 479435014920 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 479435014921 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 479435014922 putative tRNA-binding site [nucleotide binding]; other site 479435014923 B3/4 domain; Region: B3_4; pfam03483 479435014924 tRNA synthetase B5 domain; Region: B5; smart00874 479435014925 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 479435014926 dimer interface [polypeptide binding]; other site 479435014927 motif 1; other site 479435014928 motif 3; other site 479435014929 motif 2; other site 479435014930 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 479435014931 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 479435014932 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 479435014933 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 479435014934 dimer interface [polypeptide binding]; other site 479435014935 motif 1; other site 479435014936 active site 479435014937 motif 2; other site 479435014938 motif 3; other site 479435014939 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 479435014940 putative active site [active] 479435014941 redox center [active] 479435014942 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435014943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014944 putative substrate translocation pore; other site 479435014945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435014946 tetracycline repressor protein TetR; Provisional; Region: PRK13756 479435014947 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014948 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435014949 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435014950 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 479435014951 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479435014952 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 479435014953 23S rRNA binding site [nucleotide binding]; other site 479435014954 L21 binding site [polypeptide binding]; other site 479435014955 L13 binding site [polypeptide binding]; other site 479435014956 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 479435014957 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 479435014958 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 479435014959 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 479435014960 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435014961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435014962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014963 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 479435014964 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479435014965 active site 479435014966 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435014967 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435014968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014969 dimer interface [polypeptide binding]; other site 479435014970 conserved gate region; other site 479435014971 putative PBP binding loops; other site 479435014972 ABC-ATPase subunit interface; other site 479435014973 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 479435014974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435014975 dimer interface [polypeptide binding]; other site 479435014976 conserved gate region; other site 479435014977 putative PBP binding loops; other site 479435014978 ABC-ATPase subunit interface; other site 479435014979 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435014980 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435014981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435014982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435014983 DNA binding site [nucleotide binding] 479435014984 domain linker motif; other site 479435014985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435014986 ligand binding site [chemical binding]; other site 479435014987 dimerization interface [polypeptide binding]; other site 479435014988 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435014989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435014990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435014991 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435014992 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435014993 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435014994 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435014995 Walker A/P-loop; other site 479435014996 ATP binding site [chemical binding]; other site 479435014997 Q-loop/lid; other site 479435014998 ABC transporter signature motif; other site 479435014999 Walker B; other site 479435015000 D-loop; other site 479435015001 H-loop/switch region; other site 479435015002 hypothetical protein; Provisional; Region: PRK06547 479435015003 AAA domain; Region: AAA_18; pfam13238 479435015004 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 479435015005 active site 479435015006 catalytic residues [active] 479435015007 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 479435015008 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 479435015009 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 479435015010 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 479435015011 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 479435015012 homodimer interface [polypeptide binding]; other site 479435015013 putative metal binding site [ion binding]; other site 479435015014 sec-independent translocase; Provisional; Region: PRK01371 479435015015 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479435015016 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 479435015017 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 479435015018 Putative zinc-finger; Region: zf-HC2; pfam13490 479435015019 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435015020 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015021 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435015022 DNA binding residues [nucleotide binding] 479435015023 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 479435015024 carboxyltransferase (CT) interaction site; other site 479435015025 biotinylation site [posttranslational modification]; other site 479435015026 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435015027 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435015028 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435015029 Coenzyme A binding pocket [chemical binding]; other site 479435015030 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479435015031 active site 479435015032 dimer interface [polypeptide binding]; other site 479435015033 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 479435015034 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435015035 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 479435015036 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479435015037 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 479435015038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015039 S-adenosylmethionine binding site [chemical binding]; other site 479435015040 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435015041 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 479435015042 Amidohydrolase; Region: Amidohydro_2; pfam04909 479435015043 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 479435015044 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435015045 homotrimer interaction site [polypeptide binding]; other site 479435015046 putative active site [active] 479435015047 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 479435015048 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 479435015049 NAD binding site [chemical binding]; other site 479435015050 catalytic residues [active] 479435015051 hypothetical protein; Provisional; Region: PRK06185 479435015052 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479435015053 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479435015054 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435015055 kynureninase; Region: kynureninase; TIGR01814 479435015056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435015057 catalytic residue [active] 479435015058 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 479435015059 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 479435015060 ligand binding site; other site 479435015061 oligomer interface; other site 479435015062 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 479435015063 dimer interface [polypeptide binding]; other site 479435015064 N-terminal domain interface [polypeptide binding]; other site 479435015065 sulfate 1 binding site; other site 479435015066 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435015067 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015068 Coenzyme A binding pocket [chemical binding]; other site 479435015069 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 479435015070 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 479435015071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435015072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435015073 active site 479435015074 catalytic tetrad [active] 479435015075 multifunctional aminopeptidase A; Provisional; Region: PRK00913 479435015076 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 479435015077 interface (dimer of trimers) [polypeptide binding]; other site 479435015078 Substrate-binding/catalytic site; other site 479435015079 Zn-binding sites [ion binding]; other site 479435015080 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 479435015081 PaaX-like protein; Region: PaaX; pfam07848 479435015082 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 479435015083 enoyl-CoA hydratase; Provisional; Region: PRK06688 479435015084 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 479435015085 substrate binding site [chemical binding]; other site 479435015086 oxyanion hole (OAH) forming residues; other site 479435015087 trimer interface [polypeptide binding]; other site 479435015088 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 479435015089 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 479435015090 DivIVA domain; Region: DivI1A_domain; TIGR03544 479435015091 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 479435015092 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 479435015093 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 479435015094 metal binding site [ion binding]; metal-binding site 479435015095 putative dimer interface [polypeptide binding]; other site 479435015096 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435015097 active site 479435015098 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479435015099 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435015100 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435015101 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 479435015102 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435015103 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435015104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435015105 dimer interface [polypeptide binding]; other site 479435015106 conserved gate region; other site 479435015107 putative PBP binding loops; other site 479435015108 ABC-ATPase subunit interface; other site 479435015109 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435015110 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435015111 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 479435015112 putative active site [active] 479435015113 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435015114 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 479435015115 substrate binding site [chemical binding]; other site 479435015116 dimer interface [polypeptide binding]; other site 479435015117 ATP binding site [chemical binding]; other site 479435015118 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435015119 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435015120 DNA binding site [nucleotide binding] 479435015121 domain linker motif; other site 479435015122 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435015123 ligand binding site [chemical binding]; other site 479435015124 dimerization interface [polypeptide binding]; other site 479435015125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015126 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 479435015127 NAD(P) binding site [chemical binding]; other site 479435015128 active site 479435015129 Phosphotransferase enzyme family; Region: APH; pfam01636 479435015130 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435015131 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 479435015132 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 479435015133 putative trimer interface [polypeptide binding]; other site 479435015134 putative CoA binding site [chemical binding]; other site 479435015135 Ferredoxin [Energy production and conversion]; Region: COG1146 479435015136 4Fe-4S binding domain; Region: Fer4; pfam00037 479435015137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015138 Coenzyme A binding pocket [chemical binding]; other site 479435015139 short chain dehydrogenase; Provisional; Region: PRK08219 479435015140 classical (c) SDRs; Region: SDR_c; cd05233 479435015141 NAD(P) binding site [chemical binding]; other site 479435015142 active site 479435015143 PemK-like protein; Region: PemK; pfam02452 479435015144 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 479435015145 VanW like protein; Region: VanW; pfam04294 479435015146 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 479435015147 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435015148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435015149 non-specific DNA binding site [nucleotide binding]; other site 479435015150 salt bridge; other site 479435015151 sequence-specific DNA binding site [nucleotide binding]; other site 479435015152 NB-ARC domain; Region: NB-ARC; pfam00931 479435015153 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435015155 binding surface 479435015156 TPR motif; other site 479435015157 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015158 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 479435015159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435015160 sequence-specific DNA binding site [nucleotide binding]; other site 479435015161 salt bridge; other site 479435015162 NB-ARC domain; Region: NB-ARC; pfam00931 479435015163 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 479435015164 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435015165 binding surface 479435015166 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015167 TPR motif; other site 479435015168 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015170 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435015171 binding surface 479435015172 TPR motif; other site 479435015173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435015175 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 479435015176 active site 479435015177 8-oxo-dGMP binding site [chemical binding]; other site 479435015178 nudix motif; other site 479435015179 metal binding site [ion binding]; metal-binding site 479435015180 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 479435015181 L-aspartate oxidase; Provisional; Region: PRK06175 479435015182 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 479435015183 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 479435015184 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435015185 catalytic loop [active] 479435015186 iron binding site [ion binding]; other site 479435015187 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 479435015188 ABC1 family; Region: ABC1; cl17513 479435015189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015190 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435015191 oxidoreductase; Provisional; Region: PRK12743 479435015192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015193 NAD(P) binding site [chemical binding]; other site 479435015194 active site 479435015195 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 479435015196 aromatic arch; other site 479435015197 DCoH dimer interaction site [polypeptide binding]; other site 479435015198 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 479435015199 DCoH tetramer interaction site [polypeptide binding]; other site 479435015200 substrate binding site [chemical binding]; other site 479435015201 Putative catalytic domain of uncharacterized bacterial hypothetical proteins similar to insect chitin deacetylase-like proteins; Region: CE4_CDA_like_3; cd10976 479435015202 NodB motif; other site 479435015203 putative active site [active] 479435015204 putative catalytic site [active] 479435015205 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 479435015206 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435015207 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435015208 Cytochrome P450; Region: p450; cl12078 479435015209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435015210 dimerization interface [polypeptide binding]; other site 479435015211 putative DNA binding site [nucleotide binding]; other site 479435015212 putative Zn2+ binding site [ion binding]; other site 479435015213 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 479435015214 putative hydrophobic ligand binding site [chemical binding]; other site 479435015215 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435015216 conserved cys residue [active] 479435015217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435015218 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435015219 AAA domain; Region: AAA_17; pfam13207 479435015220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435015221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015222 S-adenosylmethionine binding site [chemical binding]; other site 479435015223 HTH domain; Region: HTH_11; pfam08279 479435015224 WYL domain; Region: WYL; pfam13280 479435015225 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 479435015226 dimer interface [polypeptide binding]; other site 479435015227 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435015228 active site 479435015229 metal binding site [ion binding]; metal-binding site 479435015230 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 479435015231 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 479435015232 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 479435015233 catalytic residues [active] 479435015234 catalytic nucleophile [active] 479435015235 Recombinase; Region: Recombinase; pfam07508 479435015236 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 479435015237 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 479435015238 nucleotide binding site [chemical binding]; other site 479435015239 polymerase nucleotide-binding site; other site 479435015240 primase nucleotide-binding site [nucleotide binding]; other site 479435015241 DNA-binding residues [nucleotide binding]; DNA binding site 479435015242 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 479435015243 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435015244 non-specific DNA binding site [nucleotide binding]; other site 479435015245 salt bridge; other site 479435015246 sequence-specific DNA binding site [nucleotide binding]; other site 479435015247 HD domain; Region: HD_3; pfam13023 479435015248 GTP-binding protein YchF; Reviewed; Region: PRK09601 479435015249 YchF GTPase; Region: YchF; cd01900 479435015250 G1 box; other site 479435015251 GTP/Mg2+ binding site [chemical binding]; other site 479435015252 Switch I region; other site 479435015253 G2 box; other site 479435015254 Switch II region; other site 479435015255 G3 box; other site 479435015256 G4 box; other site 479435015257 G5 box; other site 479435015258 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 479435015259 Protein of unknown function (DUF817); Region: DUF817; pfam05675 479435015260 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 479435015261 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 479435015262 NodB motif; other site 479435015263 active site 479435015264 catalytic site [active] 479435015265 metal binding site [ion binding]; metal-binding site 479435015266 RmuC family; Region: RmuC; pfam02646 479435015267 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 479435015268 substrate binding pocket [chemical binding]; other site 479435015269 catalytic residues [active] 479435015270 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435015271 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015272 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435015273 DNA binding residues [nucleotide binding] 479435015274 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 479435015275 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 479435015276 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 479435015277 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 479435015278 generic binding surface II; other site 479435015279 generic binding surface I; other site 479435015280 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 479435015281 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435015282 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435015283 active site 479435015284 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015285 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 479435015286 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 479435015287 Phosphotransferase enzyme family; Region: APH; pfam01636 479435015288 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 479435015289 active site 479435015290 ATP binding site [chemical binding]; other site 479435015291 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 479435015292 Ligand binding site; other site 479435015293 metal-binding site 479435015294 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 479435015295 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 479435015296 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 479435015297 putative active site [active] 479435015298 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435015299 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 479435015300 putative substrate binding site [chemical binding]; other site 479435015301 putative ATP binding site [chemical binding]; other site 479435015302 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435015303 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 479435015304 fumarate hydratase; Provisional; Region: PRK15389 479435015305 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 479435015306 Fumarase C-terminus; Region: Fumerase_C; pfam05683 479435015307 Cupin; Region: Cupin_6; pfam12852 479435015308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435015309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435015310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435015311 short chain dehydrogenase; Provisional; Region: PRK06500 479435015312 classical (c) SDRs; Region: SDR_c; cd05233 479435015313 NAD(P) binding site [chemical binding]; other site 479435015314 active site 479435015315 Protein of unknown function (DUF402); Region: DUF402; pfam04167 479435015316 fumarate hydratase; Reviewed; Region: fumC; PRK00485 479435015317 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 479435015318 active sites [active] 479435015319 tetramer interface [polypeptide binding]; other site 479435015320 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 479435015321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435015322 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479435015323 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435015324 catalytic residue [active] 479435015325 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 479435015326 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 479435015327 putative active site [active] 479435015328 PhoH-like protein; Region: PhoH; pfam02562 479435015329 LabA_like proteins; Region: LabA_like; cd06167 479435015330 putative metal binding site [ion binding]; other site 479435015331 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 479435015332 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 479435015333 catalytic residue [active] 479435015334 putative FPP diphosphate binding site; other site 479435015335 putative FPP binding hydrophobic cleft; other site 479435015336 dimer interface [polypeptide binding]; other site 479435015337 putative IPP diphosphate binding site; other site 479435015338 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 479435015339 Haemolysin-III related; Region: HlyIII; pfam03006 479435015340 deazaflavin-dependent oxidoreductase, nitroreductase family; Region: hi_GC_TIGR00026 479435015341 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 479435015342 Peptidase family M28; Region: Peptidase_M28; pfam04389 479435015343 active site 479435015344 metal binding site [ion binding]; metal-binding site 479435015345 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435015346 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 479435015347 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 479435015348 active site 479435015349 Zn binding site [ion binding]; other site 479435015350 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 479435015351 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 479435015352 catalytic residues [active] 479435015353 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 479435015354 Copper resistance protein D; Region: CopD; pfam05425 479435015355 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 479435015356 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 479435015357 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 479435015358 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 479435015359 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 479435015360 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 479435015361 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435015362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435015363 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435015364 Walker A/P-loop; other site 479435015365 ATP binding site [chemical binding]; other site 479435015366 Q-loop/lid; other site 479435015367 ABC transporter signature motif; other site 479435015368 Walker B; other site 479435015369 D-loop; other site 479435015370 H-loop/switch region; other site 479435015371 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435015372 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435015373 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435015374 active site 479435015375 ATP binding site [chemical binding]; other site 479435015376 substrate binding site [chemical binding]; other site 479435015377 activation loop (A-loop); other site 479435015378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015379 putative substrate translocation pore; other site 479435015380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435015382 MarR family; Region: MarR; pfam01047 479435015383 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435015384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435015385 dimer interface [polypeptide binding]; other site 479435015386 conserved gate region; other site 479435015387 putative PBP binding loops; other site 479435015388 ABC-ATPase subunit interface; other site 479435015389 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 479435015390 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435015391 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435015392 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435015393 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435015394 threonine dehydratase; Provisional; Region: PRK08198 479435015395 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435015396 tetramer interface [polypeptide binding]; other site 479435015397 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015398 catalytic residue [active] 479435015399 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 479435015400 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435015401 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435015402 active site 479435015403 catalytic tetrad [active] 479435015404 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435015405 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435015406 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435015407 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435015408 nodulation ABC transporter NodI; Provisional; Region: PRK13537 479435015409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435015410 Walker A/P-loop; other site 479435015411 ATP binding site [chemical binding]; other site 479435015412 Q-loop/lid; other site 479435015413 ABC transporter signature motif; other site 479435015414 Walker B; other site 479435015415 D-loop; other site 479435015416 H-loop/switch region; other site 479435015417 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 479435015418 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 479435015419 classical (c) SDRs; Region: SDR_c; cd05233 479435015420 NAD(P) binding site [chemical binding]; other site 479435015421 active site 479435015422 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435015423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435015424 putative DNA binding site [nucleotide binding]; other site 479435015425 putative Zn2+ binding site [ion binding]; other site 479435015426 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435015427 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015428 putative substrate translocation pore; other site 479435015429 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435015430 Hemerythrin-like domain; Region: Hr-like; cd12108 479435015431 Fe binding site [ion binding]; other site 479435015432 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 479435015433 Domain of unknown function DUF20; Region: UPF0118; pfam01594 479435015434 MutL protein; Region: MutL; pfam13941 479435015435 cystathionine gamma-synthase; Provisional; Region: PRK07811 479435015436 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 479435015437 homodimer interface [polypeptide binding]; other site 479435015438 substrate-cofactor binding pocket; other site 479435015439 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015440 catalytic residue [active] 479435015441 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015442 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015443 MMPL family; Region: MMPL; pfam03176 479435015444 MMPL family; Region: MMPL; pfam03176 479435015445 Predicted membrane protein [Function unknown]; Region: COG2364 479435015446 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 479435015447 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435015448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435015449 DNA-binding site [nucleotide binding]; DNA binding site 479435015450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435015451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015452 homodimer interface [polypeptide binding]; other site 479435015453 catalytic residue [active] 479435015454 methionine sulfoxide reductase A; Provisional; Region: PRK00058 479435015455 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 479435015456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435015457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015458 S-adenosylmethionine binding site [chemical binding]; other site 479435015459 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435015460 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435015461 active site 479435015462 NTP binding site [chemical binding]; other site 479435015463 metal binding triad [ion binding]; metal-binding site 479435015464 antibiotic binding site [chemical binding]; other site 479435015465 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435015466 DinB superfamily; Region: DinB_2; pfam12867 479435015467 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 479435015468 Protein of unknown function DUF99; Region: DUF99; cl00704 479435015469 DinB superfamily; Region: DinB_2; pfam12867 479435015470 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435015471 DinB superfamily; Region: DinB_2; pfam12867 479435015472 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435015473 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015474 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435015475 Coenzyme A binding pocket [chemical binding]; other site 479435015476 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 479435015477 nucleotide binding site/active site [active] 479435015478 HIT family signature motif; other site 479435015479 catalytic residue [active] 479435015480 Catalytic domain, repeat 1, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_1; cd09104 479435015481 putative active site [active] 479435015482 catalytic site [active] 479435015483 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 479435015484 PLD-like domain; Region: PLDc_2; pfam13091 479435015485 putative active site [active] 479435015486 catalytic site [active] 479435015487 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435015488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435015489 DNA binding site [nucleotide binding] 479435015490 domain linker motif; other site 479435015491 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435015492 dimerization interface [polypeptide binding]; other site 479435015493 ligand binding site [chemical binding]; other site 479435015494 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 479435015495 short chain dehydrogenase; Provisional; Region: PRK12747 479435015496 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 479435015497 NADP binding site [chemical binding]; other site 479435015498 homodimer interface [polypeptide binding]; other site 479435015499 active site 479435015500 substrate binding site [chemical binding]; other site 479435015501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015503 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 479435015504 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 479435015505 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 479435015506 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 479435015507 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 479435015508 dimer interface [polypeptide binding]; other site 479435015509 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015510 catalytic residue [active] 479435015511 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 479435015512 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 479435015513 active site 479435015514 catalytic triad [active] 479435015515 oxyanion hole [active] 479435015516 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 479435015517 Bax inhibitor 1 like; Region: BaxI_1; cl17691 479435015518 Cupin domain; Region: Cupin_2; pfam07883 479435015519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015520 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435015521 NAD(P) binding site [chemical binding]; other site 479435015522 active site 479435015523 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 479435015524 heme bH binding site [chemical binding]; other site 479435015525 intrachain domain interface; other site 479435015526 heme bL binding site [chemical binding]; other site 479435015527 interchain domain interface [polypeptide binding]; other site 479435015528 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 479435015529 Qo binding site; other site 479435015530 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435015531 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435015532 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 479435015533 active site 479435015534 catalytic residues [active] 479435015535 metal binding site [ion binding]; metal-binding site 479435015536 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435015537 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 479435015538 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 479435015539 Histidine kinase; Region: HisKA_3; pfam07730 479435015540 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435015541 ATP binding site [chemical binding]; other site 479435015542 Mg2+ binding site [ion binding]; other site 479435015543 G-X-G motif; other site 479435015544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435015545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435015546 active site 479435015547 phosphorylation site [posttranslational modification] 479435015548 intermolecular recognition site; other site 479435015549 dimerization interface [polypeptide binding]; other site 479435015550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435015551 dimerization interface [polypeptide binding]; other site 479435015552 DNA binding residues [nucleotide binding] 479435015553 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 479435015554 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 479435015555 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 479435015556 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435015557 Cupin domain; Region: Cupin_2; pfam07883 479435015558 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 479435015559 Fe-S cluster binding site [ion binding]; other site 479435015560 DNA binding site [nucleotide binding] 479435015561 active site 479435015562 exopolyphosphatase; Region: exo_poly_only; TIGR03706 479435015563 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 479435015564 Protein of unknown function (DUF501); Region: DUF501; pfam04417 479435015565 Septum formation initiator; Region: DivIC; pfam04977 479435015566 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 479435015567 enolase; Provisional; Region: eno; PRK00077 479435015568 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 479435015569 dimer interface [polypeptide binding]; other site 479435015570 metal binding site [ion binding]; metal-binding site 479435015571 substrate binding pocket [chemical binding]; other site 479435015572 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 479435015573 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 479435015574 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 479435015575 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 479435015576 homodimer interface [polypeptide binding]; other site 479435015577 metal binding site [ion binding]; metal-binding site 479435015578 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 479435015579 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 479435015580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435015581 ATP binding site [chemical binding]; other site 479435015582 putative Mg++ binding site [ion binding]; other site 479435015583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435015584 nucleotide binding region [chemical binding]; other site 479435015585 ATP-binding site [chemical binding]; other site 479435015586 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 479435015587 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 479435015588 putative active site [active] 479435015589 catalytic residue [active] 479435015590 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 479435015591 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 479435015592 5S rRNA interface [nucleotide binding]; other site 479435015593 CTC domain interface [polypeptide binding]; other site 479435015594 L16 interface [polypeptide binding]; other site 479435015595 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435015596 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 479435015597 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 479435015598 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 479435015599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435015600 active site 479435015601 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 479435015602 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 479435015603 Substrate binding site; other site 479435015604 Mg++ binding site; other site 479435015605 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 479435015606 active site 479435015607 substrate binding site [chemical binding]; other site 479435015608 CoA binding site [chemical binding]; other site 479435015609 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 479435015610 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435015611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435015612 active site 479435015613 phosphorylation site [posttranslational modification] 479435015614 intermolecular recognition site; other site 479435015615 dimerization interface [polypeptide binding]; other site 479435015616 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435015617 DNA binding residues [nucleotide binding] 479435015618 dimerization interface [polypeptide binding]; other site 479435015619 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435015620 Histidine kinase; Region: HisKA_3; pfam07730 479435015621 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 479435015622 ATP binding site [chemical binding]; other site 479435015623 Mg2+ binding site [ion binding]; other site 479435015624 G-X-G motif; other site 479435015625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015627 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 479435015628 Fatty acid desaturase; Region: FA_desaturase; pfam00487 479435015629 Di-iron ligands [ion binding]; other site 479435015630 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 479435015631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435015632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435015633 Walker A/P-loop; other site 479435015634 ATP binding site [chemical binding]; other site 479435015635 Q-loop/lid; other site 479435015636 ABC transporter signature motif; other site 479435015637 Walker B; other site 479435015638 D-loop; other site 479435015639 H-loop/switch region; other site 479435015640 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435015641 FtsX-like permease family; Region: FtsX; pfam02687 479435015642 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435015643 FtsX-like permease family; Region: FtsX; pfam02687 479435015644 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 479435015645 active site 479435015646 metal binding site [ion binding]; metal-binding site 479435015647 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 479435015648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015649 S-adenosylmethionine binding site [chemical binding]; other site 479435015650 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435015651 MarR family; Region: MarR_2; cl17246 479435015652 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435015653 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435015654 ABC transporter; Region: ABC_tran_2; pfam12848 479435015655 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435015656 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435015657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015658 S-adenosylmethionine binding site [chemical binding]; other site 479435015659 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 479435015660 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 479435015661 G1 box; other site 479435015662 putative GEF interaction site [polypeptide binding]; other site 479435015663 GTP/Mg2+ binding site [chemical binding]; other site 479435015664 Switch I region; other site 479435015665 G2 box; other site 479435015666 G3 box; other site 479435015667 Switch II region; other site 479435015668 G4 box; other site 479435015669 G5 box; other site 479435015670 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 479435015671 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 479435015672 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 479435015673 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 479435015674 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435015675 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015676 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435015677 DNA binding residues [nucleotide binding] 479435015678 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 479435015679 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 479435015680 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 479435015681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015682 S-adenosylmethionine binding site [chemical binding]; other site 479435015683 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479435015684 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479435015685 Domain of unknown function (DUF348); Region: DUF348; pfam03990 479435015686 G5 domain; Region: G5; pfam07501 479435015687 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 479435015688 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 479435015689 FMN binding site [chemical binding]; other site 479435015690 dimer interface [polypeptide binding]; other site 479435015691 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 479435015692 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 479435015693 active site 479435015694 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 479435015695 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 479435015696 active site 479435015697 HIGH motif; other site 479435015698 KMSKS motif; other site 479435015699 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 479435015700 tRNA binding surface [nucleotide binding]; other site 479435015701 anticodon binding site; other site 479435015702 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 479435015703 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 479435015704 active site 479435015705 HIGH motif; other site 479435015706 KMSKS motif; other site 479435015707 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 479435015708 tRNA binding surface [nucleotide binding]; other site 479435015709 anticodon binding site; other site 479435015710 Predicted methyltransferases [General function prediction only]; Region: COG0313 479435015711 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 479435015712 putative SAM binding site [chemical binding]; other site 479435015713 putative homodimer interface [polypeptide binding]; other site 479435015714 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 479435015715 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435015716 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 479435015717 Domain of unknown function (DUF364); Region: DUF364; pfam04016 479435015718 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435015719 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 479435015720 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435015721 catalytic residue [active] 479435015722 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 479435015723 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435015724 Walker A/P-loop; other site 479435015725 ATP binding site [chemical binding]; other site 479435015726 Q-loop/lid; other site 479435015727 ABC transporter signature motif; other site 479435015728 Walker B; other site 479435015729 D-loop; other site 479435015730 H-loop/switch region; other site 479435015731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 479435015732 Walker A/P-loop; other site 479435015733 ATP binding site [chemical binding]; other site 479435015734 Q-loop/lid; other site 479435015735 ABC transporter signature motif; other site 479435015736 Walker B; other site 479435015737 D-loop; other site 479435015738 H-loop/switch region; other site 479435015739 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 479435015740 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 479435015741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435015742 dimer interface [polypeptide binding]; other site 479435015743 conserved gate region; other site 479435015744 putative PBP binding loops; other site 479435015745 ABC-ATPase subunit interface; other site 479435015746 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 479435015747 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 479435015748 Fructosamine kinase; Region: Fructosamin_kin; cl17579 479435015749 Phosphotransferase enzyme family; Region: APH; pfam01636 479435015750 Predicted flavoprotein [General function prediction only]; Region: COG0431 479435015751 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435015752 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435015753 MarR family; Region: MarR_2; pfam12802 479435015754 Copper resistance protein D; Region: CopD; pfam05425 479435015755 CopC domain; Region: CopC; pfam04234 479435015756 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 479435015757 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435015758 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 479435015759 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 479435015760 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435015761 anti sigma factor interaction site; other site 479435015762 regulatory phosphorylation site [posttranslational modification]; other site 479435015763 MMPL family; Region: MMPL; pfam03176 479435015764 Histidine kinase; Region: HisKA_3; pfam07730 479435015765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435015766 ATP binding site [chemical binding]; other site 479435015767 Mg2+ binding site [ion binding]; other site 479435015768 G-X-G motif; other site 479435015769 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435015770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435015771 active site 479435015772 phosphorylation site [posttranslational modification] 479435015773 intermolecular recognition site; other site 479435015774 dimerization interface [polypeptide binding]; other site 479435015775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435015776 DNA binding residues [nucleotide binding] 479435015777 dimerization interface [polypeptide binding]; other site 479435015778 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435015779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435015780 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 479435015781 MPT binding site; other site 479435015782 trimer interface [polypeptide binding]; other site 479435015783 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 479435015784 trimer interface [polypeptide binding]; other site 479435015785 dimer interface [polypeptide binding]; other site 479435015786 putative active site [active] 479435015787 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 479435015788 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 479435015789 dimer interface [polypeptide binding]; other site 479435015790 putative functional site; other site 479435015791 putative MPT binding site; other site 479435015792 putative acetyltransferase; Provisional; Region: PRK03624 479435015793 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015794 Coenzyme A binding pocket [chemical binding]; other site 479435015795 Eukaryotic UGPase catalyses the synthesis of UDP-Glucose; Region: UGPase_euk; cd00897 479435015796 active site 479435015797 substrate binding site; other site 479435015798 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 479435015799 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 479435015800 Phosphotransferase enzyme family; Region: APH; pfam01636 479435015801 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435015802 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 479435015803 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 479435015804 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 479435015805 active site 479435015806 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 479435015807 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 479435015808 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 479435015809 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 479435015810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015811 Coenzyme A binding pocket [chemical binding]; other site 479435015812 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435015813 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435015814 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435015815 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015816 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435015817 META domain; Region: META; cl01245 479435015818 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 479435015819 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 479435015820 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435015821 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435015822 putative sugar binding sites [chemical binding]; other site 479435015823 Q-X-W motif; other site 479435015824 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435015825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435015826 active site 479435015827 phosphorylation site [posttranslational modification] 479435015828 intermolecular recognition site; other site 479435015829 dimerization interface [polypeptide binding]; other site 479435015830 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435015831 DNA binding site [nucleotide binding] 479435015832 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435015833 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435015834 dimerization interface [polypeptide binding]; other site 479435015835 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 479435015836 dimer interface [polypeptide binding]; other site 479435015837 phosphorylation site [posttranslational modification] 479435015838 YCII-related domain; Region: YCII; cl00999 479435015839 hypothetical protein; Provisional; Region: PRK01842 479435015840 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435015841 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435015842 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435015843 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435015844 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435015845 active site 479435015846 metal binding site [ion binding]; metal-binding site 479435015847 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 479435015848 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435015849 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435015850 conserved cys residue [active] 479435015851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435015852 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435015853 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479435015854 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435015855 ANTAR domain; Region: ANTAR; pfam03861 479435015856 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 479435015857 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435015858 ANTAR domain; Region: ANTAR; pfam03861 479435015859 FOG: CBS domain [General function prediction only]; Region: COG0517 479435015860 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 479435015861 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435015862 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 479435015863 sugar binding site [chemical binding]; other site 479435015864 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435015865 CARDB; Region: CARDB; pfam07705 479435015866 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435015867 putative metal binding site [ion binding]; other site 479435015868 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435015869 Right handed beta helix region; Region: Beta_helix; pfam13229 479435015870 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 479435015871 RibD C-terminal domain; Region: RibD_C; cl17279 479435015872 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 479435015873 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435015874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015875 S-adenosylmethionine binding site [chemical binding]; other site 479435015876 short chain dehydrogenase; Provisional; Region: PRK05854 479435015877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435015878 NAD(P) binding site [chemical binding]; other site 479435015879 active site 479435015880 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015881 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015882 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 479435015883 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435015884 AAA ATPase domain; Region: AAA_16; pfam13191 479435015885 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435015886 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435015887 DNA binding residues [nucleotide binding] 479435015888 dimerization interface [polypeptide binding]; other site 479435015889 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435015890 Coenzyme A binding pocket [chemical binding]; other site 479435015891 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 479435015892 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 479435015893 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 479435015894 substrate binding pocket [chemical binding]; other site 479435015895 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 479435015896 B12 binding site [chemical binding]; other site 479435015897 cobalt ligand [ion binding]; other site 479435015898 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 479435015899 WYL domain; Region: WYL; pfam13280 479435015900 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435015901 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435015902 Domain of unknown function (DUF385); Region: DUF385; pfam04075 479435015903 ribonuclease Z; Reviewed; Region: PRK00055 479435015904 hypothetical protein; Provisional; Region: PRK06815 479435015905 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 479435015906 tetramer interface [polypeptide binding]; other site 479435015907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435015908 catalytic residue [active] 479435015909 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 479435015910 active site 479435015911 catalytic triad [active] 479435015912 oxyanion hole [active] 479435015913 glycyl-tRNA synthetase; Provisional; Region: PRK14908 479435015914 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 479435015915 motif 1; other site 479435015916 dimer interface [polypeptide binding]; other site 479435015917 active site 479435015918 motif 2; other site 479435015919 motif 3; other site 479435015920 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 479435015921 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 479435015922 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 479435015923 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435015924 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 479435015925 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435015926 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435015927 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435015928 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435015929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 479435015930 Transcriptional regulator [Transcription]; Region: LytR; COG1316 479435015931 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435015932 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435015933 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435015934 Walker A/P-loop; other site 479435015935 ATP binding site [chemical binding]; other site 479435015936 Q-loop/lid; other site 479435015937 ABC transporter signature motif; other site 479435015938 Walker B; other site 479435015939 D-loop; other site 479435015940 H-loop/switch region; other site 479435015941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015943 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435015944 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435015945 classical (c) SDRs; Region: SDR_c; cd05233 479435015946 NAD(P) binding site [chemical binding]; other site 479435015947 active site 479435015948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435015949 S-adenosylmethionine binding site [chemical binding]; other site 479435015950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435015951 DNA-binding site [nucleotide binding]; DNA binding site 479435015952 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435015953 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435015954 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435015955 hypothetical protein; Provisional; Region: PRK07236 479435015956 hypothetical protein; Provisional; Region: PRK07588 479435015957 TIGR03086 family protein; Region: TIGR03086 479435015958 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435015959 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 479435015960 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435015961 FecCD transport family; Region: FecCD; pfam01032 479435015962 dimer interface [polypeptide binding]; other site 479435015963 putative PBP binding regions; other site 479435015964 ABC-ATPase subunit interface; other site 479435015965 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435015966 ABC-ATPase subunit interface; other site 479435015967 dimer interface [polypeptide binding]; other site 479435015968 putative PBP binding regions; other site 479435015969 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 479435015970 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 479435015971 siderophore binding site; other site 479435015972 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435015973 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435015974 Walker A/P-loop; other site 479435015975 ATP binding site [chemical binding]; other site 479435015976 Q-loop/lid; other site 479435015977 ABC transporter signature motif; other site 479435015978 Walker B; other site 479435015979 D-loop; other site 479435015980 H-loop/switch region; other site 479435015981 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 479435015982 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 479435015983 active site 479435015984 FMN binding site [chemical binding]; other site 479435015985 2,4-decadienoyl-CoA binding site; other site 479435015986 catalytic residue [active] 479435015987 4Fe-4S cluster binding site [ion binding]; other site 479435015988 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 479435015989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 479435015990 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435015991 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435015992 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 479435015993 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 479435015994 TrkA-C domain; Region: TrkA_C; pfam02080 479435015995 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 479435015996 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 479435015997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 479435015998 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 479435015999 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 479435016000 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 479435016001 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 479435016002 DNA binding site [nucleotide binding] 479435016003 active site 479435016004 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435016005 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435016006 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 479435016007 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 479435016008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435016009 AlkA N-terminal domain; Region: AlkA_N; pfam06029 479435016010 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 479435016011 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479435016012 minor groove reading motif; other site 479435016013 helix-hairpin-helix signature motif; other site 479435016014 substrate binding pocket [chemical binding]; other site 479435016015 active site 479435016016 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435016017 classical (c) SDRs; Region: SDR_c; cd05233 479435016018 NAD(P) binding site [chemical binding]; other site 479435016019 active site 479435016020 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435016021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435016022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435016023 DNA binding site [nucleotide binding] 479435016024 domain linker motif; other site 479435016025 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 479435016026 ligand binding site [chemical binding]; other site 479435016027 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 479435016028 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435016029 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 479435016030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435016031 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435016032 Walker A/P-loop; other site 479435016033 ATP binding site [chemical binding]; other site 479435016034 Q-loop/lid; other site 479435016035 ABC transporter signature motif; other site 479435016036 Walker B; other site 479435016037 D-loop; other site 479435016038 H-loop/switch region; other site 479435016039 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435016040 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435016041 Walker A/P-loop; other site 479435016042 ATP binding site [chemical binding]; other site 479435016043 Q-loop/lid; other site 479435016044 ABC transporter signature motif; other site 479435016045 Walker B; other site 479435016046 D-loop; other site 479435016047 H-loop/switch region; other site 479435016048 Predicted transcriptional regulators [Transcription]; Region: COG1725 479435016049 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016050 DNA-binding site [nucleotide binding]; DNA binding site 479435016051 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 479435016052 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 479435016053 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 479435016054 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 479435016055 Aminotransferase class IV; Region: Aminotran_4; pfam01063 479435016056 substrate-cofactor binding pocket; other site 479435016057 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 479435016058 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 479435016059 chorismate binding enzyme; Region: Chorismate_bind; cl10555 479435016060 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435016061 S-adenosylmethionine binding site [chemical binding]; other site 479435016062 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 479435016063 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 479435016064 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 479435016065 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 479435016066 DNA photolyase; Region: DNA_photolyase; pfam00875 479435016067 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435016068 DNA-binding site [nucleotide binding]; DNA binding site 479435016069 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 479435016070 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435016071 Walker A/P-loop; other site 479435016072 ATP binding site [chemical binding]; other site 479435016073 Q-loop/lid; other site 479435016074 ABC transporter signature motif; other site 479435016075 Walker B; other site 479435016076 D-loop; other site 479435016077 H-loop/switch region; other site 479435016078 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 479435016079 intersubunit interface [polypeptide binding]; other site 479435016080 active site 479435016081 zinc binding site [ion binding]; other site 479435016082 Na+ binding site [ion binding]; other site 479435016083 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 479435016084 putative substrate binding site [chemical binding]; other site 479435016085 putative ATP binding site [chemical binding]; other site 479435016086 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 479435016087 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 479435016088 active site 479435016089 dimer interface [polypeptide binding]; other site 479435016090 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435016091 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435016092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016093 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 479435016094 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 479435016095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435016096 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435016097 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435016098 SPFH domain / Band 7 family; Region: Band_7; pfam01145 479435016099 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016100 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435016101 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 479435016102 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 479435016103 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479435016104 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 479435016105 citrate synthase 2; Provisional; Region: PRK12350 479435016106 Citrate synthase; Region: Citrate_synt; pfam00285 479435016107 oxalacetate binding site [chemical binding]; other site 479435016108 citrylCoA binding site [chemical binding]; other site 479435016109 coenzyme A binding site [chemical binding]; other site 479435016110 catalytic triad [active] 479435016111 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435016112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435016113 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435016114 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 479435016115 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 479435016116 hydrophobic ligand binding site; other site 479435016117 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435016118 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435016119 catalytic residue [active] 479435016120 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 479435016121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435016122 S-adenosylmethionine binding site [chemical binding]; other site 479435016123 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435016124 dimerization interface [polypeptide binding]; other site 479435016125 putative DNA binding site [nucleotide binding]; other site 479435016126 Predicted transcriptional regulator [Transcription]; Region: COG2345 479435016127 putative Zn2+ binding site [ion binding]; other site 479435016128 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435016129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016130 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 479435016131 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 479435016132 trimer interface [polypeptide binding]; other site 479435016133 active site 479435016134 substrate binding site [chemical binding]; other site 479435016135 CoA binding site [chemical binding]; other site 479435016136 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435016137 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435016138 DNA binding site [nucleotide binding] 479435016139 domain linker motif; other site 479435016140 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435016141 dimerization interface [polypeptide binding]; other site 479435016142 ligand binding site [chemical binding]; other site 479435016143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435016144 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435016145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435016146 dimer interface [polypeptide binding]; other site 479435016147 conserved gate region; other site 479435016148 putative PBP binding loops; other site 479435016149 ABC-ATPase subunit interface; other site 479435016150 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435016151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435016152 dimer interface [polypeptide binding]; other site 479435016153 conserved gate region; other site 479435016154 putative PBP binding loops; other site 479435016155 ABC-ATPase subunit interface; other site 479435016156 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 479435016157 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 479435016158 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 479435016159 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435016160 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435016161 mycothione reductase; Reviewed; Region: PRK07846 479435016162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435016163 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435016164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 479435016165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016166 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435016167 putative substrate translocation pore; other site 479435016168 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435016169 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435016170 putative Zn2+ binding site [ion binding]; other site 479435016171 putative DNA binding site [nucleotide binding]; other site 479435016172 dimerization interface [polypeptide binding]; other site 479435016173 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 479435016174 dimer interface [polypeptide binding]; other site 479435016175 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435016176 ligand binding site [chemical binding]; other site 479435016177 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 479435016178 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435016179 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 479435016180 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 479435016181 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435016182 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 479435016183 DNA-binding site [nucleotide binding]; DNA binding site 479435016184 RNA-binding motif; other site 479435016185 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 479435016186 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 479435016187 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 479435016188 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 479435016189 Ligand Binding Site [chemical binding]; other site 479435016190 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016192 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 479435016193 active site 479435016194 diiron metal binding site [ion binding]; other site 479435016195 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435016196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435016198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435016199 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435016200 dimerization interface [polypeptide binding]; other site 479435016201 substrate binding pocket [chemical binding]; other site 479435016202 Restriction endonuclease; Region: Mrr_cat; pfam04471 479435016203 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 479435016204 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 479435016205 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 479435016206 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435016207 active site 479435016208 metal binding site [ion binding]; metal-binding site 479435016209 Domain of unknown function (DUF427); Region: DUF427; cl00998 479435016210 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016212 Coenzyme A binding pocket [chemical binding]; other site 479435016213 hypothetical protein; Provisional; Region: PRK06762 479435016214 AAA domain; Region: AAA_33; pfam13671 479435016215 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 479435016216 WYL domain; Region: WYL; pfam13280 479435016217 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 479435016218 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435016219 nudix motif; other site 479435016220 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 479435016221 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 479435016222 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435016223 ATP binding site [chemical binding]; other site 479435016224 putative Mg++ binding site [ion binding]; other site 479435016225 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435016226 nucleotide binding region [chemical binding]; other site 479435016227 ATP-binding site [chemical binding]; other site 479435016228 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 479435016229 Ligand binding site; other site 479435016230 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 479435016231 active site 479435016232 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435016233 Part of AAA domain; Region: AAA_19; pfam13245 479435016234 Family description; Region: UvrD_C_2; pfam13538 479435016235 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435016236 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435016237 dimerization interface [polypeptide binding]; other site 479435016238 putative DNA binding site [nucleotide binding]; other site 479435016239 putative Zn2+ binding site [ion binding]; other site 479435016240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 479435016241 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 479435016242 PQQ-like domain; Region: PQQ_2; pfam13360 479435016243 Trp docking motif [polypeptide binding]; other site 479435016244 active site 479435016245 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435016246 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435016247 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 479435016248 PQQ-like domain; Region: PQQ_2; pfam13360 479435016249 elongation factor Tu; Reviewed; Region: PRK12736 479435016250 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 479435016251 G1 box; other site 479435016252 GEF interaction site [polypeptide binding]; other site 479435016253 GTP/Mg2+ binding site [chemical binding]; other site 479435016254 Switch I region; other site 479435016255 G2 box; other site 479435016256 G3 box; other site 479435016257 Switch II region; other site 479435016258 G4 box; other site 479435016259 G5 box; other site 479435016260 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 479435016261 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 479435016262 Antibiotic Binding Site [chemical binding]; other site 479435016263 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 479435016264 CutC family; Region: CutC; cl01218 479435016265 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435016266 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435016267 DNA binding site [nucleotide binding] 479435016268 domain linker motif; other site 479435016269 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435016270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435016271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435016272 active site 479435016273 catalytic tetrad [active] 479435016274 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 479435016275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016276 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 479435016277 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 479435016278 Multicopper oxidase; Region: Cu-oxidase; pfam00394 479435016279 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 479435016280 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 479435016281 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435016282 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435016283 active site 479435016284 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435016285 dimerization interface [polypeptide binding]; other site 479435016286 putative DNA binding site [nucleotide binding]; other site 479435016287 putative Zn2+ binding site [ion binding]; other site 479435016288 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 479435016289 putative hydrophobic ligand binding site [chemical binding]; other site 479435016290 RibD C-terminal domain; Region: RibD_C; cl17279 479435016291 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435016292 putative catalytic site [active] 479435016293 putative metal binding site [ion binding]; other site 479435016294 putative phosphate binding site [ion binding]; other site 479435016295 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 479435016296 dimer interface [polypeptide binding]; other site 479435016297 putative active site [active] 479435016298 thymidylate synthase; Reviewed; Region: thyA; PRK01827 479435016299 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 479435016300 dimerization interface [polypeptide binding]; other site 479435016301 active site 479435016302 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435016303 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 479435016304 folate binding site [chemical binding]; other site 479435016305 NADP+ binding site [chemical binding]; other site 479435016306 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 479435016307 stage V sporulation protein K; Region: spore_V_K; TIGR02881 479435016308 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435016309 Walker A motif; other site 479435016310 ATP binding site [chemical binding]; other site 479435016311 Walker B motif; other site 479435016312 arginine finger; other site 479435016313 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 479435016314 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 479435016315 substrate binding pocket [chemical binding]; other site 479435016316 membrane-bound complex binding site; other site 479435016317 hinge residues; other site 479435016318 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435016319 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435016320 active site 479435016321 ATP binding site [chemical binding]; other site 479435016322 substrate binding site [chemical binding]; other site 479435016323 activation loop (A-loop); other site 479435016324 Double zinc ribbon; Region: DZR; pfam12773 479435016325 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 479435016326 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 479435016327 metal ion-dependent adhesion site (MIDAS); other site 479435016328 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 479435016329 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 479435016330 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 479435016331 phosphopeptide binding site; other site 479435016332 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435016333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016334 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 479435016335 Catalytic site [active] 479435016336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435016337 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 479435016338 Walker A/P-loop; other site 479435016339 ATP binding site [chemical binding]; other site 479435016340 Q-loop/lid; other site 479435016341 ABC transporter signature motif; other site 479435016342 Walker B; other site 479435016343 D-loop; other site 479435016344 H-loop/switch region; other site 479435016345 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435016346 DinB superfamily; Region: DinB_2; pfam12867 479435016347 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 479435016348 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 479435016349 ring oligomerisation interface [polypeptide binding]; other site 479435016350 ATP/Mg binding site [chemical binding]; other site 479435016351 stacking interactions; other site 479435016352 hinge regions; other site 479435016353 Protein of unknown function (DUF419); Region: DUF419; pfam04237 479435016354 PspC domain; Region: PspC; pfam04024 479435016355 Peptidase family M48; Region: Peptidase_M48; cl12018 479435016356 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 479435016357 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435016358 active site 479435016359 catalytic site [active] 479435016360 Protein of unknown function (DUF418); Region: DUF418; cl12135 479435016361 Protein of unknown function (DUF418); Region: DUF418; pfam04235 479435016362 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435016363 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435016364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435016365 Q-loop/lid; other site 479435016366 ABC transporter signature motif; other site 479435016367 Walker B; other site 479435016368 D-loop; other site 479435016369 H-loop/switch region; other site 479435016370 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435016371 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435016372 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435016373 Walker A/P-loop; other site 479435016374 ATP binding site [chemical binding]; other site 479435016375 Q-loop/lid; other site 479435016376 ABC transporter signature motif; other site 479435016377 Walker B; other site 479435016378 D-loop; other site 479435016379 H-loop/switch region; other site 479435016380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435016381 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 479435016382 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 479435016383 putative active site [active] 479435016384 putative metal binding site [ion binding]; other site 479435016385 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435016386 active site 479435016387 Radical SAM superfamily; Region: Radical_SAM; pfam04055 479435016388 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435016389 FeS/SAM binding site; other site 479435016390 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435016391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435016392 NAD(P) binding site [chemical binding]; other site 479435016393 active site 479435016394 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016396 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435016397 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435016398 putative catalytic site [active] 479435016399 putative metal binding site [ion binding]; other site 479435016400 putative phosphate binding site [ion binding]; other site 479435016401 HSP90 family protein; Provisional; Region: PRK14083 479435016402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435016403 ATP binding site [chemical binding]; other site 479435016404 Mg2+ binding site [ion binding]; other site 479435016405 G-X-G motif; other site 479435016406 Chloramphenicol phosphotransferase-like protein; Region: CPT; pfam07931 479435016407 P-loop motif; other site 479435016408 ATP binding site [chemical binding]; other site 479435016409 Chloramphenicol (Cm) binding site [chemical binding]; other site 479435016410 catalytic residue [active] 479435016411 GMP synthase; Reviewed; Region: guaA; PRK00074 479435016412 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 479435016413 AMP/PPi binding site [chemical binding]; other site 479435016414 candidate oxyanion hole; other site 479435016415 catalytic triad [active] 479435016416 potential glutamine specificity residues [chemical binding]; other site 479435016417 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 479435016418 ATP Binding subdomain [chemical binding]; other site 479435016419 Ligand Binding sites [chemical binding]; other site 479435016420 Dimerization subdomain; other site 479435016421 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 479435016422 AAA domain; Region: AAA_26; pfam13500 479435016423 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 479435016424 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435016425 catalytic residue [active] 479435016426 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479435016427 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 479435016428 inhibitor-cofactor binding pocket; inhibition site 479435016429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016430 catalytic residue [active] 479435016431 Zeta toxin; Region: Zeta_toxin; pfam06414 479435016432 biotin synthase; Validated; Region: PRK06256 479435016433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435016434 FeS/SAM binding site; other site 479435016435 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 479435016436 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 479435016437 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; cl17639 479435016438 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479435016439 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479435016440 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 479435016441 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 479435016442 NAD(P) binding site [chemical binding]; other site 479435016443 catalytic residues [active] 479435016444 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435016445 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 479435016446 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 479435016447 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 479435016448 active site 479435016449 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 479435016450 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479435016451 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 479435016452 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 479435016453 active site 479435016454 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 479435016455 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435016456 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435016457 DNA binding residues [nucleotide binding] 479435016458 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 479435016459 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 479435016460 ring oligomerisation interface [polypeptide binding]; other site 479435016461 ATP/Mg binding site [chemical binding]; other site 479435016462 stacking interactions; other site 479435016463 hinge regions; other site 479435016464 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 479435016465 oligomerisation interface [polypeptide binding]; other site 479435016466 mobile loop; other site 479435016467 roof hairpin; other site 479435016468 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479435016469 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435016470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435016471 S-adenosylmethionine binding site [chemical binding]; other site 479435016472 Phosphotransferase enzyme family; Region: APH; pfam01636 479435016473 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435016474 active site 479435016475 ATP binding site [chemical binding]; other site 479435016476 substrate binding site [chemical binding]; other site 479435016477 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435016478 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016479 Coenzyme A binding pocket [chemical binding]; other site 479435016480 UGMP family protein; Validated; Region: PRK09604 479435016481 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 479435016482 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 479435016483 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016484 Coenzyme A binding pocket [chemical binding]; other site 479435016485 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435016486 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 479435016487 Glycoprotease family; Region: Peptidase_M22; pfam00814 479435016488 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016489 Coenzyme A binding pocket [chemical binding]; other site 479435016490 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 479435016491 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 479435016492 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435016493 alanine racemase; Reviewed; Region: alr; PRK00053 479435016494 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 479435016495 active site 479435016496 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435016497 dimer interface [polypeptide binding]; other site 479435016498 substrate binding site [chemical binding]; other site 479435016499 catalytic residues [active] 479435016500 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 479435016501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435016502 motif II; other site 479435016503 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435016504 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435016505 putative dimerization interface [polypeptide binding]; other site 479435016506 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 479435016507 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435016508 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435016509 catalytic residue [active] 479435016510 META domain; Region: META; pfam03724 479435016511 META domain; Region: META; pfam03724 479435016512 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 479435016513 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_4; cd09619 479435016514 putative ligand binding site [chemical binding]; other site 479435016515 Uncharacterized conserved protein [Function unknown]; Region: COG0062 479435016516 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 479435016517 putative substrate binding site [chemical binding]; other site 479435016518 putative ATP binding site [chemical binding]; other site 479435016519 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 479435016520 pantothenate kinase; Provisional; Region: PRK05439 479435016521 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 479435016522 ATP-binding site [chemical binding]; other site 479435016523 CoA-binding site [chemical binding]; other site 479435016524 Mg2+-binding site [ion binding]; other site 479435016525 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435016526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435016527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016528 homodimer interface [polypeptide binding]; other site 479435016529 catalytic residue [active] 479435016530 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479435016531 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479435016532 active site 479435016533 substrate binding site [chemical binding]; other site 479435016534 FMN binding site [chemical binding]; other site 479435016535 putative catalytic residues [active] 479435016536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479435016537 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435016538 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 479435016539 active site 479435016540 catalytic triad [active] 479435016541 oxyanion hole [active] 479435016542 acyl-CoA synthetase; Validated; Region: PRK06188 479435016543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435016544 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435016545 acyl-activating enzyme (AAE) consensus motif; other site 479435016546 AMP binding site [chemical binding]; other site 479435016547 active site 479435016548 CoA binding site [chemical binding]; other site 479435016549 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435016550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016551 putative substrate translocation pore; other site 479435016552 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 479435016553 active site 479435016554 catalytic triad [active] 479435016555 oxyanion hole [active] 479435016556 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 479435016557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435016558 S-adenosylmethionine binding site [chemical binding]; other site 479435016559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435016560 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 479435016561 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 479435016562 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 479435016563 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479435016564 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479435016565 alpha subunit interface [polypeptide binding]; other site 479435016566 TPP binding site [chemical binding]; other site 479435016567 heterodimer interface [polypeptide binding]; other site 479435016568 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435016569 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479435016570 tetramer interface [polypeptide binding]; other site 479435016571 TPP-binding site [chemical binding]; other site 479435016572 heterodimer interface [polypeptide binding]; other site 479435016573 phosphorylation loop region [posttranslational modification] 479435016574 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 479435016575 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 479435016576 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 479435016577 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 479435016578 dimer interface [polypeptide binding]; other site 479435016579 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 479435016580 active site 479435016581 Fe binding site [ion binding]; other site 479435016582 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 479435016583 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 479435016584 dimer interface [polypeptide binding]; other site 479435016585 active site 479435016586 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479435016587 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435016588 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435016589 acyl-activating enzyme (AAE) consensus motif; other site 479435016590 acyl-activating enzyme (AAE) consensus motif; other site 479435016591 active site 479435016592 AMP binding site [chemical binding]; other site 479435016593 CoA binding site [chemical binding]; other site 479435016594 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479435016595 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 479435016596 active site 479435016597 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 479435016598 Phosphopantetheine attachment site; Region: PP-binding; cl09936 479435016599 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 479435016600 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 479435016601 AMP-binding enzyme; Region: AMP-binding; pfam00501 479435016602 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435016603 acyl-activating enzyme (AAE) consensus motif; other site 479435016604 AMP binding site [chemical binding]; other site 479435016605 active site 479435016606 CoA binding site [chemical binding]; other site 479435016607 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 479435016608 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 479435016609 putative active site [active] 479435016610 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 479435016611 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 479435016612 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 479435016613 putative active site [active] 479435016614 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435016615 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435016616 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435016617 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 479435016618 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435016619 putative catalytic site [active] 479435016620 putative metal binding site [ion binding]; other site 479435016621 putative phosphate binding site [ion binding]; other site 479435016622 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435016623 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479435016624 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435016625 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435016626 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479435016627 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435016628 Domain of unknown function (DUF4345); Region: DUF4345; pfam14248 479435016629 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435016630 putative catalytic site [active] 479435016631 putative metal binding site [ion binding]; other site 479435016632 putative phosphate binding site [ion binding]; other site 479435016633 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 479435016634 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 479435016635 active site 479435016636 substrate binding site [chemical binding]; other site 479435016637 metal binding site [ion binding]; metal-binding site 479435016638 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 479435016639 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 479435016640 23S rRNA interface [nucleotide binding]; other site 479435016641 L3 interface [polypeptide binding]; other site 479435016642 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 479435016643 Citrate synthase; Region: Citrate_synt; pfam00285 479435016644 oxalacetate binding site [chemical binding]; other site 479435016645 citrylCoA binding site [chemical binding]; other site 479435016646 coenzyme A binding site [chemical binding]; other site 479435016647 catalytic triad [active] 479435016648 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 479435016649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016651 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 479435016652 active site 479435016653 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 479435016654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435016655 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435016656 Walker A/P-loop; other site 479435016657 ATP binding site [chemical binding]; other site 479435016658 Q-loop/lid; other site 479435016659 ABC transporter signature motif; other site 479435016660 Walker B; other site 479435016661 D-loop; other site 479435016662 H-loop/switch region; other site 479435016663 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435016664 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435016665 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435016666 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435016667 DNA binding residues [nucleotide binding] 479435016668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435016669 S-adenosylmethionine binding site [chemical binding]; other site 479435016670 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 479435016671 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 479435016672 dimerization interface 3.5A [polypeptide binding]; other site 479435016673 active site 479435016674 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 479435016675 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 479435016676 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 479435016677 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 479435016678 alphaNTD homodimer interface [polypeptide binding]; other site 479435016679 alphaNTD - beta interaction site [polypeptide binding]; other site 479435016680 alphaNTD - beta' interaction site [polypeptide binding]; other site 479435016681 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 479435016682 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 479435016683 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 479435016684 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 479435016685 RNA binding surface [nucleotide binding]; other site 479435016686 30S ribosomal protein S11; Validated; Region: PRK05309 479435016687 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 479435016688 30S ribosomal protein S13; Region: bact_S13; TIGR03631 479435016689 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 479435016690 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 479435016691 rRNA binding site [nucleotide binding]; other site 479435016692 predicted 30S ribosome binding site; other site 479435016693 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435016694 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435016695 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 479435016696 active site 479435016697 adenylate kinase; Reviewed; Region: adk; PRK00279 479435016698 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 479435016699 AMP-binding site [chemical binding]; other site 479435016700 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 479435016701 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 479435016702 SecY translocase; Region: SecY; pfam00344 479435016703 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 479435016704 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 479435016705 23S rRNA binding site [nucleotide binding]; other site 479435016706 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 479435016707 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 479435016708 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 479435016709 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 479435016710 5S rRNA interface [nucleotide binding]; other site 479435016711 L27 interface [polypeptide binding]; other site 479435016712 23S rRNA interface [nucleotide binding]; other site 479435016713 L5 interface [polypeptide binding]; other site 479435016714 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 479435016715 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 479435016716 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 479435016717 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 479435016718 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 479435016719 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 479435016720 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 479435016721 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 479435016722 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 479435016723 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 479435016724 RNA binding site [nucleotide binding]; other site 479435016725 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 479435016726 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 479435016727 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 479435016728 23S rRNA interface [nucleotide binding]; other site 479435016729 putative translocon interaction site; other site 479435016730 signal recognition particle (SRP54) interaction site; other site 479435016731 L23 interface [polypeptide binding]; other site 479435016732 trigger factor interaction site; other site 479435016733 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 479435016734 23S rRNA interface [nucleotide binding]; other site 479435016735 5S rRNA interface [nucleotide binding]; other site 479435016736 putative antibiotic binding site [chemical binding]; other site 479435016737 L25 interface [polypeptide binding]; other site 479435016738 L27 interface [polypeptide binding]; other site 479435016739 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 479435016740 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 479435016741 G-X-X-G motif; other site 479435016742 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 479435016743 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 479435016744 putative translocon binding site; other site 479435016745 protein-rRNA interface [nucleotide binding]; other site 479435016746 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 479435016747 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 479435016748 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 479435016749 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 479435016750 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 479435016751 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 479435016752 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 479435016753 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 479435016754 elongation factor Tu; Reviewed; Region: PRK00049 479435016755 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 479435016756 G1 box; other site 479435016757 GEF interaction site [polypeptide binding]; other site 479435016758 GTP/Mg2+ binding site [chemical binding]; other site 479435016759 Switch I region; other site 479435016760 G2 box; other site 479435016761 G3 box; other site 479435016762 Switch II region; other site 479435016763 G4 box; other site 479435016764 G5 box; other site 479435016765 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 479435016766 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 479435016767 Antibiotic Binding Site [chemical binding]; other site 479435016768 elongation factor G; Reviewed; Region: PRK00007 479435016769 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 479435016770 G1 box; other site 479435016771 putative GEF interaction site [polypeptide binding]; other site 479435016772 GTP/Mg2+ binding site [chemical binding]; other site 479435016773 Switch I region; other site 479435016774 G2 box; other site 479435016775 G3 box; other site 479435016776 Switch II region; other site 479435016777 G4 box; other site 479435016778 G5 box; other site 479435016779 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 479435016780 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 479435016781 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 479435016782 30S ribosomal protein S7; Validated; Region: PRK05302 479435016783 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 479435016784 S17 interaction site [polypeptide binding]; other site 479435016785 S8 interaction site; other site 479435016786 16S rRNA interaction site [nucleotide binding]; other site 479435016787 streptomycin interaction site [chemical binding]; other site 479435016788 23S rRNA interaction site [nucleotide binding]; other site 479435016789 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 479435016790 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 479435016791 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 479435016792 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 479435016793 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 479435016794 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435016795 RibD C-terminal domain; Region: RibD_C; cl17279 479435016796 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 479435016797 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 479435016798 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 479435016799 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 479435016800 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 479435016801 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 479435016802 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 479435016803 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 479435016804 G-loop; other site 479435016805 DNA binding site [nucleotide binding] 479435016806 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 479435016807 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 479435016808 RPB12 interaction site [polypeptide binding]; other site 479435016809 RPB1 interaction site [polypeptide binding]; other site 479435016810 RPB10 interaction site [polypeptide binding]; other site 479435016811 RPB11 interaction site [polypeptide binding]; other site 479435016812 RPB3 interaction site [polypeptide binding]; other site 479435016813 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435016814 mce related protein; Region: MCE; pfam02470 479435016815 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435016816 mce related protein; Region: MCE; pfam02470 479435016817 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 479435016818 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435016819 mce related protein; Region: MCE; pfam02470 479435016820 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 479435016821 mce related protein; Region: MCE; pfam02470 479435016822 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 479435016823 mce related protein; Region: MCE; pfam02470 479435016824 mce related protein; Region: MCE; pfam02470 479435016825 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 479435016826 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 479435016827 Permease; Region: Permease; pfam02405 479435016828 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 479435016829 Permease; Region: Permease; pfam02405 479435016830 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 479435016831 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 479435016832 Walker A/P-loop; other site 479435016833 ATP binding site [chemical binding]; other site 479435016834 Q-loop/lid; other site 479435016835 ABC transporter signature motif; other site 479435016836 Walker B; other site 479435016837 D-loop; other site 479435016838 H-loop/switch region; other site 479435016839 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 479435016840 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 479435016841 core dimer interface [polypeptide binding]; other site 479435016842 peripheral dimer interface [polypeptide binding]; other site 479435016843 L10 interface [polypeptide binding]; other site 479435016844 L11 interface [polypeptide binding]; other site 479435016845 putative EF-Tu interaction site [polypeptide binding]; other site 479435016846 putative EF-G interaction site [polypeptide binding]; other site 479435016847 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 479435016848 23S rRNA interface [nucleotide binding]; other site 479435016849 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 479435016850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435016851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016852 putative substrate translocation pore; other site 479435016853 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435016854 homotrimer interaction site [polypeptide binding]; other site 479435016855 putative active site [active] 479435016856 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435016857 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435016858 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435016859 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435016860 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 479435016861 substrate binding site [chemical binding]; other site 479435016862 ATP binding site [chemical binding]; other site 479435016863 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 479435016864 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 479435016865 active site 479435016866 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435016867 dimer interface [polypeptide binding]; other site 479435016868 substrate binding site [chemical binding]; other site 479435016869 catalytic residue [active] 479435016870 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 479435016871 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 479435016872 active site 479435016873 putative substrate binding pocket [chemical binding]; other site 479435016874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435016875 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 479435016876 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 479435016877 active site 479435016878 intersubunit interface [polypeptide binding]; other site 479435016879 catalytic residue [active] 479435016880 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435016881 active site 479435016882 dimer interface [polypeptide binding]; other site 479435016883 motif 2; other site 479435016884 motif 3; other site 479435016885 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 479435016886 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 479435016887 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479435016888 active site 479435016889 substrate binding site [chemical binding]; other site 479435016890 FMN binding site [chemical binding]; other site 479435016891 putative catalytic residues [active] 479435016892 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 479435016893 mRNA/rRNA interface [nucleotide binding]; other site 479435016894 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 479435016895 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 479435016896 23S rRNA interface [nucleotide binding]; other site 479435016897 L7/L12 interface [polypeptide binding]; other site 479435016898 putative thiostrepton binding site; other site 479435016899 L25 interface [polypeptide binding]; other site 479435016900 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 479435016901 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 479435016902 putative homodimer interface [polypeptide binding]; other site 479435016903 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 479435016904 heterodimer interface [polypeptide binding]; other site 479435016905 homodimer interface [polypeptide binding]; other site 479435016906 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 479435016907 aspartate aminotransferase; Provisional; Region: PRK05764 479435016908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435016909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016910 homodimer interface [polypeptide binding]; other site 479435016911 catalytic residue [active] 479435016912 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 479435016913 active site 479435016914 catalytic triad [active] 479435016915 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 479435016916 adenosine deaminase; Provisional; Region: PRK09358 479435016917 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 479435016918 active site 479435016919 Hemerythrin-like domain; Region: Hr-like; cd12108 479435016920 Fe binding site [ion binding]; other site 479435016921 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 479435016922 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 479435016923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435016924 catalytic residue [active] 479435016925 PhoD-like phosphatase; Region: PhoD; pfam09423 479435016926 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435016927 putative active site [active] 479435016928 putative metal binding site [ion binding]; other site 479435016929 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 479435016930 FAD binding domain; Region: FAD_binding_4; pfam01565 479435016931 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 479435016932 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 479435016933 active site 479435016934 catalytic site [active] 479435016935 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 479435016936 active site 479435016937 catalytic site [active] 479435016938 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 479435016939 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 479435016940 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435016941 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435016942 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435016943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435016944 Coenzyme A binding pocket [chemical binding]; other site 479435016945 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 479435016946 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435016947 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435016948 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435016949 non-specific DNA binding site [nucleotide binding]; other site 479435016950 salt bridge; other site 479435016951 sequence-specific DNA binding site [nucleotide binding]; other site 479435016952 Cupin domain; Region: Cupin_2; pfam07883 479435016953 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 479435016954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 479435016955 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 479435016956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435016957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435016958 DNA binding site [nucleotide binding] 479435016959 domain linker motif; other site 479435016960 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435016961 dimerization interface [polypeptide binding]; other site 479435016962 ligand binding site [chemical binding]; other site 479435016963 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 479435016964 CGNR zinc finger; Region: zf-CGNR; pfam11706 479435016965 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435016966 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435016967 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435016968 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435016969 active site 479435016970 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 479435016971 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 479435016972 Methyltransferase domain; Region: Methyltransf_31; pfam13847 479435016973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435016974 S-adenosylmethionine binding site [chemical binding]; other site 479435016975 AAA domain; Region: AAA_33; pfam13671 479435016976 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479435016977 active site 479435016978 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 479435016979 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435016980 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435016981 active site 479435016982 catalytic tetrad [active] 479435016983 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435016984 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435016985 MarR family; Region: MarR_2; cl17246 479435016986 Transcriptional regulators [Transcription]; Region: MarR; COG1846 479435016987 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435016988 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435016989 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 479435016990 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016991 putative substrate translocation pore; other site 479435016992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435016993 AAA domain; Region: AAA_17; pfam13207 479435016994 AAA domain; Region: AAA_18; pfam13238 479435016995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 479435016996 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 479435016997 Phosphotransferase enzyme family; Region: APH; pfam01636 479435016998 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435016999 substrate binding site [chemical binding]; other site 479435017000 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435017001 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 479435017002 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 479435017003 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 479435017004 active site 479435017005 NTP binding site [chemical binding]; other site 479435017006 metal binding triad [ion binding]; metal-binding site 479435017007 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435017008 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435017009 putative DNA binding site [nucleotide binding]; other site 479435017010 dimerization interface [polypeptide binding]; other site 479435017011 putative Zn2+ binding site [ion binding]; other site 479435017012 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 479435017013 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 479435017014 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479435017015 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 479435017016 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479435017017 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479435017018 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 479435017019 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 479435017020 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 479435017021 4Fe-4S binding domain; Region: Fer4; pfam00037 479435017022 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 479435017023 FAD binding site [chemical binding]; other site 479435017024 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435017025 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 479435017026 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435017027 YCII-related domain; Region: YCII; cl00999 479435017028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435017029 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435017030 dimer interface [polypeptide binding]; other site 479435017031 phosphorylation site [posttranslational modification] 479435017032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435017033 ATP binding site [chemical binding]; other site 479435017034 Mg2+ binding site [ion binding]; other site 479435017035 G-X-G motif; other site 479435017036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435017037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435017038 active site 479435017039 phosphorylation site [posttranslational modification] 479435017040 intermolecular recognition site; other site 479435017041 dimerization interface [polypeptide binding]; other site 479435017042 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435017043 DNA binding site [nucleotide binding] 479435017044 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 479435017045 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435017046 HlyD family secretion protein; Region: HlyD_3; pfam13437 479435017047 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435017048 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435017049 Walker A/P-loop; other site 479435017050 ATP binding site [chemical binding]; other site 479435017051 Q-loop/lid; other site 479435017052 ABC transporter signature motif; other site 479435017053 Walker B; other site 479435017054 D-loop; other site 479435017055 H-loop/switch region; other site 479435017056 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435017057 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479435017058 FtsX-like permease family; Region: FtsX; pfam02687 479435017059 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 479435017060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435017061 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435017062 NAD(P) binding site [chemical binding]; other site 479435017063 active site 479435017064 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 479435017065 putative active site [active] 479435017066 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 479435017067 NADH dehydrogenase subunit B; Validated; Region: PRK06411 479435017068 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 479435017069 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 479435017070 Isochorismatase family; Region: Isochorismatase; pfam00857 479435017071 catalytic triad [active] 479435017072 conserved cis-peptide bond; other site 479435017073 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435017074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435017075 DNA-binding site [nucleotide binding]; DNA binding site 479435017076 UTRA domain; Region: UTRA; pfam07702 479435017077 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 479435017078 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 479435017079 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 479435017080 substrate binding site [chemical binding]; other site 479435017081 ATP binding site [chemical binding]; other site 479435017082 AAA ATPase domain; Region: AAA_16; pfam13191 479435017083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435017084 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435017085 dimerization interface [polypeptide binding]; other site 479435017086 DNA binding residues [nucleotide binding] 479435017087 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 479435017088 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 479435017089 active site 479435017090 dimer interface [polypeptide binding]; other site 479435017091 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 479435017092 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 479435017093 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 479435017094 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 479435017095 dimer interface [polypeptide binding]; other site 479435017096 PYR/PP interface [polypeptide binding]; other site 479435017097 TPP binding site [chemical binding]; other site 479435017098 substrate binding site [chemical binding]; other site 479435017099 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 479435017100 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 479435017101 TPP-binding site [chemical binding]; other site 479435017102 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435017103 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435017104 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435017105 hypothetical protein; Provisional; Region: PRK07758 479435017106 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 479435017107 oligomeric interface; other site 479435017108 putative active site [active] 479435017109 homodimer interface [polypeptide binding]; other site 479435017110 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 479435017111 Protein of unknown function (DUF445); Region: DUF445; pfam04286 479435017112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435017114 putative substrate translocation pore; other site 479435017115 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435017116 MarR family; Region: MarR_2; pfam12802 479435017117 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 479435017118 homotrimer interaction site [polypeptide binding]; other site 479435017119 putative active site [active] 479435017120 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 479435017121 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 479435017122 phosphate binding site [ion binding]; other site 479435017123 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479435017124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435017125 motif II; other site 479435017126 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435017127 Peptidase M15; Region: Peptidase_M15_3; cl01194 479435017128 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435017129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435017130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435017131 DNA binding residues [nucleotide binding] 479435017132 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435017133 Predicted permeases [General function prediction only]; Region: RarD; COG2962 479435017134 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 479435017135 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 479435017136 Predicted transcriptional regulator [Transcription]; Region: COG1959 479435017137 Transcriptional regulator; Region: Rrf2; pfam02082 479435017138 Cupin domain; Region: Cupin_2; pfam07883 479435017139 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 479435017140 hydrophobic ligand binding site; other site 479435017141 AAA domain; Region: AAA_33; pfam13671 479435017142 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479435017143 active site 479435017144 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 479435017145 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 479435017146 substrate binding pocket [chemical binding]; other site 479435017147 chain length determination region; other site 479435017148 substrate-Mg2+ binding site; other site 479435017149 catalytic residues [active] 479435017150 aspartate-rich region 1; other site 479435017151 active site lid residues [active] 479435017152 aspartate-rich region 2; other site 479435017153 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 479435017154 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479435017155 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 479435017156 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479435017157 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 479435017158 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 479435017159 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 479435017160 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 479435017161 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 479435017162 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 479435017163 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 479435017164 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 479435017165 4Fe-4S binding domain; Region: Fer4; pfam00037 479435017166 4Fe-4S binding domain; Region: Fer4; pfam00037 479435017167 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 479435017168 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 479435017169 NADH dehydrogenase subunit G; Validated; Region: PRK07860 479435017170 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 479435017171 catalytic loop [active] 479435017172 iron binding site [ion binding]; other site 479435017173 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 479435017174 MopB_NADH-Q-OR-NuoG2: The NuoG/Nad11/75-kDa subunit (second domain) of the NADH-quinone oxidoreductase (NADH-Q-OR)/respiratory complex I/NADH dehydrogenase-1 (NDH-1). The NADH-Q-OR is the first energy-transducting complex in the respiratory chains of...; Region: MopB_NADH-Q-OR-NuoG2; cd02768 479435017175 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 479435017176 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 479435017177 SLBB domain; Region: SLBB; pfam10531 479435017178 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 479435017179 NADH dehydrogenase subunit E; Validated; Region: PRK07539 479435017180 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 479435017181 putative dimer interface [polypeptide binding]; other site 479435017182 [2Fe-2S] cluster binding site [ion binding]; other site 479435017183 NADH dehydrogenase subunit D; Validated; Region: PRK06075 479435017184 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 479435017185 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 479435017186 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 479435017187 NADH dehydrogenase subunit B; Validated; Region: PRK06411 479435017188 NADH dehydrogenase subunit A; Validated; Region: PRK07928 479435017189 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 479435017190 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 479435017191 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435017192 S-adenosylmethionine binding site [chemical binding]; other site 479435017193 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 479435017194 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 479435017195 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 479435017196 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 479435017197 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 479435017198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435017199 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435017200 Transcriptional regulator PadR-like family; Region: PadR; cl17335 479435017201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435017202 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435017203 Walker A/P-loop; other site 479435017204 ATP binding site [chemical binding]; other site 479435017205 Q-loop/lid; other site 479435017206 ABC transporter signature motif; other site 479435017207 Walker B; other site 479435017208 D-loop; other site 479435017209 H-loop/switch region; other site 479435017210 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 479435017211 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 479435017212 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435017213 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 479435017214 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 479435017215 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 479435017216 dimer interface [polypeptide binding]; other site 479435017217 tetramer interface [polypeptide binding]; other site 479435017218 PYR/PP interface [polypeptide binding]; other site 479435017219 TPP binding site [chemical binding]; other site 479435017220 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 479435017221 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 479435017222 TPP-binding site; other site 479435017223 O-succinylbenzoate synthase; Provisional; Region: PRK02901 479435017224 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 479435017225 active site 479435017226 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435017227 acyl-activating enzyme (AAE) consensus motif; other site 479435017228 AMP binding site [chemical binding]; other site 479435017229 active site 479435017230 CoA binding site [chemical binding]; other site 479435017231 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 479435017232 UbiA prenyltransferase family; Region: UbiA; pfam01040 479435017233 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 479435017234 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 479435017235 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435017236 catalytic residue [active] 479435017237 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435017238 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435017239 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 479435017240 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 479435017241 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 479435017242 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435017243 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435017244 Coenzyme A binding pocket [chemical binding]; other site 479435017245 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 479435017246 active site 479435017247 catalytic triad [active] 479435017248 oxyanion hole [active] 479435017249 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 479435017250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017251 putative substrate translocation pore; other site 479435017252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017253 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435017254 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 479435017255 ResB-like family; Region: ResB; pfam05140 479435017256 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 479435017257 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 479435017258 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 479435017259 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 479435017260 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479435017261 catalytic residues [active] 479435017262 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435017263 catalytic core [active] 479435017264 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 479435017265 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 479435017266 inhibitor-cofactor binding pocket; inhibition site 479435017267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435017268 catalytic residue [active] 479435017269 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 479435017270 N-acetyl-D-glucosamine binding site [chemical binding]; other site 479435017271 catalytic residue [active] 479435017272 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 479435017273 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 479435017274 active site 479435017275 catalytic triad [active] 479435017276 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 479435017277 PA/protease or protease-like domain interface [polypeptide binding]; other site 479435017278 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435017279 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435017280 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435017281 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479435017282 acyl-activating enzyme (AAE) consensus motif; other site 479435017283 AMP binding site [chemical binding]; other site 479435017284 active site 479435017285 CoA binding site [chemical binding]; other site 479435017286 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 479435017287 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 479435017288 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 479435017289 active site 479435017290 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 479435017291 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 479435017292 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 479435017293 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 479435017294 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479435017295 Condensation domain; Region: Condensation; pfam00668 479435017296 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435017297 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435017298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 479435017299 acyl-activating enzyme (AAE) consensus motif; other site 479435017300 AMP binding site [chemical binding]; other site 479435017301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 479435017302 Condensation domain; Region: Condensation; pfam00668 479435017303 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 479435017304 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 479435017305 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435017306 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 479435017307 Calx-beta domain; Region: Calx-beta; cl02522 479435017308 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 479435017309 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 479435017310 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 479435017311 MMPL family; Region: MMPL; pfam03176 479435017312 MMPL family; Region: MMPL; pfam03176 479435017313 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435017314 conserved cys residue [active] 479435017315 Isochorismatase family; Region: Isochorismatase; pfam00857 479435017316 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 479435017317 catalytic triad [active] 479435017318 conserved cis-peptide bond; other site 479435017319 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 479435017320 active site 479435017321 catalytic residues [active] 479435017322 Putative amidotransferase; Region: DUF4066; pfam13278 479435017323 conserved cys residue [active] 479435017324 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 479435017325 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 479435017326 conserved cys residue [active] 479435017327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435017328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435017329 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435017330 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 479435017331 NADP binding site [chemical binding]; other site 479435017332 homodimer interface [polypeptide binding]; other site 479435017333 active site 479435017334 substrate binding site [chemical binding]; other site 479435017335 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435017336 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017337 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 479435017338 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 479435017339 DNA binding residues [nucleotide binding] 479435017340 putative dimer interface [polypeptide binding]; other site 479435017341 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435017342 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 479435017343 Cytochrome P450; Region: p450; cl12078 479435017344 Phosphotransferase enzyme family; Region: APH; pfam01636 479435017345 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 479435017346 active site 479435017347 ATP binding site [chemical binding]; other site 479435017348 Methane oxygenase PmoA; Region: PmoA; pfam14100 479435017349 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435017350 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435017351 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435017352 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435017353 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435017354 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435017355 dimer interface [polypeptide binding]; other site 479435017356 conserved gate region; other site 479435017357 putative PBP binding loops; other site 479435017358 ABC-ATPase subunit interface; other site 479435017359 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435017360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435017361 putative PBP binding loops; other site 479435017362 dimer interface [polypeptide binding]; other site 479435017363 ABC-ATPase subunit interface; other site 479435017364 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435017365 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435017366 DNA binding site [nucleotide binding] 479435017367 domain linker motif; other site 479435017368 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435017369 ligand binding site [chemical binding]; other site 479435017370 dimerization interface [polypeptide binding]; other site 479435017371 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 479435017372 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435017373 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435017374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435017375 dimer interface [polypeptide binding]; other site 479435017376 conserved gate region; other site 479435017377 putative PBP binding loops; other site 479435017378 ABC-ATPase subunit interface; other site 479435017379 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435017380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435017381 dimer interface [polypeptide binding]; other site 479435017382 conserved gate region; other site 479435017383 putative PBP binding loops; other site 479435017384 ABC-ATPase subunit interface; other site 479435017385 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 479435017386 anti sigma factor interaction site; other site 479435017387 regulatory phosphorylation site [posttranslational modification]; other site 479435017388 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 479435017389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 479435017390 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 479435017391 B12 binding domain; Region: B12-binding_2; pfam02607 479435017392 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 479435017393 B12 binding site [chemical binding]; other site 479435017394 RibD C-terminal domain; Region: RibD_C; cl17279 479435017395 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435017396 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 479435017397 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435017398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017399 putative substrate translocation pore; other site 479435017400 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 479435017401 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 479435017402 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 479435017403 dimer interface [polypeptide binding]; other site 479435017404 active site 479435017405 Schiff base residues; other site 479435017406 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 479435017407 active site 479435017408 SAM binding site [chemical binding]; other site 479435017409 homodimer interface [polypeptide binding]; other site 479435017410 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 479435017411 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 479435017412 active site 479435017413 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 479435017414 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 479435017415 domain interfaces; other site 479435017416 active site 479435017417 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 479435017418 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 479435017419 tRNA; other site 479435017420 putative tRNA binding site [nucleotide binding]; other site 479435017421 putative NADP binding site [chemical binding]; other site 479435017422 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 479435017423 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 479435017424 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 479435017425 CoA binding domain; Region: CoA_binding; pfam02629 479435017426 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 479435017427 catalytic residues [active] 479435017428 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 479435017429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435017430 acyl-activating enzyme (AAE) consensus motif; other site 479435017431 AMP binding site [chemical binding]; other site 479435017432 active site 479435017433 CoA binding site [chemical binding]; other site 479435017434 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435017435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435017436 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 479435017437 DNA binding residues [nucleotide binding] 479435017438 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 479435017439 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 479435017440 putative acyl-acceptor binding pocket; other site 479435017441 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435017442 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 479435017443 putative NAD(P) binding site [chemical binding]; other site 479435017444 active site 479435017445 putative substrate binding site [chemical binding]; other site 479435017446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435017447 S-adenosylmethionine binding site [chemical binding]; other site 479435017448 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435017449 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435017450 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 479435017451 DNA binding site [nucleotide binding] 479435017452 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435017453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435017454 DNA binding domain, excisionase family; Region: excise; TIGR01764 479435017455 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 479435017456 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 479435017457 active site 479435017458 Zn binding site [ion binding]; other site 479435017459 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 479435017460 active site 479435017461 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 479435017462 HIGH motif; other site 479435017463 dimer interface [polypeptide binding]; other site 479435017464 KMSKS motif; other site 479435017465 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 479435017466 putative catalytic site [active] 479435017467 putative metal binding site [ion binding]; other site 479435017468 putative phosphate binding site [ion binding]; other site 479435017469 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 479435017470 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 479435017471 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 479435017472 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 479435017473 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 479435017474 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 479435017475 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 479435017476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435017477 motif II; other site 479435017478 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 479435017479 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 479435017480 pyrroline-5-carboxylate reductase; Region: PLN02688 479435017481 Proline dehydrogenase; Region: Pro_dh; cl03282 479435017482 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435017483 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435017484 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 479435017485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 479435017486 Walker A/P-loop; other site 479435017487 ATP binding site [chemical binding]; other site 479435017488 Q-loop/lid; other site 479435017489 ABC transporter signature motif; other site 479435017490 Walker B; other site 479435017491 D-loop; other site 479435017492 H-loop/switch region; other site 479435017493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435017494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017495 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 479435017496 AP (apurinic/apyrimidinic) site pocket; other site 479435017497 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 479435017498 Metal-binding active site; metal-binding site 479435017499 exopolyphosphatase; Region: exo_poly_only; TIGR03706 479435017500 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 479435017501 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435017502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435017503 NAD(P) binding site [chemical binding]; other site 479435017504 active site 479435017505 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 479435017506 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 479435017507 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 479435017508 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 479435017509 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 479435017510 active site 479435017511 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435017512 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017513 putative substrate translocation pore; other site 479435017514 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435017515 Coenzyme A binding pocket [chemical binding]; other site 479435017516 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435017517 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435017518 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435017519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435017520 S-adenosylmethionine binding site [chemical binding]; other site 479435017521 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435017522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435017523 conserved gate region; other site 479435017524 putative PBP binding loops; other site 479435017525 ABC-ATPase subunit interface; other site 479435017526 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435017527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 479435017528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435017529 DNA repair protein RadA; Provisional; Region: PRK11823 479435017530 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 479435017531 Walker A motif/ATP binding site; other site 479435017532 ATP binding site [chemical binding]; other site 479435017533 Walker B motif; other site 479435017534 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 479435017535 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 479435017536 RibD C-terminal domain; Region: RibD_C; cl17279 479435017537 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 479435017538 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 479435017539 dimer interface [polypeptide binding]; other site 479435017540 active site 479435017541 CoA binding pocket [chemical binding]; other site 479435017542 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 479435017543 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 479435017544 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 479435017545 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 479435017546 endonuclease III; Region: ENDO3c; smart00478 479435017547 minor groove reading motif; other site 479435017548 helix-hairpin-helix signature motif; other site 479435017549 substrate binding pocket [chemical binding]; other site 479435017550 active site 479435017551 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 479435017552 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 479435017553 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 479435017554 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435017555 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435017556 DNA binding residues [nucleotide binding] 479435017557 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 479435017558 Clp amino terminal domain; Region: Clp_N; pfam02861 479435017559 Clp amino terminal domain; Region: Clp_N; pfam02861 479435017560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435017561 Walker A motif; other site 479435017562 ATP binding site [chemical binding]; other site 479435017563 Walker B motif; other site 479435017564 arginine finger; other site 479435017565 UvrB/uvrC motif; Region: UVR; pfam02151 479435017566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435017567 Walker A motif; other site 479435017568 ATP binding site [chemical binding]; other site 479435017569 Walker B motif; other site 479435017570 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 479435017571 Lsr2; Region: Lsr2; pfam11774 479435017572 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 479435017573 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 479435017574 dimer interface [polypeptide binding]; other site 479435017575 putative anticodon binding site; other site 479435017576 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435017577 motif 1; other site 479435017578 dimer interface [polypeptide binding]; other site 479435017579 active site 479435017580 motif 2; other site 479435017581 motif 3; other site 479435017582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017583 putative substrate translocation pore; other site 479435017584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435017585 dimerization interface [polypeptide binding]; other site 479435017586 putative DNA binding site [nucleotide binding]; other site 479435017587 putative Zn2+ binding site [ion binding]; other site 479435017588 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 479435017589 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 479435017590 pantothenate kinase; Reviewed; Region: PRK13318 479435017591 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 479435017592 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 479435017593 dimerization interface [polypeptide binding]; other site 479435017594 active site 479435017595 L-aspartate oxidase; Provisional; Region: PRK07804 479435017596 L-aspartate oxidase; Provisional; Region: PRK06175 479435017597 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 479435017598 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 479435017599 active site 479435017600 KMSKS motif; other site 479435017601 Rossmann-like domain; Region: Rossmann-like; pfam10727 479435017602 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 479435017603 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 479435017604 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 479435017605 Predicted membrane protein [Function unknown]; Region: COG3428 479435017606 Bacterial PH domain; Region: DUF304; pfam03703 479435017607 Bacterial PH domain; Region: DUF304; pfam03703 479435017608 Uncharacterized conserved protein [Function unknown]; Region: COG3402 479435017609 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 479435017610 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 479435017611 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435017612 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435017613 non-specific DNA binding site [nucleotide binding]; other site 479435017614 salt bridge; other site 479435017615 sequence-specific DNA binding site [nucleotide binding]; other site 479435017616 HipA N-terminal domain; Region: Couple_hipA; cl11853 479435017617 HipA-like N-terminal domain; Region: HipA_N; pfam07805 479435017618 HipA-like C-terminal domain; Region: HipA_C; pfam07804 479435017619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435017620 S-adenosylmethionine binding site [chemical binding]; other site 479435017621 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 479435017622 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 479435017623 active site 479435017624 dimerization interface [polypeptide binding]; other site 479435017625 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 479435017626 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 479435017627 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 479435017628 catalytic center binding site [active] 479435017629 ATP binding site [chemical binding]; other site 479435017630 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 479435017631 homooctamer interface [polypeptide binding]; other site 479435017632 active site 479435017633 SnoaL-like domain; Region: SnoaL_3; pfam13474 479435017634 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435017635 dihydropteroate synthase; Region: DHPS; TIGR01496 479435017636 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 479435017637 substrate binding pocket [chemical binding]; other site 479435017638 dimer interface [polypeptide binding]; other site 479435017639 inhibitor binding site; inhibition site 479435017640 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 479435017641 homodecamer interface [polypeptide binding]; other site 479435017642 GTP cyclohydrolase I; Provisional; Region: PLN03044 479435017643 active site 479435017644 putative catalytic site residues [active] 479435017645 zinc binding site [ion binding]; other site 479435017646 GTP-CH-I/GFRP interaction surface; other site 479435017647 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 479435017648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435017649 Walker A motif; other site 479435017650 ATP binding site [chemical binding]; other site 479435017651 Walker B motif; other site 479435017652 arginine finger; other site 479435017653 Peptidase family M41; Region: Peptidase_M41; pfam01434 479435017654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435017655 active site 479435017656 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 479435017657 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 479435017658 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 479435017659 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 479435017660 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 479435017661 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 479435017662 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 479435017663 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 479435017664 dimer interface [polypeptide binding]; other site 479435017665 substrate binding site [chemical binding]; other site 479435017666 metal binding sites [ion binding]; metal-binding site 479435017667 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 479435017668 NlpC/P60 family; Region: NLPC_P60; pfam00877 479435017669 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435017670 putative catalytic site [active] 479435017671 putative metal binding site [ion binding]; other site 479435017672 putative phosphate binding site [ion binding]; other site 479435017673 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 479435017674 bile acid transporter; Region: bass; TIGR00841 479435017675 Sodium Bile acid symporter family; Region: SBF; pfam01758 479435017676 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 479435017677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435017678 NAD(P) binding site [chemical binding]; other site 479435017679 active site 479435017680 Domain of unknown function DUF77; Region: DUF77; pfam01910 479435017681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017682 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435017683 putative substrate translocation pore; other site 479435017684 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017685 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 479435017686 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017687 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 479435017688 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 479435017689 RNA polymerase factor sigma-70; Validated; Region: PRK08241 479435017690 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435017691 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435017692 DNA binding residues [nucleotide binding] 479435017693 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435017694 RibD C-terminal domain; Region: RibD_C; cl17279 479435017695 FO synthase; Reviewed; Region: fbiC; PRK09234 479435017696 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435017697 FeS/SAM binding site; other site 479435017698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 479435017699 FeS/SAM binding site; other site 479435017700 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 479435017701 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435017702 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 479435017703 active site 479435017704 metal binding site [ion binding]; metal-binding site 479435017705 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 479435017706 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435017707 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435017708 active site 479435017709 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 479435017710 DNA binding residues [nucleotide binding] 479435017711 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 479435017712 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 479435017713 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435017714 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 479435017715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435017716 dimer interface [polypeptide binding]; other site 479435017717 conserved gate region; other site 479435017718 putative PBP binding loops; other site 479435017719 ABC-ATPase subunit interface; other site 479435017720 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 479435017721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435017722 Walker A/P-loop; other site 479435017723 ATP binding site [chemical binding]; other site 479435017724 Q-loop/lid; other site 479435017725 ABC transporter signature motif; other site 479435017726 Walker B; other site 479435017727 D-loop; other site 479435017728 H-loop/switch region; other site 479435017729 TOBE domain; Region: TOBE; pfam03459 479435017730 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 479435017731 heme binding pocket [chemical binding]; other site 479435017732 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435017733 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435017734 active site 479435017735 ATP binding site [chemical binding]; other site 479435017736 substrate binding site [chemical binding]; other site 479435017737 activation loop (A-loop); other site 479435017738 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 479435017739 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 479435017740 active site 479435017741 zinc binding site [ion binding]; other site 479435017742 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 479435017743 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 479435017744 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435017745 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 479435017746 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 479435017747 Walker A/P-loop; other site 479435017748 ATP binding site [chemical binding]; other site 479435017749 Q-loop/lid; other site 479435017750 ABC transporter signature motif; other site 479435017751 Walker B; other site 479435017752 D-loop; other site 479435017753 H-loop/switch region; other site 479435017754 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 479435017755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435017756 Walker A/P-loop; other site 479435017757 ATP binding site [chemical binding]; other site 479435017758 Q-loop/lid; other site 479435017759 ABC transporter signature motif; other site 479435017760 Walker B; other site 479435017761 D-loop; other site 479435017762 H-loop/switch region; other site 479435017763 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435017764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 479435017765 active site 479435017766 phosphorylation site [posttranslational modification] 479435017767 intermolecular recognition site; other site 479435017768 dimerization interface [polypeptide binding]; other site 479435017769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435017770 DNA binding residues [nucleotide binding] 479435017771 dimerization interface [polypeptide binding]; other site 479435017772 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 479435017773 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 479435017774 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 479435017775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435017776 2TM domain; Region: 2TM; pfam13239 479435017777 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 479435017778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017779 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 479435017780 AAA domain; Region: AAA_33; pfam13671 479435017781 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 479435017782 active site 479435017783 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 479435017784 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 479435017785 putative [Fe4-S4] binding site [ion binding]; other site 479435017786 putative molybdopterin cofactor binding site [chemical binding]; other site 479435017787 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 479435017788 molybdopterin cofactor binding site; other site 479435017789 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435017790 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435017791 DNA binding site [nucleotide binding] 479435017792 domain linker motif; other site 479435017793 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435017794 dimerization interface [polypeptide binding]; other site 479435017795 ligand binding site [chemical binding]; other site 479435017796 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 479435017797 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435017798 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435017799 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 479435017800 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 479435017801 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 479435017802 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 479435017803 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435017804 DNA binding residues [nucleotide binding] 479435017805 dimer interface [polypeptide binding]; other site 479435017806 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 479435017807 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 479435017808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017809 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 479435017810 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 479435017811 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435017812 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 479435017813 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 479435017814 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 479435017815 entry exclusion lipoprotein TrbK; Region: TrbK_RP4; TIGR04359 479435017816 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 479435017817 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435017818 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 479435017819 tetramerization interface [polypeptide binding]; other site 479435017820 NAD(P) binding site [chemical binding]; other site 479435017821 catalytic residues [active] 479435017822 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 479435017823 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 479435017824 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 479435017825 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 479435017826 active site 479435017827 zinc binding site [ion binding]; other site 479435017828 AAA ATPase domain; Region: AAA_16; pfam13191 479435017829 Predicted ATPase [General function prediction only]; Region: COG3899 479435017830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435017831 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435017832 DNA binding residues [nucleotide binding] 479435017833 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 479435017834 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 479435017835 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435017836 TspO/MBR family; Region: TspO_MBR; pfam03073 479435017837 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 479435017838 Uncharacterized protein family (UPF0220); Region: UPF0220; pfam05255 479435017839 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 479435017840 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 479435017841 dimer interface [polypeptide binding]; other site 479435017842 putative anticodon binding site; other site 479435017843 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 479435017844 motif 1; other site 479435017845 dimer interface [polypeptide binding]; other site 479435017846 active site 479435017847 motif 2; other site 479435017848 motif 3; other site 479435017849 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 479435017850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435017851 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435017852 salt bridge; other site 479435017853 non-specific DNA binding site [nucleotide binding]; other site 479435017854 sequence-specific DNA binding site [nucleotide binding]; other site 479435017855 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435017856 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 479435017857 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 479435017858 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 479435017859 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 479435017860 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435017861 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 479435017862 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435017863 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 479435017864 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 479435017865 proline aminopeptidase P II; Provisional; Region: PRK10879 479435017866 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 479435017867 active site 479435017868 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435017869 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435017870 DNA-binding site [nucleotide binding]; DNA binding site 479435017871 FCD domain; Region: FCD; pfam07729 479435017872 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 479435017873 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 479435017874 putative active site [active] 479435017875 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 479435017876 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 479435017877 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 479435017878 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 479435017879 Proline racemase; Region: Pro_racemase; pfam05544 479435017880 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 479435017881 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 479435017882 inhibitor site; inhibition site 479435017883 active site 479435017884 dimer interface [polypeptide binding]; other site 479435017885 catalytic residue [active] 479435017886 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 479435017887 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 479435017888 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 479435017889 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 479435017890 hydroxyglutarate oxidase; Provisional; Region: PRK11728 479435017891 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435017892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435017893 non-specific DNA binding site [nucleotide binding]; other site 479435017894 salt bridge; other site 479435017895 sequence-specific DNA binding site [nucleotide binding]; other site 479435017896 Cupin domain; Region: Cupin_2; pfam07883 479435017897 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 479435017898 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 479435017899 NAD(P) binding site [chemical binding]; other site 479435017900 active site 479435017901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435017902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435017903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 479435017904 dimerization interface [polypeptide binding]; other site 479435017905 MarR family; Region: MarR; pfam01047 479435017906 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 479435017907 cleavage site 479435017908 active site 479435017909 substrate binding sites [chemical binding]; other site 479435017910 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435017911 active site 479435017912 catalytic site [active] 479435017913 tetracycline repressor protein TetR; Provisional; Region: PRK13756 479435017914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017915 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435017916 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435017917 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 479435017918 E3 interaction surface; other site 479435017919 lipoyl attachment site [posttranslational modification]; other site 479435017920 e3 binding domain; Region: E3_binding; pfam02817 479435017921 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479435017922 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 479435017923 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 479435017924 alpha subunit interface [polypeptide binding]; other site 479435017925 TPP binding site [chemical binding]; other site 479435017926 heterodimer interface [polypeptide binding]; other site 479435017927 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 479435017928 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 479435017929 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479435017930 tetramer interface [polypeptide binding]; other site 479435017931 TPP-binding site [chemical binding]; other site 479435017932 heterodimer interface [polypeptide binding]; other site 479435017933 phosphorylation loop region [posttranslational modification] 479435017934 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479435017935 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 479435017936 AsnC family; Region: AsnC_trans_reg; pfam01037 479435017937 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 479435017938 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 479435017939 catalytic residue [active] 479435017940 putative FPP diphosphate binding site; other site 479435017941 putative FPP binding hydrophobic cleft; other site 479435017942 dimer interface [polypeptide binding]; other site 479435017943 putative IPP diphosphate binding site; other site 479435017944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435017945 Coenzyme A binding pocket [chemical binding]; other site 479435017946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 479435017947 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435017948 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 479435017949 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 479435017950 putative ligand binding site [chemical binding]; other site 479435017951 NAD binding site [chemical binding]; other site 479435017952 catalytic site [active] 479435017953 DinB family; Region: DinB; cl17821 479435017954 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435017955 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 479435017956 dimer interface [polypeptide binding]; other site 479435017957 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435017958 active site 479435017959 metal binding site [ion binding]; metal-binding site 479435017960 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 479435017961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 479435017962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435017963 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 479435017964 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 479435017965 putative metal binding site [ion binding]; other site 479435017966 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435017967 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017968 short chain dehydrogenase; Provisional; Region: PRK06500 479435017969 classical (c) SDRs; Region: SDR_c; cd05233 479435017970 NAD(P) binding site [chemical binding]; other site 479435017971 active site 479435017972 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435017973 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435017974 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435017975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435017976 putative substrate translocation pore; other site 479435017977 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435017978 S-adenosylmethionine binding site [chemical binding]; other site 479435017979 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 479435017980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435017981 DNA-binding site [nucleotide binding]; DNA binding site 479435017982 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435017983 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435017984 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435017985 Coenzyme A binding pocket [chemical binding]; other site 479435017986 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 479435017987 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435017988 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 479435017989 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 479435017990 Mg++ binding site [ion binding]; other site 479435017991 putative catalytic motif [active] 479435017992 putative substrate binding site [chemical binding]; other site 479435017993 Protein of unknown function (DUF3466); Region: DUF3466; pfam11949 479435017994 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435017995 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435017996 Amidohydrolase; Region: Amidohydro_4; pfam13147 479435017997 active site 479435017998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435017999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018000 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 479435018001 FtsX-like permease family; Region: FtsX; pfam02687 479435018002 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 479435018003 FtsX-like permease family; Region: FtsX; pfam02687 479435018004 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435018005 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435018006 Walker A/P-loop; other site 479435018007 ATP binding site [chemical binding]; other site 479435018008 Q-loop/lid; other site 479435018009 ABC transporter signature motif; other site 479435018010 Walker B; other site 479435018011 D-loop; other site 479435018012 H-loop/switch region; other site 479435018013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 479435018014 Histidine kinase; Region: HisKA_3; pfam07730 479435018015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435018016 ATP binding site [chemical binding]; other site 479435018017 Mg2+ binding site [ion binding]; other site 479435018018 G-X-G motif; other site 479435018019 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435018020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435018021 active site 479435018022 phosphorylation site [posttranslational modification] 479435018023 intermolecular recognition site; other site 479435018024 dimerization interface [polypeptide binding]; other site 479435018025 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435018026 DNA binding residues [nucleotide binding] 479435018027 dimerization interface [polypeptide binding]; other site 479435018028 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435018029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435018030 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435018031 DNA binding residues [nucleotide binding] 479435018032 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 479435018033 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 479435018034 putative sugar binding sites [chemical binding]; other site 479435018035 Q-X-W motif; other site 479435018036 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 479435018037 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435018038 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435018039 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479435018040 catalytic site [active] 479435018041 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435018042 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435018043 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435018044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435018045 NAD(P) binding site [chemical binding]; other site 479435018046 active site 479435018047 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479435018048 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 479435018049 active site 479435018050 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 479435018051 hypothetical protein; Reviewed; Region: PRK09588 479435018052 putative hydrolase; Provisional; Region: PRK11460 479435018053 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 479435018054 FAD binding domain; Region: FAD_binding_4; pfam01565 479435018055 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 479435018056 dihydroxy-acid dehydratase; Validated; Region: PRK06131 479435018057 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 479435018058 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 479435018059 dimer interface [polypeptide binding]; other site 479435018060 NADP binding site [chemical binding]; other site 479435018061 catalytic residues [active] 479435018062 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479435018063 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 479435018064 galactarate dehydratase; Region: galactar-dH20; TIGR03248 479435018065 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 479435018066 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 479435018067 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435018068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018069 DNA-binding site [nucleotide binding]; DNA binding site 479435018070 FCD domain; Region: FCD; pfam07729 479435018071 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 479435018072 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 479435018073 putative substrate translocation pore; other site 479435018074 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 479435018075 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 479435018076 FMN binding site [chemical binding]; other site 479435018077 active site 479435018078 substrate binding site [chemical binding]; other site 479435018079 catalytic residue [active] 479435018080 AAA ATPase domain; Region: AAA_16; pfam13191 479435018081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435018082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435018083 DNA binding residues [nucleotide binding] 479435018084 dimerization interface [polypeptide binding]; other site 479435018085 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 479435018086 Peptidase family M48; Region: Peptidase_M48; cl12018 479435018087 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 479435018088 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 479435018089 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 479435018090 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 479435018091 active site 479435018092 catalytic site [active] 479435018093 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_10; cd12171 479435018094 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 479435018095 putative ligand binding site [chemical binding]; other site 479435018096 putative NAD binding site [chemical binding]; other site 479435018097 catalytic site [active] 479435018098 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 479435018099 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 479435018100 putative N- and C-terminal domain interface [polypeptide binding]; other site 479435018101 putative active site [active] 479435018102 MgATP binding site [chemical binding]; other site 479435018103 putative xylulose binding site [chemical binding]; other site 479435018104 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 479435018105 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 479435018106 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 479435018107 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435018108 catalytic core [active] 479435018109 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 479435018110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 479435018111 nucleotide binding site [chemical binding]; other site 479435018112 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 479435018113 active site 479435018114 nucleophile elbow; other site 479435018115 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 479435018116 active site 479435018117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435018118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018119 dimer interface [polypeptide binding]; other site 479435018120 conserved gate region; other site 479435018121 putative PBP binding loops; other site 479435018122 ABC-ATPase subunit interface; other site 479435018123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018124 dimer interface [polypeptide binding]; other site 479435018125 conserved gate region; other site 479435018126 putative PBP binding loops; other site 479435018127 ABC-ATPase subunit interface; other site 479435018128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435018129 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 479435018130 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 479435018131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435018132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435018133 active site 479435018134 ATP binding site [chemical binding]; other site 479435018135 substrate binding site [chemical binding]; other site 479435018136 activation loop (A-loop); other site 479435018137 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 479435018138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435018139 DNA binding residues [nucleotide binding] 479435018140 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 479435018141 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 479435018142 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 479435018143 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 479435018144 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 479435018145 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 479435018146 dimerization domain swap beta strand [polypeptide binding]; other site 479435018147 regulatory protein interface [polypeptide binding]; other site 479435018148 active site 479435018149 regulatory phosphorylation site [posttranslational modification]; other site 479435018150 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 479435018151 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 479435018152 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 479435018153 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 479435018154 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435018155 Coenzyme A binding pocket [chemical binding]; other site 479435018156 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435018157 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435018158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435018159 DNA binding residues [nucleotide binding] 479435018160 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 479435018161 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 479435018162 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 479435018163 dimerization interface [polypeptide binding]; other site 479435018164 ATP binding site [chemical binding]; other site 479435018165 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 479435018166 dimerization interface [polypeptide binding]; other site 479435018167 ATP binding site [chemical binding]; other site 479435018168 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 479435018169 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 479435018170 conserved cys residue [active] 479435018171 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 479435018172 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435018173 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435018174 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435018175 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435018176 Walker A/P-loop; other site 479435018177 ATP binding site [chemical binding]; other site 479435018178 Q-loop/lid; other site 479435018179 ABC transporter signature motif; other site 479435018180 Walker B; other site 479435018181 D-loop; other site 479435018182 H-loop/switch region; other site 479435018183 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 479435018184 OsmC-like protein; Region: OsmC; pfam02566 479435018185 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 479435018186 ATP binding site [chemical binding]; other site 479435018187 active site 479435018188 substrate binding site [chemical binding]; other site 479435018189 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 479435018190 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 479435018191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 479435018192 Cupin; Region: Cupin_6; pfam12852 479435018193 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435018194 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 479435018195 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 479435018196 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 479435018197 adenylosuccinate lyase; Region: purB; TIGR00928 479435018198 tetramer interface [polypeptide binding]; other site 479435018199 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 479435018200 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 479435018201 PhoD-like phosphatase; Region: PhoD; pfam09423 479435018202 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435018203 putative active site [active] 479435018204 putative metal binding site [ion binding]; other site 479435018205 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435018206 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 479435018207 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 479435018208 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 479435018209 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 479435018210 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435018211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018212 putative PBP binding loops; other site 479435018213 ABC-ATPase subunit interface; other site 479435018214 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435018215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018216 dimer interface [polypeptide binding]; other site 479435018217 conserved gate region; other site 479435018218 putative PBP binding loops; other site 479435018219 ABC-ATPase subunit interface; other site 479435018220 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 479435018221 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435018222 Helix-hairpin-helix motif; Region: HHH; pfam00633 479435018223 DEAD-like helicases superfamily; Region: DEXDc; smart00487 479435018224 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 479435018225 ATP binding site [chemical binding]; other site 479435018226 putative Mg++ binding site [ion binding]; other site 479435018227 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 479435018228 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435018229 nucleotide binding region [chemical binding]; other site 479435018230 ATP-binding site [chemical binding]; other site 479435018231 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435018232 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 479435018233 catalytic site [active] 479435018234 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 479435018235 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 479435018236 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 479435018237 Walker A/P-loop; other site 479435018238 ATP binding site [chemical binding]; other site 479435018239 Q-loop/lid; other site 479435018240 ABC transporter signature motif; other site 479435018241 Walker B; other site 479435018242 D-loop; other site 479435018243 H-loop/switch region; other site 479435018244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435018245 ABC-ATPase subunit interface; other site 479435018246 dimer interface [polypeptide binding]; other site 479435018247 putative PBP binding regions; other site 479435018248 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 479435018249 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 479435018250 ABC-ATPase subunit interface; other site 479435018251 dimer interface [polypeptide binding]; other site 479435018252 putative PBP binding regions; other site 479435018253 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 479435018254 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 479435018255 FAD binding pocket [chemical binding]; other site 479435018256 FAD binding motif [chemical binding]; other site 479435018257 phosphate binding motif [ion binding]; other site 479435018258 NAD binding pocket [chemical binding]; other site 479435018259 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435018260 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 479435018262 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 479435018263 conserved cys residue [active] 479435018264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 479435018265 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435018266 active site 479435018267 ATP binding site [chemical binding]; other site 479435018268 substrate binding site [chemical binding]; other site 479435018269 activation loop (A-loop); other site 479435018270 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 479435018271 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 479435018272 GDP-binding site [chemical binding]; other site 479435018273 ACT binding site; other site 479435018274 IMP binding site; other site 479435018275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 479435018276 putative dimer interface [polypeptide binding]; other site 479435018277 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435018278 Helix-turn-helix domain; Region: HTH_18; pfam12833 479435018279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435018280 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 479435018281 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 479435018282 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 479435018283 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 479435018284 active site 479435018285 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479435018286 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 479435018287 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 479435018288 active site 479435018289 intersubunit interface [polypeptide binding]; other site 479435018290 zinc binding site [ion binding]; other site 479435018291 Na+ binding site [ion binding]; other site 479435018292 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018293 DNA-binding site [nucleotide binding]; DNA binding site 479435018294 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 479435018295 UTRA domain; Region: UTRA; pfam07702 479435018296 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 479435018297 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 479435018298 dimer interface [polypeptide binding]; other site 479435018299 active site 479435018300 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 479435018301 dimer interface [polypeptide binding]; other site 479435018302 active site 479435018303 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 479435018304 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 479435018305 active site 479435018306 catalytic site [active] 479435018307 Cupin domain; Region: Cupin_2; cl17218 479435018308 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 479435018309 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 479435018310 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 479435018311 DNA binding site [nucleotide binding] 479435018312 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 479435018313 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435018314 AAA ATPase domain; Region: AAA_16; pfam13191 479435018315 NB-ARC domain; Region: NB-ARC; pfam00931 479435018316 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435018317 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435018318 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435018319 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 479435018320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 479435018321 active site 479435018322 Cytotoxic; Region: Cytotoxic; pfam09000 479435018323 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 479435018324 active site 479435018325 catalytic site [active] 479435018326 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 479435018327 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435018328 NAD(P) binding site [chemical binding]; other site 479435018329 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 479435018330 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 479435018331 substrate-cofactor binding pocket; other site 479435018332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435018333 catalytic residue [active] 479435018334 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 479435018335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 479435018336 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 479435018337 active site 479435018338 catalytic tetrad [active] 479435018339 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 479435018340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435018341 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 479435018342 dimerization interface [polypeptide binding]; other site 479435018343 substrate binding pocket [chemical binding]; other site 479435018344 Transcriptional regulator [Transcription]; Region: LysR; COG0583 479435018345 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435018346 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 479435018347 putative dimerization interface [polypeptide binding]; other site 479435018348 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 479435018349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435018350 non-specific DNA binding site [nucleotide binding]; other site 479435018351 salt bridge; other site 479435018352 sequence-specific DNA binding site [nucleotide binding]; other site 479435018353 AAA ATPase domain; Region: AAA_16; pfam13191 479435018354 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 479435018355 binding surface 479435018356 TPR motif; other site 479435018357 Tetratricopeptide repeat; Region: TPR_12; pfam13424 479435018358 Predicted transcriptional regulators [Transcription]; Region: COG1733 479435018359 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 479435018360 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 479435018361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435018362 NAD(P) binding site [chemical binding]; other site 479435018363 active site 479435018364 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 479435018365 putative catalytic site [active] 479435018366 putative metal binding site [ion binding]; other site 479435018367 putative phosphate binding site [ion binding]; other site 479435018368 short chain dehydrogenase; Provisional; Region: PRK08267 479435018369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435018370 NAD(P) binding site [chemical binding]; other site 479435018371 active site 479435018372 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 479435018373 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 479435018374 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435018375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018376 dimer interface [polypeptide binding]; other site 479435018377 conserved gate region; other site 479435018378 putative PBP binding loops; other site 479435018379 ABC-ATPase subunit interface; other site 479435018380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018381 dimer interface [polypeptide binding]; other site 479435018382 conserved gate region; other site 479435018383 putative PBP binding loops; other site 479435018384 ABC-ATPase subunit interface; other site 479435018385 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435018386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435018387 Transcriptional regulators [Transcription]; Region: FadR; COG2186 479435018388 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018389 DNA-binding site [nucleotide binding]; DNA binding site 479435018390 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 479435018391 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 479435018392 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 479435018393 putative metal binding site [ion binding]; other site 479435018394 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 479435018395 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435018396 homotrimer interaction site [polypeptide binding]; other site 479435018397 putative active site [active] 479435018398 aminotransferase; Validated; Region: PRK07777 479435018399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435018400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435018401 homodimer interface [polypeptide binding]; other site 479435018402 catalytic residue [active] 479435018403 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 479435018404 Clp amino terminal domain; Region: Clp_N; pfam02861 479435018405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435018406 Walker A motif; other site 479435018407 ATP binding site [chemical binding]; other site 479435018408 Walker B motif; other site 479435018409 arginine finger; other site 479435018410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435018411 Walker A motif; other site 479435018412 ATP binding site [chemical binding]; other site 479435018413 Walker B motif; other site 479435018414 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 479435018415 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 479435018416 active site 479435018417 catalytic residues [active] 479435018418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 479435018419 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 479435018420 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 479435018421 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435018422 DNA binding residues [nucleotide binding] 479435018423 putative dimer interface [polypeptide binding]; other site 479435018424 chaperone protein DnaJ; Provisional; Region: PRK14295 479435018425 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 479435018426 HSP70 interaction site [polypeptide binding]; other site 479435018427 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 479435018428 Zn binding sites [ion binding]; other site 479435018429 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 479435018430 dimer interface [polypeptide binding]; other site 479435018431 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 479435018432 dimer interface [polypeptide binding]; other site 479435018433 GrpE; Region: GrpE; pfam01025 479435018434 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 479435018435 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 479435018436 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 479435018437 nucleotide binding site [chemical binding]; other site 479435018438 NEF interaction site [polypeptide binding]; other site 479435018439 SBD interface [polypeptide binding]; other site 479435018440 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435018441 Coenzyme A binding pocket [chemical binding]; other site 479435018442 BNR repeat-like domain; Region: BNR_2; pfam13088 479435018443 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 479435018444 Asp-box motif; other site 479435018445 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 479435018446 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 479435018447 putative active site [active] 479435018448 imidazolonepropionase; Provisional; Region: PRK14085 479435018449 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 479435018450 active site 479435018451 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 479435018452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435018453 active site 479435018454 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 479435018455 allantoate amidohydrolase; Reviewed; Region: PRK09290 479435018456 active site 479435018457 metal binding site [ion binding]; metal-binding site 479435018458 dimer interface [polypeptide binding]; other site 479435018459 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 479435018460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018461 ABC-ATPase subunit interface; other site 479435018462 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018463 dimer interface [polypeptide binding]; other site 479435018464 conserved gate region; other site 479435018465 ABC-ATPase subunit interface; other site 479435018466 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 479435018467 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 479435018468 Walker A/P-loop; other site 479435018469 ATP binding site [chemical binding]; other site 479435018470 Q-loop/lid; other site 479435018471 ABC transporter signature motif; other site 479435018472 Walker B; other site 479435018473 D-loop; other site 479435018474 H-loop/switch region; other site 479435018475 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 479435018476 urocanate hydratase; Provisional; Region: PRK05414 479435018477 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479435018478 active sites [active] 479435018479 tetramer interface [polypeptide binding]; other site 479435018480 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435018481 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 479435018482 Coenzyme A binding pocket [chemical binding]; other site 479435018483 Predicted acetyltransferase [General function prediction only]; Region: COG2388 479435018484 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 479435018485 Transcriptional regulator [Transcription]; Region: IclR; COG1414 479435018486 Bacterial transcriptional regulator; Region: IclR; pfam01614 479435018487 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 479435018488 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 479435018489 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 479435018490 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 479435018491 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 479435018492 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 479435018493 active sites [active] 479435018494 tetramer interface [polypeptide binding]; other site 479435018495 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 479435018496 active site 479435018497 catalytic triad [active] 479435018498 oxyanion hole [active] 479435018499 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 479435018500 active site 479435018501 catalytic triad [active] 479435018502 oxyanion hole [active] 479435018503 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 479435018504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435018505 active site 479435018506 phosphorylation site [posttranslational modification] 479435018507 intermolecular recognition site; other site 479435018508 dimerization interface [polypeptide binding]; other site 479435018509 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435018510 DNA binding site [nucleotide binding] 479435018511 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 479435018512 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 479435018513 Ligand Binding Site [chemical binding]; other site 479435018514 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435018515 dimer interface [polypeptide binding]; other site 479435018516 phosphorylation site [posttranslational modification] 479435018517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435018518 ATP binding site [chemical binding]; other site 479435018519 Mg2+ binding site [ion binding]; other site 479435018520 G-X-G motif; other site 479435018521 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 479435018522 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 479435018523 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 479435018524 Soluble P-type ATPase [General function prediction only]; Region: COG4087 479435018525 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 479435018526 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435018527 homotrimer interaction site [polypeptide binding]; other site 479435018528 putative active site [active] 479435018529 Bifunctional DNA primase/polymerase, N-terminal; Region: Prim-Pol; smart00943 479435018530 Methyltransferase domain; Region: Methyltransf_11; pfam08241 479435018531 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 479435018532 Phosphotransferase enzyme family; Region: APH; pfam01636 479435018533 putative active site [active] 479435018534 putative substrate binding site [chemical binding]; other site 479435018535 ATP binding site [chemical binding]; other site 479435018536 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 479435018537 metal ion-dependent adhesion site (MIDAS); other site 479435018538 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 479435018539 active site 479435018540 Catalytic domain of Protein Kinases; Region: PKc; cd00180 479435018541 active site 479435018542 ATP binding site [chemical binding]; other site 479435018543 substrate binding site [chemical binding]; other site 479435018544 activation loop (A-loop); other site 479435018545 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 479435018546 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435018547 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435018548 DNA binding site [nucleotide binding] 479435018549 domain linker motif; other site 479435018550 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 479435018551 dimerization interface [polypeptide binding]; other site 479435018552 ligand binding site [chemical binding]; other site 479435018553 GAF domain; Region: GAF; pfam01590 479435018554 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 479435018555 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 479435018556 NAD(P) binding site [chemical binding]; other site 479435018557 catalytic residues [active] 479435018558 Protein of unknown function (DUF779); Region: DUF779; pfam05610 479435018559 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 479435018560 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 479435018561 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 479435018562 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 479435018563 Zn binding site [ion binding]; other site 479435018564 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 479435018565 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435018566 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435018567 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018568 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 479435018569 4Fe-4S binding domain; Region: Fer4; cl02805 479435018570 4Fe-4S binding domain; Region: Fer4; pfam00037 479435018571 Cysteine-rich domain; Region: CCG; pfam02754 479435018572 Cysteine-rich domain; Region: CCG; pfam02754 479435018573 PhoD-like phosphatase; Region: PhoD; pfam09423 479435018574 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 479435018575 putative active site [active] 479435018576 putative metal binding site [ion binding]; other site 479435018577 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 479435018578 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435018579 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 479435018580 classical (c) SDRs; Region: SDR_c; cd05233 479435018581 NAD(P) binding site [chemical binding]; other site 479435018582 active site 479435018583 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 479435018584 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435018585 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435018586 PQQ-like domain; Region: PQQ_2; pfam13360 479435018587 PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075 479435018588 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 479435018589 trimer interface [polypeptide binding]; other site 479435018590 active site 479435018591 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 479435018592 MarR family; Region: MarR_2; pfam12802 479435018593 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 479435018594 substrate binding site [chemical binding]; other site 479435018595 catalytic residues [active] 479435018596 G5 domain; Region: G5; pfam07501 479435018597 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435018598 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 479435018599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435018600 Coenzyme A binding pocket [chemical binding]; other site 479435018601 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435018602 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435018603 DNA binding residues [nucleotide binding] 479435018604 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 479435018605 beta-clamp/clamp loader binding surface; other site 479435018606 beta-clamp/translesion DNA polymerase binding surface; other site 479435018607 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 479435018608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435018609 metabolite-proton symporter; Region: 2A0106; TIGR00883 479435018610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435018611 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 479435018612 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 479435018613 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 479435018614 FAD binding site [chemical binding]; other site 479435018615 substrate binding site [chemical binding]; other site 479435018616 catalytic residues [active] 479435018617 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 479435018618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 479435018619 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 479435018620 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435018621 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435018622 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 479435018623 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 479435018624 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 479435018625 NHL repeat; Region: NHL; pfam01436 479435018626 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 479435018627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018628 dimer interface [polypeptide binding]; other site 479435018629 conserved gate region; other site 479435018630 putative PBP binding loops; other site 479435018631 ABC-ATPase subunit interface; other site 479435018632 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 479435018633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 479435018634 ABC-ATPase subunit interface; other site 479435018635 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 479435018636 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 479435018637 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 479435018638 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 479435018639 catalytic Zn binding site [ion binding]; other site 479435018640 NAD(P) binding site [chemical binding]; other site 479435018641 structural Zn binding site [ion binding]; other site 479435018642 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 479435018643 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435018644 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435018645 phenylacetic acid degradation protein paaN; Region: PaaN_2; TIGR02288 479435018646 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 479435018647 NAD(P) binding site [chemical binding]; other site 479435018648 catalytic residues [active] 479435018649 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 479435018650 CoenzymeA binding site [chemical binding]; other site 479435018651 subunit interaction site [polypeptide binding]; other site 479435018652 PHB binding site; other site 479435018653 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 479435018654 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 479435018655 dimer interface [polypeptide binding]; other site 479435018656 active site 479435018657 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 479435018658 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 479435018659 acyl-activating enzyme (AAE) consensus motif; other site 479435018660 AMP binding site [chemical binding]; other site 479435018661 active site 479435018662 CoA binding site [chemical binding]; other site 479435018663 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435018664 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018665 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435018666 Protein of unknown function (DUF433); Region: DUF433; pfam04255 479435018667 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435018668 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435018669 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 479435018670 AAA ATPase domain; Region: AAA_16; pfam13191 479435018671 Predicted ATPase [General function prediction only]; Region: COG3903 479435018672 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435018673 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018674 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435018675 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435018676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435018677 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435018678 Walker A/P-loop; other site 479435018679 ATP binding site [chemical binding]; other site 479435018680 Q-loop/lid; other site 479435018681 ABC transporter signature motif; other site 479435018682 Walker B; other site 479435018683 D-loop; other site 479435018684 H-loop/switch region; other site 479435018685 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435018686 putative substrate translocation pore; other site 479435018687 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435018688 Transcriptional regulators [Transcription]; Region: GntR; COG1802 479435018689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018690 DNA-binding site [nucleotide binding]; DNA binding site 479435018691 FCD domain; Region: FCD; pfam07729 479435018692 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 479435018693 catalytic triad [active] 479435018694 putative active site [active] 479435018695 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 479435018696 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 479435018697 E3 interaction surface; other site 479435018698 lipoyl attachment site [posttranslational modification]; other site 479435018699 e3 binding domain; Region: E3_binding; pfam02817 479435018700 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 479435018701 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 479435018702 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 479435018703 TPP-binding site [chemical binding]; other site 479435018704 heterodimer interface [polypeptide binding]; other site 479435018705 tetramer interface [polypeptide binding]; other site 479435018706 phosphorylation loop region [posttranslational modification] 479435018707 Phytase; Region: Phytase; cl17685 479435018708 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 479435018709 EamA-like transporter family; Region: EamA; pfam00892 479435018710 short chain dehydrogenase; Provisional; Region: PRK07023 479435018711 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435018712 NAD(P) binding site [chemical binding]; other site 479435018713 active site 479435018714 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 479435018715 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435018716 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435018717 homodimer interface [polypeptide binding]; other site 479435018718 catalytic residue [active] 479435018719 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 479435018720 Amidinotransferase; Region: Amidinotransf; pfam02274 479435018721 PEGA domain; Region: PEGA; pfam08308 479435018722 Peptidase family M23; Region: Peptidase_M23; pfam01551 479435018723 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 479435018724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018725 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 479435018726 DNA-binding site [nucleotide binding]; DNA binding site 479435018727 FCD domain; Region: FCD; pfam07729 479435018728 Membrane protein of unknown function; Region: DUF360; pfam04020 479435018729 Low molecular weight phosphatase family; Region: LMWPc; cd00115 479435018730 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 479435018731 active site 479435018732 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 479435018733 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 479435018734 active site 479435018735 ADP/pyrophosphate binding site [chemical binding]; other site 479435018736 dimerization interface [polypeptide binding]; other site 479435018737 allosteric effector site; other site 479435018738 fructose-1,6-bisphosphate binding site; other site 479435018739 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 479435018740 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479435018741 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435018742 putative DNA binding site [nucleotide binding]; other site 479435018743 putative Zn2+ binding site [ion binding]; other site 479435018744 AsnC family; Region: AsnC_trans_reg; pfam01037 479435018745 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435018746 EamA-like transporter family; Region: EamA; pfam00892 479435018747 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 479435018748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435018749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435018750 active site 479435018751 phosphorylation site [posttranslational modification] 479435018752 intermolecular recognition site; other site 479435018753 dimerization interface [polypeptide binding]; other site 479435018754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435018755 DNA binding site [nucleotide binding] 479435018756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435018757 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435018758 dimerization interface [polypeptide binding]; other site 479435018759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435018760 dimer interface [polypeptide binding]; other site 479435018761 phosphorylation site [posttranslational modification] 479435018762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435018763 ATP binding site [chemical binding]; other site 479435018764 Mg2+ binding site [ion binding]; other site 479435018765 G-X-G motif; other site 479435018766 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 479435018767 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 479435018768 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 479435018769 protein binding site [polypeptide binding]; other site 479435018770 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435018771 DinB superfamily; Region: DinB_2; pfam12867 479435018772 Pirin-related protein [General function prediction only]; Region: COG1741 479435018773 Pirin; Region: Pirin; pfam02678 479435018774 Domain of unknown function (DUF718); Region: DUF718; pfam05336 479435018775 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435018776 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435018777 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435018778 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 479435018779 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 479435018780 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 479435018781 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 479435018782 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 479435018783 Walker A motif; other site 479435018784 ATP binding site [chemical binding]; other site 479435018785 Walker B motif; other site 479435018786 arginine finger; other site 479435018787 SnoaL-like domain; Region: SnoaL_2; pfam12680 479435018788 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 479435018789 Transcription factor WhiB; Region: Whib; pfam02467 479435018790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 479435018791 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 479435018792 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435018793 Coenzyme A binding pocket [chemical binding]; other site 479435018794 DNA polymerase IV; Validated; Region: PRK03352 479435018795 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 479435018796 active site 479435018797 DNA binding site [nucleotide binding] 479435018798 Amidohydrolase; Region: Amidohydro_2; pfam04909 479435018799 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 479435018800 active site 479435018801 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 479435018802 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 479435018803 ligand binding site [chemical binding]; other site 479435018804 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 479435018805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018806 DNA-binding site [nucleotide binding]; DNA binding site 479435018807 FCD domain; Region: FCD; pfam07729 479435018808 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 479435018809 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 479435018810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435018811 active site 479435018812 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 479435018813 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 479435018814 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 479435018815 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435018816 putative substrate translocation pore; other site 479435018817 helicase 45; Provisional; Region: PTZ00424 479435018818 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 479435018819 ATP binding site [chemical binding]; other site 479435018820 Mg++ binding site [ion binding]; other site 479435018821 motif III; other site 479435018822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 479435018823 nucleotide binding region [chemical binding]; other site 479435018824 ATP-binding site [chemical binding]; other site 479435018825 Protein of unknown function (DUF664); Region: DUF664; pfam04978 479435018826 DinB superfamily; Region: DinB_2; pfam12867 479435018827 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 479435018828 active site 479435018829 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435018830 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 479435018831 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 479435018832 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 479435018833 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 479435018834 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 479435018835 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 479435018836 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 479435018837 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 479435018838 dimerization interface [polypeptide binding]; other site 479435018839 Lysine efflux permease [General function prediction only]; Region: COG1279 479435018840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 479435018841 short chain dehydrogenase; Provisional; Region: PRK08303 479435018842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435018843 NAD(P) binding site [chemical binding]; other site 479435018844 active site 479435018845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018846 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435018847 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 479435018848 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 479435018849 EamA-like transporter family; Region: EamA; pfam00892 479435018850 EamA-like transporter family; Region: EamA; pfam00892 479435018851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 479435018852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 479435018853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435018854 Coenzyme A binding pocket [chemical binding]; other site 479435018855 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 479435018856 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435018857 catalytic residue [active] 479435018858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 479435018859 sequence-specific DNA binding site [nucleotide binding]; other site 479435018860 salt bridge; other site 479435018861 Clp protease; Region: CLP_protease; pfam00574 479435018862 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 479435018863 oligomer interface [polypeptide binding]; other site 479435018864 active site residues [active] 479435018865 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 479435018866 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 479435018867 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 479435018868 catalytic residue [active] 479435018869 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 479435018870 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435018871 putative DNA binding site [nucleotide binding]; other site 479435018872 putative Zn2+ binding site [ion binding]; other site 479435018873 AsnC family; Region: AsnC_trans_reg; pfam01037 479435018874 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 479435018875 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 479435018876 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 479435018877 Predicted flavoprotein [General function prediction only]; Region: COG0431 479435018878 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 479435018879 Part of AAA domain; Region: AAA_19; pfam13245 479435018880 Family description; Region: UvrD_C_2; pfam13538 479435018881 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 479435018882 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 479435018883 active site 479435018884 Epoxide hydrolase N terminus; Region: EHN; pfam06441 479435018885 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435018886 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435018887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435018888 active site 479435018889 phosphorylation site [posttranslational modification] 479435018890 intermolecular recognition site; other site 479435018891 dimerization interface [polypeptide binding]; other site 479435018892 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435018893 dimerization interface [polypeptide binding]; other site 479435018894 DNA binding residues [nucleotide binding] 479435018895 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 479435018896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 479435018897 DNA-binding site [nucleotide binding]; DNA binding site 479435018898 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435018899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435018900 homodimer interface [polypeptide binding]; other site 479435018901 catalytic residue [active] 479435018902 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435018903 FAD binding domain; Region: FAD_binding_4; pfam01565 479435018904 Berberine and berberine like; Region: BBE; pfam08031 479435018905 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435018906 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435018907 active site 479435018908 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 479435018909 nudix motif; other site 479435018910 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435018911 active site 479435018912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435018913 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 479435018914 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435018915 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 479435018916 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 479435018917 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 479435018918 Transcriptional regulator [Transcription]; Region: LytR; COG1316 479435018919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435018920 classical (c) SDRs; Region: SDR_c; cd05233 479435018921 NAD(P) binding site [chemical binding]; other site 479435018922 active site 479435018923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435018924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435018925 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 479435018926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435018927 Walker A/P-loop; other site 479435018928 ATP binding site [chemical binding]; other site 479435018929 Q-loop/lid; other site 479435018930 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435018931 ABC transporter signature motif; other site 479435018932 Walker B; other site 479435018933 D-loop; other site 479435018934 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 479435018935 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 479435018936 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; COG0382 479435018937 UbiA prenyltransferase family; Region: UbiA; pfam01040 479435018938 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 479435018939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435018940 putative Zn2+ binding site [ion binding]; other site 479435018941 putative DNA binding site [nucleotide binding]; other site 479435018942 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 479435018943 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 479435018944 putative active site [active] 479435018945 catalytic site [active] 479435018946 putative metal binding site [ion binding]; other site 479435018947 HTH domain; Region: HTH_11; cl17392 479435018948 WYL domain; Region: WYL; pfam13280 479435018949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 479435018950 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 479435018951 Walker A/P-loop; other site 479435018952 ATP binding site [chemical binding]; other site 479435018953 Q-loop/lid; other site 479435018954 ABC transporter signature motif; other site 479435018955 Walker B; other site 479435018956 D-loop; other site 479435018957 H-loop/switch region; other site 479435018958 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 479435018959 metal binding site [ion binding]; metal-binding site 479435018960 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 479435018961 ABC-2 type transporter; Region: ABC2_membrane; cl17235 479435018962 Erythromycin esterase; Region: Erythro_esteras; pfam05139 479435018963 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 479435018964 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 479435018965 TAP-like protein; Region: Abhydrolase_4; pfam08386 479435018966 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 479435018967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435018968 NADH(P)-binding; Region: NAD_binding_10; pfam13460 479435018969 NAD(P) binding site [chemical binding]; other site 479435018970 active site 479435018971 Cupin; Region: Cupin_6; pfam12852 479435018972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435018973 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 479435018974 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 479435018975 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 479435018976 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 479435018977 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 479435018978 Walker A/P-loop; other site 479435018979 ATP binding site [chemical binding]; other site 479435018980 Q-loop/lid; other site 479435018981 ABC transporter signature motif; other site 479435018982 Walker B; other site 479435018983 D-loop; other site 479435018984 H-loop/switch region; other site 479435018985 TOBE domain; Region: TOBE_2; pfam08402 479435018986 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 479435018987 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 479435018988 homotrimer interaction site [polypeptide binding]; other site 479435018989 putative active site [active] 479435018990 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 479435018991 FAD binding domain; Region: FAD_binding_4; pfam01565 479435018992 HTH domain; Region: HTH_11; pfam08279 479435018993 Predicted transcriptional regulator [Transcription]; Region: COG2378 479435018994 WYL domain; Region: WYL; pfam13280 479435018995 Predicted membrane protein [Function unknown]; Region: COG4270 479435018996 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435018997 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435018998 DNA binding residues [nucleotide binding] 479435018999 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 479435019000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435019001 active site 479435019002 phosphorylation site [posttranslational modification] 479435019003 intermolecular recognition site; other site 479435019004 dimerization interface [polypeptide binding]; other site 479435019005 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 479435019006 DNA binding residues [nucleotide binding] 479435019007 dimerization interface [polypeptide binding]; other site 479435019008 Histidine kinase; Region: HisKA_3; pfam07730 479435019009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435019010 ATP binding site [chemical binding]; other site 479435019011 Mg2+ binding site [ion binding]; other site 479435019012 G-X-G motif; other site 479435019013 CAAX protease self-immunity; Region: Abi; pfam02517 479435019014 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 479435019015 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 479435019016 Walker A motif; other site 479435019017 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 479435019018 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 479435019019 Walker B motif; other site 479435019020 DNA binding loops [nucleotide binding] 479435019021 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 479435019022 protein-splicing catalytic site; other site 479435019023 thioester formation/cholesterol transfer; other site 479435019024 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 479435019025 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 479435019026 protein-splicing catalytic site; other site 479435019027 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 479435019028 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 479435019029 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 479435019030 active site 479435019031 HIGH motif; other site 479435019032 dimer interface [polypeptide binding]; other site 479435019033 KMSKS motif; other site 479435019034 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 479435019035 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 479435019036 AAA-like domain; Region: AAA_10; pfam12846 479435019037 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 479435019038 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 479435019039 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 479435019040 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 479435019041 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 479435019042 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 479435019043 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 479435019044 dimer interface [polypeptide binding]; other site 479435019045 ssDNA binding site [nucleotide binding]; other site 479435019046 tetramer (dimer of dimers) interface [polypeptide binding]; other site 479435019047 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 479435019048 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 479435019049 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 479435019050 putative DNA binding site [nucleotide binding]; other site 479435019051 putative Zn2+ binding site [ion binding]; other site 479435019052 AsnC family; Region: AsnC_trans_reg; pfam01037 479435019053 endonuclease IV; Provisional; Region: PRK01060 479435019054 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 479435019055 AP (apurinic/apyrimidinic) site pocket; other site 479435019056 DNA interaction; other site 479435019057 Metal-binding active site; metal-binding site 479435019058 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 479435019059 Beta-lactamase; Region: Beta-lactamase; pfam00144 479435019060 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435019061 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 479435019062 classical (c) SDRs; Region: SDR_c; cd05233 479435019063 NAD(P) binding site [chemical binding]; other site 479435019064 active site 479435019065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435019066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435019067 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 479435019068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 479435019069 Alanine racemase, N-terminal domain; Region: Ala_racemase_N; pfam01168 479435019070 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 479435019071 catalytic residue [active] 479435019072 hypothetical protein; Provisional; Region: PRK08317 479435019073 Methyltransferase domain; Region: Methyltransf_11; pfam08241 479435019074 S-adenosylmethionine binding site [chemical binding]; other site 479435019075 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 479435019076 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 479435019077 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 479435019078 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 479435019079 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 479435019080 Transglycosylase; Region: Transgly; pfam00912 479435019081 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 479435019082 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 479435019083 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435019084 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 479435019085 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 479435019086 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 479435019087 Protein of unknown function DUF72; Region: DUF72; pfam01904 479435019088 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 479435019089 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435019090 NAD(P) binding site [chemical binding]; other site 479435019091 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 479435019092 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 479435019093 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 479435019094 active site 479435019095 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 479435019096 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 479435019097 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435019098 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 479435019099 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 479435019100 homodimer interface [polypeptide binding]; other site 479435019101 putative substrate binding pocket [chemical binding]; other site 479435019102 diiron center [ion binding]; other site 479435019103 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 479435019104 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 479435019105 DNA binding residues [nucleotide binding] 479435019106 Domain of unknown function (DUF4188); Region: DUF4188; pfam13826 479435019107 H+ Antiporter protein; Region: 2A0121; TIGR00900 479435019108 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 479435019109 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 479435019110 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 479435019111 Walker A/P-loop; other site 479435019112 ATP binding site [chemical binding]; other site 479435019113 Q-loop/lid; other site 479435019114 ABC transporter signature motif; other site 479435019115 Walker B; other site 479435019116 D-loop; other site 479435019117 H-loop/switch region; other site 479435019118 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435019119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 479435019120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 479435019121 active site 479435019122 phosphorylation site [posttranslational modification] 479435019123 intermolecular recognition site; other site 479435019124 dimerization interface [polypeptide binding]; other site 479435019125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 479435019126 DNA binding site [nucleotide binding] 479435019127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 479435019128 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 479435019129 dimerization interface [polypeptide binding]; other site 479435019130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 479435019131 dimer interface [polypeptide binding]; other site 479435019132 phosphorylation site [posttranslational modification] 479435019133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 479435019134 ATP binding site [chemical binding]; other site 479435019135 Mg2+ binding site [ion binding]; other site 479435019136 G-X-G motif; other site 479435019137 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 479435019138 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 479435019139 short chain dehydrogenase; Provisional; Region: PRK08251 479435019140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 479435019141 NAD(P) binding site [chemical binding]; other site 479435019142 active site 479435019143 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 479435019144 catalytic core [active] 479435019145 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 479435019146 putative active site [active] 479435019147 putative substrate binding site [chemical binding]; other site 479435019148 ATP binding site [chemical binding]; other site 479435019149 short chain dehydrogenase; Provisional; Region: PRK05650 479435019150 classical (c) SDRs; Region: SDR_c; cd05233 479435019151 NAD(P) binding site [chemical binding]; other site 479435019152 active site 479435019153 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 479435019154 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 479435019155 active site 479435019156 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 479435019157 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 479435019158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 479435019159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 479435019160 DNA binding site [nucleotide binding] 479435019161 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 479435019162 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 479435019163 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 479435019164 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 479435019165 sugar binding site [chemical binding]; other site 479435019166 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 479435019167 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 479435019168 active site 479435019169 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 479435019170 Amidase; Region: Amidase; cl11426 479435019171 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435019172 Coenzyme A binding pocket [chemical binding]; other site 479435019173 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 479435019174 homodimer interface [polypeptide binding]; other site 479435019175 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 479435019176 substrate-cofactor binding pocket; other site 479435019177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435019178 catalytic residue [active] 479435019179 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 479435019180 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 479435019181 active site 479435019182 NTP binding site [chemical binding]; other site 479435019183 metal binding triad [ion binding]; metal-binding site 479435019184 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 479435019185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 479435019186 Zn2+ binding site [ion binding]; other site 479435019187 Mg2+ binding site [ion binding]; other site 479435019188 integral membrane protein MviN; Region: mviN; TIGR01695 479435019189 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 479435019190 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 479435019191 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 479435019192 active site 479435019193 ATP binding site [chemical binding]; other site 479435019194 substrate binding site [chemical binding]; other site 479435019195 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 479435019196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 479435019197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 479435019198 DNA binding residues [nucleotide binding] 479435019199 Putative zinc-finger; Region: zf-HC2; pfam13490 479435019200 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 479435019201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 479435019202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 479435019203 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 479435019204 catalytic residues [active] 479435019205 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 479435019206 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435019207 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 479435019208 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 479435019209 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 479435019210 active site 479435019211 metal binding site [ion binding]; metal-binding site 479435019212 MMPL family; Region: MMPL; pfam03176 479435019213 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 479435019214 Predicted transcriptional regulators [Transcription]; Region: COG1695 479435019215 Transcriptional regulator PadR-like family; Region: PadR; cl17335 479435019216 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 479435019217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 479435019218 Coenzyme A binding pocket [chemical binding]; other site 479435019219 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 479435019220 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 479435019221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 479435019222 homodimer interface [polypeptide binding]; other site 479435019223 catalytic residue [active] 479435019224 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 479435019225 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 479435019226 ATP-grasp domain; Region: ATP-grasp_4; cl17255 479435019227 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 479435019228 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 479435019229 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 479435019230 ParB-like nuclease domain; Region: ParBc; pfam02195 479435019231 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 479435019232 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 479435019233 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 479435019234 Magnesium ion binding site [ion binding]; other site 479435019235 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 479435019236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 479435019237 S-adenosylmethionine binding site [chemical binding]; other site 479435019238 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 479435019239 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 479435019240 G-X-X-G motif; other site 479435019241 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 479435019242 RxxxH motif; other site 479435019243 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 479435019244 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 479435019245 Haemolytic domain; Region: Haemolytic; pfam01809 479435019246 Ribonuclease P; Region: Ribonuclease_P; cl00457 479435019247 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399