-- dump date 20140619_122115 -- class Genbank::misc_feature -- table misc_feature_note -- id note 562970000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 562970000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 562970000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000004 Walker A motif; other site 562970000005 ATP binding site [chemical binding]; other site 562970000006 Walker B motif; other site 562970000007 arginine finger; other site 562970000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 562970000009 DnaA box-binding interface [nucleotide binding]; other site 562970000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 562970000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 562970000012 putative DNA binding surface [nucleotide binding]; other site 562970000013 dimer interface [polypeptide binding]; other site 562970000014 beta-clamp/clamp loader binding surface; other site 562970000015 beta-clamp/translesion DNA polymerase binding surface; other site 562970000016 S4 domain; Region: S4_2; pfam13275 562970000017 recombination protein F; Reviewed; Region: recF; PRK00064 562970000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 562970000019 Walker A/P-loop; other site 562970000020 ATP binding site [chemical binding]; other site 562970000021 Q-loop/lid; other site 562970000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970000023 ABC transporter signature motif; other site 562970000024 Walker B; other site 562970000025 D-loop; other site 562970000026 H-loop/switch region; other site 562970000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 562970000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970000029 Mg2+ binding site [ion binding]; other site 562970000030 G-X-G motif; other site 562970000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 562970000032 anchoring element; other site 562970000033 dimer interface [polypeptide binding]; other site 562970000034 ATP binding site [chemical binding]; other site 562970000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 562970000036 active site 562970000037 putative metal-binding site [ion binding]; other site 562970000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 562970000039 DNA gyrase subunit A; Validated; Region: PRK05560 562970000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 562970000041 CAP-like domain; other site 562970000042 active site 562970000043 primary dimer interface [polypeptide binding]; other site 562970000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 562970000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 562970000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 562970000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 562970000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 562970000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 562970000050 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 562970000051 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 562970000052 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 562970000053 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 562970000054 active site 562970000055 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 562970000056 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 562970000057 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 562970000058 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 562970000059 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 562970000060 active site 562970000061 multimer interface [polypeptide binding]; other site 562970000062 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 562970000063 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 562970000064 predicted active site [active] 562970000065 catalytic triad [active] 562970000066 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 562970000067 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 562970000068 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 562970000069 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 562970000070 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 562970000071 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 562970000072 active site 562970000073 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 562970000074 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 562970000075 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 562970000076 active site 562970000077 catalytic residues [active] 562970000078 DNA binding site [nucleotide binding] 562970000079 Int/Topo IB signature motif; other site 562970000080 Helix-turn-helix domain; Region: HTH_17; pfam12728 562970000081 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 562970000082 Low-spin heme binding site [chemical binding]; other site 562970000083 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 562970000084 Subunit I/II interface [polypeptide binding]; other site 562970000085 Putative Q-pathway; other site 562970000086 Putative D-pathway homolog; other site 562970000087 Putative alternate electron transfer pathway; other site 562970000088 Putative water exit pathway; other site 562970000089 Binuclear center (active site) [active] 562970000090 Putative K-pathway homolog; other site 562970000091 Putative proton exit pathway; other site 562970000092 Subunit I/IIa interface [polypeptide binding]; other site 562970000093 Electron transfer pathway; other site 562970000094 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 562970000095 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 562970000096 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970000097 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970000098 Peptidase family M23; Region: Peptidase_M23; pfam01551 562970000099 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 562970000100 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 562970000101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 562970000102 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 562970000103 YmaF family; Region: YmaF; pfam12788 562970000104 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 562970000105 nucleoside/Zn binding site; other site 562970000106 dimer interface [polypeptide binding]; other site 562970000107 catalytic motif [active] 562970000108 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 562970000109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970000110 dimer interface [polypeptide binding]; other site 562970000111 phosphorylation site [posttranslational modification] 562970000112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970000113 ATP binding site [chemical binding]; other site 562970000114 G-X-G motif; other site 562970000115 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 562970000116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000117 Walker A motif; other site 562970000118 ATP binding site [chemical binding]; other site 562970000119 Walker B motif; other site 562970000120 arginine finger; other site 562970000121 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 562970000122 hypothetical protein; Validated; Region: PRK00153 562970000123 recombination protein RecR; Reviewed; Region: recR; PRK00076 562970000124 RecR protein; Region: RecR; pfam02132 562970000125 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 562970000126 putative active site [active] 562970000127 putative metal-binding site [ion binding]; other site 562970000128 tetramer interface [polypeptide binding]; other site 562970000129 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 562970000130 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 562970000131 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 562970000132 active site 562970000133 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 562970000134 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 562970000135 dimer interface [polypeptide binding]; other site 562970000136 active site 562970000137 CoA binding pocket [chemical binding]; other site 562970000138 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 562970000139 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 562970000140 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970000141 catalytic residue [active] 562970000142 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 562970000143 thymidylate kinase; Validated; Region: tmk; PRK00698 562970000144 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 562970000145 TMP-binding site; other site 562970000146 ATP-binding site [chemical binding]; other site 562970000147 Protein of unknown function (DUF970); Region: DUF970; pfam06153 562970000148 Protein of unknown function (DUF327); Region: DUF327; pfam03885 562970000149 DNA polymerase III subunit delta'; Validated; Region: PRK08058 562970000150 DNA polymerase III subunit delta'; Validated; Region: PRK08485 562970000151 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 562970000152 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 562970000153 Predicted methyltransferases [General function prediction only]; Region: COG0313 562970000154 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 562970000155 putative SAM binding site [chemical binding]; other site 562970000156 putative homodimer interface [polypeptide binding]; other site 562970000157 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970000158 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 562970000159 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 562970000160 active site 562970000161 HIGH motif; other site 562970000162 KMSKS motif; other site 562970000163 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 562970000164 tRNA binding surface [nucleotide binding]; other site 562970000165 anticodon binding site; other site 562970000166 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 562970000167 dimer interface [polypeptide binding]; other site 562970000168 putative tRNA-binding site [nucleotide binding]; other site 562970000169 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 562970000170 active site 562970000171 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 562970000172 active site 562970000173 metal binding site [ion binding]; metal-binding site 562970000174 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 562970000175 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 562970000176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970000177 S-adenosylmethionine binding site [chemical binding]; other site 562970000178 Protein of unknown function (DUF458); Region: DUF458; pfam04308 562970000179 DHH family; Region: DHH; pfam01368 562970000180 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970000181 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 562970000182 active site 562970000183 YabG peptidase U57; Region: Peptidase_U57; pfam05582 562970000184 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 562970000185 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 562970000186 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 562970000187 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 562970000188 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 562970000189 proposed catalytic triad [active] 562970000190 active site nucleophile [active] 562970000191 cyanophycin synthetase; Provisional; Region: PRK14016 562970000192 ATP-grasp domain; Region: ATP-grasp_4; cl17255 562970000193 ATP-grasp domain; Region: ATP-grasp_4; cl17255 562970000194 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970000195 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 562970000196 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 562970000197 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 562970000198 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 562970000199 active site 562970000200 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 562970000201 pur operon repressor; Provisional; Region: PRK09213 562970000202 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 562970000203 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970000204 active site 562970000205 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 562970000206 homotrimer interaction site [polypeptide binding]; other site 562970000207 putative active site [active] 562970000208 SpoVG; Region: SpoVG; cl00915 562970000209 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 562970000210 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 562970000211 Substrate binding site; other site 562970000212 Mg++ binding site; other site 562970000213 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 562970000214 active site 562970000215 substrate binding site [chemical binding]; other site 562970000216 CoA binding site [chemical binding]; other site 562970000217 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 562970000218 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 562970000219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970000220 active site 562970000221 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 562970000222 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 562970000223 5S rRNA interface [nucleotide binding]; other site 562970000224 CTC domain interface [polypeptide binding]; other site 562970000225 L16 interface [polypeptide binding]; other site 562970000226 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 562970000227 putative active site [active] 562970000228 catalytic residue [active] 562970000229 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 562970000230 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 562970000231 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 562970000232 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970000233 ATP binding site [chemical binding]; other site 562970000234 putative Mg++ binding site [ion binding]; other site 562970000235 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970000236 nucleotide binding region [chemical binding]; other site 562970000237 ATP-binding site [chemical binding]; other site 562970000238 TRCF domain; Region: TRCF; pfam03461 562970000239 SurA N-terminal domain; Region: SurA_N_3; cl07813 562970000240 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 562970000241 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 562970000242 stage V sporulation protein T; Region: spore_V_T; TIGR02851 562970000243 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 562970000244 Transposase domain (DUF772); Region: DUF772; pfam05598 562970000245 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970000246 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970000247 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970000248 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 562970000249 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 562970000250 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 562970000251 homodimer interface [polypeptide binding]; other site 562970000252 metal binding site [ion binding]; metal-binding site 562970000253 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 562970000254 homodimer interface [polypeptide binding]; other site 562970000255 active site 562970000256 putative chemical substrate binding site [chemical binding]; other site 562970000257 metal binding site [ion binding]; metal-binding site 562970000258 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 562970000259 IHF dimer interface [polypeptide binding]; other site 562970000260 IHF - DNA interface [nucleotide binding]; other site 562970000261 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970000262 RNA binding surface [nucleotide binding]; other site 562970000263 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 562970000264 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 562970000265 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 562970000266 O-Antigen ligase; Region: Wzy_C; cl04850 562970000267 sporulation protein YabP; Region: spore_yabP; TIGR02892 562970000268 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 562970000269 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 562970000270 Septum formation initiator; Region: DivIC; pfam04977 562970000271 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 562970000272 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 562970000273 RNA binding site [nucleotide binding]; other site 562970000274 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 562970000275 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 562970000276 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 562970000277 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 562970000278 catalytic motif [active] 562970000279 Zn binding site [ion binding]; other site 562970000280 stage II sporulation protein E; Region: spore_II_E; TIGR02865 562970000281 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 562970000282 Uncharacterized conserved protein [Function unknown]; Region: COG2966 562970000283 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 562970000284 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 562970000285 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 562970000286 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 562970000287 Ligand Binding Site [chemical binding]; other site 562970000288 TilS substrate C-terminal domain; Region: TilS_C; smart00977 562970000289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970000290 active site 562970000291 FtsH Extracellular; Region: FtsH_ext; pfam06480 562970000292 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 562970000293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000294 Walker A motif; other site 562970000295 ATP binding site [chemical binding]; other site 562970000296 Walker B motif; other site 562970000297 arginine finger; other site 562970000298 Peptidase family M41; Region: Peptidase_M41; pfam01434 562970000299 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 562970000300 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970000301 Zn2+ binding site [ion binding]; other site 562970000302 Mg2+ binding site [ion binding]; other site 562970000303 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 562970000304 L-aspartate oxidase; Provisional; Region: PRK06175 562970000305 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 562970000306 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 562970000307 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 562970000308 dimerization interface [polypeptide binding]; other site 562970000309 active site 562970000310 pantothenate kinase; Reviewed; Region: PRK13318 562970000311 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 562970000312 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 562970000313 dimerization interface [polypeptide binding]; other site 562970000314 domain crossover interface; other site 562970000315 redox-dependent activation switch; other site 562970000316 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 562970000317 dihydropteroate synthase; Region: DHPS; TIGR01496 562970000318 substrate binding pocket [chemical binding]; other site 562970000319 dimer interface [polypeptide binding]; other site 562970000320 inhibitor binding site; inhibition site 562970000321 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 562970000322 homooctamer interface [polypeptide binding]; other site 562970000323 active site 562970000324 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 562970000325 catalytic center binding site [active] 562970000326 ATP binding site [chemical binding]; other site 562970000327 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 562970000328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970000329 non-specific DNA binding site [nucleotide binding]; other site 562970000330 salt bridge; other site 562970000331 sequence-specific DNA binding site [nucleotide binding]; other site 562970000332 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 562970000333 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 562970000334 FMN binding site [chemical binding]; other site 562970000335 active site 562970000336 catalytic residues [active] 562970000337 substrate binding site [chemical binding]; other site 562970000338 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 562970000339 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 562970000340 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 562970000341 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 562970000342 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 562970000343 dimer interface [polypeptide binding]; other site 562970000344 putative anticodon binding site; other site 562970000345 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 562970000346 motif 1; other site 562970000347 active site 562970000348 motif 2; other site 562970000349 motif 3; other site 562970000350 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 562970000351 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 562970000352 CoenzymeA binding site [chemical binding]; other site 562970000353 subunit interaction site [polypeptide binding]; other site 562970000354 PHB binding site; other site 562970000355 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970000356 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970000357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 562970000358 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 562970000359 substrate binding pocket [chemical binding]; other site 562970000360 membrane-bound complex binding site; other site 562970000361 hinge residues; other site 562970000362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970000363 dimer interface [polypeptide binding]; other site 562970000364 conserved gate region; other site 562970000365 putative PBP binding loops; other site 562970000366 ABC-ATPase subunit interface; other site 562970000367 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 562970000368 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 562970000369 Walker A/P-loop; other site 562970000370 ATP binding site [chemical binding]; other site 562970000371 Q-loop/lid; other site 562970000372 ABC transporter signature motif; other site 562970000373 Walker B; other site 562970000374 D-loop; other site 562970000375 H-loop/switch region; other site 562970000376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 562970000377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 562970000378 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 562970000379 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 562970000380 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 562970000381 UvrB/uvrC motif; Region: UVR; pfam02151 562970000382 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 562970000383 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 562970000384 ADP binding site [chemical binding]; other site 562970000385 phosphagen binding site; other site 562970000386 substrate specificity loop; other site 562970000387 Clp protease ATP binding subunit; Region: clpC; CHL00095 562970000388 Clp amino terminal domain; Region: Clp_N; pfam02861 562970000389 Clp amino terminal domain; Region: Clp_N; pfam02861 562970000390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000391 Walker A motif; other site 562970000392 ATP binding site [chemical binding]; other site 562970000393 Walker B motif; other site 562970000394 arginine finger; other site 562970000395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000396 Walker A motif; other site 562970000397 ATP binding site [chemical binding]; other site 562970000398 Walker B motif; other site 562970000399 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 562970000400 DNA repair protein RadA; Provisional; Region: PRK11823 562970000401 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 562970000402 Walker A motif; other site 562970000403 ATP binding site [chemical binding]; other site 562970000404 Walker B motif; other site 562970000405 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 562970000406 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 562970000407 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 562970000408 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 562970000409 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 562970000410 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 562970000411 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 562970000412 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 562970000413 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 562970000414 putative active site [active] 562970000415 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 562970000416 substrate binding site; other site 562970000417 dimer interface; other site 562970000418 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 562970000419 homotrimer interaction site [polypeptide binding]; other site 562970000420 zinc binding site [ion binding]; other site 562970000421 CDP-binding sites; other site 562970000422 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 562970000423 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 562970000424 active site 562970000425 HIGH motif; other site 562970000426 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 562970000427 active site 562970000428 KMSKS motif; other site 562970000429 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 562970000430 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 562970000431 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 562970000432 trimer interface [polypeptide binding]; other site 562970000433 active site 562970000434 substrate binding site [chemical binding]; other site 562970000435 CoA binding site [chemical binding]; other site 562970000436 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 562970000437 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 562970000438 active site 562970000439 HIGH motif; other site 562970000440 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 562970000441 KMSKS motif; other site 562970000442 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 562970000443 tRNA binding surface [nucleotide binding]; other site 562970000444 anticodon binding site; other site 562970000445 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 562970000446 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 562970000447 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 562970000448 YacP-like NYN domain; Region: NYN_YacP; pfam05991 562970000449 RNA polymerase factor sigma-70; Validated; Region: PRK08295 562970000450 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970000451 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 562970000452 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970000453 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970000454 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 562970000455 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 562970000456 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 562970000457 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 562970000458 putative homodimer interface [polypeptide binding]; other site 562970000459 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 562970000460 heterodimer interface [polypeptide binding]; other site 562970000461 homodimer interface [polypeptide binding]; other site 562970000462 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 562970000463 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 562970000464 23S rRNA interface [nucleotide binding]; other site 562970000465 L7/L12 interface [polypeptide binding]; other site 562970000466 putative thiostrepton binding site; other site 562970000467 L25 interface [polypeptide binding]; other site 562970000468 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 562970000469 mRNA/rRNA interface [nucleotide binding]; other site 562970000470 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 562970000471 23S rRNA interface [nucleotide binding]; other site 562970000472 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 562970000473 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 562970000474 core dimer interface [polypeptide binding]; other site 562970000475 peripheral dimer interface [polypeptide binding]; other site 562970000476 L10 interface [polypeptide binding]; other site 562970000477 L11 interface [polypeptide binding]; other site 562970000478 putative EF-Tu interaction site [polypeptide binding]; other site 562970000479 putative EF-G interaction site [polypeptide binding]; other site 562970000480 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 562970000481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970000482 S-adenosylmethionine binding site [chemical binding]; other site 562970000483 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 562970000484 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 562970000485 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 562970000486 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 562970000487 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 562970000488 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 562970000489 RPB12 interaction site [polypeptide binding]; other site 562970000490 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 562970000491 RPB10 interaction site [polypeptide binding]; other site 562970000492 RPB1 interaction site [polypeptide binding]; other site 562970000493 RPB11 interaction site [polypeptide binding]; other site 562970000494 RPB3 interaction site [polypeptide binding]; other site 562970000495 RPB12 interaction site [polypeptide binding]; other site 562970000496 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 562970000497 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 562970000498 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 562970000499 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 562970000500 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 562970000501 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 562970000502 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 562970000503 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 562970000504 G-loop; other site 562970000505 DNA binding site [nucleotide binding] 562970000506 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 562970000507 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 562970000508 S17 interaction site [polypeptide binding]; other site 562970000509 S8 interaction site; other site 562970000510 16S rRNA interaction site [nucleotide binding]; other site 562970000511 streptomycin interaction site [chemical binding]; other site 562970000512 23S rRNA interaction site [nucleotide binding]; other site 562970000513 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 562970000514 30S ribosomal protein S7; Validated; Region: PRK05302 562970000515 elongation factor G; Reviewed; Region: PRK00007 562970000516 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 562970000517 G1 box; other site 562970000518 putative GEF interaction site [polypeptide binding]; other site 562970000519 GTP/Mg2+ binding site [chemical binding]; other site 562970000520 Switch I region; other site 562970000521 G2 box; other site 562970000522 G3 box; other site 562970000523 Switch II region; other site 562970000524 G4 box; other site 562970000525 G5 box; other site 562970000526 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 562970000527 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 562970000528 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 562970000529 elongation factor Tu; Reviewed; Region: PRK00049 562970000530 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 562970000531 G1 box; other site 562970000532 GEF interaction site [polypeptide binding]; other site 562970000533 GTP/Mg2+ binding site [chemical binding]; other site 562970000534 Switch I region; other site 562970000535 G2 box; other site 562970000536 G3 box; other site 562970000537 Switch II region; other site 562970000538 G4 box; other site 562970000539 G5 box; other site 562970000540 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 562970000541 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 562970000542 Antibiotic Binding Site [chemical binding]; other site 562970000543 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 562970000544 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 562970000545 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 562970000546 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 562970000547 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 562970000548 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 562970000549 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 562970000550 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 562970000551 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 562970000552 putative translocon binding site; other site 562970000553 protein-rRNA interface [nucleotide binding]; other site 562970000554 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 562970000555 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 562970000556 G-X-X-G motif; other site 562970000557 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 562970000558 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 562970000559 23S rRNA interface [nucleotide binding]; other site 562970000560 5S rRNA interface [nucleotide binding]; other site 562970000561 putative antibiotic binding site [chemical binding]; other site 562970000562 L25 interface [polypeptide binding]; other site 562970000563 L27 interface [polypeptide binding]; other site 562970000564 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 562970000565 23S rRNA interface [nucleotide binding]; other site 562970000566 putative translocon interaction site; other site 562970000567 signal recognition particle (SRP54) interaction site; other site 562970000568 L23 interface [polypeptide binding]; other site 562970000569 trigger factor interaction site; other site 562970000570 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 562970000571 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 562970000572 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 562970000573 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 562970000574 RNA binding site [nucleotide binding]; other site 562970000575 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 562970000576 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 562970000577 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 562970000578 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 562970000579 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 562970000580 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 562970000581 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 562970000582 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 562970000583 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 562970000584 5S rRNA interface [nucleotide binding]; other site 562970000585 L27 interface [polypeptide binding]; other site 562970000586 23S rRNA interface [nucleotide binding]; other site 562970000587 L5 interface [polypeptide binding]; other site 562970000588 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 562970000589 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 562970000590 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 562970000591 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 562970000592 23S rRNA binding site [nucleotide binding]; other site 562970000593 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 562970000594 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 562970000595 SecY translocase; Region: SecY; pfam00344 562970000596 adenylate kinase; Reviewed; Region: adk; PRK00279 562970000597 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 562970000598 AMP-binding site [chemical binding]; other site 562970000599 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 562970000600 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 562970000601 active site 562970000602 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 562970000603 RNA binding site [nucleotide binding]; other site 562970000604 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 562970000605 rRNA binding site [nucleotide binding]; other site 562970000606 predicted 30S ribosome binding site; other site 562970000607 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 562970000608 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 562970000609 30S ribosomal protein S13; Region: bact_S13; TIGR03631 562970000610 30S ribosomal protein S11; Validated; Region: PRK05309 562970000611 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 562970000612 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 562970000613 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970000614 RNA binding surface [nucleotide binding]; other site 562970000615 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 562970000616 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 562970000617 alphaNTD homodimer interface [polypeptide binding]; other site 562970000618 alphaNTD - beta interaction site [polypeptide binding]; other site 562970000619 alphaNTD - beta' interaction site [polypeptide binding]; other site 562970000620 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 562970000621 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 562970000622 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 562970000623 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 562970000624 active site 562970000625 dimerization interface 3.5A [polypeptide binding]; other site 562970000626 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 562970000627 23S rRNA interface [nucleotide binding]; other site 562970000628 L3 interface [polypeptide binding]; other site 562970000629 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 562970000630 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 562970000631 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 562970000632 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 562970000633 Walker A motif; other site 562970000634 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 562970000635 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 562970000636 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 562970000637 Integral membrane protein DUF95; Region: DUF95; pfam01944 562970000638 Arginase family; Region: Arginase; cd09989 562970000639 agmatinase; Region: agmatinase; TIGR01230 562970000640 active site 562970000641 Mn binding site [ion binding]; other site 562970000642 oligomer interface [polypeptide binding]; other site 562970000643 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 562970000644 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 562970000645 Active Sites [active] 562970000646 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 562970000647 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 562970000648 ATP-sulfurylase; Region: ATPS; cd00517 562970000649 active site 562970000650 HXXH motif; other site 562970000651 flexible loop; other site 562970000652 TIGR00159 family protein; Region: TIGR00159 562970000653 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 562970000654 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 562970000655 YbbR-like protein; Region: YbbR; pfam07949 562970000656 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 562970000657 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 562970000658 active site 562970000659 substrate binding site [chemical binding]; other site 562970000660 metal binding site [ion binding]; metal-binding site 562970000661 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 562970000662 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 562970000663 glutaminase active site [active] 562970000664 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 562970000665 dimer interface [polypeptide binding]; other site 562970000666 active site 562970000667 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 562970000668 dimer interface [polypeptide binding]; other site 562970000669 active site 562970000670 AzlC protein; Region: AzlC; pfam03591 562970000671 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 562970000672 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 562970000673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970000674 non-specific DNA binding site [nucleotide binding]; other site 562970000675 salt bridge; other site 562970000676 sequence-specific DNA binding site [nucleotide binding]; other site 562970000677 Cupin domain; Region: Cupin_2; pfam07883 562970000678 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 562970000679 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 562970000680 putative dimer interface [polypeptide binding]; other site 562970000681 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970000682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970000683 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970000684 Transcriptional regulator [Transcription]; Region: LytR; COG1316 562970000685 Bacterial SH3 domain; Region: SH3_3; pfam08239 562970000686 YwiC-like protein; Region: YwiC; pfam14256 562970000687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 562970000688 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 562970000689 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 562970000690 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 562970000691 putative substrate binding site [chemical binding]; other site 562970000692 putative ATP binding site [chemical binding]; other site 562970000693 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 562970000694 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 562970000695 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 562970000696 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 562970000697 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 562970000698 PemK-like protein; Region: PemK; pfam02452 562970000699 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 562970000700 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 562970000701 homotetramer interface [polypeptide binding]; other site 562970000702 ligand binding site [chemical binding]; other site 562970000703 catalytic site [active] 562970000704 NAD binding site [chemical binding]; other site 562970000705 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 562970000706 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 562970000707 catalytic triad [active] 562970000708 Protein of unknown function (DUF1659); Region: DUF1659; pfam07872 562970000709 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 562970000710 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 562970000711 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 562970000712 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 562970000713 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 562970000714 EamA-like transporter family; Region: EamA; pfam00892 562970000715 EamA-like transporter family; Region: EamA; pfam00892 562970000716 thiamine monophosphate kinase; Provisional; Region: PRK05731 562970000717 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 562970000718 ATP binding site [chemical binding]; other site 562970000719 dimerization interface [polypeptide binding]; other site 562970000720 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 562970000721 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 562970000722 Glycoprotease family; Region: Peptidase_M22; pfam00814 562970000723 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 562970000724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 562970000725 Coenzyme A binding pocket [chemical binding]; other site 562970000726 UGMP family protein; Validated; Region: PRK09604 562970000727 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 562970000728 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 562970000729 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 562970000730 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 562970000731 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 562970000732 oligomerisation interface [polypeptide binding]; other site 562970000733 mobile loop; other site 562970000734 roof hairpin; other site 562970000735 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 562970000736 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 562970000737 ring oligomerisation interface [polypeptide binding]; other site 562970000738 ATP/Mg binding site [chemical binding]; other site 562970000739 stacking interactions; other site 562970000740 hinge regions; other site 562970000741 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 562970000742 CoenzymeA binding site [chemical binding]; other site 562970000743 subunit interaction site [polypeptide binding]; other site 562970000744 PHB binding site; other site 562970000745 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 562970000746 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970000747 dimerization interface [polypeptide binding]; other site 562970000748 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970000749 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970000750 dimer interface [polypeptide binding]; other site 562970000751 putative CheW interface [polypeptide binding]; other site 562970000752 cobalt transport protein CbiM; Validated; Region: PRK08319 562970000753 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 562970000754 cobalt transport protein CbiN; Provisional; Region: PRK02898 562970000755 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 562970000756 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 562970000757 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 562970000758 Walker A/P-loop; other site 562970000759 ATP binding site [chemical binding]; other site 562970000760 Q-loop/lid; other site 562970000761 ABC transporter signature motif; other site 562970000762 Walker B; other site 562970000763 D-loop; other site 562970000764 H-loop/switch region; other site 562970000765 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 562970000766 putative FMN binding site [chemical binding]; other site 562970000767 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970000768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970000769 dimerization interface [polypeptide binding]; other site 562970000770 putative DNA binding site [nucleotide binding]; other site 562970000771 putative Zn2+ binding site [ion binding]; other site 562970000772 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 562970000773 Predicted integral membrane protein [Function unknown]; Region: COG5658 562970000774 SdpI/YhfL protein family; Region: SdpI; pfam13630 562970000775 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970000776 DNA-binding site [nucleotide binding]; DNA binding site 562970000777 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 562970000778 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970000779 Walker A/P-loop; other site 562970000780 ATP binding site [chemical binding]; other site 562970000781 Q-loop/lid; other site 562970000782 ABC transporter signature motif; other site 562970000783 Walker B; other site 562970000784 D-loop; other site 562970000785 H-loop/switch region; other site 562970000786 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970000787 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 562970000788 Walker A/P-loop; other site 562970000789 ATP binding site [chemical binding]; other site 562970000790 Q-loop/lid; other site 562970000791 ABC transporter signature motif; other site 562970000792 Walker B; other site 562970000793 D-loop; other site 562970000794 H-loop/switch region; other site 562970000795 branched-chain amino acid aminotransferase; Validated; Region: PRK06606 562970000796 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 562970000797 homodimer interface [polypeptide binding]; other site 562970000798 substrate-cofactor binding pocket; other site 562970000799 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970000800 catalytic residue [active] 562970000801 Phosphoesterase family; Region: Phosphoesterase; pfam04185 562970000802 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 562970000803 Cupin domain; Region: Cupin_2; pfam07883 562970000804 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 562970000805 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 562970000806 active site 562970000807 catalytic tetrad [active] 562970000808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 562970000809 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 562970000810 Peptidase family M23; Region: Peptidase_M23; pfam01551 562970000811 MoxR-like ATPases [General function prediction only]; Region: COG0714 562970000812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000813 Walker A motif; other site 562970000814 ATP binding site [chemical binding]; other site 562970000815 Walker B motif; other site 562970000816 arginine finger; other site 562970000817 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 562970000818 Protein of unknown function DUF58; Region: DUF58; pfam01882 562970000819 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 562970000820 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 562970000821 GMP synthase; Reviewed; Region: guaA; PRK00074 562970000822 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 562970000823 AMP/PPi binding site [chemical binding]; other site 562970000824 candidate oxyanion hole; other site 562970000825 catalytic triad [active] 562970000826 potential glutamine specificity residues [chemical binding]; other site 562970000827 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 562970000828 ATP Binding subdomain [chemical binding]; other site 562970000829 Ligand Binding sites [chemical binding]; other site 562970000830 Dimerization subdomain; other site 562970000831 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 562970000832 hypothetical protein; Validated; Region: PRK07668 562970000833 PAS domain; Region: PAS_9; pfam13426 562970000834 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970000835 putative active site [active] 562970000836 heme pocket [chemical binding]; other site 562970000837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000838 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970000839 Walker A motif; other site 562970000840 ATP binding site [chemical binding]; other site 562970000841 Walker B motif; other site 562970000842 arginine finger; other site 562970000843 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 562970000844 agmatinase; Region: agmatinase; TIGR01230 562970000845 oligomer interface [polypeptide binding]; other site 562970000846 putative active site [active] 562970000847 Mn binding site [ion binding]; other site 562970000848 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 562970000849 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 562970000850 Na binding site [ion binding]; other site 562970000851 Predicted amidohydrolase [General function prediction only]; Region: COG0388 562970000852 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 562970000853 active site 562970000854 catalytic triad [active] 562970000855 dimer interface [polypeptide binding]; other site 562970000856 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 562970000857 Cytochrome c [Energy production and conversion]; Region: COG3258 562970000858 Cytochrome c; Region: Cytochrom_C; pfam00034 562970000859 Cytochrome c [Energy production and conversion]; Region: COG3258 562970000860 Cytochrome c; Region: Cytochrom_C; pfam00034 562970000861 Predicted transcriptional regulator [Transcription]; Region: COG2378 562970000862 HTH domain; Region: HTH_11; pfam08279 562970000863 WYL domain; Region: WYL; pfam13280 562970000864 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 562970000865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970000866 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970000867 DNA binding residues [nucleotide binding] 562970000868 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970000869 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970000870 DNA binding residues [nucleotide binding] 562970000871 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970000872 catalytic residues [active] 562970000873 catalytic nucleophile [active] 562970000874 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 562970000875 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970000876 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970000877 AAA domain; Region: AAA_21; pfam13304 562970000878 Walker A/P-loop; other site 562970000879 ATP binding site [chemical binding]; other site 562970000880 ABC transporter; Region: ABC_tran; pfam00005 562970000881 Q-loop/lid; other site 562970000882 ABC transporter signature motif; other site 562970000883 Walker B; other site 562970000884 D-loop; other site 562970000885 H-loop/switch region; other site 562970000886 leucyl-tRNA synthetase, archaeal and cytosolic family; Region: leuS_arch; TIGR00395 562970000887 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 562970000888 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 562970000889 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 562970000890 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 562970000891 PYR/PP interface [polypeptide binding]; other site 562970000892 dimer interface [polypeptide binding]; other site 562970000893 TPP binding site [chemical binding]; other site 562970000894 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 562970000895 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 562970000896 TPP-binding site [chemical binding]; other site 562970000897 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 562970000898 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 562970000899 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 562970000900 GAF domain; Region: GAF; cl17456 562970000901 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 562970000902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970000903 putative active site [active] 562970000904 heme pocket [chemical binding]; other site 562970000905 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970000906 dimer interface [polypeptide binding]; other site 562970000907 phosphorylation site [posttranslational modification] 562970000908 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970000909 ATP binding site [chemical binding]; other site 562970000910 Mg2+ binding site [ion binding]; other site 562970000911 G-X-G motif; other site 562970000912 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 562970000913 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 562970000914 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970000915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970000916 active site 562970000917 phosphorylation site [posttranslational modification] 562970000918 intermolecular recognition site; other site 562970000919 dimerization interface [polypeptide binding]; other site 562970000920 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970000921 DNA binding site [nucleotide binding] 562970000922 sensor protein BasS/PmrB; Provisional; Region: PRK10755 562970000923 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970000924 dimerization interface [polypeptide binding]; other site 562970000925 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970000926 dimer interface [polypeptide binding]; other site 562970000927 phosphorylation site [posttranslational modification] 562970000928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970000929 ATP binding site [chemical binding]; other site 562970000930 Mg2+ binding site [ion binding]; other site 562970000931 G-X-G motif; other site 562970000932 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 562970000933 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 562970000934 Multicopper oxidase; Region: Cu-oxidase; pfam00394 562970000935 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 562970000936 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 562970000937 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 562970000938 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 562970000939 putative active site [active] 562970000940 putative substrate binding site [chemical binding]; other site 562970000941 putative cosubstrate binding site; other site 562970000942 catalytic site [active] 562970000943 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 562970000944 active site 562970000945 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 562970000946 dimer interface [polypeptide binding]; other site 562970000947 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 562970000948 Ligand Binding Site [chemical binding]; other site 562970000949 Molecular Tunnel; other site 562970000950 CCC1; Region: CCC1; cd02435 562970000951 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 562970000952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970000953 catalytic residue [active] 562970000954 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 562970000955 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970000956 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 562970000957 PAS domain; Region: PAS; smart00091 562970000958 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 562970000959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970000960 putative active site [active] 562970000961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970000962 Walker A motif; other site 562970000963 ATP binding site [chemical binding]; other site 562970000964 Walker B motif; other site 562970000965 arginine finger; other site 562970000966 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 562970000967 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK06111 562970000968 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970000969 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 562970000970 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 562970000971 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 562970000972 carboxyltransferase (CT) interaction site; other site 562970000973 biotinylation site [posttranslational modification]; other site 562970000974 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970000975 enoyl-CoA hydratase; Provisional; Region: PRK07657 562970000976 substrate binding site [chemical binding]; other site 562970000977 oxyanion hole (OAH) forming residues; other site 562970000978 trimer interface [polypeptide binding]; other site 562970000979 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970000980 dimerization interface [polypeptide binding]; other site 562970000981 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970000982 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970000983 dimer interface [polypeptide binding]; other site 562970000984 putative CheW interface [polypeptide binding]; other site 562970000985 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 562970000986 Domain of unknown function DUF21; Region: DUF21; pfam01595 562970000987 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 562970000988 Transporter associated domain; Region: CorC_HlyC; smart01091 562970000989 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 562970000990 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 562970000991 catalytic residues [active] 562970000992 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 562970000993 metal binding site [ion binding]; metal-binding site 562970000994 active site 562970000995 I-site; other site 562970000996 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970000997 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 562970000998 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 562970000999 active site 562970001000 catalytic triad [active] 562970001001 intracellular protease, PfpI family; Region: PfpI; TIGR01382 562970001002 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 562970001003 conserved cys residue [active] 562970001004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970001005 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 562970001006 active site 562970001007 motif I; other site 562970001008 motif II; other site 562970001009 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 562970001010 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 562970001011 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 562970001012 TPP-binding site [chemical binding]; other site 562970001013 heterodimer interface [polypeptide binding]; other site 562970001014 tetramer interface [polypeptide binding]; other site 562970001015 phosphorylation loop region [posttranslational modification] 562970001016 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 562970001017 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 562970001018 alpha subunit interface [polypeptide binding]; other site 562970001019 TPP binding site [chemical binding]; other site 562970001020 heterodimer interface [polypeptide binding]; other site 562970001021 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970001022 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 562970001023 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 562970001024 E3 interaction surface; other site 562970001025 lipoyl attachment site [posttranslational modification]; other site 562970001026 e3 binding domain; Region: E3_binding; pfam02817 562970001027 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 562970001028 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 562970001029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 562970001030 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970001031 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 562970001032 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 562970001033 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970001034 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970001035 acyl-activating enzyme (AAE) consensus motif; other site 562970001036 AMP binding site [chemical binding]; other site 562970001037 active site 562970001038 CoA binding site [chemical binding]; other site 562970001039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970001040 PAS domain; Region: PAS_9; pfam13426 562970001041 putative active site [active] 562970001042 heme pocket [chemical binding]; other site 562970001043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970001044 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 562970001045 Walker A motif; other site 562970001046 ATP binding site [chemical binding]; other site 562970001047 Walker B motif; other site 562970001048 arginine finger; other site 562970001049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001050 metabolite-proton symporter; Region: 2A0106; TIGR00883 562970001051 putative substrate translocation pore; other site 562970001052 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 562970001053 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 562970001054 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 562970001055 catalytic residue [active] 562970001056 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 562970001057 active site residue [active] 562970001058 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 562970001059 putative homodimer interface [polypeptide binding]; other site 562970001060 putative homotetramer interface [polypeptide binding]; other site 562970001061 putative metal binding site [ion binding]; other site 562970001062 putative homodimer-homodimer interface [polypeptide binding]; other site 562970001063 putative allosteric switch controlling residues; other site 562970001064 Domain of unknown function DUF302; Region: DUF302; cl01364 562970001065 Methyltransferase domain; Region: Methyltransf_23; pfam13489 562970001066 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970001067 S-adenosylmethionine binding site [chemical binding]; other site 562970001068 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 562970001069 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 562970001070 catalytic residues [active] 562970001071 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 562970001072 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 562970001073 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 562970001074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 562970001075 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 562970001076 TAP-like protein; Region: Abhydrolase_4; pfam08386 562970001077 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 562970001078 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 562970001079 transmembrane helices; other site 562970001080 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 562970001081 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 562970001082 transmembrane helices; other site 562970001083 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 562970001084 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 562970001085 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 562970001086 substrate binding pocket [chemical binding]; other site 562970001087 dimer interface [polypeptide binding]; other site 562970001088 inhibitor binding site; inhibition site 562970001089 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 562970001090 B12 binding site [chemical binding]; other site 562970001091 cobalt ligand [ion binding]; other site 562970001092 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 562970001093 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 562970001094 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 562970001095 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 562970001096 UbiA prenyltransferase family; Region: UbiA; pfam01040 562970001097 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 562970001098 Bacterial SH3 domain; Region: SH3_3; pfam08239 562970001099 Bacterial SH3 domain; Region: SH3_3; pfam08239 562970001100 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 562970001101 active site 562970001102 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 562970001103 catalytic tetrad [active] 562970001104 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 562970001105 active site 562970001106 metal binding site [ion binding]; metal-binding site 562970001107 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 562970001108 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 562970001109 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 562970001110 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 562970001111 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 562970001112 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 562970001113 putative NAD(P) binding site [chemical binding]; other site 562970001114 catalytic Zn binding site [ion binding]; other site 562970001115 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 562970001116 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 562970001117 active site 562970001118 catalytic tetrad [active] 562970001119 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970001120 putative active site [active] 562970001121 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 562970001122 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 562970001123 putative ADP-binding pocket [chemical binding]; other site 562970001124 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 562970001125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970001126 DNA-binding site [nucleotide binding]; DNA binding site 562970001127 TrkA-C domain; Region: TrkA_C; pfam02080 562970001128 nodulation ABC transporter NodI; Provisional; Region: PRK13537 562970001129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970001130 Walker A/P-loop; other site 562970001131 ATP binding site [chemical binding]; other site 562970001132 Q-loop/lid; other site 562970001133 ABC transporter signature motif; other site 562970001134 Walker B; other site 562970001135 D-loop; other site 562970001136 H-loop/switch region; other site 562970001137 ABC-2 type transporter; Region: ABC2_membrane; cl17235 562970001138 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 562970001139 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 562970001140 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970001141 motif II; other site 562970001142 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 562970001143 active site 562970001144 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 562970001145 ThiC-associated domain; Region: ThiC-associated; pfam13667 562970001146 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 562970001147 Transposase domain (DUF772); Region: DUF772; pfam05598 562970001148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970001149 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970001150 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970001151 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 562970001152 CoA-transferase family III; Region: CoA_transf_3; pfam02515 562970001153 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970001154 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970001155 active site 562970001156 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 562970001157 active site residue [active] 562970001158 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 562970001159 CopC domain; Region: CopC; pfam04234 562970001160 Copper resistance protein D; Region: CopD; cl00563 562970001161 YtkA-like; Region: YtkA; pfam13115 562970001162 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970001163 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 562970001164 catalytic residues [active] 562970001165 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 562970001166 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 562970001167 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 562970001168 dimer interface [polypeptide binding]; other site 562970001169 decamer (pentamer of dimers) interface [polypeptide binding]; other site 562970001170 catalytic triad [active] 562970001171 peroxidatic and resolving cysteines [active] 562970001172 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 562970001173 PAS domain; Region: PAS_9; pfam13426 562970001174 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970001175 putative active site [active] 562970001176 heme pocket [chemical binding]; other site 562970001177 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 562970001178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970001179 Walker A motif; other site 562970001180 ATP binding site [chemical binding]; other site 562970001181 Walker B motif; other site 562970001182 arginine finger; other site 562970001183 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 562970001184 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 562970001185 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 562970001186 carboxyltransferase (CT) interaction site; other site 562970001187 biotinylation site [posttranslational modification]; other site 562970001188 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 562970001189 putative active site [active] 562970001190 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 562970001191 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 562970001192 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 562970001193 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 562970001194 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970001195 inhibitor-cofactor binding pocket; inhibition site 562970001196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970001197 catalytic residue [active] 562970001198 succinic semialdehyde dehydrogenase; Region: PLN02278 562970001199 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 562970001200 tetramerization interface [polypeptide binding]; other site 562970001201 NAD(P) binding site [chemical binding]; other site 562970001202 catalytic residues [active] 562970001203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 562970001204 active site 2 [active] 562970001205 active site 1 [active] 562970001206 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 562970001207 active site 562970001208 catalytic site [active] 562970001209 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 562970001210 Uncharacterized conserved protein [Function unknown]; Region: COG1284 562970001211 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 562970001212 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 562970001213 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 562970001214 Predicted transcriptional regulators [Transcription]; Region: COG1725 562970001215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970001216 DNA-binding site [nucleotide binding]; DNA binding site 562970001217 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 562970001218 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970001219 Walker A/P-loop; other site 562970001220 ATP binding site [chemical binding]; other site 562970001221 Q-loop/lid; other site 562970001222 ABC transporter signature motif; other site 562970001223 Walker B; other site 562970001224 D-loop; other site 562970001225 H-loop/switch region; other site 562970001226 YceG-like family; Region: YceG; pfam02618 562970001227 putative uracil/xanthine transporter; Provisional; Region: PRK11412 562970001228 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 562970001229 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 562970001230 active site 562970001231 catalytic site [active] 562970001232 metal binding site [ion binding]; metal-binding site 562970001233 dimer interface [polypeptide binding]; other site 562970001234 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 562970001235 ABC1 family; Region: ABC1; pfam03109 562970001236 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 562970001237 active site 562970001238 ATP binding site [chemical binding]; other site 562970001239 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 562970001240 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 562970001241 dimerization interface [polypeptide binding]; other site 562970001242 ligand binding site [chemical binding]; other site 562970001243 NADP binding site [chemical binding]; other site 562970001244 catalytic site [active] 562970001245 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 562970001246 putative active site [active] 562970001247 homotetrameric interface [polypeptide binding]; other site 562970001248 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 562970001249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 562970001250 Transposase; Region: HTH_Tnp_1; pfam01527 562970001251 putative transposase OrfB; Reviewed; Region: PHA02517 562970001252 HTH-like domain; Region: HTH_21; pfam13276 562970001253 Integrase core domain; Region: rve; pfam00665 562970001254 Integrase core domain; Region: rve_3; pfam13683 562970001255 DNA methylase; Region: N6_N4_Mtase; cl17433 562970001256 DNA methylase; Region: N6_N4_Mtase; cl17433 562970001257 PglZ domain; Region: PglZ; pfam08665 562970001258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001259 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970001260 putative substrate translocation pore; other site 562970001261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001262 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 562970001263 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 562970001264 catalytic residues [active] 562970001265 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 562970001266 active site 562970001267 zinc binding site [ion binding]; other site 562970001268 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 562970001269 synthetase active site [active] 562970001270 NTP binding site [chemical binding]; other site 562970001271 metal binding site [ion binding]; metal-binding site 562970001272 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 562970001273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970001274 Radical SAM superfamily; Region: Radical_SAM; pfam04055 562970001275 FeS/SAM binding site; other site 562970001276 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 562970001277 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 562970001278 cobalt-precorrin-6x reductase; Reviewed; Region: PRK08057 562970001279 Precorrin-8X methylmutase; Region: CbiC; pfam02570 562970001280 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 562970001281 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 562970001282 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 562970001283 active site 562970001284 putative homodimer interface [polypeptide binding]; other site 562970001285 SAM binding site [chemical binding]; other site 562970001286 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 562970001287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970001288 S-adenosylmethionine binding site [chemical binding]; other site 562970001289 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 562970001290 active site 562970001291 SAM binding site [chemical binding]; other site 562970001292 homodimer interface [polypeptide binding]; other site 562970001293 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 562970001294 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 562970001295 active site 562970001296 SAM binding site [chemical binding]; other site 562970001297 homodimer interface [polypeptide binding]; other site 562970001298 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 562970001299 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 562970001300 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 562970001301 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 562970001302 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 562970001303 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 562970001304 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 562970001305 catalytic triad [active] 562970001306 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 562970001307 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 562970001308 putative active site [active] 562970001309 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 562970001310 putative active site [active] 562970001311 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 562970001312 active site 562970001313 SAM binding site [chemical binding]; other site 562970001314 homodimer interface [polypeptide binding]; other site 562970001315 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 562970001316 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 562970001317 putative dimer interface [polypeptide binding]; other site 562970001318 active site pocket [active] 562970001319 putative cataytic base [active] 562970001320 cobyric acid synthase; Provisional; Region: PRK00784 562970001321 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970001322 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970001323 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 562970001324 catalytic triad [active] 562970001325 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 562970001326 Cobinamide kinase / cobinamide phosphate guanyltransferase; Region: CobU; cl17363 562970001327 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 562970001328 cobalamin synthase; Reviewed; Region: cobS; PRK00235 562970001329 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 562970001330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 562970001331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970001332 homodimer interface [polypeptide binding]; other site 562970001333 catalytic residue [active] 562970001334 Isochorismatase family; Region: Isochorismatase; pfam00857 562970001335 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 562970001336 catalytic triad [active] 562970001337 conserved cis-peptide bond; other site 562970001338 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 562970001339 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13648 562970001340 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 562970001341 Walker A/P-loop; other site 562970001342 ATP binding site [chemical binding]; other site 562970001343 Q-loop/lid; other site 562970001344 ABC transporter signature motif; other site 562970001345 Walker B; other site 562970001346 D-loop; other site 562970001347 H-loop/switch region; other site 562970001348 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 562970001349 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 562970001350 Walker A/P-loop; other site 562970001351 ATP binding site [chemical binding]; other site 562970001352 Q-loop/lid; other site 562970001353 ABC transporter signature motif; other site 562970001354 Walker B; other site 562970001355 D-loop; other site 562970001356 H-loop/switch region; other site 562970001357 BioY family; Region: BioY; pfam02632 562970001358 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 562970001359 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 562970001360 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 562970001361 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 562970001362 Putative D-pathway homolog; other site 562970001363 Low-spin heme binding site [chemical binding]; other site 562970001364 Subunit I/II interface [polypeptide binding]; other site 562970001365 Putative Q-pathway; other site 562970001366 Putative alternate electron transfer pathway; other site 562970001367 Putative water exit pathway; other site 562970001368 Binuclear center (active site) [active] 562970001369 Putative K-pathway homolog; other site 562970001370 Putative proton exit pathway; other site 562970001371 Subunit I/IIa interface [polypeptide binding]; other site 562970001372 Electron transfer pathway; other site 562970001373 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 562970001374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 562970001375 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 562970001376 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 562970001377 Ligand binding site [chemical binding]; other site 562970001378 Electron transfer flavoprotein domain; Region: ETF; pfam01012 562970001379 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 562970001380 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 562970001381 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 562970001382 spermidine synthase; Provisional; Region: PRK00811 562970001383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970001384 drug efflux system protein MdtG; Provisional; Region: PRK09874 562970001385 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 562970001386 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 562970001387 Cytochrome c; Region: Cytochrom_C; pfam00034 562970001388 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 562970001389 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 562970001390 D-pathway; other site 562970001391 Putative ubiquinol binding site [chemical binding]; other site 562970001392 Low-spin heme (heme b) binding site [chemical binding]; other site 562970001393 Putative water exit pathway; other site 562970001394 Binuclear center (heme o3/CuB) [ion binding]; other site 562970001395 K-pathway; other site 562970001396 Putative proton exit pathway; other site 562970001397 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 562970001398 Subunit I/III interface [polypeptide binding]; other site 562970001399 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 562970001400 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 562970001401 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 562970001402 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 562970001403 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 562970001404 active site 562970001405 catalytic tetrad [active] 562970001406 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 562970001407 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 562970001408 Protein of unknown function (DUF444); Region: DUF444; cl17371 562970001409 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 562970001410 SpoVR like protein; Region: SpoVR; pfam04293 562970001411 Domain of unknown function DUF59; Region: DUF59; cl00941 562970001412 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 562970001413 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 562970001414 CPxP motif; other site 562970001415 Uncharacterized conserved protein (DUF2249); Region: DUF2249; cl17719 562970001416 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 562970001417 ATP cone domain; Region: ATP-cone; pfam03477 562970001418 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 562970001419 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 562970001420 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 562970001421 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 562970001422 protein-splicing catalytic site; other site 562970001423 thioester formation/cholesterol transfer; other site 562970001424 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 562970001425 Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; smart00305 562970001426 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 562970001427 TSCPD domain; Region: TSCPD; pfam12637 562970001428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970001429 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970001430 active site 562970001431 phosphorylation site [posttranslational modification] 562970001432 intermolecular recognition site; other site 562970001433 dimerization interface [polypeptide binding]; other site 562970001434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970001435 DNA binding residues [nucleotide binding] 562970001436 dimerization interface [polypeptide binding]; other site 562970001437 Acyltransferase family; Region: Acyl_transf_3; pfam01757 562970001438 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 562970001439 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 562970001440 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 562970001441 Protein of unknown function (DUF444); Region: DUF444; cl17371 562970001442 SpoVR like protein; Region: SpoVR; pfam04293 562970001443 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 562970001444 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 562970001445 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 562970001446 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 562970001447 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 562970001448 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 562970001449 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 562970001450 Ligand Binding Site [chemical binding]; other site 562970001451 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 562970001452 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970001453 FeS/SAM binding site; other site 562970001454 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 562970001455 active site 562970001456 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 562970001457 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 562970001458 putative ATP binding site [chemical binding]; other site 562970001459 putative substrate interface [chemical binding]; other site 562970001460 Arsenate Reductase (ArsC) family; composed of TRX-fold arsenic reductases and similar proteins including the transcriptional regulator, Spx. ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], using reducing equivalents derived from...; Region: ArsC_family; cd02977 562970001461 ArsC family; Region: ArsC; pfam03960 562970001462 catalytic residue [active] 562970001463 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 562970001464 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 562970001465 RNA binding site [nucleotide binding]; other site 562970001466 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 562970001467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001468 D-galactonate transporter; Region: 2A0114; TIGR00893 562970001469 putative substrate translocation pore; other site 562970001470 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 562970001471 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 562970001472 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 562970001473 active site 562970001474 Predicted permeases [General function prediction only]; Region: COG0679 562970001475 Transcriptional regulators [Transcription]; Region: FadR; COG2186 562970001476 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970001477 DNA-binding site [nucleotide binding]; DNA binding site 562970001478 FCD domain; Region: FCD; pfam07729 562970001479 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 562970001480 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970001481 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 562970001482 Switch II region; other site 562970001483 G4 box; other site 562970001484 G5 box; other site 562970001485 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 562970001486 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 562970001487 B12 binding site [chemical binding]; other site 562970001488 cobalt ligand [ion binding]; other site 562970001489 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 562970001490 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 562970001491 NAD(P) binding site [chemical binding]; other site 562970001492 homotetramer interface [polypeptide binding]; other site 562970001493 homodimer interface [polypeptide binding]; other site 562970001494 active site 562970001495 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 562970001496 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970001497 acyl-activating enzyme (AAE) consensus motif; other site 562970001498 AMP binding site [chemical binding]; other site 562970001499 active site 562970001500 CoA binding site [chemical binding]; other site 562970001501 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 562970001502 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 562970001503 cell division protein FtsW; Region: ftsW; TIGR02614 562970001504 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 562970001505 glutamine synthetase, type I; Region: GlnA; TIGR00653 562970001506 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 562970001507 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 562970001508 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 562970001509 Uncharacterized conserved protein [Function unknown]; Region: COG1434 562970001510 putative active site [active] 562970001511 YwhD family; Region: YwhD; pfam08741 562970001512 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 562970001513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 562970001514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970001515 catalytic residue [active] 562970001516 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 562970001517 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 562970001518 Spore germination protein; Region: Spore_permease; cl17796 562970001519 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 562970001520 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 562970001521 Domain of unknown function DUF; Region: DUF204; pfam02659 562970001522 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 562970001523 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970001524 Zn2+ binding site [ion binding]; other site 562970001525 Mg2+ binding site [ion binding]; other site 562970001526 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 562970001527 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 562970001528 DXD motif; other site 562970001529 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 562970001530 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 562970001531 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 562970001532 oligomer interface [polypeptide binding]; other site 562970001533 active site 562970001534 metal binding site [ion binding]; metal-binding site 562970001535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 562970001536 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 562970001537 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 562970001538 catalytic residue [active] 562970001539 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 562970001540 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 562970001541 TPP-binding site [chemical binding]; other site 562970001542 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 562970001543 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 562970001544 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 562970001545 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 562970001546 dimer interface [polypeptide binding]; other site 562970001547 PYR/PP interface [polypeptide binding]; other site 562970001548 TPP binding site [chemical binding]; other site 562970001549 substrate binding site [chemical binding]; other site 562970001550 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970001551 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970001552 DNA-binding site [nucleotide binding]; DNA binding site 562970001553 Transposase domain (DUF772); Region: DUF772; pfam05598 562970001554 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970001555 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970001556 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970001557 seryl-tRNA synthetase; Provisional; Region: PRK05431 562970001558 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 562970001559 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 562970001560 dimer interface [polypeptide binding]; other site 562970001561 active site 562970001562 motif 1; other site 562970001563 motif 2; other site 562970001564 motif 3; other site 562970001565 hydroxyglutarate oxidase; Provisional; Region: PRK11728 562970001566 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 562970001567 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 562970001568 thiamine phosphate binding site [chemical binding]; other site 562970001569 active site 562970001570 pyrophosphate binding site [ion binding]; other site 562970001571 Uncharacterized conserved protein [Function unknown]; Region: COG2445 562970001572 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 562970001573 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 562970001574 NodB motif; other site 562970001575 putative active site [active] 562970001576 putative catalytic site [active] 562970001577 putative Zn binding site [ion binding]; other site 562970001578 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 562970001579 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 562970001580 Divergent PAP2 family; Region: DUF212; pfam02681 562970001581 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 562970001582 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 562970001583 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 562970001584 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 562970001585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970001586 MarR family; Region: MarR_2; pfam12802 562970001587 MarR family; Region: MarR_2; cl17246 562970001588 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 562970001589 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970001590 active site 562970001591 motif I; other site 562970001592 motif II; other site 562970001593 fumarate hydratase; Reviewed; Region: fumC; PRK00485 562970001594 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 562970001595 active sites [active] 562970001596 tetramer interface [polypeptide binding]; other site 562970001597 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 562970001598 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 562970001599 Glutamate binding site [chemical binding]; other site 562970001600 homodimer interface [polypeptide binding]; other site 562970001601 NAD binding site [chemical binding]; other site 562970001602 catalytic residues [active] 562970001603 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 562970001604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970001605 FeS/SAM binding site; other site 562970001606 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 562970001607 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 562970001608 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 562970001609 Walker A/P-loop; other site 562970001610 ATP binding site [chemical binding]; other site 562970001611 Q-loop/lid; other site 562970001612 ABC transporter signature motif; other site 562970001613 Walker B; other site 562970001614 D-loop; other site 562970001615 H-loop/switch region; other site 562970001616 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 562970001617 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 562970001618 Moco binding site; other site 562970001619 metal coordination site [ion binding]; other site 562970001620 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 562970001621 putative active site pocket [active] 562970001622 dimerization interface [polypeptide binding]; other site 562970001623 putative catalytic residue [active] 562970001624 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 562970001625 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 562970001626 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 562970001627 NosL; Region: NosL; cl01769 562970001628 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 562970001629 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970001630 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 562970001631 Walker A/P-loop; other site 562970001632 ATP binding site [chemical binding]; other site 562970001633 Q-loop/lid; other site 562970001634 ABC transporter signature motif; other site 562970001635 Walker B; other site 562970001636 D-loop; other site 562970001637 H-loop/switch region; other site 562970001638 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 562970001639 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 562970001640 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 562970001641 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 562970001642 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 562970001643 Phosphoesterase family; Region: Phosphoesterase; pfam04185 562970001644 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 562970001645 putative active site [active] 562970001646 putative metal binding site [ion binding]; other site 562970001647 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 562970001648 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 562970001649 dimer interface [polypeptide binding]; other site 562970001650 active site 562970001651 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970001652 DNA binding residues [nucleotide binding] 562970001653 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970001654 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970001655 catalytic residues [active] 562970001656 catalytic nucleophile [active] 562970001657 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970001658 ATP-dependent helicase HepA; Validated; Region: PRK04914 562970001659 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 562970001660 Predicted transcriptional regulator [Transcription]; Region: COG2378 562970001661 HTH domain; Region: HTH_11; pfam08279 562970001662 WYL domain; Region: WYL; pfam13280 562970001663 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970001664 HIRAN domain; Region: HIRAN; cl07418 562970001665 Predicted transcriptional regulators [Transcription]; Region: COG1733 562970001666 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 562970001667 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 562970001668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970001669 NAD(P) binding site [chemical binding]; other site 562970001670 active site 562970001671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 562970001672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001673 Predicted transcriptional regulators [Transcription]; Region: COG1695 562970001674 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 562970001675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001676 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970001677 putative substrate translocation pore; other site 562970001678 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 562970001679 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 562970001680 DNA binding residues [nucleotide binding] 562970001681 DinB family; Region: DinB; cl17821 562970001682 DinB superfamily; Region: DinB_2; pfam12867 562970001683 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 562970001684 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970001685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970001686 DNA binding residues [nucleotide binding] 562970001687 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 562970001688 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970001689 Walker A/P-loop; other site 562970001690 ATP binding site [chemical binding]; other site 562970001691 Q-loop/lid; other site 562970001692 ABC transporter signature motif; other site 562970001693 Walker B; other site 562970001694 D-loop; other site 562970001695 H-loop/switch region; other site 562970001696 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 562970001697 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970001698 enoyl-CoA hydratase; Validated; Region: PRK08139 562970001699 substrate binding site [chemical binding]; other site 562970001700 oxyanion hole (OAH) forming residues; other site 562970001701 trimer interface [polypeptide binding]; other site 562970001702 cyanate hydratase; Validated; Region: PRK02866 562970001703 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 562970001704 oligomer interface [polypeptide binding]; other site 562970001705 active site 562970001706 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 562970001707 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 562970001708 active site 562970001709 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 562970001710 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970001711 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970001712 DNA binding residues [nucleotide binding] 562970001713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001714 putative substrate translocation pore; other site 562970001715 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 562970001716 YcfA-like protein; Region: YcfA; cl00752 562970001717 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 562970001718 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 562970001719 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 562970001720 NosL; Region: NosL; cl01769 562970001721 Iron permease FTR1 family; Region: FTR1; cl00475 562970001722 YtkA-like; Region: YtkA; pfam13115 562970001723 Protein of unknown function (DUF420); Region: DUF420; pfam04238 562970001724 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 562970001725 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 562970001726 active site 562970001727 dimer interface [polypeptide binding]; other site 562970001728 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 562970001729 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 562970001730 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 562970001731 Soluble P-type ATPase [General function prediction only]; Region: COG4087 562970001732 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 562970001733 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 562970001734 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 562970001735 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 562970001736 Ligand Binding Site [chemical binding]; other site 562970001737 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 562970001738 GAF domain; Region: GAF_3; pfam13492 562970001739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970001740 dimer interface [polypeptide binding]; other site 562970001741 phosphorylation site [posttranslational modification] 562970001742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970001743 ATP binding site [chemical binding]; other site 562970001744 Mg2+ binding site [ion binding]; other site 562970001745 G-X-G motif; other site 562970001746 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 562970001747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970001748 active site 562970001749 phosphorylation site [posttranslational modification] 562970001750 intermolecular recognition site; other site 562970001751 dimerization interface [polypeptide binding]; other site 562970001752 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970001753 DNA binding site [nucleotide binding] 562970001754 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 562970001755 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 562970001756 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 562970001757 Walker A/P-loop; other site 562970001758 ATP binding site [chemical binding]; other site 562970001759 Q-loop/lid; other site 562970001760 ABC transporter signature motif; other site 562970001761 Walker B; other site 562970001762 D-loop; other site 562970001763 H-loop/switch region; other site 562970001764 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 562970001765 FeS assembly protein SufD; Region: sufD; TIGR01981 562970001766 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 562970001767 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 562970001768 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970001769 catalytic residue [active] 562970001770 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 562970001771 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 562970001772 trimerization site [polypeptide binding]; other site 562970001773 active site 562970001774 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 562970001775 FeS assembly protein SufB; Region: sufB; TIGR01980 562970001776 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 562970001777 [2Fe-2S] cluster binding site [ion binding]; other site 562970001778 Rrf2 family protein; Region: rrf2_super; TIGR00738 562970001779 Transcriptional regulator; Region: Rrf2; pfam02082 562970001780 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 562970001781 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 562970001782 enoyl-CoA hydratase; Provisional; Region: PRK06688 562970001783 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970001784 substrate binding site [chemical binding]; other site 562970001785 oxyanion hole (OAH) forming residues; other site 562970001786 trimer interface [polypeptide binding]; other site 562970001787 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 562970001788 nudix motif; other site 562970001789 Putative membrane protein; Region: YuiB; pfam14068 562970001790 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 562970001791 dimer interface [polypeptide binding]; other site 562970001792 substrate binding site [chemical binding]; other site 562970001793 metal binding sites [ion binding]; metal-binding site 562970001794 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970001795 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970001796 Protein of unknown function, DUF485; Region: DUF485; pfam04341 562970001797 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 562970001798 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 562970001799 Na binding site [ion binding]; other site 562970001800 calcium/proton exchanger (cax); Region: cax; TIGR00378 562970001801 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 562970001802 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 562970001803 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 562970001804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 562970001805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 562970001806 catalytic residue [active] 562970001807 threonine dehydratase; Provisional; Region: PRK08198 562970001808 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 562970001809 tetramer interface [polypeptide binding]; other site 562970001810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970001811 catalytic residue [active] 562970001812 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 562970001813 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 562970001814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 562970001815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970001816 homodimer interface [polypeptide binding]; other site 562970001817 catalytic residue [active] 562970001818 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 562970001819 Chorismate mutase type II; Region: CM_2; cl00693 562970001820 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 562970001821 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 562970001822 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 562970001823 active site 562970001824 Zn binding site [ion binding]; other site 562970001825 FOG: CBS domain [General function prediction only]; Region: COG0517 562970001826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 562970001827 C-terminal ACT domain of the Bacillus subtilis acetoin utilization protein, AcuB; Region: ACT_AcuB; cd04883 562970001828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 562970001829 acetyl-CoA synthetase; Provisional; Region: PRK04319 562970001830 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 562970001831 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 562970001832 active site 562970001833 acyl-activating enzyme (AAE) consensus motif; other site 562970001834 putative CoA binding site [chemical binding]; other site 562970001835 AMP binding site [chemical binding]; other site 562970001836 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 562970001837 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970001838 inhibitor-cofactor binding pocket; inhibition site 562970001839 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970001840 catalytic residue [active] 562970001841 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 562970001842 hydrophobic ligand binding site; other site 562970001843 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 562970001844 NAD(P) binding pocket [chemical binding]; other site 562970001845 This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298 562970001846 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 562970001847 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 562970001848 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970001849 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 562970001850 CPxP motif; other site 562970001851 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 562970001852 active site residue [active] 562970001853 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 562970001854 PAS domain; Region: PAS_8; pfam13188 562970001855 PAS fold; Region: PAS_4; pfam08448 562970001856 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 562970001857 Histidine kinase; Region: HisKA_3; pfam07730 562970001858 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970001859 ATP binding site [chemical binding]; other site 562970001860 Mg2+ binding site [ion binding]; other site 562970001861 G-X-G motif; other site 562970001862 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970001863 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970001864 active site 562970001865 phosphorylation site [posttranslational modification] 562970001866 intermolecular recognition site; other site 562970001867 dimerization interface [polypeptide binding]; other site 562970001868 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970001869 DNA binding residues [nucleotide binding] 562970001870 dimerization interface [polypeptide binding]; other site 562970001871 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970001872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970001873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970001874 putative substrate translocation pore; other site 562970001875 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 562970001876 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 562970001877 active site 562970001878 HIGH motif; other site 562970001879 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 562970001880 active site 562970001881 KMSKS motif; other site 562970001882 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 562970001883 FAD binding domain; Region: FAD_binding_4; pfam01565 562970001884 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 562970001885 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 562970001886 TPP-binding site [chemical binding]; other site 562970001887 tetramer interface [polypeptide binding]; other site 562970001888 heterodimer interface [polypeptide binding]; other site 562970001889 phosphorylation loop region [posttranslational modification] 562970001890 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 562970001891 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 562970001892 alpha subunit interface [polypeptide binding]; other site 562970001893 TPP binding site [chemical binding]; other site 562970001894 heterodimer interface [polypeptide binding]; other site 562970001895 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970001896 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 562970001897 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 562970001898 E3 interaction surface; other site 562970001899 lipoyl attachment site [posttranslational modification]; other site 562970001900 e3 binding domain; Region: E3_binding; pfam02817 562970001901 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 562970001902 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 562970001903 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 562970001904 catalytic residues [active] 562970001905 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 562970001906 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 562970001907 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 562970001908 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 562970001909 active site 562970001910 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 562970001911 metal binding triad; other site 562970001912 hypothetical protein; Provisional; Region: PRK07740 562970001913 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 562970001914 active site 562970001915 catalytic site [active] 562970001916 substrate binding site [chemical binding]; other site 562970001917 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 562970001918 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 562970001919 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 562970001920 putative active site [active] 562970001921 metal binding site [ion binding]; metal-binding site 562970001922 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 562970001923 FAD binding site [chemical binding]; other site 562970001924 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 562970001925 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 562970001926 active site 562970001927 HIGH motif; other site 562970001928 dimer interface [polypeptide binding]; other site 562970001929 KMSKS motif; other site 562970001930 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 562970001931 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 562970001932 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 562970001933 GIY-YIG motif/motif A; other site 562970001934 active site 562970001935 catalytic site [active] 562970001936 putative DNA binding site [nucleotide binding]; other site 562970001937 metal binding site [ion binding]; metal-binding site 562970001938 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 562970001939 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 562970001940 DNA binding site [nucleotide binding] 562970001941 hypothetical protein; Provisional; Region: PRK09936 562970001942 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970001943 acyl-activating enzyme (AAE) consensus motif; other site 562970001944 aspartate kinase; Reviewed; Region: PRK06635 562970001945 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 562970001946 putative catalytic residues [active] 562970001947 putative nucleotide binding site [chemical binding]; other site 562970001948 putative aspartate binding site [chemical binding]; other site 562970001949 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 562970001950 putative allosteric regulatory site; other site 562970001951 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 562970001952 putative allosteric regulatory residue; other site 562970001953 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 562970001954 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 562970001955 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 562970001956 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 562970001957 putative Iron-sulfur protein interface [polypeptide binding]; other site 562970001958 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 562970001959 proximal heme binding site [chemical binding]; other site 562970001960 distal heme binding site [chemical binding]; other site 562970001961 putative dimer interface [polypeptide binding]; other site 562970001962 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 562970001963 L-aspartate oxidase; Provisional; Region: PRK06175 562970001964 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 562970001965 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 562970001966 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 562970001967 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970001968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970001969 DNA binding residues [nucleotide binding] 562970001970 dimerization interface [polypeptide binding]; other site 562970001971 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 562970001972 MarR family; Region: MarR; pfam01047 562970001973 Sporulation and spore germination; Region: Germane; pfam10646 562970001974 Sporulation and spore germination; Region: Germane; cl11253 562970001975 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 562970001976 active site 562970001977 dimerization interface [polypeptide binding]; other site 562970001978 trigger factor; Provisional; Region: tig; PRK01490 562970001979 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 562970001980 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 562970001981 Clp protease; Region: CLP_protease; pfam00574 562970001982 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 562970001983 oligomer interface [polypeptide binding]; other site 562970001984 active site residues [active] 562970001985 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 562970001986 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 562970001987 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970001988 Walker A motif; other site 562970001989 ATP binding site [chemical binding]; other site 562970001990 Walker B motif; other site 562970001991 arginine finger; other site 562970001992 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 562970001993 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 562970001994 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970001995 Walker A motif; other site 562970001996 ATP binding site [chemical binding]; other site 562970001997 Walker B motif; other site 562970001998 arginine finger; other site 562970001999 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 562970002000 Transposase domain (DUF772); Region: DUF772; pfam05598 562970002001 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970002002 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970002003 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970002004 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 562970002005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970002006 Walker A motif; other site 562970002007 ATP binding site [chemical binding]; other site 562970002008 Walker B motif; other site 562970002009 arginine finger; other site 562970002010 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 562970002011 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 562970002012 G1 box; other site 562970002013 GTP/Mg2+ binding site [chemical binding]; other site 562970002014 Switch I region; other site 562970002015 G2 box; other site 562970002016 G3 box; other site 562970002017 Switch II region; other site 562970002018 G4 box; other site 562970002019 G5 box; other site 562970002020 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 562970002021 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 562970002022 tRNA; other site 562970002023 putative tRNA binding site [nucleotide binding]; other site 562970002024 putative NADP binding site [chemical binding]; other site 562970002025 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 562970002026 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 562970002027 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 562970002028 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 562970002029 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 562970002030 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 562970002031 domain interfaces; other site 562970002032 active site 562970002033 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 562970002034 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 562970002035 active site 562970002036 SAM binding site [chemical binding]; other site 562970002037 homodimer interface [polypeptide binding]; other site 562970002038 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 562970002039 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 562970002040 active site 562970002041 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 562970002042 dimer interface [polypeptide binding]; other site 562970002043 active site 562970002044 Schiff base residues; other site 562970002045 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 562970002046 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 562970002047 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 562970002048 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 562970002049 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970002050 inhibitor-cofactor binding pocket; inhibition site 562970002051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002052 catalytic residue [active] 562970002053 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 562970002054 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970002055 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 562970002056 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 562970002057 HIGH motif; other site 562970002058 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 562970002059 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 562970002060 active site 562970002061 KMSKS motif; other site 562970002062 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 562970002063 tRNA binding surface [nucleotide binding]; other site 562970002064 anticodon binding site; other site 562970002065 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 562970002066 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 562970002067 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970002068 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 562970002069 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 562970002070 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 562970002071 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970002072 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 562970002073 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 562970002074 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 562970002075 Walker A motif; other site 562970002076 ATP binding site [chemical binding]; other site 562970002077 Walker B motif; other site 562970002078 Domain of unknown function (DUF348); Region: DUF348; pfam03990 562970002079 Domain of unknown function (DUF348); Region: DUF348; pfam03990 562970002080 G5 domain; Region: G5; pfam07501 562970002081 3D domain; Region: 3D; cl01439 562970002082 Sporulation related domain; Region: SPOR; pfam05036 562970002083 Maf-like protein; Reviewed; Region: PRK00078 562970002084 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 562970002085 active site 562970002086 dimer interface [polypeptide binding]; other site 562970002087 hypothetical protein; Reviewed; Region: PRK00024 562970002088 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 562970002089 MPN+ (JAMM) motif; other site 562970002090 Zinc-binding site [ion binding]; other site 562970002091 rod shape-determining protein MreB; Provisional; Region: PRK13927 562970002092 MreB and similar proteins; Region: MreB_like; cd10225 562970002093 nucleotide binding site [chemical binding]; other site 562970002094 Mg binding site [ion binding]; other site 562970002095 putative protofilament interaction site [polypeptide binding]; other site 562970002096 RodZ interaction site [polypeptide binding]; other site 562970002097 rod shape-determining protein MreC; Provisional; Region: PRK13922 562970002098 rod shape-determining protein MreC; Region: MreC; pfam04085 562970002099 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 562970002100 septum formation inhibitor; Reviewed; Region: minC; PRK00513 562970002101 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 562970002102 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 562970002103 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 562970002104 Switch I; other site 562970002105 Switch II; other site 562970002106 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 562970002107 Peptidase family M23; Region: Peptidase_M23; pfam01551 562970002108 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 562970002109 Peptidase family M50; Region: Peptidase_M50; pfam02163 562970002110 putative substrate binding region [chemical binding]; other site 562970002111 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 562970002112 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 562970002113 Protein of unknown function (DUF464); Region: DUF464; pfam04327 562970002114 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 562970002115 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970002116 GTPase CgtA; Reviewed; Region: obgE; PRK12297 562970002117 GTP1/OBG; Region: GTP1_OBG; pfam01018 562970002118 Obg GTPase; Region: Obg; cd01898 562970002119 G1 box; other site 562970002120 GTP/Mg2+ binding site [chemical binding]; other site 562970002121 Switch I region; other site 562970002122 G2 box; other site 562970002123 G3 box; other site 562970002124 Switch II region; other site 562970002125 G4 box; other site 562970002126 G5 box; other site 562970002127 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 562970002128 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 562970002129 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 562970002130 active site 562970002131 FMN binding site [chemical binding]; other site 562970002132 substrate binding site [chemical binding]; other site 562970002133 homotetramer interface [polypeptide binding]; other site 562970002134 catalytic residue [active] 562970002135 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 562970002136 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 562970002137 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 562970002138 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 562970002139 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 562970002140 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 562970002141 active site 562970002142 Substrate binding site; other site 562970002143 Mg++ binding site; other site 562970002144 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 562970002145 putative trimer interface [polypeptide binding]; other site 562970002146 putative CoA binding site [chemical binding]; other site 562970002147 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 562970002148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970002149 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 562970002150 hypothetical protein; Validated; Region: PRK07682 562970002151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 562970002152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002153 homodimer interface [polypeptide binding]; other site 562970002154 catalytic residue [active] 562970002155 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 562970002156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970002157 DNA-binding site [nucleotide binding]; DNA binding site 562970002158 AsnC family; Region: AsnC_trans_reg; pfam01037 562970002159 Type II/IV secretion system protein; Region: T2SE; pfam00437 562970002160 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 562970002161 Walker A motif; other site 562970002162 ATP binding site [chemical binding]; other site 562970002163 Walker B motif; other site 562970002164 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 562970002165 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 562970002166 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 562970002167 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 562970002168 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 562970002169 shikimate kinase; Reviewed; Region: aroK; PRK00131 562970002170 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 562970002171 ADP binding site [chemical binding]; other site 562970002172 magnesium binding site [ion binding]; other site 562970002173 putative shikimate binding site; other site 562970002174 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 562970002175 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 562970002176 active site 562970002177 dimer interface [polypeptide binding]; other site 562970002178 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 562970002179 Ligand Binding Site [chemical binding]; other site 562970002180 Molecular Tunnel; other site 562970002181 hypothetical protein; Provisional; Region: PRK04435 562970002182 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 562970002183 threonine synthase; Reviewed; Region: PRK06721 562970002184 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 562970002185 homodimer interface [polypeptide binding]; other site 562970002186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002187 catalytic residue [active] 562970002188 homoserine kinase; Provisional; Region: PRK01212 562970002189 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 562970002190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970002191 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970002192 Walker A motif; other site 562970002193 ATP binding site [chemical binding]; other site 562970002194 Walker B motif; other site 562970002195 arginine finger; other site 562970002196 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 562970002197 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 562970002198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970002199 ATP binding site [chemical binding]; other site 562970002200 putative Mg++ binding site [ion binding]; other site 562970002201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970002202 nucleotide binding region [chemical binding]; other site 562970002203 ATP-binding site [chemical binding]; other site 562970002204 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 562970002205 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 562970002206 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 562970002207 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 562970002208 tetramer interface [polypeptide binding]; other site 562970002209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002210 catalytic residue [active] 562970002211 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 562970002212 tetramer interface [polypeptide binding]; other site 562970002213 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002214 catalytic residue [active] 562970002215 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 562970002216 catalytic core [active] 562970002217 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 562970002218 Dehydroquinase class II; Region: DHquinase_II; pfam01220 562970002219 trimer interface [polypeptide binding]; other site 562970002220 active site 562970002221 dimer interface [polypeptide binding]; other site 562970002222 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 562970002223 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 562970002224 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 562970002225 active site 562970002226 elongation factor P; Validated; Region: PRK00529 562970002227 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 562970002228 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 562970002229 RNA binding site [nucleotide binding]; other site 562970002230 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 562970002231 RNA binding site [nucleotide binding]; other site 562970002232 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 562970002233 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 562970002234 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 562970002235 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 562970002236 Walker A motif; other site 562970002237 ATP binding site [chemical binding]; other site 562970002238 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; pfam09548 562970002239 stage III sporulation protein AC; Region: spore_III_AC; TIGR02848 562970002240 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 562970002241 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 562970002242 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 562970002243 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 562970002244 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 562970002245 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 562970002246 carboxyltransferase (CT) interaction site; other site 562970002247 biotinylation site [posttranslational modification]; other site 562970002248 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 562970002249 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970002250 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 562970002251 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 562970002252 Asp23 family; Region: Asp23; pfam03780 562970002253 Asp23 family; Region: Asp23; cl00574 562970002254 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 562970002255 putative RNA binding site [nucleotide binding]; other site 562970002256 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 562970002257 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 562970002258 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970002259 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970002260 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 562970002261 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 562970002262 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 562970002263 homodimer interface [polypeptide binding]; other site 562970002264 NADP binding site [chemical binding]; other site 562970002265 substrate binding site [chemical binding]; other site 562970002266 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 562970002267 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 562970002268 generic binding surface II; other site 562970002269 generic binding surface I; other site 562970002270 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 562970002271 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 562970002272 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 562970002273 substrate binding pocket [chemical binding]; other site 562970002274 chain length determination region; other site 562970002275 substrate-Mg2+ binding site; other site 562970002276 catalytic residues [active] 562970002277 aspartate-rich region 1; other site 562970002278 active site lid residues [active] 562970002279 aspartate-rich region 2; other site 562970002280 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 562970002281 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 562970002282 TPP-binding site; other site 562970002283 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 562970002284 PYR/PP interface [polypeptide binding]; other site 562970002285 dimer interface [polypeptide binding]; other site 562970002286 TPP binding site [chemical binding]; other site 562970002287 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970002288 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 562970002289 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970002290 RNA binding surface [nucleotide binding]; other site 562970002291 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 562970002292 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 562970002293 ATP-NAD kinase; Region: NAD_kinase; pfam01513 562970002294 arginine repressor; Provisional; Region: PRK04280 562970002295 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 562970002296 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 562970002297 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 562970002298 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 562970002299 Walker A/P-loop; other site 562970002300 ATP binding site [chemical binding]; other site 562970002301 Q-loop/lid; other site 562970002302 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 562970002303 ABC transporter signature motif; other site 562970002304 Walker B; other site 562970002305 D-loop; other site 562970002306 H-loop/switch region; other site 562970002307 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 562970002308 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 562970002309 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 562970002310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970002311 active site 562970002312 phosphorylation site [posttranslational modification] 562970002313 intermolecular recognition site; other site 562970002314 dimerization interface [polypeptide binding]; other site 562970002315 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 562970002316 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 562970002317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970002318 FeS/SAM binding site; other site 562970002319 YfkB-like domain; Region: YfkB; pfam08756 562970002320 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 562970002321 active site 562970002322 catalytic triad [active] 562970002323 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 562970002324 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 562970002325 Domain of unknown function (DUF309); Region: DUF309; pfam03745 562970002326 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 562970002327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970002328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970002329 Transcriptional regulator [Transcription]; Region: LytR; COG1316 562970002330 Bacterial SH3 domain; Region: SH3_3; pfam08239 562970002331 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 562970002332 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 562970002333 putative NAD(P) binding site [chemical binding]; other site 562970002334 putative active site [active] 562970002335 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 562970002336 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 562970002337 homodimer interface [polypeptide binding]; other site 562970002338 substrate-cofactor binding pocket; other site 562970002339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002340 catalytic residue [active] 562970002341 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 562970002342 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 562970002343 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 562970002344 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 562970002345 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 562970002346 Yqey-like protein; Region: YqeY; pfam09424 562970002347 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 562970002348 hypothetical protein; Provisional; Region: PRK13665 562970002349 YabP family; Region: YabP; cl06766 562970002350 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 562970002351 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 562970002352 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 562970002353 PhoH-like protein; Region: PhoH; pfam02562 562970002354 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 562970002355 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 562970002356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970002357 Zn2+ binding site [ion binding]; other site 562970002358 Mg2+ binding site [ion binding]; other site 562970002359 metal-binding heat shock protein; Provisional; Region: PRK00016 562970002360 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 562970002361 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 562970002362 active site 562970002363 GTPase Era; Reviewed; Region: era; PRK00089 562970002364 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 562970002365 G1 box; other site 562970002366 GTP/Mg2+ binding site [chemical binding]; other site 562970002367 Switch I region; other site 562970002368 G2 box; other site 562970002369 Switch II region; other site 562970002370 G3 box; other site 562970002371 G4 box; other site 562970002372 G5 box; other site 562970002373 KH domain; Region: KH_2; pfam07650 562970002374 Recombination protein O N terminal; Region: RecO_N; pfam11967 562970002375 DNA repair protein RecO; Region: reco; TIGR00613 562970002376 Recombination protein O C terminal; Region: RecO_C; pfam02565 562970002377 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 562970002378 motif 1; other site 562970002379 dimer interface [polypeptide binding]; other site 562970002380 active site 562970002381 motif 2; other site 562970002382 motif 3; other site 562970002383 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 562970002384 HTH domain; Region: HTH_11; pfam08279 562970002385 FOG: CBS domain [General function prediction only]; Region: COG0517 562970002386 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 562970002387 PEP synthetase regulatory protein; Provisional; Region: PRK05339 562970002388 pyruvate phosphate dikinase; Provisional; Region: PRK09279 562970002389 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 562970002390 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 562970002391 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 562970002392 DNA primase; Validated; Region: dnaG; PRK05667 562970002393 CHC2 zinc finger; Region: zf-CHC2; pfam01807 562970002394 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 562970002395 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 562970002396 active site 562970002397 metal binding site [ion binding]; metal-binding site 562970002398 interdomain interaction site; other site 562970002399 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 562970002400 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 562970002401 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 562970002402 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 562970002403 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 562970002404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970002405 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 562970002406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970002407 DNA binding residues [nucleotide binding] 562970002408 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970002409 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 562970002410 FAD binding site [chemical binding]; other site 562970002411 homotetramer interface [polypeptide binding]; other site 562970002412 substrate binding pocket [chemical binding]; other site 562970002413 catalytic base [active] 562970002414 acetyl-CoA synthetase; Provisional; Region: PRK00174 562970002415 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970002416 acyl-activating enzyme (AAE) consensus motif; other site 562970002417 AMP binding site [chemical binding]; other site 562970002418 active site 562970002419 CoA binding site [chemical binding]; other site 562970002420 Uncharacterized conserved protein [Function unknown]; Region: COG0327 562970002421 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 562970002422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 562970002423 Uncharacterized conserved protein [Function unknown]; Region: COG0327 562970002424 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 562970002425 Transposase domain (DUF772); Region: DUF772; pfam05598 562970002426 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970002427 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970002428 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 562970002429 Transposase [DNA replication, recombination, and repair]; Region: COG5421 562970002430 Winged helix-turn helix; Region: HTH_29; pfam13551 562970002431 Homeodomain-like domain; Region: HTH_23; pfam13384 562970002432 Homeodomain-like domain; Region: HTH_32; pfam13565 562970002433 Integrase core domain; Region: rve; pfam00665 562970002434 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970002435 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970002436 Helix-turn-helix domain; Region: HTH_17; pfam12728 562970002437 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 562970002438 DNA binding residues [nucleotide binding] 562970002439 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970002440 YwpF-like protein; Region: YwpF; pfam14183 562970002441 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 562970002442 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 562970002443 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 562970002444 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 562970002445 Beta-Casp domain; Region: Beta-Casp; smart01027 562970002446 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 562970002447 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 562970002448 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 562970002449 active site 562970002450 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 562970002451 Spore germination protein; Region: Spore_permease; cl17796 562970002452 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 562970002453 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 562970002454 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 562970002455 adenylosuccinate lyase; Provisional; Region: PRK07492 562970002456 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 562970002457 tetramer interface [polypeptide binding]; other site 562970002458 active site 562970002459 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 562970002460 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 562970002461 ATP binding site [chemical binding]; other site 562970002462 active site 562970002463 substrate binding site [chemical binding]; other site 562970002464 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 562970002465 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 562970002466 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 562970002467 putative active site [active] 562970002468 catalytic triad [active] 562970002469 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 562970002470 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 562970002471 dimerization interface [polypeptide binding]; other site 562970002472 ATP binding site [chemical binding]; other site 562970002473 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 562970002474 dimerization interface [polypeptide binding]; other site 562970002475 ATP binding site [chemical binding]; other site 562970002476 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 562970002477 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 562970002478 active site 562970002479 tetramer interface [polypeptide binding]; other site 562970002480 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970002481 active site 562970002482 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 562970002483 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 562970002484 dimerization interface [polypeptide binding]; other site 562970002485 putative ATP binding site [chemical binding]; other site 562970002486 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 562970002487 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 562970002488 active site 562970002489 substrate binding site [chemical binding]; other site 562970002490 cosubstrate binding site; other site 562970002491 catalytic site [active] 562970002492 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 562970002493 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 562970002494 purine monophosphate binding site [chemical binding]; other site 562970002495 dimer interface [polypeptide binding]; other site 562970002496 putative catalytic residues [active] 562970002497 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 562970002498 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 562970002499 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 562970002500 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 562970002501 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 562970002502 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 562970002503 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 562970002504 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 562970002505 nucleophile elbow; other site 562970002506 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970002507 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970002508 putative substrate translocation pore; other site 562970002509 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 562970002510 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 562970002511 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 562970002512 active site 562970002513 tetramer interface; other site 562970002514 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970002515 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970002516 DNA binding residues [nucleotide binding] 562970002517 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970002518 catalytic residues [active] 562970002519 catalytic nucleophile [active] 562970002520 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970002521 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 562970002522 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 562970002523 Glutamate binding site [chemical binding]; other site 562970002524 homodimer interface [polypeptide binding]; other site 562970002525 NAD binding site [chemical binding]; other site 562970002526 catalytic residues [active] 562970002527 Proline dehydrogenase; Region: Pro_dh; cl03282 562970002528 PAS domain S-box; Region: sensory_box; TIGR00229 562970002529 PAS domain; Region: PAS; smart00091 562970002530 putative active site [active] 562970002531 heme pocket [chemical binding]; other site 562970002532 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 562970002533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970002534 Walker A motif; other site 562970002535 ATP binding site [chemical binding]; other site 562970002536 Walker B motif; other site 562970002537 arginine finger; other site 562970002538 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 562970002539 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 562970002540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970002541 ATP binding site [chemical binding]; other site 562970002542 putative Mg++ binding site [ion binding]; other site 562970002543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970002544 nucleotide binding region [chemical binding]; other site 562970002545 ATP-binding site [chemical binding]; other site 562970002546 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970002547 putative active site [active] 562970002548 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 562970002549 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 562970002550 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970002551 Protein of unknown function (DUF779); Region: DUF779; pfam05610 562970002552 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 562970002553 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970002554 NAD(P) binding site [chemical binding]; other site 562970002555 catalytic residues [active] 562970002556 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 562970002557 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 562970002558 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 562970002559 catalytic Zn binding site [ion binding]; other site 562970002560 structural Zn binding site [ion binding]; other site 562970002561 NAD(P) binding site [chemical binding]; other site 562970002562 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970002563 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 562970002564 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970002565 binding surface 562970002566 TPR motif; other site 562970002567 Tetratricopeptide repeat; Region: TPR_12; pfam13424 562970002568 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 562970002569 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 562970002570 Protein of unknown function, DUF393; Region: DUF393; pfam04134 562970002571 Transcriptional regulators [Transcription]; Region: MarR; COG1846 562970002572 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 562970002573 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 562970002574 catalytic residues [active] 562970002575 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970002576 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970002577 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970002578 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970002579 putative active site [active] 562970002580 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 562970002581 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 562970002582 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 562970002583 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 562970002584 NAD binding site [chemical binding]; other site 562970002585 homodimer interface [polypeptide binding]; other site 562970002586 active site 562970002587 substrate binding site [chemical binding]; other site 562970002588 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970002589 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 562970002590 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 562970002591 NAD binding site [chemical binding]; other site 562970002592 substrate binding site [chemical binding]; other site 562970002593 homodimer interface [polypeptide binding]; other site 562970002594 active site 562970002595 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 562970002596 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 562970002597 NADP binding site [chemical binding]; other site 562970002598 active site 562970002599 putative substrate binding site [chemical binding]; other site 562970002600 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 562970002601 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 562970002602 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 562970002603 substrate binding site; other site 562970002604 tetramer interface; other site 562970002605 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 562970002606 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 562970002607 Probable Catalytic site; other site 562970002608 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 562970002609 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970002610 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 562970002611 Methyltransferase domain; Region: Methyltransf_24; pfam13578 562970002612 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 562970002613 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970002614 Probable Catalytic site; other site 562970002615 metal-binding site 562970002616 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 562970002617 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 562970002618 Probable Catalytic site; other site 562970002619 metal-binding site 562970002620 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 562970002621 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 562970002622 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 562970002623 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 562970002624 Walker A/P-loop; other site 562970002625 ATP binding site [chemical binding]; other site 562970002626 Q-loop/lid; other site 562970002627 ABC transporter signature motif; other site 562970002628 Walker B; other site 562970002629 D-loop; other site 562970002630 H-loop/switch region; other site 562970002631 Winged helix-turn helix; Region: HTH_29; pfam13551 562970002632 Helix-turn-helix domain; Region: HTH_28; pfam13518 562970002633 Integrase core domain; Region: rve; pfam00665 562970002634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970002635 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 562970002636 NAD(P) binding site [chemical binding]; other site 562970002637 active site 562970002638 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 562970002639 CoA binding domain; Region: CoA_binding; cl17356 562970002640 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 562970002641 NAD(P) binding site [chemical binding]; other site 562970002642 homodimer interface [polypeptide binding]; other site 562970002643 substrate binding site [chemical binding]; other site 562970002644 active site 562970002645 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 562970002646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970002647 putative ADP-binding pocket [chemical binding]; other site 562970002648 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 562970002649 Bacterial sugar transferase; Region: Bac_transf; pfam02397 562970002650 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 562970002651 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 562970002652 putative trimer interface [polypeptide binding]; other site 562970002653 putative CoA binding site [chemical binding]; other site 562970002654 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 562970002655 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 562970002656 inhibitor-cofactor binding pocket; inhibition site 562970002657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002658 catalytic residue [active] 562970002659 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 562970002660 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970002661 FeS/SAM binding site; other site 562970002662 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 562970002663 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 562970002664 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 562970002665 putative active site [active] 562970002666 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 562970002667 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970002668 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 562970002669 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 562970002670 tetramer interface [polypeptide binding]; other site 562970002671 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 562970002672 active site 562970002673 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 562970002674 active site 562970002675 homotetramer interface [polypeptide binding]; other site 562970002676 homodimer interface [polypeptide binding]; other site 562970002677 PAS domain S-box; Region: sensory_box; TIGR00229 562970002678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970002679 putative active site [active] 562970002680 heme pocket [chemical binding]; other site 562970002681 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970002682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970002683 Walker A motif; other site 562970002684 ATP binding site [chemical binding]; other site 562970002685 Walker B motif; other site 562970002686 arginine finger; other site 562970002687 benzoate transport; Region: 2A0115; TIGR00895 562970002688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970002689 putative substrate translocation pore; other site 562970002690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970002691 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 562970002692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970002693 non-specific DNA binding site [nucleotide binding]; other site 562970002694 salt bridge; other site 562970002695 sequence-specific DNA binding site [nucleotide binding]; other site 562970002696 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 562970002697 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 562970002698 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 562970002699 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 562970002700 active site 562970002701 NTP binding site [chemical binding]; other site 562970002702 metal binding triad [ion binding]; metal-binding site 562970002703 antibiotic binding site [chemical binding]; other site 562970002704 YcfA-like protein; Region: YcfA; pfam07927 562970002705 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 562970002706 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970002707 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970002708 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 562970002709 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 562970002710 metal binding site [ion binding]; metal-binding site 562970002711 dimer interface [polypeptide binding]; other site 562970002712 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 562970002713 active site 562970002714 NTP binding site [chemical binding]; other site 562970002715 metal binding triad [ion binding]; metal-binding site 562970002716 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970002717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970002718 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970002719 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970002720 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970002721 Helix-turn-helix domain; Region: HTH_17; pfam12728 562970002722 PemK-like protein; Region: PemK; pfam02452 562970002723 Predicted aconitase [General function prediction only]; Region: COG1679 562970002724 Protein of unknown function (DUF521); Region: DUF521; pfam04412 562970002725 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 562970002726 substrate binding site [chemical binding]; other site 562970002727 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 562970002728 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 562970002729 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 562970002730 putative active site [active] 562970002731 allantoate amidohydrolase; Reviewed; Region: PRK12890 562970002732 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 562970002733 active site 562970002734 metal binding site [ion binding]; metal-binding site 562970002735 dimer interface [polypeptide binding]; other site 562970002736 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 562970002737 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 562970002738 active site 562970002739 putative substrate binding pocket [chemical binding]; other site 562970002740 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 562970002741 NMT1-like family; Region: NMT1_2; pfam13379 562970002742 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 562970002743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970002744 dimer interface [polypeptide binding]; other site 562970002745 conserved gate region; other site 562970002746 putative PBP binding loops; other site 562970002747 ABC-ATPase subunit interface; other site 562970002748 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 562970002749 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 562970002750 Walker A/P-loop; other site 562970002751 ATP binding site [chemical binding]; other site 562970002752 Q-loop/lid; other site 562970002753 ABC transporter signature motif; other site 562970002754 Walker B; other site 562970002755 D-loop; other site 562970002756 H-loop/switch region; other site 562970002757 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 562970002758 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 562970002759 ligand binding site [chemical binding]; other site 562970002760 NAD binding site [chemical binding]; other site 562970002761 catalytic site [active] 562970002762 urocanate hydratase; Provisional; Region: PRK05414 562970002763 imidazolonepropionase; Validated; Region: PRK09356 562970002764 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 562970002765 active site 562970002766 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970002767 putative active site [active] 562970002768 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 562970002769 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 562970002770 FMN binding site [chemical binding]; other site 562970002771 substrate binding site [chemical binding]; other site 562970002772 putative catalytic residue [active] 562970002773 PrcB C-terminal; Region: PrcB_C; pfam14343 562970002774 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 562970002775 SWIM zinc finger; Region: SWIM; pfam04434 562970002776 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 562970002777 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 562970002778 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970002779 ATP binding site [chemical binding]; other site 562970002780 putative Mg++ binding site [ion binding]; other site 562970002781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970002782 nucleotide binding region [chemical binding]; other site 562970002783 ATP-binding site [chemical binding]; other site 562970002784 hydroxyglutarate oxidase; Provisional; Region: PRK11728 562970002785 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 562970002786 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970002787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 562970002788 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 562970002789 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 562970002790 homoserine dehydrogenase; Provisional; Region: PRK06349 562970002791 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 562970002792 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 562970002793 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 562970002794 gamma-glutamyl kinase; Provisional; Region: PRK05429 562970002795 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 562970002796 nucleotide binding site [chemical binding]; other site 562970002797 homotetrameric interface [polypeptide binding]; other site 562970002798 putative phosphate binding site [ion binding]; other site 562970002799 putative allosteric binding site; other site 562970002800 PUA domain; Region: PUA; pfam01472 562970002801 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 562970002802 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 562970002803 putative catalytic cysteine [active] 562970002804 prephenate dehydratase; Provisional; Region: PRK11898 562970002805 Prephenate dehydratase; Region: PDT; pfam00800 562970002806 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 562970002807 putative L-Phe binding site [chemical binding]; other site 562970002808 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 562970002809 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 562970002810 homodimer interface [polypeptide binding]; other site 562970002811 substrate-cofactor binding pocket; other site 562970002812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970002813 catalytic residue [active] 562970002814 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK06725 562970002815 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 562970002816 PYR/PP interface [polypeptide binding]; other site 562970002817 dimer interface [polypeptide binding]; other site 562970002818 TPP binding site [chemical binding]; other site 562970002819 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 562970002820 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 562970002821 TPP-binding site [chemical binding]; other site 562970002822 dimer interface [polypeptide binding]; other site 562970002823 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 562970002824 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 562970002825 putative valine binding site [chemical binding]; other site 562970002826 dimer interface [polypeptide binding]; other site 562970002827 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 562970002828 ketol-acid reductoisomerase; Provisional; Region: PRK05479 562970002829 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 562970002830 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 562970002831 2-isopropylmalate synthase; Validated; Region: PRK00915 562970002832 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 562970002833 active site 562970002834 catalytic residues [active] 562970002835 metal binding site [ion binding]; metal-binding site 562970002836 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 562970002837 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 562970002838 tartrate dehydrogenase; Region: TTC; TIGR02089 562970002839 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 562970002840 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 562970002841 nucleotide binding site/active site [active] 562970002842 HIT family signature motif; other site 562970002843 catalytic residue [active] 562970002844 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 562970002845 CoA-transferase family III; Region: CoA_transf_3; pfam02515 562970002846 polyphosphate kinase; Provisional; Region: PRK05443 562970002847 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 562970002848 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 562970002849 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 562970002850 putative domain interface [polypeptide binding]; other site 562970002851 putative active site [active] 562970002852 catalytic site [active] 562970002853 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 562970002854 putative domain interface [polypeptide binding]; other site 562970002855 putative active site [active] 562970002856 catalytic site [active] 562970002857 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 562970002858 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 562970002859 nucleotide binding site [chemical binding]; other site 562970002860 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970002861 Zn2+ binding site [ion binding]; other site 562970002862 Mg2+ binding site [ion binding]; other site 562970002863 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 562970002864 Transcriptional regulator [Transcription]; Region: IclR; COG1414 562970002865 Bacterial transcriptional regulator; Region: IclR; pfam01614 562970002866 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 562970002867 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 562970002868 active site 562970002869 metal binding site [ion binding]; metal-binding site 562970002870 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 562970002871 tetramer interface [polypeptide binding]; other site 562970002872 active site 562970002873 Fe binding site [ion binding]; other site 562970002874 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970002875 catalytic loop [active] 562970002876 iron binding site [ion binding]; other site 562970002877 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970002878 dinuclear metal binding motif [ion binding]; other site 562970002879 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 562970002880 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970002881 dinuclear metal binding motif [ion binding]; other site 562970002882 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 562970002883 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 562970002884 catalytic site [active] 562970002885 Activator of aromatic catabolism; Region: XylR_N; pfam06505 562970002886 V4R domain; Region: V4R; pfam02830 562970002887 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 562970002888 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 562970002889 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970002890 catalytic loop [active] 562970002891 iron binding site [ion binding]; other site 562970002892 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 562970002893 FAD binding pocket [chemical binding]; other site 562970002894 conserved FAD binding motif [chemical binding]; other site 562970002895 phosphate binding motif [ion binding]; other site 562970002896 beta-alpha-beta structure motif; other site 562970002897 NAD binding pocket [chemical binding]; other site 562970002898 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 562970002899 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 562970002900 NAD binding site [chemical binding]; other site 562970002901 catalytic residues [active] 562970002902 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 562970002903 acetaldehyde dehydrogenase; Validated; Region: PRK08300 562970002904 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 562970002905 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 562970002906 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 562970002907 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 562970002908 active site 562970002909 catalytic residues [active] 562970002910 metal binding site [ion binding]; metal-binding site 562970002911 DmpG-like communication domain; Region: DmpG_comm; pfam07836 562970002912 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 562970002913 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 562970002914 active site 1 [active] 562970002915 dimer interface [polypeptide binding]; other site 562970002916 hexamer interface [polypeptide binding]; other site 562970002917 active site 2 [active] 562970002918 Domain of unknown function (DUF336); Region: DUF336; pfam03928 562970002919 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 562970002920 SPW repeat; Region: SPW; pfam03779 562970002921 Predicted amidohydrolase [General function prediction only]; Region: COG0388 562970002922 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586 562970002923 putative active site [active] 562970002924 catalytic triad [active] 562970002925 putative dimer interface [polypeptide binding]; other site 562970002926 NAD synthetase; Provisional; Region: PRK13980 562970002927 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 562970002928 homodimer interface [polypeptide binding]; other site 562970002929 NAD binding pocket [chemical binding]; other site 562970002930 ATP binding pocket [chemical binding]; other site 562970002931 Mg binding site [ion binding]; other site 562970002932 active-site loop [active] 562970002933 hypothetical protein; Validated; Region: PRK00110 562970002934 BofC C-terminal domain; Region: BofC_C; pfam08955 562970002935 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 562970002936 active site 562970002937 putative DNA-binding cleft [nucleotide binding]; other site 562970002938 dimer interface [polypeptide binding]; other site 562970002939 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 562970002940 RuvA N terminal domain; Region: RuvA_N; pfam01330 562970002941 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 562970002942 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 562970002943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970002944 Walker A motif; other site 562970002945 ATP binding site [chemical binding]; other site 562970002946 Walker B motif; other site 562970002947 arginine finger; other site 562970002948 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 562970002949 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 562970002950 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 562970002951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970002952 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 562970002953 Transferrin; Region: Transferrin; cl02460 562970002954 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 562970002955 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 562970002956 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 562970002957 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 562970002958 Preprotein translocase subunit; Region: YajC; pfam02699 562970002959 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 562970002960 Predicted membrane protein [Function unknown]; Region: COG2323 562970002961 stage V sporulation protein B; Region: spore_V_B; TIGR02900 562970002962 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 562970002963 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 562970002964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970002965 active site 562970002966 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 562970002967 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970002968 Zn2+ binding site [ion binding]; other site 562970002969 Mg2+ binding site [ion binding]; other site 562970002970 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 562970002971 synthetase active site [active] 562970002972 NTP binding site [chemical binding]; other site 562970002973 metal binding site [ion binding]; metal-binding site 562970002974 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 562970002975 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 562970002976 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 562970002977 putative active site [active] 562970002978 dimerization interface [polypeptide binding]; other site 562970002979 putative tRNAtyr binding site [nucleotide binding]; other site 562970002980 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 562970002981 Dienelactone hydrolase family; Region: DLH; pfam01738 562970002982 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 562970002983 putative ADP-ribose binding site [chemical binding]; other site 562970002984 putative active site [active] 562970002985 Predicted membrane protein [Function unknown]; Region: COG2855 562970002986 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 562970002987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 562970002988 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 562970002989 putative dimerization interface [polypeptide binding]; other site 562970002990 isocitrate lyase; Provisional; Region: PRK15063 562970002991 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 562970002992 tetramer interface [polypeptide binding]; other site 562970002993 active site 562970002994 Mg2+/Mn2+ binding site [ion binding]; other site 562970002995 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 562970002996 malate synthase A; Region: malate_syn_A; TIGR01344 562970002997 active site 562970002998 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 562970002999 malate synthase A; Region: malate_syn_A; TIGR01344 562970003000 active site 562970003001 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 562970003002 homodimer interface [polypeptide binding]; other site 562970003003 substrate-cofactor binding pocket; other site 562970003004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970003005 catalytic residue [active] 562970003006 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 562970003007 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 562970003008 acyl-activating enzyme (AAE) consensus motif; other site 562970003009 putative AMP binding site [chemical binding]; other site 562970003010 putative active site [active] 562970003011 putative CoA binding site [chemical binding]; other site 562970003012 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 562970003013 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 562970003014 active site 562970003015 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 562970003016 generic binding surface I; other site 562970003017 generic binding surface II; other site 562970003018 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 562970003019 Y-family of DNA polymerases; Region: PolY; cl12025 562970003020 active site 562970003021 DNA binding site [nucleotide binding] 562970003022 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 562970003023 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970003024 Zn2+ binding site [ion binding]; other site 562970003025 Mg2+ binding site [ion binding]; other site 562970003026 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 562970003027 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 562970003028 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 562970003029 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970003030 catalytic residue [active] 562970003031 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 562970003032 active site 562970003033 intersubunit interface [polypeptide binding]; other site 562970003034 Zn2+ binding site [ion binding]; other site 562970003035 classical (c) SDRs; Region: SDR_c; cd05233 562970003036 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 562970003037 NAD(P) binding site [chemical binding]; other site 562970003038 active site 562970003039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970003040 non-specific DNA binding site [nucleotide binding]; other site 562970003041 salt bridge; other site 562970003042 sequence-specific DNA binding site [nucleotide binding]; other site 562970003043 tetratricopeptide repeat protein; Provisional; Region: PRK11788 562970003044 Tetratricopeptide repeat; Region: TPR_12; pfam13424 562970003045 Tetratricopeptide repeat; Region: TPR_12; pfam13424 562970003046 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 562970003047 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 562970003048 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 562970003049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970003050 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 562970003051 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 562970003052 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970003053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 562970003054 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 562970003055 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 562970003056 active site 562970003057 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 562970003058 Fe-S cluster binding site [ion binding]; other site 562970003059 active site 562970003060 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 562970003061 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_4; cd05828 562970003062 active site 562970003063 catalytic site [active] 562970003064 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 562970003065 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 562970003066 catalytic site [active] 562970003067 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 562970003068 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970003069 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 562970003070 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 562970003071 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 562970003072 ATP-grasp domain; Region: ATP-grasp_4; cl17255 562970003073 S-layer homology domain; Region: SLH; pfam00395 562970003074 S-layer homology domain; Region: SLH; pfam00395 562970003075 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 562970003076 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 562970003077 homodimer interface [polypeptide binding]; other site 562970003078 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970003079 catalytic residue [active] 562970003080 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 562970003081 nudix motif; other site 562970003082 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 562970003083 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 562970003084 NAD binding site [chemical binding]; other site 562970003085 homotetramer interface [polypeptide binding]; other site 562970003086 homodimer interface [polypeptide binding]; other site 562970003087 substrate binding site [chemical binding]; other site 562970003088 active site 562970003089 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970003090 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 562970003091 short chain dehydrogenase; Provisional; Region: PRK07677 562970003092 NAD(P) binding site [chemical binding]; other site 562970003093 substrate binding site [chemical binding]; other site 562970003094 homotetramer interface [polypeptide binding]; other site 562970003095 active site 562970003096 homodimer interface [polypeptide binding]; other site 562970003097 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 562970003098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 562970003099 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 562970003100 B12 binding site [chemical binding]; other site 562970003101 cobalt ligand [ion binding]; other site 562970003102 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 562970003103 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970003104 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 562970003105 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 562970003106 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 562970003107 dimer interface [polypeptide binding]; other site 562970003108 active site 562970003109 AMP-binding domain protein; Validated; Region: PRK08315 562970003110 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970003111 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 562970003112 acyl-activating enzyme (AAE) consensus motif; other site 562970003113 putative AMP binding site [chemical binding]; other site 562970003114 putative active site [active] 562970003115 putative CoA binding site [chemical binding]; other site 562970003116 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 562970003117 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 562970003118 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 562970003119 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 562970003120 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 562970003121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970003122 substrate binding site [chemical binding]; other site 562970003123 oxyanion hole (OAH) forming residues; other site 562970003124 trimer interface [polypeptide binding]; other site 562970003125 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 562970003126 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 562970003127 dimer interface [polypeptide binding]; other site 562970003128 active site 562970003129 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003130 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003131 active site 562970003132 GAF domain; Region: GAF; pfam01590 562970003133 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970003134 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970003135 DNA binding residues [nucleotide binding] 562970003136 dimerization interface [polypeptide binding]; other site 562970003137 Putative sterol carrier protein [Lipid metabolism]; Region: COG3255 562970003138 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 562970003139 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 562970003140 catalytic Zn binding site [ion binding]; other site 562970003141 NAD(P) binding site [chemical binding]; other site 562970003142 structural Zn binding site [ion binding]; other site 562970003143 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 562970003144 active site 562970003145 diiron metal binding site [ion binding]; other site 562970003146 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 562970003147 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970003148 NAD(P) binding site [chemical binding]; other site 562970003149 catalytic residues [active] 562970003150 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 562970003151 ABC1 family; Region: ABC1; cl17513 562970003152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 562970003153 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 562970003154 Coenzyme A binding pocket [chemical binding]; other site 562970003155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970003156 dimer interface [polypeptide binding]; other site 562970003157 conserved gate region; other site 562970003158 ABC-ATPase subunit interface; other site 562970003159 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 562970003160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970003161 Walker A/P-loop; other site 562970003162 ATP binding site [chemical binding]; other site 562970003163 Q-loop/lid; other site 562970003164 ABC transporter signature motif; other site 562970003165 Walker B; other site 562970003166 D-loop; other site 562970003167 H-loop/switch region; other site 562970003168 TOBE domain; Region: TOBE; pfam03459 562970003169 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 562970003170 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 562970003171 active site 562970003172 metal binding site [ion binding]; metal-binding site 562970003173 Sporulation related domain; Region: SPOR; pfam05036 562970003174 CAAX protease self-immunity; Region: Abi; pfam02517 562970003175 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 562970003176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970003177 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 562970003178 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 562970003179 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 562970003180 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 562970003181 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 562970003182 NifU-like domain; Region: NifU; cl00484 562970003183 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 562970003184 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970003185 inhibitor-cofactor binding pocket; inhibition site 562970003186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970003187 catalytic residue [active] 562970003188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970003190 active site 562970003191 phosphorylation site [posttranslational modification] 562970003192 intermolecular recognition site; other site 562970003193 dimerization interface [polypeptide binding]; other site 562970003194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970003195 DNA binding site [nucleotide binding] 562970003196 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 562970003197 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 562970003198 active site 562970003199 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 562970003200 homodimer interface [polypeptide binding]; other site 562970003201 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 562970003202 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 562970003203 Walker A/P-loop; other site 562970003204 ATP binding site [chemical binding]; other site 562970003205 Q-loop/lid; other site 562970003206 ABC transporter signature motif; other site 562970003207 Walker B; other site 562970003208 D-loop; other site 562970003209 H-loop/switch region; other site 562970003210 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 562970003211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970003212 dimer interface [polypeptide binding]; other site 562970003213 conserved gate region; other site 562970003214 putative PBP binding loops; other site 562970003215 ABC-ATPase subunit interface; other site 562970003216 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 562970003217 NMT1-like family; Region: NMT1_2; pfam13379 562970003218 substrate binding pocket [chemical binding]; other site 562970003219 membrane-bound complex binding site; other site 562970003220 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970003221 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970003222 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 562970003223 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 562970003224 dimer interface [polypeptide binding]; other site 562970003225 motif 1; other site 562970003226 active site 562970003227 motif 2; other site 562970003228 motif 3; other site 562970003229 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 562970003230 anticodon binding site; other site 562970003231 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 562970003232 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 562970003233 dimer interface [polypeptide binding]; other site 562970003234 anticodon binding site; other site 562970003235 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 562970003236 homodimer interface [polypeptide binding]; other site 562970003237 motif 1; other site 562970003238 active site 562970003239 motif 2; other site 562970003240 GAD domain; Region: GAD; pfam02938 562970003241 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 562970003242 motif 3; other site 562970003243 recombination factor protein RarA; Reviewed; Region: PRK13342 562970003244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970003245 Walker A motif; other site 562970003246 ATP binding site [chemical binding]; other site 562970003247 Walker B motif; other site 562970003248 arginine finger; other site 562970003249 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 562970003250 Predicted transcriptional regulator [Transcription]; Region: COG1959 562970003251 Transcriptional regulator; Region: Rrf2; pfam02082 562970003252 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 562970003253 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 562970003254 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970003255 catalytic residue [active] 562970003256 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 562970003257 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 562970003258 Ligand Binding Site [chemical binding]; other site 562970003259 SPW repeat; Region: SPW; pfam03779 562970003260 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 562970003261 Uncharacterized conserved protein [Function unknown]; Region: COG5609 562970003262 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970003263 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 562970003264 catalytic loop [active] 562970003265 iron binding site [ion binding]; other site 562970003266 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 562970003267 4Fe-4S binding domain; Region: Fer4; pfam00037 562970003268 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 562970003269 [4Fe-4S] binding site [ion binding]; other site 562970003270 molybdopterin cofactor binding site; other site 562970003271 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 562970003272 molybdopterin cofactor binding site; other site 562970003273 Uncharacterized conserved protein [Function unknown]; Region: COG2427 562970003274 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 562970003275 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 562970003276 dimer interface [polypeptide binding]; other site 562970003277 putative functional site; other site 562970003278 putative MPT binding site; other site 562970003279 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 562970003280 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 562970003281 GTP binding site; other site 562970003282 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 562970003283 UbiA prenyltransferase family; Region: UbiA; pfam01040 562970003284 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 562970003285 Domain of unknown function DUF20; Region: UPF0118; pfam01594 562970003286 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 562970003287 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 562970003288 motif 1; other site 562970003289 active site 562970003290 motif 2; other site 562970003291 motif 3; other site 562970003292 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 562970003293 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970003294 DNA binding residues [nucleotide binding] 562970003295 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970003296 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970003297 catalytic residues [active] 562970003298 catalytic nucleophile [active] 562970003299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 562970003300 Probable transposase; Region: OrfB_IS605; pfam01385 562970003301 hypothetical protein; Provisional; Region: PRK05473 562970003302 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 562970003303 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 562970003304 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 562970003305 active site 562970003306 NTP binding site [chemical binding]; other site 562970003307 metal binding triad [ion binding]; metal-binding site 562970003308 HEPN domain; Region: HEPN; pfam05168 562970003309 aminodeoxychorismate synthase; Provisional; Region: PRK07508 562970003310 chorismate binding enzyme; Region: Chorismate_bind; cl10555 562970003311 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 562970003312 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 562970003313 substrate-cofactor binding pocket; other site 562970003314 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 562970003315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970003316 Walker A motif; other site 562970003317 ATP binding site [chemical binding]; other site 562970003318 Walker B motif; other site 562970003319 arginine finger; other site 562970003320 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 562970003321 DNA-binding interface [nucleotide binding]; DNA binding site 562970003322 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 562970003323 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 562970003324 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 562970003325 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 562970003326 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 562970003327 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 562970003328 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 562970003329 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 562970003330 Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943 562970003331 acyl-activating enzyme (AAE) consensus motif; other site 562970003332 putative AMP binding site [chemical binding]; other site 562970003333 putative active site [active] 562970003334 putative CoA binding site [chemical binding]; other site 562970003335 GAF domain; Region: GAF; pfam01590 562970003336 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 562970003337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970003338 Walker A motif; other site 562970003339 ATP binding site [chemical binding]; other site 562970003340 Walker B motif; other site 562970003341 arginine finger; other site 562970003342 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 562970003343 DNA-binding interface [nucleotide binding]; DNA binding site 562970003344 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 562970003345 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 562970003346 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 562970003347 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 562970003348 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 562970003349 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 562970003350 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 562970003351 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970003352 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 562970003353 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970003354 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 562970003355 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970003356 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 562970003357 heme-binding site [chemical binding]; other site 562970003358 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970003359 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970003360 dimer interface [polypeptide binding]; other site 562970003361 putative CheW interface [polypeptide binding]; other site 562970003362 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 562970003363 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 562970003364 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 562970003365 DNA binding residues [nucleotide binding] 562970003366 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003367 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003368 active site 562970003369 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 562970003370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970003371 acyl-activating enzyme (AAE) consensus motif; other site 562970003372 AMP binding site [chemical binding]; other site 562970003373 active site 562970003374 CoA binding site [chemical binding]; other site 562970003375 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 562970003376 sulfite reductase subunit beta; Provisional; Region: PRK13504 562970003377 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 562970003378 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 562970003379 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 562970003380 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 562970003381 CoA binding domain; Region: CoA_binding_2; pfam13380 562970003382 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 562970003383 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 562970003384 Acylphosphatase; Region: Acylphosphatase; pfam00708 562970003385 Predicted membrane protein [Function unknown]; Region: COG2323 562970003386 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 562970003387 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 562970003388 active site 562970003389 dimerization interface [polypeptide binding]; other site 562970003390 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 562970003391 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 562970003392 nucleophile elbow; other site 562970003393 YceG-like family; Region: YceG; pfam02618 562970003394 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 562970003395 dimerization interface [polypeptide binding]; other site 562970003396 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 562970003397 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 562970003398 ATP-binding site [chemical binding]; other site 562970003399 Sugar specificity; other site 562970003400 Pyrimidine base specificity; other site 562970003401 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 562970003402 Spore germination protein; Region: Spore_permease; cl17796 562970003403 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 562970003404 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 562970003405 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 562970003406 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 562970003407 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 562970003408 active site 562970003409 NTP binding site [chemical binding]; other site 562970003410 metal binding triad [ion binding]; metal-binding site 562970003411 antibiotic binding site [chemical binding]; other site 562970003412 HEPN domain; Region: HEPN; pfam05168 562970003413 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970003414 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 562970003415 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 562970003416 apolar tunnel; other site 562970003417 heme binding site [chemical binding]; other site 562970003418 dimerization interface [polypeptide binding]; other site 562970003419 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 562970003420 [2Fe-2S] cluster binding site [ion binding]; other site 562970003421 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 562970003422 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970003423 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 562970003424 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 562970003425 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 562970003426 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 562970003427 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 562970003428 [4Fe-4S] binding site [ion binding]; other site 562970003429 molybdopterin cofactor binding site; other site 562970003430 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 562970003431 molybdopterin cofactor binding site; other site 562970003432 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 562970003433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970003434 putative substrate translocation pore; other site 562970003435 ANTAR domain; Region: ANTAR; pfam03861 562970003436 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 562970003437 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 562970003438 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 562970003439 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003440 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 562970003441 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 562970003442 YhfH-like protein; Region: YhfH; pfam14149 562970003443 sporulation sigma factor SigK; Reviewed; Region: PRK05803 562970003444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970003445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970003446 DNA binding residues [nucleotide binding] 562970003447 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 562970003448 CoenzymeA binding site [chemical binding]; other site 562970003449 subunit interaction site [polypeptide binding]; other site 562970003450 PHB binding site; other site 562970003451 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 562970003452 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 562970003453 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003454 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003455 active site 562970003456 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 562970003457 Phosphotransferase enzyme family; Region: APH; pfam01636 562970003458 putative active site [active] 562970003459 putative substrate binding site [chemical binding]; other site 562970003460 ATP binding site [chemical binding]; other site 562970003461 Histidine kinase; Region: HisKA_3; pfam07730 562970003462 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 562970003463 ATP binding site [chemical binding]; other site 562970003464 Mg2+ binding site [ion binding]; other site 562970003465 G-X-G motif; other site 562970003466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 562970003467 active site 562970003468 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970003469 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 562970003470 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970003471 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970003472 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 562970003473 putative metal binding site; other site 562970003474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 562970003475 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970003476 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 562970003477 putative metal binding site; other site 562970003478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970003479 binding surface 562970003480 TPR motif; other site 562970003481 TPR repeat; Region: TPR_11; pfam13414 562970003482 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970003483 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 562970003484 putative metal binding site; other site 562970003485 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970003486 TPR motif; other site 562970003487 binding surface 562970003488 Tetratricopeptide repeat; Region: TPR_12; pfam13424 562970003489 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 562970003490 active site 562970003491 FMN binding site [chemical binding]; other site 562970003492 substrate binding site [chemical binding]; other site 562970003493 3Fe-4S cluster binding site [ion binding]; other site 562970003494 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970003495 dinuclear metal binding motif [ion binding]; other site 562970003496 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 562970003497 glycosyltransferase, MSMEG_0565 family; Region: MSMEG_0565_glyc; TIGR04047 562970003498 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970003499 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 562970003500 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970003501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 562970003502 active site 562970003503 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 562970003504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970003505 NAD(P) binding site [chemical binding]; other site 562970003506 active site 562970003507 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 562970003508 NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426 562970003509 Substrate binding site; other site 562970003510 metal-binding site 562970003511 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 562970003512 NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180 562970003513 NAD binding site [chemical binding]; other site 562970003514 substrate binding site [chemical binding]; other site 562970003515 active site 562970003516 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 562970003517 TrkA-N domain; Region: TrkA_N; pfam02254 562970003518 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 562970003519 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 562970003520 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 562970003521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 562970003522 active site 562970003523 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 562970003524 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 562970003525 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 562970003526 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 562970003527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970003528 active site 562970003529 motif I; other site 562970003530 motif II; other site 562970003531 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 562970003532 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 562970003533 GTP/Mg2+ binding site [chemical binding]; other site 562970003534 G4 box; other site 562970003535 G5 box; other site 562970003536 G1 box; other site 562970003537 Switch I region; other site 562970003538 G2 box; other site 562970003539 G3 box; other site 562970003540 Switch II region; other site 562970003541 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 562970003542 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 562970003543 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 562970003544 shikimate binding site; other site 562970003545 NAD(P) binding site [chemical binding]; other site 562970003546 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 562970003547 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 562970003548 active site 562970003549 (T/H)XGH motif; other site 562970003550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970003551 Zn2+ binding site [ion binding]; other site 562970003552 Mg2+ binding site [ion binding]; other site 562970003553 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 562970003554 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 562970003555 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 562970003556 HIGH motif; other site 562970003557 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 562970003558 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 562970003559 active site 562970003560 KMSKS motif; other site 562970003561 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 562970003562 tRNA binding surface [nucleotide binding]; other site 562970003563 manganese transport transcriptional regulator; Provisional; Region: PRK03902 562970003564 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 562970003565 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 562970003566 SLBB domain; Region: SLBB; pfam10531 562970003567 comEA protein; Region: comE; TIGR01259 562970003568 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 562970003569 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 562970003570 Competence protein; Region: Competence; pfam03772 562970003571 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 562970003572 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 562970003573 putative DNA binding site [nucleotide binding]; other site 562970003574 putative homodimer interface [polypeptide binding]; other site 562970003575 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 562970003576 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970003577 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 562970003578 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 562970003579 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 562970003580 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 562970003581 germination protease; Provisional; Region: PRK02858 562970003582 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 562970003583 stage II sporulation protein P; Region: spore_II_P; TIGR02867 562970003584 GTP-binding protein LepA; Provisional; Region: PRK05433 562970003585 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 562970003586 G1 box; other site 562970003587 putative GEF interaction site [polypeptide binding]; other site 562970003588 GTP/Mg2+ binding site [chemical binding]; other site 562970003589 Switch I region; other site 562970003590 G2 box; other site 562970003591 G3 box; other site 562970003592 Switch II region; other site 562970003593 G4 box; other site 562970003594 G5 box; other site 562970003595 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 562970003596 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 562970003597 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 562970003598 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 562970003599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970003600 FeS/SAM binding site; other site 562970003601 HemN C-terminal domain; Region: HemN_C; pfam06969 562970003602 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 562970003603 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 562970003604 GrpE; Region: GrpE; pfam01025 562970003605 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 562970003606 dimer interface [polypeptide binding]; other site 562970003607 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 562970003608 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 562970003609 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 562970003610 nucleotide binding site [chemical binding]; other site 562970003611 NEF interaction site [polypeptide binding]; other site 562970003612 SBD interface [polypeptide binding]; other site 562970003613 chaperone protein DnaJ; Provisional; Region: PRK10767 562970003614 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 562970003615 HSP70 interaction site [polypeptide binding]; other site 562970003616 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 562970003617 substrate binding site [polypeptide binding]; other site 562970003618 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 562970003619 Zn binding sites [ion binding]; other site 562970003620 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 562970003621 dimer interface [polypeptide binding]; other site 562970003622 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 562970003623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 562970003624 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 562970003625 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970003626 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 562970003627 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 562970003628 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 562970003629 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 562970003630 Phenylacetic acid degradation B; Region: PaaB; cl01371 562970003631 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 562970003632 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 562970003633 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 562970003634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 562970003635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 562970003636 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 562970003637 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970003638 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 562970003639 acyl-activating enzyme (AAE) consensus motif; other site 562970003640 AMP binding site [chemical binding]; other site 562970003641 active site 562970003642 CoA binding site [chemical binding]; other site 562970003643 EthD domain; Region: EthD; cl17553 562970003644 enoyl-CoA hydratase; Provisional; Region: PRK08140 562970003645 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970003646 substrate binding site [chemical binding]; other site 562970003647 oxyanion hole (OAH) forming residues; other site 562970003648 trimer interface [polypeptide binding]; other site 562970003649 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 562970003650 CoenzymeA binding site [chemical binding]; other site 562970003651 subunit interaction site [polypeptide binding]; other site 562970003652 PHB binding site; other site 562970003653 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970003654 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 562970003655 NAD(P) binding site [chemical binding]; other site 562970003656 catalytic residues [active] 562970003657 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 562970003658 active site 2 [active] 562970003659 active site 1 [active] 562970003660 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 562970003661 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 562970003662 dimer interface [polypeptide binding]; other site 562970003663 active site 562970003664 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 562970003665 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 562970003666 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 562970003667 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003668 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003669 active site 562970003670 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 562970003671 Transcriptional regulator [Transcription]; Region: IclR; COG1414 562970003672 Bacterial transcriptional regulator; Region: IclR; pfam01614 562970003673 Suppression of tumorigenicity 7; Region: ST7; cd11557 562970003674 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 562970003675 RNA methyltransferase, RsmE family; Region: TIGR00046 562970003676 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 562970003677 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 562970003678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970003679 FeS/SAM binding site; other site 562970003680 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 562970003681 active site 562970003682 Ap6A binding site [chemical binding]; other site 562970003683 nudix motif; other site 562970003684 metal binding site [ion binding]; metal-binding site 562970003685 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 562970003686 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 562970003687 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 562970003688 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 562970003689 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 562970003690 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 562970003691 putative RNA binding site [nucleotide binding]; other site 562970003692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970003693 S-adenosylmethionine binding site [chemical binding]; other site 562970003694 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 562970003695 MOSC domain; Region: MOSC; pfam03473 562970003696 3-alpha domain; Region: 3-alpha; pfam03475 562970003697 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_3; cd10035 562970003698 putative uracil binding site [chemical binding]; other site 562970003699 putative active site [active] 562970003700 Transcriptional regulators [Transcription]; Region: GntR; COG1802 562970003701 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970003702 DNA-binding site [nucleotide binding]; DNA binding site 562970003703 FCD domain; Region: FCD; pfam07729 562970003704 Domain of unknown function (DUF427); Region: DUF427; pfam04248 562970003705 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 562970003706 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 562970003707 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 562970003708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 562970003709 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 562970003710 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 562970003711 putative active site [active] 562970003712 putative catalytic site [active] 562970003713 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 562970003714 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 562970003715 NAD(P) binding site [chemical binding]; other site 562970003716 homotetramer interface [polypeptide binding]; other site 562970003717 homodimer interface [polypeptide binding]; other site 562970003718 active site 562970003719 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 562970003720 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 562970003721 DUF35 OB-fold domain; Region: DUF35; pfam01796 562970003722 thiolase; Provisional; Region: PRK06158 562970003723 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 562970003724 active site 562970003725 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 562970003726 CoA-transferase family III; Region: CoA_transf_3; pfam02515 562970003727 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 562970003728 active site 2 [active] 562970003729 active site 1 [active] 562970003730 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 562970003731 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970003732 enoyl-CoA hydratase; Provisional; Region: PRK07657 562970003733 substrate binding site [chemical binding]; other site 562970003734 oxyanion hole (OAH) forming residues; other site 562970003735 trimer interface [polypeptide binding]; other site 562970003736 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 562970003737 CoA-transferase family III; Region: CoA_transf_3; pfam02515 562970003738 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003739 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003740 active site 562970003741 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 562970003742 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 562970003743 active site 562970003744 catalytic residues [active] 562970003745 metal binding site [ion binding]; metal-binding site 562970003746 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 562970003747 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970003748 NAD(P) binding site [chemical binding]; other site 562970003749 active site 562970003750 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 562970003751 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 562970003752 active site 562970003753 FMN binding site [chemical binding]; other site 562970003754 2,4-decadienoyl-CoA binding site; other site 562970003755 catalytic residue [active] 562970003756 4Fe-4S cluster binding site [ion binding]; other site 562970003757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 562970003758 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 562970003759 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970003760 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970003761 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003762 active site 562970003763 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970003764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970003765 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970003766 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970003767 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 562970003768 substrate binding site [chemical binding]; other site 562970003769 oxyanion hole (OAH) forming residues; other site 562970003770 trimer interface [polypeptide binding]; other site 562970003771 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase; Region: benzo_BadH; TIGR03206 562970003772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970003773 NAD(P) binding site [chemical binding]; other site 562970003774 active site 562970003775 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003776 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003777 active site 562970003778 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 562970003779 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 562970003780 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 562970003781 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 562970003782 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 562970003783 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 562970003784 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 562970003785 dimer interface [polypeptide binding]; other site 562970003786 acyl-activating enzyme (AAE) consensus motif; other site 562970003787 putative active site [active] 562970003788 AMP binding site [chemical binding]; other site 562970003789 putative CoA binding site [chemical binding]; other site 562970003790 GAF domain; Region: GAF; pfam01590 562970003791 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 562970003792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970003793 Walker A motif; other site 562970003794 ATP binding site [chemical binding]; other site 562970003795 Walker B motif; other site 562970003796 arginine finger; other site 562970003797 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 562970003798 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 562970003799 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 562970003800 catalytic Zn binding site [ion binding]; other site 562970003801 structural Zn binding site [ion binding]; other site 562970003802 tetramer interface [polypeptide binding]; other site 562970003803 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 562970003804 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003805 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003806 active site 562970003807 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970003808 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970003809 enoyl-CoA hydratase; Provisional; Region: PRK06688 562970003810 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970003811 substrate binding site [chemical binding]; other site 562970003812 oxyanion hole (OAH) forming residues; other site 562970003813 trimer interface [polypeptide binding]; other site 562970003814 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 562970003815 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970003816 NAD(P) binding site [chemical binding]; other site 562970003817 catalytic residues [active] 562970003818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970003819 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 562970003820 NAD(P) binding site [chemical binding]; other site 562970003821 active site 562970003822 putative heme peroxidase; Provisional; Region: PRK12276 562970003823 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 562970003824 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 562970003825 dimer interface [polypeptide binding]; other site 562970003826 decamer (pentamer of dimers) interface [polypeptide binding]; other site 562970003827 catalytic triad [active] 562970003828 peroxidatic and resolving cysteines [active] 562970003829 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 562970003830 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 562970003831 catalytic residues [active] 562970003832 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 562970003833 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 562970003834 Probable transposase; Region: OrfB_IS605; pfam01385 562970003835 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970003836 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970003837 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 562970003838 DNA binding residues [nucleotide binding] 562970003839 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970003840 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 562970003841 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 562970003842 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 562970003843 dimer interface [polypeptide binding]; other site 562970003844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970003845 catalytic residue [active] 562970003846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970003847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970003848 putative substrate translocation pore; other site 562970003849 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 562970003850 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 562970003851 putative acyl-acceptor binding pocket; other site 562970003852 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 562970003853 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 562970003854 ATP binding site [chemical binding]; other site 562970003855 substrate interface [chemical binding]; other site 562970003856 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 562970003857 trimer interface [polypeptide binding]; other site 562970003858 dimer interface [polypeptide binding]; other site 562970003859 putative active site [active] 562970003860 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 562970003861 MPT binding site; other site 562970003862 trimer interface [polypeptide binding]; other site 562970003863 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 562970003864 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 562970003865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970003866 putative active site [active] 562970003867 heme pocket [chemical binding]; other site 562970003868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970003869 putative active site [active] 562970003870 heme pocket [chemical binding]; other site 562970003871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970003872 Walker A motif; other site 562970003873 ATP binding site [chemical binding]; other site 562970003874 Walker B motif; other site 562970003875 arginine finger; other site 562970003876 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 562970003877 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 562970003878 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 562970003879 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 562970003880 NAD binding site [chemical binding]; other site 562970003881 Phe binding site; other site 562970003882 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 562970003883 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 562970003884 tetramer interface [polypeptide binding]; other site 562970003885 TPP-binding site [chemical binding]; other site 562970003886 heterodimer interface [polypeptide binding]; other site 562970003887 phosphorylation loop region [posttranslational modification] 562970003888 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 562970003889 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 562970003890 alpha subunit interface [polypeptide binding]; other site 562970003891 TPP binding site [chemical binding]; other site 562970003892 heterodimer interface [polypeptide binding]; other site 562970003893 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970003894 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 562970003895 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 562970003896 E3 interaction surface; other site 562970003897 lipoyl attachment site [posttranslational modification]; other site 562970003898 e3 binding domain; Region: E3_binding; pfam02817 562970003899 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 562970003900 lipoyl synthase; Provisional; Region: PRK05481 562970003901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970003902 FeS/SAM binding site; other site 562970003903 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 562970003904 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 562970003905 B12 binding site [chemical binding]; other site 562970003906 cobalt ligand [ion binding]; other site 562970003907 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 562970003908 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 562970003909 dimer interface [polypeptide binding]; other site 562970003910 substrate binding site [chemical binding]; other site 562970003911 metal binding site [ion binding]; metal-binding site 562970003912 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 562970003913 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 562970003914 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 562970003915 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 562970003916 peptidase T-like protein; Region: PepT-like; TIGR01883 562970003917 metal binding site [ion binding]; metal-binding site 562970003918 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 562970003919 dimer interface [polypeptide binding]; other site 562970003920 ADP-ribose binding site [chemical binding]; other site 562970003921 active site 562970003922 nudix motif; other site 562970003923 metal binding site [ion binding]; metal-binding site 562970003924 TIGR00375 family protein; Region: TIGR00375 562970003925 PHP-associated; Region: PHP_C; pfam13263 562970003926 Integral membrane protein DUF95; Region: DUF95; cl00572 562970003927 RNHCP domain; Region: RNHCP; pfam12647 562970003928 ferric uptake regulator; Provisional; Region: fur; PRK09462 562970003929 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 562970003930 metal binding site 2 [ion binding]; metal-binding site 562970003931 putative DNA binding helix; other site 562970003932 metal binding site 1 [ion binding]; metal-binding site 562970003933 dimer interface [polypeptide binding]; other site 562970003934 structural Zn2+ binding site [ion binding]; other site 562970003935 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 562970003936 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 562970003937 hexamer interface [polypeptide binding]; other site 562970003938 ligand binding site [chemical binding]; other site 562970003939 putative active site [active] 562970003940 NAD(P) binding site [chemical binding]; other site 562970003941 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 562970003942 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 562970003943 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 562970003944 active site 562970003945 Int/Topo IB signature motif; other site 562970003946 phosphopentomutase; Provisional; Region: PRK05362 562970003947 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 562970003948 purine nucleoside phosphorylase; Provisional; Region: PRK08202 562970003949 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 562970003950 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 562970003951 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 562970003952 drug efflux system protein MdtG; Provisional; Region: PRK09874 562970003953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970003954 putative substrate translocation pore; other site 562970003955 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 562970003956 lipoprotein signal peptidase; Provisional; Region: PRK14787 562970003957 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 562970003958 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 562970003959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970003960 RNA binding surface [nucleotide binding]; other site 562970003961 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 562970003962 active site 562970003963 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 562970003964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970003965 active site 562970003966 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 562970003967 aspartate carbamoyltransferase; Region: PLN02527 562970003968 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 562970003969 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 562970003970 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 562970003971 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 562970003972 catalytic site [active] 562970003973 subunit interface [polypeptide binding]; other site 562970003974 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 562970003975 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970003976 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 562970003977 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 562970003978 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970003979 ATP-grasp domain; Region: ATP-grasp_4; cl17255 562970003980 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 562970003981 IMP binding site; other site 562970003982 dimer interface [polypeptide binding]; other site 562970003983 interdomain contacts; other site 562970003984 partial ornithine binding site; other site 562970003985 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 562970003986 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 562970003987 FAD binding pocket [chemical binding]; other site 562970003988 FAD binding motif [chemical binding]; other site 562970003989 phosphate binding motif [ion binding]; other site 562970003990 beta-alpha-beta structure motif; other site 562970003991 NAD binding pocket [chemical binding]; other site 562970003992 Iron coordination center [ion binding]; other site 562970003993 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 562970003994 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 562970003995 heterodimer interface [polypeptide binding]; other site 562970003996 active site 562970003997 FMN binding site [chemical binding]; other site 562970003998 homodimer interface [polypeptide binding]; other site 562970003999 substrate binding site [chemical binding]; other site 562970004000 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 562970004001 active site 562970004002 dimer interface [polypeptide binding]; other site 562970004003 allantoate amidohydrolase; Reviewed; Region: PRK09290 562970004004 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 562970004005 active site 562970004006 metal binding site [ion binding]; metal-binding site 562970004007 dimer interface [polypeptide binding]; other site 562970004008 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 562970004009 FAD binding pocket [chemical binding]; other site 562970004010 FAD binding motif [chemical binding]; other site 562970004011 phosphate binding motif [ion binding]; other site 562970004012 beta-alpha-beta structure motif; other site 562970004013 NAD binding pocket [chemical binding]; other site 562970004014 Iron coordination center [ion binding]; other site 562970004015 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 562970004016 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 562970004017 heterodimer interface [polypeptide binding]; other site 562970004018 active site 562970004019 FMN binding site [chemical binding]; other site 562970004020 homodimer interface [polypeptide binding]; other site 562970004021 substrate binding site [chemical binding]; other site 562970004022 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 562970004023 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 562970004024 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 562970004025 benzoate transport; Region: 2A0115; TIGR00895 562970004026 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970004027 putative substrate translocation pore; other site 562970004028 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 562970004029 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970004030 active site 562970004031 Transposase IS200 like; Region: Y1_Tnp; pfam01797 562970004032 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970004033 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970004034 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 562970004035 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970004036 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970004037 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 562970004038 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 562970004039 active site 562970004040 substrate binding site [chemical binding]; other site 562970004041 metal binding site [ion binding]; metal-binding site 562970004042 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 562970004043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970004044 NAD(P) binding site [chemical binding]; other site 562970004045 active site 562970004046 Transposase domain (DUF772); Region: DUF772; pfam05598 562970004047 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970004048 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970004049 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970004050 Spore germination protein; Region: Spore_permease; cl17796 562970004051 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 562970004052 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 562970004053 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 562970004054 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 562970004055 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 562970004056 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 562970004057 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 562970004058 CRISPR system related protein, RAMP superfamily [Defense mechanisms]; Region: COG1604 562970004059 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 562970004060 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 562970004061 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 562970004062 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 562970004063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 562970004064 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 562970004065 Probable transposase; Region: OrfB_IS605; pfam01385 562970004066 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970004067 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 562970004068 amino acid transporter; Region: 2A0306; TIGR00909 562970004069 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 562970004070 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 562970004071 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 562970004072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970004073 Walker A motif; other site 562970004074 ATP binding site [chemical binding]; other site 562970004075 Walker B motif; other site 562970004076 arginine finger; other site 562970004077 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 562970004078 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 562970004079 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 562970004080 dimerization interface [polypeptide binding]; other site 562970004081 ligand binding site [chemical binding]; other site 562970004082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970004083 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 562970004084 TM-ABC transporter signature motif; other site 562970004085 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 562970004086 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 562970004087 TM-ABC transporter signature motif; other site 562970004088 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 562970004089 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 562970004090 Walker A/P-loop; other site 562970004091 ATP binding site [chemical binding]; other site 562970004092 Q-loop/lid; other site 562970004093 ABC transporter signature motif; other site 562970004094 Walker B; other site 562970004095 D-loop; other site 562970004096 H-loop/switch region; other site 562970004097 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 562970004098 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 562970004099 Walker A/P-loop; other site 562970004100 ATP binding site [chemical binding]; other site 562970004101 Q-loop/lid; other site 562970004102 ABC transporter signature motif; other site 562970004103 Walker B; other site 562970004104 D-loop; other site 562970004105 H-loop/switch region; other site 562970004106 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 562970004107 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 562970004108 E3 interaction surface; other site 562970004109 lipoyl attachment site [posttranslational modification]; other site 562970004110 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 562970004111 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 562970004112 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 562970004113 TPP-binding site [chemical binding]; other site 562970004114 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 562970004115 dimer interface [polypeptide binding]; other site 562970004116 PYR/PP interface [polypeptide binding]; other site 562970004117 TPP binding site [chemical binding]; other site 562970004118 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970004119 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970004120 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970004121 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 562970004122 active site clefts [active] 562970004123 zinc binding site [ion binding]; other site 562970004124 dimer interface [polypeptide binding]; other site 562970004125 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970004126 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970004127 active site 562970004128 phosphorylation site [posttranslational modification] 562970004129 intermolecular recognition site; other site 562970004130 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970004131 DNA binding residues [nucleotide binding] 562970004132 dimerization interface [polypeptide binding]; other site 562970004133 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 562970004134 HAMP domain; Region: HAMP; pfam00672 562970004135 dimerization interface [polypeptide binding]; other site 562970004136 Histidine kinase; Region: HisKA_3; pfam07730 562970004137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970004138 ATP binding site [chemical binding]; other site 562970004139 Mg2+ binding site [ion binding]; other site 562970004140 G-X-G motif; other site 562970004141 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 562970004142 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 562970004143 PspC domain; Region: PspC; pfam04024 562970004144 phage shock protein C; Region: phageshock_pspC; TIGR02978 562970004145 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970004146 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970004147 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970004148 DNA binding residues [nucleotide binding] 562970004149 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970004150 catalytic residues [active] 562970004151 catalytic nucleophile [active] 562970004152 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 562970004153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 562970004154 nucleotide binding site [chemical binding]; other site 562970004155 Methyltransferase domain; Region: Methyltransf_31; pfam13847 562970004156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970004157 S-adenosylmethionine binding site [chemical binding]; other site 562970004158 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 562970004159 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970004160 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970004161 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970004162 Dinitrogenase iron-molybdenum cofactor; Region: Nitro_FeMo-Co; pfam02579 562970004163 EamA-like transporter family; Region: EamA; pfam00892 562970004164 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 562970004165 active site 562970004166 catalytic motif [active] 562970004167 Zn binding site [ion binding]; other site 562970004168 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 562970004169 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 562970004170 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 562970004171 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 562970004172 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 562970004173 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 562970004174 nucleotide binding site/active site [active] 562970004175 HIT family signature motif; other site 562970004176 catalytic residue [active] 562970004177 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 562970004178 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 562970004179 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 562970004180 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 562970004181 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970004182 Walker A/P-loop; other site 562970004183 ATP binding site [chemical binding]; other site 562970004184 Q-loop/lid; other site 562970004185 ABC transporter signature motif; other site 562970004186 Walker B; other site 562970004187 D-loop; other site 562970004188 H-loop/switch region; other site 562970004189 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 562970004190 Domain of unknown function (DUF814); Region: DUF814; pfam05670 562970004191 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 562970004192 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 562970004193 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 562970004194 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 562970004195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970004196 motif II; other site 562970004197 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 562970004198 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 562970004199 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 562970004200 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 562970004201 hypothetical protein; Provisional; Region: PRK11820 562970004202 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 562970004203 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 562970004204 hypothetical protein; Provisional; Region: PRK04323 562970004205 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 562970004206 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 562970004207 catalytic site [active] 562970004208 G-X2-G-X-G-K; other site 562970004209 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 562970004210 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 562970004211 Flavoprotein; Region: Flavoprotein; pfam02441 562970004212 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 562970004213 primosome assembly protein PriA; Validated; Region: PRK05580 562970004214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970004215 ATP binding site [chemical binding]; other site 562970004216 putative Mg++ binding site [ion binding]; other site 562970004217 helicase superfamily c-terminal domain; Region: HELICc; smart00490 562970004218 nucleotide binding region [chemical binding]; other site 562970004219 ATP-binding site [chemical binding]; other site 562970004220 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 562970004221 active site 562970004222 catalytic residues [active] 562970004223 metal binding site [ion binding]; metal-binding site 562970004224 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 562970004225 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 562970004226 putative active site [active] 562970004227 substrate binding site [chemical binding]; other site 562970004228 putative cosubstrate binding site; other site 562970004229 catalytic site [active] 562970004230 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 562970004231 substrate binding site [chemical binding]; other site 562970004232 NusB family; Region: NusB; pfam01029 562970004233 putative RNA binding site [nucleotide binding]; other site 562970004234 16S rRNA methyltransferase B; Provisional; Region: PRK14902 562970004235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970004236 S-adenosylmethionine binding site [chemical binding]; other site 562970004237 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 562970004238 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970004239 FeS/SAM binding site; other site 562970004240 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 562970004241 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 562970004242 active site 562970004243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 562970004244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 562970004245 active site 562970004246 ATP binding site [chemical binding]; other site 562970004247 substrate binding site [chemical binding]; other site 562970004248 activation loop (A-loop); other site 562970004249 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 562970004250 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 562970004251 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 562970004252 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 562970004253 GTPase RsgA; Reviewed; Region: PRK00098 562970004254 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 562970004255 RNA binding site [nucleotide binding]; other site 562970004256 homodimer interface [polypeptide binding]; other site 562970004257 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 562970004258 GTPase/Zn-binding domain interface [polypeptide binding]; other site 562970004259 GTP/Mg2+ binding site [chemical binding]; other site 562970004260 G4 box; other site 562970004261 G5 box; other site 562970004262 G1 box; other site 562970004263 Switch I region; other site 562970004264 G2 box; other site 562970004265 G3 box; other site 562970004266 Switch II region; other site 562970004267 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 562970004268 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 562970004269 substrate binding site [chemical binding]; other site 562970004270 hexamer interface [polypeptide binding]; other site 562970004271 metal binding site [ion binding]; metal-binding site 562970004272 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 562970004273 Asp23 family; Region: Asp23; pfam03780 562970004274 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 562970004275 DAK2 domain; Region: Dak2; pfam02734 562970004276 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 562970004277 Y-family of DNA polymerases; Region: PolY; cl12025 562970004278 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970004279 ATP binding site [chemical binding]; other site 562970004280 putative Mg++ binding site [ion binding]; other site 562970004281 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970004282 nucleotide binding region [chemical binding]; other site 562970004283 ATP-binding site [chemical binding]; other site 562970004284 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 562970004285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970004286 S-adenosylmethionine binding site [chemical binding]; other site 562970004287 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 562970004288 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 562970004289 active site 562970004290 (T/H)XGH motif; other site 562970004291 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 562970004292 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 562970004293 active site 562970004294 nucleophile elbow; other site 562970004295 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 562970004296 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 562970004297 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 562970004298 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 562970004299 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 562970004300 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 562970004301 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 562970004302 active site 2 [active] 562970004303 active site 1 [active] 562970004304 putative phosphate acyltransferase; Provisional; Region: PRK05331 562970004305 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 562970004306 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 562970004307 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 562970004308 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 562970004309 NAD(P) binding site [chemical binding]; other site 562970004310 homotetramer interface [polypeptide binding]; other site 562970004311 homodimer interface [polypeptide binding]; other site 562970004312 active site 562970004313 acyl carrier protein; Provisional; Region: acpP; PRK00982 562970004314 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 562970004315 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 562970004316 dimer interface [polypeptide binding]; other site 562970004317 active site 562970004318 ribonuclease III; Reviewed; Region: rnc; PRK00102 562970004319 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 562970004320 dimerization interface [polypeptide binding]; other site 562970004321 active site 562970004322 metal binding site [ion binding]; metal-binding site 562970004323 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 562970004324 dsRNA binding site [nucleotide binding]; other site 562970004325 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 562970004326 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 562970004327 Walker A/P-loop; other site 562970004328 ATP binding site [chemical binding]; other site 562970004329 Q-loop/lid; other site 562970004330 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 562970004331 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 562970004332 ABC transporter signature motif; other site 562970004333 Walker B; other site 562970004334 D-loop; other site 562970004335 H-loop/switch region; other site 562970004336 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 562970004337 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 562970004338 P loop; other site 562970004339 GTP binding site [chemical binding]; other site 562970004340 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 562970004341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970004342 DNA binding residues [nucleotide binding] 562970004343 signal recognition particle protein; Provisional; Region: PRK10867 562970004344 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 562970004345 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 562970004346 P loop; other site 562970004347 GTP binding site [chemical binding]; other site 562970004348 Signal peptide binding domain; Region: SRP_SPB; pfam02978 562970004349 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 562970004350 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 562970004351 RimM N-terminal domain; Region: RimM; pfam01782 562970004352 PRC-barrel domain; Region: PRC; pfam05239 562970004353 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 562970004354 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 562970004355 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 562970004356 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 562970004357 Catalytic site [active] 562970004358 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 562970004359 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 562970004360 GTP/Mg2+ binding site [chemical binding]; other site 562970004361 G4 box; other site 562970004362 G5 box; other site 562970004363 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 562970004364 G1 box; other site 562970004365 G1 box; other site 562970004366 GTP/Mg2+ binding site [chemical binding]; other site 562970004367 Switch I region; other site 562970004368 G2 box; other site 562970004369 G2 box; other site 562970004370 G3 box; other site 562970004371 G3 box; other site 562970004372 Switch II region; other site 562970004373 Switch II region; other site 562970004374 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 562970004375 RNA/DNA hybrid binding site [nucleotide binding]; other site 562970004376 active site 562970004377 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 562970004378 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 562970004379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 562970004380 hypothetical protein; Reviewed; Region: PRK12497 562970004381 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 562970004382 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 562970004383 Ligand binding site [chemical binding]; other site 562970004384 Electron transfer flavoprotein domain; Region: ETF; pfam01012 562970004385 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 562970004386 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 562970004387 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 562970004388 oxidoreductase; Provisional; Region: PRK10015 562970004389 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 562970004390 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 562970004391 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 562970004392 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 562970004393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970004394 Walker A motif; other site 562970004395 ATP binding site [chemical binding]; other site 562970004396 Walker B motif; other site 562970004397 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 562970004398 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 562970004399 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 562970004400 Ligand binding site; other site 562970004401 Putative Catalytic site; other site 562970004402 DXD motif; other site 562970004403 Predicted membrane protein [Function unknown]; Region: COG2246 562970004404 GtrA-like protein; Region: GtrA; pfam04138 562970004405 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 562970004406 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 562970004407 HTH domain; Region: HTH_11; pfam08279 562970004408 3H domain; Region: 3H; pfam02829 562970004409 quinolinate synthetase; Provisional; Region: PRK09375 562970004410 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 562970004411 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 562970004412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970004413 catalytic residue [active] 562970004414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 562970004415 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970004416 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970004417 dimer interface [polypeptide binding]; other site 562970004418 putative CheW interface [polypeptide binding]; other site 562970004419 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 562970004420 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 562970004421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970004422 Walker A motif; other site 562970004423 ATP binding site [chemical binding]; other site 562970004424 Walker B motif; other site 562970004425 arginine finger; other site 562970004426 Peptidase family M41; Region: Peptidase_M41; pfam01434 562970004427 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 562970004428 glutamate racemase; Provisional; Region: PRK00865 562970004429 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 562970004430 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970004431 FeS/SAM binding site; other site 562970004432 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 562970004433 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 562970004434 tetramer interface [polypeptide binding]; other site 562970004435 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970004436 catalytic residue [active] 562970004437 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 562970004438 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 562970004439 CoA-ligase; Region: Ligase_CoA; pfam00549 562970004440 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 562970004441 CoA binding domain; Region: CoA_binding; smart00881 562970004442 CoA-ligase; Region: Ligase_CoA; pfam00549 562970004443 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 562970004444 DNA protecting protein DprA; Region: dprA; TIGR00732 562970004445 DNA topoisomerase I; Validated; Region: PRK05582 562970004446 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 562970004447 active site 562970004448 interdomain interaction site; other site 562970004449 putative metal-binding site [ion binding]; other site 562970004450 nucleotide binding site [chemical binding]; other site 562970004451 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 562970004452 domain I; other site 562970004453 DNA binding groove [nucleotide binding] 562970004454 phosphate binding site [ion binding]; other site 562970004455 domain II; other site 562970004456 domain III; other site 562970004457 nucleotide binding site [chemical binding]; other site 562970004458 catalytic site [active] 562970004459 domain IV; other site 562970004460 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 562970004461 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 562970004462 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 562970004463 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 562970004464 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 562970004465 Glucose inhibited division protein A; Region: GIDA; pfam01134 562970004466 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 562970004467 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 562970004468 active site 562970004469 DNA binding site [nucleotide binding] 562970004470 Int/Topo IB signature motif; other site 562970004471 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 562970004472 active site 562970004473 HslU subunit interaction site [polypeptide binding]; other site 562970004474 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 562970004475 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 562970004476 Walker A motif; other site 562970004477 ATP binding site [chemical binding]; other site 562970004478 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 562970004479 Walker B motif; other site 562970004480 arginine finger; other site 562970004481 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 562970004482 transcriptional repressor CodY; Validated; Region: PRK04158 562970004483 CodY GAF-like domain; Region: CodY; pfam06018 562970004484 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 562970004485 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 562970004486 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 562970004487 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 562970004488 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 562970004489 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 562970004490 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 562970004491 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 562970004492 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 562970004493 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 562970004494 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 562970004495 FliG C-terminal domain; Region: FliG_C; pfam01706 562970004496 flagellar assembly protein H; Validated; Region: fliH; PRK06669 562970004497 Flagellar assembly protein FliH; Region: FliH; pfam02108 562970004498 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 562970004499 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 562970004500 Walker A motif/ATP binding site; other site 562970004501 Walker B motif; other site 562970004502 Uncharacterized conserved protein [Function unknown]; Region: COG3334 562970004503 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 562970004504 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 562970004505 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 562970004506 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 562970004507 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 562970004508 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 562970004509 Flagellar protein (FlbD); Region: FlbD; pfam06289 562970004510 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 562970004511 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 562970004512 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 562970004513 flagellar motor switch protein; Validated; Region: PRK08119 562970004514 CheC-like family; Region: CheC; pfam04509 562970004515 CheC-like family; Region: CheC; pfam04509 562970004516 flagellar motor switch protein FliN; Region: fliN; TIGR02480 562970004517 Response regulator receiver domain; Region: Response_reg; pfam00072 562970004518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970004519 active site 562970004520 phosphorylation site [posttranslational modification] 562970004521 intermolecular recognition site; other site 562970004522 dimerization interface [polypeptide binding]; other site 562970004523 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 562970004524 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 562970004525 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 562970004526 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 562970004527 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 562970004528 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 562970004529 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 562970004530 FHIPEP family; Region: FHIPEP; pfam00771 562970004531 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 562970004532 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970004533 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 562970004534 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970004535 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 562970004536 P-loop; other site 562970004537 CheB methylesterase; Region: CheB_methylest; pfam01339 562970004538 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 562970004539 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 562970004540 putative binding surface; other site 562970004541 active site 562970004542 P2 response regulator binding domain; Region: P2; pfam07194 562970004543 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 562970004544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970004545 ATP binding site [chemical binding]; other site 562970004546 Mg2+ binding site [ion binding]; other site 562970004547 G-X-G motif; other site 562970004548 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 562970004549 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 562970004550 putative CheA interaction surface; other site 562970004551 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 562970004552 CheC-like family; Region: CheC; pfam04509 562970004553 CheC-like family; Region: CheC; pfam04509 562970004554 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 562970004555 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 562970004556 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970004557 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970004558 DNA binding residues [nucleotide binding] 562970004559 Protein of unknown function (DUF342); Region: DUF342; pfam03961 562970004560 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 562970004561 rRNA interaction site [nucleotide binding]; other site 562970004562 S8 interaction site; other site 562970004563 putative laminin-1 binding site; other site 562970004564 elongation factor Ts; Reviewed; Region: tsf; PRK12332 562970004565 UBA/TS-N domain; Region: UBA; pfam00627 562970004566 Elongation factor TS; Region: EF_TS; pfam00889 562970004567 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 562970004568 putative nucleotide binding site [chemical binding]; other site 562970004569 uridine monophosphate binding site [chemical binding]; other site 562970004570 homohexameric interface [polypeptide binding]; other site 562970004571 ribosome recycling factor; Reviewed; Region: frr; PRK00083 562970004572 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 562970004573 hinge region; other site 562970004574 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 562970004575 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 562970004576 catalytic residue [active] 562970004577 putative FPP diphosphate binding site; other site 562970004578 putative FPP binding hydrophobic cleft; other site 562970004579 dimer interface [polypeptide binding]; other site 562970004580 putative IPP diphosphate binding site; other site 562970004581 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 562970004582 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 562970004583 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 562970004584 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 562970004585 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 562970004586 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 562970004587 RIP metalloprotease RseP; Region: TIGR00054 562970004588 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 562970004589 active site 562970004590 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 562970004591 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 562970004592 protein binding site [polypeptide binding]; other site 562970004593 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 562970004594 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 562970004595 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 562970004596 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 562970004597 prolyl-tRNA synthetase; Provisional; Region: PRK09194 562970004598 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 562970004599 dimer interface [polypeptide binding]; other site 562970004600 motif 1; other site 562970004601 active site 562970004602 motif 2; other site 562970004603 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 562970004604 putative deacylase active site [active] 562970004605 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 562970004606 active site 562970004607 motif 3; other site 562970004608 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 562970004609 anticodon binding site; other site 562970004610 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970004611 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 562970004612 Ligand binding site; other site 562970004613 Putative Catalytic site; other site 562970004614 DXD motif; other site 562970004615 DNA polymerase III PolC; Validated; Region: polC; PRK00448 562970004616 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 562970004617 generic binding surface II; other site 562970004618 generic binding surface I; other site 562970004619 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 562970004620 active site 562970004621 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 562970004622 active site 562970004623 catalytic site [active] 562970004624 substrate binding site [chemical binding]; other site 562970004625 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 562970004626 ribosome maturation protein RimP; Reviewed; Region: PRK00092 562970004627 Sm and related proteins; Region: Sm_like; cl00259 562970004628 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 562970004629 putative oligomer interface [polypeptide binding]; other site 562970004630 putative RNA binding site [nucleotide binding]; other site 562970004631 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 562970004632 NusA N-terminal domain; Region: NusA_N; pfam08529 562970004633 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 562970004634 RNA binding site [nucleotide binding]; other site 562970004635 homodimer interface [polypeptide binding]; other site 562970004636 NusA-like KH domain; Region: KH_5; pfam13184 562970004637 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 562970004638 G-X-X-G motif; other site 562970004639 Protein of unknown function (DUF448); Region: DUF448; pfam04296 562970004640 putative RNA binding cleft [nucleotide binding]; other site 562970004641 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 562970004642 translation initiation factor IF-2; Region: IF-2; TIGR00487 562970004643 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 562970004644 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 562970004645 G1 box; other site 562970004646 putative GEF interaction site [polypeptide binding]; other site 562970004647 GTP/Mg2+ binding site [chemical binding]; other site 562970004648 Switch I region; other site 562970004649 G2 box; other site 562970004650 G3 box; other site 562970004651 Switch II region; other site 562970004652 G4 box; other site 562970004653 G5 box; other site 562970004654 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 562970004655 Translation-initiation factor 2; Region: IF-2; pfam11987 562970004656 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 562970004657 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 562970004658 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 562970004659 DHH family; Region: DHH; pfam01368 562970004660 DHHA1 domain; Region: DHHA1; pfam02272 562970004661 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 562970004662 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 562970004663 RNA binding site [nucleotide binding]; other site 562970004664 active site 562970004665 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 562970004666 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 562970004667 active site 562970004668 Riboflavin kinase; Region: Flavokinase; pfam01687 562970004669 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 562970004670 16S/18S rRNA binding site [nucleotide binding]; other site 562970004671 S13e-L30e interaction site [polypeptide binding]; other site 562970004672 25S rRNA binding site [nucleotide binding]; other site 562970004673 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 562970004674 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 562970004675 RNase E interface [polypeptide binding]; other site 562970004676 trimer interface [polypeptide binding]; other site 562970004677 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 562970004678 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 562970004679 RNase E interface [polypeptide binding]; other site 562970004680 trimer interface [polypeptide binding]; other site 562970004681 active site 562970004682 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 562970004683 putative nucleic acid binding region [nucleotide binding]; other site 562970004684 G-X-X-G motif; other site 562970004685 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 562970004686 RNA binding site [nucleotide binding]; other site 562970004687 domain interface; other site 562970004688 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 562970004689 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 562970004690 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 562970004691 putative NAD(P) binding site [chemical binding]; other site 562970004692 catalytic Zn binding site [ion binding]; other site 562970004693 structural Zn binding site [ion binding]; other site 562970004694 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970004695 dinuclear metal binding motif [ion binding]; other site 562970004696 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 562970004697 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970004698 catalytic loop [active] 562970004699 iron binding site [ion binding]; other site 562970004700 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 562970004701 FAD binding pocket [chemical binding]; other site 562970004702 conserved FAD binding motif [chemical binding]; other site 562970004703 phosphate binding motif [ion binding]; other site 562970004704 beta-alpha-beta structure motif; other site 562970004705 NAD binding pocket [chemical binding]; other site 562970004706 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970004707 dinuclear metal binding motif [ion binding]; other site 562970004708 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 562970004709 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970004710 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970004711 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970004712 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 562970004713 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 562970004714 acyl-activating enzyme (AAE) consensus motif; other site 562970004715 putative active site [active] 562970004716 AMP binding site [chemical binding]; other site 562970004717 putative CoA binding site [chemical binding]; other site 562970004718 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 562970004719 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970004720 NAD(P) binding site [chemical binding]; other site 562970004721 catalytic residues [active] 562970004722 Protein of unknown function (DUF779); Region: DUF779; pfam05610 562970004723 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 562970004724 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970004725 Walker A motif; other site 562970004726 ATP binding site [chemical binding]; other site 562970004727 Walker B motif; other site 562970004728 arginine finger; other site 562970004729 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 562970004730 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 562970004731 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 562970004732 NodB motif; other site 562970004733 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 562970004734 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 562970004735 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 562970004736 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 562970004737 trimer interface [polypeptide binding]; other site 562970004738 active site 562970004739 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 562970004740 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970004741 Protein implicated in RNA metabolism, contains PRC-barrel domain [General function prediction only]; Region: COG1873; cl17889 562970004742 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 562970004743 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 562970004744 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 562970004745 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 562970004746 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 562970004747 aspartate kinase I; Reviewed; Region: PRK08210 562970004748 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 562970004749 nucleotide binding site [chemical binding]; other site 562970004750 substrate binding site [chemical binding]; other site 562970004751 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 562970004752 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 562970004753 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 562970004754 dihydrodipicolinate synthase; Region: dapA; TIGR00674 562970004755 dimer interface [polypeptide binding]; other site 562970004756 active site 562970004757 catalytic residue [active] 562970004758 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 562970004759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 562970004760 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 562970004761 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 562970004762 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 562970004763 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 562970004764 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 562970004765 tetramer interface [polypeptide binding]; other site 562970004766 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 562970004767 active site 562970004768 metal binding site [ion binding]; metal-binding site 562970004769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970004770 DNA-binding site [nucleotide binding]; DNA binding site 562970004771 Transcriptional regulators [Transcription]; Region: FadR; COG2186 562970004772 FCD domain; Region: FCD; pfam07729 562970004773 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 562970004774 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 562970004775 dimer interface [polypeptide binding]; other site 562970004776 active site 562970004777 catalytic residue [active] 562970004778 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 562970004779 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 562970004780 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 562970004781 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 562970004782 NAD binding site [chemical binding]; other site 562970004783 catalytic residues [active] 562970004784 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 562970004785 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 562970004786 putative ligand binding site [chemical binding]; other site 562970004787 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970004788 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 562970004789 TM-ABC transporter signature motif; other site 562970004790 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970004791 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 562970004792 TM-ABC transporter signature motif; other site 562970004793 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 562970004794 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 562970004795 Walker A/P-loop; other site 562970004796 ATP binding site [chemical binding]; other site 562970004797 Q-loop/lid; other site 562970004798 ABC transporter signature motif; other site 562970004799 Walker B; other site 562970004800 D-loop; other site 562970004801 H-loop/switch region; other site 562970004802 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 562970004803 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 562970004804 Walker A/P-loop; other site 562970004805 ATP binding site [chemical binding]; other site 562970004806 Q-loop/lid; other site 562970004807 ABC transporter signature motif; other site 562970004808 Walker B; other site 562970004809 D-loop; other site 562970004810 H-loop/switch region; other site 562970004811 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 562970004812 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 562970004813 TPP-binding site [chemical binding]; other site 562970004814 tetramer interface [polypeptide binding]; other site 562970004815 heterodimer interface [polypeptide binding]; other site 562970004816 phosphorylation loop region [posttranslational modification] 562970004817 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 562970004818 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 562970004819 alpha subunit interface [polypeptide binding]; other site 562970004820 TPP binding site [chemical binding]; other site 562970004821 heterodimer interface [polypeptide binding]; other site 562970004822 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970004823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 562970004824 YheO-like PAS domain; Region: PAS_6; pfam08348 562970004825 HTH domain; Region: HTH_22; pfam13309 562970004826 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 562970004827 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 562970004828 NAD(P) binding site [chemical binding]; other site 562970004829 homotetramer interface [polypeptide binding]; other site 562970004830 homodimer interface [polypeptide binding]; other site 562970004831 active site 562970004832 Transcriptional regulator PadR-like family; Region: PadR; cl17335 562970004833 Predicted transcriptional regulators [Transcription]; Region: COG1695 562970004834 polyhydroxyalkanoic acid synthase, PhaR subunit; Region: phaR_Bmeg; TIGR02132 562970004835 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 562970004836 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 562970004837 NAD(P) binding site [chemical binding]; other site 562970004838 homotetramer interface [polypeptide binding]; other site 562970004839 homodimer interface [polypeptide binding]; other site 562970004840 active site 562970004841 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 562970004842 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 562970004843 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 562970004844 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 562970004845 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 562970004846 active site 562970004847 YlzJ-like protein; Region: YlzJ; pfam14035 562970004848 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 562970004849 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970004850 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 562970004851 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 562970004852 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 562970004853 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 562970004854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970004855 non-specific DNA binding site [nucleotide binding]; other site 562970004856 salt bridge; other site 562970004857 sequence-specific DNA binding site [nucleotide binding]; other site 562970004858 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 562970004859 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 562970004860 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 562970004861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 562970004862 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 562970004863 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 562970004864 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 562970004865 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970004866 FeS/SAM binding site; other site 562970004867 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 562970004868 competence damage-inducible protein A; Provisional; Region: PRK00549 562970004869 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 562970004870 putative MPT binding site; other site 562970004871 Competence-damaged protein; Region: CinA; pfam02464 562970004872 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 562970004873 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 562970004874 ATP binding site [chemical binding]; other site 562970004875 Mg++ binding site [ion binding]; other site 562970004876 motif III; other site 562970004877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970004878 nucleotide binding region [chemical binding]; other site 562970004879 ATP-binding site [chemical binding]; other site 562970004880 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 562970004881 RNA binding site [nucleotide binding]; other site 562970004882 recombinase A; Provisional; Region: recA; PRK09354 562970004883 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 562970004884 hexamer interface [polypeptide binding]; other site 562970004885 Walker A motif; other site 562970004886 ATP binding site [chemical binding]; other site 562970004887 Walker B motif; other site 562970004888 RecX family; Region: RecX; cl00936 562970004889 phosphodiesterase; Provisional; Region: PRK12704 562970004890 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970004891 Zn2+ binding site [ion binding]; other site 562970004892 Mg2+ binding site [ion binding]; other site 562970004893 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 562970004894 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 562970004895 putative active site [active] 562970004896 metal binding site [ion binding]; metal-binding site 562970004897 homodimer binding site [polypeptide binding]; other site 562970004898 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 562970004899 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 562970004900 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 562970004901 active site 562970004902 dimer interface [polypeptide binding]; other site 562970004903 Outer spore coat protein E (CotE); Region: CotE; pfam10628 562970004904 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 562970004905 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 562970004906 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 562970004907 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 562970004908 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 562970004909 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 562970004910 PLD-like domain; Region: PLDc_2; pfam13091 562970004911 putative active site [active] 562970004912 catalytic site [active] 562970004913 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 562970004914 PLD-like domain; Region: PLDc_2; pfam13091 562970004915 putative active site [active] 562970004916 catalytic site [active] 562970004917 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970004918 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970004919 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 562970004920 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 562970004921 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970004922 FeS/SAM binding site; other site 562970004923 TRAM domain; Region: TRAM; cl01282 562970004924 Protein of unknown function (DUF964); Region: DUF964; pfam06133 562970004925 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 562970004926 MutS domain I; Region: MutS_I; pfam01624 562970004927 MutS domain III; Region: MutS_III; pfam05192 562970004928 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 562970004929 Walker A/P-loop; other site 562970004930 ATP binding site [chemical binding]; other site 562970004931 Q-loop/lid; other site 562970004932 ABC transporter signature motif; other site 562970004933 Walker B; other site 562970004934 D-loop; other site 562970004935 H-loop/switch region; other site 562970004936 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 562970004937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970004938 ATP binding site [chemical binding]; other site 562970004939 Mg2+ binding site [ion binding]; other site 562970004940 G-X-G motif; other site 562970004941 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 562970004942 ATP binding site [chemical binding]; other site 562970004943 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 562970004944 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 562970004945 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 562970004946 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 562970004947 bacterial Hfq-like; Region: Hfq; cd01716 562970004948 hexamer interface [polypeptide binding]; other site 562970004949 Sm1 motif; other site 562970004950 RNA binding site [nucleotide binding]; other site 562970004951 Sm2 motif; other site 562970004952 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 562970004953 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 562970004954 Domain of unknown function (DUF3870); Region: DUF3870; pfam12986 562970004955 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970004956 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 562970004957 TM-ABC transporter signature motif; other site 562970004958 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970004959 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 562970004960 TM-ABC transporter signature motif; other site 562970004961 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 562970004962 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 562970004963 Walker A/P-loop; other site 562970004964 ATP binding site [chemical binding]; other site 562970004965 Q-loop/lid; other site 562970004966 ABC transporter signature motif; other site 562970004967 Walker B; other site 562970004968 D-loop; other site 562970004969 H-loop/switch region; other site 562970004970 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 562970004971 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 562970004972 Walker A/P-loop; other site 562970004973 ATP binding site [chemical binding]; other site 562970004974 Q-loop/lid; other site 562970004975 ABC transporter signature motif; other site 562970004976 Walker B; other site 562970004977 D-loop; other site 562970004978 H-loop/switch region; other site 562970004979 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 562970004980 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 562970004981 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 562970004982 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 562970004983 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 562970004984 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 562970004985 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 562970004986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 562970004987 stage V sporulation protein K; Region: spore_V_K; TIGR02881 562970004988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970004989 Walker A motif; other site 562970004990 ATP binding site [chemical binding]; other site 562970004991 Walker B motif; other site 562970004992 arginine finger; other site 562970004993 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 562970004994 G3 box; other site 562970004995 Switch II region; other site 562970004996 GTP/Mg2+ binding site [chemical binding]; other site 562970004997 G4 box; other site 562970004998 G5 box; other site 562970004999 Aluminium resistance protein; Region: Alum_res; pfam06838 562970005000 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 562970005001 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 562970005002 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 562970005003 DNA binding residues [nucleotide binding] 562970005004 glutamine synthetase, type I; Region: GlnA; TIGR00653 562970005005 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 562970005006 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 562970005007 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 562970005008 Cytochrome c; Region: Cytochrom_C; pfam00034 562970005009 LexA repressor; Validated; Region: PRK00215 562970005010 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970005011 putative DNA binding site [nucleotide binding]; other site 562970005012 putative Zn2+ binding site [ion binding]; other site 562970005013 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 562970005014 Catalytic site [active] 562970005015 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970005016 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 562970005017 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970005018 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970005019 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970005020 DNA binding residues [nucleotide binding] 562970005021 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970005022 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970005023 catalytic residues [active] 562970005024 catalytic nucleophile [active] 562970005025 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 562970005026 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 562970005027 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 562970005028 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 562970005029 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 562970005030 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 562970005031 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 562970005032 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 562970005033 [4Fe-4S] binding site [ion binding]; other site 562970005034 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 562970005035 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 562970005036 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 562970005037 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 562970005038 molybdopterin cofactor binding site; other site 562970005039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970005040 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 562970005041 putative substrate translocation pore; other site 562970005042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 562970005043 Transposase; Region: HTH_Tnp_1; pfam01527 562970005044 putative transposase OrfB; Reviewed; Region: PHA02517 562970005045 HTH-like domain; Region: HTH_21; pfam13276 562970005046 Integrase core domain; Region: rve; pfam00665 562970005047 Integrase core domain; Region: rve_3; pfam13683 562970005048 NifZ domain; Region: NifZ; pfam04319 562970005049 amino acid transporter; Region: 2A0306; TIGR00909 562970005050 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 562970005051 Moco binding site; other site 562970005052 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 562970005053 metal coordination site [ion binding]; other site 562970005054 Uncharacterized conserved protein [Function unknown]; Region: COG1262 562970005055 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 562970005056 Protein of unknown function (DUF2000); Region: DUF2000; pfam09391 562970005057 Prephenate dehydratase; Region: PDT; pfam00800 562970005058 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 562970005059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970005060 DNA-binding site [nucleotide binding]; DNA binding site 562970005061 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 562970005062 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970005063 homodimer interface [polypeptide binding]; other site 562970005064 catalytic residue [active] 562970005065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 562970005066 Transposase; Region: HTH_Tnp_1; cl17663 562970005067 HTH-like domain; Region: HTH_21; pfam13276 562970005068 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 562970005069 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 562970005070 active site 562970005071 DNA binding site [nucleotide binding] 562970005072 Int/Topo IB signature motif; other site 562970005073 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 562970005074 Putative transposase; Region: Y2_Tnp; pfam04986 562970005075 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 562970005076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970005077 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 562970005078 Walker A/P-loop; other site 562970005079 ATP binding site [chemical binding]; other site 562970005080 Q-loop/lid; other site 562970005081 ABC transporter signature motif; other site 562970005082 Walker B; other site 562970005083 D-loop; other site 562970005084 H-loop/switch region; other site 562970005085 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 562970005086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970005087 dimer interface [polypeptide binding]; other site 562970005088 conserved gate region; other site 562970005089 putative PBP binding loops; other site 562970005090 ABC-ATPase subunit interface; other site 562970005091 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 562970005092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 562970005093 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 562970005094 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970005095 non-specific DNA binding site [nucleotide binding]; other site 562970005096 salt bridge; other site 562970005097 sequence-specific DNA binding site [nucleotide binding]; other site 562970005098 PBP superfamily domain; Region: PBP_like; pfam12727 562970005099 4Fe-4S binding domain; Region: Fer4; pfam00037 562970005100 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 562970005101 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 562970005102 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 562970005103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970005104 Walker A motif; other site 562970005105 ATP binding site [chemical binding]; other site 562970005106 Walker B motif; other site 562970005107 arginine finger; other site 562970005108 Peptidase family M41; Region: Peptidase_M41; pfam01434 562970005109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 562970005110 Protein of unknown function (DUF4264); Region: DUF4264; pfam14084 562970005111 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 562970005112 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 562970005113 active site 562970005114 putative substrate binding pocket [chemical binding]; other site 562970005115 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 562970005116 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 562970005117 Domain of unknown function (DUF377); Region: DUF377; pfam04041 562970005118 Glycosyl hydrolase family 43 containing a domain of unknown function; Region: GH43_DUF377; cd08993 562970005119 active site 562970005120 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 562970005121 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 562970005122 CoA binding domain; Region: CoA_binding; pfam02629 562970005123 TPR repeat; Region: TPR_11; pfam13414 562970005124 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970005125 TPR motif; other site 562970005126 binding surface 562970005127 TPR repeat; Region: TPR_11; pfam13414 562970005128 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970005129 TPR motif; other site 562970005130 binding surface 562970005131 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970005132 binding surface 562970005133 TPR motif; other site 562970005134 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 562970005135 tetramerization interface [polypeptide binding]; other site 562970005136 active site 562970005137 pantoate--beta-alanine ligase; Region: panC; TIGR00018 562970005138 Pantoate-beta-alanine ligase; Region: PanC; cd00560 562970005139 active site 562970005140 ATP-binding site [chemical binding]; other site 562970005141 pantoate-binding site; other site 562970005142 HXXH motif; other site 562970005143 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 562970005144 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 562970005145 active site 562970005146 oligomerization interface [polypeptide binding]; other site 562970005147 metal binding site [ion binding]; metal-binding site 562970005148 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970005149 putative DNA binding site [nucleotide binding]; other site 562970005150 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 562970005151 putative Zn2+ binding site [ion binding]; other site 562970005152 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 562970005153 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 562970005154 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 562970005155 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 562970005156 active site 562970005157 NTP binding site [chemical binding]; other site 562970005158 metal binding triad [ion binding]; metal-binding site 562970005159 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 562970005160 dihydrodipicolinate reductase; Provisional; Region: PRK00048 562970005161 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 562970005162 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 562970005163 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 562970005164 homodimer interface [polypeptide binding]; other site 562970005165 metal binding site [ion binding]; metal-binding site 562970005166 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 562970005167 Bacitracin resistance protein BacA; Region: BacA; pfam02673 562970005168 Uncharacterized membrane protein [Function unknown]; Region: COG3949 562970005169 Uncharacterized conserved protein [Function unknown]; Region: COG1284 562970005170 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 562970005171 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 562970005172 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 562970005173 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 562970005174 interchain domain interface [polypeptide binding]; other site 562970005175 intrachain domain interface; other site 562970005176 Qi binding site; other site 562970005177 Qo binding site; other site 562970005178 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 562970005179 Cytochrome c; Region: Cytochrom_C; pfam00034 562970005180 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 562970005181 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 562970005182 Qi binding site; other site 562970005183 intrachain domain interface; other site 562970005184 interchain domain interface [polypeptide binding]; other site 562970005185 heme bH binding site [chemical binding]; other site 562970005186 heme bL binding site [chemical binding]; other site 562970005187 Qo binding site; other site 562970005188 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 562970005189 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 562970005190 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 562970005191 iron-sulfur cluster [ion binding]; other site 562970005192 [2Fe-2S] cluster binding site [ion binding]; other site 562970005193 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cl10030 562970005194 hypothetical protein; Provisional; Region: PRK03636 562970005195 UPF0302 domain; Region: UPF0302; pfam08864 562970005196 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 562970005197 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 562970005198 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 562970005199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970005200 ATP binding site [chemical binding]; other site 562970005201 putative Mg++ binding site [ion binding]; other site 562970005202 nucleotide binding region [chemical binding]; other site 562970005203 helicase superfamily c-terminal domain; Region: HELICc; smart00490 562970005204 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 562970005205 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 562970005206 putative ligand binding site [chemical binding]; other site 562970005207 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970005208 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 562970005209 TM-ABC transporter signature motif; other site 562970005210 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 562970005211 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 562970005212 TM-ABC transporter signature motif; other site 562970005213 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 562970005214 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 562970005215 Walker A/P-loop; other site 562970005216 ATP binding site [chemical binding]; other site 562970005217 Q-loop/lid; other site 562970005218 ABC transporter signature motif; other site 562970005219 Walker B; other site 562970005220 D-loop; other site 562970005221 H-loop/switch region; other site 562970005222 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 562970005223 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 562970005224 Walker A/P-loop; other site 562970005225 ATP binding site [chemical binding]; other site 562970005226 Q-loop/lid; other site 562970005227 ABC transporter signature motif; other site 562970005228 Walker B; other site 562970005229 D-loop; other site 562970005230 H-loop/switch region; other site 562970005231 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 562970005232 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 562970005233 hinge; other site 562970005234 active site 562970005235 prephenate dehydrogenase; Validated; Region: PRK06545 562970005236 prephenate dehydrogenase; Validated; Region: PRK08507 562970005237 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 562970005238 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 562970005239 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 562970005240 substrate binding site [chemical binding]; other site 562970005241 active site 562970005242 catalytic residues [active] 562970005243 heterodimer interface [polypeptide binding]; other site 562970005244 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 562970005245 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 562970005246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970005247 catalytic residue [active] 562970005248 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 562970005249 active site 562970005250 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 562970005251 active site 562970005252 ribulose/triose binding site [chemical binding]; other site 562970005253 phosphate binding site [ion binding]; other site 562970005254 substrate (anthranilate) binding pocket [chemical binding]; other site 562970005255 product (indole) binding pocket [chemical binding]; other site 562970005256 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 562970005257 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 562970005258 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 562970005259 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 562970005260 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 562970005261 active site 562970005262 dimer interface [polypeptide binding]; other site 562970005263 metal binding site [ion binding]; metal-binding site 562970005264 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 562970005265 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 562970005266 Tetramer interface [polypeptide binding]; other site 562970005267 active site 562970005268 FMN-binding site [chemical binding]; other site 562970005269 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 562970005270 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 562970005271 active site 562970005272 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 562970005273 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 562970005274 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 562970005275 catalytic residues [active] 562970005276 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970005277 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970005278 active site 562970005279 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970005280 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970005281 active site 562970005282 acyl-CoA synthetase; Validated; Region: PRK08316 562970005283 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970005284 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 562970005285 acyl-activating enzyme (AAE) consensus motif; other site 562970005286 acyl-activating enzyme (AAE) consensus motif; other site 562970005287 putative AMP binding site [chemical binding]; other site 562970005288 putative active site [active] 562970005289 putative CoA binding site [chemical binding]; other site 562970005290 CoA binding site [chemical binding]; other site 562970005291 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 562970005292 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 562970005293 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 562970005294 MoaC_like Similar to the MaoC (monoamine oxidase C) dehydratase regulatory protein but without the N-terminal PutA domain. This protein family has a hot-dog fold similar to that of (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: MaoC_like; cd03446 562970005295 homodimer interaction site [polypeptide binding]; other site 562970005296 putative active site [active] 562970005297 putative catalytic site [active] 562970005298 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 562970005299 CoenzymeA binding site [chemical binding]; other site 562970005300 subunit interaction site [polypeptide binding]; other site 562970005301 PHB binding site; other site 562970005302 Domain of unknown function (DUF4009); Region: DUF4009; pfam13193 562970005303 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 562970005304 enoyl-CoA hydratase; Provisional; Region: PRK05995 562970005305 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970005306 substrate binding site [chemical binding]; other site 562970005307 oxyanion hole (OAH) forming residues; other site 562970005308 trimer interface [polypeptide binding]; other site 562970005309 Staphylococcal nuclease homologues; Region: SNc; smart00318 562970005310 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 562970005311 Catalytic site; other site 562970005312 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 562970005313 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970005314 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 562970005315 Transposase; Region: HTH_Tnp_1; pfam01527 562970005316 putative transposase OrfB; Reviewed; Region: PHA02517 562970005317 HTH-like domain; Region: HTH_21; pfam13276 562970005318 Integrase core domain; Region: rve; pfam00665 562970005319 Integrase core domain; Region: rve_3; pfam13683 562970005320 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 562970005321 Mrr N-terminal domain; Region: Mrr_N; pfam14338 562970005322 Restriction endonuclease; Region: Mrr_cat; pfam04471 562970005323 Protein of unknown function DUF45; Region: DUF45; pfam01863 562970005324 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 562970005325 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 562970005326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970005327 ATP binding site [chemical binding]; other site 562970005328 putative Mg++ binding site [ion binding]; other site 562970005329 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 562970005330 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 562970005331 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 562970005332 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 562970005333 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 562970005334 HsdM N-terminal domain; Region: HsdM_N; pfam12161 562970005335 Methyltransferase domain; Region: Methyltransf_26; pfam13659 562970005336 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970005337 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970005338 putative active site [active] 562970005339 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 562970005340 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 562970005341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970005342 S-adenosylmethionine binding site [chemical binding]; other site 562970005343 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 562970005344 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 562970005345 nucleophile elbow; other site 562970005346 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 562970005347 active site 562970005348 multimer interface [polypeptide binding]; other site 562970005349 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 562970005350 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 562970005351 substrate binding pocket [chemical binding]; other site 562970005352 chain length determination region; other site 562970005353 substrate-Mg2+ binding site; other site 562970005354 catalytic residues [active] 562970005355 aspartate-rich region 1; other site 562970005356 active site lid residues [active] 562970005357 aspartate-rich region 2; other site 562970005358 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 562970005359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970005360 FeS/SAM binding site; other site 562970005361 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 562970005362 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 562970005363 aromatic acid decarboxylase; Validated; Region: PRK05920 562970005364 Flavoprotein; Region: Flavoprotein; pfam02441 562970005365 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 562970005366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970005367 S-adenosylmethionine binding site [chemical binding]; other site 562970005368 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 562970005369 transcription attenuation protein MtrB; Provisional; Region: PRK13251 562970005370 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 562970005371 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 562970005372 active site 562970005373 acyl-activating enzyme (AAE) consensus motif; other site 562970005374 putative CoA binding site [chemical binding]; other site 562970005375 AMP binding site [chemical binding]; other site 562970005376 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 562970005377 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 562970005378 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 562970005379 glycine cleavage system protein H; Provisional; Region: PRK13380 562970005380 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 562970005381 lipoyl attachment site [posttranslational modification]; other site 562970005382 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 562970005383 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 562970005384 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 562970005385 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 562970005386 GTP-binding protein Der; Reviewed; Region: PRK00093 562970005387 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 562970005388 G1 box; other site 562970005389 GTP/Mg2+ binding site [chemical binding]; other site 562970005390 Switch I region; other site 562970005391 G2 box; other site 562970005392 Switch II region; other site 562970005393 G3 box; other site 562970005394 G4 box; other site 562970005395 G5 box; other site 562970005396 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 562970005397 G1 box; other site 562970005398 GTP/Mg2+ binding site [chemical binding]; other site 562970005399 Switch I region; other site 562970005400 G2 box; other site 562970005401 G3 box; other site 562970005402 Switch II region; other site 562970005403 G4 box; other site 562970005404 G5 box; other site 562970005405 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 562970005406 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 562970005407 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 562970005408 RNA binding site [nucleotide binding]; other site 562970005409 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 562970005410 RNA binding site [nucleotide binding]; other site 562970005411 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 562970005412 RNA binding site [nucleotide binding]; other site 562970005413 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 562970005414 RNA binding site [nucleotide binding]; other site 562970005415 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 562970005416 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 562970005417 putative acyl-acceptor binding pocket; other site 562970005418 cytidylate kinase; Provisional; Region: cmk; PRK00023 562970005419 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 562970005420 CMP-binding site; other site 562970005421 The sites determining sugar specificity; other site 562970005422 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 562970005423 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 562970005424 active site 562970005425 metal binding site [ion binding]; metal-binding site 562970005426 germination protein YpeB; Region: spore_YpeB; TIGR02889 562970005427 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 562970005428 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 562970005429 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 562970005430 Glycosyltransferase family 29 (sialyltransferase); Region: Glyco_transf_29; pfam00777 562970005431 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 562970005432 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 562970005433 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 562970005434 NAD(P) binding site [chemical binding]; other site 562970005435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970005436 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970005437 putative substrate translocation pore; other site 562970005438 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 562970005439 Protein of unknown function (DUF441); Region: DUF441; pfam04284 562970005440 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 562970005441 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 562970005442 Part of AAA domain; Region: AAA_19; pfam13245 562970005443 Family description; Region: UvrD_C_2; pfam13538 562970005444 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 562970005445 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 562970005446 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 562970005447 putative active site [active] 562970005448 putative metal binding site [ion binding]; other site 562970005449 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 562970005450 homodecamer interface [polypeptide binding]; other site 562970005451 GTP cyclohydrolase I; Provisional; Region: PLN03044 562970005452 active site 562970005453 putative catalytic site residues [active] 562970005454 zinc binding site [ion binding]; other site 562970005455 GTP-CH-I/GFRP interaction surface; other site 562970005456 Transglycosylase; Region: Transgly; pfam00912 562970005457 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 562970005458 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 562970005459 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 562970005460 Interdomain contacts; other site 562970005461 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 562970005462 DNA-binding site [nucleotide binding]; DNA binding site 562970005463 RNA-binding motif; other site 562970005464 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 562970005465 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 562970005466 active site 562970005467 dimer interface [polypeptide binding]; other site 562970005468 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 562970005469 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 562970005470 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 562970005471 active site 562970005472 FMN binding site [chemical binding]; other site 562970005473 substrate binding site [chemical binding]; other site 562970005474 3Fe-4S cluster binding site [ion binding]; other site 562970005475 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 562970005476 domain_subunit interface; other site 562970005477 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 562970005478 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 562970005479 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970005480 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970005481 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 562970005482 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 562970005483 putative active site [active] 562970005484 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 562970005485 interface (dimer of trimers) [polypeptide binding]; other site 562970005486 multifunctional aminopeptidase A; Provisional; Region: PRK00913 562970005487 Substrate-binding/catalytic site; other site 562970005488 Zn-binding sites [ion binding]; other site 562970005489 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 562970005490 Protein of unknown function (DUF466); Region: DUF466; cl01082 562970005491 carbon starvation protein A; Provisional; Region: PRK15015 562970005492 Carbon starvation protein CstA; Region: CstA; pfam02554 562970005493 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 562970005494 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 562970005495 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 562970005496 ligand binding site [chemical binding]; other site 562970005497 NAD binding site [chemical binding]; other site 562970005498 dimerization interface [polypeptide binding]; other site 562970005499 catalytic site [active] 562970005500 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 562970005501 putative L-serine binding site [chemical binding]; other site 562970005502 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 562970005503 ThiS interaction site; other site 562970005504 putative active site [active] 562970005505 tetramer interface [polypeptide binding]; other site 562970005506 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 562970005507 thiS-thiF/thiG interaction site; other site 562970005508 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 562970005509 thiamine phosphate binding site [chemical binding]; other site 562970005510 active site 562970005511 pyrophosphate binding site [ion binding]; other site 562970005512 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 562970005513 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 562970005514 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970005515 dimerization interface [polypeptide binding]; other site 562970005516 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 562970005517 PAS domain; Region: PAS; smart00091 562970005518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970005519 dimer interface [polypeptide binding]; other site 562970005520 phosphorylation site [posttranslational modification] 562970005521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970005522 ATP binding site [chemical binding]; other site 562970005523 Mg2+ binding site [ion binding]; other site 562970005524 G-X-G motif; other site 562970005525 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970005526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970005527 active site 562970005528 phosphorylation site [posttranslational modification] 562970005529 intermolecular recognition site; other site 562970005530 dimerization interface [polypeptide binding]; other site 562970005531 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970005532 DNA binding site [nucleotide binding] 562970005533 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 562970005534 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970005535 RNA binding surface [nucleotide binding]; other site 562970005536 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 562970005537 active site 562970005538 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 562970005539 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 562970005540 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 562970005541 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 562970005542 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 562970005543 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 562970005544 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 562970005545 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 562970005546 ScpA/B protein; Region: ScpA_ScpB; cl00598 562970005547 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 562970005548 Peptidase family M50; Region: Peptidase_M50; pfam02163 562970005549 active site 562970005550 putative substrate binding region [chemical binding]; other site 562970005551 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 562970005552 homopentamer interface [polypeptide binding]; other site 562970005553 active site 562970005554 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 562970005555 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 562970005556 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 562970005557 dimerization interface [polypeptide binding]; other site 562970005558 active site 562970005559 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 562970005560 Lumazine binding domain; Region: Lum_binding; pfam00677 562970005561 Lumazine binding domain; Region: Lum_binding; pfam00677 562970005562 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 562970005563 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 562970005564 catalytic motif [active] 562970005565 Zn binding site [ion binding]; other site 562970005566 RibD C-terminal domain; Region: RibD_C; cl17279 562970005567 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 562970005568 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 562970005569 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 562970005570 diaminopimelate decarboxylase; Region: lysA; TIGR01048 562970005571 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 562970005572 active site 562970005573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 562970005574 substrate binding site [chemical binding]; other site 562970005575 catalytic residues [active] 562970005576 dimer interface [polypeptide binding]; other site 562970005577 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 562970005578 stage V sporulation protein AD; Validated; Region: PRK08304 562970005579 stage V sporulation protein AD; Provisional; Region: PRK12404 562970005580 SpoVA protein; Region: SpoVA; cl04298 562970005581 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 562970005582 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 562970005583 sporulation sigma factor SigF; Validated; Region: PRK05572 562970005584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970005585 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 562970005586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970005587 DNA binding residues [nucleotide binding] 562970005588 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 562970005589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970005590 ATP binding site [chemical binding]; other site 562970005591 Mg2+ binding site [ion binding]; other site 562970005592 G-X-G motif; other site 562970005593 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 562970005594 anti sigma factor interaction site; other site 562970005595 regulatory phosphorylation site [posttranslational modification]; other site 562970005596 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 562970005597 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 562970005598 Walker A/P-loop; other site 562970005599 ATP binding site [chemical binding]; other site 562970005600 Q-loop/lid; other site 562970005601 ABC transporter signature motif; other site 562970005602 Walker B; other site 562970005603 D-loop; other site 562970005604 H-loop/switch region; other site 562970005605 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 562970005606 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 562970005607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970005608 dimer interface [polypeptide binding]; other site 562970005609 conserved gate region; other site 562970005610 putative PBP binding loops; other site 562970005611 ABC-ATPase subunit interface; other site 562970005612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970005613 dimer interface [polypeptide binding]; other site 562970005614 conserved gate region; other site 562970005615 putative PBP binding loops; other site 562970005616 ABC-ATPase subunit interface; other site 562970005617 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 562970005618 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 562970005619 HIGH motif; other site 562970005620 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 562970005621 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 562970005622 active site 562970005623 KMSKS motif; other site 562970005624 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 562970005625 tRNA binding surface [nucleotide binding]; other site 562970005626 anticodon binding site; other site 562970005627 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 562970005628 DivIVA protein; Region: DivIVA; pfam05103 562970005629 DivIVA domain; Region: DivI1A_domain; TIGR03544 562970005630 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 562970005631 YGGT family; Region: YGGT; pfam02325 562970005632 Protein of unknown function (DUF552); Region: DUF552; pfam04472 562970005633 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 562970005634 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 562970005635 catalytic residue [active] 562970005636 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 562970005637 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 562970005638 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 562970005639 sporulation sigma factor SigG; Reviewed; Region: PRK08215 562970005640 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970005641 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 562970005642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970005643 DNA binding residues [nucleotide binding] 562970005644 sporulation sigma factor SigE; Reviewed; Region: PRK08301 562970005645 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970005646 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970005647 DNA binding residues [nucleotide binding] 562970005648 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 562970005649 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 562970005650 cell division protein FtsZ; Validated; Region: PRK09330 562970005651 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 562970005652 nucleotide binding site [chemical binding]; other site 562970005653 SulA interaction site; other site 562970005654 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 562970005655 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 562970005656 nucleotide binding site [chemical binding]; other site 562970005657 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 562970005658 Cell division protein FtsA; Region: FtsA; pfam14450 562970005659 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 562970005660 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 562970005661 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 562970005662 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 562970005663 Cell division protein FtsQ; Region: FtsQ; pfam03799 562970005664 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 562970005665 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 562970005666 hinge; other site 562970005667 active site 562970005668 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 562970005669 FAD binding domain; Region: FAD_binding_4; pfam01565 562970005670 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 562970005671 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 562970005672 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 562970005673 active site 562970005674 homodimer interface [polypeptide binding]; other site 562970005675 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 562970005676 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 562970005677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970005678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970005679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 562970005680 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 562970005681 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 562970005682 Mg++ binding site [ion binding]; other site 562970005683 putative catalytic motif [active] 562970005684 putative substrate binding site [chemical binding]; other site 562970005685 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 562970005686 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 562970005687 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970005688 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 562970005689 Ferritin-like; Region: Ferritin-like; pfam12902 562970005690 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 562970005691 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 562970005692 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 562970005693 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 562970005694 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 562970005695 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 562970005696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 562970005697 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 562970005698 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 562970005699 Cell division protein FtsL; Region: FtsL; cl11433 562970005700 MraW methylase family; Region: Methyltransf_5; cl17771 562970005701 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 562970005702 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 562970005703 MraZ protein; Region: MraZ; pfam02381 562970005704 MraZ protein; Region: MraZ; pfam02381 562970005705 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 562970005706 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 562970005707 Malonate decarboxylase gamma subunit (MdcE); Region: MdcE; cl17835 562970005708 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 562970005709 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 562970005710 active site 562970005711 catalytic residues [active] 562970005712 metal binding site [ion binding]; metal-binding site 562970005713 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 562970005714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970005715 NAD(P) binding site [chemical binding]; other site 562970005716 active site 562970005717 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 562970005718 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 562970005719 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 562970005720 G1 box; other site 562970005721 putative GEF interaction site [polypeptide binding]; other site 562970005722 GTP/Mg2+ binding site [chemical binding]; other site 562970005723 Switch I region; other site 562970005724 G2 box; other site 562970005725 G3 box; other site 562970005726 Switch II region; other site 562970005727 G4 box; other site 562970005728 G5 box; other site 562970005729 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 562970005730 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 562970005731 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 562970005732 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970005733 motif II; other site 562970005734 Predicted transcriptional regulators [Transcription]; Region: COG1733 562970005735 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970005736 dimerization interface [polypeptide binding]; other site 562970005737 putative DNA binding site [nucleotide binding]; other site 562970005738 putative Zn2+ binding site [ion binding]; other site 562970005739 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 562970005740 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 562970005741 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 562970005742 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 562970005743 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 562970005744 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 562970005745 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 562970005746 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 562970005747 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 562970005748 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 562970005749 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005750 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005751 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005752 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005753 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005754 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005755 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 562970005756 S-layer homology domain; Region: SLH; pfam00395 562970005757 S-layer homology domain; Region: SLH; pfam00395 562970005758 S-layer homology domain; Region: SLH; pfam00395 562970005759 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970005760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970005761 active site 562970005762 phosphorylation site [posttranslational modification] 562970005763 intermolecular recognition site; other site 562970005764 dimerization interface [polypeptide binding]; other site 562970005765 pyruvate carboxylase; Reviewed; Region: PRK12999 562970005766 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970005767 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 562970005768 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 562970005769 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 562970005770 active site 562970005771 catalytic residues [active] 562970005772 metal binding site [ion binding]; metal-binding site 562970005773 homodimer binding site [polypeptide binding]; other site 562970005774 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 562970005775 carboxyltransferase (CT) interaction site; other site 562970005776 biotinylation site [posttranslational modification]; other site 562970005777 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 562970005778 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 562970005779 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 562970005780 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 562970005781 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 562970005782 Ligand Binding Site [chemical binding]; other site 562970005783 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 562970005784 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 562970005785 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970005786 catalytic residue [active] 562970005787 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970005788 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 562970005789 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 562970005790 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 562970005791 Uncharacterized conserved protein [Function unknown]; Region: COG1565 562970005792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 562970005793 Clp protease; Region: CLP_protease; pfam00574 562970005794 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 562970005795 oligomer interface [polypeptide binding]; other site 562970005796 active site residues [active] 562970005797 Isochorismatase family; Region: Isochorismatase; pfam00857 562970005798 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 562970005799 catalytic triad [active] 562970005800 conserved cis-peptide bond; other site 562970005801 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 562970005802 IDEAL domain; Region: IDEAL; cl07452 562970005803 Protein of unknown function (DUF964); Region: DUF964; pfam06133 562970005804 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 562970005805 CpXC protein; Region: CpXC; pfam14353 562970005806 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 562970005807 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 562970005808 active site 562970005809 dimer interface [polypeptide binding]; other site 562970005810 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 562970005811 dimer interface [polypeptide binding]; other site 562970005812 active site 562970005813 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 562970005814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970005815 NAD(P) binding site [chemical binding]; other site 562970005816 active site 562970005817 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 562970005818 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 562970005819 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 562970005820 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 562970005821 catalytic triad [active] 562970005822 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 562970005823 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 562970005824 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 562970005825 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 562970005826 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 562970005827 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 562970005828 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 562970005829 glutamine binding [chemical binding]; other site 562970005830 catalytic triad [active] 562970005831 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 562970005832 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 562970005833 dimerization interface [polypeptide binding]; other site 562970005834 DPS ferroxidase diiron center [ion binding]; other site 562970005835 ion pore; other site 562970005836 ferric uptake regulator; Provisional; Region: fur; PRK09462 562970005837 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 562970005838 metal binding site 2 [ion binding]; metal-binding site 562970005839 putative DNA binding helix; other site 562970005840 metal binding site 1 [ion binding]; metal-binding site 562970005841 dimer interface [polypeptide binding]; other site 562970005842 structural Zn2+ binding site [ion binding]; other site 562970005843 3D domain; Region: 3D; cl01439 562970005844 stage V sporulation protein AD; Validated; Region: PRK08304 562970005845 stage V sporulation protein AD; Provisional; Region: PRK12404 562970005846 SpoVA protein; Region: SpoVA; cl04298 562970005847 Predicted membrane protein [Function unknown]; Region: COG2323 562970005848 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 562970005849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970005850 dimerization interface [polypeptide binding]; other site 562970005851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970005852 dimer interface [polypeptide binding]; other site 562970005853 phosphorylation site [posttranslational modification] 562970005854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970005855 ATP binding site [chemical binding]; other site 562970005856 Mg2+ binding site [ion binding]; other site 562970005857 G-X-G motif; other site 562970005858 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970005859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970005860 active site 562970005861 phosphorylation site [posttranslational modification] 562970005862 intermolecular recognition site; other site 562970005863 dimerization interface [polypeptide binding]; other site 562970005864 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970005865 DNA binding site [nucleotide binding] 562970005866 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 562970005867 CotJB protein; Region: CotJB; pfam12652 562970005868 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 562970005869 Uncharacterized conserved protein [Function unknown]; Region: COG1633 562970005870 dimanganese center [ion binding]; other site 562970005871 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 562970005872 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 562970005873 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 562970005874 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 562970005875 active site 562970005876 catalytic triad [active] 562970005877 oxyanion hole [active] 562970005878 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 562970005879 endonuclease IV; Provisional; Region: PRK01060 562970005880 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 562970005881 AP (apurinic/apyrimidinic) site pocket; other site 562970005882 DNA interaction; other site 562970005883 Metal-binding active site; metal-binding site 562970005884 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 562970005885 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 562970005886 active site 562970005887 metal binding site [ion binding]; metal-binding site 562970005888 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 562970005889 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 562970005890 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970005891 inhibitor-cofactor binding pocket; inhibition site 562970005892 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970005893 catalytic residue [active] 562970005894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970005895 non-specific DNA binding site [nucleotide binding]; other site 562970005896 salt bridge; other site 562970005897 sequence-specific DNA binding site [nucleotide binding]; other site 562970005898 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 562970005899 polymerase nucleotide-binding site; other site 562970005900 DNA-binding residues [nucleotide binding]; DNA binding site 562970005901 nucleotide binding site [chemical binding]; other site 562970005902 primase nucleotide-binding site [nucleotide binding]; other site 562970005903 Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708 562970005904 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 562970005905 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 562970005906 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970005907 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 562970005908 DNA binding residues [nucleotide binding] 562970005909 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 562970005910 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 562970005911 active site 562970005912 DNA binding site [nucleotide binding] 562970005913 Int/Topo IB signature motif; other site 562970005914 Septum formation initiator; Region: DivIC; cl17659 562970005915 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 562970005916 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 562970005917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970005918 Walker A/P-loop; other site 562970005919 ATP binding site [chemical binding]; other site 562970005920 Q-loop/lid; other site 562970005921 ABC transporter signature motif; other site 562970005922 Walker B; other site 562970005923 D-loop; other site 562970005924 H-loop/switch region; other site 562970005925 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970005926 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 562970005927 TM-ABC transporter signature motif; other site 562970005928 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 562970005929 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 562970005930 zinc binding site [ion binding]; other site 562970005931 putative ligand binding site [chemical binding]; other site 562970005932 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 562970005933 DNA-binding site [nucleotide binding]; DNA binding site 562970005934 RNA-binding motif; other site 562970005935 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 562970005936 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 562970005937 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 562970005938 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 562970005939 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 562970005940 NodB motif; other site 562970005941 active site 562970005942 catalytic site [active] 562970005943 metal binding site [ion binding]; metal-binding site 562970005944 PAS domain; Region: PAS_8; pfam13188 562970005945 PAS domain; Region: PAS_9; pfam13426 562970005946 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 562970005947 Histidine kinase; Region: HisKA_3; pfam07730 562970005948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970005949 ATP binding site [chemical binding]; other site 562970005950 Mg2+ binding site [ion binding]; other site 562970005951 G-X-G motif; other site 562970005952 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970005953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970005954 active site 562970005955 phosphorylation site [posttranslational modification] 562970005956 intermolecular recognition site; other site 562970005957 dimerization interface [polypeptide binding]; other site 562970005958 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970005959 DNA binding residues [nucleotide binding] 562970005960 dimerization interface [polypeptide binding]; other site 562970005961 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970005962 Zn2+ binding site [ion binding]; other site 562970005963 Mg2+ binding site [ion binding]; other site 562970005964 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970005965 Zn2+ binding site [ion binding]; other site 562970005966 Mg2+ binding site [ion binding]; other site 562970005967 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 562970005968 Ligand Binding Site [chemical binding]; other site 562970005969 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 562970005970 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 562970005971 Walker A/P-loop; other site 562970005972 ATP binding site [chemical binding]; other site 562970005973 Q-loop/lid; other site 562970005974 ABC transporter signature motif; other site 562970005975 Walker B; other site 562970005976 D-loop; other site 562970005977 H-loop/switch region; other site 562970005978 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 562970005979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970005980 ABC-ATPase subunit interface; other site 562970005981 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 562970005982 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 562970005983 Uncharacterized conserved protein [Function unknown]; Region: COG0398 562970005984 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 562970005985 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 562970005986 metal-binding site [ion binding] 562970005987 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 562970005988 putative homodimer interface [polypeptide binding]; other site 562970005989 putative homotetramer interface [polypeptide binding]; other site 562970005990 putative allosteric switch controlling residues; other site 562970005991 putative metal binding site [ion binding]; other site 562970005992 putative homodimer-homodimer interface [polypeptide binding]; other site 562970005993 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 562970005994 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 562970005995 nucleotide binding site/active site [active] 562970005996 HIT family signature motif; other site 562970005997 catalytic residue [active] 562970005998 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 562970005999 classical (c) SDRs; Region: SDR_c; cd05233 562970006000 NAD(P) binding site [chemical binding]; other site 562970006001 active site 562970006002 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 562970006003 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 562970006004 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 562970006005 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 562970006006 active site 562970006007 Zn binding site [ion binding]; other site 562970006008 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 562970006009 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 562970006010 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 562970006011 catalytic residues [active] 562970006012 Protein of unknown function (DUF423); Region: DUF423; pfam04241 562970006013 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 562970006014 active site 562970006015 FMN binding site [chemical binding]; other site 562970006016 substrate binding site [chemical binding]; other site 562970006017 3Fe-4S cluster binding site [ion binding]; other site 562970006018 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 562970006019 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 562970006020 Coenzyme A binding pocket [chemical binding]; other site 562970006021 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 562970006022 CoA binding domain; Region: CoA_binding_2; pfam13380 562970006023 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 562970006024 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 562970006025 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 562970006026 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 562970006027 NAD(P) binding site [chemical binding]; other site 562970006028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970006029 dimerization interface [polypeptide binding]; other site 562970006030 putative DNA binding site [nucleotide binding]; other site 562970006031 putative Zn2+ binding site [ion binding]; other site 562970006032 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 562970006033 arsenical-resistance protein; Region: acr3; TIGR00832 562970006034 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 562970006035 Low molecular weight phosphatase family; Region: LMWPc; cd00115 562970006036 active site 562970006037 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 562970006038 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970006039 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 562970006040 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 562970006041 active site 562970006042 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 562970006043 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 562970006044 Cysteine-rich domain; Region: CCG; pfam02754 562970006045 Cysteine-rich domain; Region: CCG; pfam02754 562970006046 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 562970006047 Ligand Binding Site [chemical binding]; other site 562970006048 FAD binding domain; Region: FAD_binding_4; pfam01565 562970006049 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 562970006050 Transcriptional regulators [Transcription]; Region: FadR; COG2186 562970006051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970006052 DNA-binding site [nucleotide binding]; DNA binding site 562970006053 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 562970006054 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 562970006055 UbiA prenyltransferase family; Region: UbiA; pfam01040 562970006056 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 562970006057 active site 562970006058 catalytic site [active] 562970006059 substrate binding site [chemical binding]; other site 562970006060 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 562970006061 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 562970006062 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970006063 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970006064 active site 562970006065 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 562970006066 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 562970006067 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 562970006068 Isochorismatase family; Region: Isochorismatase; pfam00857 562970006069 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 562970006070 catalytic triad [active] 562970006071 conserved cis-peptide bond; other site 562970006072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 562970006073 NMT1/THI5 like; Region: NMT1; pfam09084 562970006074 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 562970006075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970006076 dimer interface [polypeptide binding]; other site 562970006077 conserved gate region; other site 562970006078 putative PBP binding loops; other site 562970006079 ABC-ATPase subunit interface; other site 562970006080 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 562970006081 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 562970006082 Walker A/P-loop; other site 562970006083 ATP binding site [chemical binding]; other site 562970006084 Q-loop/lid; other site 562970006085 ABC transporter signature motif; other site 562970006086 Walker B; other site 562970006087 D-loop; other site 562970006088 H-loop/switch region; other site 562970006089 Creatinine amidohydrolase; Region: Creatininase; pfam02633 562970006090 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 562970006091 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 562970006092 active site 562970006093 putative substrate binding pocket [chemical binding]; other site 562970006094 adenosine deaminase; Provisional; Region: PRK09358 562970006095 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 562970006096 active site 562970006097 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 562970006098 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970006099 catalytic loop [active] 562970006100 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 562970006101 iron binding site [ion binding]; other site 562970006102 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 562970006103 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 562970006104 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 562970006105 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 562970006106 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 562970006107 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970006108 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 562970006109 TM-ABC transporter signature motif; other site 562970006110 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970006111 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 562970006112 TM-ABC transporter signature motif; other site 562970006113 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 562970006114 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 562970006115 Walker A/P-loop; other site 562970006116 ATP binding site [chemical binding]; other site 562970006117 Q-loop/lid; other site 562970006118 ABC transporter signature motif; other site 562970006119 Walker B; other site 562970006120 D-loop; other site 562970006121 H-loop/switch region; other site 562970006122 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 562970006123 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 562970006124 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 562970006125 putative ligand binding site [chemical binding]; other site 562970006126 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 562970006127 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 562970006128 active site 562970006129 putative substrate binding pocket [chemical binding]; other site 562970006130 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 562970006131 active site 562970006132 homotetramer interface [polypeptide binding]; other site 562970006133 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 562970006134 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 562970006135 active site 562970006136 OHCU decarboxylase; Region: OHCU_decarbox; pfam09349 562970006137 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 562970006138 DRTGG domain; Region: DRTGG; pfam07085 562970006139 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 562970006140 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 562970006141 allantoate amidohydrolase; Reviewed; Region: PRK09290 562970006142 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 562970006143 active site 562970006144 metal binding site [ion binding]; metal-binding site 562970006145 dimer interface [polypeptide binding]; other site 562970006146 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 562970006147 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 562970006148 metal binding site [ion binding]; metal-binding site 562970006149 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 562970006150 allantoinase; Provisional; Region: PRK06189 562970006151 active site 562970006152 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 562970006153 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 562970006154 Nitrogen regulatory protein P-II; Region: P-II; smart00938 562970006155 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 562970006156 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 562970006157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 562970006158 Probable transposase; Region: OrfB_IS605; pfam01385 562970006159 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970006160 agmatinase; Region: agmatinase; TIGR01230 562970006161 Agmatinase-like family; Region: Agmatinase-like; cd09990 562970006162 active site 562970006163 oligomer interface [polypeptide binding]; other site 562970006164 Mn binding site [ion binding]; other site 562970006165 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 562970006166 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 562970006167 putative NAD(P) binding site [chemical binding]; other site 562970006168 dimer interface [polypeptide binding]; other site 562970006169 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 562970006170 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 562970006171 putative NAD(P) binding site [chemical binding]; other site 562970006172 Amidohydrolase; Region: Amidohydro_2; pfam04909 562970006173 active site 562970006174 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 562970006175 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970006176 dinuclear metal binding motif [ion binding]; other site 562970006177 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 562970006178 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 562970006179 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 562970006180 NAD binding site [chemical binding]; other site 562970006181 substrate binding site [chemical binding]; other site 562970006182 catalytic Zn binding site [ion binding]; other site 562970006183 tetramer interface [polypeptide binding]; other site 562970006184 structural Zn binding site [ion binding]; other site 562970006185 Protein of unknown function (DUF4242); Region: DUF4242; pfam14026 562970006186 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188 562970006187 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 562970006188 putative active site [active] 562970006189 metal binding site [ion binding]; metal-binding site 562970006190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 562970006191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970006192 dimer interface [polypeptide binding]; other site 562970006193 phosphorylation site [posttranslational modification] 562970006194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970006195 ATP binding site [chemical binding]; other site 562970006196 Mg2+ binding site [ion binding]; other site 562970006197 G-X-G motif; other site 562970006198 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 562970006199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970006200 active site 562970006201 phosphorylation site [posttranslational modification] 562970006202 intermolecular recognition site; other site 562970006203 dimerization interface [polypeptide binding]; other site 562970006204 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970006205 Walker A motif; other site 562970006206 ATP binding site [chemical binding]; other site 562970006207 Walker B motif; other site 562970006208 arginine finger; other site 562970006209 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970006210 PAS domain; Region: PAS_9; pfam13426 562970006211 putative active site [active] 562970006212 heme pocket [chemical binding]; other site 562970006213 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970006214 Zn2+ binding site [ion binding]; other site 562970006215 Mg2+ binding site [ion binding]; other site 562970006216 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 562970006217 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 562970006218 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 562970006219 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970006220 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970006221 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 562970006222 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 562970006223 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 562970006224 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 562970006225 heme-binding site [chemical binding]; other site 562970006226 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970006227 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970006228 dimer interface [polypeptide binding]; other site 562970006229 putative CheW interface [polypeptide binding]; other site 562970006230 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 562970006231 S-layer homology domain; Region: SLH; pfam00395 562970006232 S-layer homology domain; Region: SLH; pfam00395 562970006233 Probable transposase; Region: OrfB_IS605; pfam01385 562970006234 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970006235 Transposase IS200 like; Region: Y1_Tnp; pfam01797 562970006236 Fic family protein [Function unknown]; Region: COG3177 562970006237 Fic/DOC family; Region: Fic; pfam02661 562970006238 ATP-grasp domain; Region: ATP-grasp_4; cl17255 562970006239 Transcriptional regulators [Transcription]; Region: GntR; COG1802 562970006240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970006241 DNA-binding site [nucleotide binding]; DNA binding site 562970006242 FCD domain; Region: FCD; pfam07729 562970006243 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 562970006244 epoxyqueuosine reductase; Region: TIGR00276 562970006245 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 562970006246 Formaldehyde dehydrogenases; Region: FDH_like; cd05278 562970006247 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 562970006248 catalytic Zn binding site [ion binding]; other site 562970006249 NAD(P) binding site [chemical binding]; other site 562970006250 structural Zn binding site [ion binding]; other site 562970006251 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 562970006252 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970006253 catalytic loop [active] 562970006254 iron binding site [ion binding]; other site 562970006255 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 562970006256 FAD binding pocket [chemical binding]; other site 562970006257 conserved FAD binding motif [chemical binding]; other site 562970006258 phosphate binding motif [ion binding]; other site 562970006259 beta-alpha-beta structure motif; other site 562970006260 NAD binding pocket [chemical binding]; other site 562970006261 Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058 562970006262 dimerization interface [polypeptide binding]; other site 562970006263 MmoB/DmpM family; Region: MmoB_DmpM; pfam02406 562970006264 Toluene-4-monooxygenase effector protein complex (T4mo), Rieske ferredoxin subunit; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. T4mo is a four-protein complex that catalyzes the NADH- and O2-dependent...; Region: Rieske_T4moC; cd03474 562970006265 [2Fe-2S] cluster binding site [ion binding]; other site 562970006266 Toluene-4-monooxygenase system protein B (TmoB); Region: TmoB; pfam06234 562970006267 Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057 562970006268 dimerization interface [polypeptide binding]; other site 562970006269 putative path to active site cavity [active] 562970006270 diiron center [ion binding]; other site 562970006271 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 562970006272 N-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_N; cd07265 562970006273 tetramer interface [polypeptide binding]; other site 562970006274 C-terminal domain of catechol 2,3-dioxygenase; Region: 2_3_CTD_C; cd07243 562970006275 tetramer interface [polypeptide binding]; other site 562970006276 active site 562970006277 Fe binding site [ion binding]; other site 562970006278 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 562970006279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970006280 catalytic loop [active] 562970006281 iron binding site [ion binding]; other site 562970006282 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 562970006283 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 562970006284 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 562970006285 active site 1 [active] 562970006286 dimer interface [polypeptide binding]; other site 562970006287 hexamer interface [polypeptide binding]; other site 562970006288 active site 2 [active] 562970006289 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 562970006290 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 562970006291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 562970006292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 562970006293 Coenzyme A binding pocket [chemical binding]; other site 562970006294 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 562970006295 acetyl-CoA synthetase; Provisional; Region: PRK04319 562970006296 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 562970006297 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970006298 acyl-activating enzyme (AAE) consensus motif; other site 562970006299 AMP binding site [chemical binding]; other site 562970006300 active site 562970006301 CoA binding site [chemical binding]; other site 562970006302 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 562970006303 PGAP1-like protein; Region: PGAP1; pfam07819 562970006304 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 562970006305 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 562970006306 homodimer interface [polypeptide binding]; other site 562970006307 substrate-cofactor binding pocket; other site 562970006308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970006309 catalytic residue [active] 562970006310 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 562970006311 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 562970006312 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 562970006313 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 562970006314 Walker A/P-loop; other site 562970006315 ATP binding site [chemical binding]; other site 562970006316 Q-loop/lid; other site 562970006317 ABC transporter signature motif; other site 562970006318 Walker B; other site 562970006319 D-loop; other site 562970006320 H-loop/switch region; other site 562970006321 Protein of unknown function (DUF964); Region: DUF964; cl01483 562970006322 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 562970006323 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 562970006324 metal-binding site [ion binding] 562970006325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 562970006326 Soluble P-type ATPase [General function prediction only]; Region: COG4087 562970006327 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970006328 dimerization interface [polypeptide binding]; other site 562970006329 putative DNA binding site [nucleotide binding]; other site 562970006330 putative Zn2+ binding site [ion binding]; other site 562970006331 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 562970006332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 562970006333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 562970006334 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 562970006335 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 562970006336 Metal-binding active site; metal-binding site 562970006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970006338 dimer interface [polypeptide binding]; other site 562970006339 conserved gate region; other site 562970006340 putative PBP binding loops; other site 562970006341 ABC-ATPase subunit interface; other site 562970006342 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 562970006343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970006344 dimer interface [polypeptide binding]; other site 562970006345 conserved gate region; other site 562970006346 putative PBP binding loops; other site 562970006347 ABC-ATPase subunit interface; other site 562970006348 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 562970006349 putative active site [active] 562970006350 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 562970006351 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 562970006352 TIGR02679 family protein; Region: TIGR02679 562970006353 Protein of unknown function C-terminus (DUF2399); Region: DUF2399; pfam09664 562970006354 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 562970006355 non-specific DNA binding site [nucleotide binding]; other site 562970006356 salt bridge; other site 562970006357 sequence-specific DNA binding site [nucleotide binding]; other site 562970006358 HEPN domain; Region: HEPN; cl00824 562970006359 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970006360 sequence-specific DNA binding site [nucleotide binding]; other site 562970006361 salt bridge; other site 562970006362 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 562970006363 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 562970006364 dimerization interface [polypeptide binding]; other site 562970006365 DPS ferroxidase diiron center [ion binding]; other site 562970006366 ion pore; other site 562970006367 Helix-turn-helix domain; Region: HTH_28; pfam13518 562970006368 Winged helix-turn helix; Region: HTH_29; pfam13551 562970006369 Homeodomain-like domain; Region: HTH_32; pfam13565 562970006370 DDE superfamily endonuclease; Region: DDE_3; pfam13358 562970006371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 562970006372 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970006373 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 562970006374 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 562970006375 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 562970006376 Probable transposase; Region: OrfB_IS605; pfam01385 562970006377 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970006378 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970006379 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970006380 catalytic residues [active] 562970006381 catalytic nucleophile [active] 562970006382 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 562970006383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 562970006384 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 562970006385 Spore germination protein; Region: Spore_permease; cl17796 562970006386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 562970006387 Transposase; Region: HTH_Tnp_1; pfam01527 562970006388 putative transposase OrfB; Reviewed; Region: PHA02517 562970006389 HTH-like domain; Region: HTH_21; pfam13276 562970006390 Integrase core domain; Region: rve; pfam00665 562970006391 Integrase core domain; Region: rve_3; pfam13683 562970006392 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 562970006393 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 562970006394 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 562970006395 DXD motif; other site 562970006396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970006398 putative substrate translocation pore; other site 562970006399 Predicted transcriptional regulators [Transcription]; Region: COG1695 562970006400 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 562970006401 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 562970006402 active site 562970006403 intersubunit interface [polypeptide binding]; other site 562970006404 Zn2+ binding site [ion binding]; other site 562970006405 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 562970006406 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 562970006407 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 562970006408 NodB motif; other site 562970006409 active site 562970006410 catalytic site [active] 562970006411 metal binding site [ion binding]; metal-binding site 562970006412 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 562970006413 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 562970006414 active site 562970006415 DNA binding site [nucleotide binding] 562970006416 Int/Topo IB signature motif; other site 562970006417 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 562970006418 Putative transposase; Region: Y2_Tnp; pfam04986 562970006419 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 562970006420 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 562970006421 DNA binding residues [nucleotide binding] 562970006422 putative dimer interface [polypeptide binding]; other site 562970006423 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 562970006424 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970006425 substrate binding site [chemical binding]; other site 562970006426 oxyanion hole (OAH) forming residues; other site 562970006427 trimer interface [polypeptide binding]; other site 562970006428 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 562970006429 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970006430 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 562970006431 acyl-activating enzyme (AAE) consensus motif; other site 562970006432 putative AMP binding site [chemical binding]; other site 562970006433 putative active site [active] 562970006434 putative CoA binding site [chemical binding]; other site 562970006435 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 562970006436 SmpB-tmRNA interface; other site 562970006437 ribonuclease R; Region: RNase_R; TIGR02063 562970006438 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 562970006439 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 562970006440 RNB domain; Region: RNB; pfam00773 562970006441 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 562970006442 RNA binding site [nucleotide binding]; other site 562970006443 Esterase/lipase [General function prediction only]; Region: COG1647 562970006444 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 562970006445 enolase; Provisional; Region: eno; PRK00077 562970006446 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 562970006447 dimer interface [polypeptide binding]; other site 562970006448 metal binding site [ion binding]; metal-binding site 562970006449 substrate binding pocket [chemical binding]; other site 562970006450 phosphoglyceromutase; Provisional; Region: PRK05434 562970006451 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 562970006452 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 562970006453 triosephosphate isomerase; Provisional; Region: PRK14565 562970006454 substrate binding site [chemical binding]; other site 562970006455 dimer interface [polypeptide binding]; other site 562970006456 catalytic triad [active] 562970006457 Phosphoglycerate kinase; Region: PGK; pfam00162 562970006458 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 562970006459 substrate binding site [chemical binding]; other site 562970006460 hinge regions; other site 562970006461 ADP binding site [chemical binding]; other site 562970006462 catalytic site [active] 562970006463 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 562970006464 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 562970006465 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 562970006466 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 562970006467 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 562970006468 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 562970006469 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 562970006470 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 562970006471 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 562970006472 late competence protein ComER; Validated; Region: PRK07680 562970006473 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 562970006474 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 562970006475 UvrD-like helicase C-terminal domain; Region: UvrD_C; pfam13361 562970006476 Family description; Region: UvrD_C_2; pfam13538 562970006477 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 562970006478 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 562970006479 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 562970006480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 562970006481 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 562970006482 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 562970006483 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 562970006484 phosphate binding site [ion binding]; other site 562970006485 putative substrate binding pocket [chemical binding]; other site 562970006486 dimer interface [polypeptide binding]; other site 562970006487 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 562970006488 AAA domain; Region: AAA_33; pfam13671 562970006489 TPR repeat; Region: TPR_11; pfam13414 562970006490 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970006491 TPR motif; other site 562970006492 TPR repeat; Region: TPR_11; pfam13414 562970006493 binding surface 562970006494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970006495 TPR motif; other site 562970006496 binding surface 562970006497 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 562970006498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 562970006499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970006500 S-adenosylmethionine binding site [chemical binding]; other site 562970006501 acyl-CoA synthetase; Validated; Region: PRK08162 562970006502 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 562970006503 acyl-activating enzyme (AAE) consensus motif; other site 562970006504 putative active site [active] 562970006505 AMP binding site [chemical binding]; other site 562970006506 putative CoA binding site [chemical binding]; other site 562970006507 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 562970006508 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 562970006509 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 562970006510 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 562970006511 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 562970006512 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 562970006513 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 562970006514 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 562970006515 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 562970006516 active site 562970006517 catalytic residues [active] 562970006518 metal binding site [ion binding]; metal-binding site 562970006519 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 562970006520 CoA-transferase family III; Region: CoA_transf_3; pfam02515 562970006521 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 562970006522 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006523 putative substrate translocation pore; other site 562970006524 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 562970006525 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006526 Transcriptional regulators [Transcription]; Region: FadR; COG2186 562970006527 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970006528 DNA-binding site [nucleotide binding]; DNA binding site 562970006529 FCD domain; Region: FCD; pfam07729 562970006530 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 562970006531 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 562970006532 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 562970006533 metal binding site [ion binding]; metal-binding site 562970006534 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 562970006535 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 562970006536 substrate binding site [chemical binding]; other site 562970006537 glutamase interaction surface [polypeptide binding]; other site 562970006538 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 562970006539 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 562970006540 catalytic residues [active] 562970006541 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 562970006542 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 562970006543 putative active site [active] 562970006544 oxyanion strand; other site 562970006545 catalytic triad [active] 562970006546 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 562970006547 putative active site pocket [active] 562970006548 4-fold oligomerization interface [polypeptide binding]; other site 562970006549 metal binding residues [ion binding]; metal-binding site 562970006550 3-fold/trimer interface [polypeptide binding]; other site 562970006551 histidinol dehydrogenase; Region: hisD; TIGR00069 562970006552 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 562970006553 NAD binding site [chemical binding]; other site 562970006554 dimerization interface [polypeptide binding]; other site 562970006555 product binding site; other site 562970006556 substrate binding site [chemical binding]; other site 562970006557 zinc binding site [ion binding]; other site 562970006558 catalytic residues [active] 562970006559 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 562970006560 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 562970006561 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 562970006562 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 562970006563 dimer interface [polypeptide binding]; other site 562970006564 motif 1; other site 562970006565 active site 562970006566 motif 2; other site 562970006567 motif 3; other site 562970006568 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 562970006569 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 562970006570 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970006571 G5 domain; Region: G5; pfam07501 562970006572 Peptidase family M23; Region: Peptidase_M23; pfam01551 562970006573 Membrane protein of unknown function; Region: DUF360; pfam04020 562970006574 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 562970006575 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 562970006576 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 562970006577 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 562970006578 excinuclease ABC subunit B; Provisional; Region: PRK05298 562970006579 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970006580 ATP binding site [chemical binding]; other site 562970006581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970006582 nucleotide binding region [chemical binding]; other site 562970006583 ATP-binding site [chemical binding]; other site 562970006584 Ultra-violet resistance protein B; Region: UvrB; pfam12344 562970006585 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 562970006586 flagellar motor protein MotD; Reviewed; Region: PRK09038 562970006587 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 562970006588 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 562970006589 ligand binding site [chemical binding]; other site 562970006590 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 562970006591 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 562970006592 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 562970006593 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 562970006594 C-terminal peptidase (prc); Region: prc; TIGR00225 562970006595 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 562970006596 protein binding site [polypeptide binding]; other site 562970006597 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 562970006598 Catalytic dyad [active] 562970006599 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 562970006600 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 562970006601 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 562970006602 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 562970006603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970006604 Walker A/P-loop; other site 562970006605 ATP binding site [chemical binding]; other site 562970006606 Q-loop/lid; other site 562970006607 ABC transporter signature motif; other site 562970006608 Walker B; other site 562970006609 D-loop; other site 562970006610 H-loop/switch region; other site 562970006611 UreD urease accessory protein; Region: UreD; cl00530 562970006612 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970006613 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 562970006614 UreF; Region: UreF; pfam01730 562970006615 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 562970006616 gamma-beta subunit interface [polypeptide binding]; other site 562970006617 alpha-beta subunit interface [polypeptide binding]; other site 562970006618 urease subunit alpha; Reviewed; Region: ureC; PRK13207 562970006619 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 562970006620 subunit interactions [polypeptide binding]; other site 562970006621 active site 562970006622 flap region; other site 562970006623 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 562970006624 alpha-gamma subunit interface [polypeptide binding]; other site 562970006625 beta-gamma subunit interface [polypeptide binding]; other site 562970006626 Ion channel; Region: Ion_trans_2; pfam07885 562970006627 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970006628 S-layer homology domain; Region: SLH; pfam00395 562970006629 S-layer homology domain; Region: SLH; pfam00395 562970006630 argininosuccinate lyase; Provisional; Region: PRK00855 562970006631 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 562970006632 active sites [active] 562970006633 tetramer interface [polypeptide binding]; other site 562970006634 argininosuccinate synthase; Provisional; Region: PRK13820 562970006635 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 562970006636 ANP binding site [chemical binding]; other site 562970006637 Substrate Binding Site II [chemical binding]; other site 562970006638 Substrate Binding Site I [chemical binding]; other site 562970006639 ornithine carbamoyltransferase; Provisional; Region: PRK00779 562970006640 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 562970006641 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 562970006642 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 562970006643 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970006644 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 562970006645 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 562970006646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 562970006647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 562970006648 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 562970006649 substrate binding site [chemical binding]; other site 562970006650 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 562970006651 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 562970006652 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 562970006653 catalytic site [active] 562970006654 subunit interface [polypeptide binding]; other site 562970006655 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 562970006656 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970006657 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 562970006658 putative active site [active] 562970006659 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 562970006660 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 562970006661 CGNR zinc finger; Region: zf-CGNR; pfam11706 562970006662 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 562970006663 Integrase core domain; Region: rve; pfam00665 562970006664 Integrase core domain; Region: rve_3; pfam13683 562970006665 Uncharacterized conserved protein [Function unknown]; Region: COG1479 562970006666 Protein of unknown function DUF262; Region: DUF262; pfam03235 562970006667 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 562970006668 Uncharacterized conserved protein [Function unknown]; Region: COG3586 562970006669 Lamin Tail Domain; Region: LTD; pfam00932 562970006670 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 562970006671 generic binding surface II; other site 562970006672 generic binding surface I; other site 562970006673 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 562970006674 RPA2_OBF_family: A family of oligonucleotide binding (OB) folds with similarity to the OB fold of the single strand (ss) DNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear...; Region: RPA2_OBF_family; cd03524 562970006675 generic binding surface I; other site 562970006676 generic binding surface II; other site 562970006677 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 562970006678 S-layer homology domain; Region: SLH; pfam00395 562970006679 S-layer homology domain; Region: SLH; pfam00395 562970006680 S-layer homology domain; Region: SLH; pfam00395 562970006681 Domain of unknown function (DUF4277); Region: DUF4277; pfam14104 562970006682 Transposase [DNA replication, recombination, and repair]; Region: COG5421 562970006683 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 562970006684 Winged helix-turn helix; Region: HTH_29; pfam13551 562970006685 DDE superfamily endonuclease; Region: DDE_3; pfam13358 562970006686 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 562970006687 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 562970006688 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 562970006689 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 562970006690 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 562970006691 Catalytic domain of EDTA-resistant nuclease Nuc from Salmonella typhimurium and similar proteins; Region: PLDc_Nuc; cd09170 562970006692 PLD-like domain; Region: PLDc_2; pfam13091 562970006693 putative active site [active] 562970006694 catalytic site [active] 562970006695 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 562970006696 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970006697 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970006698 DNA binding residues [nucleotide binding] 562970006699 Putative zinc-finger; Region: zf-HC2; pfam13490 562970006700 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 562970006701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006702 putative substrate translocation pore; other site 562970006703 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 562970006704 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 562970006705 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 562970006706 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 562970006707 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 562970006708 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970006709 Walker A/P-loop; other site 562970006710 ATP binding site [chemical binding]; other site 562970006711 Q-loop/lid; other site 562970006712 ABC transporter signature motif; other site 562970006713 Walker B; other site 562970006714 D-loop; other site 562970006715 H-loop/switch region; other site 562970006716 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 562970006717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970006718 Walker A/P-loop; other site 562970006719 ATP binding site [chemical binding]; other site 562970006720 Q-loop/lid; other site 562970006721 ABC transporter signature motif; other site 562970006722 Walker B; other site 562970006723 D-loop; other site 562970006724 H-loop/switch region; other site 562970006725 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 562970006726 Helix-turn-helix; Region: HTH_3; pfam01381 562970006727 Domain of unknown function (DUF955); Region: DUF955; cl01076 562970006728 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 562970006729 Part of AAA domain; Region: AAA_19; pfam13245 562970006730 Family description; Region: UvrD_C_2; pfam13538 562970006731 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 562970006732 DNA-binding site [nucleotide binding]; DNA binding site 562970006733 RNA-binding motif; other site 562970006734 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 562970006735 CRISPR-associated protein; Region: TIGR03986 562970006736 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 562970006737 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 562970006738 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 562970006739 CRISPR/Cas system-associated RAMP superfamily protein Csx10; Region: Csx10; cl17558 562970006740 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 562970006741 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 562970006742 Part of AAA domain; Region: AAA_19; pfam13245 562970006743 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 562970006744 Vacuolar (H+)-ATPase G subunit; Region: V-ATPase_G; cl03922 562970006745 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 562970006746 AAA domain; Region: AAA_12; pfam13087 562970006747 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 562970006748 Spore germination protein; Region: Spore_permease; cl17796 562970006749 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 562970006750 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 562970006751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970006752 dimer interface [polypeptide binding]; other site 562970006753 conserved gate region; other site 562970006754 putative PBP binding loops; other site 562970006755 ABC-ATPase subunit interface; other site 562970006756 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 562970006757 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 562970006758 Walker A/P-loop; other site 562970006759 ATP binding site [chemical binding]; other site 562970006760 Q-loop/lid; other site 562970006761 ABC transporter signature motif; other site 562970006762 Walker B; other site 562970006763 D-loop; other site 562970006764 H-loop/switch region; other site 562970006765 NMT1-like family; Region: NMT1_2; pfam13379 562970006766 NMT1/THI5 like; Region: NMT1; pfam09084 562970006767 Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158 562970006768 putative homodimer interface [polypeptide binding]; other site 562970006769 putative homotetramer interface [polypeptide binding]; other site 562970006770 putative metal binding site [ion binding]; other site 562970006771 putative homodimer-homodimer interface [polypeptide binding]; other site 562970006772 putative allosteric switch controlling residues; other site 562970006773 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 562970006774 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 562970006775 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 562970006776 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 562970006777 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970006778 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 562970006779 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 562970006780 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970006781 RNA binding surface [nucleotide binding]; other site 562970006782 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 562970006783 active site 562970006784 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 562970006785 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970006786 acetylornithine aminotransferase; Provisional; Region: PRK02627 562970006787 inhibitor-cofactor binding pocket; inhibition site 562970006788 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970006789 catalytic residue [active] 562970006790 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 562970006791 feedback inhibition sensing region; other site 562970006792 homohexameric interface [polypeptide binding]; other site 562970006793 nucleotide binding site [chemical binding]; other site 562970006794 N-acetyl-L-glutamate binding site [chemical binding]; other site 562970006795 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 562970006796 heterotetramer interface [polypeptide binding]; other site 562970006797 active site pocket [active] 562970006798 cleavage site 562970006799 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 562970006800 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 562970006801 Integral membrane protein TerC family; Region: TerC; cl10468 562970006802 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 562970006803 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 562970006804 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 562970006805 EamA-like transporter family; Region: EamA; pfam00892 562970006806 EamA-like transporter family; Region: EamA; pfam00892 562970006807 Uncharacterized conserved protein [Function unknown]; Region: COG4717 562970006808 Uncharacterized conserved protein [Function unknown]; Region: COG4717 562970006809 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 562970006810 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 562970006811 active site 562970006812 metal binding site [ion binding]; metal-binding site 562970006813 DNA binding site [nucleotide binding] 562970006814 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 562970006815 Predicted membrane protein [Function unknown]; Region: COG1971 562970006816 UDP-D-galactose:(glucosyl)lipopolysaccharide-1, 6-D-galactosyltransferase; Provisional; Region: PRK09922 562970006817 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 562970006818 putative ADP-binding pocket [chemical binding]; other site 562970006819 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 562970006820 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 562970006821 active site 562970006822 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970006823 S-adenosylmethionine binding site [chemical binding]; other site 562970006824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970006826 putative substrate translocation pore; other site 562970006827 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 562970006828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970006829 dimerization interface [polypeptide binding]; other site 562970006830 putative DNA binding site [nucleotide binding]; other site 562970006831 putative Zn2+ binding site [ion binding]; other site 562970006832 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 562970006833 active site residue [active] 562970006834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006835 putative substrate translocation pore; other site 562970006836 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970006837 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970006838 putative substrate translocation pore; other site 562970006839 Helix-turn-helix domain; Region: HTH_36; pfam13730 562970006840 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 562970006841 Protein of unknown function DUF45; Region: DUF45; pfam01863 562970006842 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 562970006843 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 562970006844 putative dimer interface [polypeptide binding]; other site 562970006845 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 562970006846 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 562970006847 active site 562970006848 HIGH motif; other site 562970006849 dimer interface [polypeptide binding]; other site 562970006850 KMSKS motif; other site 562970006851 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970006852 RNA binding surface [nucleotide binding]; other site 562970006853 Transglycosylase; Region: Transgly; pfam00912 562970006854 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 562970006855 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 562970006856 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 562970006857 MutS domain III; Region: MutS_III; pfam05192 562970006858 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 562970006859 Walker A/P-loop; other site 562970006860 ATP binding site [chemical binding]; other site 562970006861 Q-loop/lid; other site 562970006862 ABC transporter signature motif; other site 562970006863 Walker B; other site 562970006864 D-loop; other site 562970006865 H-loop/switch region; other site 562970006866 Smr domain; Region: Smr; pfam01713 562970006867 Membrane protein of unknown function; Region: DUF360; pfam04020 562970006868 Cell division protein ZapA; Region: ZapA; cl01146 562970006869 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 562970006870 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 562970006871 putative tRNA-binding site [nucleotide binding]; other site 562970006872 B3/4 domain; Region: B3_4; pfam03483 562970006873 tRNA synthetase B5 domain; Region: B5; smart00874 562970006874 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 562970006875 dimer interface [polypeptide binding]; other site 562970006876 motif 1; other site 562970006877 motif 3; other site 562970006878 motif 2; other site 562970006879 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 562970006880 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 562970006881 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 562970006882 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 562970006883 dimer interface [polypeptide binding]; other site 562970006884 motif 1; other site 562970006885 active site 562970006886 motif 2; other site 562970006887 motif 3; other site 562970006888 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 562970006889 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 562970006890 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 562970006891 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 562970006892 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 562970006893 TrkA-N domain; Region: TrkA_N; pfam02254 562970006894 TrkA-C domain; Region: TrkA_C; pfam02080 562970006895 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 562970006896 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 562970006897 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 562970006898 23S rRNA binding site [nucleotide binding]; other site 562970006899 L21 binding site [polypeptide binding]; other site 562970006900 L13 binding site [polypeptide binding]; other site 562970006901 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 562970006902 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 562970006903 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 562970006904 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 562970006905 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 562970006906 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 562970006907 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 562970006908 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 562970006909 active site 562970006910 dimer interface [polypeptide binding]; other site 562970006911 motif 1; other site 562970006912 motif 2; other site 562970006913 motif 3; other site 562970006914 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 562970006915 anticodon binding site; other site 562970006916 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 562970006917 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 562970006918 ligand binding site [chemical binding]; other site 562970006919 dimer interface [polypeptide binding]; other site 562970006920 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 562970006921 CoenzymeA binding site [chemical binding]; other site 562970006922 subunit interaction site [polypeptide binding]; other site 562970006923 PHB binding site; other site 562970006924 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970006925 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970006926 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970006927 Transcriptional regulators [Transcription]; Region: FadR; COG2186 562970006928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970006929 DNA-binding site [nucleotide binding]; DNA binding site 562970006930 FCD domain; Region: FCD; pfam07729 562970006931 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 562970006932 inter-subunit interface; other site 562970006933 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 562970006934 iron-sulfur cluster [ion binding]; other site 562970006935 [2Fe-2S] cluster binding site [ion binding]; other site 562970006936 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 562970006937 beta subunit interface [polypeptide binding]; other site 562970006938 alpha subunit interface [polypeptide binding]; other site 562970006939 active site 562970006940 substrate binding site [chemical binding]; other site 562970006941 Fe binding site [ion binding]; other site 562970006942 protocatechuate 4,5-dioxygenase subunit beta; Provisional; Region: PRK13358 562970006943 active site 562970006944 metal binding site [ion binding]; metal-binding site 562970006945 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 562970006946 Subunit A of Class III extradiol dioxygenases; Region: Extradiol_Dioxygenase_3A_like; cl06673 562970006947 dimer interface [polypeptide binding]; other site 562970006948 tetramer interface [polypeptide binding]; other site 562970006949 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 562970006950 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 562970006951 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 562970006952 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 562970006953 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 562970006954 Cupin domain; Region: Cupin_2; pfam07883 562970006955 Cupin domain; Region: Cupin_2; pfam07883 562970006956 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 562970006957 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 562970006958 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 562970006959 Transcriptional regulator [Transcription]; Region: IclR; COG1414 562970006960 Bacterial transcriptional regulator; Region: IclR; pfam01614 562970006961 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970006962 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 562970006963 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 562970006964 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 562970006965 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 562970006966 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 562970006967 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970006968 catalytic loop [active] 562970006969 iron binding site [ion binding]; other site 562970006970 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 562970006971 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 562970006972 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970006973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970006974 Walker A motif; other site 562970006975 ATP binding site [chemical binding]; other site 562970006976 Walker B motif; other site 562970006977 arginine finger; other site 562970006978 short chain dehydrogenase; Provisional; Region: PRK06500 562970006979 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 562970006980 putative NAD(P) binding site [chemical binding]; other site 562970006981 putative active site [active] 562970006982 enoyl-CoA hydratase; Provisional; Region: PRK08140 562970006983 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970006984 substrate binding site [chemical binding]; other site 562970006985 oxyanion hole (OAH) forming residues; other site 562970006986 trimer interface [polypeptide binding]; other site 562970006987 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 562970006988 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970006989 substrate binding site [chemical binding]; other site 562970006990 oxyanion hole (OAH) forming residues; other site 562970006991 trimer interface [polypeptide binding]; other site 562970006992 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 562970006993 active site 2 [active] 562970006994 active site 1 [active] 562970006995 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 562970006996 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970006997 NAD(P) binding site [chemical binding]; other site 562970006998 catalytic residues [active] 562970006999 Transcriptional regulator [Transcription]; Region: IclR; COG1414 562970007000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970007001 putative Zn2+ binding site [ion binding]; other site 562970007002 putative DNA binding site [nucleotide binding]; other site 562970007003 Bacterial transcriptional regulator; Region: IclR; pfam01614 562970007004 Cupin domain; Region: Cupin_2; pfam07883 562970007005 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970007006 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970007007 active site 562970007008 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 562970007009 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 562970007010 active site 562970007011 metal binding site [ion binding]; metal-binding site 562970007012 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 562970007013 active site 562970007014 metal binding site [ion binding]; metal-binding site 562970007015 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 562970007016 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 562970007017 active site 562970007018 metal binding site [ion binding]; metal-binding site 562970007019 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 562970007020 active site 562970007021 metal binding site [ion binding]; metal-binding site 562970007022 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 562970007023 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 562970007024 catalytic loop [active] 562970007025 iron binding site [ion binding]; other site 562970007026 putative indolepyruvate oxidoreductase subunit B; Reviewed; Region: PRK08312 562970007027 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 562970007028 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 562970007029 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 562970007030 dimer interface [polypeptide binding]; other site 562970007031 PYR/PP interface [polypeptide binding]; other site 562970007032 TPP binding site [chemical binding]; other site 562970007033 substrate binding site [chemical binding]; other site 562970007034 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 562970007035 TPP-binding site; other site 562970007036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 562970007037 NlpC/P60 family; Region: NLPC_P60; pfam00877 562970007038 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970007039 putative active site [active] 562970007040 S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124 562970007041 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 562970007042 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970007043 substrate binding site [chemical binding]; other site 562970007044 oxyanion hole (OAH) forming residues; other site 562970007045 trimer interface [polypeptide binding]; other site 562970007046 Thymidylate synthase complementing protein; Region: Thy1; cl03630 562970007047 Thymidylate synthase complementing protein; Region: Thy1; cl03630 562970007048 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 562970007049 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 562970007050 DNA binding residues [nucleotide binding] 562970007051 Peptidase family M48; Region: Peptidase_M48; cl12018 562970007052 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 562970007053 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 562970007054 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 562970007055 Peptidase family M23; Region: Peptidase_M23; pfam01551 562970007056 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 562970007057 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 562970007058 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 562970007059 FOG: CBS domain [General function prediction only]; Region: COG0517 562970007060 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 562970007061 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 562970007062 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 562970007063 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 562970007064 dimer interface [polypeptide binding]; other site 562970007065 Citrate synthase; Region: Citrate_synt; pfam00285 562970007066 active site 562970007067 citrylCoA binding site [chemical binding]; other site 562970007068 oxalacetate/citrate binding site [chemical binding]; other site 562970007069 coenzyme A binding site [chemical binding]; other site 562970007070 catalytic triad [active] 562970007071 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 562970007072 MoaE homodimer interface [polypeptide binding]; other site 562970007073 MoaD interaction [polypeptide binding]; other site 562970007074 active site residues [active] 562970007075 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 562970007076 MoaE interaction surface [polypeptide binding]; other site 562970007077 MoeB interaction surface [polypeptide binding]; other site 562970007078 thiocarboxylated glycine; other site 562970007079 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 562970007080 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 562970007081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970007082 active site 562970007083 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 562970007084 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 562970007085 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 562970007086 NAD(P) binding site [chemical binding]; other site 562970007087 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970007088 transcriptional repressor CodY; Validated; Region: PRK04158 562970007089 CodY GAF-like domain; Region: CodY; pfam06018 562970007090 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 562970007091 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 562970007092 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 562970007093 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 562970007094 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 562970007095 substrate binding site [chemical binding]; other site 562970007096 ligand binding site [chemical binding]; other site 562970007097 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 562970007098 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 562970007099 substrate binding site [chemical binding]; other site 562970007100 Coat F domain; Region: Coat_F; pfam07875 562970007101 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970007102 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970007103 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 562970007104 Peptidase family M50; Region: Peptidase_M50; pfam02163 562970007105 active site 562970007106 putative substrate binding region [chemical binding]; other site 562970007107 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 562970007108 Flagellar protein YcgR; Region: YcgR_2; pfam12945 562970007109 PilZ domain; Region: PilZ; pfam07238 562970007110 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 562970007111 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 562970007112 E3 interaction surface; other site 562970007113 lipoyl attachment site [posttranslational modification]; other site 562970007114 e3 binding domain; Region: E3_binding; pfam02817 562970007115 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 562970007116 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 562970007117 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 562970007118 alpha subunit interface [polypeptide binding]; other site 562970007119 TPP binding site [chemical binding]; other site 562970007120 heterodimer interface [polypeptide binding]; other site 562970007121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970007122 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 562970007123 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 562970007124 tetramer interface [polypeptide binding]; other site 562970007125 TPP-binding site [chemical binding]; other site 562970007126 heterodimer interface [polypeptide binding]; other site 562970007127 phosphorylation loop region [posttranslational modification] 562970007128 GAF domain; Region: GAF; pfam01590 562970007129 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 562970007130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970007131 Walker B motif; other site 562970007132 arginine finger; other site 562970007133 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 562970007134 DNA-binding interface [nucleotide binding]; DNA binding site 562970007135 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 562970007136 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 562970007137 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 562970007138 catalytic triad [active] 562970007139 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 562970007140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970007141 Walker A motif; other site 562970007142 ATP binding site [chemical binding]; other site 562970007143 Walker B motif; other site 562970007144 arginine finger; other site 562970007145 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 562970007146 IHF dimer interface [polypeptide binding]; other site 562970007147 IHF - DNA interface [nucleotide binding]; other site 562970007148 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 562970007149 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 562970007150 acyl-activating enzyme (AAE) consensus motif; other site 562970007151 putative AMP binding site [chemical binding]; other site 562970007152 putative active site [active] 562970007153 putative CoA binding site [chemical binding]; other site 562970007154 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 562970007155 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 562970007156 RNA binding surface [nucleotide binding]; other site 562970007157 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 562970007158 active site 562970007159 uracil binding [chemical binding]; other site 562970007160 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 562970007161 dimer interface [polypeptide binding]; other site 562970007162 Citrate synthase; Region: Citrate_synt; pfam00285 562970007163 active site 562970007164 citrylCoA binding site [chemical binding]; other site 562970007165 oxalacetate/citrate binding site [chemical binding]; other site 562970007166 coenzyme A binding site [chemical binding]; other site 562970007167 catalytic triad [active] 562970007168 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 562970007169 Predicted membrane protein [Function unknown]; Region: COG3766 562970007170 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 562970007171 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 562970007172 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 562970007173 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 562970007174 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 562970007175 4Fe-4S binding domain; Region: Fer4; pfam00037 562970007176 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 562970007177 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 562970007178 Cysteine-rich domain; Region: CCG; pfam02754 562970007179 Cysteine-rich domain; Region: CCG; pfam02754 562970007180 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 562970007181 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 562970007182 dimer interface [polypeptide binding]; other site 562970007183 putative PBP binding regions; other site 562970007184 ABC-ATPase subunit interface; other site 562970007185 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 562970007186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970007187 Walker A/P-loop; other site 562970007188 ATP binding site [chemical binding]; other site 562970007189 Q-loop/lid; other site 562970007190 ABC transporter signature motif; other site 562970007191 Walker B; other site 562970007192 D-loop; other site 562970007193 H-loop/switch region; other site 562970007194 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 562970007195 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 562970007196 intersubunit interface [polypeptide binding]; other site 562970007197 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 562970007198 metal binding site 2 [ion binding]; metal-binding site 562970007199 putative DNA binding helix; other site 562970007200 metal binding site 1 [ion binding]; metal-binding site 562970007201 dimer interface [polypeptide binding]; other site 562970007202 structural Zn2+ binding site [ion binding]; other site 562970007203 cell division protein GpsB; Provisional; Region: PRK14127 562970007204 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 562970007205 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 562970007206 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 562970007207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007208 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970007209 S-adenosylmethionine binding site [chemical binding]; other site 562970007210 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 562970007211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007212 putative substrate translocation pore; other site 562970007213 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 562970007214 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 562970007215 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 562970007216 DNA binding residues [nucleotide binding] 562970007217 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 562970007218 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970007219 dimer interface [polypeptide binding]; other site 562970007220 putative CheW interface [polypeptide binding]; other site 562970007221 Cache domain; Region: Cache_1; pfam02743 562970007222 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 562970007223 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 562970007224 nucleotide binding site [chemical binding]; other site 562970007225 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 562970007226 active site 562970007227 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 562970007228 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 562970007229 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 562970007230 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 562970007231 N-acetyl-D-glucosamine binding site [chemical binding]; other site 562970007232 catalytic residue [active] 562970007233 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 562970007234 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 562970007235 CoA-binding site [chemical binding]; other site 562970007236 ATP-binding [chemical binding]; other site 562970007237 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 562970007238 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 562970007239 DNA binding site [nucleotide binding] 562970007240 catalytic residue [active] 562970007241 H2TH interface [polypeptide binding]; other site 562970007242 putative catalytic residues [active] 562970007243 turnover-facilitating residue; other site 562970007244 intercalation triad [nucleotide binding]; other site 562970007245 8OG recognition residue [nucleotide binding]; other site 562970007246 putative reading head residues; other site 562970007247 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 562970007248 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 562970007249 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 562970007250 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 562970007251 iron-sulfur cluster [ion binding]; other site 562970007252 [2Fe-2S] cluster binding site [ion binding]; other site 562970007253 DNA polymerase I; Provisional; Region: PRK05755 562970007254 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 562970007255 active site 562970007256 metal binding site 1 [ion binding]; metal-binding site 562970007257 putative 5' ssDNA interaction site; other site 562970007258 metal binding site 3; metal-binding site 562970007259 metal binding site 2 [ion binding]; metal-binding site 562970007260 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 562970007261 putative DNA binding site [nucleotide binding]; other site 562970007262 putative metal binding site [ion binding]; other site 562970007263 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 562970007264 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 562970007265 active site 562970007266 DNA binding site [nucleotide binding] 562970007267 catalytic site [active] 562970007268 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 562970007269 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 562970007270 peptide binding site [polypeptide binding]; other site 562970007271 malate dehydrogenase; Reviewed; Region: PRK06223 562970007272 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 562970007273 NAD(P) binding site [chemical binding]; other site 562970007274 dimer interface [polypeptide binding]; other site 562970007275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 562970007276 substrate binding site [chemical binding]; other site 562970007277 isocitrate dehydrogenase; Validated; Region: PRK07362 562970007278 isocitrate dehydrogenase; Reviewed; Region: PRK07006 562970007279 pyruvate kinase; Provisional; Region: PRK06354 562970007280 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 562970007281 domain interfaces; other site 562970007282 active site 562970007283 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl17700 562970007284 6-phosphofructokinase; Provisional; Region: PRK03202 562970007285 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 562970007286 active site 562970007287 ADP/pyrophosphate binding site [chemical binding]; other site 562970007288 dimerization interface [polypeptide binding]; other site 562970007289 allosteric effector site; other site 562970007290 fructose-1,6-bisphosphate binding site; other site 562970007291 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 562970007292 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 562970007293 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 562970007294 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 562970007295 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 562970007296 Malic enzyme, N-terminal domain; Region: malic; pfam00390 562970007297 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 562970007298 putative NAD(P) binding site [chemical binding]; other site 562970007299 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 562970007300 tetramer interfaces [polypeptide binding]; other site 562970007301 binuclear metal-binding site [ion binding]; other site 562970007302 DNA-directed DNA polymerase III (polc); Region: polc; TIGR00594 562970007303 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 562970007304 active site 562970007305 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 562970007306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 562970007307 DNA-binding site [nucleotide binding]; DNA binding site 562970007308 DRTGG domain; Region: DRTGG; pfam07085 562970007309 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 562970007310 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 562970007311 active site 2 [active] 562970007312 active site 1 [active] 562970007313 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 562970007314 active site 562970007315 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 562970007316 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 562970007317 metal-dependent hydrolase; Provisional; Region: PRK00685 562970007318 Glyco_18 domain; Region: Glyco_18; smart00636 562970007319 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 562970007320 active site 562970007321 S-layer homology domain; Region: SLH; pfam00395 562970007322 S-layer homology domain; Region: SLH; pfam00395 562970007323 S-layer homology domain; Region: SLH; pfam00395 562970007324 Protein of unknown function (DUF445); Region: DUF445; pfam04286 562970007325 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 562970007326 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 562970007327 PYR/PP interface [polypeptide binding]; other site 562970007328 dimer interface [polypeptide binding]; other site 562970007329 TPP binding site [chemical binding]; other site 562970007330 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 562970007331 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 562970007332 TPP-binding site [chemical binding]; other site 562970007333 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 562970007334 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 562970007335 active site 562970007336 substrate-binding site [chemical binding]; other site 562970007337 metal-binding site [ion binding] 562970007338 ATP binding site [chemical binding]; other site 562970007339 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 562970007340 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 562970007341 Walker A/P-loop; other site 562970007342 ATP binding site [chemical binding]; other site 562970007343 Q-loop/lid; other site 562970007344 ABC transporter signature motif; other site 562970007345 Walker B; other site 562970007346 D-loop; other site 562970007347 H-loop/switch region; other site 562970007348 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 562970007349 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 562970007350 ABC-ATPase subunit interface; other site 562970007351 dimer interface [polypeptide binding]; other site 562970007352 putative PBP binding regions; other site 562970007353 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 562970007354 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 562970007355 putative binding site residues; other site 562970007356 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970007357 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970007358 active site 562970007359 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 562970007360 AAA domain; Region: AAA_30; pfam13604 562970007361 Family description; Region: UvrD_C_2; pfam13538 562970007362 oligoendopeptidase F; Region: pepF; TIGR00181 562970007363 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 562970007364 active site 562970007365 Zn binding site [ion binding]; other site 562970007366 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 562970007367 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 562970007368 active site residue [active] 562970007369 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 562970007370 active site residue [active] 562970007371 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 562970007372 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 562970007373 malonyl-CoA binding site [chemical binding]; other site 562970007374 dimer interface [polypeptide binding]; other site 562970007375 active site 562970007376 product binding site; other site 562970007377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 562970007378 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 562970007379 NlpC/P60 family; Region: NLPC_P60; cl17555 562970007380 Bacterial SH3 domain homologues; Region: SH3b; smart00287 562970007381 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 562970007382 Uncharacterized conserved protein [Function unknown]; Region: COG1683 562970007383 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 562970007384 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 562970007385 DNA binding site [nucleotide binding] 562970007386 active site 562970007387 Acetone carboxylase, gamma subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcxC; COG4647 562970007388 Acetone carboxylase gamma subunit; Region: Acetone_carb_G; pfam08882 562970007389 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 562970007390 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 562970007391 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 562970007392 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 562970007393 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 562970007394 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 562970007395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970007396 Walker A motif; other site 562970007397 ATP binding site [chemical binding]; other site 562970007398 Walker B motif; other site 562970007399 arginine finger; other site 562970007400 manganese transport protein MntH; Reviewed; Region: PRK00701 562970007401 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 562970007402 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 562970007403 4Fe-4S binding domain; Region: Fer4; pfam00037 562970007404 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 562970007405 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 562970007406 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 562970007407 molybdopterin cofactor binding site; other site 562970007408 This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780 562970007409 putative molybdopterin cofactor binding site; other site 562970007410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 562970007411 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 562970007412 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 562970007413 active site 562970007414 metal binding site [ion binding]; metal-binding site 562970007415 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 562970007416 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970007417 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970007418 DNA binding residues [nucleotide binding] 562970007419 dimerization interface [polypeptide binding]; other site 562970007420 Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856 562970007421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007422 FeS/SAM binding site; other site 562970007423 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 562970007424 Biotin synthase-related enzyme [General function prediction only]; Region: COG2516 562970007425 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007426 FeS/SAM binding site; other site 562970007427 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 562970007428 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 562970007429 lipoyl attachment site [posttranslational modification]; other site 562970007430 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 562970007431 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 562970007432 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 562970007433 Predicted peroxiredoxins [General function prediction only]; Region: COG2044 562970007434 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 562970007435 CPxP motif; other site 562970007436 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 562970007437 glycine cleavage system protein H; Provisional; Region: PRK13380 562970007438 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 562970007439 lipoyl attachment site [posttranslational modification]; other site 562970007440 glycine cleavage system protein H; Provisional; Region: PRK13380 562970007441 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 562970007442 lipoyl attachment site [posttranslational modification]; other site 562970007443 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 562970007444 4Fe-4S binding domain; Region: Fer4; cl02805 562970007445 4Fe-4S binding domain; Region: Fer4_3; pfam12798 562970007446 Cysteine-rich domain; Region: CCG; pfam02754 562970007447 Cysteine-rich domain; Region: CCG; pfam02754 562970007448 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 562970007449 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 562970007450 Ligand binding site [chemical binding]; other site 562970007451 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 562970007452 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 562970007453 Ligand Binding Site [chemical binding]; other site 562970007454 Electron transfer flavoprotein domain; Region: ETF; pfam01012 562970007455 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 562970007456 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 562970007457 Cysteine-rich domain; Region: CCG; pfam02754 562970007458 Cysteine-rich domain; Region: CCG; pfam02754 562970007459 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970007460 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 562970007461 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 562970007462 Cysteine-rich domain; Region: CCG; pfam02754 562970007463 4Fe-4S dicluster domain; Region: Fer4_17; pfam13534 562970007464 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 562970007465 SpoVR like protein; Region: SpoVR; pfam04293 562970007466 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 562970007467 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 562970007468 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 562970007469 Colicin V production protein; Region: Colicin_V; pfam02674 562970007470 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 562970007471 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 562970007472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 562970007473 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 562970007474 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 562970007475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970007476 motif II; other site 562970007477 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 562970007478 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 562970007479 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 562970007480 PAS domain; Region: PAS; smart00091 562970007481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970007482 dimer interface [polypeptide binding]; other site 562970007483 phosphorylation site [posttranslational modification] 562970007484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970007485 ATP binding site [chemical binding]; other site 562970007486 Mg2+ binding site [ion binding]; other site 562970007487 G-X-G motif; other site 562970007488 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970007489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970007490 active site 562970007491 phosphorylation site [posttranslational modification] 562970007492 intermolecular recognition site; other site 562970007493 dimerization interface [polypeptide binding]; other site 562970007494 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970007495 DNA binding site [nucleotide binding] 562970007496 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 562970007497 Acylphosphatase; Region: Acylphosphatase; cl00551 562970007498 HypF finger; Region: zf-HYPF; pfam07503 562970007499 HypF finger; Region: zf-HYPF; pfam07503 562970007500 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 562970007501 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 562970007502 catalytic residues [active] 562970007503 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 562970007504 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 562970007505 dimer interface [polypeptide binding]; other site 562970007506 active site 562970007507 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 562970007508 dimerization interface [polypeptide binding]; other site 562970007509 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 562970007510 ATP binding site [chemical binding]; other site 562970007511 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 562970007512 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 562970007513 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 562970007514 HupF/HypC family; Region: HupF_HypC; pfam01455 562970007515 HupF/HypC family; Region: HupF_HypC; pfam01455 562970007516 NifU-like domain; Region: NifU; cl00484 562970007517 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 562970007518 iron-sulfur cluster [ion binding]; other site 562970007519 [2Fe-2S] cluster binding site [ion binding]; other site 562970007520 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970007521 binding surface 562970007522 TPR motif; other site 562970007523 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 562970007524 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 562970007525 nickel binding site [ion binding]; other site 562970007526 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 562970007527 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 562970007528 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 562970007529 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970007530 Protein of unknown function (DUF1641); Region: DUF1641; pfam07849 562970007531 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 562970007532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970007533 dimer interface [polypeptide binding]; other site 562970007534 conserved gate region; other site 562970007535 putative PBP binding loops; other site 562970007536 ABC-ATPase subunit interface; other site 562970007537 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 562970007538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970007539 dimer interface [polypeptide binding]; other site 562970007540 conserved gate region; other site 562970007541 putative PBP binding loops; other site 562970007542 ABC-ATPase subunit interface; other site 562970007543 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 562970007544 PhoU domain; Region: PhoU; pfam01895 562970007545 PhoU domain; Region: PhoU; pfam01895 562970007546 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 562970007547 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 562970007548 Walker A/P-loop; other site 562970007549 ATP binding site [chemical binding]; other site 562970007550 Q-loop/lid; other site 562970007551 ABC transporter signature motif; other site 562970007552 Walker B; other site 562970007553 D-loop; other site 562970007554 H-loop/switch region; other site 562970007555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970007556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970007557 active site 562970007558 phosphorylation site [posttranslational modification] 562970007559 intermolecular recognition site; other site 562970007560 dimerization interface [polypeptide binding]; other site 562970007561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970007562 DNA binding site [nucleotide binding] 562970007563 HAMP domain; Region: HAMP; pfam00672 562970007564 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970007565 dimer interface [polypeptide binding]; other site 562970007566 putative CheW interface [polypeptide binding]; other site 562970007567 PBP superfamily domain; Region: PBP_like_2; cl17296 562970007568 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970007569 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970007570 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 562970007571 Mechanosensitive ion channel; Region: MS_channel; pfam00924 562970007572 aconitate hydratase; Validated; Region: PRK09277 562970007573 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 562970007574 substrate binding site [chemical binding]; other site 562970007575 ligand binding site [chemical binding]; other site 562970007576 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 562970007577 substrate binding site [chemical binding]; other site 562970007578 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 562970007579 putative active site [active] 562970007580 putative CoA binding site [chemical binding]; other site 562970007581 nudix motif; other site 562970007582 metal binding site [ion binding]; metal-binding site 562970007583 Putative amidase domain; Region: Amidase_6; pfam12671 562970007584 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 562970007585 Transcriptional regulator [Transcription]; Region: IclR; COG1414 562970007586 Bacterial transcriptional regulator; Region: IclR; pfam01614 562970007587 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 562970007588 tartrate dehydrogenase; Provisional; Region: PRK08194 562970007589 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 562970007590 ATP binding site [chemical binding]; other site 562970007591 spore coat protein, CotS family; Region: spore_CotS; TIGR02906 562970007592 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 562970007593 substrate binding site [chemical binding]; other site 562970007594 epoxyqueuosine reductase; Region: TIGR00276 562970007595 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 562970007596 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cd00020 562970007597 protein binding surface [polypeptide binding]; other site 562970007598 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 562970007599 active site 562970007600 RNA/DNA hybrid binding site [nucleotide binding]; other site 562970007601 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 562970007602 hypothetical protein; Provisional; Region: PRK02935 562970007603 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 562970007604 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 562970007605 minor groove reading motif; other site 562970007606 helix-hairpin-helix signature motif; other site 562970007607 substrate binding pocket [chemical binding]; other site 562970007608 active site 562970007609 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 562970007610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007611 putative substrate translocation pore; other site 562970007612 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 562970007613 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 562970007614 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970007615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007616 putative substrate translocation pore; other site 562970007617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007618 putative substrate translocation pore; other site 562970007619 ABC-2 type transporter; Region: ABC2_membrane; cl17235 562970007620 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 562970007621 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 562970007622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970007623 Walker A/P-loop; other site 562970007624 ATP binding site [chemical binding]; other site 562970007625 Q-loop/lid; other site 562970007626 ABC transporter signature motif; other site 562970007627 Walker B; other site 562970007628 D-loop; other site 562970007629 H-loop/switch region; other site 562970007630 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970007631 dimerization interface [polypeptide binding]; other site 562970007632 putative DNA binding site [nucleotide binding]; other site 562970007633 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 562970007634 putative Zn2+ binding site [ion binding]; other site 562970007635 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 562970007636 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 562970007637 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 562970007638 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 562970007639 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 562970007640 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 562970007641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970007642 NAD(P) binding site [chemical binding]; other site 562970007643 active site 562970007644 Protein of unknown function, DUF488; Region: DUF488; cl01246 562970007645 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 562970007646 FMN binding site [chemical binding]; other site 562970007647 dimer interface [polypeptide binding]; other site 562970007648 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 562970007649 Hemerythrin-like domain; Region: Hr-like; cd12108 562970007650 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 562970007651 putative active site [active] 562970007652 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 562970007653 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970007654 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 562970007655 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007656 FeS/SAM binding site; other site 562970007657 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 562970007658 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 562970007659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007660 FeS/SAM binding site; other site 562970007661 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 562970007662 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 562970007663 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 562970007664 ligand binding site [chemical binding]; other site 562970007665 flexible hinge region; other site 562970007666 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 562970007667 non-specific DNA interactions [nucleotide binding]; other site 562970007668 DNA binding site [nucleotide binding] 562970007669 sequence specific DNA binding site [nucleotide binding]; other site 562970007670 putative cAMP binding site [chemical binding]; other site 562970007671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970007672 dimer interface [polypeptide binding]; other site 562970007673 conserved gate region; other site 562970007674 putative PBP binding loops; other site 562970007675 ABC-ATPase subunit interface; other site 562970007676 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 562970007677 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 562970007678 Walker A/P-loop; other site 562970007679 ATP binding site [chemical binding]; other site 562970007680 Q-loop/lid; other site 562970007681 ABC transporter signature motif; other site 562970007682 Walker B; other site 562970007683 D-loop; other site 562970007684 H-loop/switch region; other site 562970007685 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 562970007686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970007687 dimer interface [polypeptide binding]; other site 562970007688 conserved gate region; other site 562970007689 putative PBP binding loops; other site 562970007690 ABC-ATPase subunit interface; other site 562970007691 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 562970007692 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 562970007693 substrate binding pocket [chemical binding]; other site 562970007694 membrane-bound complex binding site; other site 562970007695 hinge residues; other site 562970007696 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 562970007697 Mechanosensitive ion channel; Region: MS_channel; pfam00924 562970007698 FeoA domain; Region: FeoA; pfam04023 562970007699 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 562970007700 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 562970007701 G1 box; other site 562970007702 GTP/Mg2+ binding site [chemical binding]; other site 562970007703 Switch I region; other site 562970007704 G2 box; other site 562970007705 G3 box; other site 562970007706 Switch II region; other site 562970007707 G4 box; other site 562970007708 G5 box; other site 562970007709 Nucleoside recognition; Region: Gate; pfam07670 562970007710 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 562970007711 Nucleoside recognition; Region: Gate; pfam07670 562970007712 Virus attachment protein p12 family; Region: P12; pfam12669 562970007713 Cupin domain; Region: Cupin_2; cl17218 562970007714 Part of AAA domain; Region: AAA_19; pfam13245 562970007715 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 562970007716 AAA domain; Region: AAA_12; pfam13087 562970007717 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 562970007718 putative metal binding site; other site 562970007719 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 562970007720 binding surface 562970007721 TPR motif; other site 562970007722 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 562970007723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970007724 ATP binding site [chemical binding]; other site 562970007725 G-X-G motif; other site 562970007726 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 562970007727 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 562970007728 Cu(I) binding site [ion binding]; other site 562970007729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970007730 Zn2+ binding site [ion binding]; other site 562970007731 Mg2+ binding site [ion binding]; other site 562970007732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 562970007733 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 562970007734 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 562970007735 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 562970007736 NAD binding site [chemical binding]; other site 562970007737 ligand binding site [chemical binding]; other site 562970007738 catalytic site [active] 562970007739 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 562970007740 Low molecular weight phosphatase family; Region: LMWPc; cd00115 562970007741 active site 562970007742 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 562970007743 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 562970007744 Zn binding site [ion binding]; other site 562970007745 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 562970007746 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 562970007747 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 562970007748 metal-binding site [ion binding] 562970007749 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 562970007750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 562970007751 motif II; other site 562970007752 biotin synthase; Validated; Region: PRK06256 562970007753 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007754 FeS/SAM binding site; other site 562970007755 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 562970007756 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 562970007757 AAA domain; Region: AAA_26; pfam13500 562970007758 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 562970007759 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 562970007760 substrate-cofactor binding pocket; other site 562970007761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970007762 catalytic residue [active] 562970007763 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK06916 562970007764 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970007765 inhibitor-cofactor binding pocket; inhibition site 562970007766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970007767 catalytic residue [active] 562970007768 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 562970007769 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 562970007770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007771 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970007772 putative substrate translocation pore; other site 562970007773 Predicted membrane protein [Function unknown]; Region: COG1971 562970007774 Pirin-related protein [General function prediction only]; Region: COG1741 562970007775 Pirin; Region: Pirin; pfam02678 562970007776 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 562970007777 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 562970007778 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 562970007779 putative NAD(P) binding site [chemical binding]; other site 562970007780 active site 562970007781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 562970007782 Protein of unknown function (DUF402); Region: DUF402; cl00979 562970007783 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 562970007784 Domain of unknown function DUF20; Region: UPF0118; pfam01594 562970007785 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970007786 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 562970007787 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 562970007788 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 562970007789 minor groove reading motif; other site 562970007790 helix-hairpin-helix signature motif; other site 562970007791 substrate binding pocket [chemical binding]; other site 562970007792 active site 562970007793 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 562970007794 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 562970007795 DNA binding and oxoG recognition site [nucleotide binding] 562970007796 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 562970007797 EamA-like transporter family; Region: EamA; pfam00892 562970007798 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 562970007799 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 562970007800 dimer interface [polypeptide binding]; other site 562970007801 substrate binding site [chemical binding]; other site 562970007802 ATP binding site [chemical binding]; other site 562970007803 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 562970007804 Fumarase C-terminus; Region: Fumerase_C; pfam05683 562970007805 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 562970007806 Transcriptional regulator [Transcription]; Region: IclR; COG1414 562970007807 Bacterial transcriptional regulator; Region: IclR; pfam01614 562970007808 L-lactate permease; Region: Lactate_perm; cl00701 562970007809 L-lactate permease [Energy production and conversion]; Region: LldP; COG1620 562970007810 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 562970007811 FAD binding domain; Region: FAD_binding_4; pfam01565 562970007812 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 562970007813 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 562970007814 Cysteine-rich domain; Region: CCG; pfam02754 562970007815 Cysteine-rich domain; Region: CCG; pfam02754 562970007816 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 562970007817 FAD binding domain; Region: FAD_binding_4; pfam01565 562970007818 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 562970007819 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 562970007820 Imelysin; Region: Peptidase_M75; pfam09375 562970007821 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 562970007822 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007823 FeS/SAM binding site; other site 562970007824 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 562970007825 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 562970007826 Ligand binding site; other site 562970007827 metal-binding site 562970007828 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 562970007829 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 562970007830 MoxR-like ATPases [General function prediction only]; Region: COG0714 562970007831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 562970007832 Walker A motif; other site 562970007833 ATP binding site [chemical binding]; other site 562970007834 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 562970007835 FAD binding domain; Region: FAD_binding_4; pfam01565 562970007836 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 562970007837 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 562970007838 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 562970007839 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 562970007840 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 562970007841 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 562970007842 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 562970007843 putative hydrophobic ligand binding site [chemical binding]; other site 562970007844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970007845 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970007846 putative substrate translocation pore; other site 562970007847 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 562970007848 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 562970007849 DHH family; Region: DHH; pfam01368 562970007850 DHHA1 domain; Region: DHHA1; pfam02272 562970007851 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 562970007852 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 562970007853 AAA domain; Region: AAA_23; pfam13476 562970007854 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 562970007855 acyl-CoA synthetase; Validated; Region: PRK08316 562970007856 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970007857 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 562970007858 acyl-activating enzyme (AAE) consensus motif; other site 562970007859 putative AMP binding site [chemical binding]; other site 562970007860 putative active site [active] 562970007861 putative CoA binding site [chemical binding]; other site 562970007862 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 562970007863 apolar tunnel; other site 562970007864 heme binding site [chemical binding]; other site 562970007865 dimerization interface [polypeptide binding]; other site 562970007866 Predicted permeases [General function prediction only]; Region: COG0679 562970007867 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 562970007868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 562970007869 motif II; other site 562970007870 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 562970007871 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 562970007872 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 562970007873 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 562970007874 TPP-binding site [chemical binding]; other site 562970007875 dimer interface [polypeptide binding]; other site 562970007876 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 562970007877 PYR/PP interface [polypeptide binding]; other site 562970007878 dimer interface [polypeptide binding]; other site 562970007879 TPP binding site [chemical binding]; other site 562970007880 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 562970007881 CcmE; Region: CcmE; cl00994 562970007882 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 562970007883 Cytochrome C biogenesis protein; Region: CcmH; cl01179 562970007884 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 562970007885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970007886 Walker A/P-loop; other site 562970007887 ATP binding site [chemical binding]; other site 562970007888 Q-loop/lid; other site 562970007889 ABC transporter signature motif; other site 562970007890 Walker B; other site 562970007891 D-loop; other site 562970007892 H-loop/switch region; other site 562970007893 CcmB protein; Region: CcmB; cl17444 562970007894 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 562970007895 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 562970007896 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 562970007897 catalytic residues [active] 562970007898 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 562970007899 ApbE family; Region: ApbE; pfam02424 562970007900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 562970007901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970007902 active site 562970007903 phosphorylation site [posttranslational modification] 562970007904 intermolecular recognition site; other site 562970007905 dimerization interface [polypeptide binding]; other site 562970007906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 562970007907 DNA binding site [nucleotide binding] 562970007908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 562970007909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 562970007910 dimer interface [polypeptide binding]; other site 562970007911 phosphorylation site [posttranslational modification] 562970007912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 562970007913 ATP binding site [chemical binding]; other site 562970007914 Mg2+ binding site [ion binding]; other site 562970007915 G-X-G motif; other site 562970007916 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 562970007917 putative deacylase active site [active] 562970007918 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 562970007919 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 562970007920 endonuclease III; Region: ENDO3c; smart00478 562970007921 minor groove reading motif; other site 562970007922 helix-hairpin-helix signature motif; other site 562970007923 substrate binding pocket [chemical binding]; other site 562970007924 active site 562970007925 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 562970007926 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 562970007927 metal-binding site [ion binding] 562970007928 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 562970007929 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 562970007930 metal-binding site [ion binding] 562970007931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 562970007932 Soluble P-type ATPase [General function prediction only]; Region: COG4087 562970007933 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 562970007934 Radical SAM superfamily; Region: Radical_SAM; pfam04055 562970007935 FeS/SAM binding site; other site 562970007936 Predicted transcriptional regulators [Transcription]; Region: COG1725 562970007937 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970007938 DNA-binding site [nucleotide binding]; DNA binding site 562970007939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970007940 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 562970007941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970007942 Walker A/P-loop; other site 562970007943 ATP binding site [chemical binding]; other site 562970007944 Q-loop/lid; other site 562970007945 ABC transporter signature motif; other site 562970007946 Walker B; other site 562970007947 D-loop; other site 562970007948 H-loop/switch region; other site 562970007949 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 562970007950 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 562970007951 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 562970007952 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 562970007953 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 562970007954 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 562970007955 CRISPR-associated protein Csx17, subtype Dpsyc; Region: cas_csx17; TIGR04113 562970007956 CRISPR/Cas system-associated protein Csx17; Region: Csx17_I-U; cd09767 562970007957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 562970007958 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 562970007959 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 562970007960 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 562970007961 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 562970007962 WHG domain; Region: WHG; pfam13305 562970007963 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 562970007964 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 562970007965 Predicted transcriptional regulators [Transcription]; Region: COG1725 562970007966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970007967 DNA-binding site [nucleotide binding]; DNA binding site 562970007968 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970007969 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 562970007970 Walker A/P-loop; other site 562970007971 ATP binding site [chemical binding]; other site 562970007972 Q-loop/lid; other site 562970007973 ABC transporter signature motif; other site 562970007974 Walker B; other site 562970007975 D-loop; other site 562970007976 H-loop/switch region; other site 562970007977 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 562970007978 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 562970007979 HicB family; Region: HicB; pfam05534 562970007980 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 562970007981 Amidohydrolase; Region: Amidohydro_2; pfam04909 562970007982 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 562970007983 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079 562970007984 DinB family; Region: DinB; cl17821 562970007985 DinB superfamily; Region: DinB_2; pfam12867 562970007986 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970007987 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 562970007988 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 562970007989 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970007990 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970007991 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 562970007992 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 562970007993 classical (c) SDRs; Region: SDR_c; cd05233 562970007994 NAD(P) binding site [chemical binding]; other site 562970007995 active site 562970007996 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 562970007997 substrate binding pocket [chemical binding]; other site 562970007998 NMT1/THI5 like; Region: NMT1; pfam09084 562970007999 membrane-bound complex binding site; other site 562970008000 hinge residues; other site 562970008001 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 562970008002 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 562970008003 putative NAD(P) binding site [chemical binding]; other site 562970008004 dimer interface [polypeptide binding]; other site 562970008005 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 562970008006 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 562970008007 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 562970008008 methionine synthase; Provisional; Region: PRK01207 562970008009 substrate binding site [chemical binding]; other site 562970008010 THF binding site; other site 562970008011 zinc-binding site [ion binding]; other site 562970008012 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 562970008013 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 562970008014 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 562970008015 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 562970008016 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 562970008017 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 562970008018 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 562970008019 CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718 562970008020 NAD-dependent deacetylase; Provisional; Region: PRK00481 562970008021 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 562970008022 YCII-related domain; Region: YCII; pfam03795 562970008023 CRISPR-associated (Cas) DxTHG family; Region: Cas_DxTHG; pfam09455 562970008024 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 562970008025 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl17439 562970008026 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970008027 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970008028 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970008029 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 562970008030 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 562970008031 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 562970008032 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 562970008033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 562970008034 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 562970008035 Family of unknown function (DUF694); Region: DUF694; pfam05107 562970008036 CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881 562970008037 NAD-dependent deacetylase; Provisional; Region: PRK00481 562970008038 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 562970008039 heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885 562970008040 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 562970008041 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 562970008042 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970008043 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 562970008044 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 562970008045 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 562970008046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 562970008047 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970008048 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 562970008049 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 562970008050 Walker A/P-loop; other site 562970008051 ATP binding site [chemical binding]; other site 562970008052 Q-loop/lid; other site 562970008053 ABC transporter signature motif; other site 562970008054 Walker B; other site 562970008055 D-loop; other site 562970008056 H-loop/switch region; other site 562970008057 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 562970008058 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 562970008059 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 562970008060 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 562970008061 AAA domain; Region: AAA_11; pfam13086 562970008062 Part of AAA domain; Region: AAA_19; pfam13245 562970008063 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 562970008064 AAA domain; Region: AAA_12; pfam13087 562970008065 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 562970008066 putative active site [active] 562970008067 Protein of unknown function (DUF3320); Region: DUF3320; pfam11784 562970008068 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 562970008069 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 562970008070 Walker A/P-loop; other site 562970008071 ATP binding site [chemical binding]; other site 562970008072 Q-loop/lid; other site 562970008073 ABC transporter signature motif; other site 562970008074 Walker B; other site 562970008075 D-loop; other site 562970008076 H-loop/switch region; other site 562970008077 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 562970008078 EamA-like transporter family; Region: EamA; pfam00892 562970008079 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 562970008080 transaminase; Reviewed; Region: PRK08068 562970008081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 562970008082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970008083 homodimer interface [polypeptide binding]; other site 562970008084 catalytic residue [active] 562970008085 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 562970008086 Amidase; Region: Amidase; pfam01425 562970008087 Transposase domain (DUF772); Region: DUF772; pfam05598 562970008088 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970008089 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970008090 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970008091 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 562970008092 Putative transposase; Region: Y2_Tnp; pfam04986 562970008093 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 562970008094 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 562970008095 pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188 562970008096 Int/Topo IB signature motif; other site 562970008097 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 562970008098 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 562970008099 active site 562970008100 DNA binding site [nucleotide binding] 562970008101 Int/Topo IB signature motif; other site 562970008102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970008103 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970008104 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970008105 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 562970008106 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970008107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 562970008108 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 562970008109 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 562970008110 DNA-binding interface [nucleotide binding]; DNA binding site 562970008111 Integrase core domain; Region: rve; pfam00665 562970008112 Integrase core domain; Region: rve; pfam00665 562970008113 Integrase core domain; Region: rve_3; pfam13683 562970008114 Transposase domain (DUF772); Region: DUF772; pfam05598 562970008115 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970008116 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970008117 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970008118 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 562970008119 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 562970008120 dimer interface [polypeptide binding]; other site 562970008121 FMN binding site [chemical binding]; other site 562970008122 NADPH bind site [chemical binding]; other site 562970008123 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 562970008124 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 562970008125 active site 562970008126 metal binding site [ion binding]; metal-binding site 562970008127 hypothetical protein; Provisional; Region: PRK08201 562970008128 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 562970008129 metal binding site [ion binding]; metal-binding site 562970008130 putative dimer interface [polypeptide binding]; other site 562970008131 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 562970008132 XdhC Rossmann domain; Region: XdhC_C; pfam13478 562970008133 YHS domain; Region: YHS; pfam04945 562970008134 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 562970008135 putative hydrophobic ligand binding site [chemical binding]; other site 562970008136 MoxR-like ATPases [General function prediction only]; Region: COG0714 562970008137 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 562970008139 Walker A motif; other site 562970008140 ATP binding site [chemical binding]; other site 562970008141 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 562970008142 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 562970008143 metal ion-dependent adhesion site (MIDAS); other site 562970008144 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 562970008145 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 562970008146 XdhC Rossmann domain; Region: XdhC_C; pfam13478 562970008147 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 562970008148 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970008149 non-specific DNA binding site [nucleotide binding]; other site 562970008150 salt bridge; other site 562970008151 sequence-specific DNA binding site [nucleotide binding]; other site 562970008152 Cupin domain; Region: Cupin_2; pfam07883 562970008153 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 562970008154 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 562970008155 Walker A/P-loop; other site 562970008156 ATP binding site [chemical binding]; other site 562970008157 Q-loop/lid; other site 562970008158 ABC transporter signature motif; other site 562970008159 Walker B; other site 562970008160 D-loop; other site 562970008161 H-loop/switch region; other site 562970008162 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 562970008163 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 562970008164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 562970008165 Walker A/P-loop; other site 562970008166 ATP binding site [chemical binding]; other site 562970008167 Q-loop/lid; other site 562970008168 ABC transporter signature motif; other site 562970008169 Walker B; other site 562970008170 D-loop; other site 562970008171 H-loop/switch region; other site 562970008172 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 562970008173 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 562970008174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008175 dimer interface [polypeptide binding]; other site 562970008176 conserved gate region; other site 562970008177 putative PBP binding loops; other site 562970008178 ABC-ATPase subunit interface; other site 562970008179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 562970008180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008181 dimer interface [polypeptide binding]; other site 562970008182 conserved gate region; other site 562970008183 putative PBP binding loops; other site 562970008184 ABC-ATPase subunit interface; other site 562970008185 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 562970008186 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 562970008187 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 562970008188 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970008189 active site 562970008190 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 562970008191 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 562970008192 acyl-activating enzyme (AAE) consensus motif; other site 562970008193 AMP binding site [chemical binding]; other site 562970008194 active site 562970008195 CoA binding site [chemical binding]; other site 562970008196 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970008197 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970008198 putative substrate translocation pore; other site 562970008199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970008200 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970008201 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 562970008202 Transposase domain (DUF772); Region: DUF772; pfam05598 562970008203 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970008204 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970008205 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970008206 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 562970008207 metal-binding site [ion binding] 562970008208 mercuric reductase; Region: MerA; TIGR02053 562970008209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970008210 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 562970008211 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970008212 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970008213 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 562970008214 dimerization interface [polypeptide binding]; other site 562970008215 putative DNA binding site [nucleotide binding]; other site 562970008216 putative Zn2+ binding site [ion binding]; other site 562970008217 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970008218 DNA binding residues [nucleotide binding] 562970008219 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970008220 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 562970008221 catalytic residues [active] 562970008222 catalytic nucleophile [active] 562970008223 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970008224 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970008225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970008226 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970008227 putative substrate translocation pore; other site 562970008228 Predicted transcriptional regulators [Transcription]; Region: COG1695 562970008229 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 562970008230 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 562970008231 active site 562970008232 intersubunit interface [polypeptide binding]; other site 562970008233 Zn2+ binding site [ion binding]; other site 562970008234 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 562970008235 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 562970008236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970008237 S-adenosylmethionine binding site [chemical binding]; other site 562970008238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970008239 S-adenosylmethionine binding site [chemical binding]; other site 562970008240 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 562970008241 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 562970008242 GatB domain; Region: GatB_Yqey; smart00845 562970008243 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 562970008244 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 562970008245 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 562970008246 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 562970008247 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 562970008248 Mg++ binding site [ion binding]; other site 562970008249 putative catalytic motif [active] 562970008250 substrate binding site [chemical binding]; other site 562970008251 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 562970008252 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 562970008253 nucleotide binding pocket [chemical binding]; other site 562970008254 K-X-D-G motif; other site 562970008255 catalytic site [active] 562970008256 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 562970008257 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 562970008258 Helix-hairpin-helix motif; Region: HHH; pfam00633 562970008259 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 562970008260 Dimer interface [polypeptide binding]; other site 562970008261 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 562970008262 Part of AAA domain; Region: AAA_19; pfam13245 562970008263 Family description; Region: UvrD_C_2; pfam13538 562970008264 Trp repressor protein; Region: Trp_repressor; cl17266 562970008265 enoyl-CoA hydratase; Provisional; Region: PRK08140 562970008266 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970008267 substrate binding site [chemical binding]; other site 562970008268 oxyanion hole (OAH) forming residues; other site 562970008269 trimer interface [polypeptide binding]; other site 562970008270 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 562970008271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970008272 sequence-specific DNA binding site [nucleotide binding]; other site 562970008273 salt bridge; other site 562970008274 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 562970008275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970008276 non-specific DNA binding site [nucleotide binding]; other site 562970008277 salt bridge; other site 562970008278 sequence-specific DNA binding site [nucleotide binding]; other site 562970008279 peptide chain release factor 2; Validated; Region: prfB; PRK00578 562970008280 This domain is found in peptide chain release factors; Region: PCRF; smart00937 562970008281 RF-1 domain; Region: RF-1; pfam00472 562970008282 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 562970008283 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 562970008284 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970008285 nucleotide binding region [chemical binding]; other site 562970008286 ATP-binding site [chemical binding]; other site 562970008287 SEC-C motif; Region: SEC-C; pfam02810 562970008288 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 562970008289 30S subunit binding site; other site 562970008290 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 562970008291 DNA-binding site [nucleotide binding]; DNA binding site 562970008292 RNA-binding motif; other site 562970008293 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 562970008294 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 562970008295 Walker A/P-loop; other site 562970008296 ATP binding site [chemical binding]; other site 562970008297 Q-loop/lid; other site 562970008298 ABC transporter signature motif; other site 562970008299 Walker B; other site 562970008300 D-loop; other site 562970008301 H-loop/switch region; other site 562970008302 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 562970008303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008304 dimer interface [polypeptide binding]; other site 562970008305 conserved gate region; other site 562970008306 putative PBP binding loops; other site 562970008307 ABC-ATPase subunit interface; other site 562970008308 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 562970008309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 562970008310 substrate binding pocket [chemical binding]; other site 562970008311 membrane-bound complex binding site; other site 562970008312 hinge residues; other site 562970008313 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 562970008314 putative active site [active] 562970008315 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 562970008316 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 562970008317 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 562970008318 Flagellar protein FliS; Region: FliS; cl00654 562970008319 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 562970008320 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 562970008321 FlaG protein; Region: FlaG; pfam03646 562970008322 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 562970008323 EamA-like transporter family; Region: EamA; pfam00892 562970008324 EamA-like transporter family; Region: EamA; pfam00892 562970008325 Transposase, Mutator family; Region: Transposase_mut; pfam00872 562970008326 MULE transposase domain; Region: MULE; pfam10551 562970008327 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 562970008328 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 562970008329 CAAX protease self-immunity; Region: Abi; pfam02517 562970008330 CAAX protease self-immunity; Region: Abi; pfam02517 562970008331 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 562970008332 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 562970008333 active site 562970008334 zinc binding site [ion binding]; other site 562970008335 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 562970008336 active site 562970008337 catalytic triad [active] 562970008338 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 562970008339 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 562970008340 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 562970008341 putative active site [active] 562970008342 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 562970008343 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 562970008344 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008345 Walker A/P-loop; other site 562970008346 ATP binding site [chemical binding]; other site 562970008347 Q-loop/lid; other site 562970008348 ABC transporter signature motif; other site 562970008349 Walker B; other site 562970008350 D-loop; other site 562970008351 H-loop/switch region; other site 562970008352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970008353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970008354 DNA binding residues [nucleotide binding] 562970008355 dimerization interface [polypeptide binding]; other site 562970008356 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 562970008357 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 562970008358 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 562970008359 CAAX protease self-immunity; Region: Abi; pfam02517 562970008360 CAAX protease self-immunity; Region: Abi; pfam02517 562970008361 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970008362 Peptidase family M48; Region: Peptidase_M48; cl12018 562970008363 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 562970008364 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 562970008365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970008366 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970008367 putative substrate translocation pore; other site 562970008368 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 562970008369 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 562970008370 active site 562970008371 Glyco_18 domain; Region: Glyco_18; smart00636 562970008372 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 562970008373 putative active site [active] 562970008374 catalytic site [active] 562970008375 DEAD-like helicases superfamily; Region: DEXDc; smart00487 562970008376 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 562970008377 ATP binding site [chemical binding]; other site 562970008378 putative Mg++ binding site [ion binding]; other site 562970008379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 562970008380 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 562970008381 nucleotide binding region [chemical binding]; other site 562970008382 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 562970008383 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 562970008384 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 562970008385 Methyltransferase domain; Region: Methyltransf_26; pfam13659 562970008386 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 562970008387 Protein of unknown function (DUF499); Region: DUF499; pfam04465 562970008388 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970008389 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598 562970008390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 562970008391 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 562970008392 metal binding site [ion binding]; metal-binding site 562970008393 active site 562970008394 I-site; other site 562970008395 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 562970008396 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 562970008397 Walker A/P-loop; other site 562970008398 ATP binding site [chemical binding]; other site 562970008399 Q-loop/lid; other site 562970008400 ABC transporter signature motif; other site 562970008401 Walker B; other site 562970008402 D-loop; other site 562970008403 H-loop/switch region; other site 562970008404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008405 dimer interface [polypeptide binding]; other site 562970008406 conserved gate region; other site 562970008407 putative PBP binding loops; other site 562970008408 ABC-ATPase subunit interface; other site 562970008409 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 562970008410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008411 dimer interface [polypeptide binding]; other site 562970008412 conserved gate region; other site 562970008413 putative PBP binding loops; other site 562970008414 ABC-ATPase subunit interface; other site 562970008415 PBP superfamily domain; Region: PBP_like_2; cl17296 562970008416 Phosphoglycerate kinase; Region: PGK; pfam00162 562970008417 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 562970008418 substrate binding site [chemical binding]; other site 562970008419 hinge regions; other site 562970008420 ADP binding site [chemical binding]; other site 562970008421 catalytic site [active] 562970008422 Transcriptional regulator [Transcription]; Region: LysR; COG0583 562970008423 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 562970008424 The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419 562970008425 putative dimerization interface [polypeptide binding]; other site 562970008426 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 562970008427 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 562970008428 intersubunit interface [polypeptide binding]; other site 562970008429 active site 562970008430 zinc binding site [ion binding]; other site 562970008431 Na+ binding site [ion binding]; other site 562970008432 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 562970008433 active site 562970008434 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 562970008435 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 562970008436 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 562970008437 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 562970008438 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 562970008439 putative active site [active] 562970008440 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 562970008441 Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212 562970008442 homodimer interface [polypeptide binding]; other site 562970008443 active site 562970008444 heterodimer interface [polypeptide binding]; other site 562970008445 catalytic residue [active] 562970008446 metal binding site [ion binding]; metal-binding site 562970008447 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 562970008448 multimerization interface [polypeptide binding]; other site 562970008449 CbbX; Provisional; Region: cbbX; CHL00181 562970008450 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970008451 Walker A motif; other site 562970008452 ATP binding site [chemical binding]; other site 562970008453 Walker B motif; other site 562970008454 arginine finger; other site 562970008455 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 562970008456 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 562970008457 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 562970008458 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 562970008459 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 562970008460 TPP-binding site [chemical binding]; other site 562970008461 dimer interface [polypeptide binding]; other site 562970008462 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 562970008463 PYR/PP interface [polypeptide binding]; other site 562970008464 dimer interface [polypeptide binding]; other site 562970008465 TPP binding site [chemical binding]; other site 562970008466 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 562970008467 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 562970008468 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 562970008469 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 562970008470 NADH dehydrogenase subunit B; Validated; Region: PRK06411 562970008471 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 562970008472 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 562970008473 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 562970008474 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 562970008475 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 562970008476 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 562970008477 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 562970008478 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 562970008479 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 562970008480 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 562970008481 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 562970008482 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 562970008483 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 562970008484 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 562970008485 PAS domain; Region: PAS_9; pfam13426 562970008486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970008487 putative active site [active] 562970008488 heme pocket [chemical binding]; other site 562970008489 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 562970008490 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970008491 Walker A motif; other site 562970008492 ATP binding site [chemical binding]; other site 562970008493 Walker B motif; other site 562970008494 arginine finger; other site 562970008495 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 562970008496 histidinol dehydrogenase; Region: hisD; TIGR00069 562970008497 NAD binding site [chemical binding]; other site 562970008498 dimerization interface [polypeptide binding]; other site 562970008499 product binding site; other site 562970008500 substrate binding site [chemical binding]; other site 562970008501 zinc binding site [ion binding]; other site 562970008502 catalytic residues [active] 562970008503 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 562970008504 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 562970008505 substrate binding pocket [chemical binding]; other site 562970008506 membrane-bound complex binding site; other site 562970008507 hinge residues; other site 562970008508 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 562970008509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008510 dimer interface [polypeptide binding]; other site 562970008511 conserved gate region; other site 562970008512 putative PBP binding loops; other site 562970008513 ABC-ATPase subunit interface; other site 562970008514 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 562970008515 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 562970008516 Walker A/P-loop; other site 562970008517 ATP binding site [chemical binding]; other site 562970008518 Q-loop/lid; other site 562970008519 ABC transporter signature motif; other site 562970008520 Walker B; other site 562970008521 D-loop; other site 562970008522 H-loop/switch region; other site 562970008523 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970008524 DNA-binding site [nucleotide binding]; DNA binding site 562970008525 transcriptional regulator NanR; Provisional; Region: PRK03837 562970008526 FCD domain; Region: FCD; pfam07729 562970008527 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 562970008528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970008529 NAD(P) binding site [chemical binding]; other site 562970008530 active site 562970008531 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 562970008532 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 562970008533 TAP-like protein; Region: Abhydrolase_4; pfam08386 562970008534 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 562970008535 inter-subunit interface; other site 562970008536 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 562970008537 iron-sulfur cluster [ion binding]; other site 562970008538 [2Fe-2S] cluster binding site [ion binding]; other site 562970008539 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 562970008540 beta subunit interface [polypeptide binding]; other site 562970008541 alpha subunit interface [polypeptide binding]; other site 562970008542 active site 562970008543 substrate binding site [chemical binding]; other site 562970008544 Fe binding site [ion binding]; other site 562970008545 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 562970008546 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 562970008547 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 562970008548 active site 562970008549 Fe binding site [ion binding]; other site 562970008550 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 562970008551 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 562970008552 active site 562970008553 catalytic tetrad [active] 562970008554 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 562970008555 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 562970008556 HicB family; Region: HicB; pfam05534 562970008557 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 562970008558 active site clefts [active] 562970008559 zinc binding site [ion binding]; other site 562970008560 dimer interface [polypeptide binding]; other site 562970008561 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970008562 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 562970008563 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970008564 Zn2+ binding site [ion binding]; other site 562970008565 Mg2+ binding site [ion binding]; other site 562970008566 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970008567 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 562970008568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970008569 dimerization interface [polypeptide binding]; other site 562970008570 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970008571 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970008572 dimer interface [polypeptide binding]; other site 562970008573 putative CheW interface [polypeptide binding]; other site 562970008574 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 562970008575 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 562970008576 PIN domain; Region: PIN_3; cl17397 562970008577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008578 Walker A/P-loop; other site 562970008579 ATP binding site [chemical binding]; other site 562970008580 AAA domain; Region: AAA_21; pfam13304 562970008581 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 562970008582 YcfA-like protein; Region: YcfA; cl00752 562970008583 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 562970008584 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 562970008585 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 562970008586 active site 562970008587 catalytic tetrad [active] 562970008588 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 562970008589 YcfA-like protein; Region: YcfA; pfam07927 562970008590 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 562970008591 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 562970008592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008593 AAA domain; Region: AAA_23; pfam13476 562970008594 AAA domain; Region: AAA_21; pfam13304 562970008595 Walker A/P-loop; other site 562970008596 ATP binding site [chemical binding]; other site 562970008597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008598 Walker B; other site 562970008599 D-loop; other site 562970008600 H-loop/switch region; other site 562970008601 HNH endonuclease; Region: HNH_2; pfam13391 562970008602 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 562970008603 PIN domain; Region: PIN_3; cl17397 562970008604 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 562970008605 YcfA-like protein; Region: YcfA; cl00752 562970008606 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 562970008607 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 562970008608 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 562970008609 HsdM N-terminal domain; Region: HsdM_N; pfam12161 562970008610 Methyltransferase domain; Region: Methyltransf_26; pfam13659 562970008611 HsdM N-terminal domain; Region: HsdM_N; pfam12161 562970008612 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 562970008613 Methyltransferase domain; Region: Methyltransf_26; pfam13659 562970008614 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 562970008615 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 562970008616 Mrr N-terminal domain; Region: Mrr_N; pfam14338 562970008617 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 562970008618 active site 562970008619 NTP binding site [chemical binding]; other site 562970008620 metal binding triad [ion binding]; metal-binding site 562970008621 antibiotic binding site [chemical binding]; other site 562970008622 Uncharacterized conserved protein [Function unknown]; Region: COG2361 562970008623 Transposase [DNA replication, recombination, and repair]; Region: COG5421 562970008624 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 562970008625 HicB family; Region: HicB; pfam05534 562970008626 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 562970008627 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 562970008628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008629 Walker A/P-loop; other site 562970008630 ATP binding site [chemical binding]; other site 562970008631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008632 Walker B; other site 562970008633 D-loop; other site 562970008634 H-loop/switch region; other site 562970008635 RES domain; Region: RES; pfam08808 562970008636 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 562970008637 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 562970008638 Global regulator protein family; Region: CsrA; cl00670 562970008639 FliW protein; Region: FliW; pfam02623 562970008640 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 562970008641 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 562970008642 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 562970008643 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 562970008644 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 562970008645 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 562970008646 amphi-Trp domain; Region: amphi-Trp; TIGR04354 562970008647 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 562970008648 FlgN protein; Region: FlgN; pfam05130 562970008649 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 562970008650 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970008651 putative active site [active] 562970008652 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 562970008653 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 562970008654 Zn2+ binding site [ion binding]; other site 562970008655 Mg2+ binding site [ion binding]; other site 562970008656 flagellar operon protein TIGR03826; Region: YvyF 562970008657 Spore germination protein; Region: Spore_permease; cl17796 562970008658 Amino acid permease; Region: AA_permease_2; pfam13520 562970008659 comF family protein; Region: comF; TIGR00201 562970008660 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970008661 active site 562970008662 EDD domain protein, DegV family; Region: DegV; TIGR00762 562970008663 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 562970008664 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 562970008665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970008666 Walker A motif; other site 562970008667 ATP binding site [chemical binding]; other site 562970008668 Family description; Region: UvrD_C_2; pfam13538 562970008669 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 562970008670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 562970008671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970008672 active site 562970008673 phosphorylation site [posttranslational modification] 562970008674 intermolecular recognition site; other site 562970008675 dimerization interface [polypeptide binding]; other site 562970008676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 562970008677 DNA binding residues [nucleotide binding] 562970008678 dimerization interface [polypeptide binding]; other site 562970008679 S-adenosylmethionine synthetase; Validated; Region: PRK05250 562970008680 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 562970008681 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 562970008682 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 562970008683 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 562970008684 dinuclear metal binding motif [ion binding]; other site 562970008685 Predicted membrane protein [Function unknown]; Region: COG2323 562970008686 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 562970008687 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 562970008688 Transcriptional regulator [Transcription]; Region: LytR; COG1316 562970008689 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 562970008690 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 562970008691 putative active site [active] 562970008692 putative metal binding site [ion binding]; other site 562970008693 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970008694 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 562970008695 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 562970008696 CHASE3 domain; Region: CHASE3; pfam05227 562970008697 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 562970008698 dimerization interface [polypeptide binding]; other site 562970008699 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970008700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 562970008701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970008702 dimer interface [polypeptide binding]; other site 562970008703 putative CheW interface [polypeptide binding]; other site 562970008704 S-layer homology domain; Region: SLH; pfam00395 562970008705 S-layer homology domain; Region: SLH; pfam00395 562970008706 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 562970008707 Patatin-like phospholipase; Region: Patatin; pfam01734 562970008708 nucleophile elbow; other site 562970008709 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 562970008710 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 562970008711 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 562970008712 FMN binding site [chemical binding]; other site 562970008713 substrate binding site [chemical binding]; other site 562970008714 putative catalytic residue [active] 562970008715 LabA_like proteins; Region: LabA_like; cd06167 562970008716 putative metal binding site [ion binding]; other site 562970008717 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 562970008718 AAA domain; Region: AAA_18; pfam13238 562970008719 AAA domain; Region: AAA_17; pfam13207 562970008720 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 562970008721 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 562970008722 active site 562970008723 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 562970008724 dimer interface [polypeptide binding]; other site 562970008725 substrate binding site [chemical binding]; other site 562970008726 catalytic residues [active] 562970008727 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 562970008728 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 562970008729 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 562970008730 Transcriptional regulator [Transcription]; Region: LytR; COG1316 562970008731 Transposase domain (DUF772); Region: DUF772; pfam05598 562970008732 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970008733 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970008734 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970008735 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 562970008736 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970008737 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 562970008738 putative active site pocket [active] 562970008739 cleavage site 562970008740 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 562970008741 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 562970008742 intersubunit interface [polypeptide binding]; other site 562970008743 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 562970008744 active site 562970008745 Zn2+ binding site [ion binding]; other site 562970008746 Transposase; Region: DEDD_Tnp_IS110; pfam01548 562970008747 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 562970008748 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 562970008749 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 562970008750 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 562970008751 EamA-like transporter family; Region: EamA; pfam00892 562970008752 EamA-like transporter family; Region: EamA; pfam00892 562970008753 AAA domain; Region: AAA_17; pfam13207 562970008754 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 562970008755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970008756 DNA-binding site [nucleotide binding]; DNA binding site 562970008757 FCD domain; Region: FCD; pfam07729 562970008758 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 562970008759 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970008760 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483 562970008761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 562970008762 Winged helix-turn helix; Region: HTH_29; pfam13551 562970008763 DDE superfamily endonuclease; Region: DDE_3; pfam13358 562970008764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 562970008765 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970008766 enoyl-CoA hydratase; Provisional; Region: PRK06144 562970008767 substrate binding site [chemical binding]; other site 562970008768 oxyanion hole (OAH) forming residues; other site 562970008769 trimer interface [polypeptide binding]; other site 562970008770 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 562970008771 CoA-transferase family III; Region: CoA_transf_3; pfam02515 562970008772 metabolite-proton symporter; Region: 2A0106; TIGR00883 562970008773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970008774 putative substrate translocation pore; other site 562970008775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008776 Walker A/P-loop; other site 562970008777 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 562970008778 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 562970008779 Predicted membrane protein [Function unknown]; Region: COG4684 562970008780 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 562970008781 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 562970008782 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 562970008783 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 562970008784 Walker A/P-loop; other site 562970008785 ATP binding site [chemical binding]; other site 562970008786 Q-loop/lid; other site 562970008787 ABC transporter signature motif; other site 562970008788 Walker B; other site 562970008789 D-loop; other site 562970008790 H-loop/switch region; other site 562970008791 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634 562970008792 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 562970008793 Walker A/P-loop; other site 562970008794 ATP binding site [chemical binding]; other site 562970008795 Q-loop/lid; other site 562970008796 ABC transporter signature motif; other site 562970008797 Walker B; other site 562970008798 D-loop; other site 562970008799 H-loop/switch region; other site 562970008800 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 562970008801 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 562970008802 metal binding site [ion binding]; metal-binding site 562970008803 dimer interface [polypeptide binding]; other site 562970008804 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 562970008805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970008806 NAD(P) binding site [chemical binding]; other site 562970008807 active site 562970008808 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 562970008809 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 562970008810 NAD(P) binding site [chemical binding]; other site 562970008811 catalytic residues [active] 562970008812 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 562970008813 tartrate dehydrogenase; Region: TTC; TIGR02089 562970008814 PAS domain S-box; Region: sensory_box; TIGR00229 562970008815 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 562970008816 putative active site [active] 562970008817 heme pocket [chemical binding]; other site 562970008818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 562970008819 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 562970008820 Walker A motif; other site 562970008821 ATP binding site [chemical binding]; other site 562970008822 Walker B motif; other site 562970008823 arginine finger; other site 562970008824 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 562970008825 trimer interface [polypeptide binding]; other site 562970008826 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 562970008827 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 562970008828 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 562970008829 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 562970008830 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 562970008831 putative ligand binding site [chemical binding]; other site 562970008832 putative NAD binding site [chemical binding]; other site 562970008833 catalytic site [active] 562970008834 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 562970008835 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 562970008836 active site 562970008837 non-prolyl cis peptide bond; other site 562970008838 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 562970008839 homotrimer interaction site [polypeptide binding]; other site 562970008840 putative active site [active] 562970008841 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 562970008842 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 562970008843 dimerization interface [polypeptide binding]; other site 562970008844 ligand binding site [chemical binding]; other site 562970008845 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 562970008846 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 562970008847 TM-ABC transporter signature motif; other site 562970008848 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 562970008849 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 562970008850 Walker A/P-loop; other site 562970008851 ATP binding site [chemical binding]; other site 562970008852 Q-loop/lid; other site 562970008853 ABC transporter signature motif; other site 562970008854 Walker B; other site 562970008855 D-loop; other site 562970008856 H-loop/switch region; other site 562970008857 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 562970008858 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 562970008859 Walker A/P-loop; other site 562970008860 ATP binding site [chemical binding]; other site 562970008861 Q-loop/lid; other site 562970008862 ABC transporter signature motif; other site 562970008863 Walker B; other site 562970008864 D-loop; other site 562970008865 H-loop/switch region; other site 562970008866 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 562970008867 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 562970008868 TM-ABC transporter signature motif; other site 562970008869 Transcriptional regulator [Transcription]; Region: LysR; COG0583 562970008870 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 562970008871 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 562970008872 dimerization interface [polypeptide binding]; other site 562970008873 Domain of unknown function (DUF4338); Region: DUF4338; pfam14236 562970008874 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 562970008875 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 562970008876 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 562970008877 L-serine binding site [chemical binding]; other site 562970008878 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 562970008879 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 562970008880 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 562970008881 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 562970008882 inhibitor site; inhibition site 562970008883 active site 562970008884 dimer interface [polypeptide binding]; other site 562970008885 catalytic residue [active] 562970008886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970008887 NAD(P) binding site [chemical binding]; other site 562970008888 active site 562970008889 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 562970008890 putative sialic acid transporter; Region: 2A0112; TIGR00891 562970008891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970008892 putative substrate translocation pore; other site 562970008893 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 562970008894 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 562970008895 metal binding site [ion binding]; metal-binding site 562970008896 dimer interface [polypeptide binding]; other site 562970008897 Predicted transcriptional regulator [Transcription]; Region: COG2345 562970008898 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 562970008899 aminotransferase; Validated; Region: PRK07678 562970008900 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 562970008901 inhibitor-cofactor binding pocket; inhibition site 562970008902 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970008903 catalytic residue [active] 562970008904 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 562970008905 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 562970008906 hexamer interface [polypeptide binding]; other site 562970008907 ligand binding site [chemical binding]; other site 562970008908 putative active site [active] 562970008909 NAD(P) binding site [chemical binding]; other site 562970008910 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 562970008911 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 562970008912 tetrameric interface [polypeptide binding]; other site 562970008913 NAD binding site [chemical binding]; other site 562970008914 catalytic residues [active] 562970008915 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 562970008916 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 562970008917 putative active site [active] 562970008918 putative mechanosensitive channel protein; Provisional; Region: PRK10929 562970008919 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 562970008920 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 562970008921 active site 562970008922 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 562970008923 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 562970008924 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970008925 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970008926 active site 562970008927 phosphonate C-P lyase system protein PhnL; Region: CP_lyasePhnL; TIGR02324 562970008928 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970008929 Walker A/P-loop; other site 562970008930 ATP binding site [chemical binding]; other site 562970008931 Q-loop/lid; other site 562970008932 ABC transporter signature motif; other site 562970008933 Walker B; other site 562970008934 D-loop; other site 562970008935 H-loop/switch region; other site 562970008936 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 562970008937 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 562970008938 Walker A/P-loop; other site 562970008939 ATP binding site [chemical binding]; other site 562970008940 Q-loop/lid; other site 562970008941 ABC transporter signature motif; other site 562970008942 Walker B; other site 562970008943 D-loop; other site 562970008944 H-loop/switch region; other site 562970008945 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 562970008946 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 562970008947 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 562970008948 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 562970008949 phosphonate C-P lyase system protein PhnG; Region: PhnG_redo; TIGR03293 562970008950 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 562970008951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 562970008952 DNA-binding site [nucleotide binding]; DNA binding site 562970008953 UTRA domain; Region: UTRA; pfam07702 562970008954 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 562970008955 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970008956 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 562970008957 active site 562970008958 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 562970008959 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 562970008960 trimer interface [polypeptide binding]; other site 562970008961 active site 562970008962 substrate binding site [chemical binding]; other site 562970008963 CoA binding site [chemical binding]; other site 562970008964 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 562970008965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008966 dimer interface [polypeptide binding]; other site 562970008967 conserved gate region; other site 562970008968 putative PBP binding loops; other site 562970008969 ABC-ATPase subunit interface; other site 562970008970 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 562970008971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970008972 dimer interface [polypeptide binding]; other site 562970008973 conserved gate region; other site 562970008974 ABC-ATPase subunit interface; other site 562970008975 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 562970008976 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 562970008977 Walker A/P-loop; other site 562970008978 ATP binding site [chemical binding]; other site 562970008979 Q-loop/lid; other site 562970008980 ABC transporter signature motif; other site 562970008981 Walker B; other site 562970008982 D-loop; other site 562970008983 H-loop/switch region; other site 562970008984 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 562970008985 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 562970008986 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 562970008987 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 562970008988 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 562970008989 NAD binding site [chemical binding]; other site 562970008990 homodimer interface [polypeptide binding]; other site 562970008991 homotetramer interface [polypeptide binding]; other site 562970008992 active site 562970008993 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 562970008994 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 562970008995 dimer interface [polypeptide binding]; other site 562970008996 acyl-activating enzyme (AAE) consensus motif; other site 562970008997 putative active site [active] 562970008998 AMP binding site [chemical binding]; other site 562970008999 putative CoA binding site [chemical binding]; other site 562970009000 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 562970009001 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 562970009002 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 562970009003 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 562970009004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970009005 putative substrate translocation pore; other site 562970009006 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 562970009007 lipoyl-biotinyl attachment site [posttranslational modification]; other site 562970009008 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 562970009009 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 562970009010 carboxyltransferase (CT) interaction site; other site 562970009011 biotinylation site [posttranslational modification]; other site 562970009012 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970009013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 562970009014 MarR family; Region: MarR_2; pfam12802 562970009015 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 562970009016 Predicted amidohydrolase [General function prediction only]; Region: COG0388 562970009017 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 562970009018 putative active site [active] 562970009019 catalytic triad [active] 562970009020 putative dimer interface [polypeptide binding]; other site 562970009021 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 562970009022 arsenical pump membrane protein; Provisional; Region: PRK15445 562970009023 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 562970009024 transmembrane helices; other site 562970009025 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 562970009026 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 562970009027 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 562970009028 Walker A motif; other site 562970009029 ATP binding site [chemical binding]; other site 562970009030 Walker B motif; other site 562970009031 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 562970009032 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 562970009033 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 562970009034 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 562970009035 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 562970009036 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 562970009037 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 562970009038 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 562970009039 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 562970009040 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 562970009041 Uncharacterized conserved protein [Function unknown]; Region: COG2135 562970009042 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 562970009043 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 562970009044 oligomer interface [polypeptide binding]; other site 562970009045 active site 562970009046 metal binding site [ion binding]; metal-binding site 562970009047 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 562970009048 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 562970009049 oligomer interface [polypeptide binding]; other site 562970009050 active site 562970009051 metal binding site [ion binding]; metal-binding site 562970009052 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 562970009053 metal binding site [ion binding]; metal-binding site 562970009054 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 562970009055 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 562970009056 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 562970009057 Ligand binding site; other site 562970009058 Putative Catalytic site; other site 562970009059 DXD motif; other site 562970009060 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 562970009061 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 562970009062 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 562970009063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970009064 Walker A/P-loop; other site 562970009065 ATP binding site [chemical binding]; other site 562970009066 Q-loop/lid; other site 562970009067 ABC transporter signature motif; other site 562970009068 Walker B; other site 562970009069 D-loop; other site 562970009070 H-loop/switch region; other site 562970009071 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 562970009072 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 562970009073 S-layer homology domain; Region: SLH; pfam00395 562970009074 S-layer homology domain; Region: SLH; pfam00395 562970009075 S-layer homology domain; Region: SLH; pfam00395 562970009076 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 562970009077 active site 562970009078 NTP binding site [chemical binding]; other site 562970009079 metal binding triad [ion binding]; metal-binding site 562970009080 antibiotic binding site [chemical binding]; other site 562970009081 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780 562970009082 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 562970009083 S-layer homology domain; Region: SLH; pfam00395 562970009084 S-layer homology domain; Region: SLH; pfam00395 562970009085 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 562970009086 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 562970009087 NAD(P) binding site [chemical binding]; other site 562970009088 GAF domain; Region: GAF; pfam01590 562970009089 GAF domain; Region: GAF_2; pfam13185 562970009090 GAF domain; Region: GAF_3; pfam13492 562970009091 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 562970009092 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 562970009093 metal binding site [ion binding]; metal-binding site 562970009094 active site 562970009095 I-site; other site 562970009096 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 562970009097 short chain dehydrogenase; Provisional; Region: PRK07102 562970009098 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 562970009099 NAD(P) binding site [chemical binding]; other site 562970009100 active site 562970009101 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 562970009102 FAD binding domain; Region: FAD_binding_4; pfam01565 562970009103 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 562970009104 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 562970009105 O-Antigen ligase; Region: Wzy_C; pfam04932 562970009106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 562970009107 TPR motif; other site 562970009108 binding surface 562970009109 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 562970009110 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 562970009111 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970009112 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 562970009113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970009114 putative substrate translocation pore; other site 562970009115 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 562970009116 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970009117 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 562970009118 E3 interaction surface; other site 562970009119 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 562970009120 lipoyl attachment site [posttranslational modification]; other site 562970009121 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970009122 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970009123 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 562970009124 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 562970009125 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 562970009126 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 562970009127 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970009128 Transposase domain (DUF772); Region: DUF772; pfam05598 562970009129 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970009130 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970009131 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970009132 Transposase domain (DUF772); Region: DUF772; pfam05598 562970009133 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 562970009134 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 562970009135 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 562970009136 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 562970009137 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970009138 DNA binding residues [nucleotide binding] 562970009139 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970009140 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970009141 catalytic residues [active] 562970009142 catalytic nucleophile [active] 562970009143 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 562970009144 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970009145 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 562970009146 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970009147 DNA binding residues [nucleotide binding] 562970009148 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970009149 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970009150 catalytic residues [active] 562970009151 catalytic nucleophile [active] 562970009152 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 562970009153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 562970009154 sequence-specific DNA binding site [nucleotide binding]; other site 562970009155 salt bridge; other site 562970009156 Domain of unknown function (DUF955); Region: DUF955; cl01076 562970009157 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 562970009158 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 562970009159 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970009160 putative active site [active] 562970009161 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 562970009162 prevent-host-death family protein; Region: phd_fam; TIGR01552 562970009163 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 562970009164 oligomeric interface; other site 562970009165 putative active site [active] 562970009166 homodimer interface [polypeptide binding]; other site 562970009167 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 562970009168 PemK-like protein; Region: PemK; cl00995 562970009169 Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336 562970009170 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 562970009171 putative active site [active] 562970009172 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 562970009173 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 562970009174 Protein export membrane protein; Region: SecD_SecF; cl14618 562970009175 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 562970009176 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 562970009177 HlyD family secretion protein; Region: HlyD_3; pfam13437 562970009178 Uncharacterized conserved protein [Function unknown]; Region: COG1739 562970009179 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 562970009180 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 562970009181 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 562970009182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 562970009183 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 562970009184 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 562970009185 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 562970009186 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 562970009187 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 562970009188 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 562970009189 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 562970009190 Stage III sporulation protein D; Region: SpoIIID; pfam12116 562970009191 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 562970009192 Peptidase family M23; Region: Peptidase_M23; pfam01551 562970009193 Stage II sporulation protein; Region: SpoIID; pfam08486 562970009194 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 562970009195 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 562970009196 dimer interface [polypeptide binding]; other site 562970009197 putative CheW interface [polypeptide binding]; other site 562970009198 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 562970009199 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 562970009200 hinge; other site 562970009201 active site 562970009202 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 562970009203 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 562970009204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 562970009205 Major Facilitator Superfamily; Region: MFS_1; pfam07690 562970009206 putative substrate translocation pore; other site 562970009207 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 562970009208 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 562970009209 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 562970009210 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 562970009211 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 562970009212 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 562970009213 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 562970009214 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 562970009215 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 562970009216 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 562970009217 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 562970009218 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 562970009219 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 562970009220 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 562970009221 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 562970009222 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 562970009223 NADH dehydrogenase subunit B; Validated; Region: PRK06411 562970009224 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 562970009225 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 562970009226 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 562970009227 gamma subunit interface [polypeptide binding]; other site 562970009228 epsilon subunit interface [polypeptide binding]; other site 562970009229 LBP interface [polypeptide binding]; other site 562970009230 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 562970009231 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 562970009232 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 562970009233 alpha subunit interaction interface [polypeptide binding]; other site 562970009234 Walker A motif; other site 562970009235 ATP binding site [chemical binding]; other site 562970009236 Walker B motif; other site 562970009237 inhibitor binding site; inhibition site 562970009238 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 562970009239 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 562970009240 core domain interface [polypeptide binding]; other site 562970009241 delta subunit interface [polypeptide binding]; other site 562970009242 epsilon subunit interface [polypeptide binding]; other site 562970009243 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 562970009244 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 562970009245 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 562970009246 beta subunit interaction interface [polypeptide binding]; other site 562970009247 Walker A motif; other site 562970009248 ATP binding site [chemical binding]; other site 562970009249 Walker B motif; other site 562970009250 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 562970009251 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 562970009252 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 562970009253 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 562970009254 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 562970009255 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 562970009256 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 562970009257 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 562970009258 putative acyltransferase; Provisional; Region: PRK05790 562970009259 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 562970009260 dimer interface [polypeptide binding]; other site 562970009261 active site 562970009262 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 562970009263 active site 562970009264 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 562970009265 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 562970009266 dimer interface [polypeptide binding]; other site 562970009267 active site 562970009268 glycine-pyridoxal phosphate binding site [chemical binding]; other site 562970009269 folate binding site [chemical binding]; other site 562970009270 hypothetical protein; Provisional; Region: PRK13690 562970009271 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 562970009272 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 562970009273 CPxP motif; other site 562970009274 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 562970009275 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 562970009276 Low molecular weight phosphatase family; Region: LMWPc; cd00115 562970009277 active site 562970009278 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 562970009279 ADP-ribose binding site [chemical binding]; other site 562970009280 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 562970009281 Domain of unknown function DUF; Region: DUF204; pfam02659 562970009282 Domain of unknown function DUF; Region: DUF204; pfam02659 562970009283 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 562970009284 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 562970009285 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 562970009286 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 562970009287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970009288 S-adenosylmethionine binding site [chemical binding]; other site 562970009289 peptide chain release factor 1; Validated; Region: prfA; PRK00591 562970009290 This domain is found in peptide chain release factors; Region: PCRF; smart00937 562970009291 RF-1 domain; Region: RF-1; pfam00472 562970009292 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 562970009293 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 562970009294 Predicted membrane protein [Function unknown]; Region: COG3462 562970009295 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 562970009296 transcription termination factor Rho; Provisional; Region: rho; PRK09376 562970009297 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 562970009298 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 562970009299 RNA binding site [nucleotide binding]; other site 562970009300 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 562970009301 multimer interface [polypeptide binding]; other site 562970009302 Walker A motif; other site 562970009303 ATP binding site [chemical binding]; other site 562970009304 Walker B motif; other site 562970009305 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 562970009306 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 562970009307 putative active site [active] 562970009308 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 562970009309 Zn binding site [ion binding]; other site 562970009310 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 562970009311 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 562970009312 metal binding site [ion binding]; metal-binding site 562970009313 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 562970009314 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 562970009315 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 562970009316 active site 562970009317 trimer interface [polypeptide binding]; other site 562970009318 substrate binding site [chemical binding]; other site 562970009319 CoA binding site [chemical binding]; other site 562970009320 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 562970009321 active site 562970009322 intersubunit interactions; other site 562970009323 catalytic residue [active] 562970009324 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 562970009325 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 562970009326 intersubunit interface [polypeptide binding]; other site 562970009327 active site 562970009328 zinc binding site [ion binding]; other site 562970009329 Na+ binding site [ion binding]; other site 562970009330 Response regulator receiver domain; Region: Response_reg; pfam00072 562970009331 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 562970009332 active site 562970009333 phosphorylation site [posttranslational modification] 562970009334 intermolecular recognition site; other site 562970009335 dimerization interface [polypeptide binding]; other site 562970009336 CTP synthetase; Validated; Region: pyrG; PRK05380 562970009337 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 562970009338 Catalytic site [active] 562970009339 active site 562970009340 UTP binding site [chemical binding]; other site 562970009341 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 562970009342 active site 562970009343 putative oxyanion hole; other site 562970009344 catalytic triad [active] 562970009345 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 562970009346 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 562970009347 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 562970009348 Walker A; other site 562970009349 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970009350 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 562970009351 FAD binding site [chemical binding]; other site 562970009352 homotetramer interface [polypeptide binding]; other site 562970009353 substrate binding pocket [chemical binding]; other site 562970009354 catalytic base [active] 562970009355 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 562970009356 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 562970009357 active site 562970009358 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 562970009359 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 562970009360 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 562970009361 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 562970009362 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 562970009363 dimer interface [polypeptide binding]; other site 562970009364 active site 562970009365 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 562970009366 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 562970009367 4Fe-4S binding domain; Region: Fer4; cl02805 562970009368 Cysteine-rich domain; Region: CCG; pfam02754 562970009369 Cysteine-rich domain; Region: CCG; pfam02754 562970009370 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 562970009371 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 562970009372 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 562970009373 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 562970009374 active site 562970009375 HIGH motif; other site 562970009376 KMSK motif region; other site 562970009377 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 562970009378 tRNA binding surface [nucleotide binding]; other site 562970009379 anticodon binding site; other site 562970009380 agmatinase; Region: agmatinase; TIGR01230 562970009381 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 562970009382 putative active site [active] 562970009383 Mn binding site [ion binding]; other site 562970009384 spermidine synthase; Provisional; Region: PRK00811 562970009385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970009386 S-adenosylmethionine binding site [chemical binding]; other site 562970009387 Transglycosylase; Region: Transgly; pfam00912 562970009388 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 562970009389 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 562970009390 aspartate aminotransferase; Provisional; Region: PRK05764 562970009391 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 562970009392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 562970009393 homodimer interface [polypeptide binding]; other site 562970009394 catalytic residue [active] 562970009395 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 562970009396 active site 562970009397 catalytic triad [active] 562970009398 oxyanion hole [active] 562970009399 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 562970009400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 562970009401 Walker A/P-loop; other site 562970009402 ATP binding site [chemical binding]; other site 562970009403 Q-loop/lid; other site 562970009404 ABC transporter signature motif; other site 562970009405 Walker B; other site 562970009406 D-loop; other site 562970009407 H-loop/switch region; other site 562970009408 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 562970009409 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970009410 dimer interface [polypeptide binding]; other site 562970009411 conserved gate region; other site 562970009412 putative PBP binding loops; other site 562970009413 ABC-ATPase subunit interface; other site 562970009414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 562970009415 dimer interface [polypeptide binding]; other site 562970009416 conserved gate region; other site 562970009417 putative PBP binding loops; other site 562970009418 ABC-ATPase subunit interface; other site 562970009419 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 562970009420 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 562970009421 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 562970009422 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 562970009423 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 562970009424 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 562970009425 protein binding site [polypeptide binding]; other site 562970009426 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 562970009427 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 562970009428 DNA binding residues [nucleotide binding] 562970009429 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 562970009430 catalytic residues [active] 562970009431 catalytic nucleophile [active] 562970009432 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 562970009433 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 562970009434 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 562970009435 GDP-binding site [chemical binding]; other site 562970009436 ACT binding site; other site 562970009437 IMP binding site; other site 562970009438 Cell division protein FtsA; Region: FtsA; smart00842 562970009439 cell division protein FtsA; Region: ftsA; TIGR01174 562970009440 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 562970009441 nucleotide binding site [chemical binding]; other site 562970009442 replicative DNA helicase; Region: DnaB; TIGR00665 562970009443 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 562970009444 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 562970009445 Walker A motif; other site 562970009446 ATP binding site [chemical binding]; other site 562970009447 Walker B motif; other site 562970009448 DNA binding loops [nucleotide binding] 562970009449 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 562970009450 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 562970009451 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 562970009452 MazG-like family; Region: MazG-like; pfam12643 562970009453 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 562970009454 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 562970009455 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 562970009456 dimer interface [polypeptide binding]; other site 562970009457 ssDNA binding site [nucleotide binding]; other site 562970009458 tetramer (dimer of dimers) interface [polypeptide binding]; other site 562970009459 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 562970009460 GTP-binding protein YchF; Reviewed; Region: PRK09601 562970009461 YchF GTPase; Region: YchF; cd01900 562970009462 G1 box; other site 562970009463 GTP/Mg2+ binding site [chemical binding]; other site 562970009464 Switch I region; other site 562970009465 G2 box; other site 562970009466 Switch II region; other site 562970009467 G3 box; other site 562970009468 G4 box; other site 562970009469 G5 box; other site 562970009470 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 562970009471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 562970009472 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 562970009473 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 562970009474 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 562970009475 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 562970009476 Protein of unknown function (DUF554); Region: DUF554; pfam04474 562970009477 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 562970009478 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 562970009479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 562970009480 catalytic residue [active] 562970009481 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 562970009482 ParB-like nuclease domain; Region: ParB; smart00470 562970009483 KorB domain; Region: KorB; pfam08535 562970009484 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 562970009485 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 562970009486 P-loop; other site 562970009487 Magnesium ion binding site [ion binding]; other site 562970009488 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 562970009489 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 562970009490 ParB-like nuclease domain; Region: ParB; smart00470 562970009491 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 562970009492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 562970009493 S-adenosylmethionine binding site [chemical binding]; other site 562970009494 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 562970009495 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 562970009496 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 562970009497 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 562970009498 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 562970009499 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 562970009500 GTP/Mg2+ binding site [chemical binding]; other site 562970009501 trmE is a tRNA modification GTPase; Region: trmE; cd04164 562970009502 G1 box; other site 562970009503 G1 box; other site 562970009504 GTP/Mg2+ binding site [chemical binding]; other site 562970009505 Switch I region; other site 562970009506 Switch I region; other site 562970009507 G2 box; other site 562970009508 G2 box; other site 562970009509 Switch II region; other site 562970009510 G3 box; other site 562970009511 G3 box; other site 562970009512 Switch II region; other site 562970009513 G4 box; other site 562970009514 G5 box; other site 562970009515 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 562970009516 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 562970009517 Haemolytic domain; Region: Haemolytic; pfam01809 562970009518 ribonuclease P; Reviewed; Region: rnpA; PRK00499 562970009519 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399