-- dump date   	20140619_122037
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
983548000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
983548000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
983548000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548000004	Walker A motif; other site
983548000005	ATP binding site [chemical binding]; other site
983548000006	Walker B motif; other site
983548000007	arginine finger; other site
983548000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
983548000009	DnaA box-binding interface [nucleotide binding]; other site
983548000010	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
983548000011	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
983548000012	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
983548000013	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
983548000014	active site
983548000015	dimer interface [polypeptide binding]; other site
983548000016	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
983548000017	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
983548000018	active site
983548000019	FMN binding site [chemical binding]; other site
983548000020	substrate binding site [chemical binding]; other site
983548000021	3Fe-4S cluster binding site [ion binding]; other site
983548000022	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
983548000023	domain interface; other site
983548000024	Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642
983548000025	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
983548000026	Nitrogen regulatory protein P-II; Region: P-II; smart00938
983548000027	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
983548000028	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
983548000029	Low molecular weight phosphatase family; Region: LMWPc; cd00115
983548000030	active site
983548000031	Uncharacterized subfamily of the tetrapyrrole methylase family similar to ribosomal RNA small subunit methyltransferase I (RsmI); Region: RsmI_like; cd11649
983548000032	putative SAM binding site [chemical binding]; other site
983548000033	homodimer interface [polypeptide binding]; other site
983548000034	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
983548000035	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
983548000036	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
983548000037	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
983548000038	active site
983548000039	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548000040	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548000041	TPR motif; other site
983548000042	binding surface
983548000043	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
983548000044	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
983548000045	Pirin; Region: Pirin; pfam02678
983548000046	Pirin-related protein [General function prediction only]; Region: COG1741
983548000047	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
983548000048	Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388
983548000049	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
983548000050	diaminopimelate decarboxylase; Region: lysA; TIGR01048
983548000051	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
983548000052	active site
983548000053	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
983548000054	substrate binding site [chemical binding]; other site
983548000055	catalytic residues [active]
983548000056	dimer interface [polypeptide binding]; other site
983548000057	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
983548000058	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
983548000059	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
983548000060	PhnA protein; Region: PhnA; pfam03831
983548000061	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
983548000062	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
983548000063	FMN binding site [chemical binding]; other site
983548000064	substrate binding site [chemical binding]; other site
983548000065	putative catalytic residue [active]
983548000066	Peptidase S8 family domain, uncharacterized subfamily 9; Region: Peptidases_S8_9; cd07493
983548000067	active site
983548000068	catalytic triad [active]
983548000069	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548000070	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
983548000071	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
983548000072	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
983548000073	Fasciclin domain; Region: Fasciclin; pfam02469
983548000074	Fasciclin domain; Region: Fasciclin; pfam02469
983548000075	Fasciclin domain; Region: Fasciclin; cl02663
983548000076	Peptidase family M49; Region: Peptidase_M49; pfam03571
983548000077	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818
983548000078	putative hydrophobic ligand binding site [chemical binding]; other site
983548000079	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
983548000080	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
983548000081	Flagellin N-methylase; Region: FliB; pfam03692
983548000082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548000083	S-adenosylmethionine binding site [chemical binding]; other site
983548000084	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
983548000085	Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349
983548000086	active site
983548000087	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548000088	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548000089	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
983548000090	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548000091	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548000092	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
983548000093	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
983548000094	ligand binding site [chemical binding]; other site
983548000095	GMP synthase; Reviewed; Region: guaA; PRK00074
983548000096	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
983548000097	AMP/PPi binding site [chemical binding]; other site
983548000098	candidate oxyanion hole; other site
983548000099	catalytic triad [active]
983548000100	potential glutamine specificity residues [chemical binding]; other site
983548000101	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
983548000102	ATP Binding subdomain [chemical binding]; other site
983548000103	Ligand Binding sites [chemical binding]; other site
983548000104	Dimerization subdomain; other site
983548000105	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
983548000106	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548000107	dimerization interface [polypeptide binding]; other site
983548000108	putative Zn2+ binding site [ion binding]; other site
983548000109	putative DNA binding site [nucleotide binding]; other site
983548000110	AsnC family; Region: AsnC_trans_reg; pfam01037
983548000111	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14185
983548000112	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
983548000113	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
983548000114	homodimer interface [polypeptide binding]; other site
983548000115	NADP binding site [chemical binding]; other site
983548000116	substrate binding site [chemical binding]; other site
983548000117	signal recognition particle protein; Provisional; Region: PRK10867
983548000118	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
983548000119	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
983548000120	P loop; other site
983548000121	GTP binding site [chemical binding]; other site
983548000122	Signal peptide binding domain; Region: SRP_SPB; pfam02978
983548000123	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
983548000124	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
983548000125	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
983548000126	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
983548000127	Ligand binding site; other site
983548000128	Putative Catalytic site; other site
983548000129	DXD motif; other site
983548000130	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
983548000131	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
983548000132	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
983548000133	active site
983548000134	substrate binding site [chemical binding]; other site
983548000135	metal binding site [ion binding]; metal-binding site
983548000136	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
983548000137	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
983548000138	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
983548000139	Walker A/P-loop; other site
983548000140	ATP binding site [chemical binding]; other site
983548000141	Q-loop/lid; other site
983548000142	ABC transporter signature motif; other site
983548000143	Walker B; other site
983548000144	D-loop; other site
983548000145	H-loop/switch region; other site
983548000146	von Willebrand factor type A domain; Region: VWA_2; pfam13519
983548000147	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
983548000148	A subgroup of  the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568
983548000149	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
983548000150	active site
983548000151	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
983548000152	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
983548000153	putative RNA binding site [nucleotide binding]; other site
983548000154	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548000155	S-adenosylmethionine binding site [chemical binding]; other site
983548000156	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
983548000157	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
983548000158	active site
983548000159	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
983548000160	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
983548000161	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
983548000162	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548000163	motif II; other site
983548000164	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
983548000165	active site
983548000166	catalytic residues [active]
983548000167	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
983548000168	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
983548000169	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
983548000170	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
983548000171	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
983548000172	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
983548000173	Tetramer interface [polypeptide binding]; other site
983548000174	active site
983548000175	FMN-binding site [chemical binding]; other site
983548000176	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
983548000177	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
983548000178	putative active site [active]
983548000179	putative metal binding site [ion binding]; other site
983548000180	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
983548000181	FAD binding domain; Region: FAD_binding_4; pfam01565
983548000182	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
983548000183	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
983548000184	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
983548000185	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
983548000186	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
983548000187	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
983548000188	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
983548000189	Beta-lactamase; Region: Beta-lactamase; cl17358
983548000190	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
983548000191	Cysteine-rich domain; Region: CCG; pfam02754
983548000192	Cysteine-rich domain; Region: CCG; pfam02754
983548000193	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548000194	active site
983548000195	motif I; other site
983548000196	motif II; other site
983548000197	4Fe-4S binding domain; Region: Fer4; cl02805
983548000198	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
983548000199	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
983548000200	mce related protein; Region: MCE; pfam02470
983548000201	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
983548000202	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
983548000203	active site
983548000204	metal binding site [ion binding]; metal-binding site
983548000205	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
983548000206	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
983548000207	homotrimer interaction site [polypeptide binding]; other site
983548000208	putative active site [active]
983548000209	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
983548000210	DNA polymerase III, delta subunit; Region: holA; TIGR01128
983548000211	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588
983548000212	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
983548000213	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
983548000214	Probable Catalytic site; other site
983548000215	metal-binding site
983548000216	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548000217	ligand binding site [chemical binding]; other site
983548000218	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
983548000219	Leucine-rich repeats; other site
983548000220	Leucine rich repeat; Region: LRR_8; pfam13855
983548000221	Leucine rich repeat; Region: LRR_8; pfam13855
983548000222	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
983548000223	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548000224	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
983548000225	Part of AAA domain; Region: AAA_19; pfam13245
983548000226	Family description; Region: UvrD_C_2; pfam13538
983548000227	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
983548000228	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548000229	dimer interface [polypeptide binding]; other site
983548000230	putative metal binding site [ion binding]; other site
983548000231	Uncharacterized conserved protein [Function unknown]; Region: COG3586
983548000232	NACHT domain; Region: NACHT; pfam05729
983548000233	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
983548000234	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548000235	S-adenosylmethionine binding site [chemical binding]; other site
983548000236	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
983548000237	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548000238	putative acetyltransferase; Provisional; Region: PRK03624
983548000239	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548000240	Coenzyme A binding pocket [chemical binding]; other site
983548000241	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
983548000242	Predicted acyl esterases [General function prediction only]; Region: COG2936
983548000243	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
983548000244	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548000245	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548000246	catalytic residue [active]
983548000247	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
983548000248	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
983548000249	catalytic triad [active]
983548000250	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
983548000251	active site
983548000252	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
983548000253	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
983548000254	active site
983548000255	metal binding site [ion binding]; metal-binding site
983548000256	nudix motif; other site
983548000257	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548000258	TPR motif; other site
983548000259	TPR repeat; Region: TPR_11; pfam13414
983548000260	binding surface
983548000261	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548000262	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548000263	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548000264	ligand binding site [chemical binding]; other site
983548000265	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548000266	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
983548000267	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
983548000268	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
983548000269	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
983548000270	Parallel beta-helix repeat of pectate lyase; Region: PbH1; pfam13573
983548000271	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548000272	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
983548000273	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
983548000274	G1 box; other site
983548000275	putative GEF interaction site [polypeptide binding]; other site
983548000276	GTP/Mg2+ binding site [chemical binding]; other site
983548000277	Switch I region; other site
983548000278	G2 box; other site
983548000279	G3 box; other site
983548000280	Switch II region; other site
983548000281	G4 box; other site
983548000282	G5 box; other site
983548000283	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
983548000284	Protein of unknown function (DUF2851); Region: DUF2851; pfam11013
983548000285	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
983548000286	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
983548000287	dimer interface [polypeptide binding]; other site
983548000288	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548000289	catalytic residue [active]
983548000290	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
983548000291	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
983548000292	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
983548000293	hexamer interface [polypeptide binding]; other site
983548000294	ligand binding site [chemical binding]; other site
983548000295	putative active site [active]
983548000296	NAD(P) binding site [chemical binding]; other site
983548000297	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
983548000298	Putative esterase; Region: Esterase; pfam00756
983548000299	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
983548000300	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
983548000301	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
983548000302	putative active site [active]
983548000303	putative NTP binding site [chemical binding]; other site
983548000304	putative nucleic acid binding site [nucleotide binding]; other site
983548000305	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
983548000306	Protein of unknown function (DUF1311); Region: DUF1311; cl01530
983548000307	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
983548000308	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
983548000309	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
983548000310	B12 binding site [chemical binding]; other site
983548000311	cobalt ligand [ion binding]; other site
983548000312	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
983548000313	Walker A; other site
983548000314	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
983548000315	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
983548000316	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
983548000317	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
983548000318	putative active site [active]
983548000319	putative substrate binding site [chemical binding]; other site
983548000320	putative cosubstrate binding site; other site
983548000321	catalytic site [active]
983548000322	Protein of unknown function (DUF4197); Region: DUF4197; pfam13852
983548000323	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
983548000324	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
983548000325	intersubunit interface [polypeptide binding]; other site
983548000326	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
983548000327	active site
983548000328	dimer interface [polypeptide binding]; other site
983548000329	peptide chain release factor 1; Validated; Region: prfA; PRK00591
983548000330	PCRF domain; Region: PCRF; pfam03462
983548000331	RF-1 domain; Region: RF-1; pfam00472
983548000332	Phosphoribosylaminoimidazole (AIR) synthetase [Nucleotide transport and metabolism]; Region: PurM; COG0150
983548000333	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
983548000334	dimerization interface [polypeptide binding]; other site
983548000335	ATP binding site [chemical binding]; other site
983548000336	MAC/Perforin domain; Region: MACPF; cl02616
983548000337	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548000338	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548000339	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
983548000340	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548000341	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548000342	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
983548000343	Interdomain contacts; other site
983548000344	Cytokine receptor motif; other site
983548000345	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
983548000346	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
983548000347	Type VIII secretion system (T8SS), CsgF protein; Region: CsgF; cl08082
983548000348	Curli assembly protein CsgE; Region: CsgE; cl08115
983548000349	curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101
983548000350	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
983548000351	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
983548000352	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
983548000353	glutamine synthetase; Region: PLN02284
983548000354	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
983548000355	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
983548000356	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
983548000357	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
983548000358	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
983548000359	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
983548000360	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548000361	Zn2+ binding site [ion binding]; other site
983548000362	Mg2+ binding site [ion binding]; other site
983548000363	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
983548000364	synthetase active site [active]
983548000365	NTP binding site [chemical binding]; other site
983548000366	metal binding site [ion binding]; metal-binding site
983548000367	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
983548000368	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
983548000369	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
983548000370	metal binding site 2 [ion binding]; metal-binding site
983548000371	putative DNA binding helix; other site
983548000372	metal binding site 1 [ion binding]; metal-binding site
983548000373	dimer interface [polypeptide binding]; other site
983548000374	structural Zn2+ binding site [ion binding]; other site
983548000375	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
983548000376	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
983548000377	GDP-binding site [chemical binding]; other site
983548000378	ACT binding site; other site
983548000379	IMP binding site; other site
983548000380	OstA-like protein; Region: OstA_2; pfam13100
983548000381	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
983548000382	Predicted permeases [General function prediction only]; Region: COG0730
983548000383	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
983548000384	N-acetyl-D-glucosamine binding site [chemical binding]; other site
983548000385	catalytic residue [active]
983548000386	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548000387	Predicted esterase [General function prediction only]; Region: COG0400
983548000388	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548000389	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548000390	ligand binding site [chemical binding]; other site
983548000391	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548000392	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548000393	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
983548000394	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
983548000395	nucleotide binding site [chemical binding]; other site
983548000396	NEF interaction site [polypeptide binding]; other site
983548000397	SBD interface [polypeptide binding]; other site
983548000398	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
983548000399	ABC1 family; Region: ABC1; cl17513
983548000400	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
983548000401	active site
983548000402	ATP binding site [chemical binding]; other site
983548000403	substrate binding site [chemical binding]; other site
983548000404	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
983548000405	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
983548000406	dimer interface [polypeptide binding]; other site
983548000407	active site
983548000408	CoA binding pocket [chemical binding]; other site
983548000409	metal-dependent hydrolase; Provisional; Region: PRK13291
983548000410	DinB superfamily; Region: DinB_2; pfam12867
983548000411	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
983548000412	active site
983548000413	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
983548000414	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
983548000415	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
983548000416	active site
983548000417	metal binding site [ion binding]; metal-binding site
983548000418	homotetramer interface [polypeptide binding]; other site
983548000419	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
983548000420	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
983548000421	dimerization interface 3.5A [polypeptide binding]; other site
983548000422	active site
983548000423	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
983548000424	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
983548000425	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
983548000426	Walker A/P-loop; other site
983548000427	ATP binding site [chemical binding]; other site
983548000428	Q-loop/lid; other site
983548000429	ABC transporter signature motif; other site
983548000430	Walker B; other site
983548000431	D-loop; other site
983548000432	H-loop/switch region; other site
983548000433	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
983548000434	cyclase homology domain; Region: CHD; cd07302
983548000435	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
983548000436	nucleotidyl binding site; other site
983548000437	metal binding site [ion binding]; metal-binding site
983548000438	dimer interface [polypeptide binding]; other site
983548000439	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
983548000440	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
983548000441	Double zinc ribbon; Region: DZR; pfam12773
983548000442	zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240
983548000443	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
983548000444	Uncharacterized conserved protein [Function unknown]; Region: COG1624
983548000445	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
983548000446	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
983548000447	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548000448	putative catalytic residue [active]
983548000449	heat shock protein 90; Provisional; Region: PRK05218
983548000450	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
983548000451	YceG-like family; Region: YceG; pfam02618
983548000452	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
983548000453	dimerization interface [polypeptide binding]; other site
983548000454	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
983548000455	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
983548000456	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
983548000457	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
983548000458	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
983548000459	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
983548000460	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
983548000461	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
983548000462	protein binding site [polypeptide binding]; other site
983548000463	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
983548000464	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
983548000465	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
983548000466	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
983548000467	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
983548000468	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548000469	Coenzyme A binding pocket [chemical binding]; other site
983548000470	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
983548000471	peptide chain release factor 2; Validated; Region: prfB; PRK00578
983548000472	PCRF domain; Region: PCRF; pfam03462
983548000473	RF-1 domain; Region: RF-1; pfam00472
983548000474	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
983548000475	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548000476	putative substrate translocation pore; other site
983548000477	Putative cyclase; Region: Cyclase; pfam04199
983548000478	Major royal jelly protein; Region: MRJP; pfam03022
983548000479	Cupin domain; Region: Cupin_2; cl17218
983548000480	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
983548000481	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548000482	ligand binding site [chemical binding]; other site
983548000483	flexible hinge region; other site
983548000484	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
983548000485	CAAX protease self-immunity; Region: Abi; pfam02517
983548000486	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
983548000487	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548000488	putative DNA binding site [nucleotide binding]; other site
983548000489	putative Zn2+ binding site [ion binding]; other site
983548000490	AsnC family; Region: AsnC_trans_reg; pfam01037
983548000491	methionine gamma-lyase; Region: PLN02242
983548000492	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
983548000493	homodimer interface [polypeptide binding]; other site
983548000494	substrate-cofactor binding pocket; other site
983548000495	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548000496	catalytic residue [active]
983548000497	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
983548000498	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
983548000499	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
983548000500	dimer interface [polypeptide binding]; other site
983548000501	decamer (pentamer of dimers) interface [polypeptide binding]; other site
983548000502	catalytic triad [active]
983548000503	peroxidatic and resolving cysteines [active]
983548000504	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548000505	catalytic residues [active]
983548000506	Domain of unknown function (DUF427); Region: DUF427; pfam04248
983548000507	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
983548000508	dimer interface [polypeptide binding]; other site
983548000509	catalytic triad [active]
983548000510	peroxidatic and resolving cysteines [active]
983548000511	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
983548000512	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
983548000513	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
983548000514	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
983548000515	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
983548000516	Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834
983548000517	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
983548000518	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
983548000519	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
983548000520	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
983548000521	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
983548000522	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
983548000523	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
983548000524	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
983548000525	dimerization interface [polypeptide binding]; other site
983548000526	active site
983548000527	Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096
983548000528	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548000529	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
983548000530	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548000531	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548000532	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
983548000533	SmpB-tmRNA interface; other site
983548000534	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
983548000535	catalytic core [active]
983548000536	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
983548000537	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
983548000538	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
983548000539	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
983548000540	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
983548000541	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
983548000542	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
983548000543	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
983548000544	shikimate binding site; other site
983548000545	NAD(P) binding site [chemical binding]; other site
983548000546	Domain of unknown function (DUF368); Region: DUF368; pfam04018
983548000547	Domain of unknown function (DUF368); Region: DUF368; pfam04018
983548000548	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548000549	binding surface
983548000550	TPR motif; other site
983548000551	TPR repeat; Region: TPR_11; pfam13414
983548000552	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548000553	binding surface
983548000554	TPR motif; other site
983548000555	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548000556	binding surface
983548000557	TPR motif; other site
983548000558	TPR repeat; Region: TPR_11; pfam13414
983548000559	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548000560	binding surface
983548000561	TPR repeat; Region: TPR_11; pfam13414
983548000562	TPR motif; other site
983548000563	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548000564	TPR motif; other site
983548000565	binding surface
983548000566	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
983548000567	putative active site [active]
983548000568	Zn binding site [ion binding]; other site
983548000569	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
983548000570	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548000571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548000572	Walker A/P-loop; other site
983548000573	ATP binding site [chemical binding]; other site
983548000574	Q-loop/lid; other site
983548000575	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548000576	ABC transporter signature motif; other site
983548000577	ABC transporter; Region: ABC_tran_2; pfam12848
983548000578	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548000579	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
983548000580	aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824
983548000581	chorismate binding enzyme; Region: Chorismate_bind; cl10555
983548000582	Methyltransferase domain; Region: Methyltransf_26; pfam13659
983548000583	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
983548000584	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
983548000585	metal ion-dependent adhesion site (MIDAS); other site
983548000586	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
983548000587	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
983548000588	homodimer interface [polypeptide binding]; other site
983548000589	metal binding site [ion binding]; metal-binding site
983548000590	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
983548000591	homodimer interface [polypeptide binding]; other site
983548000592	active site
983548000593	putative chemical substrate binding site [chemical binding]; other site
983548000594	metal binding site [ion binding]; metal-binding site
983548000595	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
983548000596	active site
983548000597	catalytic residues [active]
983548000598	metal binding site [ion binding]; metal-binding site
983548000599	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
983548000600	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
983548000601	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
983548000602	trimer interface [polypeptide binding]; other site
983548000603	active site
983548000604	substrate binding site [chemical binding]; other site
983548000605	CoA binding site [chemical binding]; other site
983548000606	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548000607	N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420
983548000608	Substrate binding site; other site
983548000609	metal-binding site
983548000610	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
983548000611	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
983548000612	RNA binding site [nucleotide binding]; other site
983548000613	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
983548000614	RNA binding site [nucleotide binding]; other site
983548000615	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
983548000616	RNA binding site [nucleotide binding]; other site
983548000617	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
983548000618	RNA binding site [nucleotide binding]; other site
983548000619	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
983548000620	RNA binding site [nucleotide binding]; other site
983548000621	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
983548000622	RNA binding site [nucleotide binding]; other site
983548000623	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
983548000624	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548000625	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548000626	catalytic residues [active]
983548000627	Pterin 4 alpha carbinolamine dehydratase; Region: Pterin_4a; pfam01329
983548000628	aromatic arch; other site
983548000629	DCoH dimer interaction site [polypeptide binding]; other site
983548000630	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
983548000631	DCoH tetramer interaction site [polypeptide binding]; other site
983548000632	substrate binding site [chemical binding]; other site
983548000633	hypothetical protein; Provisional; Region: PRK12378
983548000634	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
983548000635	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
983548000636	dimer interface [polypeptide binding]; other site
983548000637	active site
983548000638	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
983548000639	catalytic residues [active]
983548000640	substrate binding site [chemical binding]; other site
983548000641	agmatinase; Region: agmatinase; TIGR01230
983548000642	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
983548000643	putative active site [active]
983548000644	Mn binding site [ion binding]; other site
983548000645	deoxyhypusine synthase; Region: dhys; TIGR00321
983548000646	Deoxyhypusine synthase; Region: DS; cl00826
983548000647	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
983548000648	threonine synthase; Validated; Region: PRK06381
983548000649	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
983548000650	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
983548000651	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
983548000652	active site
983548000653	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
983548000654	cytidylate kinase; Provisional; Region: cmk; PRK00023
983548000655	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
983548000656	CMP-binding site; other site
983548000657	The sites determining sugar specificity; other site
983548000658	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
983548000659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548000660	Walker A motif; other site
983548000661	ATP binding site [chemical binding]; other site
983548000662	Walker B motif; other site
983548000663	arginine finger; other site
983548000664	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
983548000665	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548000666	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548000667	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548000668	DNA binding residues [nucleotide binding]
983548000669	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
983548000670	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
983548000671	Protein of unknown function (DUF2381); Region: DUF2381; cl15442
983548000672	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
983548000673	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
983548000674	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
983548000675	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
983548000676	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548000677	Peptidase family M48; Region: Peptidase_M48; pfam01435
983548000678	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
983548000679	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
983548000680	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
983548000681	trimer interface [polypeptide binding]; other site
983548000682	active site
983548000683	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
983548000684	catalytic site [active]
983548000685	glycogen branching enzyme; Provisional; Region: PRK12313
983548000686	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
983548000687	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
983548000688	active site
983548000689	catalytic site [active]
983548000690	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
983548000691	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
983548000692	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
983548000693	ligand binding site; other site
983548000694	oligomer interface; other site
983548000695	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
983548000696	dimer interface [polypeptide binding]; other site
983548000697	N-terminal domain interface [polypeptide binding]; other site
983548000698	sulfate 1 binding site; other site
983548000699	glycogen synthase; Provisional; Region: glgA; PRK00654
983548000700	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
983548000701	ADP-binding pocket [chemical binding]; other site
983548000702	homodimer interface [polypeptide binding]; other site
983548000703	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
983548000704	SelR domain; Region: SelR; pfam01641
983548000705	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
983548000706	SelR domain; Region: SelR; pfam01641
983548000707	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
983548000708	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548000709	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548000710	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
983548000711	Sulfatase; Region: Sulfatase; cl17466
983548000712	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
983548000713	Dehydroquinase class II; Region: DHquinase_II; pfam01220
983548000714	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
983548000715	trimer interface [polypeptide binding]; other site
983548000716	active site
983548000717	dimer interface [polypeptide binding]; other site
983548000718	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548000719	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
983548000720	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
983548000721	active site
983548000722	Int/Topo IB signature motif; other site
983548000723	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
983548000724	active site
983548000725	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
983548000726	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
983548000727	AMP binding site [chemical binding]; other site
983548000728	active site
983548000729	acyl-activating enzyme (AAE) consensus motif; other site
983548000730	CoA binding site [chemical binding]; other site
983548000731	CAAX protease self-immunity; Region: Abi; pfam02517
983548000732	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
983548000733	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
983548000734	active site
983548000735	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
983548000736	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
983548000737	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
983548000738	homodimer interface [polypeptide binding]; other site
983548000739	substrate-cofactor binding pocket; other site
983548000740	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548000741	catalytic residue [active]
983548000742	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
983548000743	hydrophobic ligand binding site; other site
983548000744	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
983548000745	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
983548000746	active site
983548000747	SdiA-regulated; Region: SdiA-regulated; cd09971
983548000748	putative active site [active]
983548000749	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548000750	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548000751	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
983548000752	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
983548000753	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
983548000754	heme binding site [chemical binding]; other site
983548000755	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
983548000756	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
983548000757	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
983548000758	active site
983548000759	intersubunit interface [polypeptide binding]; other site
983548000760	catalytic residue [active]
983548000761	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
983548000762	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
983548000763	substrate binding site [chemical binding]; other site
983548000764	ATP binding site [chemical binding]; other site
983548000765	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
983548000766	classical (c) SDRs; Region: SDR_c; cd05233
983548000767	NAD(P) binding site [chemical binding]; other site
983548000768	active site
983548000769	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548000770	D-galactonate transporter; Region: 2A0114; TIGR00893
983548000771	putative substrate translocation pore; other site
983548000772	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548000773	Transcriptional regulators [Transcription]; Region: FadR; COG2186
983548000774	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
983548000775	DNA-binding site [nucleotide binding]; DNA binding site
983548000776	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
983548000777	Alginate lyase; Region: Alginate_lyase2; pfam08787
983548000778	FOG: PKD repeat [General function prediction only]; Region: COG3291
983548000779	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
983548000780	Starch-binding associating with outer membrane; Region: SusD-like_3; pfam14322
983548000781	starch binding outer membrane protein SusD; Region: SusD; cd08977
983548000782	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548000783	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548000784	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
983548000785	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548000786	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
983548000787	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
983548000788	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
983548000789	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
983548000790	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
983548000791	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
983548000792	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
983548000793	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
983548000794	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
983548000795	NAD(P) binding site [chemical binding]; other site
983548000796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548000797	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
983548000798	active site
983548000799	phosphorylation site [posttranslational modification]
983548000800	intermolecular recognition site; other site
983548000801	dimerization interface [polypeptide binding]; other site
983548000802	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548000803	Walker A motif; other site
983548000804	ATP binding site [chemical binding]; other site
983548000805	Walker B motif; other site
983548000806	arginine finger; other site
983548000807	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
983548000808	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548000809	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548000810	dimer interface [polypeptide binding]; other site
983548000811	phosphorylation site [posttranslational modification]
983548000812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548000813	ATP binding site [chemical binding]; other site
983548000814	G-X-G motif; other site
983548000815	Protein of unknown function (DUF3124); Region: DUF3124; pfam11322
983548000816	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
983548000817	active site
983548000818	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
983548000819	active site
983548000820	Zn binding site [ion binding]; other site
983548000821	Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263
983548000822	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
983548000823	Cytokine receptor motif; other site
983548000824	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548000825	CARDB; Region: CARDB; pfam07705
983548000826	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
983548000827	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548000828	chitooligosaccharide synthase NodC; Region: nodulat_NodC; TIGR04242
983548000829	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
983548000830	DXD motif; other site
983548000831	threonine dehydratase; Validated; Region: PRK08639
983548000832	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
983548000833	tetramer interface [polypeptide binding]; other site
983548000834	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548000835	catalytic residue [active]
983548000836	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
983548000837	ketol-acid reductoisomerase; Validated; Region: PRK05225
983548000838	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
983548000839	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
983548000840	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
983548000841	Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440
983548000842	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
983548000843	putative valine binding site [chemical binding]; other site
983548000844	dimer interface [polypeptide binding]; other site
983548000845	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
983548000846	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
983548000847	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
983548000848	PYR/PP interface [polypeptide binding]; other site
983548000849	dimer interface [polypeptide binding]; other site
983548000850	TPP binding site [chemical binding]; other site
983548000851	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
983548000852	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
983548000853	TPP-binding site [chemical binding]; other site
983548000854	dimer interface [polypeptide binding]; other site
983548000855	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
983548000856	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
983548000857	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
983548000858	NAD(P) binding site [chemical binding]; other site
983548000859	catalytic residues [active]
983548000860	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
983548000861	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
983548000862	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
983548000863	uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801
983548000864	putative active site [active]
983548000865	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
983548000866	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
983548000867	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548000868	PAS fold; Region: PAS_3; pfam08447
983548000869	putative active site [active]
983548000870	heme pocket [chemical binding]; other site
983548000871	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
983548000872	PAS fold; Region: PAS_3; pfam08447
983548000873	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
983548000874	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548000875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548000876	ATP binding site [chemical binding]; other site
983548000877	Mg2+ binding site [ion binding]; other site
983548000878	G-X-G motif; other site
983548000879	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
983548000880	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
983548000881	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
983548000882	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
983548000883	Predicted acyl esterases [General function prediction only]; Region: COG2936
983548000884	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
983548000885	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
983548000886	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
983548000887	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
983548000888	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548000889	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
983548000890	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
983548000891	Ligand Binding Site [chemical binding]; other site
983548000892	TilS substrate C-terminal domain; Region: TilS_C; smart00977
983548000893	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
983548000894	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
983548000895	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
983548000896	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
983548000897	DNA topoisomerase IB, C-terminal catalytic domain. Topoisomerase I promotes the relaxation of both positive and negative DNA superhelical tension by introducing a transient single-stranded break in duplex DNA. This function is vital for the processes of...; Region: Topo_IB_C; cd00659
983548000898	active site
983548000899	DNA binding site [nucleotide binding]
983548000900	Int/Topo IB signature motif; other site
983548000901	catalytic residues [active]
983548000902	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
983548000903	ATP binding site [chemical binding]; other site
983548000904	active site
983548000905	substrate binding site [chemical binding]; other site
983548000906	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
983548000907	PhoH-like protein; Region: PhoH; pfam02562
983548000908	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
983548000909	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
983548000910	Helix-turn-helix domain; Region: HTH_18; pfam12833
983548000911	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
983548000912	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
983548000913	heme binding pocket [chemical binding]; other site
983548000914	heme ligand [chemical binding]; other site
983548000915	Protein of unknown function (DUF3467); Region: DUF3467; pfam11950
983548000916	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
983548000917	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548000918	active site
983548000919	phosphorylation site [posttranslational modification]
983548000920	intermolecular recognition site; other site
983548000921	Transcription factor/nuclear export subunit protein 2; Region: Tho2; pfam11262
983548000922	Response regulator receiver domain; Region: Response_reg; pfam00072
983548000923	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548000924	active site
983548000925	phosphorylation site [posttranslational modification]
983548000926	intermolecular recognition site; other site
983548000927	dimerization interface [polypeptide binding]; other site
983548000928	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
983548000929	GAF domain; Region: GAF; pfam01590
983548000930	Phytochrome region; Region: PHY; pfam00360
983548000931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548000932	dimer interface [polypeptide binding]; other site
983548000933	phosphorylation site [posttranslational modification]
983548000934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548000935	ATP binding site [chemical binding]; other site
983548000936	Mg2+ binding site [ion binding]; other site
983548000937	G-X-G motif; other site
983548000938	CheB methylesterase; Region: CheB_methylest; pfam01339
983548000939	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
983548000940	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
983548000941	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
983548000942	PAS domain; Region: PAS_10; pfam13596
983548000943	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
983548000944	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548000945	dimer interface [polypeptide binding]; other site
983548000946	phosphorylation site [posttranslational modification]
983548000947	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548000948	ATP binding site [chemical binding]; other site
983548000949	Mg2+ binding site [ion binding]; other site
983548000950	G-X-G motif; other site
983548000951	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
983548000952	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
983548000953	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
983548000954	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
983548000955	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
983548000956	RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998
983548000957	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
983548000958	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
983548000959	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
983548000960	DNA binding site [nucleotide binding]
983548000961	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
983548000962	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
983548000963	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
983548000964	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
983548000965	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
983548000966	RPB11 interaction site [polypeptide binding]; other site
983548000967	RPB12 interaction site [polypeptide binding]; other site
983548000968	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
983548000969	RPB3 interaction site [polypeptide binding]; other site
983548000970	RPB1 interaction site [polypeptide binding]; other site
983548000971	RPB11 interaction site [polypeptide binding]; other site
983548000972	RPB10 interaction site [polypeptide binding]; other site
983548000973	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
983548000974	core dimer interface [polypeptide binding]; other site
983548000975	peripheral dimer interface [polypeptide binding]; other site
983548000976	L10 interface [polypeptide binding]; other site
983548000977	L11 interface [polypeptide binding]; other site
983548000978	putative EF-Tu interaction site [polypeptide binding]; other site
983548000979	putative EF-G interaction site [polypeptide binding]; other site
983548000980	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
983548000981	23S rRNA interface [nucleotide binding]; other site
983548000982	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
983548000983	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
983548000984	mRNA/rRNA interface [nucleotide binding]; other site
983548000985	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
983548000986	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
983548000987	23S rRNA interface [nucleotide binding]; other site
983548000988	L7/L12 interface [polypeptide binding]; other site
983548000989	putative thiostrepton binding site; other site
983548000990	L25 interface [polypeptide binding]; other site
983548000991	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
983548000992	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
983548000993	putative homodimer interface [polypeptide binding]; other site
983548000994	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
983548000995	heterodimer interface [polypeptide binding]; other site
983548000996	homodimer interface [polypeptide binding]; other site
983548000997	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
983548000998	elongation factor Tu; Reviewed; Region: PRK12735
983548000999	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
983548001000	G1 box; other site
983548001001	GEF interaction site [polypeptide binding]; other site
983548001002	GTP/Mg2+ binding site [chemical binding]; other site
983548001003	Switch I region; other site
983548001004	G2 box; other site
983548001005	G3 box; other site
983548001006	Switch II region; other site
983548001007	G4 box; other site
983548001008	G5 box; other site
983548001009	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
983548001010	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
983548001011	Antibiotic Binding Site [chemical binding]; other site
983548001012	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
983548001013	30S subunit binding site; other site
983548001014	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
983548001015	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
983548001016	active site
983548001017	DNA binding site [nucleotide binding]
983548001018	Int/Topo IB signature motif; other site
983548001019	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
983548001020	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
983548001021	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
983548001022	active site
983548001023	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
983548001024	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
983548001025	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
983548001026	Ion channel; Region: Ion_trans_2; pfam07885
983548001027	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
983548001028	TrkA-N domain; Region: TrkA_N; pfam02254
983548001029	TrkA-C domain; Region: TrkA_C; pfam02080
983548001030	PspC domain; Region: PspC; cl00864
983548001031	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
983548001032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548001033	ATP binding site [chemical binding]; other site
983548001034	putative Mg++ binding site [ion binding]; other site
983548001035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548001036	nucleotide binding region [chemical binding]; other site
983548001037	ATP-binding site [chemical binding]; other site
983548001038	RQC domain; Region: RQC; pfam09382
983548001039	HRDC domain; Region: HRDC; pfam00570
983548001040	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
983548001041	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
983548001042	putative active site [active]
983548001043	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
983548001044	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
983548001045	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
983548001046	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
983548001047	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
983548001048	Walker A/P-loop; other site
983548001049	ATP binding site [chemical binding]; other site
983548001050	Q-loop/lid; other site
983548001051	ABC transporter signature motif; other site
983548001052	Walker B; other site
983548001053	D-loop; other site
983548001054	H-loop/switch region; other site
983548001055	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
983548001056	active site
983548001057	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
983548001058	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
983548001059	Histidine kinase; Region: His_kinase; pfam06580
983548001060	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
983548001061	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548001062	active site
983548001063	phosphorylation site [posttranslational modification]
983548001064	intermolecular recognition site; other site
983548001065	dimerization interface [polypeptide binding]; other site
983548001066	LytTr DNA-binding domain; Region: LytTR; smart00850
983548001067	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
983548001068	GTP cyclohydrolase I; Provisional; Region: PLN03044
983548001069	active site
983548001070	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
983548001071	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548001072	active site
983548001073	HIGH motif; other site
983548001074	nucleotide binding site [chemical binding]; other site
983548001075	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
983548001076	KMSKS motif; other site
983548001077	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
983548001078	tRNA binding surface [nucleotide binding]; other site
983548001079	anticodon binding site; other site
983548001080	Haemolytic domain; Region: Haemolytic; pfam01809
983548001081	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
983548001082	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
983548001083	Domain of unknown function (DUF4295); Region: DUF4295; pfam14128
983548001084	ribosomal protein L33; Region: rpl33; CHL00104
983548001085	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
983548001086	competence damage-inducible protein A; Provisional; Region: PRK00549
983548001087	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
983548001088	putative MPT binding site; other site
983548001089	Competence-damaged protein; Region: CinA; pfam02464
983548001090	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
983548001091	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
983548001092	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
983548001093	DNA polymerase III subunit epsilon; Validated; Region: PRK06309
983548001094	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
983548001095	active site
983548001096	catalytic site [active]
983548001097	substrate binding site [chemical binding]; other site
983548001098	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
983548001099	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
983548001100	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
983548001101	E3 interaction surface; other site
983548001102	lipoyl attachment site [posttranslational modification]; other site
983548001103	e3 binding domain; Region: E3_binding; pfam02817
983548001104	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
983548001105	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548001106	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
983548001107	Probable Catalytic site; other site
983548001108	metal-binding site
983548001109	recombination protein RecR; Reviewed; Region: recR; PRK00076
983548001110	RecR protein; Region: RecR; pfam02132
983548001111	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
983548001112	putative active site [active]
983548001113	putative metal-binding site [ion binding]; other site
983548001114	tetramer interface [polypeptide binding]; other site
983548001115	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
983548001116	Methyltransferase domain; Region: Methyltransf_18; pfam12847
983548001117	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
983548001118	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
983548001119	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
983548001120	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
983548001121	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
983548001122	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
983548001123	Uncharacterized conserved protein [Function unknown]; Region: COG4198
983548001124	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
983548001125	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
983548001126	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
983548001127	catalytic residue [active]
983548001128	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
983548001129	active site
983548001130	catalytic site [active]
983548001131	substrate binding site [chemical binding]; other site
983548001132	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
983548001133	GIY-YIG motif/motif A; other site
983548001134	active site
983548001135	catalytic site [active]
983548001136	putative DNA binding site [nucleotide binding]; other site
983548001137	metal binding site [ion binding]; metal-binding site
983548001138	Ion transport protein; Region: Ion_trans; pfam00520
983548001139	Ion channel; Region: Ion_trans_2; pfam07885
983548001140	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
983548001141	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
983548001142	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
983548001143	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
983548001144	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548001145	active site
983548001146	phosphorylation site [posttranslational modification]
983548001147	intermolecular recognition site; other site
983548001148	dimerization interface [polypeptide binding]; other site
983548001149	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
983548001150	DNA binding site [nucleotide binding]
983548001151	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548001152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548001153	dimer interface [polypeptide binding]; other site
983548001154	phosphorylation site [posttranslational modification]
983548001155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548001156	ATP binding site [chemical binding]; other site
983548001157	Mg2+ binding site [ion binding]; other site
983548001158	G-X-G motif; other site
983548001159	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
983548001160	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
983548001161	CoA-binding site [chemical binding]; other site
983548001162	ATP-binding [chemical binding]; other site
983548001163	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
983548001164	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
983548001165	active site
983548001166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548001167	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
983548001168	NAD(P) binding site [chemical binding]; other site
983548001169	active site
983548001170	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
983548001171	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
983548001172	Walker A/P-loop; other site
983548001173	ATP binding site [chemical binding]; other site
983548001174	Q-loop/lid; other site
983548001175	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
983548001176	Q-loop/lid; other site
983548001177	ABC transporter signature motif; other site
983548001178	Walker B; other site
983548001179	D-loop; other site
983548001180	H-loop/switch region; other site
983548001181	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
983548001182	Flavoprotein; Region: Flavoprotein; pfam02441
983548001183	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
983548001184	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192
983548001185	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
983548001186	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
983548001187	dihydrodipicolinate synthase; Region: dapA; TIGR00674
983548001188	dimer interface [polypeptide binding]; other site
983548001189	active site
983548001190	catalytic residue [active]
983548001191	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
983548001192	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
983548001193	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
983548001194	active site
983548001195	metal binding site [ion binding]; metal-binding site
983548001196	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
983548001197	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
983548001198	nucleotide binding pocket [chemical binding]; other site
983548001199	K-X-D-G motif; other site
983548001200	catalytic site [active]
983548001201	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
983548001202	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
983548001203	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
983548001204	Dimer interface [polypeptide binding]; other site
983548001205	BRCT sequence motif; other site
983548001206	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
983548001207	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
983548001208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548001209	S-adenosylmethionine binding site [chemical binding]; other site
983548001210	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
983548001211	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548001212	Coenzyme A binding pocket [chemical binding]; other site
983548001213	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
983548001214	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
983548001215	catalytic motif [active]
983548001216	Zn binding site [ion binding]; other site
983548001217	RibD C-terminal domain; Region: RibD_C; pfam01872
983548001218	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
983548001219	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
983548001220	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
983548001221	The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176
983548001222	Tic20-like protein; Region: Tic20; pfam09685
983548001223	Predicted transcriptional regulators [Transcription]; Region: COG1695
983548001224	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
983548001225	PspC domain; Region: PspC; pfam04024
983548001226	SnoaL-like domain; Region: SnoaL_3; pfam13474
983548001227	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
983548001228	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
983548001229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548001230	non-specific DNA binding site [nucleotide binding]; other site
983548001231	salt bridge; other site
983548001232	sequence-specific DNA binding site [nucleotide binding]; other site
983548001233	PspA/IM30 family; Region: PspA_IM30; pfam04012
983548001234	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
983548001235	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
983548001236	ATPase involved in DNA repair; Region: DUF3686; pfam12458
983548001237	AAA domain; Region: AAA_22; pfam13401
983548001238	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548001239	Walker A motif; other site
983548001240	ATP binding site [chemical binding]; other site
983548001241	Walker B motif; other site
983548001242	arginine finger; other site
983548001243	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
983548001244	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548001245	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548001246	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
983548001247	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
983548001248	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
983548001249	Cytochrome c; Region: Cytochrom_C; pfam00034
983548001250	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
983548001251	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
983548001252	P-loop; other site
983548001253	Magnesium ion binding site [ion binding]; other site
983548001254	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
983548001255	Magnesium ion binding site [ion binding]; other site
983548001256	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
983548001257	ParB-like nuclease domain; Region: ParBc; pfam02195
983548001258	dihydrodipicolinate reductase; Provisional; Region: PRK00048
983548001259	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
983548001260	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
983548001261	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
983548001262	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
983548001263	Catalytic site [active]
983548001264	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
983548001265	WbqC-like protein family; Region: WbqC; pfam08889
983548001266	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; uncharacterized family 2; Region: EEP-2; cd09084
983548001267	putative catalytic site [active]
983548001268	putative metal binding site [ion binding]; other site
983548001269	putative phosphate binding site [ion binding]; other site
983548001270	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
983548001271	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
983548001272	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
983548001273	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548001274	ATP binding site [chemical binding]; other site
983548001275	Mg2+ binding site [ion binding]; other site
983548001276	G-X-G motif; other site
983548001277	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
983548001278	ATP binding site [chemical binding]; other site
983548001279	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
983548001280	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
983548001281	homopentamer interface [polypeptide binding]; other site
983548001282	active site
983548001283	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
983548001284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548001285	binding surface
983548001286	TPR motif; other site
983548001287	recombination protein F; Reviewed; Region: recF; PRK00064
983548001288	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548001289	Walker A/P-loop; other site
983548001290	ATP binding site [chemical binding]; other site
983548001291	Q-loop/lid; other site
983548001292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548001293	ABC transporter signature motif; other site
983548001294	Walker B; other site
983548001295	D-loop; other site
983548001296	H-loop/switch region; other site
983548001297	Protein of unknown function (DUF721); Region: DUF721; pfam05258
983548001298	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
983548001299	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
983548001300	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548001301	active site
983548001302	HIGH motif; other site
983548001303	nucleotide binding site [chemical binding]; other site
983548001304	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
983548001305	KMSK motif region; other site
983548001306	tRNA binding surface [nucleotide binding]; other site
983548001307	DALR anticodon binding domain; Region: DALR_1; smart00836
983548001308	anticodon binding site; other site
983548001309	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
983548001310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548001311	NAD(P) binding site [chemical binding]; other site
983548001312	active site
983548001313	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
983548001314	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
983548001315	Amidinotransferase; Region: Amidinotransf; pfam02274
983548001316	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
983548001317	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
983548001318	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548001319	Cation transport protein; Region: TrkH; cl17365
983548001320	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
983548001321	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
983548001322	TrkA-N domain; Region: TrkA_N; pfam02254
983548001323	TrkA-C domain; Region: TrkA_C; pfam02080
983548001324	TrkA-N domain; Region: TrkA_N; pfam02254
983548001325	TrkA-C domain; Region: TrkA_C; pfam02080
983548001326	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
983548001327	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548001328	S-adenosylmethionine binding site [chemical binding]; other site
983548001329	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548001330	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
983548001331	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
983548001332	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
983548001333	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548001334	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548001335	TPR motif; other site
983548001336	binding surface
983548001337	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548001338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548001339	dimer interface [polypeptide binding]; other site
983548001340	phosphorylation site [posttranslational modification]
983548001341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548001342	ATP binding site [chemical binding]; other site
983548001343	Mg2+ binding site [ion binding]; other site
983548001344	G-X-G motif; other site
983548001345	Response regulator receiver domain; Region: Response_reg; pfam00072
983548001346	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548001347	active site
983548001348	phosphorylation site [posttranslational modification]
983548001349	intermolecular recognition site; other site
983548001350	dimerization interface [polypeptide binding]; other site
983548001351	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
983548001352	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
983548001353	active site
983548001354	intersubunit interface [polypeptide binding]; other site
983548001355	zinc binding site [ion binding]; other site
983548001356	Na+ binding site [ion binding]; other site
983548001357	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
983548001358	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
983548001359	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
983548001360	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
983548001361	substrate binding pocket [chemical binding]; other site
983548001362	chain length determination region; other site
983548001363	substrate-Mg2+ binding site; other site
983548001364	catalytic residues [active]
983548001365	aspartate-rich region 1; other site
983548001366	active site lid residues [active]
983548001367	aspartate-rich region 2; other site
983548001368	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
983548001369	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548001370	FeS/SAM binding site; other site
983548001371	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
983548001372	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548001373	catalytic residue [active]
983548001374	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
983548001375	tetramer interface [polypeptide binding]; other site
983548001376	active site
983548001377	Mg2+/Mn2+ binding site [ion binding]; other site
983548001378	active site
983548001379	metal binding site [ion binding]; metal-binding site
983548001380	isocitrate lyase; Region: PLN02892
983548001381	malate synthase A; Region: malate_syn_A; TIGR01344
983548001382	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
983548001383	active site
983548001384	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
983548001385	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548001386	non-specific DNA binding site [nucleotide binding]; other site
983548001387	salt bridge; other site
983548001388	sequence-specific DNA binding site [nucleotide binding]; other site
983548001389	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
983548001390	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
983548001391	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
983548001392	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
983548001393	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
983548001394	hinge; other site
983548001395	active site
983548001396	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
983548001397	homodimer interface [polypeptide binding]; other site
983548001398	metal binding site [ion binding]; metal-binding site
983548001399	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
983548001400	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
983548001401	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
983548001402	Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969
983548001403	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
983548001404	putative active site [active]
983548001405	dimerization interface [polypeptide binding]; other site
983548001406	putative tRNAtyr binding site [nucleotide binding]; other site
983548001407	GTPase RsgA; Reviewed; Region: PRK00098
983548001408	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
983548001409	RNA binding site [nucleotide binding]; other site
983548001410	homodimer interface [polypeptide binding]; other site
983548001411	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
983548001412	GTPase/Zn-binding domain interface [polypeptide binding]; other site
983548001413	GTP/Mg2+ binding site [chemical binding]; other site
983548001414	G4 box; other site
983548001415	G5 box; other site
983548001416	G1 box; other site
983548001417	Switch I region; other site
983548001418	G2 box; other site
983548001419	G3 box; other site
983548001420	Switch II region; other site
983548001421	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
983548001422	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
983548001423	Chorismate mutase type II; Region: CM_2; smart00830
983548001424	prephenate dehydrogenase; Validated; Region: PRK08507
983548001425	Prephenate dehydrogenase; Region: PDH; pfam02153
983548001426	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
983548001427	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
983548001428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548001429	homodimer interface [polypeptide binding]; other site
983548001430	catalytic residue [active]
983548001431	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
983548001432	Prephenate dehydratase; Region: PDT; pfam00800
983548001433	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
983548001434	putative L-Phe binding site [chemical binding]; other site
983548001435	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
983548001436	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548001437	Walker A/P-loop; other site
983548001438	ATP binding site [chemical binding]; other site
983548001439	Q-loop/lid; other site
983548001440	ABC transporter signature motif; other site
983548001441	Walker B; other site
983548001442	D-loop; other site
983548001443	H-loop/switch region; other site
983548001444	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
983548001445	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
983548001446	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
983548001447	16S/18S rRNA binding site [nucleotide binding]; other site
983548001448	S13e-L30e interaction site [polypeptide binding]; other site
983548001449	25S rRNA binding site [nucleotide binding]; other site
983548001450	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
983548001451	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
983548001452	RNase E interface [polypeptide binding]; other site
983548001453	trimer interface [polypeptide binding]; other site
983548001454	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
983548001455	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
983548001456	RNase E interface [polypeptide binding]; other site
983548001457	trimer interface [polypeptide binding]; other site
983548001458	active site
983548001459	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cd00105
983548001460	nucleic acid binding region [nucleotide binding]; other site
983548001461	G-X-X-G motif; other site
983548001462	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
983548001463	RNA binding site [nucleotide binding]; other site
983548001464	domain interface; other site
983548001465	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
983548001466	GIY-YIG motif/motif A; other site
983548001467	putative active site [active]
983548001468	putative metal binding site [ion binding]; other site
983548001469	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
983548001470	Response regulator receiver domain; Region: Response_reg; pfam00072
983548001471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548001472	active site
983548001473	phosphorylation site [posttranslational modification]
983548001474	intermolecular recognition site; other site
983548001475	dimerization interface [polypeptide binding]; other site
983548001476	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
983548001477	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
983548001478	Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176
983548001479	putative homodimer interface [polypeptide binding]; other site
983548001480	putative active site [active]
983548001481	catalytic site [active]
983548001482	CAAX protease self-immunity; Region: Abi; pfam02517
983548001483	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
983548001484	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
983548001485	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548001486	S-adenosylmethionine binding site [chemical binding]; other site
983548001487	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548001488	dimerization interface [polypeptide binding]; other site
983548001489	putative DNA binding site [nucleotide binding]; other site
983548001490	putative Zn2+ binding site [ion binding]; other site
983548001491	Low molecular weight phosphatase family; Region: LMWPc; cl00105
983548001492	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
983548001493	arsenical-resistance protein; Region: acr3; TIGR00832
983548001494	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
983548001495	nudix motif; other site
983548001496	BetR domain; Region: BetR; pfam08667
983548001497	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
983548001498	Zn binding site [ion binding]; other site
983548001499	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548001500	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548001501	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
983548001502	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
983548001503	active site pocket [active]
983548001504	oxyanion hole [active]
983548001505	catalytic triad [active]
983548001506	active site nucleophile [active]
983548001507	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548001508	Predicted acetyltransferase [General function prediction only]; Region: COG2388
983548001509	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
983548001510	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
983548001511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548001512	Coenzyme A binding pocket [chemical binding]; other site
983548001513	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
983548001514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548001515	binding surface
983548001516	TPR motif; other site
983548001517	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
983548001518	GTPase CgtA; Reviewed; Region: obgE; PRK12299
983548001519	GTP1/OBG; Region: GTP1_OBG; pfam01018
983548001520	Obg GTPase; Region: Obg; cd01898
983548001521	G1 box; other site
983548001522	GTP/Mg2+ binding site [chemical binding]; other site
983548001523	Switch I region; other site
983548001524	G2 box; other site
983548001525	G3 box; other site
983548001526	Switch II region; other site
983548001527	G4 box; other site
983548001528	G5 box; other site
983548001529	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548001530	active site
983548001531	adenylate kinase; Reviewed; Region: adk; PRK00279
983548001532	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
983548001533	AMP-binding site [chemical binding]; other site
983548001534	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
983548001535	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
983548001536	ATP-grasp domain; Region: ATP-grasp; pfam02222
983548001537	AIR carboxylase; Region: AIRC; pfam00731
983548001538	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
983548001539	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
983548001540	active site
983548001541	Zn binding site [ion binding]; other site
983548001542	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548001543	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
983548001544	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548001545	dimerization interface [polypeptide binding]; other site
983548001546	putative DNA binding site [nucleotide binding]; other site
983548001547	putative Zn2+ binding site [ion binding]; other site
983548001548	TIGR01777 family protein; Region: yfcH
983548001549	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548001550	NAD(P) binding site [chemical binding]; other site
983548001551	active site
983548001552	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548001553	RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1
983548001554	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548001555	DNA binding residues [nucleotide binding]
983548001556	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
983548001557	glycine dehydrogenase; Provisional; Region: PRK05367
983548001558	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
983548001559	tetramer interface [polypeptide binding]; other site
983548001560	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548001561	catalytic residue [active]
983548001562	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
983548001563	tetramer interface [polypeptide binding]; other site
983548001564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548001565	catalytic residue [active]
983548001566	3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332
983548001567	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
983548001568	dimer interface [polypeptide binding]; other site
983548001569	active site
983548001570	CoA binding pocket [chemical binding]; other site
983548001571	Methyltransferase domain; Region: Methyltransf_23; pfam13489
983548001572	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
983548001573	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548001574	active site
983548001575	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
983548001576	dimer interface [polypeptide binding]; other site
983548001577	Alkaline phosphatase homologues; Region: alkPPc; smart00098
983548001578	active site
983548001579	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
983548001580	Permease; Region: Permease; pfam02405
983548001581	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
983548001582	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
983548001583	Walker A/P-loop; other site
983548001584	ATP binding site [chemical binding]; other site
983548001585	Q-loop/lid; other site
983548001586	ABC transporter signature motif; other site
983548001587	Walker B; other site
983548001588	D-loop; other site
983548001589	H-loop/switch region; other site
983548001590	Major Facilitator Superfamily; Region: MFS_1; pfam07690
983548001591	Domain of unknown function (DUF389); Region: DUF389; pfam04087
983548001592	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
983548001593	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
983548001594	Substrate binding site; other site
983548001595	SprT homologues; Region: SprT; cl01182
983548001596	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
983548001597	classical (c) SDRs; Region: SDR_c; cd05233
983548001598	NAD(P) binding site [chemical binding]; other site
983548001599	active site
983548001600	M28 Zn-Peptidase IAP aminopeptidase may contain PA domain insert; Region: M28_like_5; cd08021
983548001601	Peptidase family M28; Region: Peptidase_M28; pfam04389
983548001602	metal binding site [ion binding]; metal-binding site
983548001603	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
983548001604	E3 interaction surface; other site
983548001605	lipoyl attachment site [posttranslational modification]; other site
983548001606	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
983548001607	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
983548001608	E3 interaction surface; other site
983548001609	lipoyl attachment site [posttranslational modification]; other site
983548001610	e3 binding domain; Region: E3_binding; pfam02817
983548001611	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
983548001612	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
983548001613	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
983548001614	tetramer interface [polypeptide binding]; other site
983548001615	TPP-binding site [chemical binding]; other site
983548001616	heterodimer interface [polypeptide binding]; other site
983548001617	phosphorylation loop region [posttranslational modification]
983548001618	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
983548001619	active site
983548001620	catalytic motif [active]
983548001621	Zn binding site [ion binding]; other site
983548001622	Peptidase C25 family N-terminal domain, found in Arg-gingipain (Rgp), Lys-gingipain (Kgp) and related proteins; Region: Peptidase_C25_N; cd02258
983548001623	active site
983548001624	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
983548001625	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
983548001626	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
983548001627	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
983548001628	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
983548001629	glycerol kinase; Provisional; Region: glpK; PRK00047
983548001630	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
983548001631	N- and C-terminal domain interface [polypeptide binding]; other site
983548001632	active site
983548001633	MgATP binding site [chemical binding]; other site
983548001634	catalytic site [active]
983548001635	metal binding site [ion binding]; metal-binding site
983548001636	glycerol binding site [chemical binding]; other site
983548001637	homotetramer interface [polypeptide binding]; other site
983548001638	homodimer interface [polypeptide binding]; other site
983548001639	FBP binding site [chemical binding]; other site
983548001640	protein IIAGlc interface [polypeptide binding]; other site
983548001641	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
983548001642	putative transporter; Provisional; Region: PRK10484
983548001643	uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328
983548001644	Na binding site [ion binding]; other site
983548001645	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
983548001646	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
983548001647	NAD binding site [chemical binding]; other site
983548001648	homodimer interface [polypeptide binding]; other site
983548001649	active site
983548001650	substrate binding site [chemical binding]; other site
983548001651	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
983548001652	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
983548001653	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
983548001654	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
983548001655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548001656	Walker A/P-loop; other site
983548001657	ATP binding site [chemical binding]; other site
983548001658	Q-loop/lid; other site
983548001659	ABC transporter signature motif; other site
983548001660	Walker B; other site
983548001661	D-loop; other site
983548001662	H-loop/switch region; other site
983548001663	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
983548001664	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
983548001665	Outer membrane efflux protein; Region: OEP; pfam02321
983548001666	Outer membrane efflux protein; Region: OEP; pfam02321
983548001667	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
983548001668	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
983548001669	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
983548001670	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
983548001671	Zn binding site [ion binding]; other site
983548001672	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
983548001673	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
983548001674	Walker A/P-loop; other site
983548001675	ATP binding site [chemical binding]; other site
983548001676	Q-loop/lid; other site
983548001677	ABC transporter signature motif; other site
983548001678	Walker B; other site
983548001679	D-loop; other site
983548001680	H-loop/switch region; other site
983548001681	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
983548001682	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
983548001683	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
983548001684	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
983548001685	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
983548001686	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
983548001687	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
983548001688	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
983548001689	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
983548001690	NAD(P) binding pocket [chemical binding]; other site
983548001691	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
983548001692	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
983548001693	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
983548001694	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
983548001695	FAD binding site [chemical binding]; other site
983548001696	homotetramer interface [polypeptide binding]; other site
983548001697	substrate binding pocket [chemical binding]; other site
983548001698	catalytic base [active]
983548001699	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cd00091
983548001700	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
983548001701	active site
983548001702	substrate binding site [chemical binding]; other site
983548001703	Mg2+ binding site [ion binding]; other site
983548001704	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
983548001705	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
983548001706	dimer interface [polypeptide binding]; other site
983548001707	conserved gate region; other site
983548001708	putative PBP binding loops; other site
983548001709	ABC-ATPase subunit interface; other site
983548001710	C-terminal peptidase (prc); Region: prc; TIGR00225
983548001711	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
983548001712	protein binding site [polypeptide binding]; other site
983548001713	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
983548001714	Catalytic dyad [active]
983548001715	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
983548001716	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
983548001717	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
983548001718	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
983548001719	NlpC/P60 family; Region: NLPC_P60; pfam00877
983548001720	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
983548001721	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
983548001722	Competence protein; Region: Competence; pfam03772
983548001723	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
983548001724	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
983548001725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548001726	putative substrate translocation pore; other site
983548001727	POT family; Region: PTR2; cl17359
983548001728	Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930
983548001729	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548001730	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548001731	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
983548001732	homodimer interface [polypeptide binding]; other site
983548001733	catalytic residues [active]
983548001734	NAD binding site [chemical binding]; other site
983548001735	substrate binding pocket [chemical binding]; other site
983548001736	flexible flap; other site
983548001737	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
983548001738	SurA N-terminal domain; Region: SurA_N_3; cl07813
983548001739	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
983548001740	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
983548001741	SpoVG; Region: SpoVG; cl00915
983548001742	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
983548001743	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
983548001744	Domain of unknown function DUF21; Region: DUF21; pfam01595
983548001745	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
983548001746	Transporter associated domain; Region: CorC_HlyC; smart01091
983548001747	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
983548001748	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548001749	binding surface
983548001750	TPR motif; other site
983548001751	Type III pantothenate kinase; Region: Pan_kinase; cl17198
983548001752	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
983548001753	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
983548001754	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548001755	substrate binding pocket [chemical binding]; other site
983548001756	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548001757	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
983548001758	active site
983548001759	catalytic residues [active]
983548001760	alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169
983548001761	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
983548001762	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548001763	FeS/SAM binding site; other site
983548001764	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
983548001765	Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492
983548001766	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548001767	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548001768	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
983548001769	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548001770	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
983548001771	starch binding outer membrane protein SusD; Region: SusD; cd08977
983548001772	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
983548001773	Na binding site [ion binding]; other site
983548001774	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
983548001775	active site
983548001776	metal binding site [ion binding]; metal-binding site
983548001777	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
983548001778	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548001779	active site residue [active]
983548001780	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
983548001781	purine nucleoside phosphorylase; Provisional; Region: PRK08202
983548001782	Methyltransferase domain; Region: Methyltransf_31; pfam13847
983548001783	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548001784	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
983548001785	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
983548001786	Protein of unknown function, DUF547; Region: DUF547; pfam04784
983548001787	Protein of unknown function, DUF547; Region: DUF547; pfam04784
983548001788	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
983548001789	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
983548001790	Probable Catalytic site; other site
983548001791	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
983548001792	dimer interface [polypeptide binding]; other site
983548001793	FMN binding site [chemical binding]; other site
983548001794	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
983548001795	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
983548001796	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548001797	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548001798	dimer interface [polypeptide binding]; other site
983548001799	phosphorylation site [posttranslational modification]
983548001800	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548001801	ATP binding site [chemical binding]; other site
983548001802	Mg2+ binding site [ion binding]; other site
983548001803	G-X-G motif; other site
983548001804	Response regulator receiver domain; Region: Response_reg; pfam00072
983548001805	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548001806	active site
983548001807	phosphorylation site [posttranslational modification]
983548001808	intermolecular recognition site; other site
983548001809	dimerization interface [polypeptide binding]; other site
983548001810	Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775
983548001811	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
983548001812	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548001813	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
983548001814	Protein of unknown function, DUF547; Region: DUF547; pfam04784
983548001815	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
983548001816	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548001817	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548001818	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
983548001819	4Fe-4S binding domain; Region: Fer4_5; pfam12801
983548001820	Domain of unknown function (DUF4328); Region: DUF4328; pfam14219
983548001821	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
983548001822	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548001823	Coenzyme A binding pocket [chemical binding]; other site
983548001824	DinB superfamily; Region: DinB_2; pfam12867
983548001825	DinB family; Region: DinB; cl17821
983548001826	Protein of unknown function (DUF4240); Region: DUF4240; pfam14024
983548001827	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
983548001828	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
983548001829	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
983548001830	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
983548001831	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
983548001832	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
983548001833	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
983548001834	carboxyltransferase (CT) interaction site; other site
983548001835	biotinylation site [posttranslational modification]; other site
983548001836	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
983548001837	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
983548001838	dimer interface [polypeptide binding]; other site
983548001839	active site
983548001840	CoA binding pocket [chemical binding]; other site
983548001841	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
983548001842	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
983548001843	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
983548001844	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
983548001845	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
983548001846	Lumazine binding domain; Region: Lum_binding; pfam00677
983548001847	Lumazine binding domain; Region: Lum_binding; pfam00677
983548001848	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548001849	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
983548001850	dimer interface [polypeptide binding]; other site
983548001851	substrate binding site [chemical binding]; other site
983548001852	metal binding site [ion binding]; metal-binding site
983548001853	Ribosome-binding factor A; Region: RBFA; pfam02033
983548001854	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
983548001855	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
983548001856	FtsX-like permease family; Region: FtsX; pfam02687
983548001857	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
983548001858	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
983548001859	FMN binding site [chemical binding]; other site
983548001860	active site
983548001861	catalytic residues [active]
983548001862	substrate binding site [chemical binding]; other site
983548001863	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548001864	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548001865	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548001866	GTP-binding protein LepA; Provisional; Region: PRK05433
983548001867	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
983548001868	G1 box; other site
983548001869	putative GEF interaction site [polypeptide binding]; other site
983548001870	GTP/Mg2+ binding site [chemical binding]; other site
983548001871	Switch I region; other site
983548001872	G2 box; other site
983548001873	G3 box; other site
983548001874	Switch II region; other site
983548001875	G4 box; other site
983548001876	G5 box; other site
983548001877	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
983548001878	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
983548001879	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
983548001880	Class I aldolases; Region: Aldolase_Class_I; cd00945
983548001881	catalytic residue [active]
983548001882	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
983548001883	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
983548001884	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
983548001885	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
983548001886	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
983548001887	active site residue [active]
983548001888	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
983548001889	active site residue [active]
983548001890	Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513
983548001891	active site
983548001892	dimer interface [polypeptide binding]; other site
983548001893	catalytic nucleophile [active]
983548001894	DNA polymerase I; Provisional; Region: PRK05755
983548001895	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
983548001896	active site
983548001897	metal binding site 1 [ion binding]; metal-binding site
983548001898	putative 5' ssDNA interaction site; other site
983548001899	metal binding site 3; metal-binding site
983548001900	metal binding site 2 [ion binding]; metal-binding site
983548001901	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
983548001902	putative DNA binding site [nucleotide binding]; other site
983548001903	putative metal binding site [ion binding]; other site
983548001904	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
983548001905	active site
983548001906	catalytic site [active]
983548001907	substrate binding site [chemical binding]; other site
983548001908	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
983548001909	active site
983548001910	DNA binding site [nucleotide binding]
983548001911	catalytic site [active]
983548001912	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
983548001913	putative ligand binding site [chemical binding]; other site
983548001914	Protein of unknown function (DUF3374); Region: DUF3374; cl11904
983548001915	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
983548001916	23S rRNA interface [nucleotide binding]; other site
983548001917	L3 interface [polypeptide binding]; other site
983548001918	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
983548001919	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
983548001920	rRNA interaction site [nucleotide binding]; other site
983548001921	S8 interaction site; other site
983548001922	putative laminin-1 binding site; other site
983548001923	elongation factor Ts; Provisional; Region: tsf; PRK09377
983548001924	UBA/TS-N domain; Region: UBA; pfam00627
983548001925	Elongation factor TS; Region: EF_TS; pfam00889
983548001926	Elongation factor TS; Region: EF_TS; pfam00889
983548001927	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
983548001928	putative nucleotide binding site [chemical binding]; other site
983548001929	uridine monophosphate binding site [chemical binding]; other site
983548001930	homohexameric interface [polypeptide binding]; other site
983548001931	ribosome recycling factor; Reviewed; Region: frr; PRK00083
983548001932	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
983548001933	hinge region; other site
983548001934	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
983548001935	Protein export membrane protein; Region: SecD_SecF; cl14618
983548001936	Uncharacterized conserved protein [Function unknown]; Region: COG5135
983548001937	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxase_2; pfam12766
983548001938	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
983548001939	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
983548001940	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
983548001941	putative dimer interface [polypeptide binding]; other site
983548001942	putative anticodon binding site; other site
983548001943	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
983548001944	homodimer interface [polypeptide binding]; other site
983548001945	motif 1; other site
983548001946	motif 2; other site
983548001947	active site
983548001948	motif 3; other site
983548001949	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
983548001950	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
983548001951	Histidine kinase; Region: HisKA_3; pfam07730
983548001952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548001953	ATP binding site [chemical binding]; other site
983548001954	Mg2+ binding site [ion binding]; other site
983548001955	G-X-G motif; other site
983548001956	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
983548001957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548001958	active site
983548001959	phosphorylation site [posttranslational modification]
983548001960	intermolecular recognition site; other site
983548001961	dimerization interface [polypeptide binding]; other site
983548001962	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
983548001963	DNA binding residues [nucleotide binding]
983548001964	dimerization interface [polypeptide binding]; other site
983548001965	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
983548001966	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
983548001967	Na binding site [ion binding]; other site
983548001968	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
983548001969	glutaminase A; Region: Gln_ase; TIGR03814
983548001970	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
983548001971	Transcriptional regulators [Transcription]; Region: MarR; COG1846
983548001972	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
983548001973	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
983548001974	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
983548001975	S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711
983548001976	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
983548001977	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
983548001978	homodimer interface [polypeptide binding]; other site
983548001979	substrate-cofactor binding pocket; other site
983548001980	catalytic residue [active]
983548001981	Peptidase family M48; Region: Peptidase_M48; pfam01435
983548001982	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
983548001983	phosphoglyceromutase; Provisional; Region: PRK05434
983548001984	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548001985	catalytic residues [active]
983548001986	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548001987	catalytic residues [active]
983548001988	Protein of unknown function (DUF805); Region: DUF805; pfam05656
983548001989	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
983548001990	active site
983548001991	Methyltransferase domain; Region: Methyltransf_23; pfam13489
983548001992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548001993	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
983548001994	ApbE family; Region: ApbE; pfam02424
983548001995	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
983548001996	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
983548001997	catalytic loop [active]
983548001998	iron binding site [ion binding]; other site
983548001999	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
983548002000	FAD binding pocket [chemical binding]; other site
983548002001	FAD binding motif [chemical binding]; other site
983548002002	phosphate binding motif [ion binding]; other site
983548002003	beta-alpha-beta structure motif; other site
983548002004	NAD binding pocket [chemical binding]; other site
983548002005	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
983548002006	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
983548002007	FMN-binding domain; Region: FMN_bind; cl01081
983548002008	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
983548002009	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
983548002010	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
983548002011	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
983548002012	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
983548002013	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
983548002014	Protein of unknown function (DUF3667); Region: DUF3667; pfam12412
983548002015	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
983548002016	NRDE protein; Region: NRDE; cl01315
983548002017	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
983548002018	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
983548002019	Glutamate binding site [chemical binding]; other site
983548002020	NAD binding site [chemical binding]; other site
983548002021	catalytic residues [active]
983548002022	GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895
983548002023	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
983548002024	CysD dimerization site [polypeptide binding]; other site
983548002025	G1 box; other site
983548002026	putative GEF interaction site [polypeptide binding]; other site
983548002027	GTP/Mg2+ binding site [chemical binding]; other site
983548002028	Switch I region; other site
983548002029	G2 box; other site
983548002030	G3 box; other site
983548002031	Switch II region; other site
983548002032	G4 box; other site
983548002033	G5 box; other site
983548002034	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
983548002035	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
983548002036	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
983548002037	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
983548002038	Active Sites [active]
983548002039	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
983548002040	Active Sites [active]
983548002041	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
983548002042	Rrf2 family protein; Region: rrf2_super; TIGR00738
983548002043	Transcriptional regulator; Region: Rrf2; pfam02082
983548002044	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
983548002045	FAD binding site [chemical binding]; other site
983548002046	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
983548002047	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
983548002048	substrate binding pocket [chemical binding]; other site
983548002049	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
983548002050	B12 binding site [chemical binding]; other site
983548002051	cobalt ligand [ion binding]; other site
983548002052	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
983548002053	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
983548002054	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
983548002055	O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133
983548002056	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
983548002057	homodimer interface [polypeptide binding]; other site
983548002058	substrate-cofactor binding pocket; other site
983548002059	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548002060	catalytic residue [active]
983548002061	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
983548002062	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
983548002063	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
983548002064	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
983548002065	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
983548002066	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
983548002067	homodimer interface [polypeptide binding]; other site
983548002068	substrate-cofactor binding pocket; other site
983548002069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548002070	catalytic residue [active]
983548002071	S-adenosylmethionine synthetase; Validated; Region: PRK05250
983548002072	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
983548002073	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
983548002074	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
983548002075	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547
983548002076	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548002077	GLPGLI family protein; Region: GLPGLI; TIGR01200
983548002078	GLPGLI family protein; Region: GLPGLI; TIGR01200
983548002079	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548002080	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548002081	dimer interface [polypeptide binding]; other site
983548002082	phosphorylation site [posttranslational modification]
983548002083	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002084	ATP binding site [chemical binding]; other site
983548002085	Mg2+ binding site [ion binding]; other site
983548002086	G-X-G motif; other site
983548002087	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
983548002088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002089	active site
983548002090	phosphorylation site [posttranslational modification]
983548002091	intermolecular recognition site; other site
983548002092	dimerization interface [polypeptide binding]; other site
983548002093	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
983548002094	DNA binding site [nucleotide binding]
983548002095	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
983548002096	heme-binding site [chemical binding]; other site
983548002097	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
983548002098	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
983548002099	Substrate-binding site [chemical binding]; other site
983548002100	Substrate specificity [chemical binding]; other site
983548002101	Uncharacterized conserved protein [Function unknown]; Region: COG4850
983548002102	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
983548002103	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
983548002104	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548002105	putative catalytic residues [active]
983548002106	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
983548002107	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
983548002108	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
983548002109	dimer interface [polypeptide binding]; other site
983548002110	substrate binding site [chemical binding]; other site
983548002111	metal binding sites [ion binding]; metal-binding site
983548002112	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002113	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
983548002114	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
983548002115	alpha subunit interface [polypeptide binding]; other site
983548002116	TPP binding site [chemical binding]; other site
983548002117	heterodimer interface [polypeptide binding]; other site
983548002118	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
983548002119	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
983548002120	Ligand binding site [chemical binding]; other site
983548002121	Electron transfer flavoprotein domain; Region: ETF; pfam01012
983548002122	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
983548002123	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
983548002124	Ligand Binding Site [chemical binding]; other site
983548002125	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
983548002126	Bifunctional nuclease; Region: DNase-RNase; pfam02577
983548002127	UvrB/uvrC motif; Region: UVR; pfam02151
983548002128	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
983548002129	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
983548002130	Nucleoside recognition; Region: Gate; pfam07670
983548002131	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
983548002132	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002133	thymidylate synthase; Reviewed; Region: thyA; PRK01827
983548002134	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
983548002135	dimerization interface [polypeptide binding]; other site
983548002136	active site
983548002137	ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440
983548002138	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
983548002139	dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438
983548002140	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
983548002141	Domain of unknown function (DUF427); Region: DUF427; pfam04248
983548002142	N-terminal Early set domain associated with the catalytic domain of isoamylase-like (also called glycogen 6-glucanohydrolase) proteins; Region: E_set_Isoamylase_like_N; cd07184
983548002143	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
983548002144	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548002145	2TM domain; Region: 2TM; pfam13239
983548002146	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
983548002147	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
983548002148	folate binding site [chemical binding]; other site
983548002149	NADP+ binding site [chemical binding]; other site
983548002150	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
983548002151	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
983548002152	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
983548002153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548002154	non-specific DNA binding site [nucleotide binding]; other site
983548002155	salt bridge; other site
983548002156	sequence-specific DNA binding site [nucleotide binding]; other site
983548002157	Predicted transcriptional regulator [Transcription]; Region: COG2932
983548002158	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
983548002159	Catalytic site [active]
983548002160	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
983548002161	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
983548002162	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
983548002163	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
983548002164	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
983548002165	inhibitor-cofactor binding pocket; inhibition site
983548002166	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548002167	catalytic residue [active]
983548002168	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
983548002169	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548002170	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
983548002171	active site
983548002172	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548002173	binding surface
983548002174	TPR motif; other site
983548002175	TPR repeat; Region: TPR_11; pfam13414
983548002176	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548002177	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548002178	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548002179	ligand binding site [chemical binding]; other site
983548002180	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548002181	CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225
983548002182	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548002183	Catalytic GIY-YIG domain of yeast structure-specific endonuclease subunit SLX1 and its homologs; Region: GIY-YIG_SLX1_like; cd10449
983548002184	GIY-YIG motif/motif A; other site
983548002185	putative active site [active]
983548002186	putative metal binding site [ion binding]; other site
983548002187	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
983548002188	MutS domain I; Region: MutS_I; pfam01624
983548002189	MutS domain II; Region: MutS_II; pfam05188
983548002190	MutS domain III; Region: MutS_III; pfam05192
983548002191	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
983548002192	Walker A/P-loop; other site
983548002193	ATP binding site [chemical binding]; other site
983548002194	Q-loop/lid; other site
983548002195	ABC transporter signature motif; other site
983548002196	Walker B; other site
983548002197	D-loop; other site
983548002198	H-loop/switch region; other site
983548002199	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548002200	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002201	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548002202	starch binding outer membrane protein SusD; Region: SusD; cd08977
983548002203	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
983548002204	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
983548002205	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
983548002206	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
983548002207	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
983548002208	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548002209	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
983548002210	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
983548002211	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
983548002212	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
983548002213	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
983548002214	substrate binding pocket [chemical binding]; other site
983548002215	chain length determination region; other site
983548002216	substrate-Mg2+ binding site; other site
983548002217	catalytic residues [active]
983548002218	aspartate-rich region 1; other site
983548002219	active site lid residues [active]
983548002220	aspartate-rich region 2; other site
983548002221	CotH protein; Region: CotH; pfam08757
983548002222	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
983548002223	catalytic center binding site [active]
983548002224	ATP binding site [chemical binding]; other site
983548002225	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
983548002226	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
983548002227	Substrate-binding site [chemical binding]; other site
983548002228	Substrate specificity [chemical binding]; other site
983548002229	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592
983548002230	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
983548002231	Patatin-like phospholipase; Region: Patatin; pfam01734
983548002232	active site
983548002233	nucleophile elbow; other site
983548002234	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002235	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548002236	GTP-binding protein Der; Reviewed; Region: PRK00093
983548002237	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
983548002238	G1 box; other site
983548002239	GTP/Mg2+ binding site [chemical binding]; other site
983548002240	Switch I region; other site
983548002241	G2 box; other site
983548002242	Switch II region; other site
983548002243	G3 box; other site
983548002244	G4 box; other site
983548002245	G5 box; other site
983548002246	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
983548002247	G1 box; other site
983548002248	GTP/Mg2+ binding site [chemical binding]; other site
983548002249	Switch I region; other site
983548002250	G2 box; other site
983548002251	G3 box; other site
983548002252	Switch II region; other site
983548002253	G4 box; other site
983548002254	G5 box; other site
983548002255	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
983548002256	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
983548002257	GH3 auxin-responsive promoter; Region: GH3; pfam03321
983548002258	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
983548002259	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
983548002260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548002261	Walker A motif; other site
983548002262	ATP binding site [chemical binding]; other site
983548002263	Walker B motif; other site
983548002264	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
983548002265	Clp protease; Region: CLP_protease; pfam00574
983548002266	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
983548002267	oligomer interface [polypeptide binding]; other site
983548002268	active site residues [active]
983548002269	trigger factor; Provisional; Region: tig; PRK01490
983548002270	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
983548002271	catalytic triad [active]
983548002272	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
983548002273	PGAP1-like protein; Region: PGAP1; pfam07819
983548002274	acyl-CoA esterase; Provisional; Region: PRK10673
983548002275	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
983548002276	active site
983548002277	hydrophilic channel; other site
983548002278	dimerization interface [polypeptide binding]; other site
983548002279	catalytic residues [active]
983548002280	active site lid [active]
983548002281	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
983548002282	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK01911
983548002283	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
983548002284	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548002285	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
983548002286	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
983548002287	catalytic residue [active]
983548002288	putative FPP diphosphate  binding site; other site
983548002289	putative FPP binding hydrophobic cleft; other site
983548002290	dimer interface [polypeptide binding]; other site
983548002291	putative IPP diphosphate binding site; other site
983548002292	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
983548002293	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
983548002294	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
983548002295	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
983548002296	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
983548002297	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548002298	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
983548002299	periplasmic chaperone; Provisional; Region: PRK10780
983548002300	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
983548002301	glutamate racemase; Provisional; Region: PRK00865
983548002302	Response regulator receiver domain; Region: Response_reg; pfam00072
983548002303	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002304	active site
983548002305	phosphorylation site [posttranslational modification]
983548002306	intermolecular recognition site; other site
983548002307	dimerization interface [polypeptide binding]; other site
983548002308	LytTr DNA-binding domain; Region: LytTR; smart00850
983548002309	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002310	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548002311	binding surface
983548002312	TPR motif; other site
983548002313	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548002314	binding surface
983548002315	TPR motif; other site
983548002316	Histidine kinase; Region: His_kinase; pfam06580
983548002317	Histidine kinase-like ATPases; Region: HATPase_c; smart00387
983548002318	ATP binding site [chemical binding]; other site
983548002319	Mg2+ binding site [ion binding]; other site
983548002320	G-X-G motif; other site
983548002321	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
983548002322	metal ion-dependent adhesion site (MIDAS); other site
983548002323	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
983548002324	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548002325	ligand binding site [chemical binding]; other site
983548002326	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548002327	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
983548002328	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
983548002329	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
983548002330	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
983548002331	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
983548002332	active site
983548002333	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
983548002334	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548002335	S-adenosylmethionine binding site [chemical binding]; other site
983548002336	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
983548002337	RimM N-terminal domain; Region: RimM; pfam01782
983548002338	Cadherin repeat-like domain; Region: CA_like; cl15786
983548002339	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14521
983548002340	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
983548002341	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
983548002342	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
983548002343	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
983548002344	active site
983548002345	catalytic site [active]
983548002346	substrate binding site [chemical binding]; other site
983548002347	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
983548002348	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
983548002349	active site
983548002350	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
983548002351	generic binding surface II; other site
983548002352	generic binding surface I; other site
983548002353	TPR repeat; Region: TPR_11; pfam13414
983548002354	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
983548002355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002356	ATP binding site [chemical binding]; other site
983548002357	Mg2+ binding site [ion binding]; other site
983548002358	G-X-G motif; other site
983548002359	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
983548002360	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
983548002361	active site
983548002362	phosphorylation site [posttranslational modification]
983548002363	intermolecular recognition site; other site
983548002364	dimerization interface [polypeptide binding]; other site
983548002365	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
983548002366	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
983548002367	E3 interaction surface; other site
983548002368	lipoyl attachment site [posttranslational modification]; other site
983548002369	e3 binding domain; Region: E3_binding; pfam02817
983548002370	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
983548002371	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
983548002372	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
983548002373	TPP-binding site [chemical binding]; other site
983548002374	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
983548002375	YciI-like protein; Reviewed; Region: PRK12866
983548002376	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
983548002377	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
983548002378	active site
983548002379	substrate binding site [chemical binding]; other site
983548002380	coenzyme B12 binding site [chemical binding]; other site
983548002381	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
983548002382	B12 binding site [chemical binding]; other site
983548002383	cobalt ligand [ion binding]; other site
983548002384	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
983548002385	heterodimer interface [polypeptide binding]; other site
983548002386	substrate interaction site [chemical binding]; other site
983548002387	Septum formation initiator; Region: DivIC; cl17659
983548002388	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
983548002389	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
983548002390	Sugar specificity; other site
983548002391	Pyrimidine base specificity; other site
983548002392	ATP-binding site [chemical binding]; other site
983548002393	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
983548002394	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
983548002395	HflX GTPase family; Region: HflX; cd01878
983548002396	G1 box; other site
983548002397	GTP/Mg2+ binding site [chemical binding]; other site
983548002398	Switch I region; other site
983548002399	G2 box; other site
983548002400	G3 box; other site
983548002401	Switch II region; other site
983548002402	G4 box; other site
983548002403	G5 box; other site
983548002404	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
983548002405	putative catalytic site [active]
983548002406	putative metal binding site [ion binding]; other site
983548002407	putative phosphate binding site [ion binding]; other site
983548002408	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002409	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548002410	TonB dependent receptor; Region: TonB_dep_Rec; pfam00593
983548002411	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
983548002412	putative catalytic site [active]
983548002413	putative metal binding site [ion binding]; other site
983548002414	putative phosphate binding site [ion binding]; other site
983548002415	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548002416	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548002417	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
983548002418	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
983548002419	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
983548002420	active site
983548002421	dimer interface [polypeptide binding]; other site
983548002422	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
983548002423	dimer interface [polypeptide binding]; other site
983548002424	active site
983548002425	putative peptidase; Provisional; Region: PRK11649
983548002426	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548002427	Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994
983548002428	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
983548002429	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
983548002430	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
983548002431	dimer interface [polypeptide binding]; other site
983548002432	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
983548002433	active site
983548002434	Fe binding site [ion binding]; other site
983548002435	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
983548002436	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548002437	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
983548002438	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
983548002439	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
983548002440	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
983548002441	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
983548002442	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
983548002443	Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129
983548002444	dimer interface [polypeptide binding]; other site
983548002445	NADP binding site [chemical binding]; other site
983548002446	catalytic residues [active]
983548002447	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
983548002448	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
983548002449	inhibitor site; inhibition site
983548002450	active site
983548002451	dimer interface [polypeptide binding]; other site
983548002452	catalytic residue [active]
983548002453	Cupin domain; Region: Cupin_2; pfam07883
983548002454	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
983548002455	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
983548002456	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
983548002457	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002458	active site
983548002459	phosphorylation site [posttranslational modification]
983548002460	intermolecular recognition site; other site
983548002461	CHASE3 domain; Region: CHASE3; pfam05227
983548002462	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548002463	dimer interface [polypeptide binding]; other site
983548002464	phosphorylation site [posttranslational modification]
983548002465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002466	ATP binding site [chemical binding]; other site
983548002467	Mg2+ binding site [ion binding]; other site
983548002468	G-X-G motif; other site
983548002469	Response regulator receiver domain; Region: Response_reg; pfam00072
983548002470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002471	active site
983548002472	phosphorylation site [posttranslational modification]
983548002473	intermolecular recognition site; other site
983548002474	dimerization interface [polypeptide binding]; other site
983548002475	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
983548002476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548002477	Walker A/P-loop; other site
983548002478	ATP binding site [chemical binding]; other site
983548002479	Q-loop/lid; other site
983548002480	ABC transporter signature motif; other site
983548002481	Walker B; other site
983548002482	D-loop; other site
983548002483	H-loop/switch region; other site
983548002484	Protein of unknown function (DUF419); Region: DUF419; pfam04237
983548002485	AAA domain; Region: AAA_33; pfam13671
983548002486	AAA domain; Region: AAA_17; pfam13207
983548002487	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
983548002488	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002489	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
983548002490	thiamine phosphate binding site [chemical binding]; other site
983548002491	active site
983548002492	pyrophosphate binding site [ion binding]; other site
983548002493	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548002494	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548002495	catalytic residues [active]
983548002496	acetyl-CoA synthetase; Provisional; Region: PRK00174
983548002497	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
983548002498	active site
983548002499	CoA binding site [chemical binding]; other site
983548002500	acyl-activating enzyme (AAE) consensus motif; other site
983548002501	AMP binding site [chemical binding]; other site
983548002502	acetate binding site [chemical binding]; other site
983548002503	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548002504	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548002505	TPR motif; other site
983548002506	binding surface
983548002507	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548002508	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548002509	dimer interface [polypeptide binding]; other site
983548002510	phosphorylation site [posttranslational modification]
983548002511	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002512	ATP binding site [chemical binding]; other site
983548002513	Mg2+ binding site [ion binding]; other site
983548002514	G-X-G motif; other site
983548002515	Response regulator receiver domain; Region: Response_reg; pfam00072
983548002516	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002517	active site
983548002518	phosphorylation site [posttranslational modification]
983548002519	intermolecular recognition site; other site
983548002520	dimerization interface [polypeptide binding]; other site
983548002521	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
983548002522	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
983548002523	dimer interface [polypeptide binding]; other site
983548002524	ssDNA binding site [nucleotide binding]; other site
983548002525	tetramer (dimer of dimers) interface [polypeptide binding]; other site
983548002526	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
983548002527	carboxyltransferase (CT) interaction site; other site
983548002528	biotinylation site [posttranslational modification]; other site
983548002529	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
983548002530	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
983548002531	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
983548002532	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
983548002533	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
983548002534	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
983548002535	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
983548002536	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
983548002537	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548002538	ATP binding site [chemical binding]; other site
983548002539	putative Mg++ binding site [ion binding]; other site
983548002540	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548002541	nucleotide binding region [chemical binding]; other site
983548002542	ATP-binding site [chemical binding]; other site
983548002543	RQC domain; Region: RQC; pfam09382
983548002544	HRDC domain; Region: HRDC; pfam00570
983548002545	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
983548002546	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
983548002547	transmembrane helices; other site
983548002548	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
983548002549	dimerization interface [polypeptide binding]; other site
983548002550	active site
983548002551	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548002552	S-adenosylmethionine binding site [chemical binding]; other site
983548002553	Domain of unknown function (DUF4154); Region: DUF4154; pfam13689
983548002554	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548002555	dimer interface [polypeptide binding]; other site
983548002556	phosphorylation site [posttranslational modification]
983548002557	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002558	ATP binding site [chemical binding]; other site
983548002559	Mg2+ binding site [ion binding]; other site
983548002560	G-X-G motif; other site
983548002561	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002562	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548002563	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548002564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002565	active site
983548002566	phosphorylation site [posttranslational modification]
983548002567	intermolecular recognition site; other site
983548002568	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
983548002569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002570	active site
983548002571	phosphorylation site [posttranslational modification]
983548002572	intermolecular recognition site; other site
983548002573	dimerization interface [polypeptide binding]; other site
983548002574	Cupin-like domain; Region: Cupin_8; pfam13621
983548002575	biotin synthase; Region: bioB; TIGR00433
983548002576	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548002577	FeS/SAM binding site; other site
983548002578	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
983548002579	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
983548002580	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
983548002581	active site
983548002582	Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695
983548002583	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
983548002584	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
983548002585	inhibitor-cofactor binding pocket; inhibition site
983548002586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548002587	catalytic residue [active]
983548002588	AAA domain; Region: AAA_26; pfam13500
983548002589	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
983548002590	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
983548002591	Small acid-soluble spore protein H family; Region: SspH; cl06949
983548002592	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
983548002593	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
983548002594	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548002595	catalytic residue [active]
983548002596	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
983548002597	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
983548002598	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
983548002599	protein binding site [polypeptide binding]; other site
983548002600	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
983548002601	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548002602	non-specific DNA binding site [nucleotide binding]; other site
983548002603	salt bridge; other site
983548002604	sequence-specific DNA binding site [nucleotide binding]; other site
983548002605	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
983548002606	gamma subunit interface [polypeptide binding]; other site
983548002607	LBP interface [polypeptide binding]; other site
983548002608	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
983548002609	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
983548002610	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
983548002611	alpha subunit interaction interface [polypeptide binding]; other site
983548002612	Walker A motif; other site
983548002613	ATP binding site [chemical binding]; other site
983548002614	Walker B motif; other site
983548002615	inhibitor binding site; inhibition site
983548002616	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
983548002617	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
983548002618	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
983548002619	glutaminase active site [active]
983548002620	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
983548002621	dimer interface [polypeptide binding]; other site
983548002622	active site
983548002623	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
983548002624	dimer interface [polypeptide binding]; other site
983548002625	active site
983548002626	Domain of unknown function (DUF4270); Region: DUF4270; pfam14092
983548002627	Starch synthase catalytic domain; Region: Glyco_transf_5; pfam08323
983548002628	pantoate--beta-alanine ligase; Region: panC; TIGR00018
983548002629	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548002630	active site
983548002631	nucleotide binding site [chemical binding]; other site
983548002632	HIGH motif; other site
983548002633	KMSKS motif; other site
983548002634	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
983548002635	tetramerization interface [polypeptide binding]; other site
983548002636	active site
983548002637	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
983548002638	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
983548002639	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548002640	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
983548002641	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
983548002642	DNA binding residues [nucleotide binding]
983548002643	dimerization interface [polypeptide binding]; other site
983548002644	DNA repair protein RadA; Provisional; Region: PRK11823
983548002645	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
983548002646	Walker A motif/ATP binding site; other site
983548002647	ATP binding site [chemical binding]; other site
983548002648	Walker B motif; other site
983548002649	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
983548002650	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
983548002651	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548002652	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
983548002653	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
983548002654	active site
983548002655	catalytic tetrad [active]
983548002656	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548002657	ligand binding site [chemical binding]; other site
983548002658	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
983548002659	putative active site [active]
983548002660	putative catalytic site [active]
983548002661	putative DNA binding site [nucleotide binding]; other site
983548002662	putative phosphate binding site [ion binding]; other site
983548002663	metal binding site A [ion binding]; metal-binding site
983548002664	putative AP binding site [nucleotide binding]; other site
983548002665	putative metal binding site B [ion binding]; other site
983548002666	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268
983548002667	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548002668	glycyl-tRNA synthetase; Provisional; Region: PRK04173
983548002669	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
983548002670	motif 1; other site
983548002671	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
983548002672	active site
983548002673	motif 2; other site
983548002674	motif 3; other site
983548002675	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
983548002676	anticodon binding site; other site
983548002677	Phage maturation protein; Region: Phage_mat-A; cl17797
983548002678	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
983548002679	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548002680	active site
983548002681	Bacterial Ig-like domain; Region: Big_5; pfam13205
983548002682	C-N hydrolase family amidase; Provisional; Region: PRK10438
983548002683	Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575
983548002684	putative active site [active]
983548002685	catalytic triad [active]
983548002686	dimer interface [polypeptide binding]; other site
983548002687	multimer interface [polypeptide binding]; other site
983548002688	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
983548002689	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548002690	ligand binding site [chemical binding]; other site
983548002691	flexible hinge region; other site
983548002692	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
983548002693	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
983548002694	metal binding triad; other site
983548002695	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
983548002696	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
983548002697	active site
983548002698	catalytic site [active]
983548002699	substrate binding site [chemical binding]; other site
983548002700	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
983548002701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
983548002702	motif II; other site
983548002703	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548002704	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
983548002705	Ankyrin repeats (many copies); Region: Ank_5; pfam13857
983548002706	Protein of unknown function (DUF1440); Region: DUF1440; cl01380
983548002707	methionine aminotransferase; Validated; Region: PRK09082
983548002708	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
983548002709	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548002710	homodimer interface [polypeptide binding]; other site
983548002711	catalytic residue [active]
983548002712	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
983548002713	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
983548002714	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
983548002715	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
983548002716	acyl-activating enzyme (AAE) consensus motif; other site
983548002717	putative AMP binding site [chemical binding]; other site
983548002718	putative active site [active]
983548002719	putative CoA binding site [chemical binding]; other site
983548002720	hypothetical protein; Provisional; Region: PRK08201
983548002721	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_1; cd05678
983548002722	putative metal binding site [ion binding]; other site
983548002723	putative dimer interface [polypeptide binding]; other site
983548002724	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
983548002725	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
983548002726	dimer interface [polypeptide binding]; other site
983548002727	active site
983548002728	heme binding site [chemical binding]; other site
983548002729	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
983548002730	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
983548002731	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
983548002732	C-terminal peptidase (prc); Region: prc; TIGR00225
983548002733	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
983548002734	protein binding site [polypeptide binding]; other site
983548002735	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
983548002736	Catalytic dyad [active]
983548002737	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
983548002738	catalytic motif [active]
983548002739	Zn binding site [ion binding]; other site
983548002740	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
983548002741	tellurium resistance terB-like protein; Region: terB_like; cl11965
983548002742	metal binding site [ion binding]; metal-binding site
983548002743	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
983548002744	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548002745	dimer interface [polypeptide binding]; other site
983548002746	phosphorylation site [posttranslational modification]
983548002747	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002748	ATP binding site [chemical binding]; other site
983548002749	Mg2+ binding site [ion binding]; other site
983548002750	G-X-G motif; other site
983548002751	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
983548002752	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002753	active site
983548002754	phosphorylation site [posttranslational modification]
983548002755	intermolecular recognition site; other site
983548002756	dimerization interface [polypeptide binding]; other site
983548002757	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
983548002758	Ras-related in brain (Rab) family of small guanosine triphosphatases (GTPases); Region: Rab; cd00154
983548002759	Rab subfamily motif 1 (RabSF1); other site
983548002760	G1 box; other site
983548002761	GTP/Mg2+ binding site [chemical binding]; other site
983548002762	Rab subfamily motif 2 (RabSF2); other site
983548002763	Switch I region; other site
983548002764	G2 box; other site
983548002765	effector interaction site; other site
983548002766	GDI interaction site; other site
983548002767	Rab family motif 1 (RabF1); other site
983548002768	GEF interaction site [polypeptide binding]; other site
983548002769	Rab family motif 2 (RabF2); other site
983548002770	G3 box; other site
983548002771	Switch II region; other site
983548002772	Rab family motif 3 (RabF3); other site
983548002773	Rab family motif 4 (RabF4); other site
983548002774	Rab family motif 5 (RabF5); other site
983548002775	Rab subfamily motif 3 (RabSF3); other site
983548002776	G4 box; other site
983548002777	G5 box; other site
983548002778	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
983548002779	AMP binding site [chemical binding]; other site
983548002780	metal binding site [ion binding]; metal-binding site
983548002781	active site
983548002782	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
983548002783	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548002784	Coenzyme A binding pocket [chemical binding]; other site
983548002785	Aspartokinases [Amino acid transport and metabolism]; Region: LysC; COG0527
983548002786	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
983548002787	nucleotide binding site [chemical binding]; other site
983548002788	substrate binding site [chemical binding]; other site
983548002789	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
983548002790	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
983548002791	putative acyl-acceptor binding pocket; other site
983548002792	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
983548002793	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
983548002794	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
983548002795	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548002796	phosphorylation site [posttranslational modification]
983548002797	intermolecular recognition site; other site
983548002798	PAS fold; Region: PAS_3; pfam08447
983548002799	PAS domain S-box; Region: sensory_box; TIGR00229
983548002800	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548002801	putative active site [active]
983548002802	heme pocket [chemical binding]; other site
983548002803	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548002804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002805	ATP binding site [chemical binding]; other site
983548002806	Mg2+ binding site [ion binding]; other site
983548002807	G-X-G motif; other site
983548002808	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548002809	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548002810	catalytic residue [active]
983548002811	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548002812	dimerization interface [polypeptide binding]; other site
983548002813	putative DNA binding site [nucleotide binding]; other site
983548002814	putative Zn2+ binding site [ion binding]; other site
983548002815	TM2 domain; Region: TM2; pfam05154
983548002816	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
983548002817	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548002818	active site
983548002819	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
983548002820	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
983548002821	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_14; cd12179
983548002822	putative ligand binding site [chemical binding]; other site
983548002823	putative NAD binding site [chemical binding]; other site
983548002824	catalytic site [active]
983548002825	Cupin; Region: Cupin_1; pfam00190
983548002826	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
983548002827	active site
983548002828	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
983548002829	MgtE intracellular N domain; Region: MgtE_N; smart00924
983548002830	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
983548002831	Divalent cation transporter; Region: MgtE; pfam01769
983548002832	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
983548002833	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
983548002834	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
983548002835	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548002836	binding surface
983548002837	TPR motif; other site
983548002838	seryl-tRNA synthetase; Provisional; Region: PRK05431
983548002839	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
983548002840	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
983548002841	motif 1; other site
983548002842	dimer interface [polypeptide binding]; other site
983548002843	active site
983548002844	motif 2; other site
983548002845	motif 3; other site
983548002846	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
983548002847	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
983548002848	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
983548002849	active site
983548002850	Riboflavin kinase; Region: Flavokinase; pfam01687
983548002851	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
983548002852	putative active site [active]
983548002853	catalytic residue [active]
983548002854	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
983548002855	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
983548002856	5S rRNA interface [nucleotide binding]; other site
983548002857	CTC domain interface [polypeptide binding]; other site
983548002858	L16 interface [polypeptide binding]; other site
983548002859	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
983548002860	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
983548002861	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548002862	active site
983548002863	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
983548002864	MG2 domain; Region: A2M_N; pfam01835
983548002865	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
983548002866	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548002867	ATP-dependent DNA ligase; Validated; Region: PRK09247
983548002868	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
983548002869	active site
983548002870	DNA binding site [nucleotide binding]
983548002871	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
983548002872	DNA binding site [nucleotide binding]
983548002873	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
983548002874	putative active site [active]
983548002875	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
983548002876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
983548002877	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548002878	ATP binding site [chemical binding]; other site
983548002879	putative Mg++ binding site [ion binding]; other site
983548002880	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548002881	nucleotide binding region [chemical binding]; other site
983548002882	ATP-binding site [chemical binding]; other site
983548002883	DEAD/H associated; Region: DEAD_assoc; pfam08494
983548002884	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
983548002885	Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993
983548002886	putative active site [active]
983548002887	Zn binding site [ion binding]; other site
983548002888	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
983548002889	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
983548002890	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
983548002891	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
983548002892	RNA binding site [nucleotide binding]; other site
983548002893	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
983548002894	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
983548002895	active site
983548002896	HIGH motif; other site
983548002897	KMSKS motif; other site
983548002898	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
983548002899	tRNA binding surface [nucleotide binding]; other site
983548002900	anticodon binding site; other site
983548002901	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
983548002902	dimer interface [polypeptide binding]; other site
983548002903	putative tRNA-binding site [nucleotide binding]; other site
983548002904	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
983548002905	dimer interface [polypeptide binding]; other site
983548002906	catalytic triad [active]
983548002907	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
983548002908	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
983548002909	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548002910	non-specific DNA binding site [nucleotide binding]; other site
983548002911	salt bridge; other site
983548002912	sequence-specific DNA binding site [nucleotide binding]; other site
983548002913	Transcriptional regulator [Transcription]; Region: LysR; COG0583
983548002914	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
983548002915	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
983548002916	dimerization interface [polypeptide binding]; other site
983548002917	Domain of unknown function (DUF897); Region: DUF897; cl01312
983548002918	Uncharacterized conserved protein [Function unknown]; Region: COG1284
983548002919	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
983548002920	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
983548002921	Protein of unknown function (Porph_ging); Region: Porph_ging; cl09903
983548002922	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548002923	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
983548002924	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
983548002925	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
983548002926	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548002927	ATP binding site [chemical binding]; other site
983548002928	putative Mg++ binding site [ion binding]; other site
983548002929	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548002930	nucleotide binding region [chemical binding]; other site
983548002931	ATP-binding site [chemical binding]; other site
983548002932	TRCF domain; Region: TRCF; pfam03461
983548002933	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
983548002934	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
983548002935	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548002936	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548002937	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
983548002938	tyrosine decarboxylase; Region: PLN02880
983548002939	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
983548002940	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548002941	catalytic residue [active]
983548002942	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
983548002943	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
983548002944	putative active site [active]
983548002945	putative metal binding site [ion binding]; other site
983548002946	Lycopene cyclase protein; Region: Lycopene_cycl; pfam05834
983548002947	lycopene cyclase; Region: lycopene_cycl; TIGR01789
983548002948	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
983548002949	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548002950	motif II; other site
983548002951	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
983548002952	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
983548002953	putative metal binding site [ion binding]; other site
983548002954	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
983548002955	HSP70 interaction site [polypeptide binding]; other site
983548002956	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
983548002957	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
983548002958	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548002959	Zn2+ binding site [ion binding]; other site
983548002960	Mg2+ binding site [ion binding]; other site
983548002961	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
983548002962	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548002963	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002964	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
983548002965	metal ion-dependent adhesion site (MIDAS); other site
983548002966	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002967	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548002968	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548002969	TPR motif; other site
983548002970	TPR repeat; Region: TPR_11; pfam13414
983548002971	binding surface
983548002972	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
983548002973	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
983548002974	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
983548002975	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
983548002976	substrate binding site [chemical binding]; other site
983548002977	oxyanion hole (OAH) forming residues; other site
983548002978	trimer interface [polypeptide binding]; other site
983548002979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548002980	HAMP domain; Region: HAMP; pfam00672
983548002981	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548002982	dimer interface [polypeptide binding]; other site
983548002983	phosphorylation site [posttranslational modification]
983548002984	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548002985	ATP binding site [chemical binding]; other site
983548002986	Mg2+ binding site [ion binding]; other site
983548002987	G-X-G motif; other site
983548002988	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
983548002989	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
983548002990	VPS10 domain; Region: VPS10; smart00602
983548002991	Asp-box motif; other site
983548002992	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
983548002993	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
983548002994	ferrochelatase; Reviewed; Region: hemH; PRK00035
983548002995	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
983548002996	C-terminal domain interface [polypeptide binding]; other site
983548002997	active site
983548002998	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
983548002999	active site
983548003000	N-terminal domain interface [polypeptide binding]; other site
983548003001	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
983548003002	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
983548003003	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
983548003004	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
983548003005	tRNA; other site
983548003006	putative tRNA binding site [nucleotide binding]; other site
983548003007	putative NADP binding site [chemical binding]; other site
983548003008	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
983548003009	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
983548003010	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
983548003011	domain interfaces; other site
983548003012	active site
983548003013	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
983548003014	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
983548003015	active site
983548003016	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
983548003017	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
983548003018	substrate binding site [chemical binding]; other site
983548003019	active site
983548003020	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
983548003021	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
983548003022	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
983548003023	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
983548003024	DEAD-like helicases superfamily; Region: DEXDc; smart00487
983548003025	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548003026	ATP binding site [chemical binding]; other site
983548003027	putative Mg++ binding site [ion binding]; other site
983548003028	nucleotide binding region [chemical binding]; other site
983548003029	helicase superfamily c-terminal domain; Region: HELICc; smart00490
983548003030	ATP-binding site [chemical binding]; other site
983548003031	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
983548003032	dimer interface [polypeptide binding]; other site
983548003033	allosteric magnesium binding site [ion binding]; other site
983548003034	active site
983548003035	aspartate-rich active site metal binding site; other site
983548003036	Schiff base residues; other site
983548003037	Domain of unknown function (DUF3291); Region: DUF3291; pfam11695
983548003038	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
983548003039	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
983548003040	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548003041	motif II; other site
983548003042	Domain of unknown function DUF21; Region: DUF21; pfam01595
983548003043	FOG: CBS domain [General function prediction only]; Region: COG0517
983548003044	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
983548003045	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548003046	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003047	TPR motif; other site
983548003048	binding surface
983548003049	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548003050	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548003051	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548003052	dimer interface [polypeptide binding]; other site
983548003053	phosphorylation site [posttranslational modification]
983548003054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548003055	ATP binding site [chemical binding]; other site
983548003056	Mg2+ binding site [ion binding]; other site
983548003057	G-X-G motif; other site
983548003058	Response regulator receiver domain; Region: Response_reg; pfam00072
983548003059	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548003060	active site
983548003061	phosphorylation site [posttranslational modification]
983548003062	intermolecular recognition site; other site
983548003063	dimerization interface [polypeptide binding]; other site
983548003064	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
983548003065	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
983548003066	DNA binding site [nucleotide binding]
983548003067	active site
983548003068	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
983548003069	Beta-lactamase; Region: Beta-lactamase; pfam00144
983548003070	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
983548003071	active site
983548003072	catalytic site [active]
983548003073	substrate binding site [chemical binding]; other site
983548003074	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
983548003075	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
983548003076	Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128
983548003077	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
983548003078	Zn binding site [ion binding]; other site
983548003079	Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cd06263
983548003080	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
983548003081	Interdomain contacts; other site
983548003082	Cytokine receptor motif; other site
983548003083	Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members...; Region: MAM; cl02479
983548003084	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548003085	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
983548003086	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
983548003087	Walker A/P-loop; other site
983548003088	ATP binding site [chemical binding]; other site
983548003089	Q-loop/lid; other site
983548003090	ABC transporter signature motif; other site
983548003091	Walker B; other site
983548003092	D-loop; other site
983548003093	H-loop/switch region; other site
983548003094	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
983548003095	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
983548003096	Walker A/P-loop; other site
983548003097	ATP binding site [chemical binding]; other site
983548003098	Q-loop/lid; other site
983548003099	ABC transporter signature motif; other site
983548003100	Walker B; other site
983548003101	D-loop; other site
983548003102	H-loop/switch region; other site
983548003103	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
983548003104	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
983548003105	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
983548003106	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
983548003107	Transglycosylase; Region: Transgly; pfam00912
983548003108	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
983548003109	GldH lipoprotein; Region: GldH_lipo; pfam14109
983548003110	PSP1 C-terminal conserved region; Region: PSP1; cl00770
983548003111	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
983548003112	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
983548003113	active site residue [active]
983548003114	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
983548003115	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
983548003116	hexamer interface [polypeptide binding]; other site
983548003117	Walker A motif; other site
983548003118	ATP binding site [chemical binding]; other site
983548003119	Walker B motif; other site
983548003120	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548003121	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548003122	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548003123	DNA binding residues [nucleotide binding]
983548003124	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548003125	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
983548003126	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
983548003127	putative acyl-acceptor binding pocket; other site
983548003128	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
983548003129	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
983548003130	active site
983548003131	HIGH motif; other site
983548003132	dimer interface [polypeptide binding]; other site
983548003133	KMSKS motif; other site
983548003134	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
983548003135	active site
983548003136	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
983548003137	putative active site [active]
983548003138	putative metal binding site [ion binding]; other site
983548003139	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
983548003140	DHH family; Region: DHH; pfam01368
983548003141	DHHA1 domain; Region: DHHA1; pfam02272
983548003142	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
983548003143	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
983548003144	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548003145	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
983548003146	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003147	active site
983548003148	HIGH motif; other site
983548003149	nucleotide binding site [chemical binding]; other site
983548003150	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003151	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003152	active site
983548003153	KMSKS motif; other site
983548003154	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
983548003155	tRNA binding surface [nucleotide binding]; other site
983548003156	anticodon binding site; other site
983548003157	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
983548003158	lipoprotein signal peptidase; Provisional; Region: PRK14788
983548003159	lipoprotein signal peptidase; Provisional; Region: PRK14787
983548003160	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548003161	Response regulator receiver domain; Region: Response_reg; pfam00072
983548003162	active site
983548003163	phosphorylation site [posttranslational modification]
983548003164	intermolecular recognition site; other site
983548003165	dimerization interface [polypeptide binding]; other site
983548003166	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548003167	putative active site [active]
983548003168	heme pocket [chemical binding]; other site
983548003169	PAS domain; Region: PAS_9; pfam13426
983548003170	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548003171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548003172	ATP binding site [chemical binding]; other site
983548003173	Mg2+ binding site [ion binding]; other site
983548003174	G-X-G motif; other site
983548003175	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
983548003176	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
983548003177	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
983548003178	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
983548003179	putative active site [active]
983548003180	Zn binding site [ion binding]; other site
983548003181	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
983548003182	ATP-grasp domain; Region: ATP-grasp_4; cl17255
983548003183	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
983548003184	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
983548003185	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
983548003186	GIY-YIG motif/motif A; other site
983548003187	active site
983548003188	catalytic site [active]
983548003189	putative DNA binding site [nucleotide binding]; other site
983548003190	metal binding site [ion binding]; metal-binding site
983548003191	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
983548003192	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
983548003193	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
983548003194	active site
983548003195	nucleophile elbow; other site
983548003196	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548003197	Bacterial SH3 domain; Region: SH3_3; cl17532
983548003198	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
983548003199	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
983548003200	domain interfaces; other site
983548003201	active site
983548003202	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548003203	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548003204	dimer interface [polypeptide binding]; other site
983548003205	phosphorylation site [posttranslational modification]
983548003206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548003207	ATP binding site [chemical binding]; other site
983548003208	Mg2+ binding site [ion binding]; other site
983548003209	G-X-G motif; other site
983548003210	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
983548003211	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
983548003212	dimerization interface [polypeptide binding]; other site
983548003213	active site
983548003214	metal binding site [ion binding]; metal-binding site
983548003215	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
983548003216	dsRNA binding site [nucleotide binding]; other site
983548003217	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
983548003218	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
983548003219	dimer interface [polypeptide binding]; other site
983548003220	active site
983548003221	acyl carrier protein; Provisional; Region: acpP; PRK00982
983548003222	Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299
983548003223	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
983548003224	active site
983548003225	substrate binding site [chemical binding]; other site
983548003226	cosubstrate binding site; other site
983548003227	catalytic site [active]
983548003228	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
983548003229	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
983548003230	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
983548003231	active site
983548003232	RNA/DNA hybrid binding site [nucleotide binding]; other site
983548003233	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
983548003234	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
983548003235	substrate binding site [chemical binding]; other site
983548003236	ATP binding site [chemical binding]; other site
983548003237	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
983548003238	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
983548003239	active site
983548003240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548003241	active site
983548003242	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
983548003243	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
983548003244	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
983548003245	putative recombination protein RecB; Provisional; Region: PRK13909
983548003246	Family description; Region: UvrD_C_2; pfam13538
983548003247	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
983548003248	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
983548003249	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
983548003250	substrate-cofactor binding pocket; other site
983548003251	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548003252	catalytic residue [active]
983548003253	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
983548003254	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548003255	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548003256	ligand binding site [chemical binding]; other site
983548003257	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
983548003258	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
983548003259	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
983548003260	active site
983548003261	DNA binding site [nucleotide binding]
983548003262	Int/Topo IB signature motif; other site
983548003263	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
983548003264	CHC2 zinc finger; Region: zf-CHC2; cl17510
983548003265	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
983548003266	active site
983548003267	metal binding site [ion binding]; metal-binding site
983548003268	interdomain interaction site; other site
983548003269	Virulence-associated protein E; Region: VirE; pfam05272
983548003270	Helix-turn-helix domain; Region: HTH_17; pfam12728
983548003271	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
983548003272	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
983548003273	Soluble P-type ATPase [General function prediction only]; Region: COG4087
983548003274	MerT mercuric transport protein; Region: MerT; cl03578
983548003275	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
983548003276	metal-binding site [ion binding]
983548003277	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
983548003278	metal binding site 2 [ion binding]; metal-binding site
983548003279	putative DNA binding helix; other site
983548003280	metal binding site 1 [ion binding]; metal-binding site
983548003281	dimer interface [polypeptide binding]; other site
983548003282	structural Zn2+ binding site [ion binding]; other site
983548003283	Cation efflux family; Region: Cation_efflux; pfam01545
983548003284	HlyD family secretion protein; Region: HlyD_2; pfam12700
983548003285	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548003286	putative membrane fusion protein; Region: TIGR02828
983548003287	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
983548003288	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
983548003289	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
983548003290	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
983548003291	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548003292	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
983548003293	Domain of unknown function (DUF305); Region: DUF305; cl17794
983548003294	PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706
983548003295	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
983548003296	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
983548003297	metal-binding site [ion binding]
983548003298	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
983548003299	metal-binding site [ion binding]
983548003300	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
983548003301	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
983548003302	Soluble P-type ATPase [General function prediction only]; Region: COG4087
983548003303	Ion channel; Region: Ion_trans_2; pfam07885
983548003304	Haem-binding domain; Region: Haem_bd; pfam14376
983548003305	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
983548003306	multicopper oxidase; Provisional; Region: PRK10965
983548003307	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
983548003308	Multicopper oxidase; Region: Cu-oxidase; pfam00394
983548003309	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
983548003310	Protein of unknown function, DUF481; Region: DUF481; cl01213
983548003311	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
983548003312	Outer membrane efflux protein; Region: OEP; pfam02321
983548003313	Outer membrane efflux protein; Region: OEP; pfam02321
983548003314	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
983548003315	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
983548003316	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548003317	Ligand Binding Site [chemical binding]; other site
983548003318	putative acetyltransferase; Provisional; Region: PRK03624
983548003319	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548003320	Coenzyme A binding pocket [chemical binding]; other site
983548003321	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
983548003322	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
983548003323	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
983548003324	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
983548003325	TrkA-N domain; Region: TrkA_N; pfam02254
983548003326	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548003327	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
983548003328	Peptidase S8 family domain in Subtilisin_Novo-like proteins; Region: Peptidases_S8_Subtilisin_Novo-like; cd07483
983548003329	active site
983548003330	catalytic triad [active]
983548003331	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
983548003332	Zn binding site [ion binding]; other site
983548003333	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
983548003334	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
983548003335	active site
983548003336	DNA binding site [nucleotide binding]
983548003337	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
983548003338	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
983548003339	Catalytic site [active]
983548003340	ribonuclease P; Reviewed; Region: rnpA; PRK01903
983548003341	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
983548003342	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
983548003343	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
983548003344	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
983548003345	protein binding site [polypeptide binding]; other site
983548003346	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
983548003347	Catalytic dyad [active]
983548003348	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548003349	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548003350	ligand binding site [chemical binding]; other site
983548003351	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548003352	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548003353	ligand binding site [chemical binding]; other site
983548003354	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
983548003355	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
983548003356	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
983548003357	ribonuclease R; Region: RNase_R; TIGR02063
983548003358	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
983548003359	RNB domain; Region: RNB; pfam00773
983548003360	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
983548003361	RNA binding site [nucleotide binding]; other site
983548003362	Predicted amidohydrolase [General function prediction only]; Region: COG0388
983548003363	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
983548003364	putative active site [active]
983548003365	catalytic triad [active]
983548003366	putative dimer interface [polypeptide binding]; other site
983548003367	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
983548003368	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
983548003369	Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539
983548003370	active site
983548003371	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
983548003372	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
983548003373	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003374	active site
983548003375	HIGH motif; other site
983548003376	nucleotide binding site [chemical binding]; other site
983548003377	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
983548003378	KMSKS motif; other site
983548003379	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
983548003380	flap endonuclease-like protein; Provisional; Region: PRK09482
983548003381	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
983548003382	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
983548003383	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548003384	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
983548003385	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
983548003386	active site
983548003387	HIGH motif; other site
983548003388	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
983548003389	active site
983548003390	KMSKS motif; other site
983548003391	Frag1/DRAM/Sfk1 family; Region: Frag1; pfam10277
983548003392	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
983548003393	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
983548003394	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
983548003395	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
983548003396	Methyltransferase domain; Region: Methyltransf_23; pfam13489
983548003397	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548003398	S-adenosylmethionine binding site [chemical binding]; other site
983548003399	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
983548003400	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
983548003401	Phosphoglycerate kinase; Region: PGK; pfam00162
983548003402	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
983548003403	substrate binding site [chemical binding]; other site
983548003404	hinge regions; other site
983548003405	ADP binding site [chemical binding]; other site
983548003406	catalytic site [active]
983548003407	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
983548003408	N-acetyl-D-glucosamine binding site [chemical binding]; other site
983548003409	catalytic residue [active]
983548003410	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548003411	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548003412	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
983548003413	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
983548003414	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548003415	GH3 auxin-responsive promoter; Region: GH3; pfam03321
983548003416	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
983548003417	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
983548003418	NADP-binding site; other site
983548003419	homotetramer interface [polypeptide binding]; other site
983548003420	substrate binding site [chemical binding]; other site
983548003421	homodimer interface [polypeptide binding]; other site
983548003422	active site
983548003423	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
983548003424	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
983548003425	NADP binding site [chemical binding]; other site
983548003426	active site
983548003427	putative substrate binding site [chemical binding]; other site
983548003428	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
983548003429	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
983548003430	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
983548003431	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548003432	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548003433	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
983548003434	O-Antigen ligase; Region: Wzy_C; pfam04932
983548003435	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548003436	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
983548003437	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
983548003438	putative glycosyl transferase; Provisional; Region: PRK10307
983548003439	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
983548003440	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
983548003441	NAD binding site [chemical binding]; other site
983548003442	putative substrate binding site 2 [chemical binding]; other site
983548003443	putative substrate binding site 1 [chemical binding]; other site
983548003444	active site
983548003445	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
983548003446	Bacterial sugar transferase; Region: Bac_transf; pfam02397
983548003447	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548003448	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
983548003449	active site
983548003450	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
983548003451	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
983548003452	active site
983548003453	AMP binding site [chemical binding]; other site
983548003454	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
983548003455	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
983548003456	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
983548003457	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
983548003458	Protein of unknown function (DUF4254); Region: DUF4254; pfam14063
983548003459	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
983548003460	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
983548003461	putative active site [active]
983548003462	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
983548003463	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
983548003464	FMN binding site [chemical binding]; other site
983548003465	substrate binding site [chemical binding]; other site
983548003466	putative catalytic residue [active]
983548003467	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548003468	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
983548003469	Walker A/P-loop; other site
983548003470	ATP binding site [chemical binding]; other site
983548003471	Q-loop/lid; other site
983548003472	ABC transporter signature motif; other site
983548003473	Walker B; other site
983548003474	D-loop; other site
983548003475	H-loop/switch region; other site
983548003476	na(+)/h(+) antiporter; Region: c_cpa1; TIGR00844
983548003477	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
983548003478	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
983548003479	FAD binding pocket [chemical binding]; other site
983548003480	FAD binding motif [chemical binding]; other site
983548003481	phosphate binding motif [ion binding]; other site
983548003482	beta-alpha-beta structure motif; other site
983548003483	NAD(p) ribose binding residues [chemical binding]; other site
983548003484	NAD binding pocket [chemical binding]; other site
983548003485	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
983548003486	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
983548003487	catalytic loop [active]
983548003488	iron binding site [ion binding]; other site
983548003489	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
983548003490	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
983548003491	Walker A/P-loop; other site
983548003492	ATP binding site [chemical binding]; other site
983548003493	Q-loop/lid; other site
983548003494	ABC transporter signature motif; other site
983548003495	Walker B; other site
983548003496	D-loop; other site
983548003497	H-loop/switch region; other site
983548003498	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
983548003499	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
983548003500	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
983548003501	ATP synthase A chain; Region: ATP-synt_A; cl00413
983548003502	F0F1 ATP synthase subunit B; Provisional; Region: PRK14471
983548003503	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
983548003504	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
983548003505	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
983548003506	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
983548003507	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
983548003508	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
983548003509	beta subunit interaction interface [polypeptide binding]; other site
983548003510	Walker A motif; other site
983548003511	ATP binding site [chemical binding]; other site
983548003512	Walker B motif; other site
983548003513	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
983548003514	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
983548003515	core domain interface [polypeptide binding]; other site
983548003516	delta subunit interface [polypeptide binding]; other site
983548003517	epsilon subunit interface [polypeptide binding]; other site
983548003518	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
983548003519	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
983548003520	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
983548003521	trimer interface [polypeptide binding]; other site
983548003522	active site
983548003523	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
983548003524	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
983548003525	active site
983548003526	Substrate binding site; other site
983548003527	Mg++ binding site; other site
983548003528	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
983548003529	TPR repeat; Region: TPR_11; pfam13414
983548003530	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003531	TPR motif; other site
983548003532	Tetratricopeptide repeat; Region: TPR_16; pfam13432
983548003533	binding surface
983548003534	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548003535	binding surface
983548003536	TPR motif; other site
983548003537	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003538	binding surface
983548003539	TPR motif; other site
983548003540	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
983548003541	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
983548003542	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548003543	CsbD-like; Region: CsbD; pfam05532
983548003544	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
983548003545	Sporulation related domain; Region: SPOR; pfam05036
983548003546	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
983548003547	DNA protecting protein DprA; Region: dprA; TIGR00732
983548003548	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
983548003549	BON domain; Region: BON; pfam04972
983548003550	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548003551	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
983548003552	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
983548003553	active site
983548003554	(T/H)XGH motif; other site
983548003555	HopJ type III effector protein; Region: HopJ; pfam08888
983548003556	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
983548003557	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
983548003558	catalytic site [active]
983548003559	G-X2-G-X-G-K; other site
983548003560	hypothetical protein; Provisional; Region: PRK11820
983548003561	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
983548003562	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
983548003563	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
983548003564	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
983548003565	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
983548003566	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
983548003567	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
983548003568	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
983548003569	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
983548003570	Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825
983548003571	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548003572	putative substrate translocation pore; other site
983548003573	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
983548003574	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
983548003575	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548003576	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
983548003577	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
983548003578	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
983548003579	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
983548003580	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
983548003581	Bacitracin resistance protein BacA; Region: BacA; pfam02673
983548003582	Polysaccharide lyase; Region: Polysacc_lyase; pfam14099
983548003583	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
983548003584	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
983548003585	RNA binding site [nucleotide binding]; other site
983548003586	active site
983548003587	Thioredoxin (TRX) superfamily; a large, diverse group of proteins containing a TRX-fold. Many members contain a classic TRX domain with a redox active CXXC motif. They function as protein disulfide oxidoreductases (PDOs), altering the redox state of...; Region: TRX_superfamily; cd01659
983548003588	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
983548003589	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
983548003590	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
983548003591	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
983548003592	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
983548003593	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
983548003594	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
983548003595	dimer interface [polypeptide binding]; other site
983548003596	putative tRNA-binding site [nucleotide binding]; other site
983548003597	peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562
983548003598	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
983548003599	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548003600	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548003601	ligand binding site [chemical binding]; other site
983548003602	aldehyde dehydrogenase family 7 member; Region: PLN02315
983548003603	NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130
983548003604	tetrameric interface [polypeptide binding]; other site
983548003605	NAD binding site [chemical binding]; other site
983548003606	catalytic residues [active]
983548003607	3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264
983548003608	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
983548003609	L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701
983548003610	catalytic nucleophile [active]
983548003611	Domain of unknown function (DUF329); Region: DUF329; cl01144
983548003612	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
983548003613	FOG: CBS domain [General function prediction only]; Region: COG0517
983548003614	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
983548003615	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
983548003616	Peptidase family M28; Region: Peptidase_M28; pfam04389
983548003617	metal binding site [ion binding]; metal-binding site
983548003618	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
983548003619	NADH(P)-binding; Region: NAD_binding_10; pfam13460
983548003620	putative NAD(P) binding site [chemical binding]; other site
983548003621	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
983548003622	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
983548003623	active site
983548003624	Zn binding site [ion binding]; other site
983548003625	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
983548003626	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
983548003627	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548003628	SnoaL-like domain; Region: SnoaL_3; pfam13474
983548003629	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
983548003630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548003631	NAD(P) binding site [chemical binding]; other site
983548003632	active site
983548003633	Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013
983548003634	hypothetical protein; Provisional; Region: PRK09256
983548003635	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
983548003636	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
983548003637	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
983548003638	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
983548003639	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
983548003640	active site
983548003641	SnoaL-like domain; Region: SnoaL_2; pfam12680
983548003642	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
983548003643	EamA-like transporter family; Region: EamA; pfam00892
983548003644	EamA-like transporter family; Region: EamA; pfam00892
983548003645	Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977
983548003646	ArsC family; Region: ArsC; pfam03960
983548003647	catalytic residue [active]
983548003648	DinB superfamily; Region: DinB_2; pfam12867
983548003649	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
983548003650	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
983548003651	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
983548003652	homodimer interface [polypeptide binding]; other site
983548003653	substrate-cofactor binding pocket; other site
983548003654	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548003655	catalytic residue [active]
983548003656	glutamate dehydrogenase; Provisional; Region: PRK09414
983548003657	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
983548003658	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
983548003659	NAD(P) binding site [chemical binding]; other site
983548003660	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548003661	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
983548003662	Recombination protein O N terminal; Region: RecO_N; pfam11967
983548003663	Recombination protein O C terminal; Region: RecO_C; pfam02565
983548003664	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548003665	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
983548003666	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
983548003667	N-terminal plug; other site
983548003668	ligand-binding site [chemical binding]; other site
983548003669	Predicted methyltransferases [General function prediction only]; Region: COG0313
983548003670	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
983548003671	putative SAM binding site [chemical binding]; other site
983548003672	putative homodimer interface [polypeptide binding]; other site
983548003673	DoxX-like family; Region: DoxX_2; pfam13564
983548003674	thymidine kinase; Provisional; Region: PRK04296
983548003675	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
983548003676	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
983548003677	active site
983548003678	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
983548003679	dimer interface [polypeptide binding]; other site
983548003680	substrate binding site [chemical binding]; other site
983548003681	catalytic residues [active]
983548003682	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
983548003683	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
983548003684	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
983548003685	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
983548003686	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
983548003687	Chloramphenicol acetyltransferase; Region: CAT; cl02008
983548003688	Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505
983548003689	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548003690	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240
983548003691	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
983548003692	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
983548003693	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
983548003694	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
983548003695	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
983548003696	dimer interface [polypeptide binding]; other site
983548003697	motif 1; other site
983548003698	active site
983548003699	motif 2; other site
983548003700	motif 3; other site
983548003701	Colicin V production protein; Region: Colicin_V; pfam02674
983548003702	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
983548003703	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
983548003704	Sulfate transporter family; Region: Sulfate_transp; pfam00916
983548003705	Sulfate transporter family; Region: Sulfate_transp; pfam00916
983548003706	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
983548003707	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
983548003708	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
983548003709	active site clefts [active]
983548003710	zinc binding site [ion binding]; other site
983548003711	dimer interface [polypeptide binding]; other site
983548003712	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
983548003713	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
983548003714	Sulfate transporter family; Region: Sulfate_transp; pfam00916
983548003715	TPR repeat; Region: TPR_11; pfam13414
983548003716	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003717	binding surface
983548003718	TPR motif; other site
983548003719	Bacterial SH3 domain; Region: SH3_3; cl17532
983548003720	Oxygen tolerance; Region: BatD; pfam13584
983548003721	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003722	TPR motif; other site
983548003723	TPR repeat; Region: TPR_11; pfam13414
983548003724	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
983548003725	metal ion-dependent adhesion site (MIDAS); other site
983548003726	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
983548003727	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
983548003728	metal ion-dependent adhesion site (MIDAS); other site
983548003729	Protein of unknown function (DUF805); Region: DUF805; pfam05656
983548003730	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
983548003731	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
983548003732	metal ion-dependent adhesion site (MIDAS); other site
983548003733	MoxR-like ATPases [General function prediction only]; Region: COG0714
983548003734	ATPase family associated with various cellular activities (AAA); Region: AAA_3; pfam07726
983548003735	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
983548003736	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
983548003737	active site
983548003738	catalytic tetrad [active]
983548003739	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548003740	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
983548003741	NAD(P) binding site [chemical binding]; other site
983548003742	active site
983548003743	Divergent AAA domain; Region: AAA_4; pfam04326
983548003744	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
983548003745	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
983548003746	active site
983548003747	metal binding site [ion binding]; metal-binding site
983548003748	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
983548003749	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548003750	phosphorylation site [posttranslational modification]
983548003751	dimer interface [polypeptide binding]; other site
983548003752	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548003753	ATP binding site [chemical binding]; other site
983548003754	Mg2+ binding site [ion binding]; other site
983548003755	G-X-G motif; other site
983548003756	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
983548003757	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
983548003758	dimer interface [polypeptide binding]; other site
983548003759	ADP-ribose binding site [chemical binding]; other site
983548003760	active site
983548003761	nudix motif; other site
983548003762	metal binding site [ion binding]; metal-binding site
983548003763	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
983548003764	nucleotide binding site/active site [active]
983548003765	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
983548003766	four helix bundle protein; Region: TIGR02436
983548003767	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
983548003768	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
983548003769	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
983548003770	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548003771	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548003772	2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745
983548003773	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
983548003774	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
983548003775	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
983548003776	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003777	active site
983548003778	HIGH motif; other site
983548003779	nucleotide binding site [chemical binding]; other site
983548003780	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003781	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
983548003782	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003783	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003784	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548003785	active site
983548003786	KMSKS motif; other site
983548003787	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
983548003788	tRNA binding surface [nucleotide binding]; other site
983548003789	Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264
983548003790	Uncharacterized conserved protein [Function unknown]; Region: COG4095
983548003791	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
983548003792	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
983548003793	hexamer interface [polypeptide binding]; other site
983548003794	ligand binding site [chemical binding]; other site
983548003795	putative active site [active]
983548003796	NAD(P) binding site [chemical binding]; other site
983548003797	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
983548003798	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548003799	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548003800	catalytic residues [active]
983548003801	Clp protease; Region: CLP_protease; pfam00574
983548003802	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
983548003803	oligomer interface [polypeptide binding]; other site
983548003804	active site residues [active]
983548003805	Protein of unknown function DUF58; Region: DUF58; pfam01882
983548003806	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
983548003807	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
983548003808	metal binding site [ion binding]; metal-binding site
983548003809	dimer interface [polypeptide binding]; other site
983548003810	methionine sulfoxide reductase A; Provisional; Region: PRK14054
983548003811	Protein of unknown function (DUF2452); Region: DUF2452; pfam10504
983548003812	Protein of unknown function (DUF2805); Region: DUF2805; pfam10985
983548003813	DNA photolyase; Region: DNA_photolyase; pfam00875
983548003814	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
983548003815	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
983548003816	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
983548003817	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
983548003818	DNA photolyase; Region: DNA_photolyase; pfam00875
983548003819	Domain of unknown function (DUF4301); Region: DUF4301; pfam14134
983548003820	AAA domain; Region: AAA_28; pfam13521
983548003821	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
983548003822	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
983548003823	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548003824	geranylgeranylglyceryl phosphate synthase-like protein; Reviewed; Region: PRK04169
983548003825	PcrB family; Region: PcrB; pfam01884
983548003826	phosphate binding site [ion binding]; other site
983548003827	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
983548003828	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
983548003829	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
983548003830	homotetramer interface [polypeptide binding]; other site
983548003831	ligand binding site [chemical binding]; other site
983548003832	catalytic site [active]
983548003833	NAD binding site [chemical binding]; other site
983548003834	TM2 domain; Region: TM2; pfam05154
983548003835	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
983548003836	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548003837	putative DNA binding site [nucleotide binding]; other site
983548003838	putative Zn2+ binding site [ion binding]; other site
983548003839	AsnC family; Region: AsnC_trans_reg; pfam01037
983548003840	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
983548003841	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
983548003842	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
983548003843	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
983548003844	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
983548003845	active site
983548003846	substrate-binding site [chemical binding]; other site
983548003847	metal-binding site [ion binding]
983548003848	ATP binding site [chemical binding]; other site
983548003849	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
983548003850	EamA-like transporter family; Region: EamA; pfam00892
983548003851	EamA-like transporter family; Region: EamA; pfam00892
983548003852	gliding motility-associated lipoprotein GldD; Region: GldD_lipo; TIGR03512
983548003853	gliding motility-associated protein GldE; Region: GldE; TIGR03520
983548003854	Domain of unknown function DUF21; Region: DUF21; pfam01595
983548003855	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
983548003856	Transporter associated domain; Region: CorC_HlyC; smart01091
983548003857	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
983548003858	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
983548003859	dimer interface [polypeptide binding]; other site
983548003860	ssDNA binding site [nucleotide binding]; other site
983548003861	tetramer (dimer of dimers) interface [polypeptide binding]; other site
983548003862	Helix-turn-helix domain; Region: HTH_18; pfam12833
983548003863	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
983548003864	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
983548003865	minor groove reading motif; other site
983548003866	helix-hairpin-helix signature motif; other site
983548003867	substrate binding pocket [chemical binding]; other site
983548003868	active site
983548003869	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
983548003870	DNA binding and oxoG recognition site [nucleotide binding]
983548003871	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
983548003872	IHF - DNA interface [nucleotide binding]; other site
983548003873	IHF dimer interface [polypeptide binding]; other site
983548003874	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
983548003875	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
983548003876	homodimer interface [polypeptide binding]; other site
983548003877	oligonucleotide binding site [chemical binding]; other site
983548003878	RecX family; Region: RecX; pfam02631
983548003879	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548003880	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548003881	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548003882	GLPGLI family protein; Region: GLPGLI; TIGR01200
983548003883	PAS domain; Region: PAS_9; pfam13426
983548003884	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548003885	putative active site [active]
983548003886	heme pocket [chemical binding]; other site
983548003887	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
983548003888	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
983548003889	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
983548003890	FeoA domain; Region: FeoA; pfam04023
983548003891	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
983548003892	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
983548003893	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
983548003894	intersubunit interface [polypeptide binding]; other site
983548003895	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
983548003896	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
983548003897	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
983548003898	four helix bundle protein; Region: TIGR02436
983548003899	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
983548003900	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
983548003901	ABC-ATPase subunit  interface; other site
983548003902	dimer interface [polypeptide binding]; other site
983548003903	putative PBP binding regions; other site
983548003904	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
983548003905	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
983548003906	ABC-ATPase subunit  interface; other site
983548003907	dimer interface [polypeptide binding]; other site
983548003908	putative PBP binding regions; other site
983548003909	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
983548003910	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
983548003911	G1 box; other site
983548003912	GTP/Mg2+ binding site [chemical binding]; other site
983548003913	Switch I region; other site
983548003914	G2 box; other site
983548003915	G3 box; other site
983548003916	Switch II region; other site
983548003917	G4 box; other site
983548003918	G5 box; other site
983548003919	Nucleoside recognition; Region: Gate; pfam07670
983548003920	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
983548003921	Nucleoside recognition; Region: Gate; pfam07670
983548003922	FeoA domain; Region: FeoA; pfam04023
983548003923	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
983548003924	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
983548003925	Cu(I) binding site [ion binding]; other site
983548003926	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
983548003927	RIP metalloprotease RseP; Region: TIGR00054
983548003928	active site
983548003929	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
983548003930	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
983548003931	protein binding site [polypeptide binding]; other site
983548003932	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
983548003933	putative substrate binding region [chemical binding]; other site
983548003934	Calx-beta domain; Region: Calx-beta; cl02522
983548003935	Calx-beta domain; Region: Calx-beta; cl02522
983548003936	Calx-beta domain; Region: Calx-beta; cl02522
983548003937	Calx-beta domain; Region: Calx-beta; cl02522
983548003938	Calx-beta domain; Region: Calx-beta; cl02522
983548003939	Calx-beta domain; Region: Calx-beta; cl02522
983548003940	Calx-beta domain; Region: Calx-beta; cl02522
983548003941	Calx-beta domain; Region: Calx-beta; cl02522
983548003942	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548003943	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548003944	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
983548003945	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548003946	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548003947	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548003948	ligand binding site [chemical binding]; other site
983548003949	Penicillinase repressor; Region: Pencillinase_R; pfam03965
983548003950	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
983548003951	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
983548003952	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548003953	binding surface
983548003954	TPR motif; other site
983548003955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003956	binding surface
983548003957	TPR motif; other site
983548003958	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548003959	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548003960	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548003961	binding surface
983548003962	TPR motif; other site
983548003963	TPR repeat; Region: TPR_11; pfam13414
983548003964	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
983548003965	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_e; cd04192
983548003966	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
983548003967	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
983548003968	active site
983548003969	putative DNA-binding cleft [nucleotide binding]; other site
983548003970	dimer interface [polypeptide binding]; other site
983548003971	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
983548003972	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548003973	FeS/SAM binding site; other site
983548003974	HemN C-terminal domain; Region: HemN_C; pfam06969
983548003975	Putative cyclase; Region: Cyclase; pfam04199
983548003976	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
983548003977	MG2 domain; Region: A2M_N; pfam01835
983548003978	Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703
983548003979	Alpha-2-macroglobulin family; Region: A2M; pfam00207
983548003980	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
983548003981	surface patch; other site
983548003982	thioester region; other site
983548003983	specificity defining residues; other site
983548003984	penicillin-binding protein 1C; Region: PBP_1c; TIGR02073
983548003985	Transglycosylase; Region: Transgly; pfam00912
983548003986	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
983548003987	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
983548003988	YCII-related domain; Region: YCII; cl00999
983548003989	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
983548003990	putative active site [active]
983548003991	putative metal binding residues [ion binding]; other site
983548003992	signature motif; other site
983548003993	putative dimer interface [polypeptide binding]; other site
983548003994	putative phosphate binding site [ion binding]; other site
983548003995	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548003996	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
983548003997	active site
983548003998	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548003999	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
983548004000	active site
983548004001	metal binding site [ion binding]; metal-binding site
983548004002	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
983548004003	NADH(P)-binding; Region: NAD_binding_10; pfam13460
983548004004	NAD binding site [chemical binding]; other site
983548004005	active site
983548004006	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
983548004007	active site
983548004008	DNA polymerase IV; Validated; Region: PRK02406
983548004009	DNA binding site [nucleotide binding]
983548004010	SnoaL-like domain; Region: SnoaL_3; pfam13474
983548004011	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
983548004012	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
983548004013	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548004014	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
983548004015	Penicillinase repressor; Region: Pencillinase_R; pfam03965
983548004016	hypothetical protein; Provisional; Region: PRK08201
983548004017	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
983548004018	metal binding site [ion binding]; metal-binding site
983548004019	putative dimer interface [polypeptide binding]; other site
983548004020	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
983548004021	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
983548004022	putative substrate binding site [chemical binding]; other site
983548004023	putative ATP binding site [chemical binding]; other site
983548004024	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
983548004025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548004026	putative substrate translocation pore; other site
983548004027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548004028	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
983548004029	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
983548004030	substrate binding [chemical binding]; other site
983548004031	active site
983548004032	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
983548004033	Transcriptional regulators [Transcription]; Region: PurR; COG1609
983548004034	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
983548004035	DNA binding site [nucleotide binding]
983548004036	domain linker motif; other site
983548004037	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
983548004038	dimerization interface [polypeptide binding]; other site
983548004039	ligand binding site [chemical binding]; other site
983548004040	beta-phosphoglucomutase; Region: bPGM; TIGR01990
983548004041	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548004042	maltose phosphorylase; Provisional; Region: PRK13807
983548004043	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
983548004044	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
983548004045	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
983548004046	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
983548004047	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
983548004048	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
983548004049	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
983548004050	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
983548004051	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
983548004052	active site
983548004053	Family description; Region: VCBS; pfam13517
983548004054	Family description; Region: VCBS; pfam13517
983548004055	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
983548004056	Family description; Region: VCBS; pfam13517
983548004057	Family description; Region: VCBS; pfam13517
983548004058	Family description; Region: VCBS; pfam13517
983548004059	Family description; Region: VCBS; pfam13517
983548004060	Family description; Region: VCBS; pfam13517
983548004061	Family description; Region: VCBS; pfam13517
983548004062	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
983548004063	Family description; Region: VCBS; pfam13517
983548004064	Family description; Region: VCBS; pfam13517
983548004065	Family description; Region: VCBS; pfam13517
983548004066	Family description; Region: VCBS; pfam13517
983548004067	Family description; Region: VCBS; pfam13517
983548004068	Family description; Region: VCBS; pfam13517
983548004069	Family description; Region: VCBS; pfam13517
983548004070	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
983548004071	Family description; Region: VCBS; pfam13517
983548004072	Family description; Region: VCBS; pfam13517
983548004073	Family description; Region: VCBS; pfam13517
983548004074	Family description; Region: VCBS; pfam13517
983548004075	starch binding outer membrane protein SusD; Region: SusD; cl17845
983548004076	SusD family; Region: SusD; pfam07980
983548004077	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548004078	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548004079	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
983548004080	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548004081	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
983548004082	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
983548004083	active site
983548004084	catalytic site [active]
983548004085	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
983548004086	flavoprotein, HI0933 family; Region: TIGR00275
983548004087	TspO/MBR family; Region: TspO_MBR; pfam03073
983548004088	diphosphomevalonate decarboxylase; Region: PLN02407
983548004089	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
983548004090	mevalonate kinase; Region: mevalon_kin; TIGR00549
983548004091	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
983548004092	UbiA prenyltransferase family; Region: UbiA; pfam01040
983548004093	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
983548004094	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
983548004095	DNA-binding site [nucleotide binding]; DNA binding site
983548004096	RNA-binding motif; other site
983548004097	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
983548004098	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
983548004099	dimer interface [polypeptide binding]; other site
983548004100	anticodon binding site; other site
983548004101	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
983548004102	homodimer interface [polypeptide binding]; other site
983548004103	motif 1; other site
983548004104	active site
983548004105	motif 2; other site
983548004106	GAD domain; Region: GAD; pfam02938
983548004107	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
983548004108	active site
983548004109	motif 3; other site
983548004110	Protein of unknown function (DUF3050); Region: DUF3050; pfam11251
983548004111	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
983548004112	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
983548004113	active site
983548004114	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
983548004115	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
983548004116	Ligand binding site; other site
983548004117	Putative Catalytic site; other site
983548004118	DXD motif; other site
983548004119	dihydroorotase; Reviewed; Region: PRK09236
983548004120	Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318
983548004121	active site
983548004122	Domain of unknown function (DUF4296); Region: DUF4296; pfam14129
983548004123	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548004124	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
983548004125	NAD(P) binding site [chemical binding]; other site
983548004126	active site
983548004127	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
983548004128	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
983548004129	active site
983548004130	HIGH motif; other site
983548004131	dimer interface [polypeptide binding]; other site
983548004132	KMSKS motif; other site
983548004133	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
983548004134	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
983548004135	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
983548004136	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
983548004137	Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443
983548004138	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
983548004139	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548004140	active site
983548004141	phosphorylation site [posttranslational modification]
983548004142	intermolecular recognition site; other site
983548004143	dimerization interface [polypeptide binding]; other site
983548004144	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
983548004145	DNA binding site [nucleotide binding]
983548004146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548004147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548004148	dimer interface [polypeptide binding]; other site
983548004149	phosphorylation site [posttranslational modification]
983548004150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548004151	ATP binding site [chemical binding]; other site
983548004152	Mg2+ binding site [ion binding]; other site
983548004153	G-X-G motif; other site
983548004154	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
983548004155	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548004156	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548004157	S-adenosylmethionine binding site [chemical binding]; other site
983548004158	LysE type translocator; Region: LysE; cl00565
983548004159	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
983548004160	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
983548004161	DNA binding site [nucleotide binding]
983548004162	active site
983548004163	Domain of unknown function DUF59; Region: DUF59; pfam01883
983548004164	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
983548004165	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
983548004166	Walker A motif; other site
983548004167	NifU-like domain; Region: NifU; cl00484
983548004168	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
983548004169	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
983548004170	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548004171	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
983548004172	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
983548004173	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
983548004174	putative active site [active]
983548004175	putative metal binding site [ion binding]; other site
983548004176	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
983548004177	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
983548004178	ATP binding site [chemical binding]; other site
983548004179	substrate interface [chemical binding]; other site
983548004180	Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452
983548004181	Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462
983548004182	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548004183	non-specific DNA binding site [nucleotide binding]; other site
983548004184	salt bridge; other site
983548004185	sequence-specific DNA binding site [nucleotide binding]; other site
983548004186	Domain of unknown function (DUF955); Region: DUF955; pfam06114
983548004187	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
983548004188	Protein of unknown function (DUF3078); Region: DUF3078; pfam11276
983548004189	Protein of unknown function (DUF2480); Region: DUF2480; pfam10652
983548004190	Domain of unknown function DUF59; Region: DUF59; cl00941
983548004191	Fe-S metabolism associated domain; Region: SufE; cl00951
983548004192	META domain; Region: META; pfam03724
983548004193	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
983548004194	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548004195	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
983548004196	Coenzyme A binding pocket [chemical binding]; other site
983548004197	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
983548004198	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
983548004199	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548004200	catalytic residue [active]
983548004201	FeS assembly protein SufD; Region: sufD; TIGR01981
983548004202	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
983548004203	FeS assembly ATPase SufC; Region: sufC; TIGR01978
983548004204	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
983548004205	Walker A/P-loop; other site
983548004206	ATP binding site [chemical binding]; other site
983548004207	Q-loop/lid; other site
983548004208	ABC transporter signature motif; other site
983548004209	Walker B; other site
983548004210	D-loop; other site
983548004211	H-loop/switch region; other site
983548004212	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
983548004213	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548004214	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
983548004215	putative ABC transporter; Region: ycf24; CHL00085
983548004216	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
983548004217	ATP cone domain; Region: ATP-cone; pfam03477
983548004218	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
983548004219	dimer interface [polypeptide binding]; other site
983548004220	putative radical transfer pathway; other site
983548004221	diiron center [ion binding]; other site
983548004222	tyrosyl radical; other site
983548004223	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09102
983548004224	Class I ribonucleotide reductase; Region: RNR_I; cd01679
983548004225	active site
983548004226	dimer interface [polypeptide binding]; other site
983548004227	catalytic residues [active]
983548004228	effector binding site; other site
983548004229	R2 peptide binding site; other site
983548004230	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
983548004231	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
983548004232	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
983548004233	N-terminal plug; other site
983548004234	ligand-binding site [chemical binding]; other site
983548004235	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
983548004236	hypothetical protein; Provisional; Region: PRK10621
983548004237	Trehalose utilisation; Region: ThuA; pfam06283
983548004238	thiamine-monophosphate kinase; Region: thiL; TIGR01379
983548004239	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
983548004240	ATP binding site [chemical binding]; other site
983548004241	dimerization interface [polypeptide binding]; other site
983548004242	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
983548004243	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
983548004244	Family description; Region: ACT_7; pfam13840
983548004245	aspartate kinase III; Validated; Region: PRK09084
983548004246	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
983548004247	nucleotide binding site [chemical binding]; other site
983548004248	substrate binding site [chemical binding]; other site
983548004249	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
983548004250	dimer interface [polypeptide binding]; other site
983548004251	allosteric regulatory binding pocket; other site
983548004252	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
983548004253	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
983548004254	proline aminopeptidase P II; Provisional; Region: PRK10879
983548004255	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
983548004256	active site
983548004257	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
983548004258	active site clefts [active]
983548004259	zinc binding site [ion binding]; other site
983548004260	dimer interface [polypeptide binding]; other site
983548004261	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
983548004262	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
983548004263	putative Iron-sulfur protein interface [polypeptide binding]; other site
983548004264	proximal heme binding site [chemical binding]; other site
983548004265	distal heme binding site [chemical binding]; other site
983548004266	putative dimer interface [polypeptide binding]; other site
983548004267	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
983548004268	L-aspartate oxidase; Provisional; Region: PRK06175
983548004269	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
983548004270	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
983548004271	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
983548004272	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
983548004273	Phosphate transporter family; Region: PHO4; pfam01384
983548004274	Phosphate transporter family; Region: PHO4; cl00396
983548004275	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
983548004276	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548004277	TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782
983548004278	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548004279	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548004280	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096
983548004281	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
983548004282	PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818
983548004283	PA/protease or protease-like domain interface [polypeptide binding]; other site
983548004284	Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128
983548004285	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
983548004286	Zn binding site [ion binding]; other site
983548004287	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548004288	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
983548004289	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
983548004290	TPP-binding site; other site
983548004291	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
983548004292	PYR/PP interface [polypeptide binding]; other site
983548004293	dimer interface [polypeptide binding]; other site
983548004294	TPP binding site [chemical binding]; other site
983548004295	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
983548004296	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
983548004297	nucleoside/Zn binding site; other site
983548004298	dimer interface [polypeptide binding]; other site
983548004299	catalytic motif [active]
983548004300	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
983548004301	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
983548004302	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548004303	FeS/SAM binding site; other site
983548004304	Predicted amidohydrolase [General function prediction only]; Region: COG0388
983548004305	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
983548004306	putative active site [active]
983548004307	catalytic triad [active]
983548004308	putative dimer interface [polypeptide binding]; other site
983548004309	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
983548004310	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
983548004311	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
983548004312	RNA binding surface [nucleotide binding]; other site
983548004313	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
983548004314	active site
983548004315	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
983548004316	Ligand binding site; other site
983548004317	Putative Catalytic site; other site
983548004318	DXD motif; other site
983548004319	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
983548004320	Lipid A Biosynthesis N-terminal domain; Region: LAB_N; cl01627
983548004321	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
983548004322	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
983548004323	carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459
983548004324	Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437
983548004325	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
983548004326	DXD motif; other site
983548004327	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
983548004328	Ligand binding site; other site
983548004329	Putative Catalytic site; other site
983548004330	DXD motif; other site
983548004331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
983548004332	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
983548004333	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
983548004334	transcription elongation factor GreA; Region: greA; TIGR01462
983548004335	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
983548004336	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548004337	Walker A/P-loop; other site
983548004338	ATP binding site [chemical binding]; other site
983548004339	Q-loop/lid; other site
983548004340	ABC transporter signature motif; other site
983548004341	Walker B; other site
983548004342	D-loop; other site
983548004343	H-loop/switch region; other site
983548004344	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
983548004345	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
983548004346	ligand binding site [chemical binding]; other site
983548004347	phosphodiesterase YaeI; Provisional; Region: PRK11340
983548004348	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
983548004349	putative active site [active]
983548004350	putative metal binding site [ion binding]; other site
983548004351	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548004352	catalytic residues [active]
983548004353	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
983548004354	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
983548004355	NodB motif; other site
983548004356	active site
983548004357	catalytic site [active]
983548004358	metal binding site [ion binding]; metal-binding site
983548004359	Integral membrane protein TerC family; Region: TerC; cl10468
983548004360	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
983548004361	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
983548004362	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
983548004363	Conserved TM helix; Region: TM_helix; pfam05552
983548004364	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548004365	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
983548004366	transmembrane helices; other site
983548004367	TrkA-C domain; Region: TrkA_C; pfam02080
983548004368	TrkA-C domain; Region: TrkA_C; pfam02080
983548004369	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
983548004370	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
983548004371	universal stress protein UspE; Provisional; Region: PRK11175
983548004372	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548004373	Ligand Binding Site [chemical binding]; other site
983548004374	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548004375	Ligand Binding Site [chemical binding]; other site
983548004376	ribosome maturation protein RimP; Reviewed; Region: PRK00092
983548004377	hypothetical protein; Validated; Region: PRK02001
983548004378	heptamer interface [polypeptide binding]; other site
983548004379	Sm1 motif; other site
983548004380	hexamer interface [polypeptide binding]; other site
983548004381	RNA binding site [nucleotide binding]; other site
983548004382	Sm2 motif; other site
983548004383	transcription termination factor NusA; Region: NusA; TIGR01953
983548004384	NusA N-terminal domain; Region: NusA_N; pfam08529
983548004385	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
983548004386	RNA binding site [nucleotide binding]; other site
983548004387	homodimer interface [polypeptide binding]; other site
983548004388	NusA-like KH domain; Region: KH_5; pfam13184
983548004389	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
983548004390	G-X-X-G motif; other site
983548004391	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
983548004392	translation initiation factor IF-2; Region: IF-2; TIGR00487
983548004393	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
983548004394	G1 box; other site
983548004395	putative GEF interaction site [polypeptide binding]; other site
983548004396	GTP/Mg2+ binding site [chemical binding]; other site
983548004397	Switch I region; other site
983548004398	G2 box; other site
983548004399	G3 box; other site
983548004400	Switch II region; other site
983548004401	G4 box; other site
983548004402	G5 box; other site
983548004403	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
983548004404	Translation-initiation factor 2; Region: IF-2; pfam11987
983548004405	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
983548004406	Sporulation related domain; Region: SPOR; pfam05036
983548004407	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
983548004408	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
983548004409	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
983548004410	heme-binding residues [chemical binding]; other site
983548004411	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
983548004412	heme-binding residues [chemical binding]; other site
983548004413	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
983548004414	molybdopterin cofactor binding site; other site
983548004415	The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784
983548004416	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
983548004417	4Fe-4S binding domain; Region: Fer4; cl02805
983548004418	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
983548004419	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
983548004420	Uncharacterized conserved protein [Function unknown]; Region: COG3743
983548004421	Protein of unknown function (DUF3341); Region: DUF3341; pfam11821
983548004422	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
983548004423	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
983548004424	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
983548004425	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
983548004426	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
983548004427	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
983548004428	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
983548004429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548004430	Walker A motif; other site
983548004431	ATP binding site [chemical binding]; other site
983548004432	Walker B motif; other site
983548004433	arginine finger; other site
983548004434	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
983548004435	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
983548004436	Cytochrome P450; Region: p450; cl12078
983548004437	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
983548004438	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
983548004439	4Fe-4S binding domain; Region: Fer4; pfam00037
983548004440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548004441	Major Facilitator Superfamily; Region: MFS_1; pfam07690
983548004442	putative substrate translocation pore; other site
983548004443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548004444	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
983548004445	putative substrate translocation pore; other site
983548004446	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
983548004447	Trehalase; Region: Trehalase; cl17346
983548004448	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
983548004449	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
983548004450	substrate binding site [chemical binding]; other site
983548004451	ATP binding site [chemical binding]; other site
983548004452	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
983548004453	Malic enzyme, N-terminal domain; Region: malic; pfam00390
983548004454	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
983548004455	putative NAD(P) binding site [chemical binding]; other site
983548004456	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
983548004457	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
983548004458	RuvA N terminal domain; Region: RuvA_N; pfam01330
983548004459	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
983548004460	Motility related/secretion protein; Region: SprA_N; pfam14349
983548004461	cell surface protein SprA; Region: surface_SprA; TIGR04189
983548004462	Motility related/secretion protein; Region: SprA_N; pfam14349
983548004463	Motility related/secretion protein; Region: SprA_N; pfam14349
983548004464	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
983548004465	lipoyl attachment site [posttranslational modification]; other site
983548004466	Predicted integral membrane protein [Function unknown]; Region: COG5652
983548004467	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
983548004468	Gram-negative bacterial tonB protein; Region: TonB; cl10048
983548004469	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
983548004470	active site
983548004471	metal binding site [ion binding]; metal-binding site
983548004472	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548004473	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
983548004474	UbiA prenyltransferase family; Region: UbiA; pfam01040
983548004475	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
983548004476	Subunit I/III interface [polypeptide binding]; other site
983548004477	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
983548004478	Subunit I/III interface [polypeptide binding]; other site
983548004479	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211
983548004480	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626
983548004481	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
983548004482	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
983548004483	Cu(I) binding site [ion binding]; other site
983548004484	Protein of unknown function (DUF420); Region: DUF420; pfam04238
983548004485	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548004486	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548004487	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548004488	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548004489	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548004490	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
983548004491	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
983548004492	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
983548004493	Walker A/P-loop; other site
983548004494	ATP binding site [chemical binding]; other site
983548004495	Q-loop/lid; other site
983548004496	ABC transporter signature motif; other site
983548004497	Walker B; other site
983548004498	D-loop; other site
983548004499	H-loop/switch region; other site
983548004500	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
983548004501	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
983548004502	FtsX-like permease family; Region: FtsX; pfam02687
983548004503	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
983548004504	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
983548004505	FtsX-like permease family; Region: FtsX; pfam02687
983548004506	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
983548004507	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
983548004508	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548004509	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
983548004510	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
983548004511	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
983548004512	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548004513	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
983548004514	Glycoprotease family; Region: Peptidase_M22; pfam00814
983548004515	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548004516	Conserved TM helix; Region: TM_helix; pfam05552
983548004517	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548004518	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
983548004519	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
983548004520	catalytic residues [active]
983548004521	Dodecin; Region: Dodecin; pfam07311
983548004522	Repair protein; Region: Repair_PSII; pfam04536
983548004523	Repair protein; Region: Repair_PSII; pfam04536
983548004524	LemA family; Region: LemA; cl00742
983548004525	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
983548004526	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
983548004527	DNA binding residues [nucleotide binding]
983548004528	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
983548004529	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548004530	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
983548004531	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
983548004532	motif 1; other site
983548004533	active site
983548004534	motif 2; other site
983548004535	motif 3; other site
983548004536	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
983548004537	GSCFA family; Region: GSCFA; pfam08885
983548004538	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004539	active site residue [active]
983548004540	phenylalanine 4-monooxygenase; Provisional; Region: PRK14056
983548004541	Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361
983548004542	cofactor binding site; other site
983548004543	metal binding site [ion binding]; metal-binding site
983548004544	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
983548004545	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
983548004546	substrate binding site [chemical binding]; other site
983548004547	oxyanion hole (OAH) forming residues; other site
983548004548	trimer interface [polypeptide binding]; other site
983548004549	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
983548004550	1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515
983548004551	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
983548004552	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548004553	catalytic residue [active]
983548004554	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
983548004555	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548004556	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
983548004557	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
983548004558	inhibitor-cofactor binding pocket; inhibition site
983548004559	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548004560	catalytic residue [active]
983548004561	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
983548004562	active site
983548004563	Predicted membrane protein [Function unknown]; Region: COG4682
983548004564	yiaA/B two helix domain; Region: YiaAB; pfam05360
983548004565	yiaA/B two helix domain; Region: YiaAB; pfam05360
983548004566	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
983548004567	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
983548004568	catalytic residues [active]
983548004569	EthD domain; Region: EthD; cl17553
983548004570	short chain dehydrogenase; Validated; Region: PRK08264
983548004571	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548004572	NAD(P) binding site [chemical binding]; other site
983548004573	active site
983548004574	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
983548004575	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
983548004576	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
983548004577	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
983548004578	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
983548004579	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
983548004580	active site
983548004581	purine riboside binding site [chemical binding]; other site
983548004582	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
983548004583	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
983548004584	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
983548004585	Family of unknown function (DUF695); Region: DUF695; pfam05117
983548004586	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
983548004587	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
983548004588	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
983548004589	dimer interface [polypeptide binding]; other site
983548004590	putative anticodon binding site; other site
983548004591	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
983548004592	motif 1; other site
983548004593	active site
983548004594	motif 2; other site
983548004595	motif 3; other site
983548004596	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
983548004597	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
983548004598	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
983548004599	RNA/DNA hybrid binding site [nucleotide binding]; other site
983548004600	active site
983548004601	Domain of unknown function (DUF4289); Region: DUF4289; pfam14121
983548004602	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
983548004603	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
983548004604	active site
983548004605	PHP Thumb interface [polypeptide binding]; other site
983548004606	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
983548004607	generic binding surface I; other site
983548004608	generic binding surface II; other site
983548004609	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
983548004610	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
983548004611	active site
983548004612	DNA binding site [nucleotide binding]
983548004613	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
983548004614	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
983548004615	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
983548004616	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
983548004617	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
983548004618	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
983548004619	EamA-like transporter family; Region: EamA; pfam00892
983548004620	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
983548004621	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
983548004622	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
983548004623	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
983548004624	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
983548004625	rod shape-determining protein MreC; Provisional; Region: PRK13922
983548004626	rod shape-determining protein MreC; Region: MreC; pfam04085
983548004627	rod shape-determining protein MreB; Provisional; Region: PRK13927
983548004628	MreB and similar proteins; Region: MreB_like; cd10225
983548004629	nucleotide binding site [chemical binding]; other site
983548004630	Mg binding site [ion binding]; other site
983548004631	putative protofilament interaction site [polypeptide binding]; other site
983548004632	RodZ interaction site [polypeptide binding]; other site
983548004633	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
983548004634	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
983548004635	purine monophosphate binding site [chemical binding]; other site
983548004636	dimer interface [polypeptide binding]; other site
983548004637	putative catalytic residues [active]
983548004638	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
983548004639	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
983548004640	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
983548004641	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
983548004642	FtsX-like permease family; Region: FtsX; pfam02687
983548004643	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
983548004644	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
983548004645	exosortase family protein XrtF; Region: exoso_Fjoh_1448; TIGR04128
983548004646	exosortase F-associated protein; Region: flavo_near_exo; TIGR04127
983548004647	Protein of unknown function (DUF3347); Region: DUF3347; pfam11827
983548004648	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768
983548004649	Heavy-metal-associated domain; Region: HMA; pfam00403
983548004650	metal-binding site [ion binding]
983548004651	NHL repeat; Region: NHL; pfam01436
983548004652	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
983548004653	metal-binding site [ion binding]
983548004654	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
983548004655	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
983548004656	ring oligomerisation interface [polypeptide binding]; other site
983548004657	ATP/Mg binding site [chemical binding]; other site
983548004658	stacking interactions; other site
983548004659	hinge regions; other site
983548004660	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
983548004661	oligomerisation interface [polypeptide binding]; other site
983548004662	mobile loop; other site
983548004663	roof hairpin; other site
983548004664	Lipopolysaccharide-assembly; Region: LptE; cl01125
983548004665	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548004666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548004667	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
983548004668	Walker A motif; other site
983548004669	ATP binding site [chemical binding]; other site
983548004670	Walker B motif; other site
983548004671	arginine finger; other site
983548004672	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
983548004673	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14329
983548004674	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
983548004675	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548004676	FeS/SAM binding site; other site
983548004677	TRAM domain; Region: TRAM; pfam01938
983548004678	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; cl01409
983548004679	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
983548004680	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
983548004681	active site
983548004682	interdomain interaction site; other site
983548004683	putative metal-binding site [ion binding]; other site
983548004684	nucleotide binding site [chemical binding]; other site
983548004685	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
983548004686	domain I; other site
983548004687	DNA binding groove [nucleotide binding]
983548004688	phosphate binding site [ion binding]; other site
983548004689	domain II; other site
983548004690	domain III; other site
983548004691	nucleotide binding site [chemical binding]; other site
983548004692	catalytic site [active]
983548004693	domain IV; other site
983548004694	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
983548004695	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
983548004696	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
983548004697	putative active site [active]
983548004698	putative metal binding site [ion binding]; other site
983548004699	gliding motility-associated lipoprotein GldK; Region: GldK; TIGR03525
983548004700	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
983548004701	gliding motility-associated lipoprotein GldJ; Region: GldJ; TIGR03524
983548004702	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
983548004703	gliding motility-associated protein GldL; Region: GldL_gliding; TIGR03513
983548004704	gliding motility-associated protein GldM; Region: GldM_gliding; TIGR03517
983548004705	GldM N-terminal domain; Region: GldM_N; pfam12081
983548004706	GldM C-terminal domain; Region: GldM_C; pfam12080
983548004707	gliding motility associated protien GldN; Region: GldN; TIGR03523
983548004708	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
983548004709	Ca2+-dependent lipid-binding protein, contains C2 domain [General function prediction only]; Region: COG5038
983548004710	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
983548004711	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548004712	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548004713	ABC transporter; Region: ABC_tran_2; pfam12848
983548004714	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548004715	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
983548004716	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548004717	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
983548004718	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
983548004719	Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255
983548004720	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
983548004721	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
983548004722	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
983548004723	active site
983548004724	catalytic residues [active]
983548004725	DNA binding site [nucleotide binding]
983548004726	Int/Topo IB signature motif; other site
983548004727	AAA domain; Region: AAA_25; pfam13481
983548004728	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
983548004729	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
983548004730	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548004731	ATP binding site [chemical binding]; other site
983548004732	putative Mg++ binding site [ion binding]; other site
983548004733	HsdM N-terminal domain; Region: HsdM_N; pfam12161
983548004734	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
983548004735	Methyltransferase domain; Region: Methyltransf_26; pfam13659
983548004736	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
983548004737	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
983548004738	AAA domain; Region: AAA_21; pfam13304
983548004739	NADP-dependent malic enzyme; Provisional; Region: PTZ00317
983548004740	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
983548004741	ATP-grasp domain; Region: ATP-grasp_4; cl17255
983548004742	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251
983548004743	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
983548004744	putative active site [active]
983548004745	Zn binding site [ion binding]; other site
983548004746	Predicted transporter component [General function prediction only]; Region: COG2391
983548004747	Sulphur transport; Region: Sulf_transp; pfam04143
983548004748	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
983548004749	Sulphur transport; Region: Sulf_transp; pfam04143
983548004750	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
983548004751	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
983548004752	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
983548004753	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548004754	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
983548004755	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
983548004756	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
983548004757	dimerization interface [polypeptide binding]; other site
983548004758	DPS ferroxidase diiron center [ion binding]; other site
983548004759	ion pore; other site
983548004760	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548004761	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004762	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004763	active site residue [active]
983548004764	peroxiredoxin; Provisional; Region: PRK13189
983548004765	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
983548004766	dimer interface [polypeptide binding]; other site
983548004767	decamer (pentamer of dimers) interface [polypeptide binding]; other site
983548004768	catalytic triad [active]
983548004769	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
983548004770	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
983548004771	dimer interface [polypeptide binding]; other site
983548004772	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548004773	catalytic residue [active]
983548004774	serine O-acetyltransferase; Region: cysE; TIGR01172
983548004775	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
983548004776	trimer interface [polypeptide binding]; other site
983548004777	active site
983548004778	substrate binding site [chemical binding]; other site
983548004779	CoA binding site [chemical binding]; other site
983548004780	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
983548004781	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
983548004782	active site
983548004783	zinc binding site [ion binding]; other site
983548004784	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
983548004785	Cytochrome c; Region: Cytochrom_C; pfam00034
983548004786	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
983548004787	Domain of unknown function (DUF202); Region: DUF202; pfam02656
983548004788	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
983548004789	metal-binding site [ion binding]
983548004790	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004791	active site residue [active]
983548004792	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004793	active site residue [active]
983548004794	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
983548004795	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004796	active site residue [active]
983548004797	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004798	active site residue [active]
983548004799	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548004800	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004801	active site residue [active]
983548004802	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548004803	active site residue [active]
983548004804	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
983548004805	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
983548004806	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548004807	ligand binding site [chemical binding]; other site
983548004808	flexible hinge region; other site
983548004809	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
983548004810	putative switch regulator; other site
983548004811	non-specific DNA interactions [nucleotide binding]; other site
983548004812	DNA binding site [nucleotide binding]
983548004813	sequence specific DNA binding site [nucleotide binding]; other site
983548004814	putative cAMP binding site [chemical binding]; other site
983548004815	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
983548004816	Outer membrane efflux protein; Region: OEP; pfam02321
983548004817	Outer membrane efflux protein; Region: OEP; pfam02321
983548004818	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
983548004819	HlyD family secretion protein; Region: HlyD_3; pfam13437
983548004820	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
983548004821	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
983548004822	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
983548004823	GTPase Era; Reviewed; Region: era; PRK00089
983548004824	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
983548004825	G1 box; other site
983548004826	GTP/Mg2+ binding site [chemical binding]; other site
983548004827	Switch I region; other site
983548004828	G2 box; other site
983548004829	Switch II region; other site
983548004830	G3 box; other site
983548004831	G4 box; other site
983548004832	G5 box; other site
983548004833	KH domain; Region: KH_2; pfam07650
983548004834	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
983548004835	Protein of unknown function (DUF4199); Region: DUF4199; pfam13858
983548004836	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
983548004837	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
983548004838	Uncharacterized conserved protein [Function unknown]; Region: COG3743
983548004839	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
983548004840	GH3 auxin-responsive promoter; Region: GH3; pfam03321
983548004841	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
983548004842	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
983548004843	active site
983548004844	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
983548004845	aromatic chitin/cellulose binding site residues [chemical binding]; other site
983548004846	Carbohydrate binding domain; Region: CBM_5_12; pfam02839
983548004847	aromatic chitin/cellulose binding site residues [chemical binding]; other site
983548004848	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
983548004849	catalytic motif [active]
983548004850	Catalytic residue [active]
983548004851	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
983548004852	active site
983548004853	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
983548004854	putative acyl-acceptor binding pocket; other site
983548004855	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
983548004856	active site
983548004857	homodimer interface [polypeptide binding]; other site
983548004858	flagellin; Validated; Region: PRK08026
983548004859	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548004860	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548004861	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548004862	binding surface
983548004863	TPR motif; other site
983548004864	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548004865	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548004866	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548004867	ligand binding site [chemical binding]; other site
983548004868	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
983548004869	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
983548004870	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
983548004871	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548004872	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
983548004873	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
983548004874	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
983548004875	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
983548004876	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
983548004877	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
983548004878	Flavin reductase like domain; Region: Flavin_Reduct; pfam01613
983548004879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548004880	S-adenosylmethionine binding site [chemical binding]; other site
983548004881	methionine sulfoxide reductase A; Provisional; Region: PRK14054
983548004882	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
983548004883	Putative zinc ribbon domain; Region: DUF164; pfam02591
983548004884	Uncharacterized conserved protein [Function unknown]; Region: COG0327
983548004885	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
983548004886	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
983548004887	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
983548004888	Uncharacterized conserved protein [Function unknown]; Region: COG0327
983548004889	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
983548004890	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
983548004891	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548004892	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548004893	dimer interface [polypeptide binding]; other site
983548004894	phosphorylation site [posttranslational modification]
983548004895	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548004896	ATP binding site [chemical binding]; other site
983548004897	Mg2+ binding site [ion binding]; other site
983548004898	G-X-G motif; other site
983548004899	Response regulator receiver domain; Region: Response_reg; pfam00072
983548004900	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548004901	active site
983548004902	phosphorylation site [posttranslational modification]
983548004903	intermolecular recognition site; other site
983548004904	dimerization interface [polypeptide binding]; other site
983548004905	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
983548004906	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
983548004907	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
983548004908	lipoyl synthase; Provisional; Region: PRK05481
983548004909	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548004910	FeS/SAM binding site; other site
983548004911	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
983548004912	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
983548004913	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
983548004914	FtsH Extracellular; Region: FtsH_ext; pfam06480
983548004915	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
983548004916	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548004917	Walker A motif; other site
983548004918	ATP binding site [chemical binding]; other site
983548004919	Walker B motif; other site
983548004920	arginine finger; other site
983548004921	Peptidase family M41; Region: Peptidase_M41; pfam01434
983548004922	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
983548004923	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
983548004924	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
983548004925	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
983548004926	Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a...; Region: ACBP; cl00221
983548004927	acyl-CoA binding pocket [chemical binding]; other site
983548004928	CoA binding site [chemical binding]; other site
983548004929	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
983548004930	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
983548004931	active site
983548004932	HIGH motif; other site
983548004933	nucleotide binding site [chemical binding]; other site
983548004934	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
983548004935	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
983548004936	active site
983548004937	KMSKS motif; other site
983548004938	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
983548004939	tRNA binding surface [nucleotide binding]; other site
983548004940	anticodon binding site; other site
983548004941	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
983548004942	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
983548004943	aspartate aminotransferase; Provisional; Region: PRK07568
983548004944	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
983548004945	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548004946	homodimer interface [polypeptide binding]; other site
983548004947	catalytic residue [active]
983548004948	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
983548004949	FAD binding domain; Region: FAD_binding_4; pfam01565
983548004950	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
983548004951	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
983548004952	Fasciclin domain; Region: Fasciclin; pfam02469
983548004953	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
983548004954	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548004955	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548004956	DNA binding residues [nucleotide binding]
983548004957	putative anti-sigmaE protein; Provisional; Region: PRK13920
983548004958	Anti-sigma-K factor rskA; Region: RskA; pfam10099
983548004959	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
983548004960	active site
983548004961	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548004962	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548004963	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548004964	DNA binding residues [nucleotide binding]
983548004965	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
983548004966	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
983548004967	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
983548004968	Predicted permeases [General function prediction only]; Region: COG0795
983548004969	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
983548004970	EamA-like transporter family; Region: EamA; pfam00892
983548004971	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
983548004972	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
983548004973	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
983548004974	replicative DNA helicase; Region: DnaB; TIGR00665
983548004975	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
983548004976	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
983548004977	Walker A motif; other site
983548004978	ATP binding site [chemical binding]; other site
983548004979	Walker B motif; other site
983548004980	DNA binding loops [nucleotide binding]
983548004981	Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540
983548004982	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
983548004983	putative active site [active]
983548004984	putative metal binding site [ion binding]; other site
983548004985	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
983548004986	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
983548004987	asparagine synthetase B; Provisional; Region: asnB; PRK09431
983548004988	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
983548004989	active site
983548004990	dimer interface [polypeptide binding]; other site
983548004991	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
983548004992	Ligand Binding Site [chemical binding]; other site
983548004993	Molecular Tunnel; other site
983548004994	Major royal jelly protein; Region: MRJP; pfam03022
983548004995	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
983548004996	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
983548004997	hypothetical protein; Reviewed; Region: PRK00024
983548004998	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
983548004999	MPN+ (JAMM) motif; other site
983548005000	Zinc-binding site [ion binding]; other site
983548005001	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u7; cd10931
983548005002	putative active site [active]
983548005003	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
983548005004	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548005005	motif II; other site
983548005006	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299
983548005007	heme binding pocket [chemical binding]; other site
983548005008	recombination factor protein RarA; Reviewed; Region: PRK13342
983548005009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548005010	Walker A motif; other site
983548005011	ATP binding site [chemical binding]; other site
983548005012	Walker B motif; other site
983548005013	arginine finger; other site
983548005014	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
983548005015	Rhomboid family; Region: Rhomboid; pfam01694
983548005016	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
983548005017	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
983548005018	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
983548005019	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
983548005020	starch binding outer membrane protein SusD; Region: SusD; cl17845
983548005021	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548005022	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548005023	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
983548005024	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548005025	Starch-binding associating with outer membrane; Region: SusD-like_2; pfam12771
983548005026	starch binding outer membrane protein SusD; Region: SusD; cl17845
983548005027	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548005028	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548005029	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
983548005030	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548005031	starch binding outer membrane protein SusD; Region: SusD; cd08977
983548005032	TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056
983548005033	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548005034	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
983548005035	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548005036	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
983548005037	S17 interaction site [polypeptide binding]; other site
983548005038	S8 interaction site; other site
983548005039	16S rRNA interaction site [nucleotide binding]; other site
983548005040	streptomycin interaction site [chemical binding]; other site
983548005041	23S rRNA interaction site [nucleotide binding]; other site
983548005042	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
983548005043	30S ribosomal protein S7; Validated; Region: PRK05302
983548005044	elongation factor G; Reviewed; Region: PRK12739
983548005045	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
983548005046	G1 box; other site
983548005047	putative GEF interaction site [polypeptide binding]; other site
983548005048	GTP/Mg2+ binding site [chemical binding]; other site
983548005049	Switch I region; other site
983548005050	G2 box; other site
983548005051	G3 box; other site
983548005052	Switch II region; other site
983548005053	G4 box; other site
983548005054	G5 box; other site
983548005055	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
983548005056	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
983548005057	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
983548005058	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
983548005059	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
983548005060	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
983548005061	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
983548005062	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
983548005063	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
983548005064	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
983548005065	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
983548005066	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
983548005067	putative translocon binding site; other site
983548005068	protein-rRNA interface [nucleotide binding]; other site
983548005069	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
983548005070	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
983548005071	G-X-X-G motif; other site
983548005072	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
983548005073	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
983548005074	23S rRNA interface [nucleotide binding]; other site
983548005075	5S rRNA interface [nucleotide binding]; other site
983548005076	putative antibiotic binding site [chemical binding]; other site
983548005077	L25 interface [polypeptide binding]; other site
983548005078	L27 interface [polypeptide binding]; other site
983548005079	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
983548005080	23S rRNA interface [nucleotide binding]; other site
983548005081	putative translocon interaction site; other site
983548005082	signal recognition particle (SRP54) interaction site; other site
983548005083	L23 interface [polypeptide binding]; other site
983548005084	trigger factor interaction site; other site
983548005085	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
983548005086	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
983548005087	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
983548005088	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
983548005089	RNA binding site [nucleotide binding]; other site
983548005090	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
983548005091	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
983548005092	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
983548005093	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
983548005094	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
983548005095	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
983548005096	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
983548005097	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
983548005098	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
983548005099	23S rRNA interface [nucleotide binding]; other site
983548005100	L21e interface [polypeptide binding]; other site
983548005101	5S rRNA interface [nucleotide binding]; other site
983548005102	L27 interface [polypeptide binding]; other site
983548005103	L5 interface [polypeptide binding]; other site
983548005104	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
983548005105	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
983548005106	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
983548005107	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
983548005108	23S rRNA binding site [nucleotide binding]; other site
983548005109	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
983548005110	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
983548005111	SecY translocase; Region: SecY; pfam00344
983548005112	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
983548005113	rRNA binding site [nucleotide binding]; other site
983548005114	predicted 30S ribosome binding site; other site
983548005115	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
983548005116	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
983548005117	30S ribosomal protein S13; Region: bact_S13; TIGR03631
983548005118	30S ribosomal protein S11; Validated; Region: PRK05309
983548005119	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
983548005120	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
983548005121	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
983548005122	RNA binding surface [nucleotide binding]; other site
983548005123	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
983548005124	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
983548005125	alphaNTD homodimer interface [polypeptide binding]; other site
983548005126	alphaNTD - beta interaction site [polypeptide binding]; other site
983548005127	alphaNTD - beta' interaction site [polypeptide binding]; other site
983548005128	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
983548005129	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
983548005130	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
983548005131	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
983548005132	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
983548005133	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
983548005134	catalytic site [active]
983548005135	subunit interface [polypeptide binding]; other site
983548005136	enolase; Provisional; Region: eno; PRK00077
983548005137	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
983548005138	dimer interface [polypeptide binding]; other site
983548005139	metal binding site [ion binding]; metal-binding site
983548005140	substrate binding pocket [chemical binding]; other site
983548005141	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
983548005142	dimer interface [polypeptide binding]; other site
983548005143	Citrate synthase; Region: Citrate_synt; pfam00285
983548005144	active site
983548005145	citrylCoA binding site [chemical binding]; other site
983548005146	NADH binding [chemical binding]; other site
983548005147	cationic pore residues; other site
983548005148	oxalacetate/citrate binding site [chemical binding]; other site
983548005149	coenzyme A binding site [chemical binding]; other site
983548005150	catalytic triad [active]
983548005151	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
983548005152	Amidinotransferase; Region: Amidinotransf; cl12043
983548005153	MepB protein; Region: MepB; cl01985
983548005154	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
983548005155	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
983548005156	ATP-grasp domain; Region: ATP-grasp; pfam02222
983548005157	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
983548005158	aspartate aminotransferase; Provisional; Region: PRK05764
983548005159	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
983548005160	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548005161	homodimer interface [polypeptide binding]; other site
983548005162	catalytic residue [active]
983548005163	Fatty acid desaturase; Region: FA_desaturase; pfam00487
983548005164	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
983548005165	putative di-iron ligands [ion binding]; other site
983548005166	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
983548005167	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
983548005168	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
983548005169	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
983548005170	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548005171	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548005172	DNA binding residues [nucleotide binding]
983548005173	Protein of unknown function (DUF724); Region: DUF724; pfam05266
983548005174	DNA primase; Validated; Region: dnaG; PRK05667
983548005175	CHC2 zinc finger; Region: zf-CHC2; cl17510
983548005176	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
983548005177	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
983548005178	active site
983548005179	metal binding site [ion binding]; metal-binding site
983548005180	interdomain interaction site; other site
983548005181	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
983548005182	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548005183	active site
983548005184	phosphorylation site [posttranslational modification]
983548005185	intermolecular recognition site; other site
983548005186	dimerization interface [polypeptide binding]; other site
983548005187	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
983548005188	DNA binding residues [nucleotide binding]
983548005189	dimerization interface [polypeptide binding]; other site
983548005190	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
983548005191	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
983548005192	homodimer interface [polypeptide binding]; other site
983548005193	NAD binding pocket [chemical binding]; other site
983548005194	ATP binding pocket [chemical binding]; other site
983548005195	Mg binding site [ion binding]; other site
983548005196	active-site loop [active]
983548005197	gliding motility-associated lipoprotein GldB; Region: GldB_lipo; TIGR03514
983548005198	gliding motility-associated protein GldC; Region: GldC; TIGR03515
983548005199	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
983548005200	G1 box; other site
983548005201	GTP/Mg2+ binding site [chemical binding]; other site
983548005202	Switch I region; other site
983548005203	G2 box; other site
983548005204	G3 box; other site
983548005205	Switch II region; other site
983548005206	G4 box; other site
983548005207	G5 box; other site
983548005208	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
983548005209	cell division protein MraZ; Reviewed; Region: PRK00326
983548005210	MraZ protein; Region: MraZ; pfam02381
983548005211	MraZ protein; Region: MraZ; pfam02381
983548005212	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
983548005213	MraW methylase family; Region: Methyltransf_5; cl17771
983548005214	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
983548005215	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
983548005216	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
983548005217	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
983548005218	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
983548005219	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
983548005220	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
983548005221	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
983548005222	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
983548005223	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
983548005224	Mg++ binding site [ion binding]; other site
983548005225	putative catalytic motif [active]
983548005226	putative substrate binding site [chemical binding]; other site
983548005227	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
983548005228	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
983548005229	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
983548005230	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
983548005231	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
983548005232	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
983548005233	active site
983548005234	homodimer interface [polypeptide binding]; other site
983548005235	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
983548005236	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
983548005237	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
983548005238	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
983548005239	Cell division protein FtsQ; Region: FtsQ; pfam03799
983548005240	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
983548005241	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
983548005242	nucleotide binding site [chemical binding]; other site
983548005243	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
983548005244	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
983548005245	Cell division protein FtsA; Region: FtsA; pfam14450
983548005246	Cell division GTPase [Cell division and chromosome partitioning]; Region: FtsZ; COG0206
983548005247	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
983548005248	nucleotide binding site [chemical binding]; other site
983548005249	SulA interaction site; other site
983548005250	Yqey-like protein; Region: YqeY; pfam09424
983548005251	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
983548005252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548005253	TPR motif; other site
983548005254	binding surface
983548005255	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
983548005256	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548005257	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548005258	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548005259	ligand binding site [chemical binding]; other site
983548005260	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
983548005261	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548005262	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
983548005263	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548005264	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
983548005265	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548005266	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
983548005267	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
983548005268	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
983548005269	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
983548005270	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
983548005271	Flavodoxin; Region: Flavodoxin_1; pfam00258
983548005272	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
983548005273	FAD binding pocket [chemical binding]; other site
983548005274	conserved FAD binding motif [chemical binding]; other site
983548005275	phosphate binding motif [ion binding]; other site
983548005276	beta-alpha-beta structure motif; other site
983548005277	NAD binding pocket [chemical binding]; other site
983548005278	RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646
983548005279	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548005280	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548005281	DNA binding residues [nucleotide binding]
983548005282	Anti-sigma-K factor rskA; Region: RskA; pfam10099
983548005283	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548005284	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548005285	binding surface
983548005286	TPR repeat; Region: TPR_11; pfam13414
983548005287	TPR motif; other site
983548005288	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
983548005289	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
983548005290	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
983548005291	Inhibitor of apoptosis-promoting Bax1; Region: Bax1-I; pfam01027
983548005292	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
983548005293	Transglycosylase; Region: Transgly; pfam00912
983548005294	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
983548005295	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
983548005296	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
983548005297	substrate binding site [chemical binding]; other site
983548005298	hexamer interface [polypeptide binding]; other site
983548005299	metal binding site [ion binding]; metal-binding site
983548005300	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
983548005301	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
983548005302	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548005303	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
983548005304	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548005305	DNA binding residues [nucleotide binding]
983548005306	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
983548005307	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
983548005308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
983548005309	S-adenosylmethionine binding site [chemical binding]; other site
983548005310	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548005311	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
983548005312	short chain dehydrogenase; Provisional; Region: PRK08339
983548005313	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
983548005314	putative NAD(P) binding site [chemical binding]; other site
983548005315	putative active site [active]
983548005316	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
983548005317	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
983548005318	NAD binding site [chemical binding]; other site
983548005319	catalytic residues [active]
983548005320	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
983548005321	homotrimer interaction site [polypeptide binding]; other site
983548005322	putative active site [active]
983548005323	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
983548005324	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
983548005325	Putative FMN-binding domain; Region: FMN_bind_2; pfam04299
983548005326	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548005327	kynureninase; Region: kynureninase; TIGR01814
983548005328	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548005329	catalytic residue [active]
983548005330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548005331	Major Facilitator Superfamily; Region: MFS_1; pfam07690
983548005332	putative substrate translocation pore; other site
983548005333	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
983548005334	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
983548005335	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
983548005336	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
983548005337	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
983548005338	Protein export membrane protein; Region: SecD_SecF; pfam02355
983548005339	malate dehydrogenase; Reviewed; Region: PRK06223
983548005340	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
983548005341	dimer interface [polypeptide binding]; other site
983548005342	NAD(P) binding site [chemical binding]; other site
983548005343	tetramer (dimer of dimers) interface [polypeptide binding]; other site
983548005344	substrate binding site [chemical binding]; other site
983548005345	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
983548005346	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548005347	ATP binding site [chemical binding]; other site
983548005348	Mg2+ binding site [ion binding]; other site
983548005349	G-X-G motif; other site
983548005350	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
983548005351	anchoring element; other site
983548005352	dimer interface [polypeptide binding]; other site
983548005353	ATP binding site [chemical binding]; other site
983548005354	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
983548005355	active site
983548005356	putative metal-binding site [ion binding]; other site
983548005357	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
983548005358	Protein of unknown function (DUF664); Region: DUF664; pfam04978
983548005359	DinB superfamily; Region: DinB_2; pfam12867
983548005360	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
983548005361	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
983548005362	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
983548005363	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
983548005364	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
983548005365	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
983548005366	amidase; Provisional; Region: PRK06828
983548005367	Amidase; Region: Amidase; cl11426
983548005368	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
983548005369	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
983548005370	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548005371	FeS/SAM binding site; other site
983548005372	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
983548005373	putative active site [active]
983548005374	Zn binding site [ion binding]; other site
983548005375	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
983548005376	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
983548005377	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
983548005378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
983548005379	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
983548005380	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548005381	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
983548005382	Metallopeptidase family M24; Region: Peptidase_M24; pfam00557
983548005383	active site
983548005384	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005385	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
983548005386	active site
983548005387	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
983548005388	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
983548005389	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548005390	NAD(P) binding site [chemical binding]; other site
983548005391	active site
983548005392	beta-carotene hydroxylase; Region: PLN02601
983548005393	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
983548005394	active site lid residues [active]
983548005395	substrate binding pocket [chemical binding]; other site
983548005396	catalytic residues [active]
983548005397	substrate-Mg2+ binding site; other site
983548005398	aspartate-rich region 1; other site
983548005399	aspartate-rich region 2; other site
983548005400	phytoene desaturase; Region: crtI_fam; TIGR02734
983548005401	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
983548005402	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
983548005403	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
983548005404	DNA binding residues [nucleotide binding]
983548005405	B12 binding domain; Region: B12-binding_2; pfam02607
983548005406	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
983548005407	Shikimate kinase; Region: SKI; pfam01202
983548005408	ADP binding site [chemical binding]; other site
983548005409	magnesium binding site [ion binding]; other site
983548005410	putative shikimate binding site; other site
983548005411	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548005412	active site
983548005413	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
983548005414	RNA binding surface [nucleotide binding]; other site
983548005415	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
983548005416	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548005417	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
983548005418	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
983548005419	PYR/PP interface [polypeptide binding]; other site
983548005420	dimer interface [polypeptide binding]; other site
983548005421	TPP binding site [chemical binding]; other site
983548005422	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
983548005423	transketolase; Reviewed; Region: PRK05899
983548005424	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
983548005425	TPP-binding site [chemical binding]; other site
983548005426	dimer interface [polypeptide binding]; other site
983548005427	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
983548005428	hydrophobic ligand binding site; other site
983548005429	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548005430	active site
983548005431	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
983548005432	active site
983548005433	Ap6A binding site [chemical binding]; other site
983548005434	nudix motif; other site
983548005435	metal binding site [ion binding]; metal-binding site
983548005436	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241
983548005437	putative active site [active]
983548005438	Zn binding site [ion binding]; other site
983548005439	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
983548005440	putative active site [active]
983548005441	Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700
983548005442	hypothetical protein; Validated; Region: PRK02101
983548005443	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
983548005444	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
983548005445	RNA binding surface [nucleotide binding]; other site
983548005446	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
983548005447	active site
983548005448	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
983548005449	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
983548005450	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
983548005451	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
983548005452	ATP-grasp domain; Region: ATP-grasp_4; cl17255
983548005453	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
983548005454	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
983548005455	active site
983548005456	(T/H)XGH motif; other site
983548005457	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
983548005458	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
983548005459	substrate binding site [chemical binding]; other site
983548005460	active site
983548005461	catalytic residues [active]
983548005462	heterodimer interface [polypeptide binding]; other site
983548005463	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
983548005464	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
983548005465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548005466	catalytic residue [active]
983548005467	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
983548005468	active site
983548005469	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
983548005470	active site
983548005471	ribulose/triose binding site [chemical binding]; other site
983548005472	phosphate binding site [ion binding]; other site
983548005473	substrate (anthranilate) binding pocket [chemical binding]; other site
983548005474	product (indole) binding pocket [chemical binding]; other site
983548005475	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
983548005476	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
983548005477	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
983548005478	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
983548005479	Glutamine amidotransferase class-I; Region: GATase; pfam00117
983548005480	glutamine binding [chemical binding]; other site
983548005481	catalytic triad [active]
983548005482	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
983548005483	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
983548005484	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
983548005485	YceI-like domain; Region: YceI; pfam04264
983548005486	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
983548005487	MarR family; Region: MarR; pfam01047
983548005488	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548005489	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548005490	catalytic residues [active]
983548005491	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
983548005492	putative catalytic residue [active]
983548005493	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
983548005494	Rhodanese-like domain; Region: Rhodanese; pfam00581
983548005495	active site residue [active]
983548005496	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548005497	active site residue [active]
983548005498	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548005499	active site residue [active]
983548005500	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548005501	active site residue [active]
983548005502	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
983548005503	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
983548005504	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
983548005505	TrkA-C domain; Region: TrkA_C; pfam02080
983548005506	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
983548005507	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
983548005508	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
983548005509	active site
983548005510	catalytic residues [active]
983548005511	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
983548005512	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
983548005513	Protein of unknown function (DUF3703); Region: DUF3703; pfam12487
983548005514	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
983548005515	MoxR-like ATPases [General function prediction only]; Region: COG0714
983548005516	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548005517	Walker A motif; other site
983548005518	ATP binding site [chemical binding]; other site
983548005519	Walker B motif; other site
983548005520	arginine finger; other site
983548005521	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
983548005522	Protein of unknown function DUF58; Region: DUF58; pfam01882
983548005523	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
983548005524	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
983548005525	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
983548005526	active site
983548005527	phosphorylation site [posttranslational modification]
983548005528	intermolecular recognition site; other site
983548005529	dimerization interface [polypeptide binding]; other site
983548005530	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548005531	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
983548005532	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548005533	ATP binding site [chemical binding]; other site
983548005534	Mg2+ binding site [ion binding]; other site
983548005535	G-X-G motif; other site
983548005536	FAD binding domain; Region: FAD_binding_4; pfam01565
983548005537	FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679
983548005538	D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030
983548005539	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
983548005540	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548005541	motif II; other site
983548005542	Saccharopine Dehydrogenase like proteins; Region: SDH_like; cd05199
983548005543	active site
983548005544	ligand binding site [chemical binding]; other site
983548005545	NAD(P) binding site [chemical binding]; other site
983548005546	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548005547	TIGR01777 family protein; Region: yfcH
983548005548	NAD(P) binding site [chemical binding]; other site
983548005549	active site
983548005550	YceI-like domain; Region: YceI; pfam04264
983548005551	GrpE; Region: GrpE; pfam01025
983548005552	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
983548005553	dimer interface [polypeptide binding]; other site
983548005554	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
983548005555	chaperone protein DnaJ; Provisional; Region: PRK14289
983548005556	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
983548005557	HSP70 interaction site [polypeptide binding]; other site
983548005558	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
983548005559	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
983548005560	dimer interface [polypeptide binding]; other site
983548005561	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
983548005562	ATP-binding cassette domain of an uncharacterized transporter; Region: ABC_putative_ATPase; cd03269
983548005563	Walker A/P-loop; other site
983548005564	ATP binding site [chemical binding]; other site
983548005565	Q-loop/lid; other site
983548005566	ABC transporter signature motif; other site
983548005567	Walker B; other site
983548005568	D-loop; other site
983548005569	H-loop/switch region; other site
983548005570	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
983548005571	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
983548005572	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548005573	Response regulator receiver domain; Region: Response_reg; pfam00072
983548005574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548005575	active site
983548005576	phosphorylation site [posttranslational modification]
983548005577	intermolecular recognition site; other site
983548005578	dimerization interface [polypeptide binding]; other site
983548005579	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548005580	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
983548005581	Walker A motif; other site
983548005582	ATP binding site [chemical binding]; other site
983548005583	Walker B motif; other site
983548005584	arginine finger; other site
983548005585	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
983548005586	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
983548005587	PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815
983548005588	PA/protease or protease-like domain interface [polypeptide binding]; other site
983548005589	M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883
983548005590	Peptidase family M28; Region: Peptidase_M28; pfam04389
983548005591	metal binding site [ion binding]; metal-binding site
983548005592	Domain of unknown function (DU1801); Region: DUF1801; cl17490
983548005593	multidrug efflux protein; Reviewed; Region: PRK01766
983548005594	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
983548005595	cation binding site [ion binding]; other site
983548005596	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
983548005597	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
983548005598	active site
983548005599	membrane ATPase/protein kinase; Provisional; Region: PRK09435
983548005600	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
983548005601	Walker A; other site
983548005602	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
983548005603	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548005604	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548005605	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548005606	DNA binding residues [nucleotide binding]
983548005607	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548005608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548005609	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
983548005610	active site
983548005611	motif I; other site
983548005612	motif II; other site
983548005613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548005614	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901
983548005615	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
983548005616	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
983548005617	nucleotide binding region [chemical binding]; other site
983548005618	ATP-binding site [chemical binding]; other site
983548005619	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
983548005620	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
983548005621	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
983548005622	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
983548005623	Walker A/P-loop; other site
983548005624	ATP binding site [chemical binding]; other site
983548005625	Q-loop/lid; other site
983548005626	ABC transporter signature motif; other site
983548005627	Walker B; other site
983548005628	D-loop; other site
983548005629	H-loop/switch region; other site
983548005630	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548005631	S-adenosylmethionine binding site [chemical binding]; other site
983548005632	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
983548005633	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548005634	Walker A/P-loop; other site
983548005635	ATP binding site [chemical binding]; other site
983548005636	Q-loop/lid; other site
983548005637	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548005638	ABC transporter signature motif; other site
983548005639	Walker B; other site
983548005640	ABC transporter; Region: ABC_tran_2; pfam12848
983548005641	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548005642	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
983548005643	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
983548005644	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
983548005645	Chain length determinant protein; Region: Wzz; cl15801
983548005646	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
983548005647	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
983548005648	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
983548005649	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
983548005650	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
983548005651	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
983548005652	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
983548005653	Walker A/P-loop; other site
983548005654	ATP binding site [chemical binding]; other site
983548005655	Q-loop/lid; other site
983548005656	ABC transporter signature motif; other site
983548005657	Walker B; other site
983548005658	D-loop; other site
983548005659	H-loop/switch region; other site
983548005660	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
983548005661	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
983548005662	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
983548005663	metal-binding site
983548005664	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005665	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005666	active site
983548005667	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005668	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005669	active site
983548005670	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
983548005671	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005672	active site
983548005673	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005674	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005675	active site
983548005676	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005677	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
983548005678	active site
983548005679	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
983548005680	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
983548005681	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005682	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548005683	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548005684	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005685	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
983548005686	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
983548005687	active site
983548005688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548005689	S-adenosylmethionine binding site [chemical binding]; other site
983548005690	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
983548005691	ligand binding site; other site
983548005692	tetramer interface; other site
983548005693	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
983548005694	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
983548005695	NeuB family; Region: NeuB; pfam03102
983548005696	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
983548005697	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
983548005698	Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171
983548005699	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005700	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
983548005701	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
983548005702	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
983548005703	active site
983548005704	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005705	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005706	active site
983548005707	putative acyl transferase; Provisional; Region: PRK10502
983548005708	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
983548005709	trimer interface [polypeptide binding]; other site
983548005710	active site
983548005711	substrate binding site [chemical binding]; other site
983548005712	CoA binding site [chemical binding]; other site
983548005713	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005714	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548005715	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005716	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548005717	O-Antigen ligase; Region: Wzy_C; pfam04932
983548005718	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
983548005719	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005720	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
983548005721	Bacterial sugar transferase; Region: Bac_transf; pfam02397
983548005722	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
983548005723	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
983548005724	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
983548005725	Phloem protein 2; Region: PP2; pfam14299
983548005726	CoA-ligase; Region: Ligase_CoA; pfam00549
983548005727	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
983548005728	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
983548005729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
983548005730	S-adenosylmethionine binding site [chemical binding]; other site
983548005731	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
983548005732	active site
983548005733	catalytic residues [active]
983548005734	triosephosphate isomerase; Provisional; Region: PRK14567
983548005735	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
983548005736	substrate binding site [chemical binding]; other site
983548005737	dimer interface [polypeptide binding]; other site
983548005738	catalytic triad [active]
983548005739	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
983548005740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
983548005741	dimer interface [polypeptide binding]; other site
983548005742	conserved gate region; other site
983548005743	putative PBP binding loops; other site
983548005744	ABC-ATPase subunit interface; other site
983548005745	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
983548005746	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
983548005747	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
983548005748	dihydropteroate synthase; Region: DHPS; TIGR01496
983548005749	substrate binding pocket [chemical binding]; other site
983548005750	dimer interface [polypeptide binding]; other site
983548005751	inhibitor binding site; inhibition site
983548005752	gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131
983548005753	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
983548005754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548005755	Walker A/P-loop; other site
983548005756	ATP binding site [chemical binding]; other site
983548005757	Q-loop/lid; other site
983548005758	ABC transporter signature motif; other site
983548005759	Walker B; other site
983548005760	D-loop; other site
983548005761	H-loop/switch region; other site
983548005762	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
983548005763	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005764	active site
983548005765	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
983548005766	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
983548005767	active site
983548005768	WxcM-like, C-terminal; Region: FdtA; pfam05523
983548005769	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005770	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
983548005771	putative ADP-binding pocket [chemical binding]; other site
983548005772	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548005773	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
983548005774	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
983548005775	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
983548005776	putative trimer interface [polypeptide binding]; other site
983548005777	putative CoA binding site [chemical binding]; other site
983548005778	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125
983548005779	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
983548005780	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
983548005781	inhibitor-cofactor binding pocket; inhibition site
983548005782	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548005783	catalytic residue [active]
983548005784	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
983548005785	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
983548005786	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
983548005787	G1 box; other site
983548005788	putative GEF interaction site [polypeptide binding]; other site
983548005789	GTP/Mg2+ binding site [chemical binding]; other site
983548005790	Switch I region; other site
983548005791	G2 box; other site
983548005792	G3 box; other site
983548005793	Switch II region; other site
983548005794	G4 box; other site
983548005795	G5 box; other site
983548005796	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
983548005797	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
983548005798	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
983548005799	active site
983548005800	multimer interface [polypeptide binding]; other site
983548005801	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
983548005802	DHH family; Region: DHH; pfam01368
983548005803	DHHA1 domain; Region: DHHA1; pfam02272
983548005804	peptidyl-prolyl isomerase, gliding motility-associated; Region: ppisom_GldI; TIGR03516
983548005805	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
983548005806	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
983548005807	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
983548005808	active site
983548005809	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
983548005810	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
983548005811	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
983548005812	metal binding site [ion binding]; metal-binding site
983548005813	dimer interface [polypeptide binding]; other site
983548005814	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
983548005815	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
983548005816	gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131
983548005817	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
983548005818	23S rRNA binding site [nucleotide binding]; other site
983548005819	L21 binding site [polypeptide binding]; other site
983548005820	L13 binding site [polypeptide binding]; other site
983548005821	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
983548005822	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
983548005823	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
983548005824	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
983548005825	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
983548005826	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
983548005827	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
983548005828	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
983548005829	active site
983548005830	dimer interface [polypeptide binding]; other site
983548005831	motif 1; other site
983548005832	motif 2; other site
983548005833	motif 3; other site
983548005834	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
983548005835	anticodon binding site; other site
983548005836	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
983548005837	generic binding surface I; other site
983548005838	generic binding surface II; other site
983548005839	Domain of unknown function (DUF4268); Region: DUF4268; pfam14088
983548005840	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
983548005841	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
983548005842	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
983548005843	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
983548005844	TRAM domain; Region: TRAM; pfam01938
983548005845	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
983548005846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548005847	S-adenosylmethionine binding site [chemical binding]; other site
983548005848	ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885
983548005849	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
983548005850	inhibitor-cofactor binding pocket; inhibition site
983548005851	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548005852	catalytic residue [active]
983548005853	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
983548005854	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548005855	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
983548005856	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
983548005857	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548005858	catalytic residue [active]
983548005859	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548005860	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548005861	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548005862	Peptidase family M23; Region: Peptidase_M23; pfam01551
983548005863	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
983548005864	Domain of unknown function (DUF4249); Region: DUF4249; pfam14054
983548005865	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548005866	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548005867	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548005868	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
983548005869	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
983548005870	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
983548005871	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
983548005872	prolyl-tRNA synthetase; Provisional; Region: PRK08661
983548005873	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
983548005874	dimer interface [polypeptide binding]; other site
983548005875	motif 1; other site
983548005876	active site
983548005877	motif 2; other site
983548005878	motif 3; other site
983548005879	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
983548005880	anticodon binding site; other site
983548005881	zinc-binding site [ion binding]; other site
983548005882	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
983548005883	Predicted flavoprotein [General function prediction only]; Region: COG0431
983548005884	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
983548005885	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
983548005886	active site
983548005887	catalytic site [active]
983548005888	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
983548005889	UbiA prenyltransferase family; Region: UbiA; pfam01040
983548005890	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
983548005891	IHF - DNA interface [nucleotide binding]; other site
983548005892	IHF dimer interface [polypeptide binding]; other site
983548005893	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
983548005894	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
983548005895	putative active site [active]
983548005896	substrate binding site [chemical binding]; other site
983548005897	putative cosubstrate binding site; other site
983548005898	catalytic site [active]
983548005899	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
983548005900	substrate binding site [chemical binding]; other site
983548005901	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
983548005902	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548005903	ATP binding site [chemical binding]; other site
983548005904	putative Mg++ binding site [ion binding]; other site
983548005905	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548005906	nucleotide binding region [chemical binding]; other site
983548005907	ATP-binding site [chemical binding]; other site
983548005908	Predicted ATPase [General function prediction only]; Region: COG3911
983548005909	AAA domain; Region: AAA_28; pfam13521
983548005910	Protein of unknown function (DUF493); Region: DUF493; pfam04359
983548005911	Domain of unknown function (DUF4290); Region: DUF4290; pfam14123
983548005912	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
983548005913	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
983548005914	hinge; other site
983548005915	active site
983548005916	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
983548005917	Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602
983548005918	putative active site [active]
983548005919	catalytic site [active]
983548005920	putative metal binding site [ion binding]; other site
983548005921	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
983548005922	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
983548005923	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
983548005924	FeS/SAM binding site; other site
983548005925	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
983548005926	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
983548005927	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
983548005928	CoenzymeA binding site [chemical binding]; other site
983548005929	subunit interaction site [polypeptide binding]; other site
983548005930	PHB binding site; other site
983548005931	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
983548005932	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
983548005933	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
983548005934	dimer interface [polypeptide binding]; other site
983548005935	tetramer interface [polypeptide binding]; other site
983548005936	PYR/PP interface [polypeptide binding]; other site
983548005937	TPP binding site [chemical binding]; other site
983548005938	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
983548005939	TPP-binding site; other site
983548005940	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
983548005941	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
983548005942	S1 domain; Region: S1_2; pfam13509
983548005943	S1 domain; Region: S1_2; pfam13509
983548005944	Peptidase C1-like family; Region: Peptidase_C1_2; cl17447
983548005945	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
983548005946	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
983548005947	substrate binding site [chemical binding]; other site
983548005948	oxyanion hole (OAH) forming residues; other site
983548005949	trimer interface [polypeptide binding]; other site
983548005950	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
983548005951	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
983548005952	oligomer interface [polypeptide binding]; other site
983548005953	active site
983548005954	metal binding site [ion binding]; metal-binding site
983548005955	Domain of unknown function (DUF4294); Region: DUF4294; pfam14127
983548005956	DinB superfamily; Region: DinB_2; pfam12867
983548005957	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
983548005958	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
983548005959	putative active site [active]
983548005960	Regulator of replication initiation timing [Replication,    recombination, and repair]; Region: COG4467; cl01853
983548005961	Cell division protein ZapA; Region: ZapA; pfam05164
983548005962	phosphodiesterase; Provisional; Region: PRK12704
983548005963	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548005964	Zn2+ binding site [ion binding]; other site
983548005965	Mg2+ binding site [ion binding]; other site
983548005966	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548005967	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
983548005968	Coenzyme A binding pocket [chemical binding]; other site
983548005969	argininosuccinate synthase; Provisional; Region: PRK13820
983548005970	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
983548005971	Ligand Binding Site [chemical binding]; other site
983548005972	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
983548005973	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
983548005974	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
983548005975	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
983548005976	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
983548005977	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
983548005978	inhibitor-cofactor binding pocket; inhibition site
983548005979	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548005980	catalytic residue [active]
983548005981	N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523
983548005982	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
983548005983	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
983548005984	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
983548005985	nucleotide binding site [chemical binding]; other site
983548005986	N-acetyl-L-glutamate binding site [chemical binding]; other site
983548005987	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
983548005988	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651
983548005989	metal binding site [ion binding]; metal-binding site
983548005990	dimer interface [polypeptide binding]; other site
983548005991	Lyase; Region: Lyase_1; pfam00206
983548005992	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
983548005993	active sites [active]
983548005994	tetramer interface [polypeptide binding]; other site
983548005995	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
983548005996	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
983548005997	tartrate dehydrogenase; Region: TTC; TIGR02089
983548005998	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
983548005999	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
983548006000	substrate binding site [chemical binding]; other site
983548006001	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
983548006002	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
983548006003	substrate binding site [chemical binding]; other site
983548006004	ligand binding site [chemical binding]; other site
983548006005	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
983548006006	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
983548006007	active site
983548006008	catalytic residues [active]
983548006009	metal binding site [ion binding]; metal-binding site
983548006010	EamA-like transporter family; Region: EamA; pfam00892
983548006011	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
983548006012	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
983548006013	active site
983548006014	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
983548006015	oligomerization interface [polypeptide binding]; other site
983548006016	active site
983548006017	metal binding site [ion binding]; metal-binding site
983548006018	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
983548006019	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
983548006020	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
983548006021	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
983548006022	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548006023	Coenzyme A binding pocket [chemical binding]; other site
983548006024	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
983548006025	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
983548006026	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
983548006027	14-3-3 domain; Region: 14-3-3; cl02098
983548006028	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548006029	Amidohydrolase; Region: Amidohydro_4; pfam13147
983548006030	active site
983548006031	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
983548006032	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
983548006033	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
983548006034	putative dimer interface [polypeptide binding]; other site
983548006035	excinuclease ABC subunit B; Provisional; Region: PRK05298
983548006036	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548006037	ATP binding site [chemical binding]; other site
983548006038	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548006039	nucleotide binding region [chemical binding]; other site
983548006040	ATP-binding site [chemical binding]; other site
983548006041	Ultra-violet resistance protein B; Region: UvrB; pfam12344
983548006042	UvrB/uvrC motif; Region: UVR; pfam02151
983548006043	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
983548006044	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
983548006045	inhibitor-cofactor binding pocket; inhibition site
983548006046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548006047	catalytic residue [active]
983548006048	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
983548006049	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
983548006050	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
983548006051	ATP-grasp domain; Region: ATP-grasp_4; cl17255
983548006052	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
983548006053	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
983548006054	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
983548006055	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
983548006056	ATP-grasp domain; Region: ATP-grasp_4; cl17255
983548006057	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548006058	DNA recombination protein RmuC; Provisional; Region: PRK10361
983548006059	RmuC family; Region: RmuC; pfam02646
983548006060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
983548006061	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
983548006062	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
983548006063	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
983548006064	Walker A/P-loop; other site
983548006065	ATP binding site [chemical binding]; other site
983548006066	Q-loop/lid; other site
983548006067	ABC transporter signature motif; other site
983548006068	Walker B; other site
983548006069	D-loop; other site
983548006070	H-loop/switch region; other site
983548006071	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
983548006072	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
983548006073	ABC-ATPase subunit  interface; other site
983548006074	dimer interface [polypeptide binding]; other site
983548006075	putative PBP binding regions; other site
983548006076	Periplasmic binding protein TroA_d.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_d; cd01141
983548006077	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
983548006078	putative ligand binding site [chemical binding]; other site
983548006079	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548006080	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
983548006081	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
983548006082	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
983548006083	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
983548006084	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
983548006085	protein binding site [polypeptide binding]; other site
983548006086	C-terminal processing peptidase-like; serine protease family S41; Region: Peptidase_S41_CPP_like; cd07561
983548006087	Catalytic dyad [active]
983548006088	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548006089	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
983548006090	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548006091	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
983548006092	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
983548006093	FtsX-like permease family; Region: FtsX; pfam02687
983548006094	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
983548006095	Peptidase family M1; Region: Peptidase_M1; pfam01433
983548006096	Zn binding site [ion binding]; other site
983548006097	DsrE/DsrF-like family; Region: DrsE; pfam02635
983548006098	beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753
983548006099	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021
983548006100	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; pfam01036
983548006101	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
983548006102	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
983548006103	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
983548006104	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
983548006105	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
983548006106	Transcription termination factor [Transcription]; Region: Rho; COG1158
983548006107	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
983548006108	RNA binding site [nucleotide binding]; other site
983548006109	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
983548006110	multimer interface [polypeptide binding]; other site
983548006111	Walker A motif; other site
983548006112	ATP binding site [chemical binding]; other site
983548006113	Walker B motif; other site
983548006114	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
983548006115	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
983548006116	Sulfate transporter family; Region: Sulfate_transp; pfam00916
983548006117	Sulfate transporter family; Region: Sulfate_transp; pfam00916
983548006118	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
983548006119	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
983548006120	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
983548006121	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
983548006122	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548006123	ligand binding site [chemical binding]; other site
983548006124	flexible hinge region; other site
983548006125	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
983548006126	non-specific DNA interactions [nucleotide binding]; other site
983548006127	DNA binding site [nucleotide binding]
983548006128	sequence specific DNA binding site [nucleotide binding]; other site
983548006129	putative cAMP binding site [chemical binding]; other site
983548006130	Histidine kinase; Region: His_kinase; pfam06580
983548006131	2TM domain; Region: 2TM; pfam13239
983548006132	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
983548006133	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548006134	non-specific DNA binding site [nucleotide binding]; other site
983548006135	salt bridge; other site
983548006136	sequence-specific DNA binding site [nucleotide binding]; other site
983548006137	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239
983548006138	putative active site [active]
983548006139	Zn binding site [ion binding]; other site
983548006140	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
983548006141	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
983548006142	putative DNA binding site [nucleotide binding]; other site
983548006143	putative Zn2+ binding site [ion binding]; other site
983548006144	AsnC family; Region: AsnC_trans_reg; pfam01037
983548006145	DinB superfamily; Region: DinB_2; pfam12867
983548006146	metal-dependent hydrolase; Provisional; Region: PRK13291
983548006147	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
983548006148	active site
983548006149	dimer interface [polypeptide binding]; other site
983548006150	metal binding site [ion binding]; metal-binding site
983548006151	Proline dehydrogenase; Region: Pro_dh; cl03282
983548006152	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
983548006153	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
983548006154	active site
983548006155	catalytic triad [active]
983548006156	oxyanion hole [active]
983548006157	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
983548006158	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
983548006159	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
983548006160	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548006161	TPR repeat; Region: TPR_11; pfam13414
983548006162	binding surface
983548006163	TPR motif; other site
983548006164	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
983548006165	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
983548006166	putative active site [active]
983548006167	putative NTP binding site [chemical binding]; other site
983548006168	putative nucleic acid binding site [nucleotide binding]; other site
983548006169	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
983548006170	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
983548006171	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
983548006172	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
983548006173	putative active site [active]
983548006174	putative NTP binding site [chemical binding]; other site
983548006175	putative nucleic acid binding site [nucleotide binding]; other site
983548006176	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
983548006177	HNH endonuclease; Region: HNH_3; pfam13392
983548006178	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
983548006179	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
983548006180	active site
983548006181	DNA binding site [nucleotide binding]
983548006182	Int/Topo IB signature motif; other site
983548006183	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
983548006184	Protein of unknown function (DUF819); Region: DUF819; cl02317
983548006185	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
983548006186	putative ligand binding site [chemical binding]; other site
983548006187	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
983548006188	M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299
983548006189	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
983548006190	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548006191	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
983548006192	active site
983548006193	Zn binding site [ion binding]; other site
983548006194	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
983548006195	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
983548006196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
983548006197	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
983548006198	Predicted membrane protein [Function unknown]; Region: COG4270
983548006199	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548006200	NAD(P) binding site [chemical binding]; other site
983548006201	active site
983548006202	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
983548006203	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
983548006204	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
983548006205	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
983548006206	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548006207	catalytic residue [active]
983548006208	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548006209	non-specific DNA binding site [nucleotide binding]; other site
983548006210	salt bridge; other site
983548006211	sequence-specific DNA binding site [nucleotide binding]; other site
983548006212	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
983548006213	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
983548006214	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
983548006215	active site
983548006216	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
983548006217	putative active site [active]
983548006218	putative CoA binding site [chemical binding]; other site
983548006219	nudix motif; other site
983548006220	metal binding site [ion binding]; metal-binding site
983548006221	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
983548006222	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
983548006223	putative acyl-acceptor binding pocket; other site
983548006224	Phosphopantetheine attachment site; Region: PP-binding; cl09936
983548006225	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548006226	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548006227	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548006228	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548006229	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
983548006230	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
983548006231	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
983548006232	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
983548006233	dimerization interface [polypeptide binding]; other site
983548006234	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
983548006235	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
983548006236	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
983548006237	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494
983548006238	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
983548006239	Na binding site [ion binding]; other site
983548006240	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
983548006241	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548006242	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
983548006243	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
983548006244	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
983548006245	oligomer interface [polypeptide binding]; other site
983548006246	metal binding site [ion binding]; metal-binding site
983548006247	metal binding site [ion binding]; metal-binding site
983548006248	Cl binding site [ion binding]; other site
983548006249	aspartate ring; other site
983548006250	basic sphincter; other site
983548006251	putative hydrophobic gate; other site
983548006252	periplasmic entrance; other site
983548006253	Maf-like protein; Region: Maf; pfam02545
983548006254	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
983548006255	active site
983548006256	dimer interface [polypeptide binding]; other site
983548006257	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
983548006258	UbiA prenyltransferase family; Region: UbiA; pfam01040
983548006259	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
983548006260	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548006261	active site
983548006262	motif I; other site
983548006263	motif II; other site
983548006264	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
983548006265	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
983548006266	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
983548006267	7TMR-DISM extracellular 2; Region: 7TMR-DISMED2; pfam07696
983548006268	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
983548006269	fumarate hydratase; Reviewed; Region: fumC; PRK00485
983548006270	Class II fumarases; Region: Fumarase_classII; cd01362
983548006271	active site
983548006272	tetramer interface [polypeptide binding]; other site
983548006273	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
983548006274	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
983548006275	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
983548006276	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
983548006277	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
983548006278	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
983548006279	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
983548006280	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
983548006281	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
983548006282	GTP-binding protein YchF; Reviewed; Region: PRK09601
983548006283	YchF GTPase; Region: YchF; cd01900
983548006284	G1 box; other site
983548006285	GTP/Mg2+ binding site [chemical binding]; other site
983548006286	Switch I region; other site
983548006287	G2 box; other site
983548006288	Switch II region; other site
983548006289	G3 box; other site
983548006290	G4 box; other site
983548006291	G5 box; other site
983548006292	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
983548006293	Sensors of blue-light using FAD; Region: BLUF; pfam04940
983548006294	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
983548006295	MarR family; Region: MarR_2; cl17246
983548006296	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
983548006297	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
983548006298	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548006299	ATP binding site [chemical binding]; other site
983548006300	putative Mg++ binding site [ion binding]; other site
983548006301	Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576
983548006302	Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787
983548006303	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
983548006304	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
983548006305	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
983548006306	type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497
983548006307	HsdM N-terminal domain; Region: HsdM_N; pfam12161
983548006308	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548006309	S-adenosylmethionine binding site [chemical binding]; other site
983548006310	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548006311	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548006312	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548006313	ligand binding site [chemical binding]; other site
983548006314	Protein of unknown function (DUF3308); Region: DUF3308; pfam11751
983548006315	Domain of unknown function DUF11; Region: DUF11; pfam01345
983548006316	C-terminal domain of CHU protein family; Region: CHU_C; pfam13585
983548006317	Protein of unknown function (DUF3037); Region: DUF3037; pfam11236
983548006318	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
983548006319	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
983548006320	glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562
983548006321	transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932
983548006322	TrkA-N domain; Region: TrkA_N; pfam02254
983548006323	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
983548006324	Family description; Region: UvrD_C_2; pfam13538
983548006325	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
983548006326	active site
983548006327	catalytic site [active]
983548006328	substrate binding site [chemical binding]; other site
983548006329	nucleotide excision repair endonuclease; Provisional; Region: PRK10545
983548006330	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
983548006331	GIY-YIG motif/motif A; other site
983548006332	active site
983548006333	catalytic site [active]
983548006334	putative DNA binding site [nucleotide binding]; other site
983548006335	metal binding site [ion binding]; metal-binding site
983548006336	Domain of unknown function (DUF2383); Region: DUF2383; pfam09537
983548006337	Sensors of blue-light using FAD; Region: BLUF; cl04855
983548006338	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
983548006339	dimer interface [polypeptide binding]; other site
983548006340	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548006341	Predicted membrane protein [Function unknown]; Region: COG2323
983548006342	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006343	Ligand Binding Site [chemical binding]; other site
983548006344	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
983548006345	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
983548006346	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
983548006347	active site
983548006348	nucleophile elbow; other site
983548006349	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548006350	active site
983548006351	Sigma 54 modulation protein / S30EA ribosomal protein; Region: Ribosomal_S30AE; pfam02482
983548006352	30S subunit binding site; other site
983548006353	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006354	Ligand Binding Site [chemical binding]; other site
983548006355	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006356	Ligand Binding Site [chemical binding]; other site
983548006357	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
983548006358	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
983548006359	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548006360	Protein of unknown function (DUF664); Region: DUF664; pfam04978
983548006361	DinB superfamily; Region: DinB_2; pfam12867
983548006362	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
983548006363	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
983548006364	chaperone protein DnaJ; Provisional; Region: PRK14299
983548006365	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
983548006366	HSP70 interaction site [polypeptide binding]; other site
983548006367	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
983548006368	substrate binding site [polypeptide binding]; other site
983548006369	dimer interface [polypeptide binding]; other site
983548006370	PAS domain S-box; Region: sensory_box; TIGR00229
983548006371	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006372	putative active site [active]
983548006373	heme pocket [chemical binding]; other site
983548006374	PAS domain S-box; Region: sensory_box; TIGR00229
983548006375	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006376	putative active site [active]
983548006377	heme pocket [chemical binding]; other site
983548006378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548006379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548006380	dimer interface [polypeptide binding]; other site
983548006381	phosphorylation site [posttranslational modification]
983548006382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548006383	ATP binding site [chemical binding]; other site
983548006384	Mg2+ binding site [ion binding]; other site
983548006385	G-X-G motif; other site
983548006386	Response regulator receiver domain; Region: Response_reg; pfam00072
983548006387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548006388	active site
983548006389	phosphorylation site [posttranslational modification]
983548006390	intermolecular recognition site; other site
983548006391	dimerization interface [polypeptide binding]; other site
983548006392	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
983548006393	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548006394	ligand binding site [chemical binding]; other site
983548006395	flexible hinge region; other site
983548006396	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
983548006397	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006398	Ligand Binding Site [chemical binding]; other site
983548006399	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006400	Ligand Binding Site [chemical binding]; other site
983548006401	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006402	Ligand Binding Site [chemical binding]; other site
983548006403	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006404	Ligand Binding Site [chemical binding]; other site
983548006405	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006406	Ligand Binding Site [chemical binding]; other site
983548006407	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006408	Ligand Binding Site [chemical binding]; other site
983548006409	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006410	Ligand Binding Site [chemical binding]; other site
983548006411	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006412	Ligand Binding Site [chemical binding]; other site
983548006413	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006414	Ligand Binding Site [chemical binding]; other site
983548006415	ATP cone domain; Region: ATP-cone; pfam03477
983548006416	Restriction endonuclease; Region: Mrr_cat; pfam04471
983548006417	FOG: CBS domain [General function prediction only]; Region: COG0517
983548006418	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
983548006419	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
983548006420	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
983548006421	Heavy-metal-associated domain; Region: HMA; pfam00403
983548006422	metal-binding site [ion binding]
983548006423	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
983548006424	Soluble P-type ATPase [General function prediction only]; Region: COG4087
983548006425	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
983548006426	putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485
983548006427	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
983548006428	Low-spin heme binding site [chemical binding]; other site
983548006429	Putative water exit pathway; other site
983548006430	Binuclear center (active site) [active]
983548006431	Putative proton exit pathway; other site
983548006432	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
983548006433	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
983548006434	Cytochrome c; Region: Cytochrom_C; pfam00034
983548006435	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
983548006436	4Fe-4S binding domain; Region: Fer4_5; pfam12801
983548006437	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
983548006438	FixH; Region: FixH; pfam05751
983548006439	Family description; Region: DsbD_2; pfam13386
983548006440	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
983548006441	HemN C-terminal domain; Region: HemN_C; pfam06969
983548006442	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
983548006443	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548006444	active site
983548006445	phosphorylation site [posttranslational modification]
983548006446	intermolecular recognition site; other site
983548006447	dimerization interface [polypeptide binding]; other site
983548006448	Heme NO binding; Region: HNOB; pfam07700
983548006449	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
983548006450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006451	putative active site [active]
983548006452	heme pocket [chemical binding]; other site
983548006453	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
983548006454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006455	putative active site [active]
983548006456	heme pocket [chemical binding]; other site
983548006457	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548006458	dimer interface [polypeptide binding]; other site
983548006459	phosphorylation site [posttranslational modification]
983548006460	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548006461	ATP binding site [chemical binding]; other site
983548006462	Mg2+ binding site [ion binding]; other site
983548006463	G-X-G motif; other site
983548006464	Uncharacterized conserved protein [Function unknown]; Region: COG3287
983548006465	FIST N domain; Region: FIST; pfam08495
983548006466	FIST C domain; Region: FIST_C; pfam10442
983548006467	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548006468	dimer interface [polypeptide binding]; other site
983548006469	phosphorylation site [posttranslational modification]
983548006470	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548006471	ATP binding site [chemical binding]; other site
983548006472	Mg2+ binding site [ion binding]; other site
983548006473	G-X-G motif; other site
983548006474	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
983548006475	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
983548006476	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548006477	active site
983548006478	phosphorylation site [posttranslational modification]
983548006479	intermolecular recognition site; other site
983548006480	dimerization interface [polypeptide binding]; other site
983548006481	LytTr DNA-binding domain; Region: LytTR; smart00850
983548006482	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548006483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548006484	TPR motif; other site
983548006485	binding surface
983548006486	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548006487	binding surface
983548006488	TPR repeat; Region: TPR_11; pfam13414
983548006489	TPR motif; other site
983548006490	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
983548006491	Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038
983548006492	putative active site [active]
983548006493	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
983548006494	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548006495	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548006496	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
983548006497	Predicted integral membrane protein [Function unknown]; Region: COG5617
983548006498	DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188
983548006499	Ligand binding site; other site
983548006500	Ligand binding site; other site
983548006501	Ligand binding site; other site
983548006502	Putative Catalytic site; other site
983548006503	DXD motif; other site
983548006504	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
983548006505	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
983548006506	YHYH protein; Region: YHYH; pfam14240
983548006507	EF-hand domain pair; Region: EF_hand_5; pfam13499
983548006508	pseudo EF-hand loop; other site
983548006509	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
983548006510	peptide binding pocket; other site
983548006511	Ca2+ binding site [ion binding]; other site
983548006512	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
983548006513	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
983548006514	Cu(I) binding site [ion binding]; other site
983548006515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849
983548006516	YHYH protein; Region: YHYH; pfam14240
983548006517	Histidine kinase; Region: His_kinase; pfam06580
983548006518	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
983548006519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548006520	active site
983548006521	phosphorylation site [posttranslational modification]
983548006522	intermolecular recognition site; other site
983548006523	dimerization interface [polypeptide binding]; other site
983548006524	LytTr DNA-binding domain; Region: LytTR; smart00850
983548006525	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
983548006526	FMN binding site [chemical binding]; other site
983548006527	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
983548006528	substrate binding site [chemical binding]; other site
983548006529	putative catalytic residue [active]
983548006530	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
983548006531	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
983548006532	active site
983548006533	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
983548006534	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
983548006535	active site
983548006536	Acyl transferase domain; Region: Acyl_transf_1; cl08282
983548006537	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
983548006538	dimer interface [polypeptide binding]; other site
983548006539	active site 1 [active]
983548006540	active site 2 [active]
983548006541	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
983548006542	dimer interface [polypeptide binding]; other site
983548006543	active site 1 [active]
983548006544	active site 2 [active]
983548006545	potential frameshift: common BLAST hit: gi|298492699|ref|YP_003722876.1| polyketide-type polyunsaturated fatty acid synthase PfaA
983548006546	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
983548006547	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
983548006548	putative NADP binding site [chemical binding]; other site
983548006549	active site
983548006550	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
983548006551	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
983548006552	active site
983548006553	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
983548006554	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
983548006555	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
983548006556	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
983548006557	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
983548006558	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
983548006559	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
983548006560	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
983548006561	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
983548006562	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
983548006563	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
983548006564	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548006565	active site
983548006566	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548006567	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
983548006568	FecR protein; Region: FecR; pfam04773
983548006569	RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985
983548006570	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548006571	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548006572	DNA binding residues [nucleotide binding]
983548006573	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548006574	fumarylacetoacetase; Region: PLN02856
983548006575	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
983548006576	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
983548006577	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
983548006578	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
983548006579	dimer interface [polypeptide binding]; other site
983548006580	active site
983548006581	glycine-pyridoxal phosphate binding site [chemical binding]; other site
983548006582	folate binding site [chemical binding]; other site
983548006583	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
983548006584	metal binding site [ion binding]; metal-binding site
983548006585	periplasmic chaperone; Provisional; Region: PRK10780
983548006586	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
983548006587	SurA N-terminal domain; Region: SurA_N_3; cl07813
983548006588	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
983548006589	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
983548006590	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
983548006591	SurA N-terminal domain; Region: SurA_N; pfam09312
983548006592	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
983548006593	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
983548006594	MoxR-like ATPases [General function prediction only]; Region: COG0714
983548006595	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548006596	Walker A motif; other site
983548006597	ATP binding site [chemical binding]; other site
983548006598	Walker B motif; other site
983548006599	arginine finger; other site
983548006600	aconitate hydratase; Validated; Region: PRK07229
983548006601	Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285
983548006602	substrate binding site [chemical binding]; other site
983548006603	ligand binding site [chemical binding]; other site
983548006604	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
983548006605	substrate binding site [chemical binding]; other site
983548006606	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548006607	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
983548006608	active site
983548006609	metal binding site [ion binding]; metal-binding site
983548006610	Predicted transcriptional regulators [Transcription]; Region: COG1733
983548006611	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
983548006612	PAS fold; Region: PAS_3; pfam08447
983548006613	PAS fold; Region: PAS_3; pfam08447
983548006614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006615	putative active site [active]
983548006616	heme pocket [chemical binding]; other site
983548006617	PAS fold; Region: PAS_4; pfam08448
983548006618	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006619	putative active site [active]
983548006620	heme pocket [chemical binding]; other site
983548006621	PAS domain; Region: PAS_9; pfam13426
983548006622	PAS fold; Region: PAS_3; pfam08447
983548006623	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548006624	heme pocket [chemical binding]; other site
983548006625	putative active site [active]
983548006626	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548006627	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548006628	dimer interface [polypeptide binding]; other site
983548006629	phosphorylation site [posttranslational modification]
983548006630	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548006631	ATP binding site [chemical binding]; other site
983548006632	Mg2+ binding site [ion binding]; other site
983548006633	G-X-G motif; other site
983548006634	Response regulator receiver domain; Region: Response_reg; pfam00072
983548006635	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548006636	active site
983548006637	phosphorylation site [posttranslational modification]
983548006638	intermolecular recognition site; other site
983548006639	dimerization interface [polypeptide binding]; other site
983548006640	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548006641	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
983548006642	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
983548006643	N-terminal plug; other site
983548006644	ligand-binding site [chemical binding]; other site
983548006645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548006646	binding surface
983548006647	TPR motif; other site
983548006648	TPR repeat; Region: TPR_11; pfam13414
983548006649	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
983548006650	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
983548006651	active site
983548006652	FMN binding site [chemical binding]; other site
983548006653	substrate binding site [chemical binding]; other site
983548006654	3Fe-4S cluster binding site [ion binding]; other site
983548006655	Protein of unknown function (DUF3810); Region: DUF3810; pfam12725
983548006656	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548006657	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548006658	Amidohydrolase; Region: Amidohydro_4; pfam13147
983548006659	active site
983548006660	Urease alpha-subunit, N-terminal domain; Region: Urease_alpha; pfam00449
983548006661	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
983548006662	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
983548006663	active site
983548006664	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548006665	Amidohydrolase; Region: Amidohydro_4; pfam13147
983548006666	active site
983548006667	homoserine kinase; Provisional; Region: PRK01212
983548006668	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
983548006669	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
983548006670	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
983548006671	AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243
983548006672	putative catalytic residues [active]
983548006673	nucleotide binding site [chemical binding]; other site
983548006674	aspartate binding site [chemical binding]; other site
983548006675	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
983548006676	dimer interface [polypeptide binding]; other site
983548006677	putative threonine allosteric regulatory site; other site
983548006678	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
983548006679	putative threonine allosteric regulatory site; other site
983548006680	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
983548006681	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
983548006682	putative carbohydrate kinase; Provisional; Region: PRK10565
983548006683	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
983548006684	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
983548006685	putative substrate binding site [chemical binding]; other site
983548006686	putative ATP binding site [chemical binding]; other site
983548006687	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548006688	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
983548006689	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548006690	Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078
983548006691	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
983548006692	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
983548006693	putative ligand binding site [chemical binding]; other site
983548006694	NAD binding site [chemical binding]; other site
983548006695	dimerization interface [polypeptide binding]; other site
983548006696	catalytic site [active]
983548006697	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
983548006698	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548006699	catalytic residue [active]
983548006700	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
983548006701	NAD(P) binding site [chemical binding]; other site
983548006702	4Fe-4S binding domain; Region: Fer4; cl02805
983548006703	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
983548006704	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
983548006705	Sulfate transporter family; Region: Sulfate_transp; pfam00916
983548006706	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
983548006707	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
983548006708	Ligand Binding Site [chemical binding]; other site
983548006709	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
983548006710	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
983548006711	ArsC family; Region: ArsC; pfam03960
983548006712	catalytic residues [active]
983548006713	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
983548006714	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548006715	motif II; other site
983548006716	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
983548006717	DJ-1 family protein; Region: not_thiJ; TIGR01383
983548006718	conserved cys residue [active]
983548006719	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548006720	Major Facilitator Superfamily; Region: MFS_1; pfam07690
983548006721	putative substrate translocation pore; other site
983548006722	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_1; cd06238
983548006723	putative active site [active]
983548006724	Zn binding site [ion binding]; other site
983548006725	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
983548006726	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
983548006727	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
983548006728	nucleotide binding site [chemical binding]; other site
983548006729	Domain of unknown function DUF20; Region: UPF0118; pfam01594
983548006730	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
983548006731	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
983548006732	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548006733	putative metal binding site [ion binding]; other site
983548006734	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
983548006735	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
983548006736	substrate binding site [chemical binding]; other site
983548006737	glutamase interaction surface [polypeptide binding]; other site
983548006738	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
983548006739	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
983548006740	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
983548006741	metal binding site [ion binding]; metal-binding site
983548006742	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
983548006743	Active site serine [active]
983548006744	LytTr DNA-binding domain; Region: LytTR; smart00850
983548006745	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
983548006746	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
983548006747	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
983548006748	active site
983548006749	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
983548006750	intracellular protease, PfpI family; Region: PfpI; TIGR01382
983548006751	proposed catalytic triad [active]
983548006752	conserved cys residue [active]
983548006753	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
983548006754	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
983548006755	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548006756	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548006757	ligand binding site [chemical binding]; other site
983548006758	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
983548006759	putative FMN binding site [chemical binding]; other site
983548006760	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
983548006761	30S subunit binding site; other site
983548006762	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
983548006763	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548006764	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
983548006765	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
983548006766	NAD(P) binding site [chemical binding]; other site
983548006767	catalytic residues [active]
983548006768	Protein of unknown function DUF72; Region: DUF72; pfam01904
983548006769	AAA domain; Region: AAA_33; pfam13671
983548006770	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
983548006771	ATP-binding site [chemical binding]; other site
983548006772	Gluconate-6-phosphate binding site [chemical binding]; other site
983548006773	fructuronate transporter; Provisional; Region: PRK10034; cl15264
983548006774	GntP family permease; Region: GntP_permease; pfam02447
983548006775	adenylosuccinate lyase; Provisional; Region: PRK09285
983548006776	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
983548006777	tetramer interface [polypeptide binding]; other site
983548006778	active site
983548006779	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
983548006780	Protein of unknown function DUF58; Region: DUF58; pfam01882
983548006781	MoxR-like ATPases [General function prediction only]; Region: COG0714
983548006782	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548006783	Walker A motif; other site
983548006784	ATP binding site [chemical binding]; other site
983548006785	Walker B motif; other site
983548006786	arginine finger; other site
983548006787	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
983548006788	Integral membrane protein DUF95; Region: DUF95; pfam01944
983548006789	RDD family; Region: RDD; pfam06271
983548006790	Predicted membrane protein [Function unknown]; Region: COG2860
983548006791	UPF0126 domain; Region: UPF0126; pfam03458
983548006792	UPF0126 domain; Region: UPF0126; pfam03458
983548006793	CoA binding domain; Region: CoA_binding_2; pfam13380
983548006794	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
983548006795	Na binding site [ion binding]; other site
983548006796	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
983548006797	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
983548006798	FtsX-like permease family; Region: FtsX; pfam02687
983548006799	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
983548006800	motif 1; other site
983548006801	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
983548006802	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
983548006803	active site
983548006804	dimer interface [polypeptide binding]; other site
983548006805	motif 2; other site
983548006806	motif 3; other site
983548006807	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
983548006808	anticodon binding site; other site
983548006809	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
983548006810	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
983548006811	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
983548006812	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
983548006813	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
983548006814	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
983548006815	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548006816	TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715
983548006817	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
983548006818	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
983548006819	MutS domain III; Region: MutS_III; pfam05192
983548006820	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548006821	Walker A/P-loop; other site
983548006822	ATP binding site [chemical binding]; other site
983548006823	Q-loop/lid; other site
983548006824	ABC transporter signature motif; other site
983548006825	Walker B; other site
983548006826	D-loop; other site
983548006827	H-loop/switch region; other site
983548006828	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
983548006829	ligand binding site [chemical binding]; other site
983548006830	active site
983548006831	UGI interface [polypeptide binding]; other site
983548006832	catalytic site [active]
983548006833	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
983548006834	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
983548006835	polyphosphate kinase; Provisional; Region: PRK05443
983548006836	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
983548006837	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
983548006838	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
983548006839	domain interface [polypeptide binding]; other site
983548006840	active site
983548006841	catalytic site [active]
983548006842	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
983548006843	domain interface [polypeptide binding]; other site
983548006844	active site
983548006845	catalytic site [active]
983548006846	uridine phosphorylase; Provisional; Region: PRK11178
983548006847	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
983548006848	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
983548006849	putative rRNA binding site [nucleotide binding]; other site
983548006850	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
983548006851	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
983548006852	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
983548006853	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
983548006854	NADH(P)-binding; Region: NAD_binding_10; pfam13460
983548006855	NAD(P) binding site [chemical binding]; other site
983548006856	putative active site [active]
983548006857	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
983548006858	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
983548006859	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
983548006860	Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890
983548006861	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548006862	S-adenosylmethionine binding site [chemical binding]; other site
983548006863	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
983548006864	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
983548006865	tetramer interface [polypeptide binding]; other site
983548006866	TPP-binding site [chemical binding]; other site
983548006867	heterodimer interface [polypeptide binding]; other site
983548006868	phosphorylation loop region [posttranslational modification]
983548006869	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
983548006870	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
983548006871	alpha subunit interface [polypeptide binding]; other site
983548006872	TPP binding site [chemical binding]; other site
983548006873	heterodimer interface [polypeptide binding]; other site
983548006874	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
983548006875	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548006876	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548006877	ligand binding site [chemical binding]; other site
983548006878	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
983548006879	Methyltransferase domain; Region: Methyltransf_31; pfam13847
983548006880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548006881	S-adenosylmethionine binding site [chemical binding]; other site
983548006882	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
983548006883	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
983548006884	malonyl-CoA binding site [chemical binding]; other site
983548006885	dimer interface [polypeptide binding]; other site
983548006886	active site
983548006887	product binding site; other site
983548006888	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063
983548006889	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548006890	NAD(P) binding site [chemical binding]; other site
983548006891	active site
983548006892	FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493
983548006893	active site 2 [active]
983548006894	dimer interface [polypeptide binding]; other site
983548006895	active site 1 [active]
983548006896	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
983548006897	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
983548006898	dimer interface [polypeptide binding]; other site
983548006899	active site
983548006900	Phosphopantetheine attachment site; Region: PP-binding; cl09936
983548006901	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
983548006902	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548006903	ATP binding site [chemical binding]; other site
983548006904	Mg2+ binding site [ion binding]; other site
983548006905	G-X-G motif; other site
983548006906	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783
983548006907	ATP binding site [chemical binding]; other site
983548006908	TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands...; Region: TOPRIM_TopoIIA_like; cd01030
983548006909	active site
983548006910	putative metal-binding site [ion binding]; other site
983548006911	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
983548006912	DNA topoisomerase IV subunit A; Provisional; Region: PRK12758
983548006913	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cl00148
983548006914	CAP-like domain; other site
983548006915	active site
983548006916	primary dimer interface [polypeptide binding]; other site
983548006917	Bacterial Ig-like domain; Region: Big_5; pfam13205
983548006918	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
983548006919	Interdomain contacts; other site
983548006920	Cytokine receptor motif; other site
983548006921	gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131
983548006922	gliding motility-associated C-terminal domain; Region: Bac_Flav_CTERM; TIGR04131
983548006923	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
983548006924	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
983548006925	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
983548006926	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
983548006927	Response regulator receiver domain; Region: Response_reg; pfam00072
983548006928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548006929	active site
983548006930	phosphorylation site [posttranslational modification]
983548006931	intermolecular recognition site; other site
983548006932	dimerization interface [polypeptide binding]; other site
983548006933	PglZ domain; Region: PglZ; pfam08665
983548006934	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
983548006935	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548006936	Zn2+ binding site [ion binding]; other site
983548006937	Mg2+ binding site [ion binding]; other site
983548006938	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
983548006939	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
983548006940	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
983548006941	trimer interface [polypeptide binding]; other site
983548006942	active site
983548006943	UDP-GlcNAc binding site [chemical binding]; other site
983548006944	lipid binding site [chemical binding]; lipid-binding site
983548006945	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
983548006946	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
983548006947	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
983548006948	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
983548006949	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
983548006950	active site
983548006951	elongation factor P; Validated; Region: PRK00529
983548006952	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
983548006953	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
983548006954	RNA binding site [nucleotide binding]; other site
983548006955	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
983548006956	RNA binding site [nucleotide binding]; other site
983548006957	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
983548006958	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
983548006959	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
983548006960	trimer interface [polypeptide binding]; other site
983548006961	active site
983548006962	UDP-GlcNAc binding site [chemical binding]; other site
983548006963	lipid binding site [chemical binding]; lipid-binding site
983548006964	SnoaL-like domain; Region: SnoaL_2; pfam12680
983548006965	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
983548006966	CoA binding domain; Region: CoA_binding; smart00881
983548006967	CoA-ligase; Region: Ligase_CoA; pfam00549
983548006968	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
983548006969	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
983548006970	NAD(P) binding site [chemical binding]; other site
983548006971	homotetramer interface [polypeptide binding]; other site
983548006972	homodimer interface [polypeptide binding]; other site
983548006973	active site
983548006974	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
983548006975	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_1; cd03400
983548006976	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
983548006977	Protein of unknown function (DUF2874); Region: DUF2874; pfam11396
983548006978	Uncharacterized conserved protein [Function unknown]; Region: COG3743
983548006979	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548006980	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548006981	ligand binding site [chemical binding]; other site
983548006982	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
983548006983	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
983548006984	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
983548006985	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
983548006986	histidinol dehydrogenase; Region: hisD; TIGR00069
983548006987	NAD binding site [chemical binding]; other site
983548006988	dimerization interface [polypeptide binding]; other site
983548006989	product binding site; other site
983548006990	substrate binding site [chemical binding]; other site
983548006991	zinc binding site [ion binding]; other site
983548006992	catalytic residues [active]
983548006993	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
983548006994	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
983548006995	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548006996	homodimer interface [polypeptide binding]; other site
983548006997	catalytic residue [active]
983548006998	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
983548006999	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
983548007000	active site
983548007001	motif I; other site
983548007002	motif II; other site
983548007003	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
983548007004	putative active site pocket [active]
983548007005	4-fold oligomerization interface [polypeptide binding]; other site
983548007006	metal binding residues [ion binding]; metal-binding site
983548007007	3-fold/trimer interface [polypeptide binding]; other site
983548007008	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
983548007009	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
983548007010	putative active site [active]
983548007011	oxyanion strand; other site
983548007012	catalytic triad [active]
983548007013	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
983548007014	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
983548007015	catalytic residues [active]
983548007016	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
983548007017	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
983548007018	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548007019	Cupin domain; Region: Cupin_2; pfam07883
983548007020	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
983548007021	Zonular occludens toxin (Zot); Region: Zot; cl17485
983548007022	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
983548007023	homotrimer interaction site [polypeptide binding]; other site
983548007024	putative active site [active]
983548007025	Protein of unknown function (DUF3276); Region: DUF3276; pfam11680
983548007026	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
983548007027	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
983548007028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548007029	Walker A/P-loop; other site
983548007030	ATP binding site [chemical binding]; other site
983548007031	Q-loop/lid; other site
983548007032	ABC transporter signature motif; other site
983548007033	Walker B; other site
983548007034	D-loop; other site
983548007035	H-loop/switch region; other site
983548007036	transcription antitermination factor NusB; Region: nusB; TIGR01951
983548007037	Protein of unknown function (DUF1573); Region: DUF1573; pfam07610
983548007038	Preprotein translocase subunit; Region: YajC; pfam02699
983548007039	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
983548007040	E-class dimer interface [polypeptide binding]; other site
983548007041	P-class dimer interface [polypeptide binding]; other site
983548007042	active site
983548007043	Cu2+ binding site [ion binding]; other site
983548007044	Zn2+ binding site [ion binding]; other site
983548007045	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
983548007046	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
983548007047	Protein of unknown function (DUF2490); Region: DUF2490; pfam10677
983548007048	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
983548007049	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
983548007050	Fasciclin domain; Region: Fasciclin; pfam02469
983548007051	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
983548007052	metal ion-dependent adhesion site (MIDAS); other site
983548007053	Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239
983548007054	LysM domain/BON superfamily protein; Provisional; Region: PRK11198
983548007055	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
983548007056	Protein of unknown function (DUF2807); Region: DUF2807; pfam10988
983548007057	NAD-dependent deacetylase; Provisional; Region: PRK00481
983548007058	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
983548007059	NAD+ binding site [chemical binding]; other site
983548007060	substrate binding site [chemical binding]; other site
983548007061	Zn binding site [ion binding]; other site
983548007062	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
983548007063	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
983548007064	putative catalytic residues [active]
983548007065	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548007066	helicase 45; Provisional; Region: PTZ00424
983548007067	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
983548007068	ATP binding site [chemical binding]; other site
983548007069	Mg++ binding site [ion binding]; other site
983548007070	motif III; other site
983548007071	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548007072	nucleotide binding region [chemical binding]; other site
983548007073	ATP-binding site [chemical binding]; other site
983548007074	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
983548007075	RNA binding site [nucleotide binding]; other site
983548007076	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
983548007077	active site
983548007078	dimerization interface [polypeptide binding]; other site
983548007079	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
983548007080	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
983548007081	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
983548007082	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
983548007083	dimerization interface [polypeptide binding]; other site
983548007084	active site
983548007085	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
983548007086	Chalcone-flavanone isomerase; Region: Chalcone; cl03589
983548007087	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
983548007088	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548007089	primosomal protein N' Region: priA; TIGR00595
983548007090	ATP binding site [chemical binding]; other site
983548007091	putative Mg++ binding site [ion binding]; other site
983548007092	helicase superfamily c-terminal domain; Region: HELICc; smart00490
983548007093	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
983548007094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548007095	active site
983548007096	phosphorylation site [posttranslational modification]
983548007097	intermolecular recognition site; other site
983548007098	dimerization interface [polypeptide binding]; other site
983548007099	LytTr DNA-binding domain; Region: LytTR; smart00850
983548007100	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
983548007101	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
983548007102	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
983548007103	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
983548007104	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
983548007105	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
983548007106	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
983548007107	ATP binding site [chemical binding]; other site
983548007108	putative Mg++ binding site [ion binding]; other site
983548007109	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548007110	nucleotide binding region [chemical binding]; other site
983548007111	ATP-binding site [chemical binding]; other site
983548007112	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
983548007113	RNA binding site [nucleotide binding]; other site
983548007114	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
983548007115	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
983548007116	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
983548007117	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548007118	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548007119	catalytic residues [active]
983548007120	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
983548007121	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548007122	ligand binding site [chemical binding]; other site
983548007123	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548007124	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548007125	ligand binding site [chemical binding]; other site
983548007126	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
983548007127	Clp amino terminal domain; Region: Clp_N; pfam02861
983548007128	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548007129	Walker A motif; other site
983548007130	ATP binding site [chemical binding]; other site
983548007131	Walker B motif; other site
983548007132	arginine finger; other site
983548007133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548007134	Walker A motif; other site
983548007135	ATP binding site [chemical binding]; other site
983548007136	Walker B motif; other site
983548007137	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
983548007138	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
983548007139	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
983548007140	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
983548007141	DNA-binding site [nucleotide binding]; DNA binding site
983548007142	RNA-binding motif; other site
983548007143	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
983548007144	putative active site [active]
983548007145	heme pocket [chemical binding]; other site
983548007146	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548007147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548007148	ATP binding site [chemical binding]; other site
983548007149	Mg2+ binding site [ion binding]; other site
983548007150	G-X-G motif; other site
983548007151	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
983548007152	HSP70 interaction site [polypeptide binding]; other site
983548007153	KTSC domain; Region: KTSC; pfam13619
983548007154	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
983548007155	DEAD-like helicases superfamily; Region: DEXDc; smart00487
983548007156	ATP binding site [chemical binding]; other site
983548007157	Mg++ binding site [ion binding]; other site
983548007158	motif III; other site
983548007159	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548007160	nucleotide binding region [chemical binding]; other site
983548007161	ATP-binding site [chemical binding]; other site
983548007162	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cl00248
983548007163	substrate binding site [chemical binding]; other site
983548007164	dimerization interface [polypeptide binding]; other site
983548007165	active site
983548007166	calcium binding site [ion binding]; other site
983548007167	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
983548007168	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
983548007169	active site
983548007170	Zn binding site [ion binding]; other site
983548007171	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
983548007172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548007173	NAD(P) binding site [chemical binding]; other site
983548007174	active site
983548007175	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
983548007176	active site
983548007177	catalytic triad [active]
983548007178	oxyanion hole [active]
983548007179	switch loop; other site
983548007180	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
983548007181	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
983548007182	Walker A/P-loop; other site
983548007183	ATP binding site [chemical binding]; other site
983548007184	Q-loop/lid; other site
983548007185	ABC transporter signature motif; other site
983548007186	Walker B; other site
983548007187	D-loop; other site
983548007188	H-loop/switch region; other site
983548007189	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
983548007190	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
983548007191	FtsX-like permease family; Region: FtsX; pfam02687
983548007192	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
983548007193	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
983548007194	potential catalytic triad [active]
983548007195	conserved cys residue [active]
983548007196	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
983548007197	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
983548007198	dimer interface [polypeptide binding]; other site
983548007199	active site
983548007200	metal binding site [ion binding]; metal-binding site
983548007201	Prostaglandin dehydrogenases; Region: PGDH; cd05288
983548007202	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
983548007203	NAD(P) binding site [chemical binding]; other site
983548007204	substrate binding site [chemical binding]; other site
983548007205	dimer interface [polypeptide binding]; other site
983548007206	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
983548007207	dimer interface [polypeptide binding]; other site
983548007208	FMN binding site [chemical binding]; other site
983548007209	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
983548007210	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
983548007211	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
983548007212	EamA-like transporter family; Region: EamA; cl17759
983548007213	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
983548007214	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548007215	NAD(P) binding site [chemical binding]; other site
983548007216	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548007217	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
983548007218	active site
983548007219	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
983548007220	DNA-binding site [nucleotide binding]; DNA binding site
983548007221	RNA-binding motif; other site
983548007222	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
983548007223	thiamine phosphate binding site [chemical binding]; other site
983548007224	active site
983548007225	pyrophosphate binding site [ion binding]; other site
983548007226	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
983548007227	Fasciclin domain; Region: Fasciclin; pfam02469
983548007228	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
983548007229	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
983548007230	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
983548007231	molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878
983548007232	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
983548007233	ATP binding site [chemical binding]; other site
983548007234	substrate interface [chemical binding]; other site
983548007235	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
983548007236	active site residue [active]
983548007237	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
983548007238	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
983548007239	FeS/SAM binding site; other site
983548007240	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
983548007241	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
983548007242	ThiS interaction site; other site
983548007243	putative active site [active]
983548007244	tetramer interface [polypeptide binding]; other site
983548007245	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
983548007246	thiamine phosphate binding site [chemical binding]; other site
983548007247	active site
983548007248	pyrophosphate binding site [ion binding]; other site
983548007249	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
983548007250	dimer interface [polypeptide binding]; other site
983548007251	substrate binding site [chemical binding]; other site
983548007252	ATP binding site [chemical binding]; other site
983548007253	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
983548007254	thiamine phosphate binding site [chemical binding]; other site
983548007255	active site
983548007256	pyrophosphate binding site [ion binding]; other site
983548007257	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
983548007258	ThiC-associated domain; Region: ThiC-associated; pfam13667
983548007259	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
983548007260	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
983548007261	thiS-thiF/thiG interaction site; other site
983548007262	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
983548007263	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
983548007264	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548007265	dimer interface [polypeptide binding]; other site
983548007266	phosphorylation site [posttranslational modification]
983548007267	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548007268	ATP binding site [chemical binding]; other site
983548007269	Mg2+ binding site [ion binding]; other site
983548007270	G-X-G motif; other site
983548007271	TPR repeat; Region: TPR_11; pfam13414
983548007272	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548007273	binding surface
983548007274	TPR motif; other site
983548007275	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
983548007276	binding surface
983548007277	TPR motif; other site
983548007278	Tetratricopeptide repeat; Region: TPR_12; pfam13424
983548007279	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548007280	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548007281	dimer interface [polypeptide binding]; other site
983548007282	phosphorylation site [posttranslational modification]
983548007283	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548007284	ATP binding site [chemical binding]; other site
983548007285	Mg2+ binding site [ion binding]; other site
983548007286	G-X-G motif; other site
983548007287	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
983548007288	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548007289	active site
983548007290	phosphorylation site [posttranslational modification]
983548007291	intermolecular recognition site; other site
983548007292	dimerization interface [polypeptide binding]; other site
983548007293	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
983548007294	Active site serine [active]
983548007295	Tetratricopeptide repeat; Region: TPR_6; pfam13174
983548007296	Domain of unknown function (DUF4251); Region: DUF4251; pfam14059
983548007297	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
983548007298	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548007299	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
983548007300	nucleoside/Zn binding site; other site
983548007301	dimer interface [polypeptide binding]; other site
983548007302	catalytic motif [active]
983548007303	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
983548007304	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
983548007305	NAD(P) binding site [chemical binding]; other site
983548007306	catalytic residues [active]
983548007307	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
983548007308	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
983548007309	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
983548007310	active site
983548007311	dimer interface [polypeptide binding]; other site
983548007312	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
983548007313	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548007314	ATP binding site [chemical binding]; other site
983548007315	putative Mg++ binding site [ion binding]; other site
983548007316	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548007317	nucleotide binding region [chemical binding]; other site
983548007318	ATP-binding site [chemical binding]; other site
983548007319	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
983548007320	homodecamer interface [polypeptide binding]; other site
983548007321	GTP cyclohydrolase I; Provisional; Region: PLN03044
983548007322	active site
983548007323	putative catalytic site residues [active]
983548007324	zinc binding site [ion binding]; other site
983548007325	GTP-CH-I/GFRP interaction surface; other site
983548007326	DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618
983548007327	putative ligand binding site [chemical binding]; other site
983548007328	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
983548007329	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
983548007330	Walker A/P-loop; other site
983548007331	ATP binding site [chemical binding]; other site
983548007332	Q-loop/lid; other site
983548007333	ABC transporter signature motif; other site
983548007334	Walker B; other site
983548007335	D-loop; other site
983548007336	H-loop/switch region; other site
983548007337	Protein of unknown function (DUF2400); Region: DUF2400; pfam09674
983548007338	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
983548007339	GAF domain; Region: GAF; pfam01590
983548007340	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548007341	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
983548007342	dimer interface [polypeptide binding]; other site
983548007343	phosphorylation site [posttranslational modification]
983548007344	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548007345	ATP binding site [chemical binding]; other site
983548007346	Mg2+ binding site [ion binding]; other site
983548007347	G-X-G motif; other site
983548007348	Aerotolerance regulator N-terminal; Region: BatA; pfam07584
983548007349	dihydroorotase; Validated; Region: pyrC; PRK09357
983548007350	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
983548007351	active site
983548007352	Predicted membrane protein [Function unknown]; Region: COG4818
983548007353	Predicted esterase [General function prediction only]; Region: COG0400
983548007354	putative hydrolase; Provisional; Region: PRK11460
983548007355	putative hydrolase; Provisional; Region: PRK02113
983548007356	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
983548007357	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
983548007358	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
983548007359	catalytic triad [active]
983548007360	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
983548007361	endonuclease III; Region: ENDO3c; smart00478
983548007362	minor groove reading motif; other site
983548007363	helix-hairpin-helix signature motif; other site
983548007364	substrate binding pocket [chemical binding]; other site
983548007365	active site
983548007366	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548007367	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548007368	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548007369	DNA binding residues [nucleotide binding]
983548007370	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
983548007371	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
983548007372	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
983548007373	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
983548007374	IKI3 family; Region: IKI3; pfam04762
983548007375	Domon-like ligand-binding domains; Region: DOMON_like; cd00241
983548007376	putative ligand binding site [chemical binding]; other site
983548007377	M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase (AAP)-like; Region: M28_AAP_like; cd05642
983548007378	Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234
983548007379	putative metal binding site [ion binding]; other site
983548007380	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
983548007381	Interdomain contacts; other site
983548007382	Cytokine receptor motif; other site
983548007383	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
983548007384	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
983548007385	metal binding site [ion binding]; metal-binding site
983548007386	putative dimer interface [polypeptide binding]; other site
983548007387	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
983548007388	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548007389	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
983548007390	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like2; cd05667
983548007391	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
983548007392	metal binding site [ion binding]; metal-binding site
983548007393	putative dimer interface [polypeptide binding]; other site
983548007394	Penicillinase repressor; Region: Pencillinase_R; pfam03965
983548007395	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
983548007396	TonB-dependent outer membrane receptor, SusC/RagA subfamily, signature region; Region: SusC_RagA_signa; TIGR04057
983548007397	putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272
983548007398	EamA-like transporter family; Region: EamA; pfam00892
983548007399	EamA-like transporter family; Region: EamA; pfam00892
983548007400	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548007401	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
983548007402	ligand binding site [chemical binding]; other site
983548007403	flexible hinge region; other site
983548007404	Fatty acid desaturase; Region: FA_desaturase; pfam00487
983548007405	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
983548007406	Di-iron ligands [ion binding]; other site
983548007407	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
983548007408	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
983548007409	malate:quinone oxidoreductase; Validated; Region: PRK05257
983548007410	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
983548007411	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
983548007412	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
983548007413	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548007414	Family of unknown function (DUF490); Region: DUF490; pfam04357
983548007415	Fasciclin domain; Region: Fasciclin; pfam02469
983548007416	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
983548007417	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
983548007418	putative NAD(P) binding site [chemical binding]; other site
983548007419	putative substrate binding site [chemical binding]; other site
983548007420	catalytic Zn binding site [ion binding]; other site
983548007421	structural Zn binding site [ion binding]; other site
983548007422	dimer interface [polypeptide binding]; other site
983548007423	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
983548007424	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
983548007425	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
983548007426	FMN binding site [chemical binding]; other site
983548007427	active site
983548007428	substrate binding site [chemical binding]; other site
983548007429	catalytic residue [active]
983548007430	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
983548007431	EF-hand domain pair; Region: EF_hand_5; pfam13499
983548007432	Ca2+ binding site [ion binding]; other site
983548007433	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
983548007434	active site
983548007435	catalytic site [active]
983548007436	substrate binding site [chemical binding]; other site
983548007437	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
983548007438	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
983548007439	GIY-YIG motif/motif A; other site
983548007440	active site
983548007441	catalytic site [active]
983548007442	putative DNA binding site [nucleotide binding]; other site
983548007443	metal binding site [ion binding]; metal-binding site
983548007444	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
983548007445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548007446	S-adenosylmethionine binding site [chemical binding]; other site
983548007447	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
983548007448	pseudouridine synthase; Region: TIGR00093
983548007449	active site
983548007450	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
983548007451	DNA-binding site [nucleotide binding]; DNA binding site
983548007452	RNA-binding motif; other site
983548007453	DoxX-like family; Region: DoxX_2; pfam13564
983548007454	DoxX-like family; Region: DoxX_2; pfam13564
983548007455	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
983548007456	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
983548007457	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
983548007458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548007459	Walker A/P-loop; other site
983548007460	ATP binding site [chemical binding]; other site
983548007461	Q-loop/lid; other site
983548007462	ABC transporter signature motif; other site
983548007463	Walker B; other site
983548007464	D-loop; other site
983548007465	H-loop/switch region; other site
983548007466	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
983548007467	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
983548007468	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
983548007469	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548007470	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
983548007471	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
983548007472	DNA binding residues [nucleotide binding]
983548007473	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
983548007474	16S rRNA methyltransferase B; Provisional; Region: PRK14902
983548007475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548007476	S-adenosylmethionine binding site [chemical binding]; other site
983548007477	CARDB; Region: CARDB; pfam07705
983548007478	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548007479	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
983548007480	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
983548007481	dimerization interface [polypeptide binding]; other site
983548007482	ATP binding site [chemical binding]; other site
983548007483	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
983548007484	dimerization interface [polypeptide binding]; other site
983548007485	ATP binding site [chemical binding]; other site
983548007486	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
983548007487	putative active site [active]
983548007488	catalytic triad [active]
983548007489	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
983548007490	active site
983548007491	Zn binding site [ion binding]; other site
983548007492	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
983548007493	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548007494	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
983548007495	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
983548007496	acyl-activating enzyme (AAE) consensus motif; other site
983548007497	putative AMP binding site [chemical binding]; other site
983548007498	putative active site [active]
983548007499	putative CoA binding site [chemical binding]; other site
983548007500	Phospholipid methyltransferase; Region: PEMT; cl17370
983548007501	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
983548007502	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
983548007503	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
983548007504	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
983548007505	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
983548007506	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
983548007507	Zn binding site [ion binding]; other site
983548007508	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
983548007509	tetramer interface [polypeptide binding]; other site
983548007510	TPP-binding site [chemical binding]; other site
983548007511	heterodimer interface [polypeptide binding]; other site
983548007512	phosphorylation loop region [posttranslational modification]
983548007513	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
983548007514	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
983548007515	PYR/PP interface [polypeptide binding]; other site
983548007516	dimer interface [polypeptide binding]; other site
983548007517	TPP binding site [chemical binding]; other site
983548007518	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
983548007519	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
983548007520	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
983548007521	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548007522	Zn2+ binding site [ion binding]; other site
983548007523	Mg2+ binding site [ion binding]; other site
983548007524	acetyl-CoA C-acetyltransferase; Region: PLN02644
983548007525	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
983548007526	dimer interface [polypeptide binding]; other site
983548007527	active site
983548007528	Bacterial SH3 domain; Region: SH3_4; pfam06347
983548007529	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
983548007530	NlpC/P60 family; Region: NLPC_P60; pfam00877
983548007531	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548007532	binding surface
983548007533	TPR motif; other site
983548007534	TPR repeat; Region: TPR_11; pfam13414
983548007535	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
983548007536	binding surface
983548007537	TPR motif; other site
983548007538	DNA gyrase subunit A; Validated; Region: PRK05560
983548007539	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
983548007540	CAP-like domain; other site
983548007541	active site
983548007542	primary dimer interface [polypeptide binding]; other site
983548007543	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
983548007544	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
983548007545	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
983548007546	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
983548007547	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
983548007548	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
983548007549	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
983548007550	Clp amino terminal domain; Region: Clp_N; pfam02861
983548007551	Clp amino terminal domain; Region: Clp_N; pfam02861
983548007552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548007553	Walker A motif; other site
983548007554	ATP binding site [chemical binding]; other site
983548007555	Walker B motif; other site
983548007556	arginine finger; other site
983548007557	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548007558	Walker A motif; other site
983548007559	ATP binding site [chemical binding]; other site
983548007560	Walker B motif; other site
983548007561	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
983548007562	short chain dehydrogenase; Provisional; Region: PRK07326
983548007563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548007564	NAD(P) binding site [chemical binding]; other site
983548007565	active site
983548007566	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
983548007567	integral membrane protein; Region: integ_memb_HG; TIGR03954
983548007568	Tic20-like protein; Region: Tic20; pfam09685
983548007569	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
983548007570	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
983548007571	trmE is a tRNA modification GTPase; Region: trmE; cd04164
983548007572	G1 box; other site
983548007573	GTP/Mg2+ binding site [chemical binding]; other site
983548007574	Switch I region; other site
983548007575	G2 box; other site
983548007576	Switch II region; other site
983548007577	G3 box; other site
983548007578	G4 box; other site
983548007579	G5 box; other site
983548007580	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
983548007581	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
983548007582	generic binding surface II; other site
983548007583	generic binding surface I; other site
983548007584	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
983548007585	putative catalytic site [active]
983548007586	putative metal binding site [ion binding]; other site
983548007587	putative phosphate binding site [ion binding]; other site
983548007588	Por secretion system C-terminal sorting domain; Region: Por_Secre_tail; TIGR04183
983548007589	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
983548007590	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
983548007591	active site
983548007592	FMN binding site [chemical binding]; other site
983548007593	substrate binding site [chemical binding]; other site
983548007594	homotetramer interface [polypeptide binding]; other site
983548007595	catalytic residue [active]
983548007596	Capsule assembly protein Wzi; Region: Caps_assemb_Wzi; pfam14052
983548007597	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
983548007598	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
983548007599	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
983548007600	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
983548007601	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
983548007602	SLBB domain; Region: SLBB; pfam10531
983548007603	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
983548007604	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
983548007605	NAD(P) binding site [chemical binding]; other site
983548007606	homodimer interface [polypeptide binding]; other site
983548007607	substrate binding site [chemical binding]; other site
983548007608	active site
983548007609	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
983548007610	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
983548007611	inhibitor-cofactor binding pocket; inhibition site
983548007612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548007613	catalytic residue [active]
983548007614	Bacterial sugar transferase; Region: Bac_transf; pfam02397
983548007615	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
983548007616	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
983548007617	putative trimer interface [polypeptide binding]; other site
983548007618	putative CoA binding site [chemical binding]; other site
983548007619	Bacterial sugar transferase; Region: Bac_transf; pfam02397
983548007620	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
983548007621	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548007622	putative ADP-binding pocket [chemical binding]; other site
983548007623	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
983548007624	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548007625	Glycosyl transferases group 1; Region: Glycos_transf_1; pfam00534
983548007626	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
983548007627	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
983548007628	active site
983548007629	homodimer interface [polypeptide binding]; other site
983548007630	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
983548007631	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
983548007632	NAD(P) binding site [chemical binding]; other site
983548007633	active site
983548007634	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
983548007635	WxcM-like, C-terminal; Region: FdtA; pfam05523
983548007636	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
983548007637	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
983548007638	NAD(P) binding site [chemical binding]; other site
983548007639	homodimer interface [polypeptide binding]; other site
983548007640	substrate binding site [chemical binding]; other site
983548007641	active site
983548007642	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
983548007643	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
983548007644	trimer interface [polypeptide binding]; other site
983548007645	CoA binding site [chemical binding]; other site
983548007646	active site
983548007647	FOG: CBS domain [General function prediction only]; Region: COG0517
983548007648	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
983548007649	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
983548007650	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
983548007651	Substrate binding site; other site
983548007652	metal-binding site
983548007653	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
983548007654	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
983548007655	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
983548007656	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
983548007657	Coenzyme A binding pocket [chemical binding]; other site
983548007658	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368
983548007659	hypothetical protein; Provisional; Region: PRK07206
983548007660	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
983548007661	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
983548007662	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
983548007663	inhibitor-cofactor binding pocket; inhibition site
983548007664	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548007665	catalytic residue [active]
983548007666	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082
983548007667	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
983548007668	NAD(P) binding site [chemical binding]; other site
983548007669	homodimer interface [polypeptide binding]; other site
983548007670	substrate binding site [chemical binding]; other site
983548007671	active site
983548007672	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
983548007673	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
983548007674	NAD binding site [chemical binding]; other site
983548007675	putative substrate binding site 2 [chemical binding]; other site
983548007676	putative substrate binding site 1 [chemical binding]; other site
983548007677	active site
983548007678	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
983548007679	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
983548007680	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
983548007681	SLBB domain; Region: SLBB; pfam10531
983548007682	SLBB domain; Region: SLBB; pfam10531
983548007683	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
983548007684	probable UDP-glucose 6-dehydrogenase; Region: PLN02353
983548007685	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
983548007686	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
983548007687	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
983548007688	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
983548007689	putative NAD(P) binding site [chemical binding]; other site
983548007690	active site
983548007691	putative substrate binding site [chemical binding]; other site
983548007692	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
983548007693	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
983548007694	active site
983548007695	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
983548007696	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
983548007697	NADP binding site [chemical binding]; other site
983548007698	active site
983548007699	putative substrate binding site [chemical binding]; other site
983548007700	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
983548007701	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
983548007702	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
983548007703	substrate binding site; other site
983548007704	tetramer interface; other site
983548007705	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
983548007706	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
983548007707	NAD binding site [chemical binding]; other site
983548007708	substrate binding site [chemical binding]; other site
983548007709	homodimer interface [polypeptide binding]; other site
983548007710	active site
983548007711	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
983548007712	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
983548007713	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
983548007714	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
983548007715	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
983548007716	NAD binding site [chemical binding]; other site
983548007717	substrate binding site [chemical binding]; other site
983548007718	homodimer interface [polypeptide binding]; other site
983548007719	active site
983548007720	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
983548007721	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
983548007722	dimerization interface [polypeptide binding]; other site
983548007723	DPS ferroxidase diiron center [ion binding]; other site
983548007724	ion pore; other site
983548007725	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
983548007726	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
983548007727	putative acyl-acceptor binding pocket; other site
983548007728	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
983548007729	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
983548007730	Ligand binding site; other site
983548007731	oligomer interface; other site
983548007732	Domain of unknown function (DUF4126); Region: DUF4126; pfam13548
983548007733	AAA domain; Region: AAA_30; pfam13604
983548007734	Family description; Region: UvrD_C_2; pfam13538
983548007735	Protein of unknown function (DUF3822); Region: DUF3822; pfam12864
983548007736	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
983548007737	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548007738	S-adenosylmethionine binding site [chemical binding]; other site
983548007739	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
983548007740	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
983548007741	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
983548007742	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
983548007743	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
983548007744	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
983548007745	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
983548007746	Uncharacterized archaeal Zn-finger protein [General function prediction only]; Region: COG1326
983548007747	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
983548007748	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
983548007749	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
983548007750	S-adenosylmethionine binding site [chemical binding]; other site
983548007751	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
983548007752	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
983548007753	DNA-binding site [nucleotide binding]; DNA binding site
983548007754	RNA-binding motif; other site
983548007755	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
983548007756	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
983548007757	RNA binding surface [nucleotide binding]; other site
983548007758	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
983548007759	probable active site [active]
983548007760	Uncharacterized conserved protein [Function unknown]; Region: COG2968
983548007761	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
983548007762	Rhomboid family; Region: Rhomboid; cl11446
983548007763	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
983548007764	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
983548007765	putative acyl-acceptor binding pocket; other site
983548007766	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
983548007767	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548007768	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548007769	catalytic residue [active]
983548007770	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
983548007771	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
983548007772	active site
983548007773	substrate binding site [chemical binding]; other site
983548007774	metal binding site [ion binding]; metal-binding site
983548007775	Protein of unknown function, DUF479; Region: DUF479; cl01203
983548007776	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
983548007777	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
983548007778	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
983548007779	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548007780	putative substrate translocation pore; other site
983548007781	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
983548007782	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
983548007783	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
983548007784	GAF domain; Region: GAF; pfam01590
983548007785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
983548007786	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
983548007787	ATP binding site [chemical binding]; other site
983548007788	Mg2+ binding site [ion binding]; other site
983548007789	G-X-G motif; other site
983548007790	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
983548007791	MarR family; Region: MarR_2; pfam12802
983548007792	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
983548007793	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
983548007794	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
983548007795	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
983548007796	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
983548007797	substrate binding site [chemical binding]; other site
983548007798	oxyanion hole (OAH) forming residues; other site
983548007799	trimer interface [polypeptide binding]; other site
983548007800	S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635
983548007801	four helix bundle protein; Region: TIGR02436
983548007802	acetyl-CoA acetyltransferase; Provisional; Region: PRK09052
983548007803	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
983548007804	dimer interface [polypeptide binding]; other site
983548007805	active site
983548007806	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
983548007807	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
983548007808	active site
983548007809	pyruvate carboxylase; Reviewed; Region: PRK12999
983548007810	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
983548007811	ATP-grasp domain; Region: ATP-grasp_4; cl17255
983548007812	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
983548007813	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
983548007814	active site
983548007815	catalytic residues [active]
983548007816	metal binding site [ion binding]; metal-binding site
983548007817	homodimer binding site [polypeptide binding]; other site
983548007818	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
983548007819	carboxyltransferase (CT) interaction site; other site
983548007820	biotinylation site [posttranslational modification]; other site
983548007821	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
983548007822	PLD-like domain; Region: PLDc_2; pfam13091
983548007823	putative homodimer interface [polypeptide binding]; other site
983548007824	putative active site [active]
983548007825	catalytic site [active]
983548007826	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
983548007827	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548007828	ATP binding site [chemical binding]; other site
983548007829	putative Mg++ binding site [ion binding]; other site
983548007830	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548007831	nucleotide binding region [chemical binding]; other site
983548007832	ATP-binding site [chemical binding]; other site
983548007833	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
983548007834	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
983548007835	Catalytic site [active]
983548007836	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
983548007837	active site
983548007838	8-oxo-dGMP binding site [chemical binding]; other site
983548007839	nudix motif; other site
983548007840	metal binding site [ion binding]; metal-binding site
983548007841	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548007842	putative substrate translocation pore; other site
983548007843	Major Facilitator Superfamily; Region: MFS_1; pfam07690
983548007844	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
983548007845	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
983548007846	FMN binding site [chemical binding]; other site
983548007847	active site
983548007848	catalytic residues [active]
983548007849	substrate binding site [chemical binding]; other site
983548007850	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
983548007851	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
983548007852	active site
983548007853	catalytic site [active]
983548007854	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
983548007855	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
983548007856	PA/protease or protease-like domain interface [polypeptide binding]; other site
983548007857	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
983548007858	Peptidase family M28; Region: Peptidase_M28; pfam04389
983548007859	metal binding site [ion binding]; metal-binding site
983548007860	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
983548007861	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548007862	SnoaL-like domain; Region: SnoaL_2; pfam12680
983548007863	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
983548007864	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
983548007865	active site
983548007866	catalytic residues [active]
983548007867	metal binding site [ion binding]; metal-binding site
983548007868	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
983548007869	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
983548007870	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
983548007871	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548007872	Coenzyme A binding pocket [chemical binding]; other site
983548007873	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
983548007874	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
983548007875	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
983548007876	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
983548007877	6-phosphofructokinase; Provisional; Region: PRK03202
983548007878	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
983548007879	active site
983548007880	ADP/pyrophosphate binding site [chemical binding]; other site
983548007881	dimerization interface [polypeptide binding]; other site
983548007882	allosteric effector site; other site
983548007883	fructose-1,6-bisphosphate binding site; other site
983548007884	Family of unknown function (DUF490); Region: DUF490; pfam04357
983548007885	Family of unknown function (DUF490); Region: DUF490; pfam04357
983548007886	UGMP family protein; Validated; Region: PRK09604
983548007887	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
983548007888	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
983548007889	RNA methyltransferase, RsmE family; Region: TIGR00046
983548007890	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
983548007891	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548007892	Outer membrane protein beta-barrel domain; Region: OMP_b-brl_2; pfam13568
983548007893	exopolyphosphatase; Region: exo_poly_only; TIGR03706
983548007894	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
983548007895	polyphosphate kinase; Provisional; Region: PRK05443
983548007896	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
983548007897	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
983548007898	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
983548007899	domain interface [polypeptide binding]; other site
983548007900	active site
983548007901	catalytic site [active]
983548007902	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
983548007903	domain interface [polypeptide binding]; other site
983548007904	active site
983548007905	catalytic site [active]
983548007906	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
983548007907	catalytic core [active]
983548007908	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
983548007909	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
983548007910	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
983548007911	ribonuclease Z; Reviewed; Region: PRK00055
983548007912	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
983548007913	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
983548007914	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
983548007915	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
983548007916	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
983548007917	active site
983548007918	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
983548007919	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
983548007920	Ca binding site [ion binding]; other site
983548007921	active site
983548007922	catalytic site [active]
983548007923	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
983548007924	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
983548007925	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
983548007926	quinone interaction residues [chemical binding]; other site
983548007927	active site
983548007928	catalytic residues [active]
983548007929	FMN binding site [chemical binding]; other site
983548007930	substrate binding site [chemical binding]; other site
983548007931	peptidase T; Region: peptidase-T; TIGR01882
983548007932	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
983548007933	metal binding site [ion binding]; metal-binding site
983548007934	dimer interface [polypeptide binding]; other site
983548007935	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
983548007936	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
983548007937	active site
983548007938	phosphorylation site [posttranslational modification]
983548007939	intermolecular recognition site; other site
983548007940	dimerization interface [polypeptide binding]; other site
983548007941	LytTr DNA-binding domain; Region: LytTR; smart00850
983548007942	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548007943	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
983548007944	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
983548007945	active site
983548007946	2TM domain; Region: 2TM; pfam13239
983548007947	2TM domain; Region: 2TM; pfam13239
983548007948	2TM domain; Region: 2TM; pfam13239
983548007949	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14970
983548007950	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
983548007951	Walker A motif; other site
983548007952	ATP binding site [chemical binding]; other site
983548007953	Walker B motif; other site
983548007954	arginine finger; other site
983548007955	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
983548007956	active site
983548007957	dinuclear metal binding site [ion binding]; other site
983548007958	dimerization interface [polypeptide binding]; other site
983548007959	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548007960	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548007961	catalytic residues [active]
983548007962	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
983548007963	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
983548007964	ligand binding site [chemical binding]; other site
983548007965	flexible hinge region; other site
983548007966	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
983548007967	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
983548007968	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
983548007969	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
983548007970	catalytic motif [active]
983548007971	Catalytic residue [active]
983548007972	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
983548007973	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
983548007974	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
983548007975	putative active site [active]
983548007976	putative NTP binding site [chemical binding]; other site
983548007977	putative nucleic acid binding site [nucleotide binding]; other site
983548007978	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
983548007979	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548007980	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548007981	catalytic residues [active]
983548007982	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
983548007983	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
983548007984	salt bridge; other site
983548007985	non-specific DNA binding site [nucleotide binding]; other site
983548007986	sequence-specific DNA binding site [nucleotide binding]; other site
983548007987	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
983548007988	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
983548007989	putative active site [active]
983548007990	catalytic site [active]
983548007991	putative metal binding site [ion binding]; other site
983548007992	oligomer interface [polypeptide binding]; other site
983548007993	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
983548007994	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
983548007995	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
983548007996	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
983548007997	Zn binding site [ion binding]; other site
983548007998	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
983548007999	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
983548008000	ssDNA binding site; other site
983548008001	generic binding surface II; other site
983548008002	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
983548008003	ATP binding site [chemical binding]; other site
983548008004	putative Mg++ binding site [ion binding]; other site
983548008005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548008006	nucleotide binding region [chemical binding]; other site
983548008007	ATP-binding site [chemical binding]; other site
983548008008	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548008009	catalytic residues [active]
983548008010	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
983548008011	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
983548008012	putative tRNA-binding site [nucleotide binding]; other site
983548008013	B3/4 domain; Region: B3_4; pfam03483
983548008014	tRNA synthetase B5 domain; Region: B5; pfam03484
983548008015	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
983548008016	dimer interface [polypeptide binding]; other site
983548008017	motif 1; other site
983548008018	motif 3; other site
983548008019	motif 2; other site
983548008020	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
983548008021	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
983548008022	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
983548008023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548008024	Walker A/P-loop; other site
983548008025	ATP binding site [chemical binding]; other site
983548008026	Q-loop/lid; other site
983548008027	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548008028	ABC transporter signature motif; other site
983548008029	Walker B; other site
983548008030	D-loop; other site
983548008031	ABC transporter; Region: ABC_tran_2; pfam12848
983548008032	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548008033	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
983548008034	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548008035	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
983548008036	active site
983548008037	intersubunit interactions; other site
983548008038	catalytic residue [active]
983548008039	short chain dehydrogenase; Validated; Region: PRK06182
983548008040	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
983548008041	NADP binding site [chemical binding]; other site
983548008042	active site
983548008043	steroid binding site; other site
983548008044	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
983548008045	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548008046	catalytic residues [active]
983548008047	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
983548008048	dimer interface [polypeptide binding]; other site
983548008049	FMN binding site [chemical binding]; other site
983548008050	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
983548008051	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
983548008052	putative active site [active]
983548008053	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
983548008054	gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521
983548008055	DNA polymerase III subunit beta; Validated; Region: PRK05643
983548008056	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
983548008057	putative DNA binding surface [nucleotide binding]; other site
983548008058	dimer interface [polypeptide binding]; other site
983548008059	beta-clamp/clamp loader binding surface; other site
983548008060	beta-clamp/translesion DNA polymerase binding surface; other site
983548008061	M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA; cd03877
983548008062	Peptidase family M28; Region: Peptidase_M28; pfam04389
983548008063	metal binding site [ion binding]; metal-binding site
983548008064	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
983548008065	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
983548008066	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
983548008067	homodimer interface [polypeptide binding]; other site
983548008068	substrate-cofactor binding pocket; other site
983548008069	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548008070	catalytic residue [active]
983548008071	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
983548008072	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
983548008073	Coenzyme A binding pocket [chemical binding]; other site
983548008074	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
983548008075	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
983548008076	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
983548008077	Predicted membrane protein [Function unknown]; Region: COG4325
983548008078	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
983548008079	transcription elongation factor regulatory protein; Validated; Region: PRK06342
983548008080	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
983548008081	Pirin-related protein [General function prediction only]; Region: COG1741
983548008082	Pirin; Region: Pirin; pfam02678
983548008083	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
983548008084	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548008085	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
983548008086	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
983548008087	putative catalytic site [active]
983548008088	putative metal binding site [ion binding]; other site
983548008089	putative phosphate binding site [ion binding]; other site
983548008090	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
983548008091	putative ligand binding pocket/active site [active]
983548008092	putative metal binding site [ion binding]; other site
983548008093	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548008094	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
983548008095	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
983548008096	active site
983548008097	metal binding site [ion binding]; metal-binding site
983548008098	Surface antigen; Region: Bac_surface_Ag; pfam01103
983548008099	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548008100	Zn2+ binding site [ion binding]; other site
983548008101	Mg2+ binding site [ion binding]; other site
983548008102	GAF domain; Region: GAF; cl17456
983548008103	Domain of unknown function (DUF4369); Region: DUF4369; pfam14289
983548008104	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
983548008105	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
983548008106	catalytic residues [active]
983548008107	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
983548008108	putative catalytic site [active]
983548008109	putative metal binding site [ion binding]; other site
983548008110	putative phosphate binding site [ion binding]; other site
983548008111	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
983548008112	Mechanosensitive ion channel; Region: MS_channel; pfam00924
983548008113	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
983548008114	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
983548008115	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
983548008116	catalytic residue [active]
983548008117	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
983548008118	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
983548008119	dimer interface [polypeptide binding]; other site
983548008120	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548008121	catalytic residue [active]
983548008122	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
983548008123	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
983548008124	hypothetical protein; Provisional; Region: PRK14623
983548008125	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
983548008126	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
983548008127	ligand binding site [chemical binding]; other site
983548008128	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
983548008129	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
983548008130	tetramer interface [polypeptide binding]; other site
983548008131	pyridoxal 5'-phosphate binding site [chemical binding]; other site
983548008132	catalytic residue [active]
983548008133	Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276
983548008134	active site
983548008135	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
983548008136	Domain of unknown function (DUF4252); Region: DUF4252; pfam14060
983548008137	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
983548008138	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
983548008139	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
983548008140	DNA binding residues [nucleotide binding]
983548008141	membrane protein insertase; Provisional; Region: PRK01318
983548008142	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
983548008143	CTP synthetase; Validated; Region: pyrG; PRK05380
983548008144	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
983548008145	Catalytic site [active]
983548008146	active site
983548008147	UTP binding site [chemical binding]; other site
983548008148	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
983548008149	active site
983548008150	putative oxyanion hole; other site
983548008151	catalytic triad [active]
983548008152	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
983548008153	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
983548008154	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
983548008155	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
983548008156	active site
983548008157	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548008158	Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772
983548008159	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
983548008160	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; pfam05090
983548008161	Imelysin; Region: Peptidase_M75; pfam09375
983548008162	Haem-binding domain; Region: Haem_bd; pfam14376
983548008163	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
983548008164	DEAD-like helicases superfamily; Region: DEXDc; smart00487
983548008165	ATP binding site [chemical binding]; other site
983548008166	Mg++ binding site [ion binding]; other site
983548008167	motif III; other site
983548008168	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548008169	nucleotide binding region [chemical binding]; other site
983548008170	ATP-binding site [chemical binding]; other site
983548008171	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
983548008172	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
983548008173	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
983548008174	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
983548008175	active site
983548008176	NTP binding site [chemical binding]; other site
983548008177	metal binding triad [ion binding]; metal-binding site
983548008178	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
983548008179	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
983548008180	Zn2+ binding site [ion binding]; other site
983548008181	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cl17503
983548008182	Mg2+ binding site [ion binding]; other site
983548008183	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
983548008184	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
983548008185	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
983548008186	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
983548008187	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
983548008188	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
983548008189	ATP binding site [chemical binding]; other site
983548008190	Mg++ binding site [ion binding]; other site
983548008191	motif III; other site
983548008192	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
983548008193	nucleotide binding region [chemical binding]; other site
983548008194	ATP-binding site [chemical binding]; other site
983548008195	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
983548008196	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
983548008197	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
983548008198	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
983548008199	Walker A/P-loop; other site
983548008200	ATP binding site [chemical binding]; other site
983548008201	Q-loop/lid; other site
983548008202	ABC transporter signature motif; other site
983548008203	Walker B; other site
983548008204	D-loop; other site
983548008205	H-loop/switch region; other site
983548008206	37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245
983548008207	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
983548008208	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
983548008209	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
983548008210	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
983548008211	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
983548008212	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
983548008213	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
983548008214	Protein of unknown function (DUF2911); Region: DUF2911; pfam11138
983548008215	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
983548008216	putative hydrophobic ligand binding site [chemical binding]; other site
983548008217	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
983548008218	classical (c) SDRs; Region: SDR_c; cd05233
983548008219	NAD(P) binding site [chemical binding]; other site
983548008220	active site
983548008221	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
983548008222	DNA photolyase; Region: DNA_photolyase; pfam00875
983548008223	short chain dehydrogenase; Provisional; Region: PRK12939
983548008224	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
983548008225	NADP binding site [chemical binding]; other site
983548008226	homodimer interface [polypeptide binding]; other site
983548008227	active site
983548008228	substrate binding site [chemical binding]; other site
983548008229	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
983548008230	M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673
983548008231	putative metal binding site [ion binding]; other site
983548008232	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
983548008233	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
983548008234	dimer interface [polypeptide binding]; other site
983548008235	putative metal binding site [ion binding]; other site
983548008236	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
983548008237	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
983548008238	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548008239	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548008240	ABC transporter; Region: ABC_tran_2; pfam12848
983548008241	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
983548008242	Cna protein B-type domain; Region: Cna_B_2; pfam13715
983548008243	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
983548008244	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
983548008245	putative active site [active]
983548008246	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
983548008247	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
983548008248	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
983548008249	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
983548008250	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
983548008251	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
983548008252	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
983548008253	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
983548008254	Uncharacterized conserved protein [Function unknown]; Region: COG1739
983548008255	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
983548008256	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
983548008257	active site